Molecule

N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide

AlkaPlorer ID: AK268173

Synonym: None

IUPAC Name: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Structure

SMILES: O=S(=O)(C1=CC=CC=C1)N(CC(F)(F)F)C1=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C1

InChI: InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2

InChIKey: SGIWFELWJPNFDH-UHFFFAOYSA-N

Reference

Polycyclic Polyprenylated Derivatives from <i>Hypericum uralum</i>: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A

PubChem CID: 447912

CAS: 293754-55-9

SuperNatural Ⅲ: SN0344758

NPASS: NPC462908

COCONUT: CNP0373072

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Aspergillus puniceus	Aspergillus	Aspergillaceae	Eurotiales	Eurotiomycetes	Ascomycota	Fungi	Eukaryota

Properties Information

Molecule Weight: 481.336

TPSA？: 57.61

MolLogP？: 4.756400000000003

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 2

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Canis lupus familiaris	Canis familiaris	AUC	7301.0	ng.hr.mL-1	10.1016/j.bmcl.2005.12.015
Canis lupus familiaris	Canis familiaris	T1/2	5.8	hr	10.1016/j.bmcl.2005.12.015
Cricetinae	Hamster	Activity	40.0	%	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	Activity	50.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	52.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	53.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	59.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	67.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	75.0	%	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	Activity	76.0	%	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	Activity	123.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	124.0	%	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	Activity	127.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	206.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	243.0	%	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	Activity	251.0	%	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	Activity	nan	None	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	FC	1.3	None	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	FC	1.4	None	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	FC	1.5	None	10.1016/j.bmcl.2015.04.080
Cricetinae	Hamster	FC	3.0	None	10.1016/j.bmcl.2015.01.047
Cricetinae	Hamster	FC	3.4	None	10.1016/j.bmcl.2015.04.080
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	188.7	nM	None
Homo sapiens	Alpha-synuclein	Potency	35481.3	nM	None
Homo sapiens	Androgen Receptor	Potency	44668.4	nM	None
Homo sapiens	Ataxin-2	Potency	22387.2	nM	None
Homo sapiens	Bile acid receptor FXR	Activity	2.05	None	10.1016/j.bmcl.2006.05.084
Homo sapiens	Bile acid receptor FXR	EC50	1000.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	Bile acid receptor FXR	EC50	1300.0	nM	10.1021/jm401901d
Homo sapiens	Bile acid receptor FXR	EC50	3400.0	nM	10.1016/j.bmcl.2016.02.031
Homo sapiens	Bile acid receptor FXR	EC50	5000.0	nM	None
Homo sapiens	Bile acid receptor FXR	FC	77.0	None	10.1016/j.bmcl.2013.10.054
Homo sapiens	Bile acid receptor FXR	IC50	5300.0	nM	10.1021/acs.jmedchem.9b00327
Homo sapiens	Bile acid receptor FXR	Potency	1778.3	nM	None
Homo sapiens	Bile acid receptor FXR	Potency	44668.4	nM	None
Homo sapiens	Bromodomain-containing protein 4	Delta TM	-2.49	C	None
Homo sapiens	Bromodomain-containing protein 4	Delta TM	-1.421	C	None
Homo sapiens	Casein kinase I delta	Delta TM	0.1	C	None
Homo sapiens	Casein kinase I delta	Delta TM	0.2167	C	None
Homo sapiens	Cyclin-dependent kinase 2	Delta TM	-1.358	C	None
Homo sapiens	Cyclin-dependent kinase 2	Delta TM	-0.3	C	None
Homo sapiens	Dihydroorotate dehydrogenase	IC50	nan	None	10.1021/acs.jmedchem.1c01746
Homo sapiens	DNA polymerase iota	Potency	79432.8	nM	None
Homo sapiens	DNA polymerase kappa	Potency	35481.3	nM	None
Homo sapiens	Estrogen receptor alpha	Potency	44668.4	nM	None
Homo sapiens	Fibroblast	Control DMSO Fragmented Nuclei %	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Fragmented Nuclei %	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Fragmented Nuclei %	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Fragmented Nuclei %	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Fragmented Nuclei %	18.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	60.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	62.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	67.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	68.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	69.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	70.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Healthy Nuclei (%)	72.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Membrane Permeable-Phenotype Cells (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Membrane Permeable-Phenotype Cells (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Membrane Permeable-Phenotype Cells (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Membrane Permeable-Phenotype Cells (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitochondria Different-Phenotype Cells (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitochondria Different-Phenotype Cells (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitochondria Different-Phenotype Cells (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitotic Cells (%)	31.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitotic Cells (%)	37.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitotic Cells (%)	49.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitotic Cells (%)	56.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitotic Cells (%)	59.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitotic Cells (%)	61.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Mitotic Cells (%)	62.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Pyknosed Nuclei (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Pyknosed Nuclei (%)	16.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Pyknosed Nuclei (%)	20.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Pyknosed Nuclei (%)	21.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Pyknosed Nuclei (%)	22.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	127.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	131.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	198.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	199.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	205.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	208.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	212.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Total Cells	216.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Tubulin Phenotype Different Cells (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Tubulin Phenotype Different Cells (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Tubulin Phenotype Different Cells (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Tubulin Phenotype Different Cells (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Tubulin Phenotype Different Cells (%)	9.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Tubulin Phenotype Different Cells (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Control DMSO Tubulin Phenotype Different Cells (%)	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Growth Rate	-0.32	None	10.6019/CHEMBL5058564
Homo sapiens	Fibroblast	Growth Rate	-0.3	None	10.6019/CHEMBL5058564
Homo sapiens	Fibroblast	Growth Rate	-0.09	None	10.6019/CHEMBL5058564
Homo sapiens	Fibroblast	Growth Rate	0.0	None	10.6019/CHEMBL4689842
Homo sapiens	Fibroblast	Growth Rate	0.05	None	10.6019/CHEMBL5058564
Homo sapiens	Fibroblast	Growth Rate	0.22	None	10.6019/CHEMBL5058564
Homo sapiens	Fibroblast	Growth Rate	0.72	None	10.6019/CHEMBL5058564
