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name Structure Reference Source Properties Activities Metabolism

Nifedipine

AlkaPlorer ID: AK318922

Synonym: None

IUPAC Name: dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Structure

SMILES: COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+](=O)[O-]

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InChI: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

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InChIKey: HYIMSNHJOBLJNT-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 346.33900000000006

TPSA？: 107.77

MolLogP？: 2.1756

Number of H-Donors: 1

Number of H-Acceptors: 7

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 26.35 % 10.6019/CHEMBL4513141
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 12589.3 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 17782.8 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 37289.8 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 39810.7 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 56234.1 nM None
Bos taurus Potassium channel subfamily K member 2 IC50 8200.0 nM 10.1021/acs.jmedchem.5b00671
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans Inhibition 4.72 % 10.6019/CHEMBL4513141
Canis lupus familiaris Canis familiaris BP -37.0 mmHg 10.1021/jm020597o
Canis lupus familiaris Canis familiaris CBF Ratio 104.0 None 10.1021/jm020597o
Canis lupus familiaris Canis familiaris Decrease 77.0 % 10.1021/jm00130a026
Canis lupus familiaris Canis familiaris Decrease 77.0 % 10.1021/jm00164a019
Canis lupus familiaris Canis familiaris Decrease 77.0 % 10.1021/jm00168a041
Canis lupus familiaris Canis familiaris Decrease in CVR 77.0 % 10.1021/jm00123a009
Canis lupus familiaris Canis familiaris Duration of action 36.0 min 10.1021/jm00164a019
Canis lupus familiaris Canis familiaris ED30 0.5 ug kg-1 10.1021/jm00130a029
Canis lupus familiaris Canis familiaris FBF Ratio -28.0 None 10.1021/jm020597o
Canis lupus familiaris Canis familiaris Inhibition 95.0 % 10.1021/jm00119a026
Canis lupus familiaris Canis familiaris T1/2 0.04167 hr 10.1021/jm00130a029
Canis lupus familiaris Canis familiaris T1/2 0.6 hr 10.1021/jm00123a009
Canis lupus familiaris Canis familiaris T1/2 0.6 hr 10.1021/jm00130a026
Canis lupus familiaris Canis familiaris Tp 0.7 min 10.1021/jm00130a029
Cavia porcellus Aorta Activity 82.0 % 10.1021/acs.jmedchem.6b00030
Cavia porcellus Aorta Activity 82.0 % 10.1021/jm301839q
Cavia porcellus Aorta IC50 9.0 nM 10.1016/j.ejmech.2018.12.003
Cavia porcellus Aorta IC50 9.0 nM 10.1016/j.ejmech.2019.02.075
Cavia porcellus Aorta IC50 9.0 nM 10.1021/acs.jmedchem.6b00030
Cavia porcellus Aorta IC50 9.0 nM 10.1021/jm200199r
Cavia porcellus Aorta IC50 9.0 nM 10.1021/jm301839q
Cavia porcellus Aorta Inhibition 82.0 % 10.1016/j.ejmech.2018.12.003
Cavia porcellus Aorta Inhibition 82.0 % 10.1016/j.ejmech.2019.02.075
Cavia porcellus Aorta Inhibition 82.0 % 10.1021/jm200199r
Cavia porcellus Cavia porcellus C175 0.013 uM 10.1021/jm00398a023
Cavia porcellus Cavia porcellus Control 85.0 % 10.1021/jm00398a023
Cavia porcellus Cavia porcellus EC30 0.0149 ug ml-1 10.1021/jm00167a033
Cavia porcellus Cavia porcellus EC30 0.11 ug ml-1 10.1021/jm00167a033
Cavia porcellus Cavia porcellus EC50 5.129 nM 10.1021/jm00119a009
Cavia porcellus Cavia porcellus EC50 2000000000.0 nM 10.1021/jm00090a014
Cavia porcellus Cavia porcellus EC50 8900000000.0 nM 10.1021/jm00090a014
Cavia porcellus Cavia porcellus IA 1.0 None 10.1021/jm00090a014
Cavia porcellus Cavia porcellus IC50 4.0 nM 10.1021/jm00072a017
Cavia porcellus Cavia porcellus IC50 4.7 nM 10.1021/jm00072a017
Cavia porcellus Cavia porcellus IC50 14.0 nM 10.1021/jm030333h
Cavia porcellus Cavia porcellus IC50 14.0 nM 10.1021/jm9704006
Cavia porcellus Cavia porcellus IC50 14.0 nM 10.1021/jm970529f
Cavia porcellus Cavia porcellus IC50 31.5 nM 10.1021/jm00072a017
Cavia porcellus Cavia porcellus IC50 57.8 nM 10.1021/jm00072a017
Cavia porcellus Cavia porcellus IC50 400.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus IC50 600.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus IC50 6000.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus IC50 12000.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus IC50 20000.0 nM 10.1021/jm00173a019
Cavia porcellus Cavia porcellus ID50 3e-09 M 10.1021/jm00360a001
Cavia porcellus Cavia porcellus ID50 5e-09 M 10.1021/jm00360a001
Cavia porcellus Cavia porcellus ID50 5.1e-09 M 10.1021/jm00186a029
Cavia porcellus Cavia porcellus ID50 5.1e-09 M 10.1021/jm00344a007
Cavia porcellus Cavia porcellus ID50 1e-06 M 10.1021/jm00360a001
