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2-(morpholin-4-yl)-8-phenylchromen-4-one

AlkaPlorer ID: AK272847

Synonym: None

IUPAC Name: 2-morpholin-4-yl-8-phenylchromen-4-one

Structure

SMILES: O=C1C=C(N2CCOCC2)OC2=C1C=CC=C2C1=CC=CC=C1

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InChI: InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2

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InChIKey: CZQHHVNHHHRRDU-UHFFFAOYSA-N

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Reference

PubChem CID: 3973

CAS: 154447-36-6

SuperNatural Ⅲ: SN0059927

NPASS: NPC462686

COCONUT: CNP0033193

Properties Information

Molecule Weight: 307.349

TPSA？: 42.68000000000001

MolLogP？: 3.296600000000001

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus PI3-kinase p110-alpha subunit IC50 630.0 nM 10.1016/j.bmc.2006.09.047
Bos taurus PI3-kinase p110-alpha subunit IC50 630.0 nM 10.1016/j.bmc.2007.05.070
Bos taurus PI3-kinase p110-alpha subunit IC50 6300.0 nM 10.1021/acs.jmedchem.2c01070
Bos taurus PI3-kinase p110-alpha subunit IC50 10000.0 nM 10.1042/0264-6021:3510095
Bos taurus PI3-kinase p110-alpha subunit Inhibition 13.0 % 10.1042/0264-6021:3510095
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Danio rerio Danio rerio Activity nan None 10.1039/C7MD00475C
Gallus gallus Tyrosine-protein kinase SRC Activity 106.0 % 10.1042/bj20070797
Hepacivirus hominis Hepatitis C virus FC 5.0 None 10.1021/acs.jmedchem.0c01467
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 89.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens 786-0 GI50 9682.78 nM None
Homo sapiens A2780 Activity nan None 10.1074/jbc.m703796200
Homo sapiens A-375 IC50 8400.0 nM 10.1016/j.bmc.2007.05.070
Homo sapiens A498 GI50 2477.42 nM None
Homo sapiens A549 Activity 3.24 % 10.1039/C5MD00603A
Homo sapiens A549 Activity 5.15 % 10.1039/C5MD00603A
Homo sapiens A549 Activity 9.24 % 10.1039/C5MD00603A
Homo sapiens A549 Activity 82.95 % 10.1039/C5MD00603A
Homo sapiens A549 Activity nan None 10.1021/acs.jnatprod.2c00457
Homo sapiens A549 GI50 4786.3 nM None
Homo sapiens A549 IC50 8400.0 nM 10.1016/j.bmc.2006.09.047
Homo sapiens A549 IC50 17700.0 nM 10.1039/C5MD00603A
Homo sapiens A549 IC50 82320.0 nM 10.1016/j.bmc.2015.01.052
Homo sapiens A549 IC50 82320.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens A549 IC50 82320.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens A549 IC50 89650.0 nM 10.1016/j.bmc.2012.03.026
Homo sapiens A549 IC50 89650.0 nM 10.1016/j.ejmech.2011.09.015
Homo sapiens A549 IC50 89650.0 nM 10.1039/C2MD00255H
Homo sapiens A549 Inhibition 84.27 % 10.1021/acs.jnatprod.2c00457
Homo sapiens A549 Inhibition nan % 10.1021/acs.jnatprod.2c00457
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN GI50 7447.32 nM None
Homo sapiens Activin receptor type-1B Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 39810.7 nM None
Homo sapiens ALK tyrosine kinase receptor Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change -0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Arachidonate 15-lipoxygenase Potency 39810.7 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 25118.9 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 14575.0 nM None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens BRD2/BRD3 IC50 12430.0 nM 10.1021/acs.jmedchem.6b00438
Homo sapiens Bromodomain-containing protein 2 IC50 10300.0 nM 10.1038/nrd.2016.266
Homo sapiens Bromodomain-containing protein 3 IC50 13700.0 nM 10.1038/nrd.2016.266
Homo sapiens Bromodomain-containing protein 4 IC50 12400.0 nM 10.1038/nrd.2016.266
Homo sapiens Bromodomain testis-specific protein IC50 12430.0 nM 10.1021/acs.jmedchem.6b00438
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Activity 104.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens BT-474 IC50 20700.0 nM 10.1021/jm301522m
Homo sapiens BT-549 GI50 5701.64 nM None
Homo sapiens CAKI-1 GI50 2393.32 nM None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens CaM kinase I alpha Activity 87.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase alpha Activity 71.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 71.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 97.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 nan None 10.1016/j.bmcl.2007.02.032
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Casein kinase I delta Activity 57.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase II Activity 23.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II IC50 6900.0 nM 10.1042/0264-6021:3510095
Homo sapiens Casein kinase II Inhibition 18.0 % 10.1042/0264-6021:3510095
Homo sapiens Casein kinase II Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM GI50 39084.09 nM None
Homo sapiens CDK3/cyclin E Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Cell division cycle 2-like protein kinase 6 Ki 100000.0 nM None
Homo sapiens Cell division protein kinase 8 Ki 3162.28 nM None
Homo sapiens Cellular tumor antigen p53 Potency 10000.0 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Chromobox protein homolog 1 Potency 26679.5 nM None
Homo sapiens c-Jun N-terminal kinase 1 Activity 92.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Inhibition 108.0 % 10.1042/0264-6021:3510095
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Activity 97.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Activity 86.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase, JNK Activity nan None 10.1016/j.bmcl.2012.05.013