Homo sapiens	Fibroblast	Population Apoptotic (%)	27.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	28.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	30.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	33.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	37.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	43.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	45.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	50.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	52.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	63.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	69.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	71.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	75.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Apoptotic (%)	78.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	16.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	18.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	19.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	25.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	26.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Fragmented Nuclei (%)	30.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	46.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	47.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	50.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	54.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	57.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	58.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	60.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	67.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Healthy Nuclei (%)	68.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Hoechst High Intensity Objects (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Hoechst High Intensity Objects (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	16.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	17.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Membrane Permeable-Phenotype (%)	26.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	22.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitochondria Different-Phenotype (%)	25.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	21.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	24.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	28.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	30.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	33.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	36.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	47.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	50.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	54.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	56.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	62.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	69.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	71.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Mitotic Cells (%)	72.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Normal (%)	98.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Normal (%)	99.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Normal (%)	100.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	19.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	20.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	21.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	24.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	25.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	27.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	28.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	29.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	31.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Pyknosed Nuclei (%)	35.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	21.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	24.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	28.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	32.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	34.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	40.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	56.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	65.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	69.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Population Tubulin-Different-Phenotype (%)	80.0	%	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	92.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	98.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	101.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	108.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	128.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	132.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	134.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	135.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	143.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	145.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	151.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	175.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	204.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast	Total Cell Count	214.0	None	10.6019/CHEMBL5303300
Homo sapiens	Fibroblast growth factor receptor 3	Delta TM	-0.1921	C	None
Homo sapiens	Fibroblast growth factor receptor 3	Delta TM	-0.13	C	None
Homo sapiens	Gamma-secretase	EC50	3600.0	nM	10.1016/j.bmcl.2007.07.044
Homo sapiens	Gamma-secretase	IC50	4500.0	nM	10.1016/j.bmcl.2007.07.044
Homo sapiens	Gamma-secretase	IC50	40000.0	nM	10.1016/j.bmcl.2007.07.044
Homo sapiens	Glucagon-like peptide 1 receptor	Potency	11220.2	nM	None
Homo sapiens	Glucocorticoid receptor	Potency	39810.7	nM	None
Homo sapiens	Glycogen synthase kinase-3 beta	Delta TM	-0.4	C	None
Homo sapiens	Glycogen synthase kinase-3 beta	Delta TM	0.4668	C	None
Homo sapiens	Glycogen synthase kinase-3 beta	IC50	nan	nM	10.1021/jm050532w
Homo sapiens	HEK-293T	Control DMSO Fragmented Nuclei %	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Fragmented Nuclei %	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Fragmented Nuclei %	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Fragmented Nuclei %	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Healthy Nuclei (%)	69.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Healthy Nuclei (%)	70.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Healthy Nuclei (%)	82.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Healthy Nuclei (%)	84.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Healthy Nuclei (%)	85.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Healthy Nuclei (%)	86.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Membrane Permeable-Phenotype Cells (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Membrane Permeable-Phenotype Cells (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Membrane Permeable-Phenotype Cells (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Membrane Permeable-Phenotype Cells (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Membrane Permeable-Phenotype Cells (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitochondria Different-Phenotype Cells (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitochondria Different-Phenotype Cells (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitochondria Different-Phenotype Cells (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitochondria Different-Phenotype Cells (%)	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitochondria Different-Phenotype Cells (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitochondria Different-Phenotype Cells (%)	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitochondria Different-Phenotype Cells (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitotic Cells (%)	49.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitotic Cells (%)	54.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitotic Cells (%)	57.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitotic Cells (%)	60.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitotic Cells (%)	62.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitotic Cells (%)	81.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Mitotic Cells (%)	85.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Pyknosed Nuclei (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Pyknosed Nuclei (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Pyknosed Nuclei (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Pyknosed Nuclei (%)	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Pyknosed Nuclei (%)	26.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	364.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	370.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	680.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	681.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	1046.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	1069.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	2439.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Total Cells	2812.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	25.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	27.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	47.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Control DMSO Tubulin Phenotype Different Cells (%)	48.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Growth Rate	0.0	None	10.6019/CHEMBL4689842