Cavia porcellus Cavia porcellus Inhibition 70.0 % 10.1021/jm00090a014
Cavia porcellus Cavia porcellus Inhibition 95.0 % 10.1021/jm00090a014
Cavia porcellus Cavia porcellus Intrinsic activity 0.49 None 10.1021/jm00173a019
Cavia porcellus Cavia porcellus -Log IC25 7.5 None 10.1021/jm00159a022
Cavia porcellus Cavia porcellus P (Ei) 0.014 None 10.1021/jm00398a023
Cavia porcellus Cavia porcellus pIC25 7.5 None 10.1021/jm00105a004
Cavia porcellus Cavia porcellus pIC25 7.5 None 10.1021/jm00123a009
Cavia porcellus Cavia porcellus pIC25 7.5 None 10.1021/jm00130a026
Cavia porcellus Cavia porcellus pIC25 7.5 None 10.1021/jm00168a041
Cavia porcellus Cavia porcellus pIC25 8.0 None 10.1021/jm00164a019
Cavia porcellus Heart Activity -96.0 % 10.1021/jm070681+
Cavia porcellus Heart Activity -60.0 % 10.1021/jm070681+
Cavia porcellus Heart Activity -36.0 % 10.1021/jm070681+
Cavia porcellus Heart Activity 37.0 % 10.1021/jm070681+
Cavia porcellus Heart Activity 66.0 % 10.1021/jm070681+
Cavia porcellus Ileum Activ ity 47.3 % 10.1021/np060073h
Cavia porcellus Ileum Activity 70.0 % 10.1021/jm301839q
Cavia porcellus Ileum EC50 1.5 nM 10.1016/j.ejmech.2018.12.003
Cavia porcellus Ileum IC50 1.5 nM 10.1021/jm301839q
Cavia porcellus Ileum IC50 14.7 nM 10.1016/j.ejmech.2009.09.005
Cavia porcellus Ileum Inhibition 48.1 % 10.1016/j.bmcl.2009.08.060
Cavia porcellus Ileum Inhibition 48.1 % 10.1016/j.ejmech.2009.09.005
Cavia porcellus Ileum Inhibition 70.0 % 10.1016/j.ejmech.2018.12.003
Cavia porcellus Left atrium Activity 97.0 % 10.1016/j.ejmech.2018.12.003
Cavia porcellus Left atrium Activity 97.0 % 10.1016/j.ejmech.2019.02.075
Cavia porcellus Left atrium Activity 97.0 % 10.1021/acs.jmedchem.6b00030
Cavia porcellus Left atrium EC50 260.0 nM 10.1016/j.ejmech.2018.12.003
Cavia porcellus Left atrium EC50 260.0 nM 10.1016/j.ejmech.2019.02.075
Cavia porcellus Left atrium EC50 260.0 nM 10.1021/acs.jmedchem.6b00030
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Right atrium Activity 85.0 % 10.1016/j.ejmech.2018.12.003
Cavia porcellus Right atrium Activity 85.0 % 10.1016/j.ejmech.2019.02.075
Cavia porcellus Right atrium EC50 39.0 nM 10.1016/j.ejmech.2018.12.003
Cavia porcellus Right atrium EC50 39.0 nM 10.1016/j.ejmech.2019.02.075
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC30 1.6 10'-8M 10.1007/s00044-010-9534-8
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 2.6 nM 10.1007/s00044-011-9807-x
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 50.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 50.0 nM 10.1007/s00044-008-9112-5
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 69.0 nM 10.1007/s00044-010-9534-8
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 260.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 300.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C Inhibition nan % 10.1007/s00044-012-0211-y
Cryptococcus neoformans Cryptococcus neoformans Inhibition -4.99 % 10.6019/CHEMBL4513141
Cryptosporidium parvum Cryptosporidium parvum IC50 nan None 10.1016/j.bmc.2010.01.068
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1007/s00044-005-0140-0
Electrophorus electricus Acetylcholinesterase Ki 4000.0 nM 10.1007/s00044-005-0140-0
Electrophorus electricus Acetylcholinesterase Ki 251188.64 nM 10.1007/s00044-005-0140-0
Entamoeba histolytica Entamoeba histolytica IC50 nan None 10.1016/j.bmc.2010.01.068
Equus caballus Cholinesterase Inhibition nan % 10.1007/s00044-005-0140-0
Equus caballus Cholinesterase Ki 1200.0 nM 10.1007/s00044-005-0140-0
Equus caballus Cholinesterase Ki 5011.87 nM 10.1007/s00044-005-0140-0
Escherichia coli Escherichia coli Inhibition 3.8 % 10.6019/CHEMBL4513141
Escherichia coli K-12 Beta-lactamase AmpC Potency 354.8 nM None
Felis catus Felis catus ID50 6e-07 M 10.1021/jm00360a001
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 7924.5 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 12559.4 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 17740.7 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 11220.2 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 15848.9 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 28183.8 nM None
Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase ABHD5/Perilipin-5 IC50 7133.0 nM None
Homo sapiens 78 kDa glucose-regulated protein Potency 58478.9 nM None
Homo sapiens A549 IC50 100000.0 nM 10.1039/C9MD00108E
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 6740.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor AC50 11730.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 7701.0 nM None
