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Staurosporine

AlkaPlorer ID: AK314249

Synonym: AM 2282, CGP 39360, M 193, Antibiotic 230, Antibiotic AM 2282, Antibiotic CGP 39360, Antibiotic M 193

IUPAC Name: 3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one

Structure

SMILES: CNC1CC2OC(C)(C1OC)N1C3=CC=CC=C3C3=C4CN=C(O)C4=C4C5=CC=CC=C5N2C4=C31

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InChI: InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)

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InChIKey: HKSZLNNOFSGOKW-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 466.5410000000003

TPSA？: 72.94

MolLogP？: 4.928800000000004

Number of H-Donors: 2

Number of H-Acceptors: 6

RingCount: 8

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Ki 1.259 nM None
Homo sapiens Activin receptor type-1 Ki 63.1 nM None
Homo sapiens ALK tyrosine kinase receptor Ki 5.012 nM None
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 0.3162 nM None
Homo sapiens CaM kinase I alpha Ki 12.59 nM None
Homo sapiens CaM kinase I delta Ki 3.981 nM None
Homo sapiens CaM kinase II alpha Ki 3.162 nM None
Homo sapiens CaM-kinase kinase beta Ki 0.1995 nM None
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 0.7943 nM None
Homo sapiens Casein kinase I alpha Ki 1258.93 nM None
Homo sapiens Casein kinase I delta Ki 2511.89 nM None
Homo sapiens Casein kinase II alpha Ki 1584.89 nM None
Homo sapiens Cell division protein kinase 8 Ki 19.95 nM None
Homo sapiens c-Jun N-terminal kinase 1 Ki 100.0 nM None
Homo sapiens c-Jun N-terminal kinase 2 Ki 1995.26 nM None
Homo sapiens c-Jun N-terminal kinase 3 Ki 50.12 nM None
Homo sapiens Cyclin-dependent kinase 1 Ki 3.981 nM None
Homo sapiens Cyclin-dependent kinase 5 Ki 3.981 nM None
Homo sapiens Cyclin-dependent kinase 7 Ki 63.1 nM None
Homo sapiens Cyclin-dependent kinase 9 Ki 12.59 nM None
Homo sapiens Death-associated protein kinase 3 Ki 1.995 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Ki 6.31 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Ki 630.96 nM None
Homo sapiens Dual specificity protein kinase CLK2 Ki 19.95 nM None
Homo sapiens Dual specificity protein kinase CLK4 Ki 1.995 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 2.512 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Ki 5.012 nM None
Homo sapiens Ephrin type-A receptor 2 Ki 251.19 nM None
Homo sapiens Epidermal growth factor receptor erbB1 Ki 25.12 nM None
Homo sapiens Fibroblast growth factor receptor 1 Ki 39.81 nM None
Homo sapiens Fibroblast growth factor receptor 3 Ki 39.81 nM None
Homo sapiens Focal adhesion kinase 1 Ki 100.0 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Ki 15.85 nM None
Homo sapiens Glycogen synthase kinase-3 beta Ki 31.62 nM None
Homo sapiens G protein-coupled receptor kinase 5 Ki 25.12 nM None
Homo sapiens Hepatocyte growth factor receptor IC50 107.4 nM None
Homo sapiens Hepatocyte growth factor receptor Ki 100.0 nM None
Homo sapiens Homeodomain-interacting protein kinase 2 Ki 125.89 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Ki 50.12 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Ki 251.19 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Ki 5.012 nM None
Homo sapiens Insulin-like growth factor I receptor IC50 71.53 nM None
Homo sapiens Insulin-like growth factor I receptor Ki 25.12 nM None
Homo sapiens Insulin receptor IC50 36.35 nM None
Homo sapiens Insulin receptor Ki 12.59 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 4 Ki 10.0 nM None
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Ki 0.3981 nM None
Homo sapiens Leukocyte tyrosine kinase receptor Ki 3.162 nM None
Homo sapiens LIM domain kinase 1 Ki 100.0 nM None
Homo sapiens Macrophage colony stimulating factor receptor Ki 7.943 nM None
Homo sapiens Macrophage-stimulating protein receptor Ki 0.2512 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Ki 79.43 nM None
Homo sapiens MAP kinase-activated protein kinase 3 Ki 3981.07 nM None
Homo sapiens MAP kinase ERK2 Ki 501.19 nM None
Homo sapiens MAP kinase p38 alpha Ki 3981.07 nM None
Homo sapiens MAP kinase p38 delta Ki 199.53 nM None
Homo sapiens MAP kinase p38 gamma Ki 199.53 nM None
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Ki 7.943 nM None
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Ki 0.7943 nM None
Homo sapiens Maternal embryonic leucine zipper kinase Ki 0.3162 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Ki 3.162 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Ki 5.012 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 1.585 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Ki 0.631 nM None
