Anisomycin
AlkaPlorer ID: AK288029
Synonym: 2-(4-Methoxyphenylmethyl)-3,4-pyrrolidinediol 3-acetate, Flagecidin, PA 106, SA 3097C1, Antibiotic SA 3097C1, Antibiotic PA 106, Anhydroscopin A, NSC 76712
IUPAC Name: [4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate
Structure
SMILES: COC1=CC=C(CC2NCC(O)C2OC(C)=O)C=C1
InChI: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3
InChIKey: YKJYKKNCCRKFSL-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
| Streptomyces griseolus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 265.309
TPSA？: 67.78999999999999
MolLogP？: 0.5020999999999994
Number of H-Donors: 2
Number of H-Acceptors: 5
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Giardia | Giardia | Potency | 1029.7 | nM | None |
| Giardia | Giardia | Potency | 1468.9 | nM | None |
| Homo sapiens | Alpha-synuclein | Potency | 35481.3 | nM | None |
| Homo sapiens | Ataxin-2 | Potency | 376.9 | nM | None |
| Homo sapiens | Geminin | Potency | 5.8 | nM | None |
| Homo sapiens | Glucagon-like peptide 1 receptor | Potency | 1584.9 | nM | None |
| Homo sapiens | Glycoprotein hormones alpha chain | Potency | 316.2 | nM | None |
| Homo sapiens | Huh-7 | CC50 | 8110.0 | nM | 10.1073/pnas.0802982105 |
| Homo sapiens | Isocitrate dehydrogenase [NADP] cytoplasmic | Potency | 1835.6 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 82.0 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 103.2 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 112.2 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 461.1 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 1458.1 | nM | None |
| Homo sapiens | TAR DNA-binding protein 43 | Potency | 12589.3 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 16.4 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 53.1 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 75.0 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 206.0 | nM | None |
| Human immunodeficiency virus 1 | Aberrant vpr protein | Potency | 50118.7 | nM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 79.4 | nM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 1000.0 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | EC50 | 36.9 | nM | 10.1073/pnas.0802982105 |
| Plasmodium falciparum | Plasmodium falciparum | EC50 | 48.5 | nM | 10.1073/pnas.0802982105 |
| Pseudomonas aeruginosa | Beta Lactamase | IC50 | 49743.0 | nM | None |
| Rattus norvegicus | Thioredoxin reductase 1, cytoplasmic | Potency | 25118.9 | nM | None |
| None | Unchecked | AbsAC40_uM | 0.275 | uM | None |
| None | Unchecked | AC50 | 260.0 | nM | None |
| None | Unchecked | AC50 | 308.0 | nM | None |
| None | Unchecked | AC50 | 1090.0 | nM | None |
| None | Unchecked | IC50 | 49743.0 | nM | None |
| None | Unchecked | IFI | nan | % | 10.1073/pnas.0802982105 |
| None | Unchecked | Potency | 0.5 | nM | None |
| None | Unchecked | Potency | 8.9 | nM | None |
| None | Unchecked | Potency | 112.2 | nM | None |
| None | Unchecked | Potency | 130.0 | nM | None |
| None | Unchecked | Potency | 231.1 | nM | None |
| None | Unchecked | Potency | 366.3 | nM | None |
| None | Unchecked | Potency | 501.2 | nM | None |
| None | Unchecked | Potency | 562.3 | nM | None |
| None | Unchecked | Potency | 1000.0 | nM | None |
| None | Unchecked | Potency | 2818.4 | nM | None |
| None | Unchecked | Potency | 1412537.5 | nM | None |