Zoamides; Zoamide B
AlkaPlorer ID: AK318140
Synonym: None
IUPAC Name: N-[2-methyl-12-(3-methylbut-2-enoylamino)-4,6,11,13-tetrazatricyclo[8.3.0.03,7]trideca-1(10),3(7),4,12-tetraen-5-yl]benzamide
Structure
SMILES: CC(C)=CC(O)=NC1=NC2=C(N1)C(C)C1=C(CC2)N=C(N=C(O)C2=CC=CC=C2)N1
InChI: InChI=1S/C22H24N6O2/c1-12(2)11-17(29)25-21-23-15-9-10-16-19(13(3)18(15)26-21)27-22(24-16)28-20(30)14-7-5-4-6-8-14/h4-8,11,13H,9-10H2,1-3H3,(H2,23,25,26,29)(H2,24,27,28,30)
InChIKey: FGULWWOROLZDAM-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Parazoanthus sp. | Parazoanthus | Parazoanthidae | Zoantharia | Anthozoa | Cnidaria | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 404.4740000000001
TPSA？: 122.54
MolLogP？: 4.573700000000002
Number of H-Donors: 4
Number of H-Acceptors: 4
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | PAX33/FOXO11 | IC50 | 17000.0 | nM | 10.1021/acs.jnatprod.2c00246 |
| Homo sapiens | PAX33/FOXO11 | Inhibition | nan | % | 10.1021/acs.jnatprod.2c00246 |
| None | Unchecked | Activity | nan | None | 10.1021/acs.jnatprod.2c00246 |