2-phenyl-1H-perimidine
AlkaPlorer ID: AK273443
Synonym: None
IUPAC Name: 2-phenyl-1H-perimidine
Structure
SMILES: C1=CC=C(C2=NC3=CC=CC4=CC=CC(=C34)N2)C=C1
InChI: InChI=1S/C17H12N2/c1-2-6-13(7-3-1)17-18-14-10-4-8-12-9-5-11-15(19-17)16(12)14/h1-11H,(H,18,19)
InChIKey: KXLJLJJNISGKPN-UHFFFAOYSA-N
Reference
A Bioassay for Inhibition of Serotonin Release from Bovine Platelets
PubChem CID: 376354
CAS: 15666-84-9
COCONUT: CNP0454241
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 244.297
TPSA？: 24.39
MolLogP？: 4.343600000000002
Number of H-Donors: 1
Number of H-Acceptors: 2
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Escherichia coli K-12 | Beta-lactamase AmpC | Potency | 35481.3 | nM | None |
| Homo sapiens | 786-0 | GI50 | 42756.29 | nM | None |
| Homo sapiens | A498 | GI50 | 100000.0 | nM | None |
| Homo sapiens | A549 | GI50 | 56885.29 | nM | None |
| Homo sapiens | ACHN | GI50 | 26181.83 | nM | None |
| Homo sapiens | BT-549 | GI50 | 44157.04 | nM | None |
| Homo sapiens | CAKI-1 | GI50 | 37239.17 | nM | None |
| Homo sapiens | CCRF-CEM | GI50 | 3819.44 | nM | None |
| Homo sapiens | COLO 205 | GI50 | 18620.87 | nM | None |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 12589.3 | nM | None |
| Homo sapiens | DU-145 | GI50 | 90157.11 | nM | None |
| Homo sapiens | EKVX | GI50 | 51050.5 | nM | None |
| Homo sapiens | HCC 2998 | GI50 | 43853.07 | nM | None |
| Homo sapiens | HCT-116 | GI50 | 23280.91 | nM | None |
| Homo sapiens | HCT-15 | GI50 | 28641.78 | nM | None |
| Homo sapiens | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Potency | 8912.5 | nM | None |
| Homo sapiens | HL-60 | GI50 | 2884.03 | nM | None |
| Homo sapiens | HOP-62 | GI50 | 100000.0 | nM | None |
| Homo sapiens | HOP-92 | GI50 | 24378.11 | nM | None |
| Homo sapiens | Hs-578T | GI50 | 58076.44 | nM | None |
| Homo sapiens | HT-29 | GI50 | 43451.02 | nM | None |
| Homo sapiens | IGROV-1 | GI50 | 54575.79 | nM | None |
| Homo sapiens | K562 | GI50 | 31988.95 | nM | None |
| Homo sapiens | KM12 | GI50 | 28313.92 | nM | None |
| Homo sapiens | LOX IMVI | GI50 | 23496.33 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4D-like | Potency | 3981.1 | nM | None |
| Homo sapiens | Lysosomal alpha-glucosidase | Potency | 39506.8 | nM | None |
| Homo sapiens | M14 | GI50 | 44668.36 | nM | None |
| Homo sapiens | Malme-3M | GI50 | 43451.02 | nM | None |
| Homo sapiens | MCF7 | GI50 | 40831.94 | nM | None |
| Homo sapiens | MDA-MB-231 | GI50 | 19724.23 | nM | None |
| Homo sapiens | MDA-MB-435 | GI50 | 48752.85 | nM | None |
| Homo sapiens | MDA-N | GI50 | 45289.76 | nM | None |
| Homo sapiens | Menin/Histone-lysine N-methyltransferase MLL | Potency | 31622.8 | nM | None |
| Homo sapiens | Menin/Histone-lysine N-methyltransferase MLL | Potency | 39810.7 | nM | None |
| Homo sapiens | Microtubule-associated protein tau | Potency | 5011.9 | nM | None |
| Homo sapiens | Microtubule-associated protein tau | Potency | 14125.4 | nM | None |
| Homo sapiens | MOLT-4 | GI50 | 18663.8 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 6309.6 | nM | None |
| Homo sapiens | NCI/ADR-RES | GI50 | 30831.88 | nM | None |
| Homo sapiens | NCI-H226 | GI50 | 78342.96 | nM | None |
| Homo sapiens | NCI-H23 | GI50 | 60534.09 | nM | None |
| Homo sapiens | NCI-H322M | GI50 | 100000.0 | nM | None |
| Homo sapiens | NCI-H460 | GI50 | 57016.43 | nM | None |
| Homo sapiens | NCI-H522 | GI50 | 12161.86 | nM | None |
| Homo sapiens | OVCAR-3 | GI50 | 23659.2 | nM | None |
| Homo sapiens | OVCAR-4 | GI50 | 18663.8 | nM | None |
| Homo sapiens | OVCAR-5 | GI50 | 69502.43 | nM | None |
| Homo sapiens | OVCAR-8 | GI50 | 35481.34 | nM | None |
| Homo sapiens | PC-3 | GI50 | 22803.42 | nM | None |
| Homo sapiens | Prelamin-A/C | Potency | 3548.1 | nM | None |
| Homo sapiens | RPMI-8226 | GI50 | 22594.36 | nM | None |
| Homo sapiens | RXF 393 | GI50 | 21978.6 | nM | None |
| Homo sapiens | SF-268 | GI50 | 44771.33 | nM | None |
| Homo sapiens | SF-295 | GI50 | 58210.32 | nM | None |
| Homo sapiens | SF-539 | GI50 | 56234.13 | nM | None |
| Homo sapiens | SK-MEL-2 | GI50 | 46344.69 | nM | None |
| Homo sapiens | SK-MEL-28 | GI50 | 79067.86 | nM | None |
| Homo sapiens | SK-MEL-5 | GI50 | 56234.13 | nM | None |
| Homo sapiens | SK-OV-3 | GI50 | 100000.0 | nM | None |
| Homo sapiens | SN12C | GI50 | 78704.58 | nM | None |
| Homo sapiens | SNB-19 | GI50 | 100000.0 | nM | None |
| Homo sapiens | SNB-75 | GI50 | 90573.26 | nM | None |
| Homo sapiens | SR | GI50 | 9484.18 | nM | None |
| Homo sapiens | SW-620 | GI50 | 20370.42 | nM | None |
| Homo sapiens | T47D | GI50 | 4634.47 | nM | None |
| Homo sapiens | TAR DNA-binding protein 43 | Potency | 22387.2 | nM | None |
| Homo sapiens | TK-10 | GI50 | 48865.24 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 7307.8 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 11582.1 | nM | None |
| Homo sapiens | U-251 | GI50 | 100000.0 | nM | None |
| Homo sapiens | UACC-257 | GI50 | 69502.43 | nM | None |
| Homo sapiens | UACC-62 | GI50 | 37931.5 | nM | None |
| Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 | Potency | 35481.3 | nM | None |
| Homo sapiens | UO-31 | GI50 | 21330.45 | nM | None |
| Photinus pyralis | Luciferin 4-monooxygenase | Potency | 15101.4 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 11689.1 | nM | None |
| Schistosoma mansoni | Thioredoxin glutathione reductase | Potency | 35481.3 | nM | None |
| Trypanosoma cruzi | Cruzipain | Potency | 31622.8 | nM | None |
| None | Unchecked | Potency | 2818.4 | nM | None |
| None | Unchecked | Potency | 39810.7 | nM | None |