Hymenialdisine
AlkaPlorer ID: AK318873
Synonym: None
IUPAC Name: (4Z)-4-(2-amino-5-oxo-1H-imidazol-4-ylidene)-2-bromo-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
Structure
SMILES: N=C1N=C(O)/C(=C2\CCNC(=O)C3=C2C=C(Br)N3)N1
InChI: InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)/b7-4-
InChIKey: ATBAETXFFCOZOY-DAXSKMNVSA-N
Reference
New Alkaloids from the Indopacific Sponge <i>Stylissa carteri</i>
PubChem CID: 135413546
LOTUS: LTS0132354
NPASS: NPC184932
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Stylissa massa | Stylissa | Axinellidae | Axinellida | Demospongiae | Porifera | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 324.1379999999999
TPSA？: 113.36
MolLogP？: 1.11627
Number of H-Donors: 5
Number of H-Acceptors: 2
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bos taurus | Bos taurus | IC50 | 600.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Bos taurus | Bos taurus | IC50 | 800.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | Thermal melting change | -0.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | 786-0 | GI50 | 27542.29 | nM | None |
| Homo sapiens | A498 | GI50 | 45919.8 | nM | None |
| Homo sapiens | A498 | GI50 | 100000.0 | nM | None |
| Homo sapiens | A549 | GI50 | 70307.23 | nM | None |
| Homo sapiens | A549 | GI50 | 100000.0 | nM | None |
| Homo sapiens | ACHN | GI50 | 45289.76 | nM | None |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | Thermal melting change | 1.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | BT-549 | GI50 | 10351.42 | nM | None |
| Homo sapiens | Caco-2 | IC50 | 7799.0 | nM | 10.1021/jm0102856 |
| Homo sapiens | CAKI-1 | GI50 | 5688.53 | nM | None |
| Homo sapiens | CAKI-1 | GI50 | 33884.42 | nM | None |
| Homo sapiens | CaM kinase I delta | Thermal melting change | 0.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CaM kinase I gamma | Thermal melting change | -0.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CaM kinase II alpha | Thermal melting change | 0.4 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CaM kinase II beta | Thermal melting change | 0.4 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CaM kinase II delta | Thermal melting change | 0.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CaM kinase II gamma | Thermal melting change | 0.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CaM kinase IV | Thermal melting change | 0.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CaM-kinase kinase beta | Thermal melting change | 3.4 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | Thermal melting change | 0.8 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Casein kinase 2 | IC50 | 7000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Casein kinase I | IC50 | 35.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Casein kinase I delta | IC50 | 35.0 | nM | 10.1016/j.bmcl.2004.05.079 |
| Homo sapiens | Casein kinase I gamma 1 | Thermal melting change | 5.7 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Casein kinase I gamma 2 | Thermal melting change | 5.6 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Casein kinase II alpha | IC50 | 7000.0 | nM | 10.1016/j.bmcl.2004.05.079 |
| Homo sapiens | Casein kinase I isoform gamma-3 | Thermal melting change | 3.5 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | CCRF-CEM | GI50 | 1610.0 | nM | 10.1021/jm040013d |
| Homo sapiens | CCRF-CEM | GI50 | 2432.2 | nM | None |
| Homo sapiens | CCRF-CEM | GI50 | 2904.02 | nM | None |
| Homo sapiens | CDK1/Cyclin E | IC50 | 40.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | CDK3/Cyclin E | IC50 | 100.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | CDK6/cyclin D2 | IC50 | 700.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | COLO 205 | GI50 | 12618.28 | nM | None |
| Homo sapiens | COLO 205 | GI50 | 44258.84 | nM | None |
| Homo sapiens | Cyclin-dependent kinase 1/cyclin B | IC50 | 22.0 | nM | 10.1016/j.bmcl.2003.10.062 |
| Homo sapiens | Cyclin-dependent kinase 1/cyclin B | IC50 | 22.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Cyclin-dependent kinase 1/cyclin B | IC50 | 22.0 | nM | 10.1016/j.tips.2004.07.006 |
| Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | IC50 | 22.0 | nM | 10.1016/j.ejmech.2012.08.022 |
| Homo sapiens | Cyclin-dependent kinase 2 | Thermal melting change | 1.5 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Cyclin-dependent kinase 2/cyclin A | IC50 | 70.0 | nM | 10.1016/j.ejmech.2012.08.022 |
| Homo sapiens | Cyclin-dependent kinase 2/cyclin A | IC50 | 70.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Cyclin-dependent kinase 2/cyclin E1 | IC50 | 40.0 | nM | 10.1016/j.ejmech.2012.08.022 |
| Homo sapiens | Cyclin-dependent kinase 4/cyclin D1 | IC50 | 600.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Cyclin-dependent kinase 5 | IC50 | 30.0 | nM | 10.1007/s00044-012-0334-1 |
| Homo sapiens | Cyclin-dependent kinase 5/CDK5 activator 1 | IC50 | 25.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Cyclin-dependent kinase 5/CDK5 activator 1 | IC50 | 28.0 | nM | 10.1016/j.bmcl.2003.10.062 |
| Homo sapiens | Cyclin-dependent kinase 6 | Thermal melting change | 1.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Cyclin-dependent kinase-like 1 | Thermal melting change | 0.6 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Death-associated protein kinase 3 | Thermal melting change | 7.6 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | DLD-1 | GI50 | 37583.74 | nM | None |
| Homo sapiens | DMS-114 | GI50 | 13001.7 | nM | None |
| Homo sapiens | DMS-273 | GI50 | 85506.67 | nM | None |
| Homo sapiens | DNA topoisomerase I | IC50 | 10000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | DNA topoisomerase II alpha | IC50 | 10000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | DU-145 | GI50 | 39627.8 | nM | None |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | 6.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | 6.0 | nM | 10.1073/pnas.0708800104 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | 2500.0 | nM | 10.1021/jm0102856 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | Thermal melting change | 2.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 6 | Thermal melting change | 0.6 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Dual specificity protein kinase CLK2 | Thermal melting change | 5.6 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Dual specificity protein kinase CLK3 | Thermal melting change | 8.3 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Dual specificty protein kinase CLK1 | Thermal melting change | 9.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | EKVX | GI50 | 71285.3 | nM | None |
| Homo sapiens | EKVX | GI50 | 100000.0 | nM | None |
| Homo sapiens | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1007/s00044-007-9086-8 |
| Homo sapiens | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1016/j.bmcl.2003.10.062 |
| Homo sapiens | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1016/j.ejmech.2008.08.012 |
| Homo sapiens | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1016/j.ejmech.2012.08.022 |
| Homo sapiens | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1016/j.ejmech.2015.10.018 |
| Homo sapiens | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1016/j.ejmech.2016.09.058 |
| Homo sapiens | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1016/j.tips.2004.07.006 |
| Homo sapiens | Glycogen synthase kinase-3 beta | Thermal melting change | 7.4 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | HCC 2998 | GI50 | 55335.01 | nM | None |
| Homo sapiens | HCC 2998 | GI50 | 57942.87 | nM | None |
| Homo sapiens | HCT-116 | GI50 | 5571.86 | nM | None |
| Homo sapiens | HCT-116 | GI50 | 7161.43 | nM | None |
| Homo sapiens | HCT-15 | GI50 | 29716.66 | nM | None |
| Homo sapiens | HCT-15 | GI50 | 42461.96 | nM | None |
| Homo sapiens | HL-60 | GI50 | 1599.56 | nM | None |
| Homo sapiens | HL-60 | GI50 | 1655.77 | nM | None |
| Homo sapiens | HOP-18 | GI50 | 45081.67 | nM | None |
| Homo sapiens | HOP-62 | GI50 | 31915.38 | nM | None |
| Homo sapiens | HOP-62 | GI50 | 40831.94 | nM | None |
| Homo sapiens | HOP-92 | GI50 | 29174.27 | nM | None |
| Homo sapiens | HOP-92 | GI50 | 40831.94 | nM | None |
| Homo sapiens | Hs-578T | GI50 | 38636.7 | nM | None |
| Homo sapiens | HT-29 | GI50 | 27164.39 | nM | None |
