Molecule

3,4-Diphenyl-1H-pyrrole-2,5-dione

AlkaPlorer ID: AK276092

Synonym: Diphenylmaleimide

IUPAC Name: 3,4-diphenylpyrrole-2,5-dione

Structure

SMILES: O=C1NC(=O)C(C2=CC=CC=C2)=C1C1=CC=CC=C1

InChI: InChI=1S/C16H11NO2/c18-15-13(11-7-3-1-4-8-11)14(16(19)17-15)12-9-5-2-6-10-12/h1-10H,(H,17,18,19)

InChIKey: WADCPEMKIBAJHH-UHFFFAOYSA-N

Reference

Hyaluronidase Inhibitors from “Cimicifugae Rhizoma” (a Mixture of the Rhizomes of <i>Cimicifuga dahurica</i> and <i>C. heracleifolia</i>)

PubChem CID: 2752461

CAS: 31295-36-0

SuperNatural Ⅲ: SN0404751

COCONUT: CNP0029046

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain

Properties Information

Molecule Weight: 249.269

TPSA？: 46.17

MolLogP？: 2.2538

Number of H-Donors: 1

Number of H-Acceptors: 2

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Gallus gallus	Gallus gallus	Inhibition	11.3	%	10.1021/jm0580297
Homo sapiens	CDK6/cyclin D1	Inhibition	53.0	%	10.1021/jm0580297
Homo sapiens	CDK6/cyclin D1	Inhibition	65.0	%	10.1021/jm0580297
Homo sapiens	Cyclin-dependent kinase 1/cyclin B	Inhibition	100.0	%	10.1021/jm0580297
Homo sapiens	Cyclin-dependent kinase 1/cyclin B	Inhibition	106.0	%	10.1021/jm0580297
Homo sapiens	Cyclin-dependent kinase 2/cyclin E	Inhibition	79.0	%	10.1021/jm0580297
Homo sapiens	Cyclin-dependent kinase 2/cyclin E	Inhibition	93.0	%	10.1021/jm0580297
Homo sapiens	Cyclin-dependent kinase 4/cyclin D1	Inhibition	88.0	%	10.1021/jm0580297
Homo sapiens	Cyclin-dependent kinase 4/cyclin D1	Inhibition	94.0	%	10.1021/jm0580297
Homo sapiens	Epidermal growth factor receptor erbB1	Inhibition	93.0	%	10.1021/jm0580297
Homo sapiens	Epidermal growth factor receptor erbB1	Inhibition	106.0	%	10.1021/jm0580297
Homo sapiens	Protein kinase C iota	Inhibition	96.0	%	10.1021/jm0580297
Homo sapiens	Protein kinase C iota	Inhibition	97.0	%	10.1021/jm0580297
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	Inhibition	94.0	%	10.1021/jm0580297
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	Inhibition	100.0	%	10.1021/jm0580297
Homo sapiens	Tyrosine-protein kinase TIE-2	Inhibition	10.0	%	10.1021/jm0580297
Homo sapiens	Tyrosine-protein kinase TIE-2	Inhibition	99.0	%	10.1021/jm0580297
Homo sapiens	Vascular endothelial growth factor receptor 2	Inhibition	81.0	%	10.1021/jm0580297
Homo sapiens	Vascular endothelial growth factor receptor 2	Inhibition	88.0	%	10.1021/jm0580297
Mus musculus	Protein kinase C alpha	Inhibition	82.0	%	10.1021/jm0580297
Mus musculus	Protein kinase C alpha	Inhibition	102.0	%	10.1021/jm0580297
Mus musculus	Protein kinase C epsilon	Inhibition	98.0	%	10.1021/jm0580297
Mus musculus	RAW264.7	IC50	27940.0	nM	10.1016/j.bmcl.2009.11.067
Mus musculus	RAW264.7	IC50	269900.0	nM	10.1016/j.bmcl.2009.11.067
Rattus norvegicus	Protein kinase C gamma	Inhibition	89.0	%	10.1021/jm0580297
Rattus norvegicus	Protein kinase C gamma	Inhibition	105.0	%	10.1021/jm0580297
Sus scrofa	Tubulin	Inhibition	nan	%	10.1021/jm0580297