Homo sapiens COLO 205 GI50 13489.63 nM None
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 81.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 131.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 nan None 10.1016/j.bmcl.2007.02.032
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 AC50 199.53 nM None
Homo sapiens Cytochrome P450 1A2 AC50 1584.89 nM None
Homo sapiens Cytochrome P450 1A2 IC50 1000.0 nM None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C19 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 2C9 AC50 39810.72 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2C9 Potency 39810.7 nM None
Homo sapiens Cytochrome P450 2D6 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2D6 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 AC50 5011.87 nM None
Homo sapiens Cytochrome P450 3A4 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 5011.9 nM None
Homo sapiens Cytochrome P450 3A4 Potency 10000.0 nM None
Homo sapiens Death-associated protein kinase 1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Thermal melting change 1.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens DNA-dependent protein kinase IC50 300.0 nM 10.1016/j.ejmech.2016.01.042
Homo sapiens DNA-dependent protein kinase IC50 1200.0 nM 10.1016/j.bmcl.2004.09.060
Homo sapiens DNA-dependent protein kinase IC50 1200.0 nM 10.1021/jm501026z
Homo sapiens DNA-dependent protein kinase IC50 1300.0 nM 10.1016/j.bmcl.2010.12.047
Homo sapiens DNA-dependent protein kinase IC50 1400.0 nM 10.1016/s0960-894x(01)00537-6
Homo sapiens DNA-dependent protein kinase IC50 1400.0 nM 10.1016/s0960-894x(03)00652-8
Homo sapiens DNA-dependent protein kinase IC50 1400.0 nM 10.1021/jm400915j
Homo sapiens DNA-dependent protein kinase IC50 1470.0 nM 10.1021/jm049526a
Homo sapiens DNA-dependent protein kinase IC50 1470.0 nM 10.1021/jm050444b
Homo sapiens DNA-dependent protein kinase IC50 1500.0 nM 10.1021/jm049526a
Homo sapiens DNA-dependent protein kinase IC50 1600.0 nM 10.1016/j.bmcl.2008.07.066
Homo sapiens DNA-dependent protein kinase IC50 1600.0 nM 10.1016/j.bmcl.2010.04.102
Homo sapiens DNA-dependent protein kinase Ki 6000.0 nM 10.1016/j.bmcl.2012.06.053
Homo sapiens DNA-dependent protein kinase Ki 6000.0 nM 10.1016/s0960-894x(03)00652-8
Homo sapiens DNA-dependent protein kinase Ki 6000.0 nM 10.1021/jm400915j
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens DU-145 GI50 12445.15 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change -0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 76.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 94.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 78.0 % 10.1042/bj20070797
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change 1.3 degrees C 10.1073/pnas.0708800104
Homo sapiens EKVX GI50 3491.4 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 39810.7 nM None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Ephrin type-A receptor 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Flap endonuclease 1 Potency 21192.3 nM None
Homo sapiens Focal adhesion kinase 1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Forkhead box protein O3 Activity nan None 10.1021/acs.jnatprod.1c01030
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Activity 37.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta IC50 8100.0 nM 10.1021/jm701437d
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 53.0 % 10.1042/0264-6021:3510095
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 1.1 degrees C 10.1073/pnas.0708800104
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens H4 Activity 11.09 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 14.79 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 24.99 % 10.1073/pnas.0709695104
Homo sapiens HCT-116 FC 3.8 None 10.1016/j.bmcl.2011.12.044
Homo sapiens HCT-116 FC 8.5 None 10.1016/j.bmcl.2011.12.044
Homo sapiens HCT-116 FC 8.6 None 10.1016/j.bmcl.2011.12.044
Homo sapiens HCT-116 GI50 12618.28 nM None
Homo sapiens HCT-116 IC50 5300.0 nM 10.1016/j.bmcl.2011.12.044
Homo sapiens HCT-116 IC50 5800.0 nM 10.1016/j.bmcl.2011.12.044
Homo sapiens HCT-116 IC50 6700.0 nM 10.1016/j.bmcl.2011.12.044
Homo sapiens HCT-116 IC50 51820.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens HCT-116 IC50 51820.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens HCT-116 IC50 56010.0 nM 10.1016/j.bmc.2012.03.026
Homo sapiens HCT-116 IC50 56010.0 nM 10.1016/j.ejmech.2011.09.015
Homo sapiens HCT-116 IC50 56010.0 nM 10.1039/C2MD00255H
Homo sapiens HCT-116 Inhibition nan % 10.1016/j.bmcl.2011.12.044
Homo sapiens HCT-116 TGI 35.2 % 10.1016/j.ejmech.2019.111630
Homo sapiens HCT-15 GI50 7906.79 nM None
Homo sapiens HEK-293T CC50 20000.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens HeLa IC50 20500.0 nM 10.1039/C5MD00603A
Homo sapiens Hepatocyte growth factor receptor Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histone deacetylase 6 Inhibition 1.23 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 5.65 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 31622.8 nM None
Homo sapiens HL-60 GI50 14689.26 nM None
Homo sapiens HL-60 IC50 9940.0 nM 10.1016/j.bmc.2012.03.026
Homo sapiens HL-60 IC50 9940.0 nM 10.1016/j.ejmech.2011.09.015
Homo sapiens HL-60 IC50 9940.0 nM 10.1039/C2MD00255H
