Citreamicin δ
AlkaPlorer ID: AK292572
Synonym: None
IUPAC Name: 3,25-dihydroxy-7-(hydroxymethyl)-24-methoxy-7,10-dimethyl-9,20-dioxa-6-azaheptacyclo[15.12.0.02,14.04,12.06,10.019,28.021,26]nonacosa-1(17),2,4(12),13,15,19(28),21(26),22,24-nonaene-5,8,18,27,29-pentone
Structure
SMILES: COC1=C(O)C2=C(C=C1)OC1=C(C(=O)C3=C(C=CC4=CC5=C(C(=O)N6C(C)(C5)OC(=O)C6(C)CO)C(O)=C34)C1=O)C2=O
InChI: InChI=1S/C30H21NO11/c1-29(10-32)28(39)42-30(2)9-12-8-11-4-5-13-18(16(11)23(35)17(12)27(38)31(29)30)24(36)20-25(37)19-14(41-26(20)21(13)33)6-7-15(40-3)22(19)34/h4-8,32,34-35H,9-10H2,1-3H3
InChIKey: YDSUTHJTPFUHBP-UHFFFAOYSA-N
Reference
Citreamicins with Potent Gram-Positive Activity
PubChem CID: 25147605
LOTUS: LTS0255057
NPASS: NPC316292
COCONUT: CNP0199113.1
{NPAtlas: NPA012149
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces vinaceus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 571.4940000000003
TPSA？: 180.88
MolLogP？: 2.1637000000000013
Number of H-Donors: 3
Number of H-Acceptors: 11
RingCount: 7
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Enterococcus faecium | Enterococcus faecium | MIC | 0.25 | ug.mL-1 | 10.1021/np800503z |
| Escherichia coli | Escherichia coli | MIC | 64.0 | ug.mL-1 | 10.1021/np800503z |
| Escherichia coli | Escherichia coli | MIC | 128.0 | ug.mL-1 | 10.1021/np800503z |
| Haemophilus influenzae | Haemophilus influenzae | MIC | 1.0 | ug.mL-1 | 10.1021/np800503z |
| Haemophilus parainfluenzae | Haemophilus parainfluenzae | MIC | 1.0 | ug.mL-1 | 10.1021/np800503z |
| Homo sapiens | NHDF | CC90 | 0.3 | ug ml-1 | 10.1021/np800503z |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC | 64.0 | ug.mL-1 | 10.1021/np800503z |
| Moraxella catarrhalis | Moraxella catarrhalis | MIC | 4.0 | ug.mL-1 | 10.1021/np800503z |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 64.0 | ug.mL-1 | 10.1021/np800503z |
| Serratia marcescens | Serratia marcescens | MIC | 64.0 | ug.mL-1 | 10.1021/np800503z |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 0.5 | ug.mL-1 | 10.1021/np800503z |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 1.0 | ug.mL-1 | 10.1021/np800503z |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 2.0 | ug.mL-1 | 10.1021/np800503z |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC | 0.06 | ug.mL-1 | 10.1021/np800503z |
| None | NON-PROTEIN TARGET | CC90 | 2.4 | ug ml-1 | 10.1021/np800503z |