Homo sapiens	HEK-293T	Growth Rate	0.24	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	0.37	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	0.42	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	0.53	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	0.56	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	0.75	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	0.77	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	0.85	None	10.6019/CHEMBL5058564
Homo sapiens	HEK-293T	Growth Rate	1.0	None	10.6019/CHEMBL4689842
Homo sapiens	HEK-293T	Population Apoptotic (%)	9.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	28.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	31.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	36.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	39.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	40.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	42.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	44.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	48.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	54.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	56.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	57.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	67.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	68.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Apoptotic (%)	74.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Fragmented Nuclei (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	68.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	72.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	75.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	78.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	79.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	80.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	81.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	82.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	83.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	84.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	85.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Healthy Nuclei (%)	87.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	9.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	18.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Hoechst High Intensity Objects (%)	24.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Membrane Permeable-Phenotype (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Membrane Permeable-Phenotype (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Membrane Permeable-Phenotype (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Membrane Permeable-Phenotype (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Membrane Permeable-Phenotype (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Membrane Permeable-Phenotype (%)	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	9.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	22.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	42.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	49.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	53.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	58.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	59.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitochondria Different-Phenotype (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	25.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	31.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	32.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	42.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	43.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	45.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	51.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	55.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	57.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	59.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	60.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	63.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	68.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	71.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Mitotic Cells (%)	90.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	75.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	81.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	84.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	85.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	89.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	90.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	91.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	92.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	94.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	95.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Normal (%)	96.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	19.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	24.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	27.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Pyknosed Nuclei (%)	28.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	16.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	19.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	22.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	36.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	38.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	56.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	81.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	82.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	86.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	87.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Population Tubulin-Different-Phenotype (%)	94.0	%	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	264.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	279.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	296.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	318.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	373.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	376.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	385.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	411.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	426.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	429.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	522.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	697.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	740.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	1214.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	1428.0	None	10.6019/CHEMBL5303300
Homo sapiens	HEK-293T	Total Cell Count	2956.0	None	10.6019/CHEMBL5303300
Homo sapiens	Hepatocyte	Activity	nan	None	10.1021/jm070453f
Homo sapiens	HepG2	Activity	100.0	%	10.1016/j.bmcl.2007.11.013
Homo sapiens	HepG2	Activity	100.0	%	10.1016/j.bmcl.2010.03.031
Homo sapiens	HepG2	Activity	175.0	%	10.1021/jm301913k
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.bmcl.2012.04.071
Homo sapiens	HepG2	Activity	nan	None	10.1021/jm301913k
Homo sapiens	HepG2	EC50	61.0	nM	10.1021/jm800799q
Homo sapiens	HepG2	EC50	67.0	nM	10.1016/j.bmcl.2007.11.013
Homo sapiens	HepG2	EC50	104.0	nM	10.1016/j.bmcl.2009.11.099
Homo sapiens	HepG2	EC50	107.0	nM	10.1016/j.bmcl.2010.03.031
Homo sapiens	HepG2	EC50	137.0	nM	10.1016/j.bmcl.2009.11.062
Homo sapiens	HepG2	EC50	137.0	nM	10.1016/j.bmcl.2009.11.098
Homo sapiens	HepG2	EC50	137.0	nM	10.1021/jm800799q
Homo sapiens	HepG2	EC50	140.0	nM	10.1021/jm100034x
