5,7-Dihydroxy-8-(2-piperidinyl)flavone; 5-Me ether
AlkaPlorer ID: AK296441
Synonym: N-Demethylbuchenavianine
IUPAC Name: 7-hydroxy-5-methoxy-2-phenyl-8-piperidin-2-ylchromen-4-one
Structure
SMILES: COC1=CC(O)=C(C2CCCCN2)C2=C1C(=O)C=C(C1=CC=CC=C1)O2
InChI: InChI=1S/C21H21NO4/c1-25-18-12-15(23)19(14-9-5-6-10-22-14)21-20(18)16(24)11-17(26-21)13-7-3-2-4-8-13/h2-4,7-8,11-12,14,22-23H,5-6,9-10H2,1H3
InChIKey: NCKUKESTUWVGFY-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Buchenavia | Combretaceae | Myrtales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 351.40200000000004
TPSA？: 71.7
MolLogP？: 3.988800000000002
Number of H-Donors: 2
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Cyclin-dependent kinase 5/CDK5 activator 1 | IC50 | 10000.0 | nM | 10.1021/jm201727w |
| Mus musculus | Dual specificity protein kinase CLK1 | IC50 | 10000.0 | nM | 10.1021/jm201727w |
| Rattus norvegicus | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | 10000.0 | nM | 10.1021/jm201727w |
| Sus scrofa | Glycogen synthase kinase-3 | IC50 | 10000.0 | nM | 10.1021/jm201727w |
| None | Unchecked | IC50 | 10000.0 | nM | 10.1021/jm201727w |