Homo sapiens HL-60 IC50 18430.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens HL-60 IC50 18430.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 38.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 77.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens HOP-62 GI50 4591.98 nM None
Homo sapiens HOP-92 GI50 9036.49 nM None
Homo sapiens Hs-578T GI50 1901.08 nM None
Homo sapiens HT-29 GI50 6251.73 nM None
Homo sapiens Huh-7 IC50 67180.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens Huh-7 IC50 67180.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens HUVEC Inhibition nan % 10.1021/np200631v
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 7943.3 nM None
Homo sapiens Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha Activity nan None 10.1016/j.bmcl.2008.04.078
Homo sapiens IGROV-1 Activity 3.0 % 10.1016/j.bmc.2010.12.006
Homo sapiens IGROV-1 Activity 7.0 % 10.1016/j.bmc.2010.12.006
Homo sapiens IGROV-1 Activity 15.0 % 10.1016/j.bmc.2010.12.006
Homo sapiens IGROV-1 Activity 21.0 % 10.1016/j.bmc.2010.12.006
Homo sapiens IGROV-1 Activity 72.0 % 10.1016/j.bmc.2010.12.006
Homo sapiens IGROV-1 Activity 82.0 % 10.1016/j.bmc.2010.12.006
Homo sapiens IGROV-1 GI50 2494.59 nM None
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 68.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Insulin-like growth factor I receptor Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 133.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Jurkat IC50 22000.0 nM 10.1016/j.ejmech.2016.02.047
Homo sapiens K562 GI50 14190.58 nM None
Homo sapiens K562 IC50 38000.0 nM 10.1016/j.ejmech.2016.02.047
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KB IC50 44760.0 nM 10.1016/j.bmc.2012.03.026
Homo sapiens KB IC50 44760.0 nM 10.1016/j.ejmech.2011.09.015
Homo sapiens KM12 GI50 12078.14 nM None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens LIM domain kinase 1 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens LNCaP Activity nan None 10.1016/j.bmcl.2012.07.031
Homo sapiens LOX IMVI GI50 3715.35 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 39810.7 nM None
Homo sapiens M14 GI50 11142.95 nM None
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Malme-3M GI50 286.42 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Activity 103.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 74.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Activity 119.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Activity 83.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Inhibition 68.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Activity 85.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK1 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Thermal melting change -0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 Activity 88.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Inhibition 114.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 77.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 101.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Inhibition 98.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens MAP kinase p38 alpha Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Activity 100.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Inhibition 98.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 beta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Thermal melting change -0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase p38 delta Activity 102.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Inhibition 94.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 delta Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Activity 89.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Inhibition 97.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 gamma Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Activity 86.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 Activity 22.0 % 10.1016/j.bmc.2008.07.076
Homo sapiens MCF7 Activity 97.0 % 10.1016/j.bmc.2008.07.076
Homo sapiens MCF7 GI50 2630.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MCF7 GI50 3080.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MCF7 GI50 3090.3 nM None
Homo sapiens MCF7 GI50 3160.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MCF7 IC50 29100.0 nM 10.1039/C5MD00603A
Homo sapiens MDA-MB-231 Activity 49.0 % 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-231 Activity 65.0 % 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-231 GI50 3133.29 nM None
Homo sapiens MDA-MB-231 GI50 3320.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-231 GI50 4350.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-231 GI50 6710.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-231 IC50 380.0 nM 10.1016/j.bmcl.2017.02.051
Homo sapiens MDA-MB-231 IC50 380.0 nM 10.1021/acs.jnatprod.6b00150
Homo sapiens MDA-MB-231 IC50 380.0 nM 10.1021/np300207c
Homo sapiens MDA-MB-231 IC50 9700.0 nM 10.1039/C5MD00603A
Homo sapiens MDA-MB-231 RatioGI50 5.87 None 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-231 RatioGI50 8.85 None 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-435 GI50 7798.3 nM None
Homo sapiens MDA-MB-468 Activity 46.0 % 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-468 Activity 70.0 % 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-468 GI50 4760.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-468 GI50 8200.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-MB-468 GI50 10400.0 nM 10.1016/j.bmc.2008.07.076
