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name Structure Reference Source Properties Activities Metabolism

Damgo

AlkaPlorer ID: AK279570

Synonym: None

IUPAC Name: (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide

Structure

SMILES: C[C@@H](N=C(O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(O)=NCCO

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InChI: InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1

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InChIKey: HPZJMUBDEAMBFI-WTNAPCKOSA-N

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Reference

PubChem CID: 5462471

CAS: 78123-71-4

NPASS: NPC488041

Source

Species Genus Family Order Class Phylum Kingdom Domain
Stephania japonica Stephania Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 513.5950000000004

TPSA？: 184.56

MolLogP？: 1.5820000000000007

Number of H-Donors: 6

Number of H-Acceptors: 7

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Cavia porcellus Cavia porcellus EC50 11.8 nM 10.1016/0960-894X(95)00325-N
Cavia porcellus Cavia porcellus EC50 36.2 nM 10.1021/jm040867y
Cavia porcellus Cavia porcellus Efficacy 61.0 % 10.1021/jm040867y
Cavia porcellus Cavia porcellus IC50 8.25 nM 10.1016/s0960-894x(99)00085-2
Cavia porcellus Cavia porcellus IC50 8.25 nM 10.1021/jm990951r
Cavia porcellus Cavia porcellus IC50 18.0 nM 10.1021/jm00112a018
Cavia porcellus Cavia porcellus IC50 28.3 nM 10.1021/jm00123a035
Cavia porcellus Cavia porcellus Ke 0.8 nM 10.1021/jm00123a035
Cavia porcellus Cavia porcellus Ke 1.6 nM 10.1016/0960-894X(95)00325-N
Cavia porcellus Cavia porcellus Ke 25.3 nM 10.1016/s0960-894x(99)00085-2
Cavia porcellus Cavia porcellus Relative potency 1.8 % 10.1021/jm00112a018
Cavia porcellus Cavia porcellus Relative potency 8.69 None 10.1021/jm00123a035
Cavia porcellus Kappa opioid receptor Dose ratio 2.5 None 10.1021/jm00079a005
Cavia porcellus Kappa opioid receptor EC50 nan None 10.1021/jm030311v
Cavia porcellus Kappa opioid receptor ED50 509.0 nM 10.1021/jm000427g
Cavia porcellus Kappa opioid receptor Emax 135.0 nM 10.1016/s0960-894x(99)00613-7
Cavia porcellus Kappa opioid receptor Emax 135.0 nM 10.1021/jm000427g
Cavia porcellus Kappa opioid receptor Emax 135.0 None 10.1016/s0960-894x(99)00525-9
Cavia porcellus Kappa opioid receptor Kd 509.0 nM 10.1016/s0960-894x(99)00525-9
Cavia porcellus Kappa opioid receptor Kd 509.0 nM 10.1016/s0960-894x(99)00613-7
Cavia porcellus Kappa opioid receptor Ki 1841.0 nM 10.1016/j.bmcl.2006.05.060
Cavia porcellus Kappa opioid receptor Ki 5000.0 nM 10.1016/j.bmc.2010.06.005
Cavia porcellus Kappa opioid receptor Ki 5820.0 nM 10.1021/jm030311v
Cavia porcellus Kappa opioid receptor Ki nan None 10.1021/jm030311v
Cavia porcellus Kappa opioid receptor NR nan None 10.1021/jm990951r
Cavia porcellus Mu opioid receptor EC50 158.49 nM 10.1016/j.bmc.2016.05.005
Cavia porcellus Mu opioid receptor EC50 414.0 None 10.1021/jm030311v
Cavia porcellus Mu opioid receptor ED50 592.0 nM 10.1021/jm000427g
Cavia porcellus Mu opioid receptor Emax 100.0 % 10.1021/jm030311v
Cavia porcellus Mu opioid receptor Emax 123.0 nM 10.1016/s0960-894x(99)00613-7
Cavia porcellus Mu opioid receptor Emax 123.0 nM 10.1021/jm000427g
Cavia porcellus Mu opioid receptor Emax 123.0 None 10.1016/s0960-894x(99)00525-9
Cavia porcellus Mu opioid receptor Emax nan None 10.1016/s0960-894x(99)00525-9
Cavia porcellus Mu opioid receptor Emax nan None 10.1016/s0960-894x(99)00613-7
Cavia porcellus Mu opioid receptor IC50 11.5 nM 10.1021/jm00397a019
Cavia porcellus Mu opioid receptor IC50 28.3 nM 10.1016/j.bmcl.2018.05.015
Cavia porcellus Mu opioid receptor Kd 592.0 nM 10.1016/s0960-894x(99)00525-9
Cavia porcellus Mu opioid receptor Kd 592.0 nM 10.1016/s0960-894x(99)00613-7
Cavia porcellus Mu opioid receptor Ke 25.3 nM 10.1021/jm990951r
Cavia porcellus Mu opioid receptor Ki 0.99 nM 10.1016/s0960-894x(98)00476-4
Cavia porcellus Mu opioid receptor Ki 1.1 nM 10.1016/j.bmcl.2006.05.060
Cavia porcellus Mu opioid receptor Ki nan None 10.1021/jm030311v
Cavia porcellus Mu opioid receptor NS nan None 10.1021/jm000427g
Cavia porcellus Mu opioid receptor pD2 6.2 None 10.1016/j.bmc.2016.08.057
Cavia porcellus Nociceptin receptor Ki 26.9 nM 10.1016/j.bmcl.2006.05.060
Homo sapiens Adenosine A1 receptor Ki 100000.0 nM 10.1016/j.bmcl.2009.09.112
Homo sapiens Cannabinoid CB1 receptor Activity 0.68 None 10.1073/pnas.0706980105
Homo sapiens Cholecystokinin B receptor Bmax 9.5 pmol 10.1021/jm800174p
Homo sapiens Cholecystokinin B receptor EC50 2.66 nM 10.1021/jm800174p
Homo sapiens Cholecystokinin B receptor Ki 11.0 nM 10.1021/jm800174p