Homo sapiens Adenosine A1 receptor Inhibition 50.0 % 10.1021/np50094a001
Homo sapiens Adenosine A1 receptor Ki 4492.0 nM None
Homo sapiens Adenosine A2a receptor AC50 2630.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki 22200.0 nM 10.1021/jm970084v
Homo sapiens Adenosine A2a receptor Ki 244000.0 nM 10.1021/jm970084v
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 480.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 7214.0 nM None
Homo sapiens Adenosine A3 receptor Ki 4078.0 nM None
Homo sapiens Adenosine A3 receptor Ki 8290.0 nM 10.1021/jm9600205
Homo sapiens Adenosine A3 receptor Ki 8290.0 nM 10.1021/jm960457c
Homo sapiens Adenosine A3 receptor Ki 10000.0 nM 10.1021/jm9600205
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 7943.3 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 8912.5 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 12589.3 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 15848.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 25118.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 39810.7 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor Potency 31622.8 nM None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Arachidonate 12-lipoxygenase Potency 22387.2 nM None
Homo sapiens Arachidonate 12-lipoxygenase Potency 31622.8 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 10000.0 nM None
Homo sapiens Ataxin-2 Potency 10000.0 nM None
Homo sapiens Ataxin-2 Potency 11220.2 nM None
Homo sapiens Ataxin-2 Potency 28183.8 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 8196.1 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 10322.5 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 18348.9 nM None
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 50500.0 nM 10.1016/j.ejmech.2022.114346
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor Potency 28183.8 nM None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile acid receptor FXR Potency 22387.2 nM None
Homo sapiens Bile acid receptor FXR Potency 25118.9 nM None
Homo sapiens Bile salt export pump IC50 18650.0 nM 10.1124/dmd.112.047068
Homo sapiens Bile salt export pump IC50 30700.0 nM 10.1124/dmd.111.040758
Homo sapiens Bile salt export pump IC50 64000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 69000.0 nM 10.1002/hep.27206
Homo sapiens Bloom syndrome protein Potency 3981.1 nM None
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 39810.7 nM None
Homo sapiens Caco-2 logPapp -4.61 None 10.1016/j.bmc.2011.03.011
Homo sapiens Caco-2 logPapp -4.49 None 10.1016/j.bmc.2011.03.011
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Calmodulin IC50 nan None 10.1016/j.bmc.2010.10.063
Homo sapiens Calmodulin Ratio IC50 nan None 10.1016/j.bmc.2010.10.063
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 2191.0 nM None
Homo sapiens C-C chemokine receptor type 2 Ki 847.0 nM None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cellular tumor antigen p53 Potency 31622.8 nM None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 2818.4 nM None
Homo sapiens Chromobox protein homolog 1 Potency 35481.3 nM None
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cystic fibrosis transmembrane conductance regulator Emax 58.0 meter/s 10.1021/jm200199r
Homo sapiens Cytochrome P450 1A2 AC50 39.81 nM None
Homo sapiens Cytochrome P450 1A2 AC50 50.12 nM None
Homo sapiens Cytochrome P450 1A2 IC50 300.0 nM None
Homo sapiens Cytochrome P450 1A2 IC50 2300.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 IC50 5420.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C19 Potency 7943.3 nM None
Homo sapiens Cytochrome P450 2C19 Potency 15848.9 nM None
Homo sapiens Cytochrome P450 2C9 AC50 15848.93 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 IC50 4080.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2C9 Potency 15848.9 nM None
Homo sapiens Cytochrome P450 2C9 Potency 31622.8 nM None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 IC50 50000.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2D6 Potency 39810.7 nM None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 2J2 IC50 3060.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 3A4 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 AC50 12589.25 nM None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 5620.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 3A4 IC50 10000.0 nM 10.1016/j.bmcl.2003.08.027
Homo sapiens Cytochrome P450 3A4 IC50 11000.0 nM 10.1016/j.bmcl.2010.12.089
Homo sapiens Cytochrome P450 3A4 IC50 46989.41 nM 10.1016/j.ejmech.2008.12.004