Homo sapiens	HepG2	Efficacy	100.0	%	10.1016/j.bmcl.2009.11.098
Homo sapiens	HepG2	Efficacy	100.0	%	10.1016/j.bmcl.2009.11.099
Homo sapiens	HepG2	Efficacy	100.0	%	10.1021/jm800799q
Homo sapiens	HepG2	IC50 relative	13400.0	nM	10.6019/EOS300108
Homo sapiens	HepG2	Potency	22387.2	nM	None
Homo sapiens	HepG2	Potency	35481.3	nM	None
Homo sapiens	HepG2	Ratio	3.6	None	10.1016/j.bmcl.2007.03.076
Homo sapiens	HepG2	Ratio	3.6	None	10.1016/j.bmcl.2007.06.017
Homo sapiens	HepG2	Ratio	6.7	None	10.1016/j.bmcl.2007.06.017
Homo sapiens	Histone deacetylase 6	Inhibition	2.06	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	3.04	%	10.6019/CHEMBL4808148
Homo sapiens	Huh-7	Activity	1.0	None	10.1021/jm800612u
Homo sapiens	Huh-7	Activity	100.0	%	10.1016/j.bmcl.2010.03.031
Homo sapiens	Huh-7	EC50	36.0	nM	10.1016/j.bmcl.2010.03.031
Homo sapiens	Huh-7	EC50	67.0	nM	10.1016/j.bmc.2009.04.012
Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic	Potency	23109.3	nM	None
Homo sapiens	Liver microsomes	T1/2	0.5	hr	10.1016/j.bmcl.2009.10.132
Homo sapiens	Liver microsomes	T1/2	0.5	hr	10.1016/j.bmcl.2009.11.098
Homo sapiens	Liver microsomes	T1/2	0.5	hr	10.1016/j.bmcl.2010.03.031
Homo sapiens	Liver X receptor	Activity	-11.0	%	10.1016/j.bmcl.2013.05.030
Homo sapiens	Liver X receptor	Activity	99.0	%	10.1016/j.bmcl.2007.11.013
Homo sapiens	Liver X receptor	Activity	nan	None	10.1016/j.bmc.2013.10.024
Homo sapiens	Liver X receptor	Activity	nan	None	10.1016/j.bmcl.2012.04.071
Homo sapiens	Liver X receptor	Activity	nan	None	10.1016/j.ejmech.2014.01.003
Homo sapiens	Liver X receptor	EC50	17.0	nM	10.1016/j.bmcl.2014.11.029
Homo sapiens	Liver X receptor	EC50	137.0	nM	10.1016/j.bmcl.2007.11.013
Homo sapiens	Liver X receptor	EC50	170.0	nM	10.1016/j.bmcl.2009.10.132
Homo sapiens	Liver X receptor	Efficacy	89.0	%	10.1016/j.bmcl.2014.11.029
Homo sapiens	Liver X receptor	Efficacy	100.0	%	10.1016/j.bmcl.2009.10.132
Homo sapiens	Liver X receptor	FC	0.6	None	10.1021/jm3002394
Homo sapiens	Liver X receptor	FC	2.6	None	10.1016/j.bmcl.2013.05.030
Homo sapiens	Liver X receptor	FC	2.621	None	10.1016/j.bmcl.2018.12.025
Homo sapiens	Liver X receptor	FC	3.2	None	10.1016/j.bmcl.2013.05.030
Homo sapiens	Liver X receptor	FC	4.82	None	10.1021/acs.jmedchem.5b02029
Homo sapiens	Liver X receptor	FC	5.38	None	10.1021/acs.jmedchem.5b02029
Homo sapiens	Liver X receptor	FC	8.6	None	10.1016/j.bmcl.2013.05.030
Homo sapiens	Liver X receptor	FC	8.95	None	10.1016/j.bmcl.2018.12.025
Homo sapiens	Liver X receptor	FC	18.1	None	10.1016/j.bmcl.2013.05.030
Homo sapiens	Liver X receptor	IC50	10000.0	nM	10.1021/jm3002394
Homo sapiens	Liver X receptor	IC50	26000.0	nM	10.1021/acsmedchemlett.5b00170
Homo sapiens	Liver X receptor	Inhibition	49.0	%	10.1021/jm3002394
Homo sapiens	Liver X receptor (LXR alpha AND LXR beta)	Ratio IC50	1.0	None	10.1016/j.bmcl.2009.11.062
Homo sapiens	Liver X receptor (LXR alpha AND LXR beta)	Ratio IC50	1.0	None	10.1016/j.bmcl.2009.11.099
Homo sapiens	Liver X receptor (LXR alpha AND LXR beta)	Ratio IC50	1.4	None	10.1016/j.bmc.2009.04.012
Homo sapiens	Liver X receptor (LXR alpha AND LXR beta)	Ratio IC50	1.4	None	10.1016/j.bmcl.2007.11.013
Homo sapiens	LXR-alpha	Activity	96.0	%	10.1016/j.bmcl.2013.05.030
Homo sapiens	LXR-alpha	Activity	100.0	%	10.1016/j.bmcl.2007.11.013
Homo sapiens	LXR-alpha	Activity	nan	None	10.1016/j.bmcl.2012.04.071
Homo sapiens	LXR-alpha	Activity	nan	None	10.1016/j.bmcl.2017.12.024
Homo sapiens	LXR-alpha	Activity	nan	None	10.1021/jm100034x
Homo sapiens	LXR-alpha	Activity	nan	None	10.1021/jm3002394
Homo sapiens	LXR-alpha	EC50	3.2	nM	10.1021/jm101063h
Homo sapiens	LXR-alpha	EC50	6.0	nM	10.1016/j.bmcl.2017.12.024
Homo sapiens	LXR-alpha	EC50	10.0	nM	10.1016/j.bmcl.2005.12.015
Homo sapiens	LXR-alpha	EC50	10.0	nM	10.1016/j.bmcl.2009.02.039
Homo sapiens	LXR-alpha	EC50	20.0	nM	10.1021/acs.jmedchem.6b00176
Homo sapiens	LXR-alpha	EC50	28.0	nM	10.1016/j.bmcl.2014.11.029
Homo sapiens	LXR-alpha	EC50	30.0	nM	10.1016/j.bmcl.2015.07.047
Homo sapiens	LXR-alpha	EC50	40.0	nM	10.1016/j.bmcl.2007.03.076
Homo sapiens	LXR-alpha	EC50	40.0	nM	10.1016/j.bmcl.2007.06.017
Homo sapiens	LXR-alpha	EC50	50.0	nM	10.1021/acs.jmedchem.8b01848
Homo sapiens	LXR-alpha	EC50	55.0	nM	10.1021/jm050532w
Homo sapiens	LXR-alpha	EC50	60.0	nM	10.1021/jm0255116
Homo sapiens	LXR-alpha	EC50	63.1	nM	10.1021/jm901797p
Homo sapiens	LXR-alpha	EC50	85.0	nM	10.1016/j.bmcl.2009.02.039
Homo sapiens	LXR-alpha	EC50	85.0	nM	10.1021/jm0255116
Homo sapiens	LXR-alpha	EC50	91.1	nM	10.1016/j.bmcl.2013.05.030
Homo sapiens	LXR-alpha	EC50	120.0	nM	10.1039/C9MD00264B
Homo sapiens	LXR-alpha	EC50	135.0	nM	10.1016/j.bmc.2009.04.012
Homo sapiens	LXR-alpha	EC50	135.0	nM	10.1016/j.bmcl.2007.11.013
Homo sapiens	LXR-alpha	EC50	140.0	nM	10.1016/j.bmcl.2009.11.062
Homo sapiens	LXR-alpha	EC50	140.0	nM	10.1021/jm800799q
Homo sapiens	LXR-alpha	EC50	170.0	nM	10.1016/j.bmcl.2009.11.098
Homo sapiens	LXR-alpha	EC50	190.0	nM	10.1007/s00044-012-0359-5
Homo sapiens	LXR-alpha	EC50	210.0	nM	10.1021/acsmedchemlett.5b00170
Homo sapiens	LXR-alpha	EC50	250.0	nM	10.1016/j.bmcl.2006.06.081
Homo sapiens	LXR-alpha	EC50	250.0	nM	10.1039/C3MD00005B
Homo sapiens	LXR-alpha	EC50	260.0	nM	10.1016/j.bmc.2022.116792
Homo sapiens	LXR-alpha	EC50	290.0	nM	10.1016/j.bmc.2014.03.007
Homo sapiens	LXR-alpha	EC50	340.0	nM	10.1021/jm3002394
Homo sapiens	LXR-alpha	EC50	359.0	nM	10.1016/j.bmcl.2017.12.006
Homo sapiens	LXR-alpha	EC50	370.0	nM	10.1021/jm401901d
Homo sapiens	LXR-alpha	EC50	373.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	LXR-alpha	EC50	400.0	nM	10.1016/j.bmcl.2016.02.031
Homo sapiens	LXR-alpha	EC50	490.0	nM	10.1016/j.bmc.2016.05.048
Homo sapiens	LXR-alpha	EC50	490.0	nM	10.1016/j.bmcl.2015.01.047
Homo sapiens	LXR-alpha	EC50	500.0	nM	10.1016/j.bmcl.2015.04.080
Homo sapiens	LXR-alpha	EC50	530.0	nM	10.1021/acs.jnatprod.9b00055
Homo sapiens	LXR-alpha	EC50	940.0	nM	10.1016/j.bmcl.2017.01.066
Homo sapiens	LXR-alpha	EC50	1430.0	nM	10.1016/j.bmcl.2012.04.071
Homo sapiens	LXR-alpha	Efficacy	100.0	%	10.1016/j.bmcl.2014.11.029
Homo sapiens	LXR-alpha	Efficacy	100.0	%	10.1021/jm800799q
Homo sapiens	LXR-alpha	Efficacy	124.0	%	10.1021/jm3002394
Homo sapiens	LXR-alpha	Emax	100.0	%	10.1016/j.bmc.2016.05.048
Homo sapiens	LXR-alpha	Emax	100.0	%	10.1016/j.bmcl.2015.01.047
Homo sapiens	LXR-alpha	Emax	100.0	%	10.1016/j.bmcl.2015.04.080
Homo sapiens	LXR-alpha	Emax	100.0	%	10.1021/acs.jmedchem.6b00176
Homo sapiens	LXR-alpha	FC	0.66	None	10.1007/s00044-012-0359-5
Homo sapiens	LXR-alpha	FC	2.2	None	10.1007/s00044-012-0359-5
Homo sapiens	LXR-alpha	FC	2.6	None	10.1007/s00044-012-0359-5
Homo sapiens	LXR-alpha	FC	2.61	None	10.1007/s00044-012-0359-5
Homo sapiens	LXR-alpha	FC	19.3	None	10.1021/acs.jnatprod.9b00055
Homo sapiens	LXR-alpha	FC	643.0	None	10.1016/j.bmcl.2013.10.054
Homo sapiens	LXR-alpha	IC50	9.0	nM	10.1016/j.bmcl.2009.10.132
Homo sapiens	LXR-alpha	IC50	9.0	nM	10.1016/j.bmcl.2009.11.098
Homo sapiens	LXR-alpha	IC50	9.0	nM	10.1016/j.bmcl.2009.11.099
Homo sapiens	LXR-alpha	IC50	10.0	nM	10.1021/jm0609566
Homo sapiens	LXR-alpha	IC50	13.0	nM	10.1016/j.bmc.2009.10.001
Homo sapiens	LXR-alpha	IC50	13.0	nM	10.1016/j.bmcl.2007.11.013
Homo sapiens	LXR-alpha	IC50	13.0	nM	10.1016/j.bmcl.2009.11.062
Homo sapiens	LXR-alpha	IC50	13.0	nM	10.1016/j.bmcl.2010.03.031
Homo sapiens	LXR-alpha	IC50	13.0	nM	10.1021/jm100034x
Homo sapiens	LXR-alpha	IC50	13.0	nM	10.1021/jm800799q
Homo sapiens	LXR-alpha	IC50	30.0	nM	10.1016/j.bmcl.2006.06.081
Homo sapiens	LXR-alpha	IC50	50.0	nM	10.1021/acs.jmedchem.9b00327
Homo sapiens	LXR-alpha	IC50	75.0	nM	10.1021/jm800612u
Homo sapiens	LXR-alpha	IC50	100.0	nM	10.1016/j.bmcl.2012.02.028
Homo sapiens	LXR-alpha	IC50	14000.0	nM	10.1016/j.bmc.2009.04.012
Homo sapiens	LXR-alpha	IC50	nan	None	10.1016/j.bmc.2014.03.007
Homo sapiens	LXR-alpha	IC50	nan	None	10.1021/acsmedchemlett.5b00170
Homo sapiens	LXR-alpha	IC50	nan	None	10.1021/jm3002394
Homo sapiens	LXR-alpha	Kd	92.4	nM	10.1016/j.bmcl.2013.05.030
Homo sapiens	LXR-alpha	Ki	24.0	nM	10.1016/j.bmcl.2016.08.089
Homo sapiens	LXR-alpha	%max	90.0	%	10.1016/j.bmcl.2017.12.006
Homo sapiens	LXR-alpha	max activation	6.1	%	10.1016/j.bmcl.2005.12.015
Homo sapiens	LXR-alpha	Ratio	1.1	None	10.1021/jm901797p
Homo sapiens	LXR-alpha	RE	0.8	None	10.1021/jm050532w
Homo sapiens	LXR-alpha	RE	1.0	None	10.1021/jm0255116
Homo sapiens	LXR-alpha	RE	1.1	None	10.1021/jm050532w
Homo sapiens	LXR-alpha	RE	2.5	None	10.1021/jm0255116
