Nandigerine; (S)-form, N-Me
AlkaPlorer ID: AK307336
Synonym: N-Methylnandigerine, 10-Hydroxy-11-methoxy-1,2-methylenedioxyaporphine, N-Methylhernangerine, Isobulbocapnine
IUPAC Name: 18-methoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-17-ol
Structure
SMILES: COC1=C(O)C=CC2=C1C1=C3C(=CC4=C1OCO4)CCN(C)C3C2
InChI: InChI=1S/C19H19NO4/c1-20-6-5-11-8-14-19(24-9-23-14)17-15(11)12(20)7-10-3-4-13(21)18(22-2)16(10)17/h3-4,8,12,21H,5-7,9H2,1-2H3
InChIKey: WOIZHRXESCUSGM-UHFFFAOYSA-N
Reference
Northalifoline, a New Isoquinolone Alkaloid from the Pedicels of Lindera megaphylla
PubChem CID: 3083908
CAS: 5544-68-3
LOTUS: LTS0274525
NPASS: NPC320223
COCONUT: CNP0217124.2
Source
Properties Information
Molecule Weight: 325.36400000000003
TPSA？: 51.16
MolLogP？: 2.881600000000001
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Potency | 31622.8 | nM | None |
| Homo sapiens | DNA polymerase iota | Potency | 79432.8 | nM | None |
| Homo sapiens | Glucagon-like peptide 1 receptor | Potency | 316.2 | nM | None |
| Homo sapiens | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Potency | 39810.7 | nM | None |
| Homo sapiens | Importin subunit beta-1/Snurportin-1 | Potency | 112201.8 | nM | None |
| Homo sapiens | Isocitrate dehydrogenase [NADP] cytoplasmic | Potency | 32642.7 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4D-like | Potency | 35481.3 | nM | None |
| Homo sapiens | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Potency | 35481.3 | nM | None |
| Homo sapiens | Prelamin-A/C | Potency | 12589.3 | nM | None |
| Homo sapiens | Rap guanine nucleotide exchange factor 3 | Potency | 5623.4 | nM | None |