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition 88.0 % 10.1021/jm00159a007
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 Potency 12589.3 nM None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Cytochrome P450 3A4 Rate of oxidation 1.4 None 10.1021/jm00159a007
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 1122.0 nM None
Homo sapiens DNA polymerase iota Potency 39810.7 nM None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 26029.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D1 receptor Potency 2592.8 nM None
Homo sapiens Dopamine D1 receptor Potency 31622.8 nM None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 7943.3 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 10000.0 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 12589.3 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31622.8 nM None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor alpha Potency 50118.7 nM None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Eyes absent homolog 2 Potency 10692.8 nM None
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 12589.3 nM None
Homo sapiens Geminin Potency 20596.2 nM None
Homo sapiens Geminin Potency 29092.9 nM None
Homo sapiens Geminin Potency 33498.3 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glucocorticoid receptor Potency 31622.8 nM None
Homo sapiens Glutathione reductase IC50 23400.0 nM 10.1016/j.bmcl.2011.07.002
Homo sapiens Glutathione reductase Ki 17400.0 nM 10.1016/j.bmcl.2011.07.002
Homo sapiens HCT-116 IC50 100000.0 nM 10.1039/C9MD00108E
Homo sapiens HEK293 Potency 20587.8 nM None
Homo sapiens HEK293 Potency 23109.3 nM None
Homo sapiens HEK-293T Activity nan None 10.1016/j.bmcl.2012.10.010
Homo sapiens Hepatocyte CL 7.8 mL.min-1.kg-1 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte CL 17.1 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
Homo sapiens Hepatocyte logCL 0.8921 None 10.1016/j.ejmech.2008.07.027
Homo sapiens HepG2 I 80.5 % 10.1021/jm9604989
Homo sapiens HepG2 IC50 9400.0 nM 10.1016/j.bmcl.2018.12.020
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 50118.72 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 50118.72 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 50118.72 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 50118.72 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 275000.0 nM 10.1093/cvr/cvr044
Homo sapiens HERG IC50 280000.0 nM 10.1016/j.bmcl.2004.06.070
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor Ki nan None 10.1021/acs.jmedchem.9b00937
Homo sapiens Histone deacetylase 6 Inhibition -30.91 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 9.22 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 2993.5 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 4466.8 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 11220.2 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 14125.4 nM None
Homo sapiens Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens Histone-lysine N-methyltransferase MLL Potency 50118.7 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity nan None 10.1002/hep.27206
Homo sapiens Homo sapiens AUC 1204.92 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens CL 7.3 mL.min-1.kg-1 10.1021/acs.jmedchem.5b00201
Homo sapiens Homo sapiens CL 7.3 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 7.3 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 8.1 mL.min-1.kg-1 10.1124/dmd.111.042309
Homo sapiens Homo sapiens CL 175.0 mL.min-1.kg-1 10.1021/acs.jmedchem.7b00969
Homo sapiens Homo sapiens CL_renal 0.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Cmax 271.0 nM 10.1002/hep.27206
Homo sapiens Homo sapiens Css 0.145 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Drug uptake(free) 6.0 nM 10.1021/acs.jmedchem.7b00969
Homo sapiens Homo sapiens F 50.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens FC 1.42 None 10.1124/dmd.110.035071
Homo sapiens Homo sapiens FC 1.56 None 10.1124/dmd.110.035071
Homo sapiens Homo sapiens FC 1.61 None 10.1124/dmd.110.035071
Homo sapiens Homo sapiens FC 1.77 None 10.1124/dmd.110.035071
Homo sapiens Homo sapiens F_fraction 0.5 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.73 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.68 None 10.1021/jm901371v
Homo sapiens Homo sapiens IC50 100000000000.0 nM 10.1021/jm00118a004
Homo sapiens Homo sapiens T1/2 1.9 hr 10.1021/acs.jmedchem.5b00201
Homo sapiens Homo sapiens T1/2 2.0 hr 10.1021/acs.jmedchem.7b00969
Homo sapiens Homo sapiens Vdss 0.78 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens Homo sapiens Vdss 0.79 L.kg-1 10.1021/acs.jmedchem.5b00201
