Acivicin; 4S-Hydroxy
AlkaPlorer ID: AK283122
Synonym: Antibiotic U 43795, U 43795
IUPAC Name: 2-amino-2-(3-chloro-4-hydroxy-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
Structure
SMILES: NC(C(=O)O)C1ON=C(Cl)C1O
InChI: InChI=1S/C5H7ClN2O4/c6-4-2(9)3(12-8-4)1(7)5(10)11/h1-3,9H,7H2,(H,10,11)
InChIKey: KUYDILDQEMQBKJ-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sviceus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 194.574
TPSA？: 105.14
MolLogP？: -1.2897
Number of H-Donors: 3
Number of H-Acceptors: 5
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Ataxin-2 | Potency | 751.9 | nM | None |
| Homo sapiens | Chromobox protein homolog 1 | Potency | 89125.1 | nM | None |
| Homo sapiens | DNA polymerase eta | Potency | 31622.8 | nM | None |
| Homo sapiens | Geminin | Potency | 23109.3 | nM | None |
| Homo sapiens | Glycoprotein hormones alpha chain | Potency | 15848.9 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 11220.2 | nM | None |
| Homo sapiens | Isocitrate dehydrogenase [NADP] cytoplasmic | Potency | 20596.2 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4A | Potency | 79432.8 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 7307.8 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 5804.8 | nM | None |
| None | Unchecked | Potency | 651.3 | nM | None |
| None | Unchecked | Potency | 10000.0 | nM | None |
| None | Unchecked | Potency | 25118.9 | nM | None |