| Homo sapiens | HT-29 | GI50 | 67764.15 | nM | None |
| Homo sapiens | IGROV-1 | GI50 | 30408.85 | nM | None |
| Homo sapiens | IGROV-1 | GI50 | 97051.0 | nM | None |
| Homo sapiens | Inactive serine/threonine-protein kinase VRK3 | Thermal melting change | 0.3 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Jurkat | IC50 | 2410.0 | nM | 10.1021/jm040013d |
| Homo sapiens | Jurkat | IC50 | 4000.0 | nM | 10.1016/j.bmcl.2022.129102 |
| Homo sapiens | K562 | GI50 | 3854.78 | nM | None |
| Homo sapiens | K562 | GI50 | 4102.04 | nM | None |
| Homo sapiens | KB 3-1 | IC50 | 3100.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | KM12 | GI50 | 48752.85 | nM | None |
| Homo sapiens | KM12 | GI50 | 100000.0 | nM | None |
| Homo sapiens | KM-20L2 | GI50 | 70145.53 | nM | None |
| Homo sapiens | LoVo | IC50 | 6.0 | nM | 10.1016/j.bmcl.2022.129102 |
| Homo sapiens | LoVo | IC50 | 710.0 | nM | 10.1021/jm0102856 |
| Homo sapiens | LOX IMVI | GI50 | 4570.88 | nM | None |
| Homo sapiens | LOX IMVI | GI50 | 4886.52 | nM | None |
| Homo sapiens | M14 | GI50 | 9885.53 | nM | None |
| Homo sapiens | M19-MEL | GI50 | 48528.85 | nM | None |
| Homo sapiens | Malme-3M | GI50 | 8830.8 | nM | None |
| Homo sapiens | Malme-3M | GI50 | 25118.86 | nM | None |
| Homo sapiens | MAP kinase ERK1 | IC50 | 470.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | MAP kinase ERK1 | Thermal melting change | 0.9 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | MAP kinase ERK2 | IC50 | 6.0 | nM | 10.1016/j.bmcl.2004.05.079 |
| Homo sapiens | MAP kinase ERK2 | IC50 | 9.0 | nM | 10.1021/jm0102856 |
| Homo sapiens | MAP kinase ERK2 | IC50 | 2000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | MAP kinase p38 beta | Thermal melting change | 0.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | MCF7 | GI50 | 40926.07 | nM | None |
| Homo sapiens | MCF7 | GI50 | 80723.5 | nM | None |
| Homo sapiens | MDA-MB-231 | GI50 | 4655.86 | nM | None |
| Homo sapiens | MDA-MB-435 | GI50 | 5584.7 | nM | None |
| Homo sapiens | MDA-N | GI50 | 1901.08 | nM | None |
| Homo sapiens | Mitogen-activated protein kinase 6 | Thermal melting change | -0.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 5 | IC50 | 150.0 | nM | 10.1016/j.bmcl.2008.05.040 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 5 | IC50 | 7000.0 | nM | 10.1016/j.bmcl.2008.05.040 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 5 | Thermal melting change | 10.4 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | MOLT-4 | GI50 | 3451.44 | nM | None |
| Homo sapiens | MOLT-4 | GI50 | 4275.63 | nM | None |
| Homo sapiens | MONO-MAC-6 | IC50 | 610.0 | nM | 10.1016/j.bmcl.2022.129102 |
| Homo sapiens | Myotonin-protein kinase | Thermal melting change | 2.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | NCI/ADR-RES | GI50 | 11912.42 | nM | None |
| Homo sapiens | NCI/ADR-RES | GI50 | 43351.09 | nM | None |
| Homo sapiens | NCI-H226 | GI50 | 21777.1 | nM | None |
| Homo sapiens | NCI-H226 | GI50 | 63973.48 | nM | None |
| Homo sapiens | NCI-H23 | GI50 | 52722.99 | nM | None |
| Homo sapiens | NCI-H23 | GI50 | 80909.59 | nM | None |
| Homo sapiens | NCI-H322M | GI50 | 12647.36 | nM | None |
| Homo sapiens | NCI-H322M | GI50 | 38370.72 | nM | None |
| Homo sapiens | NCI-H460 | GI50 | 65614.53 | nM | None |
| Homo sapiens | NCI-H460 | GI50 | 100000.0 | nM | None |
| Homo sapiens | NCI-H522 | GI50 | 2546.83 | nM | None |
| Homo sapiens | NCI-H522 | GI50 | 7430.19 | nM | None |
| Homo sapiens | NF-kappa-B-repressing factor | Inhibition | 46.0 | % | 10.1021/jm040013d |
| Homo sapiens | OVCAR-3 | GI50 | 4295.36 | nM | None |
| Homo sapiens | OVCAR-3 | GI50 | 10739.89 | nM | None |
| Homo sapiens | OVCAR-4 | GI50 | 15275.66 | nM | None |
| Homo sapiens | OVCAR-4 | GI50 | 17498.47 | nM | None |
| Homo sapiens | OVCAR-5 | GI50 | 52119.47 | nM | None |
| Homo sapiens | OVCAR-5 | GI50 | 57543.99 | nM | None |
| Homo sapiens | OVCAR-8 | GI50 | 7211.07 | nM | None |
| Homo sapiens | OVCAR-8 | GI50 | 10471.29 | nM | None |
| Homo sapiens | PC-3 | GI50 | 56623.93 | nM | None |
| Homo sapiens | PDZ-binding kinase | Thermal melting change | 0.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Protein kinase C alpha | IC50 | 700.0 | nM | 10.1016/j.bmcl.2004.05.079 |