Homo sapiens MDA-N GI50 11803.21 nM None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MG-63 IC50 55200.0 nM 10.1021/acs.jmedchem.6b01720
Homo sapiens MGC-803 Activity 22.4 % 10.1016/j.ejmech.2013.06.014
Homo sapiens MGC-803 Activity 27.1 % 10.1016/j.ejmech.2013.06.014
Homo sapiens MGC-803 Activity 50.5 % 10.1016/j.ejmech.2013.06.014
Homo sapiens Misshapen-like kinase 1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 15 Activity 70.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens MOLT-4 GI50 11376.27 nM None
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens M-phase phosphoprotein 8 Potency 37685.8 nM None
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Activity 88.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 134.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens NCI/ADR-RES GI50 4764.31 nM None
Homo sapiens NCI-H1299 Activity nan None 10.1016/j.bmcl.2012.05.013
Homo sapiens NCI-H226 GI50 3926.45 nM None
Homo sapiens NCI-H23 GI50 3758.37 nM None
Homo sapiens NCI-H322M GI50 12705.74 nM None
Homo sapiens NCI-H460 GI50 11402.5 nM None
Homo sapiens NCI-H522 GI50 2213.09 nM None
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Neutrophil IC50 400.0 nM 10.1021/acs.jnatprod.7b00039
Homo sapiens Neutrophil IC50 1250.0 nM 10.1021/acs.jnatprod.7b00476
Homo sapiens Neutrophil IC50 1500.0 nM 10.1021/acs.jnatprod.7b00039
Homo sapiens Neutrophil IC50 1800.0 nM 10.1021/acs.jnatprod.6b01096
Homo sapiens Neutrophil IC50 2100.0 nM 10.1021/acs.jnatprod.7b00938
Homo sapiens Neutrophil IC50 3300.0 nM 10.1021/acs.jnatprod.6b01096
Homo sapiens Neutrophil IC50 3440.0 nM 10.1021/acs.jnatprod.7b00476
Homo sapiens Neutrophil IC50 5100.0 nM 10.1021/acs.jnatprod.7b00938
Homo sapiens Neutrophil Inhibition 71.5 % 10.1021/acs.jnatprod.7b00476
Homo sapiens Neutrophil Inhibition 96.5 % 10.1021/acs.jnatprod.7b00476
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 9200.0 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 7079.5 nM None
Homo sapiens OVCAR-3 GI50 7161.43 nM None
Homo sapiens OVCAR-3 IC50 9190.0 nM 10.1021/acs.jnatprod.1c01030
Homo sapiens OVCAR-4 GI50 2703.96 nM None
Homo sapiens OVCAR-5 GI50 12078.14 nM None
Homo sapiens OVCAR-8 GI50 4581.42 nM None
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens PBMC IC50 50000.0 nM 10.1016/j.ejmech.2016.02.047
Homo sapiens PC-3 Activity nan None 10.1021/jm300929v
Homo sapiens PC-3 FC 0.33 None 10.1038/nchembio790
Homo sapiens PC-3 GI50 2338.84 nM None
Homo sapiens PC-3 IC50 12100.0 nM 10.1021/jm301522m
Homo sapiens PC-3 IC50 61350.0 nM 10.1016/j.bmc.2012.03.026
Homo sapiens PC-3 IC50 61350.0 nM 10.1016/j.ejmech.2011.09.015
Homo sapiens PC-3 IC50 61350.0 nM 10.1039/C2MD00255H
Homo sapiens PDZ-binding kinase Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide IC50 2100.0 nM 10.1016/j.bmc.2006.09.047
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide IC50 2100.0 nM 10.1016/j.bmc.2007.05.070
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide IC50 2100.0 nM 10.1016/j.bmcl.2007.02.032
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide IC50 10400.0 nM 10.1021/ml500354e
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha IC50 27000.0 nM 10.1021/ml500354e
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma IC50 nan None 10.1021/ml500354e
Homo sapiens Phosphodiesterase 2A Basal inhibition 54.0 % 10.1016/j.bmcl.2004.03.043
Homo sapiens Phosphodiesterase 2A IC50 40000.0 nM 10.1016/j.bmcl.2004.03.043
Homo sapiens Phosphodiesterase 3 IC50 100000.0 nM 10.1016/j.bmcl.2004.03.043
Homo sapiens Phosphodiesterase 3A Inhibition 35.0 % 10.1016/j.bmcl.2005.10.092
Homo sapiens Phosphodiesterase 5A IC50 9614.0 nM None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens PI3-kinase p110-alpha subunit Activity nan None 10.1016/j.bmcl.2008.04.078
Homo sapiens PI3-kinase p110-alpha subunit Activity nan None 10.1074/jbc.m704741200
Homo sapiens PI3-kinase p110-alpha subunit FC 0.01 None 10.1016/j.bmc.2012.09.059
Homo sapiens PI3-kinase p110-alpha subunit FC 0.41 None 10.1016/j.bmc.2012.09.059
Homo sapiens PI3-kinase p110-alpha subunit IC50 200.0 nM 10.1016/j.bmcl.2009.02.115
Homo sapiens PI3-kinase p110-alpha subunit IC50 300.0 nM 10.1021/jm400915j
Homo sapiens PI3-kinase p110-alpha subunit IC50 356.0 nM 10.1021/jm301522m
Homo sapiens PI3-kinase p110-alpha subunit IC50 480.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens PI3-kinase p110-alpha subunit IC50 480.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens PI3-kinase p110-alpha subunit IC50 481.0 nM 10.1016/j.bmc.2015.01.052
Homo sapiens PI3-kinase p110-alpha subunit IC50 500.0 nM 10.1016/j.bmcl.2010.12.047
Homo sapiens PI3-kinase p110-alpha subunit IC50 500.0 nM 10.1021/acs.jmedchem.0c00766
Homo sapiens PI3-kinase p110-alpha subunit IC50 500.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens PI3-kinase p110-alpha subunit IC50 500.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens PI3-kinase p110-alpha subunit IC50 550.0 nM 10.1021/jm100531u
Homo sapiens PI3-kinase p110-alpha subunit IC50 550.0 nM 10.1021/jm501026z
Homo sapiens PI3-kinase p110-alpha subunit IC50 550.0 nM 10.1039/C2MD20044A
Homo sapiens PI3-kinase p110-alpha subunit IC50 600.0 nM 10.1021/ml500354e
Homo sapiens PI3-kinase p110-alpha subunit IC50 630.0 nM 10.1016/j.bmc.2012.03.026
Homo sapiens PI3-kinase p110-alpha subunit IC50 630.0 nM 10.1016/j.bmcl.2007.02.032
Homo sapiens PI3-kinase p110-alpha subunit IC50 720.0 nM 10.1021/jm0601598
