Narciclasine
AlkaPlorer ID: AK307412
Synonym: Lycoricidinol
IUPAC Name: 2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one
Structure
SMILES: OC1=NC2C(=CC(O)C(O)C2O)C2=CC3=C(OCO3)C(O)=C12
InChI: InChI=1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)
InChIKey: LZAZURSABQIKGB-UHFFFAOYSA-N
Reference
Antifeedants for the larvae of the yellow butterfly, Eurema hecabe mandarina, in Lycoris radiata.
PubChem CID: 619061
CAS: 29477-83-6
LOTUS: LTS0062582
COCONUT: CNP0240588.10
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 307.25800000000004
TPSA？: 131.97000000000003
MolLogP？: -0.7126000000000003
Number of H-Donors: 5
Number of H-Acceptors: 7
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Caenorhabditis elegans | Protein skinhead-1 | IC50 | 24000.0 | nM | None |
| Caenorhabditis elegans | Protein skinhead-1 | IC50 | 51400.0 | nM | None |
| Homo sapiens | Alpha-synuclein | Potency | 17782.8 | nM | None |
| Homo sapiens | Ataxin-2 | Potency | 158.5 | nM | None |
| Homo sapiens | Geminin | Potency | 10322.5 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 2238.7 | nM | None |
| Homo sapiens | HEK293 | Potency | 100.0 | nM | None |
| Homo sapiens | Isocitrate dehydrogenase [NADP] cytoplasmic | Potency | 730.8 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 18.4 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 73.1 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 259.3 | nM | None |
| Homo sapiens | Regulator of G-protein signaling 4 | Potency | 100000.0 | nM | None |
| Homo sapiens | Sphingomyelin phosphodiesterase | Potency | 25118.9 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 58.0 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 92.0 | nM | None |
| Pseudomonas aeruginosa | Beta Lactamase | IC50 | 49732.0 | nM | None |
| None | NON-PROTEIN TARGET | AC50 | 167.0 | nM | None |
| None | NON-PROTEIN TARGET | AC50 | 170.0 | nM | None |
| None | NON-PROTEIN TARGET | AC50 | 218.0 | nM | None |
| None | Unchecked | AC50 | 138.0 | nM | None |
| None | Unchecked | AC50 | 161.0 | nM | None |
| None | Unchecked | AC50 | 260.0 | nM | None |
| None | Unchecked | AC50 | 431.0 | nM | None |
| None | Unchecked | AC50 | 58950.0 | nM | None |
| None | Unchecked | IC50 | 49732.0 | nM | None |
| None | Unchecked | Potency | 58.0 | nM | None |
| None | Unchecked | Potency | 100.0 | nM | None |
| None | Unchecked | Potency | 145.8 | nM | None |
| None | Unchecked | Potency | 251.2 | nM | None |
| None | Unchecked | Potency | 259.3 | nM | None |
| None | Unchecked | Potency | 461.1 | nM | None |
| None | Unchecked | Potency | 8912.5 | nM | None |