2,3,10,11-Berbinetetrol; (S)-form, 3,10,11-Tri-Me ether
AlkaPlorer ID: AK290531
Synonym: Govanine, Corydalis L
IUPAC Name: 3,10,11-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol
Structure
SMILES: COC1=CC2=C(C=C1O)C1CC3=CC(OC)=C(OC)C=C3CN1CC2
InChI: InChI=1S/C20H23NO4/c1-23-18-7-12-4-5-21-11-14-9-20(25-3)19(24-2)8-13(14)6-16(21)15(12)10-17(18)22/h7-10,16,22H,4-6,11H2,1-3H3
InChIKey: YCBKBUUDECGKKX-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Corydalis govaniana | Corydalis | Papaveraceae | Ranunculales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 341.4070000000001
TPSA？: 51.16
MolLogP？: 3.073500000000002
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Dopamine D1 receptor | Activity | 24.38 | % | 10.1016/j.bmc.2019.04.014 |
| Homo sapiens | Dopamine D1 receptor | IC50 | 10000.0 | nM | 10.1016/j.bmc.2019.04.014 |
| Homo sapiens | Dopamine D2 receptor | Activity | 3.67 | % | 10.1016/j.bmc.2019.04.014 |
| Homo sapiens | Dopamine D2 receptor | IC50 | 3580.0 | nM | 10.1016/j.bmc.2019.04.014 |