Homo sapiens	LXR-beta	Activity	45.0	%	10.1016/j.bmcl.2013.05.030
Homo sapiens	LXR-beta	Activity	100.0	%	10.1016/j.bmc.2006.12.026
Homo sapiens	LXR-beta	Activity	100.0	%	10.1016/j.bmcl.2007.11.013
Homo sapiens	LXR-beta	Activity	100.0	%	10.1016/j.bmcl.2010.03.031
Homo sapiens	LXR-beta	Activity	nan	None	10.1016/j.bmcl.2012.04.071
Homo sapiens	LXR-beta	Activity	nan	None	10.1021/jm100034x
Homo sapiens	LXR-beta	Activity	nan	None	10.1021/jm800612u
Homo sapiens	LXR-beta	EC50	4.7	nM	10.1021/jm101063h
Homo sapiens	LXR-beta	EC50	8.0	nM	10.1016/j.bmcl.2009.02.039
Homo sapiens	LXR-beta	EC50	10.0	nM	10.1021/acs.jmedchem.6b01126
Homo sapiens	LXR-beta	EC50	11.0	nM	10.1016/j.bmcl.2007.03.076
Homo sapiens	LXR-beta	EC50	11.0	nM	10.1016/j.bmcl.2007.06.017
Homo sapiens	LXR-beta	EC50	15.0	nM	10.1016/j.bmcl.2007.03.076
Homo sapiens	LXR-beta	EC50	15.0	nM	10.1016/j.bmcl.2007.06.017
Homo sapiens	LXR-beta	EC50	16.0	nM	10.1016/j.bmc.2009.10.001
Homo sapiens	LXR-beta	EC50	16.0	nM	10.1021/jm0609566
Homo sapiens	LXR-beta	EC50	19.0	nM	10.1021/jm100034x
Homo sapiens	LXR-beta	EC50	20.0	nM	10.1021/acs.jmedchem.6b00176
Homo sapiens	LXR-beta	EC50	21.0	nM	10.1016/j.bmcl.2017.12.024
Homo sapiens	LXR-beta	EC50	30.0	nM	10.1021/jm050532w
Homo sapiens	LXR-beta	EC50	50.0	nM	10.1021/acs.jmedchem.8b01848
Homo sapiens	LXR-beta	EC50	53.0	nM	10.1021/jm100034x
Homo sapiens	LXR-beta	EC50	60.0	nM	10.1039/C9MD00264B
Homo sapiens	LXR-beta	EC50	66.0	nM	10.1021/acsmedchemlett.5b00170
Homo sapiens	LXR-beta	EC50	75.0	nM	10.1016/j.bmcl.2009.02.039
Homo sapiens	LXR-beta	EC50	84.0	%	10.1016/j.bmcl.2007.06.017
Homo sapiens	LXR-beta	EC50	85.0	nM	10.1016/j.bmcl.2014.09.053
Homo sapiens	LXR-beta	EC50	90.0	nM	10.1021/jm3002394
Homo sapiens	LXR-beta	EC50	100.0	nM	10.1016/j.bmc.2006.12.026
Homo sapiens	LXR-beta	EC50	100.0	nM	10.1021/jm901797p
Homo sapiens	LXR-beta	EC50	102.6	nM	10.1016/j.bmcl.2013.05.030
Homo sapiens	LXR-beta	EC50	110.0	nM	10.1016/j.bmcl.2012.04.071
Homo sapiens	LXR-beta	EC50	120.0	nM	10.1016/j.bmc.2014.03.007
Homo sapiens	LXR-beta	EC50	130.0	nM	10.1016/j.bmcl.2015.07.047
Homo sapiens	LXR-beta	EC50	135.0	nM	10.1016/j.bmcl.2009.11.098
Homo sapiens	LXR-beta	EC50	140.0	nM	10.1016/j.bmcl.2014.11.029
Homo sapiens	LXR-beta	EC50	140.0	nM	10.1021/jm100034x
Homo sapiens	LXR-beta	EC50	156.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	LXR-beta	EC50	160.0	nM	10.1021/jm401901d
Homo sapiens	LXR-beta	EC50	170.0	nM	10.1016/j.bmcl.2009.11.062
Homo sapiens	LXR-beta	EC50	170.0	nM	10.1016/j.bmcl.2010.03.031
Homo sapiens	LXR-beta	EC50	170.0	nM	10.1021/jm100034x
Homo sapiens	LXR-beta	EC50	170.0	nM	10.1021/jm800799q
Homo sapiens	LXR-beta	EC50	178.0	nM	10.1016/j.bmc.2009.04.012
Homo sapiens	LXR-beta	EC50	178.0	nM	10.1016/j.bmcl.2007.11.013
Homo sapiens	LXR-beta	EC50	198.0	nM	10.1016/j.bmcl.2017.12.006
Homo sapiens	LXR-beta	EC50	230.0	nM	10.1016/j.bmcl.2016.02.031
Homo sapiens	LXR-beta	EC50	252.0	nM	None
Homo sapiens	LXR-beta	EC50	260.0	nM	10.1016/j.bmc.2022.116792
Homo sapiens	LXR-beta	EC50	300.0	nM	10.1016/j.bmcl.2006.06.081
Homo sapiens	LXR-beta	EC50	400.0	nM	10.1016/j.bmcl.2015.04.080
Homo sapiens	LXR-beta	EC50	410.0	nM	10.1016/j.bmc.2016.05.048
Homo sapiens	LXR-beta	EC50	410.0	nM	10.1016/j.bmcl.2015.01.047
Homo sapiens	LXR-beta	EC50	800.0	nM	10.1016/j.bmcl.2017.01.066
Homo sapiens	LXR-beta	Efficacy	100.0	%	10.1021/jm800799q
Homo sapiens	LXR-beta	Efficacy	118.0	%	10.1021/jm3002394
Homo sapiens	LXR-beta	Efficacy	140.0	%	10.1016/j.bmcl.2014.11.029
Homo sapiens	LXR-beta	Emax	100.0	%	10.1016/j.bmc.2016.05.048
Homo sapiens	LXR-beta	Emax	100.0	%	10.1016/j.bmcl.2015.01.047
Homo sapiens	LXR-beta	Emax	100.0	%	10.1016/j.bmcl.2015.04.080
Homo sapiens	LXR-beta	Emax	100.0	%	10.1021/acs.jmedchem.6b00176
Homo sapiens	LXR-beta	FC	1.6	None	10.1007/s00044-012-0359-5
Homo sapiens	LXR-beta	FC	284.0	None	10.1016/j.bmcl.2013.10.054
Homo sapiens	LXR-beta	IC50	9.0	nM	10.1016/j.bmc.2009.10.001
Homo sapiens	LXR-beta	IC50	9.0	nM	10.1016/j.bmcl.2007.11.013
Homo sapiens	LXR-beta	IC50	9.0	nM	10.1016/j.bmcl.2009.11.062
Homo sapiens	LXR-beta	IC50	9.0	nM	10.1016/j.bmcl.2010.03.031
Homo sapiens	LXR-beta	IC50	9.0	nM	10.1021/jm100034x
Homo sapiens	LXR-beta	IC50	9.0	nM	10.1021/jm800799q
Homo sapiens	LXR-beta	IC50	10.0	nM	10.1021/jm0609566
Homo sapiens	LXR-beta	IC50	13.0	nM	10.1016/j.bmcl.2009.10.132
Homo sapiens	LXR-beta	IC50	13.0	nM	10.1016/j.bmcl.2009.11.098
Homo sapiens	LXR-beta	IC50	13.0	nM	10.1016/j.bmcl.2009.11.099
Homo sapiens	LXR-beta	IC50	19.95	nM	10.1021/jm901797p
Homo sapiens	LXR-beta	IC50	30.0	nM	10.1021/jm800612u
Homo sapiens	LXR-beta	IC50	70.0	nM	10.1016/j.bmcl.2006.06.081
Homo sapiens	LXR-beta	IC50	100.0	nM	10.1016/j.bmcl.2012.02.028
Homo sapiens	LXR-beta	IC50	9000.0	nM	10.1016/j.bmc.2009.04.012
Homo sapiens	LXR-beta	IC50	nan	None	10.1016/j.bmc.2014.03.007
Homo sapiens	LXR-beta	IC50	nan	None	10.1021/acsmedchemlett.5b00170
Homo sapiens	LXR-beta	IC50	nan	None	10.1021/jm3002394
Homo sapiens	LXR-beta	Kd	103.0	nM	10.1016/j.bmcl.2013.05.030
Homo sapiens	LXR-beta	Ki	17.0	nM	10.1016/j.bmcl.2016.08.089
Homo sapiens	LXR-beta	Ki	41.3	nM	10.1016/j.ejmech.2019.06.011
Homo sapiens	LXR-beta	Ki	41.3	nM	10.1016/j.ejmech.2020.112240
Homo sapiens	LXR-beta	%max	100.0	%	10.1016/j.bmcl.2017.12.006
Homo sapiens	LXR-beta	Ratio	1.1	None	10.1021/jm901797p
Homo sapiens	MAP kinase ERK2	Delta TM	-0.3422	C	None
Homo sapiens	MAP kinase ERK2	Delta TM	0.03	C	None
Homo sapiens	Microtubule-associated protein tau	Potency	631.0	nM	None
Homo sapiens	Mothers against decapentaplegic homolog 3	Potency	22387.2	nM	None
Homo sapiens	Mothers against decapentaplegic homolog 3	Potency	35481.3	nM	None
Homo sapiens	Niemann-Pick C1 protein	Activity	nan	None	10.1016/j.bmcl.2017.04.062
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	27306.0	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	86349.2	nM	None
Homo sapiens	Nuclear factor NF-kappa-B p105 subunit	Potency	50118.7	nM	None
Homo sapiens	Nuclear receptor ROR-alpha	EC50	5000.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	Nuclear receptor ROR-alpha	EC50	5000.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-alpha	IC50	2000.0	nM	10.1021/acs.jmedchem.8b00588
Homo sapiens	Nuclear receptor ROR-alpha	IC50	2000.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-alpha	IC50	2000.0	nM	10.1039/C3MD00005B
Homo sapiens	Nuclear receptor ROR-alpha	IC50	2000.0	nM	None
Homo sapiens	Nuclear receptor ROR-alpha	IC50	2600.0	nM	10.1021/acs.jmedchem.9b00327
Homo sapiens	Nuclear receptor ROR-alpha	IC50	5011.87	nM	10.1016/j.bmcl.2014.09.053
Homo sapiens	Nuclear receptor ROR-alpha	IC50	11000.0	nM	10.1016/j.bmc.2018.07.038
Homo sapiens	Nuclear receptor ROR-alpha	IC50	20000.0	nM	10.1016/j.bmc.2014.03.007
Homo sapiens	Nuclear receptor ROR-alpha	IC50	nan	None	10.1016/j.bmcl.2016.02.031
Homo sapiens	Nuclear receptor ROR-alpha	Ki	132.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-alpha	Ki	132.0	nM	10.1039/C3MD00005B
Homo sapiens	Nuclear receptor ROR-alpha	%max	55.0	%	10.1021/acs.jmedchem.9b00327
Homo sapiens	Nuclear receptor ROR-beta	EC50	6000.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	Nuclear receptor ROR-beta	EC50	6000.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-beta	Efficacy	55.0	%	10.1016/j.bmcl.2014.09.053
Homo sapiens	Nuclear receptor ROR-beta	IC50	5011.87	nM	10.1016/j.bmcl.2014.09.053
Homo sapiens	Nuclear receptor ROR-beta	IC50	10000.0	nM	10.1016/j.bmcl.2014.09.053
Homo sapiens	Nuclear receptor ROR-beta	IC50	nan	None	10.1016/j.bmc.2014.03.007
Homo sapiens	Nuclear receptor ROR-beta	IC50	nan	None	10.1016/j.bmcl.2016.02.031
Homo sapiens	Nuclear receptor ROR-beta	IC50	nan	None	10.1021/acs.jmedchem.9b00327
Homo sapiens	Nuclear receptor ROR-gamma	EC50	54.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	Nuclear receptor ROR-gamma	EC50	54.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-gamma	EC50	333.0	nM	10.1016/j.bmcl.2017.12.006
Homo sapiens	Nuclear receptor ROR-gamma	EC50	460.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-gamma	EC50	463.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	Nuclear receptor ROR-gamma	Efficacy	-99.0	%	10.1016/j.bmcl.2013.10.054
Homo sapiens	Nuclear receptor ROR-gamma	Efficacy	100.0	%	10.1016/j.bmcl.2014.09.053
Homo sapiens	Nuclear receptor ROR-gamma	IC50	60.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	Nuclear receptor ROR-gamma	IC50	60.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-gamma	IC50	204.0	nM	10.1016/j.bmcl.2016.03.109
