Harmicine; (±)-form
AlkaPlorer ID: AK300016
Synonym: None
IUPAC Name: 2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole
Structure
SMILES: C1=CC=C2C3=C(NC2=C1)C1CCCN1CC3
InChI: InChI=1S/C14H16N2/c1-2-5-12-10(4-1)11-7-9-16-8-3-6-13(16)14(11)15-12/h1-2,4-5,13,15H,3,6-9H2
InChIKey: LXJWBHIVLXMHDZ-UHFFFAOYSA-N
Reference
Alkaloids from Kopsia griffithii
PubChem CID: 372331
CAS: 202258-15-9
LOTUS: LTS0204278
COCONUT: CNP0296431.1
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Kopsia griffithii | Kopsia | Apocynaceae | Gentianales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 212.2959999999999
TPSA？: 19.03
MolLogP？: 2.860900000000001
Number of H-Donors: 1
Number of H-Acceptors: 1
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 786-0 | GI50 | 10000.0 | nM | None |
| Homo sapiens | A498 | GI50 | 10000.0 | nM | None |
| Homo sapiens | ACHN | GI50 | 10000.0 | nM | None |
| Homo sapiens | CAKI-1 | GI50 | 10000.0 | nM | None |
| Homo sapiens | CCRF-CEM | GI50 | 10000.0 | nM | None |
| Homo sapiens | COLO 205 | GI50 | 10000.0 | nM | None |
| Homo sapiens | DU-145 | GI50 | 10000.0 | nM | None |
| Homo sapiens | EKVX | GI50 | 10000.0 | nM | None |
| Homo sapiens | HCC 2998 | GI50 | 10000.0 | nM | None |
| Homo sapiens | HCT-15 | GI50 | 10000.0 | nM | None |
| Homo sapiens | HL-60 | GI50 | 10000.0 | nM | None |
| Homo sapiens | HOP-62 | GI50 | 10000.0 | nM | None |
| Homo sapiens | HOP-92 | GI50 | 10000.0 | nM | None |
| Homo sapiens | Hs-578T | GI50 | 10000.0 | nM | None |
| Homo sapiens | HT-29 | GI50 | 10000.0 | nM | None |
| Homo sapiens | IGROV-1 | GI50 | 10000.0 | nM | None |
| Homo sapiens | K562 | GI50 | 10000.0 | nM | None |
| Homo sapiens | KM12 | GI50 | 10000.0 | nM | None |
| Homo sapiens | LOX IMVI | GI50 | 10000.0 | nM | None |
| Homo sapiens | M14 | GI50 | 10000.0 | nM | None |
| Homo sapiens | Malme-3M | GI50 | 10000.0 | nM | None |
| Homo sapiens | MCF7 | GI50 | 10000.0 | nM | None |
| Homo sapiens | MDA-MB-231 | GI50 | 10000.0 | nM | None |
| Homo sapiens | MDA-MB-435 | GI50 | 10000.0 | nM | None |
| Homo sapiens | MDA-N | GI50 | 10000.0 | nM | None |
| Homo sapiens | MOLT-4 | GI50 | 10000.0 | nM | None |
| Homo sapiens | NCI/ADR-RES | GI50 | 10000.0 | nM | None |
| Homo sapiens | NCI-H226 | GI50 | 10000.0 | nM | None |
| Homo sapiens | NCI-H23 | GI50 | 10000.0 | nM | None |
| Homo sapiens | NCI-H322M | GI50 | 10000.0 | nM | None |
| Homo sapiens | NCI-H460 | GI50 | 10000.0 | nM | None |
| Homo sapiens | NCI-H522 | GI50 | 10000.0 | nM | None |
| Homo sapiens | Neuronal acetylcholine receptor; alpha4/beta2 | Activity | nan | None | 10.1016/j.bmc.2011.08.028 |
| Homo sapiens | Neuronal acetylcholine receptor protein alpha-7 subunit | Ki | 31622.78 | nM | 10.1016/j.bmc.2011.08.028 |
| Homo sapiens | OVCAR-3 | GI50 | 10000.0 | nM | None |
| Homo sapiens | OVCAR-4 | GI50 | 10000.0 | nM | None |
| Homo sapiens | OVCAR-5 | GI50 | 10000.0 | nM | None |
| Homo sapiens | OVCAR-8 | GI50 | 10000.0 | nM | None |
| Homo sapiens | PC-3 | GI50 | 10000.0 | nM | None |
| Homo sapiens | RPMI-8226 | GI50 | 10000.0 | nM | None |
| Homo sapiens | RXF 393 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SF-268 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SF-295 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SF-539 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SK-MEL-2 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SK-MEL-28 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SK-MEL-5 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SK-OV-3 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SN12C | GI50 | 10000.0 | nM | None |
| Homo sapiens | SNB-19 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SNB-75 | GI50 | 10000.0 | nM | None |
| Homo sapiens | SR | GI50 | 10000.0 | nM | None |
| Homo sapiens | SW-620 | GI50 | 10000.0 | nM | None |
| Homo sapiens | T47D | GI50 | 10000.0 | nM | None |
| Homo sapiens | TK-10 | GI50 | 10000.0 | nM | None |
| Homo sapiens | U-251 | GI50 | 10000.0 | nM | None |
| Homo sapiens | UACC-257 | GI50 | 10000.0 | nM | None |
| Homo sapiens | UO-31 | GI50 | 10000.0 | nM | None |
| Lymnaea stagnalis | Acetylcholine-binding protein | Ki | 1258.93 | nM | 10.1016/j.bmc.2011.08.028 |