Homo sapiens Delta opioid receptor EC50 6.86 nM 10.1021/jm2003238
Homo sapiens Delta opioid receptor EC50 400.0 nM 10.1016/j.bmcl.2013.06.084
Homo sapiens Delta opioid receptor EC50 10000.0 nM 10.1021/jm021073r
Homo sapiens Delta opioid receptor EC50 nan nM 10.1021/jm030311v
Homo sapiens Delta opioid receptor EC50 nan None 10.1021/acs.jmedchem.0c00901
Homo sapiens Delta opioid receptor EC50 nan None 10.1021/acs.jmedchem.6b01235
Homo sapiens Delta opioid receptor EC50 nan None 10.1039/d0md00104j
Homo sapiens Delta opioid receptor ED50 1850.0 nM 10.1021/jm000427g
Homo sapiens Delta opioid receptor Emax 124.0 nM 10.1016/s0960-894x(99)00613-7
Homo sapiens Delta opioid receptor Emax 124.0 nM 10.1021/jm000427g
Homo sapiens Delta opioid receptor Emax 124.0 None 10.1016/s0960-894x(99)00525-9
Homo sapiens Delta opioid receptor Emax nan None 10.1021/acs.jmedchem.0c00901
Homo sapiens Delta opioid receptor Emax nan None 10.1039/d0md00104j
Homo sapiens Delta opioid receptor IC50 1.445 nM 10.1016/j.bmc.2009.08.035
Homo sapiens Delta opioid receptor IC50 nan None 10.1016/j.bmc.2010.06.005
Homo sapiens Delta opioid receptor Imax nan None 10.1016/j.bmc.2010.06.005
Homo sapiens Delta opioid receptor Inhibition 99.0 % 10.1016/j.bmcl.2013.06.084
Homo sapiens Delta opioid receptor Inhibition nan % 10.1016/j.bmc.2014.02.047
Homo sapiens Delta opioid receptor Kd 1850.0 nM 10.1016/s0960-894x(99)00525-9
Homo sapiens Delta opioid receptor Kd 1850.0 nM 10.1016/s0960-894x(99)00613-7
Homo sapiens Delta opioid receptor Ki 0.66 nM 10.1016/j.bmc.2009.08.035
Homo sapiens Delta opioid receptor Ki 127.0 nM 10.1016/j.bmcl.2006.05.060
Homo sapiens Delta opioid receptor Ki 290.0 nM 10.1016/s0960-894x(03)00194-x
Homo sapiens Delta opioid receptor Ki 300.0 nM 10.1021/jm021073r
Homo sapiens Delta opioid receptor Ki 300.0 nM 10.1021/jm2003238
Homo sapiens Delta opioid receptor Ki 567.0 nM 10.1016/s0960-894x(98)00476-4
Homo sapiens Delta opioid receptor Ki 990.0 nM 10.1021/acs.jmedchem.5b00014
Homo sapiens Delta opioid receptor Ki 1500.0 nM 10.1016/j.bmc.2013.02.060
Homo sapiens Delta opioid receptor Ki 1500.0 nM 10.1016/j.ejmech.2012.01.025
Homo sapiens Delta opioid receptor Ki 1500.0 nM 10.1016/j.ejmech.2013.06.030
Homo sapiens Delta opioid receptor Ki 1500.0 nM 10.1016/j.ejmech.2015.01.025
Homo sapiens Delta opioid receptor Ki 2000.0 nM 10.1016/j.bmcl.2004.08.001
Homo sapiens Delta opioid receptor Ki 10000.0 nM 10.1021/jm970861r
Homo sapiens Delta opioid receptor Ki nan nM 10.1021/jm030311v
Homo sapiens Delta opioid receptor Ki nan None 10.1016/j.bmc.2016.08.057
Homo sapiens Delta opioid receptor Ki nan None 10.1016/j.bmcl.2013.03.111
Homo sapiens Delta opioid receptor Ki nan None 10.1016/j.bmcl.2022.128860
Homo sapiens Delta opioid receptor Ki nan None 10.1016/j.ejmech.2014.07.077
Homo sapiens Delta opioid receptor Ki nan None 10.1021/acs.jmedchem.1c00256
Homo sapiens Delta opioid receptor Ki nan None 10.1021/acs.jmedchem.9b01465
Homo sapiens Delta opioid receptor Log EC50 nan None 10.1021/jm050921q
Homo sapiens Delta opioid receptor Log IC50 nan None 10.1021/jm050921q
Homo sapiens Delta opioid receptor Stimulation 10000.0 % 10.1021/jm021073r
Homo sapiens Kappa opioid receptor Activity 100.0 % 10.1021/jm2003238
Homo sapiens Kappa opioid receptor EC50 4000.0 nM 10.1016/j.bmcl.2013.06.084
Homo sapiens Kappa opioid receptor EC50 4365.0 nM 10.1021/jm021073r
Homo sapiens Kappa opioid receptor EC50 10000.0 nM 10.1021/acs.jmedchem.6b01235
Homo sapiens Kappa opioid receptor EC50 nan None 10.1016/j.ejmech.2014.07.077
Homo sapiens Kappa opioid receptor EC50 nan None 10.1016/j.ejmech.2020.112070
Homo sapiens Kappa opioid receptor EC50 nan None 10.1021/jm701162g
Homo sapiens Kappa opioid receptor EC50 nan None 10.1039/d0md00104j
Homo sapiens Kappa opioid receptor ED50 8940.0 nM 10.1021/jm901503e
Homo sapiens Kappa opioid receptor Emax 0.0 % 10.1021/acs.jmedchem.6b01235
Homo sapiens Kappa opioid receptor Emax 69.0 % 10.1021/jm901503e
Homo sapiens Kappa opioid receptor Emax nan None 10.1016/j.ejmech.2020.112070
Homo sapiens Kappa opioid receptor Emax nan None 10.1021/jm701162g
Homo sapiens Kappa opioid receptor Emax nan None 10.1039/d0md00104j
Homo sapiens Kappa opioid receptor Inhibition 66.0 % 10.1016/j.bmcl.2013.06.084
Homo sapiens Kappa opioid receptor Ki 270.0 nM 10.1021/acs.jmedchem.5b00014
Homo sapiens Kappa opioid receptor Ki 305.0 nM 10.1021/jm021073r
Homo sapiens Kappa opioid receptor Ki 306.0 nM 10.1021/jm2003238
Homo sapiens Kappa opioid receptor Ki 1000.0 nM 10.1016/s0960-894x(03)00194-x
Homo sapiens Kappa opioid receptor Ki 2000.0 nM 10.1016/j.bmcl.2004.08.001
Homo sapiens Kappa opioid receptor Ki 10000.0 nM 10.1021/jm970861r