Homo sapiens Homo sapiens Vdss 0.79 L.kg-1 10.1021/jm901371v
Homo sapiens Hydroxycarboxylic acid receptor 2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 501.2 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 1000.0 nM None
Homo sapiens Indoleamine 2,3-dioxygenase IC50 nan None 10.1016/j.ejmech.2014.06.078
Homo sapiens Indoleamine 2,3-dioxygenase Inhibition 0.0 % 10.1016/j.ejmech.2014.06.078
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 5173.5 nM None
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes CL 149.1 mL.min-1.g-1 10.1016/j.bmcl.2011.12.005
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens Lymphoblastoid cell Potency 31622.8 nM None
Homo sapiens Lymphoblastoid cell Potency 39810.7 nM None
Homo sapiens Lymphoblastoid cell Potency 50118.7 nM None
Homo sapiens Lymphoblastoid cell Potency 79432.8 nM None
Homo sapiens Lymphoblastoid cell Potency 100000.0 nM None
Homo sapiens Lysine-specific demethylase 4A Potency 56234.1 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 14125.4 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 15848.9 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 22387.2 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 25118.9 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 28183.8 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Potency 25118.9 nM None
Homo sapiens MAP kinase ERK2 Potency 39810.7 nM None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 IC50 100000.0 nM 10.1039/C9MD00108E
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens microRNA 21 Potency 26121.6 nM None
Homo sapiens Microtubule-associated protein tau Potency 3548.1 nM None
Homo sapiens Microtubule-associated protein tau Potency 3981.1 nM None
Homo sapiens Microtubule-associated protein tau Potency 4466.8 nM None
Homo sapiens Microtubule-associated protein tau Potency 7943.3 nM None
Homo sapiens Microtubule-associated protein tau Potency 8912.5 nM None
Homo sapiens Microtubule-associated protein tau Potency 12589.3 nM None
Homo sapiens Microtubule-associated protein tau Potency 14125.4 nM None
Homo sapiens Microtubule-associated protein tau Potency 15848.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 19952.6 nM None
Homo sapiens Microtubule-associated protein tau Potency 22387.2 nM None
Homo sapiens MM1.S IC50 57900.0 nM 10.1039/C9MD00108E
Homo sapiens Monoamine oxidase A AC50 12999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 35481.3 nM None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens M-phase phosphoprotein 8 Potency 37685.8 nM None
Homo sapiens M-phase phosphoprotein 8 Potency 39810.7 nM None
Homo sapiens Multidrug resistance-associated protein 4 IC50 16600.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 10999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor ID50 1.4e-08 M 10.1021/jm00162a016
Homo sapiens Muscarinic acetylcholine receptor ID50 1.4 M 10.1021/jm00387a010
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Muscleblind-like protein 1 Potency 79432.8 nM None
Homo sapiens Myosin light chain kinase, smooth muscle IC50 2020.0 nM 10.1016/j.bmc.2015.09.009
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 12995.3 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 42163.2 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 59557.2 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 11220.2 nM None
Homo sapiens Nuclear receptor ROR-gamma Potency 66824.2 nM None
Homo sapiens Perilipin-1/ABHD5 IC50 9619.0 nM None
Homo sapiens Peripheral myelin protein 22 Potency 75686.3 nM None
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 11220.2 nM None
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 25118.9 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 15848.9 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 50118.7 nM None
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bbrc.2004.01.156
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/s0928-0987(00)00215-3
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1018877803319
Homo sapiens P-glycoprotein 1 Activity nan None 10.1074/jbc.m010173200
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 IC50 113000.0 nM 10.1021/tx010125x
Homo sapiens P-glycoprotein 1 IC50 472000.0 nM 10.1016/s0928-0987(02)00082-9
Homo sapiens P-glycoprotein 1 Inhibition 56.0 % 10.1023/a:1018877803319
Homo sapiens P-glycoprotein 1 % maximum response 34.8 % None
Homo sapiens P-glycoprotein 1 Papp 610.0 nm/s None
Homo sapiens P-glycoprotein 1 Papp 765.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 2.08 None None