Homo sapiens	Nuclear receptor ROR-gamma	IC50	238.0	nM	10.1021/acs.jmedchem.1c01746
Homo sapiens	Nuclear receptor ROR-gamma	IC50	316.23	nM	10.1016/j.bmcl.2014.09.053
Homo sapiens	Nuclear receptor ROR-gamma	IC50	330.0	nM	10.1021/acs.jmedchem.9b00327
Homo sapiens	Nuclear receptor ROR-gamma	IC50	501.19	nM	10.1016/j.bmcl.2014.09.053
Homo sapiens	Nuclear receptor ROR-gamma	IC50	540.0	nM	10.1016/j.ejmech.2014.03.065
Homo sapiens	Nuclear receptor ROR-gamma	IC50	810.0	nM	10.1021/acs.jmedchem.1c01746
Homo sapiens	Nuclear receptor ROR-gamma	IC50	1700.0	nM	10.1021/acs.jmedchem.8b00588
Homo sapiens	Nuclear receptor ROR-gamma	IC50	1700.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-gamma	IC50	1700.0	nM	10.1039/C3MD00005B
Homo sapiens	Nuclear receptor ROR-gamma	IC50	1730.0	nM	None
Homo sapiens	Nuclear receptor ROR-gamma	IC50	2010.0	nM	10.1016/j.ejmech.2014.03.065
Homo sapiens	Nuclear receptor ROR-gamma	IC50	3000.0	nM	10.1016/j.bmcl.2016.02.031
Homo sapiens	Nuclear receptor ROR-gamma	IC50	3500.0	nM	10.1016/j.ejmech.2014.03.065
Homo sapiens	Nuclear receptor ROR-gamma	IC50	4400.0	nM	10.1016/j.bmc.2018.07.038
Homo sapiens	Nuclear receptor ROR-gamma	IC50	6500.0	nM	10.1016/j.bmc.2014.03.007
Homo sapiens	Nuclear receptor ROR-gamma	Imax	76.0	%	10.1016/j.ejmech.2014.03.065
Homo sapiens	Nuclear receptor ROR-gamma	Imax	82.0	%	10.1016/j.ejmech.2014.03.065
Homo sapiens	Nuclear receptor ROR-gamma	Ki	51.0	nM	10.1021/jm401901d
Homo sapiens	Nuclear receptor ROR-gamma	Ki	51.0	nM	10.1039/C3MD00005B
Homo sapiens	Parathyroid hormone receptor	Potency	112201.8	nM	None
Homo sapiens	PBMC	EC50	3000.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	PBMC	EC50	20000.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	PBMC	Imax	81.0	%	10.1016/j.bmcl.2013.10.054
Homo sapiens	Peregrin	Delta TM	-0.7765	C	None
Homo sapiens	Peregrin	Delta TM	-0.44	C	None
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.bmc.2009.04.012
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.bmcl.2009.11.062
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1021/jm100034x
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	nan	None	10.1016/j.bmc.2009.04.012
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	nan	None	10.1016/j.bmcl.2009.11.062
Homo sapiens	Peroxisome proliferator-activated receptor delta	Potency	44668.4	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2009.04.012
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2009.11.062
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	nan	None	10.1016/j.bmcl.2007.11.013
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Potency	35481.3	nM	None
Homo sapiens	Pregnane X receptor	Activity	93.0	%	10.1016/j.bmc.2006.12.026
Homo sapiens	Pregnane X receptor	Activity	nan	None	10.1021/acs.jmedchem.0c00012
Homo sapiens	Pregnane X receptor	EC50	8.0	nM	10.1016/j.bmcl.2017.12.006
Homo sapiens	Pregnane X receptor	EC50	12.59	nM	10.1016/j.bmc.2006.12.026
Homo sapiens	Pregnane X receptor	EC50	15.0	nM	10.1021/acs.jmedchem.0c00012
Homo sapiens	Pregnane X receptor	EC50	36.0	nM	10.1016/j.bmcl.2013.10.054
Homo sapiens	Pregnane X receptor	EC50	36.0	nM	10.1021/jm401901d
Homo sapiens	Pregnane X receptor	EC50	50.0	nM	10.1021/acsmedchemlett.8b00459
Homo sapiens	Pregnane X receptor	EC50	120.0	nM	10.1016/j.bmc.2018.07.038
Homo sapiens	Pregnane X receptor	EC50	270.0	nM	10.1016/j.bmcl.2016.02.031
Homo sapiens	Pregnane X receptor	EC50	nan	None	10.1021/acs.jmedchem.0c02201
Homo sapiens	Pregnane X receptor	FC	22.0	None	10.1016/j.bmcl.2013.10.054
Homo sapiens	Pregnane X receptor	IC50	26.0	nM	10.1021/acs.jmedchem.2c01640
Homo sapiens	Pregnane X receptor	IC50	36.0	nM	10.1021/acs.jmedchem.0c02201
Homo sapiens	Pregnane X receptor	IC50	39.81	nM	10.1016/j.bmc.2006.12.026
Homo sapiens	Pregnane X receptor	IC50	nan	None	10.1021/acs.jmedchem.0c02201
Homo sapiens	Pregnane X receptor	Inhibition	100.0	%	10.1021/acs.jmedchem.0c02201
Homo sapiens	Pregnane X receptor	Inhibition	100.0	%	10.1021/acs.jmedchem.2c01640
Homo sapiens	Pregnane X receptor	%max	84.0	%	10.1016/j.bmcl.2017.12.006
Homo sapiens	Rap guanine nucleotide exchange factor 3	Potency	8912.5	nM	None
Homo sapiens	Rap guanine nucleotide exchange factor 4	Potency	44668.4	nM	None
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha	Activity	nan	None	10.1016/j.bmcl.2015.07.047
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha	EC50	0.098	nM	10.1016/j.ejmech.2020.112240
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha	Efficacy	88.0	%	10.1016/j.ejmech.2020.112240
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha	Ki	31.0	nM	10.1016/j.bmcl.2014.11.029
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha	Ki	230.0	nM	10.1016/j.bmcl.2015.07.047
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta	Activity	nan	None	10.1016/j.bmcl.2015.07.047
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta	EC50	0.108	nM	10.1016/j.ejmech.2020.112240
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta	Efficacy	100.0	%	10.1016/j.ejmech.2020.112240
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta	Ki	26.0	nM	10.1016/j.bmcl.2014.11.029
Homo sapiens	Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta	Ki	220.0	nM	10.1016/j.bmcl.2015.07.047
Homo sapiens	Retinoid X receptor alpha	Potency	12589.3	nM	None
Homo sapiens	Serine/threonine-protein kinase Aurora-A	Delta TM	-0.68	C	None
Homo sapiens	Serine/threonine-protein kinase Aurora-A	Delta TM	0.1476	C	None
Homo sapiens	TAR DNA-binding protein 43	Potency	22387.2	nM	None
Homo sapiens	THP-1	Activity	0.93	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	1.0	None	10.1021/jm800612u
Homo sapiens	THP-1	Activity	1.05	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	1.17	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	1.26	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	1.78	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	2.59	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	4.09	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	4.2	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	4.56	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	5.9	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	8.16	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	15.05	None	10.1021/jm7011326
Homo sapiens	THP-1	Activity	100.0	%	10.1016/j.bmcl.2007.11.013
Homo sapiens	THP-1	Activity	nan	None	10.1021/acsmedchemlett.5b00170
Homo sapiens	THP-1	Activity	nan	None	10.1021/jm901797p
Homo sapiens	THP-1	EC50	3.0	nM	10.1016/j.bmcl.2009.11.062
Homo sapiens	THP-1	EC50	3.0	nM	10.1021/jm800799q
Homo sapiens	THP-1	EC50	33.0	nM	10.1016/j.bmcl.2007.03.076
Homo sapiens	THP-1	EC50	33.0	nM	10.1016/j.bmcl.2007.06.017
Homo sapiens	THP-1	EC50	35.0	nM	10.1016/j.bmcl.2009.11.099
Homo sapiens	THP-1	EC50	44.0	nM	10.1016/j.bmcl.2007.11.013
Homo sapiens	THP-1	EC50	44.0	nM	10.1016/j.bmcl.2009.11.062
Homo sapiens	THP-1	EC50	44.0	nM	10.1016/j.bmcl.2009.11.098
Homo sapiens	THP-1	EC50	44.0	nM	10.1021/jm100034x
Homo sapiens	THP-1	EC50	44.0	nM	10.1021/jm800799q
Homo sapiens	THP-1	Efficacy	100.0	%	10.1016/j.bmcl.2009.11.098
Homo sapiens	THP-1	Efficacy	100.0	%	10.1016/j.bmcl.2009.11.099
Homo sapiens	THP-1	Efficacy	100.0	%	10.1021/jm800799q
Homo sapiens	THP-1	IC50	100.0	nM	10.1021/jm800612u
Homo sapiens	THP-1	Ratio	1.6	None	10.1016/j.bmcl.2007.03.076
Homo sapiens	THP-1	Ratio	1.6	None	10.1016/j.bmcl.2007.06.017
Homo sapiens	THP-1	Ratio	6.7	None	10.1016/j.bmcl.2007.03.076
Homo sapiens	THP-1	Ratio	8.4	None	10.1016/j.bmcl.2007.03.076
Homo sapiens	THP-1	Ratio	8.4	None	10.1016/j.bmcl.2007.06.017
Homo sapiens	Thyroid hormone receptor beta-1	Potency	44.7	nM	None
Homo sapiens	Transcription intermediary factor 1-alpha	Delta TM	-1.201	C	None
Homo sapiens	Transcription intermediary factor 1-alpha	Delta TM	0.39	C	None
Homo sapiens	Tyrosine-protein kinase ABL	Delta TM	-0.7513	C	None
Homo sapiens	Tyrosine-protein kinase ABL	Delta TM	0.78	C	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	20596.2	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	22387.2	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	29092.9	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	35481.3	nM	None
