Micranthine; Me ether
AlkaPlorer ID: AK288926
Synonym: O-Methylmicranthine
IUPAC Name: 13,27-dimethoxy-22-methyl-15,29,31-trioxa-7,22-diazaoctacyclo[19.9.3.216,19.14,30.110,14.03,8.025,33.028,32]heptatriaconta-1(30),2,4(34),10(37),11,13,16,18,25,27,32,35-dodecaene
Structure
SMILES: COC1=CC=C2C=C1OC1=CC=C(C=C1)CC1C3=C4OC5=C(C=C6CCNC(C2)C6=C5)OC4=C(OC)C=C3CCN1C
InChI: InChI=1S/C35H34N2O5/c1-37-13-11-23-18-32(39-3)34-35-33(23)27(37)15-20-4-7-24(8-5-20)40-29-16-21(6-9-28(29)38-2)14-26-25-19-31(42-35)30(41-34)17-22(25)10-12-36-26/h4-9,16-19,26-27,36H,10-15H2,1-3H3
InChIKey: DJAWTLHBPPQMPV-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Daphnandra micrantha | Daphnandra | Atherospermataceae | Laurales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 562.6660000000002
TPSA？: 61.42000000000001
MolLogP？: 6.908700000000006
Number of H-Donors: 1
Number of H-Acceptors: 7
RingCount: 9
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Potency | 89125.1 | nM | None |
| Homo sapiens | 786-0 | GI50 | 1786.49 | nM | None |
| Homo sapiens | A498 | GI50 | 2103.78 | nM | None |
| Homo sapiens | A549 | GI50 | 2202.93 | nM | None |
| Homo sapiens | ACHN | GI50 | 1883.65 | nM | None |
| Homo sapiens | Ataxin-2 | Potency | 8436.8 | nM | None |
| Homo sapiens | ATPase family AAA domain-containing protein 5 | Potency | 18348.9 | nM | None |
| Homo sapiens | Bromodomain adjacent to zinc finger domain protein 2B | Potency | 6309.6 | nM | None |
| Homo sapiens | BT-549 | GI50 | 2766.94 | nM | None |
| Homo sapiens | CAKI-1 | GI50 | 2870.78 | nM | None |
| Homo sapiens | CCRF-CEM | GI50 | 1244.51 | nM | None |
| Homo sapiens | Chromobox protein homolog 1 | Potency | 15848.9 | nM | None |
| Homo sapiens | COLO 205 | GI50 | 1717.91 | nM | None |
| Homo sapiens | DU-145 | GI50 | 1905.46 | nM | None |
| Homo sapiens | EKVX | GI50 | 1936.42 | nM | None |
| Homo sapiens | Flap endonuclease 1 | Potency | 3981.1 | nM | None |
| Homo sapiens | Geminin | Potency | 4610.9 | nM | None |
| Homo sapiens | Glucagon-like peptide 1 receptor | Potency | 5623.4 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 31622.8 | nM | None |
| Homo sapiens | HCC 2998 | GI50 | 1196.74 | nM | None |
| Homo sapiens | HCT-116 | GI50 | 1625.55 | nM | None |
| Homo sapiens | HCT-15 | GI50 | 1770.11 | nM | None |
| Homo sapiens | HepG2 | Potency | 1122.0 | nM | None |
| Homo sapiens | Histone acetyltransferase GCN5 | Potency | 794.3 | nM | None |
| Homo sapiens | Histone-lysine N-methyltransferase MLL | Potency | 63095.7 | nM | None |
| Homo sapiens | HL-60 | GI50 | 1840.77 | nM | None |
| Homo sapiens | HOP-62 | GI50 | 2202.93 | nM | None |
| Homo sapiens | HOP-92 | GI50 | 2454.71 | nM | None |
| Homo sapiens | Hs-578T | GI50 | 2192.8 | nM | None |
| Homo sapiens | HT-29 | GI50 | 1475.71 | nM | None |
| Homo sapiens | Huntingtin | Potency | 3981.1 | nM | None |
| Homo sapiens | IGROV-1 | GI50 | 1866.38 | nM | None |
| Homo sapiens | Isocitrate dehydrogenase [NADP] cytoplasmic | Potency | 20596.2 | nM | None |
| Homo sapiens | KM12 | GI50 | 1845.02 | nM | None |
| Homo sapiens | LOX IMVI | GI50 | 1694.34 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4A | Potency | 11220.2 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4D-like | Potency | 28183.8 | nM | None |
| Homo sapiens | M14 | GI50 | 2582.26 | nM | None |
| Homo sapiens | Malme-3M | GI50 | 2089.3 | nM | None |
| Homo sapiens | MAP kinase ERK2 | Potency | 39810.7 | nM | None |
| Homo sapiens | MCF7 | GI50 | 1845.02 | nM | None |
| Homo sapiens | MDA-MB-231 | GI50 | 2027.68 | nM | None |