Homo sapiens Kappa opioid receptor Ki nan None 10.1016/j.bmcl.2013.03.111
Homo sapiens Kappa opioid receptor Ki nan None 10.1016/j.bmcl.2022.128860
Homo sapiens Kappa opioid receptor Ki nan None 10.1016/j.ejmech.2014.07.077
Homo sapiens Kappa opioid receptor Ki nan None 10.1016/j.ejmech.2015.01.025
Homo sapiens Kappa opioid receptor Ki nan None 10.1021/acs.jmedchem.9b01465
Homo sapiens Kappa opioid receptor Stimulation 62.0 % 10.1021/jm021073r
Homo sapiens Metastin receptor Ki nan None 10.1021/acs.jmedchem.1c00256
Homo sapiens MIA PaCa-2 GI nan None None
Homo sapiens Mu opioid receptor Activity 100.0 % 10.1021/jm2003238
Homo sapiens Mu opioid receptor Activity 366.0 % 10.1016/j.bmcl.2008.12.093
Homo sapiens Mu opioid receptor Activity nan None 10.1016/j.bmcl.2008.10.134
Homo sapiens Mu opioid receptor Activity nan None 10.1016/j.ejmech.2018.02.074
Homo sapiens Mu opioid receptor Activity nan None 10.1021/acs.jmedchem.6b00748
Homo sapiens Mu opioid receptor Activity nan None 10.1021/jm050577x
Homo sapiens Mu opioid receptor Activity nan None 10.1021/jm060278n
Homo sapiens Mu opioid receptor Activity nan None 10.1021/jm100135g
Homo sapiens Mu opioid receptor Activity nan None 10.1021/jm701162g
Homo sapiens Mu opioid receptor Bmax 9.2 pmol 10.1021/jm800174p
Homo sapiens Mu opioid receptor deltalog(Tau/KA) 0.0 None 10.1021/acs.jmedchem.8b01136
Homo sapiens Mu opioid receptor EC50 0.3 nM 10.1039/d0md00104j
Homo sapiens Mu opioid receptor EC50 0.49 nM 10.1021/acs.jmedchem.1c01273
Homo sapiens Mu opioid receptor EC50 0.6 nM 10.1021/acs.jmedchem.6b01235
Homo sapiens Mu opioid receptor EC50 1.0 nM 10.1074/jbc.m703272200
Homo sapiens Mu opioid receptor EC50 1.7 nM 10.1021/jm701440h
Homo sapiens Mu opioid receptor EC50 1.97 nM 10.1016/j.ejmech.2021.113986
Homo sapiens Mu opioid receptor EC50 2.0 nM 10.1016/j.ejmech.2022.114649
Homo sapiens Mu opioid receptor EC50 3.04 nM 10.1021/jm300664y
Homo sapiens Mu opioid receptor EC50 3.04 nM 10.1021/jm400195y
Homo sapiens Mu opioid receptor EC50 3.18 nM 10.1021/jm200894e
Homo sapiens Mu opioid receptor EC50 3.59 nM 10.1016/j.bmc.2021.116552
Homo sapiens Mu opioid receptor EC50 5.888 nM 10.1021/acs.jmedchem.1c01273
Homo sapiens Mu opioid receptor EC50 6.38 nM 10.1016/j.ejmech.2021.113986
Homo sapiens Mu opioid receptor EC50 7.2 nM 10.1021/acs.jmedchem.9b01963
Homo sapiens Mu opioid receptor EC50 7.5 nM 10.1016/j.bmc.2015.02.055
Homo sapiens Mu opioid receptor EC50 7.57 nM 10.1016/j.bmcl.2014.08.012
Homo sapiens Mu opioid receptor EC50 8.1 nM 10.1021/acs.jmedchem.1c00722
Homo sapiens Mu opioid receptor EC50 8.2 nM 10.1016/j.bmc.2009.07.069
Homo sapiens Mu opioid receptor EC50 9.61 nM 10.1016/j.bmc.2015.02.055
Homo sapiens Mu opioid receptor EC50 13.7 nM 10.1021/jm021073r
Homo sapiens Mu opioid receptor EC50 15.0 nM 10.1016/j.bmcl.2013.06.084
Homo sapiens Mu opioid receptor EC50 19.7 nM 10.1021/acsmedchemlett.8b00495
Homo sapiens Mu opioid receptor EC50 23.0 nM 10.1021/acsmedchemlett.9b00569
Homo sapiens Mu opioid receptor EC50 25.5 nM 10.1021/acs.jmedchem.0c00503
Homo sapiens Mu opioid receptor EC50 27.0 nM 10.1021/acs.jmedchem.0c00901
Homo sapiens Mu opioid receptor EC50 30.0 nM 10.1021/acsmedchemlett.5b00423
Homo sapiens Mu opioid receptor EC50 32.6 nM 10.1016/j.bmc.2014.02.047
Homo sapiens Mu opioid receptor EC50 33.0 nM 10.1021/acs.jmedchem.8b01136
Homo sapiens Mu opioid receptor EC50 35.3 nM 10.1021/jm2003238
Homo sapiens Mu opioid receptor EC50 40.0 nM 10.1021/jm701162g
Homo sapiens Mu opioid receptor EC50 42.0 nM 10.1021/acs.jmedchem.6b01235
Homo sapiens Mu opioid receptor EC50 44.1 nM 10.1039/d0md00104j
Homo sapiens Mu opioid receptor EC50 45.06 nM 10.1021/jm801272c
Homo sapiens Mu opioid receptor EC50 45.1 nM 10.1016/j.bmcl.2008.12.093
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1016/j.bmc.2008.03.066
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1016/j.bmcl.2007.09.082
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1016/j.bmcl.2008.10.134
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1016/j.bmcl.2008.11.076
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1016/j.bmcl.2009.02.078
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1016/j.bmcl.2012.10.081
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1016/j.bmcl.2013.01.117
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1021/jm060278n
Homo sapiens Mu opioid receptor EC50 55.0 nM 10.1021/jm3001086
Homo sapiens Mu opioid receptor EC50 60.9 nM 10.1016/j.ejmech.2021.113986
Homo sapiens Mu opioid receptor EC50 75.0 nM 10.1016/j.bmcl.2019.126748
Homo sapiens Mu opioid receptor EC50 83.0 nM 10.1021/acs.jmedchem.0c00901