| Homo sapiens | Protein kinase C beta | IC50 | 1200.0 | nM | 10.1016/j.bmcl.2004.05.079 |
| Homo sapiens | Protein kinase C (PKC) | IC50 | 500.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | Thermal melting change | 4.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | Thermal melting change | 6.3 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | RPMI-8226 | GI50 | 15631.48 | nM | None |
| Homo sapiens | RPMI-8226 | GI50 | 79799.47 | nM | None |
| Homo sapiens | RXF 393 | GI50 | 29716.66 | nM | None |
| Homo sapiens | RXF 393 | GI50 | 34593.94 | nM | None |
| Homo sapiens | Serine/threonine-protein kinase 10 | Thermal melting change | 4.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase 16 | Thermal melting change | 1.5 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase 17A | Thermal melting change | 14.8 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase 2 | Thermal melting change | 2.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase 25 | Thermal melting change | 3.5 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase 38 | Thermal melting change | 1.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | IC50 | 1900.0 | nM | 10.1016/j.bmcl.2008.12.001 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | IC50 | 1950.0 | nM | 10.1016/j.bmcl.2004.05.079 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | IC50 | 1950.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | IC50 | 42.0 | nM | 10.1016/j.bmcl.2004.05.079 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | IC50 | 42.0 | nM | 10.1016/j.ejmech.2012.08.022 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | IC50 | 42.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | Thermal melting change | 8.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | Thermal melting change | 5.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | Thermal melting change | 1.8 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | Thermal melting change | 4.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase NEK2 | Thermal melting change | 0.8 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase NEK6 | Thermal melting change | 0.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase OSR1 | Thermal melting change | 0.5 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | Thermal melting change | 1.6 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PAK6 | Thermal melting change | 1.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | Thermal melting change | 0.4 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | Thermal melting change | 0.1 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PIM1 | Thermal melting change | 0.7 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PIM2 | Thermal melting change | 3.7 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PIM3 | Thermal melting change | 3.8 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | Thermal melting change | 5.8 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | Thermal melting change | 3.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase RAF | IC50 | 10000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) | IC50 | 6.0 | nM | 10.1021/jm0102856 |
| Homo sapiens | Serine/threonine-protein kinase RIO2 | Thermal melting change | 0.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase VRK1 | Thermal melting change | 2.0 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Serine/threonine-protein kinase VRK2 | Thermal melting change | 0.8 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | SF-268 | GI50 | 5093.31 | nM | None |
| Homo sapiens | SF-268 | GI50 | 8933.05 | nM | None |
| Homo sapiens | SF-295 | GI50 | 100000.0 | nM | None |
| Homo sapiens | SF-539 | GI50 | 4285.49 | nM | None |
| Homo sapiens | SF-539 | GI50 | 13001.7 | nM | None |
| Homo sapiens | SK-MEL-2 | GI50 | 974.99 | nM | None |
| Homo sapiens | SK-MEL-2 | GI50 | 2904.02 | nM | None |
| Homo sapiens | SK-MEL-28 | GI50 | 7744.62 | nM | None |
| Homo sapiens | SK-MEL-28 | GI50 | 13772.09 | nM | None |
| Homo sapiens | SK-MEL-5 | GI50 | 19678.86 | nM | None |
