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Piperchabamide C

AlkaPlorer ID: AK310495

Synonym: 1-[13-(1,3-Benzodioxol-5-yl)-1-oxo-2,4,12-tridecatrienyl]piperidine, 13-(3,4-Methylenedioxyphenyl)-2,4,12-tridecatrienoic acid piperidide

IUPAC Name: (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-1-piperidin-1-yltrideca-2,4,12-trien-1-one

Structure

SMILES: O=C(/C=C/C=C/CCCCCC/C=C/C1=CC=C2OCOC2=C1)N1CCCCC1

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InChI: InChI=1S/C25H33NO3/c27-25(26-18-12-9-13-19-26)15-11-8-6-4-2-1-3-5-7-10-14-22-16-17-23-24(20-22)29-21-28-23/h6,8,10-11,14-17,20H,1-5,7,9,12-13,18-19,21H2/b8-6+,14-10+,15-11+

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InChIKey: AVGVCMDFODSDCK-ODWZBEOQSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 395.5430000000003

TPSA？: 38.77

MolLogP？: 5.894000000000006

Number of H-Donors: 0

Number of H-Acceptors: 3

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Mus musculus 3T3-L1 Activity -11.0 % 10.1016/j.bmcl.2008.04.052
Mus musculus 3T3-L1 Activity -10.2 % 10.1016/j.bmcl.2008.04.052
Mus musculus 3T3-L1 Activity 9.4 % 10.1016/j.bmcl.2008.04.052
Mus musculus 3T3-L1 Activity 17.6 % 10.1016/j.bmcl.2008.04.052
Mus musculus Hepatocyte IC50 6700.0 nM 10.1016/j.bmc.2009.08.050
Mus musculus Hepatocyte Inhibition 42.0 % 10.1016/j.bmc.2009.08.050
Mus musculus Hepatocyte Inhibition 42.0 % 10.1016/j.bmcl.2008.01.101
Mus musculus Hepatocyte Inhibition 52.0 % 10.1016/j.bmc.2009.08.050
Mus musculus Hepatocyte Inhibition 52.0 % 10.1016/j.bmcl.2008.01.101
Mus musculus Hepatocyte Inhibition 68.0 % 10.1016/j.bmc.2009.08.050
Mus musculus Hepatocyte Inhibition 68.0 % 10.1016/j.bmcl.2008.01.101
Mus musculus L929 IC50 42000.0 nM 10.1016/j.bmc.2009.08.050
Mus musculus L929 Inhibition 2.0 % 10.1016/j.bmc.2009.08.050
Mus musculus L929 Inhibition 25.0 % 10.1016/j.bmc.2009.08.050
Mus musculus L929 Inhibition 92.0 % 10.1016/j.bmc.2009.08.050
None Peritoneal macrophage cell IC50 42000.0 nM 10.1016/j.bmc.2009.08.050
None Peritoneal macrophage cell Inhibition 9.0 % 10.1016/j.bmc.2009.08.050
None Peritoneal macrophage cell Inhibition 10.0 % 10.1016/j.bmc.2009.08.050
None Peritoneal macrophage cell Inhibition 23.0 % 10.1016/j.bmc.2009.08.050
None Peritoneal macrophage cell Inhibition 86.0 % 10.1016/j.bmc.2009.08.050

Metabolism Information