Homo sapiens Mu opioid receptor EC50 88.0 nM 10.1016/j.bmcl.2019.05.045
Homo sapiens Mu opioid receptor EC50 110.0 nM 10.1016/j.bmc.2007.03.076
Homo sapiens Mu opioid receptor EC50 110.0 nM 10.1016/j.bmcl.2007.01.013
Homo sapiens Mu opioid receptor EC50 110.0 nM 10.1021/jm050577x
Homo sapiens Mu opioid receptor EC50 110.0 nM 10.1021/jm061327z
Homo sapiens Mu opioid receptor EC50 110.0 nM 10.1021/jm101542c
Homo sapiens Mu opioid receptor EC50 181.97 nM 10.1021/acs.jmedchem.1c01273
Homo sapiens Mu opioid receptor EC50 182.04 nM 10.1021/acs.jmedchem.1c01273
Homo sapiens Mu opioid receptor EC50 199.53 nM 10.1021/acs.jnatprod.0c01036
Homo sapiens Mu opioid receptor EC50 202.0 nM 10.1016/j.bmcl.2004.08.001
Homo sapiens Mu opioid receptor EC50 220.0 nM 10.1021/acs.jmedchem.8b01136
Homo sapiens Mu opioid receptor EC50 378.0 nM 10.1016/j.bmc.2014.02.015
Homo sapiens Mu opioid receptor EC50 nan None 10.1039/d0md00104j
Homo sapiens Mu opioid receptor ED50 34.0 nM 10.1016/j.bmc.2013.02.060
Homo sapiens Mu opioid receptor ED50 42.0 nM 10.1021/jm061325e
Homo sapiens Mu opioid receptor ED50 42.0 nM 10.1021/jm9004225
Homo sapiens Mu opioid receptor ED50 42.0 nM 10.1021/jm901503e
Homo sapiens Mu opioid receptor Emax 73.0 % 10.1021/jm200894e
Homo sapiens Mu opioid receptor Emax 95.0 % 10.1016/j.bmcl.2004.08.001
Homo sapiens Mu opioid receptor Emax 95.0 % 10.1021/acs.jmedchem.6b00420
Homo sapiens Mu opioid receptor Emax 95.0 % 10.1021/acs.jmedchem.8b00296
Homo sapiens Mu opioid receptor Emax 96.9 % 10.1016/j.ejmech.2021.113986
Homo sapiens Mu opioid receptor Emax 97.0 % 10.1021/acs.jmedchem.6b01235
Homo sapiens Mu opioid receptor Emax 98.1 % 10.1021/jm400195y
Homo sapiens Mu opioid receptor Emax 98.14 % 10.1021/jm300664y
Homo sapiens Mu opioid receptor Emax 100.0 % 10.1016/j.bmc.2013.02.060
Homo sapiens Mu opioid receptor Emax 100.0 % 10.1016/j.ejmech.2022.114649
Homo sapiens Mu opioid receptor Emax 100.0 % 10.1021/acs.jmedchem.1c01273
Homo sapiens Mu opioid receptor Emax 100.0 % 10.1021/acs.jmedchem.6b01235
Homo sapiens Mu opioid receptor Emax 100.0 % 10.1021/jm061325e
Homo sapiens Mu opioid receptor Emax 100.0 % 10.1021/jm901503e
Homo sapiens Mu opioid receptor Emax 101.5 % 10.1039/d0md00104j
Homo sapiens Mu opioid receptor Emax 102.9 % 10.1016/j.ejmech.2021.113986
Homo sapiens Mu opioid receptor Emax 103.0 % 10.1039/d0md00104j
Homo sapiens Mu opioid receptor Emax 116.0 % 10.1016/j.bmc.2008.03.066
Homo sapiens Mu opioid receptor Emax 116.0 % 10.1016/j.bmcl.2007.09.082
Homo sapiens Mu opioid receptor Emax 116.0 % 10.1016/j.bmcl.2008.10.134
Homo sapiens Mu opioid receptor Emax 116.0 % 10.1016/j.bmcl.2008.11.076
Homo sapiens Mu opioid receptor Emax 116.0 % 10.1016/j.bmcl.2012.10.081
Homo sapiens Mu opioid receptor Emax 116.0 % 10.1016/j.bmcl.2013.01.117
Homo sapiens Mu opioid receptor Emax 116.0 % 10.1021/jm060278n
Homo sapiens Mu opioid receptor Emax 120.0 % 10.1016/j.bmc.2007.03.076
Homo sapiens Mu opioid receptor Emax 120.0 % 10.1016/j.bmcl.2007.01.013
Homo sapiens Mu opioid receptor Emax 120.0 % 10.1016/j.bmcl.2009.02.078
Homo sapiens Mu opioid receptor Emax 120.0 % 10.1021/jm050577x
Homo sapiens Mu opioid receptor Emax 120.0 % 10.1021/jm061327z
Homo sapiens Mu opioid receptor Emax 120.0 % 10.1021/jm101542c
Homo sapiens Mu opioid receptor Emax 124.0 % 10.1016/j.bmc.2009.07.069
Homo sapiens Mu opioid receptor Emax 130.0 % 10.1021/jm3001086
Homo sapiens Mu opioid receptor Emax 205.0 % 10.1021/acs.jmedchem.1c00722
Homo sapiens Mu opioid receptor Emax 225.0 % 10.1021/acsmedchemlett.5b00423
Homo sapiens Mu opioid receptor Emax 366.5 % 10.1021/jm801272c
Homo sapiens Mu opioid receptor Emax 389.0 % 10.1021/jm7010222
Homo sapiens Mu opioid receptor Emax nan None 10.1039/d0md00104j
Homo sapiens Mu opioid receptor IC50 0.43 nM 10.1016/j.bmc.2016.03.006
Homo sapiens Mu opioid receptor IC50 0.43 nM 10.1016/j.bmc.2016.11.014
Homo sapiens Mu opioid receptor IC50 0.68 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Mu opioid receptor IC50 0.74 nM 10.1016/j.bmc.2013.03.016
Homo sapiens Mu opioid receptor IC50 0.7943 nM 10.1021/acsmedchemlett.9b00335
Homo sapiens Mu opioid receptor IC50 1.1 nM 10.1021/jm8007618
Homo sapiens Mu opioid receptor IC50 1.5 nM 10.1021/acs.jmedchem.8b00296
Homo sapiens Mu opioid receptor IC50 1.6 nM 10.1021/jm0155897
Homo sapiens Mu opioid receptor IC50 1.95 nM 10.1021/acsmedchemlett.9b00335
Homo sapiens Mu opioid receptor IC50 2.0 nM 10.1021/np100009j
Homo sapiens Mu opioid receptor IC50 2.5 nM 10.1021/acs.jmedchem.5b01899
Homo sapiens Mu opioid receptor IC50 2.5 nM 10.1021/jm701575k