Homo sapiens Nerve growth factor receptor Trk-A IC50 1.405 nM None
Homo sapiens Nerve growth factor receptor Trk-A Ki 6.31 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 IC50 1.182 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 0.7943 nM None
Homo sapiens NT-3 growth factor receptor IC50 0.525 nM None
Homo sapiens NT-3 growth factor receptor Ki 1.995 nM None
Homo sapiens Platelet-derived growth factor receptor alpha Ki 7.943 nM None
Homo sapiens Platelet-derived growth factor receptor beta Ki 0.7943 nM None
Homo sapiens Protein kinase C delta Ki 3.162 nM None
Homo sapiens Protein kinase C gamma Ki 3.162 nM None
Homo sapiens Protein kinase C nu Ki 39.81 nM None
Homo sapiens Protein kinase C theta Ki 1.995 nM None
Homo sapiens Protein kinase C zeta Ki 50.12 nM None
Homo sapiens Protein kinase N2 Ki 0.7943 nM None
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS IC50 0.248 nM None
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Ki 0.5012 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki 31.62 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Ki 251.19 nM None
Homo sapiens Rho-associated protein kinase 1 Ki 0.7943 nM None
Homo sapiens Rho-associated protein kinase 2 Ki 0.5012 nM None
Homo sapiens Ribosomal protein S6 kinase 1 Ki 5.012 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 1.585 nM None
Homo sapiens Serine/threonine-protein kinase 17A Ki 2.512 nM None
Homo sapiens Serine/threonine-protein kinase AKT Ki 2.512 nM None
Homo sapiens Serine/threonine-protein kinase AKT2 Ki 10.0 nM None
Homo sapiens Serine/threonine-protein kinase AKT3 Ki 6.31 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-A Ki 2.512 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Ki 1.995 nM None
Homo sapiens Serine/threonine-protein kinase Chk1 Ki 2.512 nM None
Homo sapiens Serine/threonine-protein kinase Chk2 Ki 10.0 nM None
Homo sapiens Serine/threonine-protein kinase c-TAK1 Ki 0.3981 nM None
Homo sapiens Serine/threonine-protein kinase D2 Ki 2.512 nM None
Homo sapiens Serine/threonine-protein kinase EEF2K Ki 1000.0 nM None
Homo sapiens Serine/threonine-protein kinase MRCK-A Ki 3.981 nM None
Homo sapiens Serine/threonine-protein kinase MST2 Ki 0.3981 nM None
Homo sapiens Serine/threonine-protein kinase NEK2 Ki 2511.89 nM None
Homo sapiens Serine/threonine-protein kinase PAK 1 Ki 5.012 nM None
Homo sapiens Serine/threonine-protein kinase PAK 4 Ki 7.943 nM None
Homo sapiens Serine/threonine-protein kinase PIM1 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase PIM2 Ki 3.162 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Ki 1258.93 nM None
Homo sapiens Serine/threonine-protein kinase PLK3 Ki 1995.26 nM None
Homo sapiens Serine/threonine-protein kinase PLK4 Ki 7.943 nM None
Homo sapiens Serine/threonine-protein kinase PRKX Ki 0.3162 nM None
Homo sapiens Serine/threonine-protein kinase receptor R3 IC50 1.361 nM None
Homo sapiens Serine/threonine-protein kinase Sgk2 Ki 7.943 nM None
Homo sapiens Serine/threonine-protein kinase SIK2 Ki 0.631 nM None
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 10.0 nM None
Homo sapiens Serine/threonine-protein kinase TBK1 Ki 1.259 nM None
Homo sapiens Serine/threonine-protein kinase WEE1 Ki 1995.26 nM None
Homo sapiens Stem cell growth factor receptor Ki 158.49 nM None
Homo sapiens Tyrosine kinase non-receptor protein 2 Ki 1.585 nM None
Homo sapiens Tyrosine-protein kinase ABL Ki 100.0 nM None
Homo sapiens Tyrosine-protein kinase BLK Ki 1.585 nM None
Homo sapiens Tyrosine-protein kinase BTK Ki 79.43 nM None
Homo sapiens Tyrosine-protein kinase FER Ki 3.162 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki 50.12 nM None
Homo sapiens Tyrosine-protein kinase HCK Ki 5.012 nM None
Homo sapiens Tyrosine-protein kinase ITK/TSK Ki 7.943 nM None
Homo sapiens Tyrosine-protein kinase JAK2 Ki 0.7943 nM None
Homo sapiens Tyrosine-protein kinase JAK3 Ki 1.995 nM None
Homo sapiens Tyrosine-protein kinase LCK Ki 25.12 nM None
Homo sapiens Tyrosine-protein kinase Lyn Ki 6.31 nM None
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 12.59 nM None
Homo sapiens Tyrosine-protein kinase receptor RET IC50 2.195 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Ki 2.512 nM None
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 10.0 nM None
Homo sapiens Tyrosine-protein kinase SRC Ki 19.95 nM None
Homo sapiens Tyrosine-protein kinase SYK Ki 3.162 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 5.012 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 6.31 nM None
Homo sapiens Vascular endothelial growth factor receptor 3 Ki 6.31 nM None

Metabolism Information