Homo sapiens PI3-kinase p110-alpha subunit IC50 730.0 nM 10.1021/jm300847w
Homo sapiens PI3-kinase p110-alpha subunit IC50 2300.0 nM 10.1016/j.bmcl.2004.09.060
Homo sapiens PI3-kinase p110-alpha subunit IC50 2300.0 nM 10.1021/jm049526a
Homo sapiens PI3-kinase p110-alpha subunit IC50 2370.0 nM 10.1038/nrd.2016.266
Homo sapiens PI3-kinase p110-alpha subunit IC50 4000.0 nM 10.1016/j.ejmech.2016.01.042
Homo sapiens PI3-kinase p110-alpha subunit IC50 6180.0 nM 10.1016/j.bmc.2020.115976
Homo sapiens PI3-kinase p110-alpha subunit IC50 62800.0 nM 10.1021/acs.jmedchem.1c01674
Homo sapiens PI3-kinase p110-alpha subunit INH 8.9 nM 10.1021/acs.jmedchem.8b01492
Homo sapiens PI3-kinase p110-alpha subunit Inhibition nan % 10.1016/j.bmcl.2011.12.044
Homo sapiens PI3-kinase p110-alpha subunit Ki 6000.0 nM 10.1021/jm049526a
Homo sapiens PI3-kinase p110-alpha subunit Ratio IC50 nan None 10.1016/j.bmc.2015.01.052
Homo sapiens PI3-kinase p110-beta subunit IC50 270.0 nM 10.1021/jm400915j
Homo sapiens PI3-kinase p110-beta subunit IC50 306.0 nM 10.1021/jm0601598
Homo sapiens PI3-kinase p110-beta subunit IC50 310.0 nM 10.1021/jm300847w
Homo sapiens PI3-kinase p110-beta subunit IC50 340.0 nM 10.1016/j.bmc.2006.09.047
Homo sapiens PI3-kinase p110-beta subunit IC50 340.0 nM 10.1016/j.bmc.2007.05.070
Homo sapiens PI3-kinase p110-beta subunit IC50 340.0 nM 10.1016/j.bmcl.2007.02.032
Homo sapiens PI3-kinase p110-beta subunit IC50 420.0 nM 10.1038/nrd.2016.266
Homo sapiens PI3-kinase p110-beta subunit IC50 736.0 nM 10.1021/jm301522m
Homo sapiens PI3-kinase p110-beta subunit IC50 900.0 nM 10.1016/j.bmcl.2009.08.087
Homo sapiens PI3-kinase p110-beta subunit IC50 900.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens PI3-kinase p110-beta subunit IC50 970.0 nM 10.1016/j.bmc.2012.03.064
Homo sapiens PI3-kinase p110-beta subunit IC50 970.0 nM 10.1021/acs.jmedchem.0c00766
Homo sapiens PI3-kinase p110-beta subunit IC50 970.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens PI3-kinase p110-beta subunit IC50 980.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens PI3-kinase p110-beta subunit IC50 980.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens PI3-kinase p110-beta subunit IC50 983.0 nM 10.1016/j.bmc.2015.01.052
Homo sapiens PI3-kinase p110-beta subunit IC50 3000.0 nM 10.1016/j.ejmech.2016.01.042
Homo sapiens PI3-kinase p110-beta subunit IC50 13100.0 nM 10.1021/acs.jmedchem.1c01674
Homo sapiens PI3-kinase p110-beta subunit IC50 16000.0 nM 10.1021/jm501026z
Homo sapiens PI3-kinase p110-beta subunit Imax 25.0 uM 10.1016/j.ejmech.2016.06.010
Homo sapiens PI3-kinase p110-beta subunit INH 17.0 nM 10.1021/acs.jmedchem.8b01492
Homo sapiens PI3-kinase p110-beta subunit Inhibition 40.0 % 10.1016/j.bmcl.2009.08.087
Homo sapiens PI3-kinase p110-delta/p85-alpha INH 16.0 nM 10.1021/acs.jmedchem.8b01492
Homo sapiens PI3-kinase p110-delta subunit IC50 220.0 nM 10.1021/jm400915j
Homo sapiens PI3-kinase p110-delta subunit IC50 500.0 nM 10.1016/j.bmcl.2009.08.087
Homo sapiens PI3-kinase p110-delta subunit IC50 570.0 nM 10.1016/j.bmc.2012.03.064
Homo sapiens PI3-kinase p110-delta subunit IC50 570.0 nM 10.1021/acs.jmedchem.0c00766
Homo sapiens PI3-kinase p110-delta subunit IC50 570.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens PI3-kinase p110-delta subunit IC50 570.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens PI3-kinase p110-delta subunit IC50 950.0 nM 10.1016/j.ejmech.2016.01.042
Homo sapiens PI3-kinase p110-delta subunit IC50 1050.0 nM 10.1021/jm300847w
Homo sapiens PI3-kinase p110-delta subunit IC50 1330.0 nM 10.1021/jm0601598
Homo sapiens PI3-kinase p110-delta subunit IC50 1360.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens PI3-kinase p110-delta subunit IC50 1360.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens PI3-kinase p110-delta subunit IC50 1362.0 nM 10.1016/j.bmc.2015.01.052
Homo sapiens PI3-kinase p110-delta subunit IC50 1530.0 nM 10.1038/nrd.2016.266
Homo sapiens PI3-kinase p110-delta subunit IC50 1600.0 nM 10.1021/jm501026z
Homo sapiens PI3-kinase p110-delta subunit IC50 3223.0 nM 10.1021/jm301522m
Homo sapiens PI3-kinase p110-delta subunit IC50 14900.0 nM 10.1021/acs.jmedchem.1c01674
Homo sapiens PI3-kinase p110-delta subunit Inhibition 40.0 % 10.1016/j.bmcl.2009.08.087
Homo sapiens PI3-kinase p110-gamma subunit IC50 940.0 nM 10.1016/j.bmc.2019.04.021
Homo sapiens PI3-kinase p110-gamma subunit IC50 947.0 nM 10.1016/j.bmc.2015.01.052
Homo sapiens PI3-kinase p110-gamma subunit IC50 950.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens PI3-kinase p110-gamma subunit IC50 1200.0 nM 10.1016/j.bmcl.2009.02.115
Homo sapiens PI3-kinase p110-gamma subunit IC50 1500.0 nM 10.1016/j.ejmech.2016.01.042
Homo sapiens PI3-kinase p110-gamma subunit IC50 1600.0 nM 10.1016/j.bmc.2006.09.047
Homo sapiens PI3-kinase p110-gamma subunit IC50 1600.0 nM 10.1016/j.bmc.2007.05.070
Homo sapiens PI3-kinase p110-gamma subunit IC50 1600.0 nM 10.1016/j.bmcl.2007.02.032
Homo sapiens PI3-kinase p110-gamma subunit IC50 1720.0 nM 10.1016/j.bmcl.2006.10.080
Homo sapiens PI3-kinase p110-gamma subunit IC50 1775.0 nM 10.1021/jm301522m
Homo sapiens PI3-kinase p110-gamma subunit IC50 3020.0 nM 10.1021/jm400915j
Homo sapiens PI3-kinase p110-gamma subunit IC50 6600.0 nM 10.1021/jm300847w
Homo sapiens PI3-kinase p110-gamma subunit IC50 7200.0 nM 10.1016/j.ejmech.2015.12.020
Homo sapiens PI3-kinase p110-gamma subunit IC50 7260.0 nM 10.1007/s00044-013-0561-0