Homo sapiens Mu opioid receptor IC50 3.18 nM 10.1016/j.bmc.2010.06.005
Homo sapiens Mu opioid receptor IC50 5.0 nM 10.1016/j.bmc.2014.07.012
Homo sapiens Mu opioid receptor IC50 5.1 nM 10.1016/j.ejmech.2016.09.003
Homo sapiens Mu opioid receptor IC50 19.3 nM 10.1021/acs.jmedchem.6b00420
Homo sapiens Mu opioid receptor IC50 20.0 nM 10.1016/j.bmcl.2013.01.025
Homo sapiens Mu opioid receptor IC50 nan None 10.1016/j.bmc.2007.03.076
Homo sapiens Mu opioid receptor IC50 nan None 10.1016/j.bmcl.2007.01.013
Homo sapiens Mu opioid receptor IC50 nan None 10.1016/j.bmcl.2008.11.076
Homo sapiens Mu opioid receptor IC50 nan None 10.1016/j.bmcl.2009.02.078
Homo sapiens Mu opioid receptor IC50 nan None 10.1021/jm050577x
Homo sapiens Mu opioid receptor IC50 nan None 10.1021/jm101542c
Homo sapiens Mu opioid receptor IC50 nan None 10.1021/jm3001086
Homo sapiens Mu opioid receptor Imax 73.0 % 10.1016/j.bmc.2010.06.005
Homo sapiens Mu opioid receptor Imax 82.4 % 10.1016/j.ejmech.2016.09.003
Homo sapiens Mu opioid receptor Imax nan None 10.1016/j.bmc.2007.03.076
Homo sapiens Mu opioid receptor Imax nan None 10.1016/j.bmcl.2007.01.013
Homo sapiens Mu opioid receptor Imax nan None 10.1016/j.bmcl.2008.11.076
Homo sapiens Mu opioid receptor Imax nan None 10.1021/jm050577x
Homo sapiens Mu opioid receptor Imax nan None 10.1021/jm101542c
Homo sapiens Mu opioid receptor Imax nan None 10.1021/jm3001086
Homo sapiens Mu opioid receptor Inhibition 4.0 % 10.1016/j.bmcl.2013.01.025
Homo sapiens Mu opioid receptor Inhibition 67.0 % 10.1016/j.ejmech.2018.02.074
Homo sapiens Mu opioid receptor Inhibition 85.0 % 10.1016/j.ejmech.2018.02.074
Homo sapiens Mu opioid receptor Inhibition 96.0 % 10.1016/j.bmcl.2013.06.084
Homo sapiens Mu opioid receptor Inhibition nan % 10.1016/j.bmc.2014.02.015
Homo sapiens Mu opioid receptor Inhibition nan % 10.1016/j.bmcl.2013.01.117
Homo sapiens Mu opioid receptor Inhibition nan % 10.1021/jm300664y
Homo sapiens Mu opioid receptor Inhibition nan % 10.1021/jm400195y
Homo sapiens Mu opioid receptor Ki 0.28 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Mu opioid receptor Ki 0.3162 nM 10.1021/acs.jnatprod.0c01036
Homo sapiens Mu opioid receptor Ki 0.35 nM 10.1021/acs.jnatprod.0c01036
Homo sapiens Mu opioid receptor Ki 0.403 nM 10.1021/acs.jnatprod.0c01055
Homo sapiens Mu opioid receptor Ki 0.41 nM 10.1021/acs.jmedchem.9b01465
Homo sapiens Mu opioid receptor Ki 0.44 nM 10.1021/jm8007618
Homo sapiens Mu opioid receptor Ki 0.45 nM 10.1016/j.bmcl.2011.05.008
Homo sapiens Mu opioid receptor Ki 0.5 nM 10.1021/jm021073r
Homo sapiens Mu opioid receptor Ki 0.53 nM 10.1016/s0960-894x(03)00194-x
Homo sapiens Mu opioid receptor Ki 0.56 nM 10.1021/acs.jmedchem.5b00014
Homo sapiens Mu opioid receptor Ki 0.6 nM 10.1016/j.bmc.2016.08.057
Homo sapiens Mu opioid receptor Ki 0.64 nM 10.1016/j.ejmech.2021.113986
Homo sapiens Mu opioid receptor Ki 0.7943 nM 10.1021/acs.jmedchem.2c01707
Homo sapiens Mu opioid receptor Ki 0.9 nM 10.1016/j.bmc.2009.07.069
Homo sapiens Mu opioid receptor Ki 0.9 nM 10.1016/j.bmcl.2013.03.111
Homo sapiens Mu opioid receptor Ki 0.9 nM 10.1021/acs.jmedchem.2c01707
Homo sapiens Mu opioid receptor Ki 1.2 nM 10.1016/j.bmc.2013.02.060
Homo sapiens Mu opioid receptor Ki 1.2 nM 10.1016/j.ejmech.2012.01.025
Homo sapiens Mu opioid receptor Ki 1.2 nM 10.1016/j.ejmech.2013.06.030
Homo sapiens Mu opioid receptor Ki 1.2 nM 10.1016/j.ejmech.2015.01.025
Homo sapiens Mu opioid receptor Ki 1.259 nM 10.1021/acs.jmedchem.5b01664
Homo sapiens Mu opioid receptor Ki 1.49 nM 10.1016/j.bmcl.2022.128860
Homo sapiens Mu opioid receptor Ki 1.5 nM 10.1016/j.bmcl.2016.11.057
Homo sapiens Mu opioid receptor Ki 1.5 nM 10.1021/acs.jmedchem.6b00420
Homo sapiens Mu opioid receptor Ki 1.5 nM 10.1021/acs.jmedchem.8b00296
Homo sapiens Mu opioid receptor Ki 1.5 nM 10.1021/jm301213s
Homo sapiens Mu opioid receptor Ki 1.5 nM 10.1021/jm5002925
Homo sapiens Mu opioid receptor Ki 1.55 nM 10.1016/j.bmcl.2011.05.008
Homo sapiens Mu opioid receptor Ki 1.59 nM 10.1021/jm2003238
Homo sapiens Mu opioid receptor Ki 2.3 nM 10.1016/j.ejmech.2014.07.077
Homo sapiens Mu opioid receptor Ki 2.96 nM 10.1016/j.bmc.2014.02.047
Homo sapiens Mu opioid receptor Ki 3.2 nM 10.1016/j.ejmech.2022.114649
Homo sapiens Mu opioid receptor Ki 3.34 nM 10.1016/j.bmcl.2011.05.008
Homo sapiens Mu opioid receptor Ki 3.715 nM 10.1016/j.bmc.2007.04.026
Homo sapiens Mu opioid receptor Ki 3.8 nM 10.1016/j.bmcl.2009.09.112
Homo sapiens Mu opioid receptor Ki 6.7 nM 10.1021/jm800174p
Homo sapiens Mu opioid receptor Ki 8.1 nM 10.1016/j.bmcl.2013.01.025
Homo sapiens Mu opioid receptor Ki 14.0 nM 10.1021/jm970861r