Homo sapiens P-glycoprotein 1 Ratio_Papp 1.26 None None
Homo sapiens Phosphodiesterase 1C IC50 10000.0 nM 10.1021/acs.jmedchem.2c00458
Homo sapiens Phosphodiesterase 3A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma fCmax 0.012 uM 10.1124/dmd.111.040758
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor Activity nan None None
Homo sapiens Prelamin-A/C Potency 1122.0 nM None
Homo sapiens Prelamin-A/C Potency 22387.2 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 59.7 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 2119.2 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 79432.8 nM None
Homo sapiens Retinoid X receptor alpha Potency 44668.4 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 16481.6 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Potency 4744.4 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 6800.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 18273.0 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 9572.0 nM None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SH-SY5Y Activity 11.7 % 10.1021/jm500263v
Homo sapiens SH-SY5Y Activity 12.4 % 10.1039/C3MD20345J
Homo sapiens SH-SY5Y Activity 15.76 % 10.1039/C3MD20345J
Homo sapiens SH-SY5Y Activity 15.8 % 10.1021/jm500263v
Homo sapiens SH-SY5Y Activity 20.0 % 10.1021/jm500263v
Homo sapiens SH-SY5Y Activity 24.0 % 10.1016/j.ejmech.2015.12.043
Homo sapiens SH-SY5Y Activity 29.3 % 10.1021/jm500263v
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2014.04.075
Homo sapiens SH-SY5Y Inhibition 36.0 % 10.1021/jm901902w
Homo sapiens SH-SY5Y Inhibition 45.0 % 10.1016/j.ejmech.2011.03.003
Homo sapiens SH-SY5Y Inhibition 59.75 % 10.1039/C3MD20345J
Homo sapiens SH-SY5Y Potency 28183.8 nM None
Homo sapiens SH-SY5Y Survival 55.03 % 10.1039/C3MD20345J
Homo sapiens SH-SY5Y Survival 58.7 % 10.1021/jm500263v
Homo sapiens SH-SY5Y Survival 58.71 % 10.1039/C3MD20345J
Homo sapiens SH-SY5Y Survival 62.9 % 10.1021/jm500263v
Homo sapiens SH-SY5Y Survival 73.8 % 10.1021/jm500263v
Homo sapiens SH-SY5Y Survival 78.4 % 10.1021/jm500263v
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Skin log Kp -6.63 None 10.1016/j.bmc.2007.07.050
Homo sapiens Sodium channel alpha subunit IC50 37000.0 nM 10.1093/cvr/cvr044
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) IC50 37000.0 nM 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 26.0 % 10.1021/jm00381a019
Homo sapiens Sodium channel protein type V alpha subunit AC50 12000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 63.7 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 75.83 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition -21.0 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 170.58 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -44.4 % 10.1021/jm300212s
Homo sapiens Survival motor neuron protein Potency 5623.4 nM None
Homo sapiens Survival motor neuron protein Potency 19952.6 nM None
Homo sapiens Survival motor neuron protein Potency 28183.8 nM None
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thrombopoietin Potency 1584.9 nM None
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 18594.0 nM None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid stimulating hormone receptor Potency 158.5 nM None
Homo sapiens TNF-alpha Potency 10590.9 nM None
Homo sapiens Type-1 angiotensin II receptor AC50 36330.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2592.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5173.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 7079.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 9200.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 9441.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 10000.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11582.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11885.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 12995.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 17782.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 22387.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23715.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29855.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 44668.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 50118.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 56234.1 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 35481.3 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 3162.3 nM None
Homo sapiens Vitamin D receptor Potency 3548.1 nM None
Homo sapiens Vitamin D receptor Potency 3981.1 nM None
Homo sapiens Vitamin D receptor Potency 5623.4 nM None
