Acivicin
AlkaPlorer ID: AK283121
Synonym: α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, 2-Amino-2-(3-chloro-4,5-dihydro-5-isoxazolyl)acetic acid, AT 125, NSC 163501, U 42126, Antibiotic AT 125, Antibiotic U 42126
IUPAC Name: 2-amino-2-(3-chloro-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
Structure
SMILES: NC(C(=O)O)C1CC(Cl)=NO1
InChI: InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)
InChIKey: QAWIHIJWNYOLBE-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sviceus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 178.575
TPSA？: 84.91000000000001
MolLogP？: -0.2604999999999999
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | DNA polymerase beta | Potency | 89125.1 | nM | None |
| Homo sapiens | Prelamin-A/C | Potency | 35481.3 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 3294.4 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 4653.5 | nM | None |
| None | Unchecked | EC50 | 175.0 | nM | None |