Homo sapiens Mu opioid receptor Ki 36.7 nM 10.1016/j.bmcl.2004.08.001
Homo sapiens Mu opioid receptor Ki 87.1 nM 10.1021/acs.jmedchem.5b01664
Homo sapiens Mu opioid receptor Ki 2187.76 nM 10.1021/acs.jmedchem.5b01664
Homo sapiens Mu opioid receptor Log10ED50 7.18 None 10.1021/jm7010222
Homo sapiens Mu opioid receptor Ratio 0.8 None 10.1016/j.bmc.2014.02.015
Homo sapiens Mu opioid receptor Ratio 1.0 None 10.1021/acs.jmedchem.8b01136
Homo sapiens Mu opioid receptor Ratio 1.0 None 10.1039/d0md00104j
Homo sapiens Mu opioid receptor Ratio nan None 10.1039/d0md00104j
Homo sapiens Mu opioid receptor Ratio IC50 0.4 None 10.1021/acsmedchemlett.9b00335
Homo sapiens Mu opioid receptor Stimulation 100.0 % 10.1021/jm021073r
Homo sapiens Nociceptin receptor EC50 nan nM 10.1016/j.bmcl.2004.08.001
Homo sapiens Nociceptin receptor Emax 0.0 % 10.1016/j.bmc.2009.07.069
Homo sapiens Nociceptin receptor Emax nan None 10.1016/j.bmcl.2004.08.001
Homo sapiens Nociceptin receptor Ki 10000.0 nM 10.1021/jm2003238
Homo sapiens Nociceptin receptor Ki nan nM 10.1016/j.bmcl.2004.08.001
Homo sapiens Nociceptin receptor Ki nan None 10.1021/acs.jmedchem.1c00256
Homo sapiens Opioid receptors; delta & kappa Selectivity 1.0 None 10.1021/jm021073r
Homo sapiens Opioid receptors; mu & delta EC50 9.0 nM 10.1021/acs.jmedchem.0c00901
Homo sapiens Opioid receptors; mu & delta EC50 11.0 nM 10.1021/acs.jmedchem.0c00901
Homo sapiens Opioid receptors; mu & delta IC50 76.1 nM 10.1021/jm00397a019
Homo sapiens Opioid receptors; mu & delta Ratio 570.0 None 10.1016/s0960-894x(98)00476-4
Homo sapiens Opioid receptors; mu & delta Ratio 1050.0 None 10.1021/jm00123a035
Homo sapiens Opioid receptors; mu & delta Selectivity 1.7 None 10.1021/jm021073r
Homo sapiens Opioid receptors; mu & delta Selectivity 6.66 None 10.1021/jm00397a019
Homo sapiens Opioid receptors; mu/kappa/delta IC50 14.0 nM 10.1021/jm00079a005
Homo sapiens P-glycoprotein 1 Km 43000.0 nM 10.1016/s0196-9781(01)00564-2
Homo sapiens Prolactin-releasing peptide Ki nan None 10.1021/acs.jmedchem.1c00256
Homo sapiens Pyroglutamylated RFamide peptide receptor Ki nan None 10.1021/acs.jmedchem.1c00256
Homo sapiens Sigma intracellular receptor 2 Ki nan None 10.1016/j.bmcl.2022.128860
Homo sapiens Sigma opioid receptor Ki nan None 10.1016/j.bmcl.2022.128860
Homo sapiens Solute carrier organic anion transporter family member 1A2 Activity nan None None
Homo sapiens UMSCC1 GI nan None None
Mus musculus Delta opioid receptor Activity nan None 10.1021/acs.jmedchem.0c00901
Mus musculus Delta opioid receptor EC50 nan None 10.1016/j.ejmech.2013.09.031
Mus musculus Delta opioid receptor IC50 950.0 nM 10.1016/j.bmcl.2018.05.015
Mus musculus Delta opioid receptor IC50 1533.0 nM 10.1016/j.bmcl.2018.05.015
Mus musculus Kappa opioid receptor EC50 4000.0 nM 10.1016/j.bmcl.2013.06.084
Mus musculus Kappa opioid receptor EC50 nan None 10.1016/j.ejmech.2013.09.031
Mus musculus Kappa opioid receptor EC50 nan None 10.1039/C6MD00450D
Mus musculus Kappa opioid receptor Emax nan None 10.1039/C6MD00450D
Mus musculus Kappa opioid receptor Inhibition 70.0 % 10.1016/j.bmcl.2013.06.084
Mus musculus Mu opioid receptor Activity nan None 10.1021/acs.jmedchem.0c00901
Mus musculus Mu opioid receptor EC50 5.0 nM 10.1016/j.bmcl.2013.06.084
Mus musculus Mu opioid receptor EC50 5.6 nM 10.1016/j.ejmech.2013.09.031
Mus musculus Mu opioid receptor EC50 6.31 nM 10.1021/acs.jmedchem.2c01707
Mus musculus Mu opioid receptor EC50 7.0 nM 10.1021/acs.jmedchem.2c01707
Mus musculus Mu opioid receptor EC50 19.0 nM 10.1021/acs.jmedchem.6b00748
Mus musculus Mu opioid receptor EC50 19.0 nM 10.1021/acs.jmedchem.9b01767
Mus musculus Mu opioid receptor EC50 19.0 nM 10.1039/C6MD00450D
Mus musculus Mu opioid receptor Emax 82.4 % 10.1021/acs.jmedchem.9b01767
Mus musculus Mu opioid receptor Emax 96.0 % 10.1021/acs.jmedchem.2c01707
Mus musculus Mu opioid receptor Emax nan None 10.1039/C6MD00450D
Mus musculus Mu opioid receptor IC50 1.39 nM 10.1016/j.bmcl.2018.05.015
Mus musculus Mu opioid receptor IC50 6.31 nM 10.1021/acs.jnatprod.0c01036
Mus musculus Mu opioid receptor IC50 6.6 nM 10.1021/acs.jnatprod.0c01036
Mus musculus Mu opioid receptor IC50 75.55 nM 10.1021/jm7010222
Mus musculus Mu opioid receptor Inhibition 95.0 % 10.1016/j.bmcl.2013.06.084
Mus musculus Mu opioid receptor Ki 0.83 nM 10.1016/j.bmcl.2014.08.012
Mus musculus Mu opioid receptor Ki 2.3 nM 10.1021/acs.jmedchem.1c00722
Mus musculus Mus musculus AD50 1.0 pM 10.1021/jm00397a019
Mus musculus Mus musculus Dose ratio 30.0 None 10.1021/jm00079a005
Mus musculus Mus musculus EC50 24.7 nM 10.1016/0960-894X(95)00325-N
Mus musculus Mus musculus IC50 51.5 nM 10.1021/jm00112a018