Homo sapiens Vitamin D receptor Potency 6309.6 nM None
Homo sapiens Vitamin D receptor Potency 7079.5 nM None
Homo sapiens Vitamin D receptor Potency 8912.5 nM None
Homo sapiens Vitamin D receptor Potency 10000.0 nM None
Homo sapiens Vitamin D receptor Potency 11220.2 nM None
Homo sapiens Vitamin D receptor Potency 15848.9 nM None
Homo sapiens Vitamin D receptor Potency 25118.9 nM None
Homo sapiens Vitamin D receptor Potency 29092.9 nM None
Homo sapiens Vitamin D receptor Potency 39810.7 nM None
Homo sapiens Voltage-gated calcium channel Inhibition 32.0 % 10.1016/j.bmc.2018.04.019
Homo sapiens Voltage-gated calcium channel Inhibition 40.0 % 10.1016/j.ejmech.2018.07.030
Homo sapiens Voltage-gated calcium channel Inhibition 73.0 % 10.1021/acs.jmedchem.6b00478
Homo sapiens Voltage-gated L-type calcium channel Activity 34.4 % 10.1016/j.ejmech.2019.02.075
Homo sapiens Voltage-gated L-type calcium channel Activity 55.0 % 10.1016/j.ejmech.2019.02.075
Homo sapiens Voltage-gated L-type calcium channel Activity 73.7 % 10.1016/j.ejmech.2019.02.075
Homo sapiens Voltage-gated L-type calcium channel Activity 101.6 % 10.1016/j.ejmech.2019.02.075
Homo sapiens Voltage-gated L-type calcium channel Binding energy -13.18 kCal M-1 10.1021/jm981114c
Homo sapiens Voltage-gated L-type calcium channel Binding energy -12.38 kCal M-1 10.1021/jm981114c
Homo sapiens Voltage-gated L-type calcium channel Binding energy -10.5 kCal M-1 10.1021/jm981114c
Homo sapiens Voltage-gated L-type calcium channel IC50 10.0 nM 10.1038/srep02100
Homo sapiens Voltage-gated L-type calcium channel IC50 60.0 nM 10.1093/cvr/cvr044
Homo sapiens Voltage-gated L-type calcium channel IC50 22000.0 nM 10.1021/acs.jmedchem.9b00937
Homo sapiens Voltage-gated L-type calcium channel Inhibition 39.0 % 10.1021/acs.jmedchem.9b00937
Homo sapiens Voltage-gated L-type calcium channel Ki 14.45 nM 10.1016/j.bmc.2017.04.008
Homo sapiens Voltage-gated L-type calcium channel Ki 15.0 nM 10.1016/j.bmc.2017.04.008
Homo sapiens Voltage-gated L-type calcium channel -Log KD50 9.08 None 10.1021/jm00387a010
Homo sapiens Voltage-gated L-type calcium channel Relative activity 100.0 None 10.1021/jm00344a007
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit AC50 46000.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit Bmax1 100.0 % 10.1021/jm00400a008
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 22.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 50.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 55.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit Kd 0.4 nM 10.1021/jm00001a017
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit Kd1 0.39 nM 10.1021/jm00400a008
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit Ki 1.0 nM 10.1021/jm00387a019
Homo sapiens Voltage-gated L-type calcium channel alpha-1D subunit IC50 1350.0 nM 10.1021/jm500263v
Homo sapiens Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 IC50 1120.0 nM None
Homo sapiens Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 IC50 10100.0 nM None
Homo sapiens Voltage-gated potassium channel subunit Kv1.1 IC50 96000.0 nM 10.1021/acs.jmedchem.6b01262
Homo sapiens Voltage-gated potassium channel subunit Kv1.5 IC50 6100.0 nM 10.1016/j.bmcl.2008.10.099
Homo sapiens Whole blood Retention_time 6.4 min 10.1007/s00044-012-9977-1
Influenza A virus Nonstructural protein 1 Potency 63095.7 nM None
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 22.28 % 10.6019/CHEMBL4513141
Leishmania amazonensis Leishmania amazonensis IC50 117890.0 nM 10.1016/j.bmc.2010.09.015
Leishmania amazonensis Leishmania amazonensis IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania braziliensis Leishmania braziliensis IC50 95740.0 nM 10.1016/j.bmc.2010.09.015
Leishmania chagasi Leishmania chagasi IC50 146410.0 nM 10.1016/j.bmc.2010.09.015
Leishmania chagasi Leishmania chagasi IC50 176240.0 nM 10.1016/j.bmc.2010.09.015
Leishmania donovani Leishmania donovani IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania infantum Leishmania infantum IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania major Leishmania major IC50 181090.0 nM 10.1016/j.bmc.2010.09.015
Leishmania major Leishmania major IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania mexicana Leishmania mexicana IC50 nan None 10.1016/j.bmc.2010.01.068
Macaca mulatta LLC-MK2 IC50 588730.0 nM 10.1016/j.bmc.2010.09.015
Mus musculus Canalicular multispecific organic anion transporter 2 Activity nan None 10.1124/dmd.31.11.1296
Mus musculus Indoleamine 2,3-dioxygenase 1 IC50 46000.0 nM 10.1016/j.bmcl.2012.10.010
Mus musculus Indoleamine 2,3-dioxygenase 2 IC50 1500.0 nM 10.1016/j.bmcl.2012.10.010