| Homo sapiens | SK-MEL-5 | GI50 | 40550.85 | nM | None |
| Homo sapiens | SK-OV-3 | GI50 | 7655.97 | nM | None |
| Homo sapiens | SK-OV-3 | GI50 | 16106.46 | nM | None |
| Homo sapiens | SN12C | GI50 | 11324.0 | nM | None |
| Homo sapiens | SN12C | GI50 | 19543.39 | nM | None |
| Homo sapiens | SN12K1 | GI50 | 12274.39 | nM | None |
| Homo sapiens | SNB-19 | GI50 | 39084.09 | nM | None |
| Homo sapiens | SNB-19 | GI50 | 48194.78 | nM | None |
| Homo sapiens | SNB-75 | GI50 | 34833.73 | nM | None |
| Homo sapiens | SNB-75 | GI50 | 39994.47 | nM | None |
| Homo sapiens | SNB-78 | GI50 | 86297.85 | nM | None |
| Homo sapiens | SR | GI50 | 303.39 | nM | None |
| Homo sapiens | SW-620 | GI50 | 2716.44 | nM | None |
| Homo sapiens | SW-620 | GI50 | 6123.5 | nM | None |
| Homo sapiens | SW-620 | IC50 | 2000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | T47D | GI50 | 7870.46 | nM | None |
| Homo sapiens | THP-1 | IC50 | 1360.0 | nM | 10.1021/jm040013d |
| Homo sapiens | THP-1 | IC50 | 1400.0 | nM | 10.1016/j.bmcl.2022.129102 |
| Homo sapiens | THP-1 | IC50 | 1400.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | THP-1 | IC50 | 2400.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | TK-10 | GI50 | 9120.11 | nM | None |
| Homo sapiens | TRAF2- and NCK-interacting kinase | Thermal melting change | 4.7 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Tyrosine-protein kinase ABL | IC50 | 4000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | Thermal melting change | 0.2 | degrees C | 10.1073/pnas.0708800104 |
| Homo sapiens | Tyrosine-protein kinase SRC | IC50 | 7000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| Homo sapiens | U-251 | GI50 | 18578.04 | nM | None |
| Homo sapiens | U-251 | GI50 | 26424.09 | nM | None |
| Homo sapiens | UACC-257 | GI50 | 18323.14 | nM | None |
| Homo sapiens | UACC-257 | GI50 | 23713.74 | nM | None |
| Homo sapiens | UACC-62 | GI50 | 9616.12 | nM | None |
| Homo sapiens | UACC-62 | GI50 | 13427.65 | nM | None |
| Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 7 | Inhibition | 20.0 | % | 10.1016/j.bmcl.2013.04.066 |
| Homo sapiens | UO-31 | GI50 | 3019.95 | nM | None |
| Homo sapiens | UO-31 | GI50 | 5597.58 | nM | None |
| Homo sapiens | XF498 | GI50 | 100000.0 | nM | None |
| Human immunodeficiency virus 1 | Human immunodeficiency virus 1 | Inhibition | 30.0 | % | 10.1016/j.ejmech.2021.113445 |
| Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Inhibition | 90.0 | % | 10.1016/j.ejmech.2021.113445 |
| Mus musculus | L5178Y | EC50 | 3.5 | ug.mL-1 | 10.1016/j.ejmech.2021.113445 |
| Mus musculus | Mus musculus | Activity | 120.0 | % | 10.1016/j.ejmech.2021.113445 |
| Mus musculus | P388 | Activity | 2.4 | ug ml-1 | 10.1021/np700738k |
| Mus musculus | P388 | GI50 | 3971.92 | nM | None |
| Mus musculus | P388/ADR | GI50 | 7277.8 | nM | None |
| Plasmodium falciparum (isolate 3D7) | Glycogen synthase kinase 3 | IC50 | 23.0 | nM | 10.1021/acs.jmedchem.2c00996 |
| Rattus norvegicus | Glycogen synthase kinase-3 beta | IC50 | 10.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | NON-PROTEIN TARGET | IC50 | 0.2 | ug.mL-1 | 10.1021/np980315g |
| None | Unchecked | IC50 | 6.0 | nM | 10.1016/j.bmcl.2022.129102 |
| None | Unchecked | IC50 | 10.0 | nM | 10.1016/j.bmc.2007.03.048 |
| None | Unchecked | IC50 | 10.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | IC50 | 22.0 | nM | 10.1073/pnas.0708800104 |
| None | Unchecked | IC50 | 23.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | IC50 | 30.0 | nM | 10.1007/s00044-012-0334-1 |
| None | Unchecked | IC50 | 40.0 | nM | 10.1073/pnas.0708800104 |
| None | Unchecked | IC50 | 600.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | IC50 | 1200.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | IC50 | 1700.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | IC50 | 4000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | IC50 | 8000.0 | nM | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | Ratio IC50 | 46.0 | None | 10.1016/j.ejmech.2021.113445 |
| None | Unchecked | Selectivity index | 2.2 | None | 10.1016/j.bmcl.2003.10.062 |
| None | Unchecked | Selectivity Index | 2.2 | None | 10.1016/j.ejmech.2021.113445 |