Mus musculus Mus musculus IC50 100.0 nM 10.1021/jm00397a019
Mus musculus Mus musculus IC50 178.0 nM 10.1016/s0960-894x(99)00085-2
Mus musculus Mus musculus IC50 950.0 nM 10.1021/jm00123a035
Mus musculus Mus musculus IC50 2400.0 nM 10.1021/jm00397a019
Mus musculus Mus musculus Ke 1.64 nM 10.1021/jm00123a035
Mus musculus Mus musculus Ke 1.9 nM 10.1016/0960-894X(95)00325-N
Mus musculus Mus musculus Ke nan None 10.1016/s0960-894x(99)00085-2
Mus musculus Mus musculus Relative potency 0.012 None 10.1021/jm00123a035
Mus musculus Mus musculus Relative potency 0.23 % 10.1021/jm00112a018
Mus musculus Opioid receptors; mu and delta EC50 2.69 nM 10.1021/acs.jmedchem.0c00901
Mus musculus Opioid receptors; mu and delta EC50 2.692 nM 10.1021/acs.jmedchem.0c00901
Rattus norvegicus Adenylate cyclase type II Inhibition 58.0 % 10.1021/jm000119i
Rattus norvegicus Delta opioid receptor EC50 49.0 nM 10.1016/j.bmcl.2018.05.015
Rattus norvegicus Delta opioid receptor EC50 nan None 10.1016/j.ejmech.2020.112070
Rattus norvegicus Delta opioid receptor Emax nan None 10.1016/j.ejmech.2020.112070
Rattus norvegicus Delta opioid receptor IC50 727.0 nM 10.1016/j.bmc.2007.03.009
Rattus norvegicus Delta opioid receptor Ki 180.4 nM 10.1021/jm00108a017
Rattus norvegicus Delta opioid receptor Ki 469.0 nM 10.1021/jm030311v
Rattus norvegicus Delta opioid receptor Ki 629.0 nM 10.1021/jm00112a018
Rattus norvegicus Delta opioid receptor Ki 700.0 nM 10.1021/jm00397a019
Rattus norvegicus Delta opioid receptor Ki 1280.0 nM 10.1021/jm00123a035
Rattus norvegicus Delta opioid receptor Ki 2670.0 nM 10.1016/j.bmc.2010.06.005
Rattus norvegicus Delta opioid receptor Ki 10000.0 nM 10.1016/j.ejmech.2013.07.044
Rattus norvegicus Delta opioid receptor Ki nan None 10.1021/jm7010222
Rattus norvegicus Delta opioid receptor Ratio 161.0 None 10.1021/jm00112a018
Rattus norvegicus Delta opioid receptor Relative potency 0.00198 None 10.1021/jm00123a035
Rattus norvegicus Kappa opioid receptor Ki nan None 10.1016/j.bmc.2016.08.057
Rattus norvegicus Mu opioid receptor Activity 76.0 % 10.1016/j.bmc.2009.07.024
Rattus norvegicus Mu opioid receptor Activity 101.0 % 10.1016/j.bmc.2017.02.064
Rattus norvegicus Mu opioid receptor Activity nan None 10.1021/jm300836n
Rattus norvegicus Mu opioid receptor Bmax 1207.0 fM mg-1 10.1016/s0960-894x(00)00187-6
Rattus norvegicus Mu opioid receptor EC50 0.26 nM 10.1016/j.bmcl.2018.05.015
Rattus norvegicus Mu opioid receptor EC50 8.06 nM 10.1016/j.ejmech.2020.112070
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1016/j.bmc.2009.08.035
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1021/jm050851n
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1021/jm050921q
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1021/jm061369n
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1021/jm100157m
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1021/jm100982d
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1021/jm101023r
Rattus norvegicus Mu opioid receptor EC50 36.31 nM 10.1021/jm900473p
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1016/j.bmc.2009.08.035
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm050851n
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm050921q
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm061369n
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm070332f
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm100157m
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm100982d
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm101023r
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm800389v
Rattus norvegicus Mu opioid receptor EC50 37.0 nM 10.1021/jm900473p
Rattus norvegicus Mu opioid receptor EC50 81.0 nM 10.1021/ml500241n
Rattus norvegicus Mu opioid receptor EC50 145.0 nM 10.1021/jm800223t
Rattus norvegicus Mu opioid receptor EC50 146.0 nM 10.1016/j.bmc.2017.02.064
Rattus norvegicus Mu opioid receptor EC50 214.0 nM 10.1021/jm101515v
Rattus norvegicus Mu opioid receptor EC50 485.0 nM 10.1021/jm300836n
Rattus norvegicus Mu opioid receptor Emax 119.0 % 10.1021/jm101515v
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1016/j.bmc.2009.08.035
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm050851n
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm050921q
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm061369n
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm070332f
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm100157m
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm100982d
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm101023r