Homo sapiens PI3-kinase p110-gamma subunit IC50 7260.0 nM 10.1016/j.ejmech.2014.07.056
Homo sapiens PI3-kinase p110-gamma subunit IC50 7260.0 nM 10.1021/jm0601598
Homo sapiens PI3-kinase p110-gamma subunit IC50 12000.0 nM 10.1021/jm501026z
Homo sapiens PI3-kinase p110-gamma subunit IC50 nan None 10.1021/jm100531u
Homo sapiens PI3-kinase p110-gamma subunit INH 53.0 nM 10.1021/acs.jmedchem.8b01492
Homo sapiens PI3-kinase p85-alpha subunit IC50 1400.0 nM 10.1073/pnas.0708800104
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Proteinase-activated receptor 1 Imax 25.0 uM 10.1016/j.ejmech.2016.06.010
Homo sapiens Protein kinase C alpha Activity 77.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha IC50 nan None 10.1016/j.bmcl.2007.02.032
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Inhibition 91.0 % 10.1042/0264-6021:3510095
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein kinase C alpha Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Activity 106.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Activity 114.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Activity 75.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 127.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Pyruvate dehydrogenase kinase isoform 1 Inhibition 76.0 % 10.1042/0264-6021:3510095
Homo sapiens Pyruvate kinase isozymes M1/M2 Inhibition nan % 10.1021/acs.jmedchem.1c00981
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Regulator of G-protein signaling 4 Potency 18887.6 nM None
Homo sapiens Rho-associated protein kinase 1 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Inhibition 81.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 138.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 83.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 129.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens RPMI-8226 GI50 2958.01 nM None
Homo sapiens RXF 393 GI50 2766.94 nM None
Homo sapiens Serine-protein kinase ATM IC50 10000.0 nM 10.1021/jm400915j
Homo sapiens Serine-protein kinase ATM IC50 100000.0 nM 10.1016/j.bmcl.2004.09.060
Homo sapiens Serine-protein kinase ATM IC50 100000.0 nM 10.1021/jm049526a
Homo sapiens Serine-protein kinase ATR IC50 10000.0 nM 10.1021/jm400915j
Homo sapiens Serine-protein kinase ATR IC50 100000.0 nM 10.1016/j.bmcl.2004.09.060
Homo sapiens Serine-protein kinase ATR IC50 100000.0 nM 10.1021/jm049526a
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase AKT Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Activity nan None 10.1038/nchembio800
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 15.0 % 10.1021/acs.jnatprod.2c00457
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 60.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase AKT Inhibition nan % 10.1016/j.bmcl.2017.09.024
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 70.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 84.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 90.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 79.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST2 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change -0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase mTOR Activity nan None 10.1074/jbc.m704741200
Homo sapiens Serine/threonine-protein kinase mTOR IC50 1060.0 nM 10.1021/jm301522m
Homo sapiens Serine/threonine-protein kinase mTOR IC50 2500.0 nM 10.1016/j.bmcl.2004.09.060
Homo sapiens Serine/threonine-protein kinase mTOR IC50 2500.0 nM 10.1021/jm049526a
Homo sapiens Serine/threonine-protein kinase mTOR IC50 2800.0 nM 10.1021/jm400915j
Homo sapiens Serine/threonine-protein kinase mTOR IC50 3018.0 nM 10.1016/j.bmc.2011.01.067
Homo sapiens Serine/threonine-protein kinase mTOR IC50 3900.0 nM 10.1021/ml500354e
Homo sapiens Serine/threonine-protein kinase mTOR IC50 5000.0 nM 10.1074/jbc.m704741200
Homo sapiens Serine/threonine-protein kinase mTOR IC50 6796.0 nM 10.1016/j.bmc.2011.09.042
Homo sapiens Serine/threonine-protein kinase mTOR IC50 9900.0 nM 10.1016/j.ejmech.2015.08.031
Homo sapiens Serine/threonine-protein kinase mTOR IC50 10000.0 nM 10.1016/j.ejmech.2019.111630
Homo sapiens Serine/threonine-protein kinase mTOR Inhibition 45.0 % 10.1016/j.bmcl.2008.04.078
Homo sapiens Serine/threonine-protein kinase mTOR Potency 414.0 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 3689.8 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 4645.1 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 9268.3 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change 1.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 103.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 67.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 100.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change -0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 8.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 IC50 820.0 nM 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 IC50 4000.0 nM 10.1021/acsmedchemlett.1c00412
Homo sapiens Serine/threonine-protein kinase PIM1 IC50 4000.0 nM 10.1021/jm800937p
Homo sapiens Serine/threonine-protein kinase PIM1 IC50 4000.0 nM 10.1021/jm801242y
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change 4.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 65.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 1.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 13.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 IC50 1400.0 nM 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change 2.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 26.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 IC50 2000.0 nM 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 IC50 2100.0 nM 10.1074/jbc.m609603200
