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Sultiame

AlkaPlorer ID: AK282389

Synonym: None

IUPAC Name: 4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide

Structure

SMILES: NS(=O)(=O)C1=CC=C(N2CCCCS2(=O)=O)C=C1

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InChI: InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)

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InChIKey: HMHVCUVYZFYAJI-UHFFFAOYSA-N

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Reference

Marine natural products

PubChem CID: 5356

CAS: 61-56-3

COCONUT: CNP0448215

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 290.366

TPSA？: 97.54

MolLogP？: 0.2639999999999998

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Anopheles gambiae AGAP002992-PA Ki 265.0 nM 10.1016/j.bmc.2015.03.081
Astrosclera willeyana Astrosclerin-3 Ki 276.0 nM 10.1016/j.bmc.2012.01.007
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 1071.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1016/j.ejmech.2021.113444
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1021/jm301611m
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase I Ki 374.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase I Kinact 374.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase II Ki 7.0 nM 10.1016/j.ejmech.2021.113444
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2009.10.009
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2013.11.021
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2015.06.079
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2016.01.023
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1021/jm301611m
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase II Ki 9.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase II Kinact 7.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase III Kinact 6.3 10^5nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase IV Kinact 95.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase IX Ki 43.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase IX Kinact 43.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase VA Kinact 81.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase VB Kinact 91.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase VI Ki 134.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase VI Ki nan None 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase VI Kinact 134.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase VII Kinact 6.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase XII Kinact 56.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase XIV Kinact 1540.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor AC50 21000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Mus musculus Carbonic anhydrase 15 Ki 65.0 nM 10.1021/jm801267c
Mus musculus Carbonic anhydrase XIII Kinact 1450.0 nM 10.1016/j.bmcl.2007.06.044
Mycobacterium tuberculosis Carbonic anhydrase Ki 664.0 nM 10.1016/j.bmcl.2009.10.009
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 5160.0 nM 10.1021/jm9003126
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae S288c Carbonic anhydrase Ki 1020.0 nM 10.1016/j.bmc.2008.12.035
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 21.61 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.31 % 10.6019/CHEMBL4495565
Stylophora pistillata Alpha carbonic anhydrase Ki 45.2 nM 10.1016/j.bmc.2009.05.063
Stylophora pistillata Alpha carbonic anhydrase Ki 45.2 nM 10.1016/j.bmcl.2010.11.124
Stylophora pistillata Carbonic anhydrase Ki 123.0 nM 10.1016/j.bmcl.2010.11.124
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase Ki 7.8 nM 10.1016/j.bmcl.2015.11.104
Thalassiosira weissflogii Delta carbonic anhydrase Ki 169.0 nM 10.1016/j.bmcl.2013.11.021
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family Ki 432.0 nM 10.1016/j.bmcl.2015.11.104
None Unchecked Ac50 7.943 uM None
None Unchecked Ac50 10.0 uM None
None Unchecked AC50 7943.3 nM None
None Unchecked AC50 10000.0 nM None
None Unchecked Anticonvulsant activity nan None 10.1016/s0960-894x(03)00535-3
None Unchecked Ki 7.8 nM 10.1016/j.bmc.2012.07.024
None Unchecked Ki 49.5 nM 10.1016/j.bmcl.2015.10.074
None Unchecked Ki 68.0 nM 10.1021/acsmedchemlett.0c00417
None Unchecked Ki 71.9 nM 10.1021/jm4000616
None Unchecked Ki 82.4 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 82.4 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 82.4 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 88.4 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 88.4 nM 10.1016/j.ejmech.2021.113444
None Unchecked Ki 88.4 nM 10.1021/jm301611m
None Unchecked Ki 132.0 nM 10.1016/j.bmc.2014.12.009
None Unchecked Ki 138.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 380.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 424.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 424.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 424.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 424.0 nM 10.1016/j.bmcl.2013.11.030
None Unchecked Ki 424.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 455.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 455.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 455.0 nM 10.1016/j.ejmech.2021.113444
None Unchecked Ki 463.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 464.0 nM 10.1016/j.bmcl.2016.03.014
None Unchecked Ki 464.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 485.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 834.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 834.0 nM 10.1021/jm400939k
None Unchecked Ki 890.0 nM 10.1016/j.bmc.2009.05.002
None Unchecked Ki 898.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 898.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 1865.0 nM 10.1016/j.bmcl.2015.04.037
None Unchecked Ki 3140.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 4670.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 5160.0 nM 10.1021/jm9000488
None Unchecked Ki 6720.0 nM 10.1021/jm9003126
None Unchecked Ki 6800.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 8900.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 8900.0 nM 10.1016/j.ejmech.2021.113444
None Unchecked Ki 18900.0 nM 10.1016/j.bmcl.2016.07.060
None Unchecked Ki 50000.0 nM 10.1016/j.bmc.2017.05.007
None Unchecked Ki 50000.0 nM 10.1016/j.ejmech.2021.113444
None Unchecked Ki nan None 10.1016/j.bmc.2012.07.024
None Unchecked Ki nan None 10.1016/j.bmc.2014.04.006
None Unchecked Ki nan None 10.1016/j.bmc.2014.07.048
None Unchecked Ki nan None 10.1016/j.bmc.2015.02.045
None Unchecked Ki nan None 10.1016/j.bmcl.2013.11.030
None Unchecked Ki nan None 10.1016/j.bmcl.2015.06.079
None Unchecked Ki nan None 10.1016/j.bmcl.2015.10.074
None Unchecked Ratio Ki 1.2 None 10.1016/j.ejmech.2021.113956
None Unchecked Ratio Ki 7.2 None 10.1016/j.ejmech.2021.113956
None Unchecked Ratio Ki 9.3 None 10.1016/j.ejmech.2021.113956

Metabolism Information