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name Structure Reference Source Properties Activities Metabolism

Narciclasine; 7-Deoxy

AlkaPlorer ID: AK307413

Synonym: Lycoricidine, 7-Deoxynarciclasine, Margetine

IUPAC Name: 2,3,4-trihydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

Structure

SMILES: OC1=NC2C(=CC(O)C(O)C2O)C2=CC3=C(C=C12)OCO3

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InChI: InChI=1S/C14H13NO6/c16-8-1-6-5-2-9-10(21-4-20-9)3-7(5)14(19)15-11(6)13(18)12(8)17/h1-3,8,11-13,16-18H,4H2,(H,15,19)

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InChIKey: YYDLFVZOIDOGSO-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Lycoris radiata Lycoris Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 291.25900000000007

TPSA？: 111.74000000000002

MolLogP？: -0.4182000000000001

Number of H-Donors: 4

Number of H-Acceptors: 6

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Potency 31622.8 nM None
Caenorhabditis elegans Protein skinhead-1 IC50 64300.0 nM None
Caenorhabditis elegans Protein skinhead-1 IC50 100000.0 nM None
Homo sapiens 786-0 GI50 244.91 nM None
Homo sapiens A498 GI50 758.58 nM None
Homo sapiens A549 GI50 520.0 nM None
Homo sapiens ACHN GI50 143.55 nM None
Homo sapiens Ataxin-2 Potency 53.2 nM None
Homo sapiens CAKI-1 GI50 279.9 nM None
Homo sapiens CCRF-CEM GI50 205.59 nM None
Homo sapiens COLO 205 GI50 199.99 nM None
Homo sapiens DLD-1 GI50 254.68 nM None
Homo sapiens DMS-114 GI50 429.54 nM None
Homo sapiens DMS-273 GI50 435.51 nM None
Homo sapiens DNA polymerase eta Potency 31622.8 nM None
Homo sapiens DNA polymerase iota Potency 89125.1 nM None
Homo sapiens DU-145 GI50 55.98 nM None
Homo sapiens EKVX GI50 412.1 nM None
Homo sapiens Geminin Potency 730.8 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 1122.0 nM None
Homo sapiens HCC 2998 GI50 414.95 nM None
Homo sapiens HCT-116 GI50 150.31 nM None
Homo sapiens HCT-15 GI50 520.0 nM None
Homo sapiens HEK293 Potency 1000.0 nM None
Homo sapiens HepG2 Potency 223.9 nM None
Homo sapiens HL-60 GI50 108.14 nM None
Homo sapiens HOP-18 GI50 1475.71 nM None
Homo sapiens HOP-62 GI50 463.45 nM None
Homo sapiens HOP-92 GI50 903.65 nM None
Homo sapiens Hs-578T GI50 79.43 nM None
Homo sapiens HT-29 GI50 345.14 nM None
Homo sapiens IGROV-1 GI50 494.31 nM None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 1458.1 nM None
Homo sapiens K562 GI50 339.63 nM None
Homo sapiens KM12 GI50 272.27 nM None
Homo sapiens KM-20L2 GI50 304.79 nM None
Homo sapiens LOX IMVI GI50 308.32 nM None
Homo sapiens LXFL 529 GI50 429.54 nM None
Homo sapiens M14 GI50 243.78 nM None
Homo sapiens M19-MEL GI50 251.19 nM None
Homo sapiens Malme-3M GI50 487.53 nM None
Homo sapiens MCF7 GI50 338.06 nM None
Homo sapiens MDA-MB-231 GI50 48.64 nM None
Homo sapiens MDA-MB-435 GI50 95.06 nM None
Homo sapiens MDA-N GI50 83.18 nM None
Homo sapiens MOLT-4 GI50 109.14 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 354.8 nM None
Homo sapiens NCI/ADR-RES GI50 620.87 nM None
Homo sapiens NCI-H226 GI50 503.5 nM None
Homo sapiens NCI-H23 GI50 459.2 nM None
Homo sapiens NCI-H322M GI50 429.54 nM None
Homo sapiens NCI-H460 GI50 194.09 nM None
Homo sapiens NCI-H522 GI50 244.34 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 2059.6 nM None
Homo sapiens OVCAR-3 GI50 372.39 nM None
Homo sapiens OVCAR-4 GI50 338.06 nM None
Homo sapiens OVCAR-5 GI50 939.72 nM None
Homo sapiens OVCAR-8 GI50 232.81 nM None
Homo sapiens Paired box protein Pax-8 AC50 325.0 nM None
Homo sapiens PC-3 GI50 140.93 nM None
Homo sapiens RPMI-8226 GI50 414.0 nM None
Homo sapiens RXF 393 GI50 154.17 nM None
Homo sapiens RXF 631 GI50 432.51 nM None
Homo sapiens SF-268 GI50 171.4 nM None
Homo sapiens SF-295 GI50 582.1 nM None
Homo sapiens SF-539 GI50 458.14 nM None
Homo sapiens SK-MEL-2 GI50 350.75 nM None
Homo sapiens SK-MEL-28 GI50 416.87 nM None
Homo sapiens SK-MEL-5 GI50 164.06 nM None
Homo sapiens SK-OV-3 GI50 619.44 nM None
Homo sapiens SN12C GI50 301.3 nM None
Homo sapiens SN12K1 GI50 233.88 nM None
Homo sapiens SNB-19 GI50 243.78 nM None
Homo sapiens SNB-75 GI50 567.54 nM None
Homo sapiens SNB-78 GI50 568.85 nM None
Homo sapiens SR GI50 109.4 nM None
Homo sapiens SW-620 GI50 334.97 nM None
Homo sapiens T47D GI50 96.38 nM None
Homo sapiens TK-10 GI50 417.83 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 290.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 410.9 nM None
Homo sapiens U-251 GI50 218.27 nM None
Homo sapiens UACC-257 GI50 695.02 nM None
Homo sapiens UACC-62 GI50 420.73 nM None
Homo sapiens UO-31 GI50 563.64 nM None
Homo sapiens XF498 GI50 171.4 nM None
Mus musculus P388 GI50 115.35 nM None
Mus musculus P388/ADR GI50 98.4 nM None
None NON-PROTEIN TARGET AC50 738.0 nM None
None No relevant target AC50 3780.0 nM None
None Unchecked AbsAC35 0.429 uM None
None Unchecked AbsAC35_uM 0.837 uM None
None Unchecked AC50 2220.0 nM None
None Unchecked AC50 2380.0 nM None
None Unchecked AC50 3820.0 nM None
None Unchecked AC50 53860.0 nM None
None Unchecked Max_Activity 26.0 uM None
None Unchecked Potency 354.8 nM None
None Unchecked Potency 562.3 nM None
None Unchecked Potency 794.3 nM None
None Unchecked Potency 1000.0 nM None
None Unchecked Potency 1122.0 nM None
None Unchecked Potency 1158.2 nM None
None Unchecked Potency 3662.6 nM None

Metabolism Information