Molecule

Elaiomycin B; N-Dealkyl, N-(1Z-tetradecenyl)

AlkaPlorer ID: AK297346

Synonym: Hydrazidomycin A

IUPAC Name: N'-(2-methoxyacetyl)-N-[(Z)-tetradec-1-enyl]decanehydrazide

Structure

SMILES: CCCCCCCCCCCC/C=C\N(N=C(O)COC)C(=O)CCCCCCCCC

InChI: InChI=1S/C27H52N2O3/c1-4-6-8-10-12-13-14-15-16-18-20-22-24-29(28-26(30)25-32-3)27(31)23-21-19-17-11-9-7-5-2/h22,24H,4-21,23,25H2,1-3H3,(H,28,30)/b24-22-

InChIKey: HZOWHYHEDAUGGZ-GYHWCHFESA-N

Reference

Hydrazidomycins, cytotoxic alkylhydrazides from Streptomyces atratus

PubChem CID: 53483940

CAS: 1342298-81-0

LOTUS: LTS0133054

NPASS: NPC163537

{

NPAtlas: NPA018775

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Streptomyces atratus	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 452.7240000000005

TPSA？: 62.13

MolLogP？: 8.298300000000008

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 0

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	CAL-27	IC50	716.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	CWR22R	IC50	882.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	DU-145	IC50	539.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	HCT-116	IC50	758.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	HeLa	CC50	108200.0	nM	10.1016/j.bmcl.2013.09.033
Homo sapiens	HT-29	GI50	460.0	nM	10.1016/j.bmcl.2013.09.033
Homo sapiens	HT-29	IC50	464.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	HUVEC	GI50	70700.0	nM	10.1016/j.bmcl.2013.09.033
Homo sapiens	K562	GI50	110400.0	nM	10.1016/j.bmcl.2013.09.033
Homo sapiens	LNCaP	IC50	957.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	MCF7	IC50	782.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	MDA-MB-231	IC50	286.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	MKN-45	IC50	676.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	NCI-H460	IC50	2310.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	PANC-1	IC50	933.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	RKO	IC50	598.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	SAOS-2	IC50	1820.0	nM	10.1016/j.bmcl.2011.07.108
Homo sapiens	TE-671	IC50	898.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	105.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	144.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	222.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	247.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	349.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	471.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	660.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	765.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	782.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	893.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	936.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	982.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1100.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1110.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1190.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1340.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1590.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1620.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1650.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	1910.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	2120.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	2300.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	2310.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	2400.0	nM	10.1016/j.bmcl.2011.07.108
None	NON-PROTEIN TARGET	IC50	2430.0	nM	10.1016/j.bmcl.2011.07.108