Homo sapiens	U2OS	Control DMSO Fragmented Nuclei %	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Fragmented Nuclei %	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Fragmented Nuclei %	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Fragmented Nuclei %	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Fragmented Nuclei %	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Fragmented Nuclei %	17.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Fragmented Nuclei %	39.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	54.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	70.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	73.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	77.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	81.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	87.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	89.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Healthy Nuclei (%)	90.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Membrane Permeable-Phenotype Cells (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Membrane Permeable-Phenotype Cells (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Membrane Permeable-Phenotype Cells (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Membrane Permeable-Phenotype Cells (%)	9.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitochondria Different-Phenotype Cells (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitochondria Different-Phenotype Cells (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	32.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	39.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	42.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	48.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	50.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	52.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	60.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Mitotic Cells (%)	62.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Pyknosed Nuclei (%)	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Pyknosed Nuclei (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Pyknosed Nuclei (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Pyknosed Nuclei (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Pyknosed Nuclei (%)	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Pyknosed Nuclei (%)	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Pyknosed Nuclei (%)	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	33.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	43.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	54.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	92.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	149.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	255.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	361.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Total Cells	732.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	64.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	69.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	70.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	91.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	92.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Control DMSO Tubulin Phenotype Different Cells (%)	93.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Growth Rate	-0.29	None	10.6019/CHEMBL5058564
Homo sapiens	U2OS	Growth Rate	0.0	None	10.6019/CHEMBL4689842
Homo sapiens	U2OS	Growth Rate	0.14	None	10.6019/CHEMBL5058564
Homo sapiens	U2OS	Growth Rate	0.74	None	10.6019/CHEMBL5058564
Homo sapiens	U2OS	Growth Rate	0.76	None	10.6019/CHEMBL5058564
Homo sapiens	U2OS	Growth Rate	0.81	None	10.6019/CHEMBL5058564
Homo sapiens	U2OS	Growth Rate	0.83	None	10.6019/CHEMBL5058564
Homo sapiens	U2OS	Growth Rate	0.98	None	10.6019/CHEMBL5058564
Homo sapiens	U2OS	Growth Rate	1.0	None	10.6019/CHEMBL4689842
Homo sapiens	U2OS	Population Apoptotic (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	33.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	35.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	36.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	39.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	45.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	50.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	52.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	56.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	57.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	75.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	79.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Apoptotic (%)	100.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	15.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	20.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	24.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	27.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	35.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	36.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	40.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Fragmented Nuclei (%)	64.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	35.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	56.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	58.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	62.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	65.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	70.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	78.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	80.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	81.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	82.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	86.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	88.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Healthy Nuclei (%)	90.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Hoechst High Intensity Objects (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Hoechst High Intensity Objects (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Hoechst High Intensity Objects (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	16.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Membrane Permeable-Phenotype (%)	19.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitochondria Different-Phenotype (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitochondria Different-Phenotype (%)	1.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitochondria Different-Phenotype (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitochondria Different-Phenotype (%)	3.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitochondria Different-Phenotype (%)	5.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitochondria Different-Phenotype (%)	8.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitochondria Different-Phenotype (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	20.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	25.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	33.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	42.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	43.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	47.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	50.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	54.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	60.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	63.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	64.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Mitotic Cells (%)	66.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Normal (%)	96.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Normal (%)	97.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Normal (%)	100.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	2.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	4.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	6.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	7.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	9.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	10.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	11.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	12.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	13.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	14.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Pyknosed Nuclei (%)	16.