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm800389v
Rattus norvegicus Mu opioid receptor Emax 150.0 % 10.1021/jm900473p
Rattus norvegicus Mu opioid receptor Emax 169.0 % 10.1021/jm7010222
Rattus norvegicus Mu opioid receptor Emax 170.0 % 10.1021/jm800223t
Rattus norvegicus Mu opioid receptor Emax 173.0 % 10.1021/jm300836n
Rattus norvegicus Mu opioid receptor Emax 178.0 % 10.1021/jm101515v
Rattus norvegicus Mu opioid receptor Emax 205.0 % 10.1016/j.ejmech.2020.112070
Rattus norvegicus Mu opioid receptor Emax 465.2 % 10.1021/ml500241n
Rattus norvegicus Mu opioid receptor IC50 1.01 nM 10.1016/j.bmc.2009.07.024
Rattus norvegicus Mu opioid receptor IC50 1.13 nM 10.1016/j.bmc.2007.03.009
Rattus norvegicus Mu opioid receptor IC50 3.0 nM 10.1016/s0960-894x(98)00349-7
Rattus norvegicus Mu opioid receptor IC50 3.5 nM 10.1021/jm990197+
Rattus norvegicus Mu opioid receptor IC50 9.89 nM 10.1016/s0960-894x(00)00562-x
Rattus norvegicus Mu opioid receptor IC50 9.9 nM 10.1021/jm011059z
Rattus norvegicus Mu opioid receptor IC50 9.9 nM 10.1021/jm0498811
Rattus norvegicus Mu opioid receptor IC50 36.31 nM 10.1016/j.bmc.2009.08.035
Rattus norvegicus Mu opioid receptor Ki 0.0024 nM 10.1021/jm7010222
Rattus norvegicus Mu opioid receptor Ki 0.53 nM 10.1016/s0960-894x(00)00187-6
Rattus norvegicus Mu opioid receptor Ki 0.66 nM 10.1021/jm00108a017
Rattus norvegicus Mu opioid receptor Ki 0.85 nM 10.1021/jm100157m
Rattus norvegicus Mu opioid receptor Ki 0.87 nM 10.1016/j.bmc.2010.06.005
Rattus norvegicus Mu opioid receptor Ki 0.9 nM 10.1021/acsmedchemlett.9b00549
Rattus norvegicus Mu opioid receptor Ki 1.0 nM 10.1021/ml500241n
Rattus norvegicus Mu opioid receptor Ki 1.16 nM 10.1016/j.ejmech.2019.02.043
Rattus norvegicus Mu opioid receptor Ki 1.22 nM 10.1021/jm00123a035
Rattus norvegicus Mu opioid receptor Ki 1.49 nM 10.1016/j.ejmech.2021.114091
Rattus norvegicus Mu opioid receptor Ki 1.6 nM 10.1021/jm011059z
Rattus norvegicus Mu opioid receptor Ki 1.6 nM 10.1021/jm0498811
Rattus norvegicus Mu opioid receptor Ki 1.64 nM 10.1016/s0960-894x(00)00562-x
Rattus norvegicus Mu opioid receptor Ki 1.7 nM 10.1016/j.ejmech.2013.07.044
Rattus norvegicus Mu opioid receptor Ki 2.3 nM 10.1016/j.ejmech.2020.112070
Rattus norvegicus Mu opioid receptor Ki 3.9 nM 10.1021/jm00112a018
Rattus norvegicus Mu opioid receptor Ki 3.9 nM 10.1021/jm00397a019
Rattus norvegicus Mu opioid receptor Ki 4.0 nM 10.1021/jm00043a007
Rattus norvegicus Mu opioid receptor Ki 6.1 nM 10.1021/jm030311v
Rattus norvegicus Mu opioid receptor Ki 16.0 nM 10.1016/j.bmc.2009.08.035
Rattus norvegicus Mu opioid receptor Log10ED50 6.71 None 10.1021/jm7010222
Rattus norvegicus Mu opioid receptor logEC50 -7.4 None 10.1021/jm070332f
Rattus norvegicus Mu opioid receptor logIC50 8.62 None 10.1016/j.ejmech.2013.07.044
Rattus norvegicus Mu opioid receptor Log IC50 nan None 10.1021/jm050921q
Rattus norvegicus Mu opioid receptor pEC50 7.4 nM 10.1021/jm800389v
Rattus norvegicus Mu opioid receptor Relative potency 7.73 None 10.1021/jm00123a035
Rattus norvegicus Neurokinin 1 receptor IC50 1000.0 nM 10.1021/jm990197+
Rattus norvegicus Opioid receptors; mu & delta Ki ratio 0.004 None 10.1021/jm00108a017
Rattus norvegicus Opioid receptors; mu & delta Ratio 0.01 None 10.1021/jm030311v
Rattus norvegicus Opioid receptors; mu & delta Ratio 179.0 None 10.1021/jm00397a019
Rattus norvegicus Opioid receptors; mu & delta Ratio IC50 643.0 None 10.1016/j.bmc.2007.03.009
Rattus norvegicus Rattus norvegicus ED50 0.14 ug 10.1021/jm970861r
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 9.67 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.18 % 10.6019/CHEMBL4495565
None NON-PROTEIN TARGET Ratio 33.6 None 10.1021/jm00123a035
None No relevant target T1/2 0.0992 hr 10.1016/j.ejmech.2021.113986
None Unchecked IC50 1.1 nM 10.1021/jm011059z
None Unchecked IC50 2.2 nM 10.1021/np50081a017
None Unchecked Ki 1.4 nM 10.1016/j.bmcl.2013.05.090
None Unchecked Ki 14.6 nM 10.1021/acs.jmedchem.1c00256
None Unchecked Ki nan None 10.1021/acs.jmedchem.1c00256
None Unchecked Ratio 2.84 None 10.1021/jm00112a018
None Unchecked Ratio 12.0 None 10.1021/jm030311v
None Unchecked Ratio EC50 10.0 None 10.1016/j.bmcl.2013.06.084
None Unchecked Ratio EC50 200.0 None 10.1016/j.bmcl.2013.06.084
None Unchecked Ratio EC50 16000.0 None 10.1021/acs.jmedchem.6b01235
None Unchecked Ratio Ki 50.0 None 10.1021/jm2003238
None Unchecked Ratio Ki 500.0 None 10.1021/acs.jmedchem.5b00014
None Unchecked Ratio Ki 2000.0 None 10.1021/acs.jmedchem.5b00014
None Unchecked Ratio Ki nan None 10.1016/j.bmc.2016.08.057
None Unchecked Ratio Ki nan None 10.1016/j.bmcl.2022.128860

Metabolism Information