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change 4.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 IC50 3000.0 nM 10.1074/jbc.m609603200
Homo sapiens Serine/threonine-protein kinase PLK3 IC50 88000.0 nM 10.1074/jbc.m609603200
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 72.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 101.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 2796.0 nM None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 799.0 nM None
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 36707.0 nM None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 23359.0 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 1002.0 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 525.0 nM None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None 10.1021/jm2011657
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SF-268 GI50 2280.34 nM None
Homo sapiens SF-295 GI50 6531.31 nM None
Homo sapiens SF-539 GI50 7979.95 nM None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens SK-MEL-2 GI50 9931.16 nM None
Homo sapiens SK-MEL-28 GI50 16943.38 nM None
Homo sapiens SK-OV-3 GI50 14157.94 nM None
Homo sapiens SK-OV-3 Inhibition nan % 10.1016/j.bmcl.2017.09.024
Homo sapiens SN12C GI50 5357.97 nM None
Homo sapiens SNB-19 GI50 14621.77 nM None
Homo sapiens SNB-75 GI50 1111.73 nM None
Homo sapiens SR GI50 3357.38 nM None
Homo sapiens Stem cell growth factor receptor Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Survival motor neuron protein Potency 5623.4 nM None
Homo sapiens Survival motor neuron protein Potency 14125.4 nM None
Homo sapiens SW480 Activity nan None 10.1074/jbc.m610350200
Homo sapiens SW-620 GI50 21727.01 nM None
Homo sapiens T47D GI50 2488.86 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens THP-1 IC50 1010.0 nM 10.1021/jm0601598
Homo sapiens THP-1 IC50 1650.0 nM 10.1021/jm0601598
Homo sapiens THP-1 IC50 37000.0 nM 10.1021/jm0601598
Homo sapiens Thrombopoietin Potency 10000.0 nM None
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid stimulating hormone receptor Potency 6309.6 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 39810.7 nM None
Homo sapiens TK-10 GI50 23659.2 nM None
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Activity 104.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Inhibition 85.0 % 10.1042/0264-6021:3510095
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 3548.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5623.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 7307.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8199.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 13335.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23715.0 nM None
Homo sapiens U-251 GI50 19453.6 nM None
Homo sapiens U2OS IC50 62960.0 nM 10.1021/acs.jmedchem.6b01720
Homo sapiens UACC-257 GI50 14521.12 nM None
Homo sapiens UACC-62 GI50 3793.15 nM None
Homo sapiens UO-31 GI50 15848.93 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 nan None 10.1016/j.bmcl.2007.02.032
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Mammarenavirus juninense Junin virus FC 5.0 None 10.1021/acs.jmedchem.0c01467
Mus musculus J774 IC50 3700.0 nM 10.1021/acs.jnatprod.7b00384
Mus musculus J774 IC50 5100.0 nM 10.1021/acs.jnatprod.7b00384
Mus musculus J774 IC50 8900.0 nM 10.1021/acs.jnatprod.7b00384
Mus musculus Mus musculus Activity nan None 10.1021/acs.jnatprod.7b00384
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus PI3-kinase p110-alpha subunit IC50 500.0 nM 10.1016/j.bmc.2012.03.064
Mus musculus PI3-kinase p110-alpha subunit IC50 500.0 nM 10.1016/j.bmcl.2009.08.087
Mus musculus PI3-kinase p110-alpha subunit Inhibition 40.0 % 10.1016/j.bmcl.2009.08.087
Mus musculus RAW264.7 IC50 10000.0 nM 10.1021/jm0601598
Mus musculus Tyrosine-protein kinase LCK Activity 97.0 % 10.1042/bj20070797
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus L-type calcium channel alpha 1C/beta 2A IC50 12000.0 nM None
Plasmodium falciparum Plasmodium falciparum IC50 3000.0 nM 10.1021/acs.jmedchem.8b00329
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus RBL-2H3 Activity nan None 10.1016/j.bmc.2008.02.054
Rattus norvegicus Rho-associated protein kinase 2 Inhibition 104.0 % 10.1042/0264-6021:3510095
Rattus norvegicus Serine/threonine-protein kinase mTOR IC50 2500.0 nM 10.1021/jm501026z
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 25118.9 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 39810.7 nM None
Rattus norvegicus Tyrosine-protein kinase SYK Activity nan None 10.1016/j.bmc.2008.02.054
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 8.571 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -5.64 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.99 % 10.6019/CHEMBL4495565
Trypanosoma brucei 6-phospho-1-fructokinase Potency 12.0 nM None
Trypanosoma cruzi Cruzipain Potency 28183.8 nM None
Zaire ebolavirus Zaire ebolavirus EC50 1800.0 nM 10.1021/acs.jmedchem.0c01467
None ADMET Activity 75.0 % 10.1016/j.bmc.2008.07.076
None ADMET Activity 82.0 % 10.1016/j.bmc.2008.07.076
None ADMET Activity nan None 10.1021/jm300929v
None ADMET GI50 29370.0 nM 10.1016/j.bmc.2008.07.076
