Stylopine; (ξ)-form
AlkaPlorer ID: AK314651
Synonym: Fumjudaine
IUPAC Name: 5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene
Structure
SMILES: C1=CC2=C(OCO2)C2=C1CC1C3=C(C=C4OCOC4=C3)CCN1C2
InChI: InChI=1S/C19H17NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,6-7,15H,3-5,8-10H2
InChIKey: UXYJCYXWJGAKQY-UHFFFAOYSA-N
Reference
Insecticidal Alkaloids from <i>Corydalis bulbosa</i> against <i>Drosophila melanogaster</i>
PubChem CID: 6770
CAS: 2884-83-5
LOTUS: LTS0157696
NPASS: NPC234392
COCONUT: CNP0219682.2
data_source: manually
Source
Properties Information
Molecule Weight: 323.34800000000007
TPSA？: 40.16
MolLogP？: 2.799500000000001
Number of H-Donors: 0
Number of H-Acceptors: 5
RingCount: 6
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | GES1 | IC50 | 150000.0 | nM | 10.1016/j.bmc.2022.116705 |
| Homo sapiens | HGC-27 | IC50 | 55060.0 | nM | 10.1016/j.bmc.2022.116705 |
| Homo sapiens | MGC-803 | IC50 | 107300.0 | nM | 10.1016/j.bmc.2022.116705 |
| Influenza A virus (strain A/USSR/90/1977 H1N1) | Neuraminidase | IC50 | nan | None | 10.1016/j.bmc.2014.09.004 |
| Mus musculus | Mus musculus | Activity | nan | None | 10.1021/acs.jmedchem.5b00964 |
| None | Unchecked | IC50 | nan | None | 10.1016/j.bmc.2014.09.004 |
| None | Unchecked | Inhibition | 4.7 | % | 10.1016/j.bmc.2014.09.004 |