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	0.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	34.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	40.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	41.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	47.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	52.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	58.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	59.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	72.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	81.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	82.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Population Tubulin-Different-Phenotype (%)	84.0	%	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	37.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	38.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	39.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	41.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	49.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	63.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	65.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	121.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	165.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	183.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	217.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	224.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	317.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	326.0	None	10.6019/CHEMBL5303300
Homo sapiens	U2OS	Total Cell Count	643.0	None	10.6019/CHEMBL5303300
Homo sapiens	U-87 MG	IC50	nan	None	10.1016/j.ejmech.2020.112240
Homo sapiens	Vitamin D receptor	Potency	35481.3	nM	None
Homo sapiens	Vitamin D receptor	Potency	50118.7	nM	None
Macaca fascicularis	Cynomolgus monkey	FC	6.0	None	10.1021/acsmedchemlett.6b00234
Macaca mulatta	Rhesus monkey	Activity	25.0	%	10.1021/acs.jmedchem.6b00176
Macaca mulatta	Rhesus monkey	Activity	nan	None	10.1021/acs.jmedchem.6b00176
Macaca mulatta	Rhesus monkey	FC	4.0	None	10.1021/acs.jmedchem.6b00176
Mus musculus	J774	Activity	100.0	%	10.1016/j.bmcl.2007.11.013
Mus musculus	J774	Activity	100.0	%	10.1016/j.bmcl.2010.03.031
Mus musculus	J774	EC50	35.0	nM	10.1016/j.bmcl.2007.11.013
Mus musculus	J774	EC50	35.0	nM	10.1016/j.bmcl.2010.03.031
Mus musculus	J774.A1	EC50	34.0	nM	10.1016/j.bmc.2009.04.012
Mus musculus	J774.A1	EC50	35.0	nM	10.1016/j.bmcl.2009.10.132
Mus musculus	J774.A1	Efficacy	100.0	%	10.1016/j.bmcl.2009.10.132
Mus musculus	Liver	Drug uptake	7900.0	ng/g	10.1016/j.bmcl.2009.01.109
Mus musculus	Mus musculus	Activity	20.0	%	10.1016/j.bmcl.2009.01.109
Mus musculus	Mus musculus	Activity	23.0	%	10.1016/j.bmcl.2009.01.109
Mus musculus	Mus musculus	Activity	40.0	%	10.1016/j.bmc.2016.05.048
Mus musculus	Mus musculus	Activity	47.0	%	10.1016/j.bmc.2016.05.048
Mus musculus	Mus musculus	Activity	55.0	%	10.1016/j.bmc.2016.05.048
Mus musculus	Mus musculus	Activity	96.0	%	10.1016/j.bmc.2016.05.048
Mus musculus	Mus musculus	Activity	270.0	%	10.1016/j.bmcl.2009.01.109
Mus musculus	Mus musculus	Activity	465.0	%	10.1016/j.bmc.2016.05.048
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmcl.2015.07.047
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2019.111647
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acs.jmedchem.6b00176
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm100034x
Mus musculus	Mus musculus	AUC	3421.0	ng.hr.mL-1	10.1016/j.bmcl.2005.12.015
Mus musculus	Mus musculus	Cp	255.0	ng/ml	10.1016/j.bmcl.2009.01.109
Mus musculus	Mus musculus	FC	1.0	None	10.1016/j.bmcl.2009.02.039
Mus musculus	Mus musculus	FC	1.5	None	10.1016/j.bmcl.2009.02.039
Mus musculus	Mus musculus	FC	2.5	None	10.1016/j.bmc.2016.05.048
Mus musculus	Mus musculus	FC	2.9	None	10.1016/j.bmc.2016.05.048
Mus musculus	Mus musculus	FC	4.5	None	10.1016/j.bmcl.2016.08.089
Mus musculus	Mus musculus	T1/2	3.0	hr	10.1016/j.bmcl.2005.12.015
Mus musculus	Nuclear receptor ROR-alpha	IC20	12.0	uM	10.1039/C3MD00005B
Mus musculus	Nuclear receptor ROR-gamma	IC20	1.0	uM	10.1039/C3MD00005B
Mus musculus	Nuclear receptor ROR-gamma	Potency	1995.3	nM	None
Mus musculus	Oxysterols receptor LXR-beta	EC50	27.0	nM	10.1016/j.bmc.2009.10.001
Mus musculus	Retinoid X receptor alpha	Activity	nan	None	10.1021/acs.jmedchem.0c01354
Rattus norvegicus	Liver microsomes	T1/2	0.5	hr	10.1016/j.bmcl.2009.10.132
Rattus norvegicus	Liver microsomes	T1/2	0.5	hr	10.1016/j.bmcl.2009.11.098
Rattus norvegicus	Liver microsomes	T1/2	0.5	hr	10.1016/j.bmcl.2010.03.031
Rattus norvegicus	Nuclear receptor subfamily 1 group I member 2	Potency	1122.0	nM	None
Rattus norvegicus	Oxysterols receptor LXR-beta	EC50	30.0	nM	10.1016/j.bmcl.2019.03.051
Rattus norvegicus	Oxysterols receptor LXR-beta	Efficacy	98.0	%	10.1016/j.bmcl.2019.03.051
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2016.08.089
Rattus norvegicus	Rattus norvegicus	AUC	5920.0	ng.hr.mL-1	10.1016/j.bmcl.2005.12.015
Rattus norvegicus	Rattus norvegicus	FC	5.0	None	10.1016/j.bmcl.2016.08.089
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	-3.18	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	14.15	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-2.79	%	10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-0.04	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	2.69	%	10.6019/CHEMBL4495565
None	ADMET	Activity	nan	None	10.1016/j.bmc.2022.116792
None	ADMET	Activity	nan	None	10.1016/j.ejmech.2019.111647
None	ADMET	Activity	nan	None	10.1021/jm3002394
None	ADMET	CL	3.0	mL.min-1.g-1	10.6019/CHEMBL3301361
None	ADMET	CL	5.37	uL.min-1.(10^6cells)-1	10.6019/CHEMBL3301361
None	ADMET	CL	14.13	uL.min-1.(10^6cells)-1	10.6019/CHEMBL3301361
None	ADMET	CLH	nan	None	10.1021/acs.jmedchem.1c01746
None	ADMET	Cp	200.0	nM	10.1021/acsmedchemlett.6b00234
None	ADMET	Cp	2796.0	nM	10.1016/j.bmcl.2016.08.089
None	ADMET	Cp	3768.0	nM	10.1016/j.bmcl.2016.08.089
None	ADMET	Drug uptake	5364.0	nM	10.1016/j.bmcl.2016.08.089
None	ADMET	Drug uptake	8048.0	nM	10.1016/j.bmcl.2016.08.089
None	ADMET	PPB	99.56	%	10.6019/CHEMBL3301361
None	ADMET	PPB	99.71	%	10.6019/CHEMBL3301361
None	ADMET	Stability	65.0	%	10.1021/jm800612u
None	ADMET	t1/2	nan	None	10.1021/acs.jmedchem.1c01746
None	ADMET	T1/2	0.5	hr	10.1016/j.bmcl.2009.11.098
None	ADMET	TI	10.0	None	10.1016/j.ejmech.2016.07.005
None	Molecular identity unknown	Inhibition	nan	%	10.1021/jm3002394
None	Molecular identity unknown	Potency	20.0	nM	None
None	NON-PROTEIN TARGET	Activity	73.3	%	10.1016/j.ejmech.2016.07.005
None	NON-PROTEIN TARGET	Activity	94.8	%	10.1016/j.ejmech.2016.07.005
None	NON-PROTEIN TARGET	Activity	140.0	%	10.1021/acsmedchemlett.6b00234
None	NON-PROTEIN TARGET	IC50	50000.0	nM	10.1016/j.ejmech.2016.07.005
None	No relevant target	LogD7.4	4.5	None	10.6019/CHEMBL3301361
None	No relevant target	LogP	5.38	None	10.1016/j.bmc.2018.07.038
None	No relevant target	LogP	5.38	None	10.1016/j.bmcl.2016.02.031
None	Peritoneal macrophage cell	Inhibition	nan	%	10.1021/jm3002394
None	Unchecked	AbsAC40_uM	6.8	uM	None
None	Unchecked	Activity	64.2	%	10.1016/j.ejmech.2016.07.005
None	Unchecked	Activity	380.0	%	10.1021/acsmedchemlett.9b00306
None	Unchecked	Activity	nan	None	10.1016/j.bmc.2008.02.078
None	Unchecked	Activity	nan	None	10.1016/j.bmc.2013.10.024
None	Unchecked	Activity	nan	None	10.1016/j.ejmech.2016.07.005
None	Unchecked	Activity	nan	None	10.1021/acs.jmedchem.7b00091
None	Unchecked	EC50	70.0	nM	10.1021/jm050532w
None	Unchecked	EC50	201.0	nM	10.1021/acs.jmedchem.0c01065
None	Unchecked	EC50	310.0	nM	10.1021/acsmedchemlett.6b00234
None	Unchecked	Efficacy	100.0	%	10.1021/acsmedchemlett.6b00234
None	Unchecked	IC50	50.0	nM	10.1021/acs.jmedchem.0c00262
None	Unchecked	IC50	100000.0	nM	10.1016/j.bmc.2008.02.078
None	Unchecked	Inhibition	52.7	%	10.1016/j.bmc.2022.116936
None	Unchecked	Potency	2238.7	nM	None
None	Unchecked	Potency	8912.5	nM	None
None	Unchecked	Potency	11220.2	nM	None
None	Unchecked	Potency	18356.4	nM	None
None	Unchecked	Potency	22387.2	nM	None
None	Unchecked	Potency	39810.7	nM	None
None	Unchecked	Potency	50118.7	nM	None
None	Unchecked	Ratio EC50	0.9	None	10.1016/j.ejmech.2020.112240
None	Unchecked	Ratio EC50	1.01	None	10.1016/j.bmc.2022.116792
None	Unchecked	Ratio EC50	10.0	None	10.1016/j.bmcl.2013.10.054
None	Unchecked	RE	1.0	None	10.1021/jm050532w