None ADMET GI50 32370.0 nM 10.1016/j.bmc.2008.07.076
None ADMET GI50 39370.0 nM 10.1016/j.bmc.2008.07.076
None Mast cell Activity nan None 10.1021/jm0601598
None Molecular identity unknown Activity nan None 10.1016/j.bmcl.2012.05.013
None Molecular identity unknown Inhibition nan % 10.1038/nchembio800
None Neutrophil IC50 0.4 ug.mL-1 10.1016/j.bmcl.2014.06.039
None Neutrophil IC50 0.92 ug.mL-1 10.1016/j.bmcl.2014.06.039
None Neutrophil IC50 1720.0 nM 10.1016/j.bmcl.2006.10.080
None Neutrophil Inhibition 73.0 % 10.1021/acs.jnatprod.6b00625
None Neutrophil Inhibition 99.0 % 10.1021/acs.jnatprod.6b00625
None NON-PROTEIN TARGET IC50 0.6 ug.mL-1 10.1016/j.bmcl.2014.11.002
None NON-PROTEIN TARGET IC50 1.18 ug.mL-1 10.1021/np100871g
None NON-PROTEIN TARGET IC50 1.2 ug.mL-1 10.1016/j.bmcl.2014.11.002
None NON-PROTEIN TARGET IC50 1.99 ug.mL-1 10.1021/np100871g
None NON-PROTEIN TARGET IC50 380.0 nM 10.1016/j.ejmech.2016.08.058
None NON-PROTEIN TARGET IC50 400.0 nM 10.1021/acs.jnatprod.5b00449
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/np500088u
None NON-PROTEIN TARGET IC50 1090.0 nM 10.1021/np100923z
None NON-PROTEIN TARGET IC50 1120.0 nM 10.1016/j.bmc.2011.01.034
None NON-PROTEIN TARGET IC50 1120.0 nM 10.1021/np300699f
None NON-PROTEIN TARGET IC50 1500.0 nM 10.1021/acs.jnatprod.5b00449
None NON-PROTEIN TARGET IC50 1500.0 nM 10.1021/np500088u
None NON-PROTEIN TARGET IC50 1920.0 nM 10.1016/j.bmc.2011.01.034
None NON-PROTEIN TARGET IC50 1920.0 nM 10.1021/np300699f
None NON-PROTEIN TARGET IC50 1980.0 nM 10.1021/np100923z
None NON-PROTEIN TARGET IC50 3650.0 nM 10.1016/j.bmcl.2016.05.060
None NON-PROTEIN TARGET IC50 3840.0 nM 10.1016/j.bmcl.2011.06.036
None NON-PROTEIN TARGET IC50 5150.0 nM 10.1016/j.bmcl.2016.05.060
None NON-PROTEIN TARGET IC50 6480.0 nM 10.1016/j.bmcl.2011.06.036
None NON-PROTEIN TARGET IC50 11100.0 nM 10.1021/jm301522m
None NON-PROTEIN TARGET IC50 14000.0 nM 10.1016/j.ejmech.2016.02.047
None NON-PROTEIN TARGET IC50 18100.0 nM 10.1021/jm301522m
None NON-PROTEIN TARGET IC50 18430.0 nM 10.1016/j.bmc.2015.01.052
None NON-PROTEIN TARGET IC50 46000.0 nM 10.1016/j.ejmech.2016.02.047
None NON-PROTEIN TARGET IC50 51820.0 nM 10.1016/j.bmc.2015.01.052
None NON-PROTEIN TARGET IC50 67180.0 nM 10.1016/j.bmc.2015.01.052
None NON-PROTEIN TARGET Potency 1.2 nM None
None NON-PROTEIN TARGET Potency 6.7 nM None
None NON-PROTEIN TARGET Potency 1058.4 nM None
None NON-PROTEIN TARGET Potency 2658.6 nM None
None NON-PROTEIN TARGET Potency 13324.4 nM None
None NON-PROTEIN TARGET Potency 18821.2 nM None
None No relevant target LogD7.4 2.9 None 10.6019/CHEMBL3301361
None No relevant target Solubility 302000.0 nM 10.6019/CHEMBL3301361
None Peritoneal macrophage cell Inhibition nan % 10.1016/j.bmc.2012.06.043
None Unchecked Activity 94.0 % 10.1042/bj20070797
None Unchecked Activity 97.0 % 10.1042/bj20070797
None Unchecked Activity nan None 10.1021/acs.jnatprod.2c00502
None Unchecked EC50 1500.0 nM 10.1021/jm9011142
None Unchecked FC 2.0 None 10.1021/acs.jnatprod.2c00502
None Unchecked IC50 1000.0 nM 10.1016/j.bmc.2018.12.032
None Unchecked IC50 1300.0 nM 10.1016/j.bmcl.2021.127822
None Unchecked IC50 1300.0 nM 10.1021/jm301522m
None Unchecked IC50 1400.0 nM 10.1016/s0960-894x(01)00099-3
None Unchecked IC50 1400.0 nM 10.1039/C2MD20044A
None Unchecked IC50 3000.0 nM 10.1074/jbc.m704741200
None Unchecked IC50 3500.0 nM 10.1021/ml500354e
None Unchecked IC50 4500.0 nM 10.1021/acs.jmedchem.2c01070
None Unchecked IC50 4600.0 nM 10.1021/acs.jmedchem.2c01070
None Unchecked IC50 4800.0 nM 10.1021/acs.jnatprod.7b00619
None Unchecked IC50 6900.0 nM 10.1016/j.bmc.2008.02.046
None Unchecked IC50 7000.0 nM 10.1016/j.bmcl.2009.08.087
None Unchecked IC50 10000.0 nM 10.1016/j.bmc.2008.02.046
None Unchecked IC50 10404.0 nM None
None Unchecked IC50 21411.0 nM None
None Unchecked IC50 25000.0 nM 10.1021/acs.jmedchem.8b00329
None Unchecked IC50 57300.0 nM 10.1016/j.ejmech.2020.113016
None Unchecked IC50 nan None None
None Unchecked Inhibition 40.0 % 10.1016/j.bmcl.2008.04.078
None Unchecked Inhibition 40.0 % 10.1016/j.bmcl.2009.08.087
None Unchecked Inhibition 44.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 70.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 83.94 % 10.1016/j.bmc.2008.02.046
None Unchecked Inhibition 91.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 93.4 % 10.1016/j.bmcl.2021.127822
None Unchecked Inhibition 101.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 103.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition nan % 10.1016/j.bmc.2010.12.006
None Unchecked Inhibition nan % 10.1016/j.bmc.2012.06.043
None Unchecked Inhibition nan % 10.1016/j.bmcl.2012.05.013
None Unchecked Inhibition nan % 10.1016/j.bmcl.2012.07.031
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.2c00502
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.7b00384
None Unchecked Inhibition nan % 10.1021/np200631v
None Unchecked Inhibition nan % 10.1021/np400800h
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ki 17446.0 nM None
None Unchecked Ki 1400000.0 nM 10.1016/j.bmc.2008.02.046
None Unchecked Ki nan None None
None Unchecked Potency 2592.9 nM None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 14125.4 nM None
None Unchecked Potency 18356.4 nM None
None Unchecked Potency 23109.3 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Ratio IC50 3.0 None 10.1016/j.bmc.2006.09.047
None Unchecked Ratio IC50 nan None 10.1016/j.bmc.2015.01.052

Metabolism Information