2-Amino-2-(4-hydroxyphenyl)acetic acid; (±)-form
AlkaPlorer ID: AK285986
Synonym: None
IUPAC Name: 2-amino-2-(4-hydroxyphenyl)acetic acid
Structure
SMILES: NC(C(=O)O)C1=CC=C(O)C=C1
InChI: InChI=1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)
InChIKey: LJCWONGJFPCTTL-UHFFFAOYSA-N
Reference
The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus
PubChem CID: 92143
LOTUS: LTS0071625
COCONUT: CNP0106681.2
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Caesalpinia | Fabaceae | Fabales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
| None | Caesalpinia | Fabaceae | Fabales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 167.164
TPSA？: 83.55000000000001
MolLogP？: 0.4766
Number of H-Donors: 3
Number of H-Acceptors: 3
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Rattus norvegicus | Pyruvate dehydrogenase kinase | PDH active/PDH total | 26.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Pyruvate dehydrogenase kinase | PDH active/PDH total | 82.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Pyruvate dehydrogenase kinase | PDH active/PDH total | 87.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Pyruvate dehydrogenase kinase | Stimulation | -6.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Pyruvate dehydrogenase kinase | Stimulation | 172.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Rattus norvegicus | Stimulation | 26.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Rattus norvegicus | Stimulation | 84.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Rattus norvegicus | Stimulation | 123.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Rattus norvegicus | Stimulation | 130.0 | % | 10.1021/jm00136a009 |
| Rattus norvegicus | Rattus norvegicus | Stimulation | 136.0 | % | 10.1021/jm00136a009 |
| Severe acute respiratory syndrome coronavirus 2 | Replicase polyprotein 1ab | Inhibition | 12.58 | % | 10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | -18.91 | % | 10.21203/rs.3.rs-23951/v1 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | 0.28 | % | 10.6019/CHEMBL4495565 |