N,4-diphenyl-1,3-thiazol-2-amine
AlkaPlorer ID: AK277470
Synonym: None
IUPAC Name: N,4-diphenyl-1,3-thiazol-2-amine
Structure
SMILES: C1=CC=C(NC2=NC(C3=CC=CC=C3)=CS2)C=C1
InChI: InChI=1S/C15H12N2S/c1-3-7-12(8-4-1)14-11-18-15(17-14)16-13-9-5-2-6-10-13/h1-11H,(H,16,17)
InChIKey: FAXWKQAPUYLLPC-UHFFFAOYSA-N
Reference
Cytotoxic 4-Phenylcoumarins from the Leaves of <i>Marila </i><i>p</i><i>luricostata</i>
PubChem CID: 954216
CAS: 1843-16-9
SuperNatural Ⅲ: SN0080790
COCONUT: CNP0151541
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 252.34200000000004
TPSA？: 24.92
MolLogP？: 4.553700000000002
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | KB | CC50 | nan | None | 10.1016/j.ejmech.2015.08.013 |
| Homo sapiens | Small conductance calcium-activated potassium channel protein 3 | IC50 | 30000.0 | nM | 10.1016/j.bmcl.2008.08.023 |
| Homo sapiens | Small conductance calcium-activated potassium channel protein 3 | Inhibition | 18.0 | % | 10.1016/j.bmcl.2008.08.023 |
| Leishmania donovani | Leishmania donovani | IC50 | 100000.0 | nM | 10.1016/j.ejmech.2015.08.013 |
| Sus scrofa | Fructose-1,6-bisphosphatase | IC50 | 2500000.0 | nM | 10.1016/j.bmc.2009.04.030 |
| None | ADMET | Drug metabolism | nan | None | 10.1016/j.ejmech.2015.08.013 |
| None | No relevant target | solubility | nan | None | 10.1016/j.ejmech.2015.08.013 |