| Homo sapiens | MDA-MB-435 | GI50 | 1798.87 | nM | None |
| Homo sapiens | MDA-N | GI50 | 1832.31 | nM | None |
| Homo sapiens | microRNA 21 | Potency | 26121.6 | nM | None |
| Homo sapiens | Microtubule-associated protein tau | Potency | 22387.2 | nM | None |
| Homo sapiens | MOLT-4 | GI50 | 1455.46 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 10000.0 | nM | None |
| Homo sapiens | Muscleblind-like protein 1 | Potency | 199526.2 | nM | None |
| Homo sapiens | NCI/ADR-RES | GI50 | 1918.67 | nM | None |
| Homo sapiens | NCI-H226 | GI50 | 5520.77 | nM | None |
| Homo sapiens | NCI-H23 | GI50 | 2060.63 | nM | None |
| Homo sapiens | NCI-H322M | GI50 | 1887.99 | nM | None |
| Homo sapiens | NCI-H460 | GI50 | 1757.92 | nM | None |
| Homo sapiens | NCI-H522 | GI50 | 1698.24 | nM | None |
| Homo sapiens | Neuropeptide S receptor | Potency | 12589.3 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 29092.9 | nM | None |
| Homo sapiens | OVCAR-3 | GI50 | 2691.53 | nM | None |
| Homo sapiens | OVCAR-4 | GI50 | 2333.46 | nM | None |
| Homo sapiens | OVCAR-5 | GI50 | 3597.49 | nM | None |
| Homo sapiens | OVCAR-8 | GI50 | 1766.04 | nM | None |
| Homo sapiens | PC-3 | GI50 | 1883.65 | nM | None |
| Homo sapiens | RPMI-8226 | GI50 | 1633.05 | nM | None |
| Homo sapiens | Runt-related transcription factor 1/Core-binding factor subunit beta | Potency | 5623.4 | nM | None |
| Homo sapiens | RXF 393 | GI50 | 1548.82 | nM | None |
| Homo sapiens | SF-268 | GI50 | 1954.34 | nM | None |
| Homo sapiens | SF-295 | GI50 | 1909.85 | nM | None |
| Homo sapiens | SF-539 | GI50 | 1698.24 | nM | None |
| Homo sapiens | SK-MEL-2 | GI50 | 1840.77 | nM | None |
| Homo sapiens | SK-MEL-28 | GI50 | 1883.65 | nM | None |
| Homo sapiens | SK-MEL-5 | GI50 | 2060.63 | nM | None |
| Homo sapiens | SK-OV-3 | GI50 | 4666.59 | nM | None |
| Homo sapiens | SN12C | GI50 | 1914.26 | nM | None |
| Homo sapiens | SNB-19 | GI50 | 2004.47 | nM | None |
| Homo sapiens | SR | GI50 | 698.23 | nM | None |
| Homo sapiens | SW-620 | GI50 | 1766.04 | nM | None |
| Homo sapiens | T47D | GI50 | 2070.14 | nM | None |
| Homo sapiens | TK-10 | GI50 | 1862.09 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 1636.0 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 2909.3 | nM | None |
| Homo sapiens | U-251 | GI50 | 1840.77 | nM | None |
| Homo sapiens | UACC-257 | GI50 | 1667.25 | nM | None |
| Homo sapiens | UACC-62 | GI50 | 1819.7 | nM | None |
| Homo sapiens | UO-31 | GI50 | 15631.48 | nM | None |
| Homo sapiens | Werner syndrome ATP-dependent helicase | Potency | 8912.5 | nM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 4466.8 | nM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 7079.5 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 329.4 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 522.1 | nM | None |
| None | Unchecked | EC50 | 193.0 | nM | None |
| None | Unchecked | EC50 | 6682.0 | nM | None |
| None | Unchecked | EC50 | 8025.0 | nM | None |
| None | Unchecked | EC50 | 8277.0 | nM | None |
| None | Unchecked | EC50 | 80000.0 | nM | None |
| None | Unchecked | EC50 | 120000.0 | nM | None |
| None | Unchecked | Potency | 11220.2 | nM | None |
| None | Unchecked | Potency | 12589.3 | nM | None |
| None | Unchecked | Potency | 14125.4 | nM | None |
| None | Unchecked | Potency | 17782.8 | nM | None |
| None | Unchecked | Potency | 18356.4 | nM | None |
| None | Unchecked | Potency | 19952.6 | nM | None |
| None | Unchecked | Potency | 29092.9 | nM | None |
| None | Unchecked | Potency | 39810.7 | nM | None |