Mus musculus Indoleamine 2,3-dioxygenase 2 Inhibition 55.0 % 10.1016/j.bmcl.2012.10.010
Mus musculus L-type calcium channel IC50 1200.0 nM 10.1021/np50097a004
Mus musculus L-type calcium channel Inhibition nan % None
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus Activity nan None 10.1007/s00044-011-9904-x
Mus musculus Mus musculus Concentration 1.0 % 10.1021/jm00119a026
Mus musculus Mus musculus ED50 2.4 mg.kg-1 10.1021/jm00118a004
Mus musculus Mus musculus ED50 6.93 umol.kg-1 10.1021/jm00118a004
Mus musculus Mus musculus ID50 30.0 mg.kg-1 10.1021/jm00400a006
Mus musculus Mus musculus TIME 0.6777 hr 10.1007/s00044-008-9112-5
Mus musculus Mus musculus TIME 0.7313 hr 10.1007/s00044-008-9112-5
Mus musculus Mus musculus TIME 0.805 hr 10.1007/s00044-008-9112-5
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 3162.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 7079.5 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 7943.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 10000.0 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 11220.2 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 12589.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 28183.8 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 35481.3 nM None
Mus musculus Transient receptor potential cation channel subfamily A member 1 EC50 400.0 nM 10.1021/jm100062h
Mus musculus Tryptophan 2,3-dioxygenase Inhibition 20.0 % 10.1016/j.bmcl.2012.10.010
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 15101.0 nM None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Oryctolagus cuniculus EC30 0.00397 ug ml-1 10.1021/jm00167a033
Oryctolagus cuniculus Oryctolagus cuniculus EC30 2.2 M 10.1021/jm00400a006
Oryctolagus cuniculus Oryctolagus cuniculus EC50 30000.0 nM 10.1021/jm00001a017
Oryctolagus cuniculus Oryctolagus cuniculus IC50 0.5 nM 10.1021/jm00400a008
Oryctolagus cuniculus Oryctolagus cuniculus IC50 1.0 nM 10.1021/jm00387a009
Oryctolagus cuniculus Oryctolagus cuniculus IC50 2.0 nM 10.1021/jm00095a023
Oryctolagus cuniculus Oryctolagus cuniculus IC50 2.5 nM 10.1016/S0960-894X(01)80810-6
Oryctolagus cuniculus Oryctolagus cuniculus IC50 6.9 nM 10.1021/jm00072a017
Oryctolagus cuniculus Oryctolagus cuniculus IC50 19.0 nM 10.1021/jm00001a017
Oryctolagus cuniculus Oryctolagus cuniculus IC50 113.1 nM 10.1021/jm00091a008
Oryctolagus cuniculus Oryctolagus cuniculus IC50 200.0 nM 10.1021/jm00403a030
Oryctolagus cuniculus Oryctolagus cuniculus Inhibition 18.28 % 10.1021/jm00118a004
Oryctolagus cuniculus Oryctolagus cuniculus Inhibition 41.73 % 10.1021/jm00118a004
Oryctolagus cuniculus Oryctolagus cuniculus Inhibition 73.66 % 10.1021/jm00118a004
Oryctolagus cuniculus Oryctolagus cuniculus Inhibition 88.35 % 10.1021/jm00118a004
Oryctolagus cuniculus Oryctolagus cuniculus Inhibition 100.0 % 10.1021/jm00118a004
Oryctolagus cuniculus Oryctolagus cuniculus Inhibition nan % 10.1021/jm00118a004
Oryctolagus cuniculus Oryctolagus cuniculus Kb 1000.0 nM 10.1016/S0960-894X(01)81229-4
Oryctolagus cuniculus Oryctolagus cuniculus Kd 0.1585 nM 10.1021/jm00114a009
Oryctolagus cuniculus Oryctolagus cuniculus Recovery 71.6 % 10.1021/jm00091a008
Oryctolagus cuniculus Oryctolagus cuniculus Relative potency 1.0 None 10.1021/jm00091a008
Oryctolagus cuniculus Oryctolagus cuniculus Vascular relaxation 75.0 % 10.1021/jm00378a039
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect -3.1 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect -1.7 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect -1.2 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect -1.1 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect -1.0 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect 1.0 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect 3.5 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect 6.1 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect 24.7 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect 65.8 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect 89.4 None 10.1021/jm00111a047
Oryctolagus cuniculus Oryctolagus cuniculus Vasorelaxant effect 92.6 None 10.1021/jm00111a047
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit IC50 1.0 nM 10.1021/jm00119a026
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit IC50 2.9 nM 10.1021/jm00091a008
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit Inhibition 69.0 % 10.1016/j.bmc.2010.03.038
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit T1/2 0.04 hr 10.1021/jm00091a008
Plasmodium falciparum Plasmodium falciparum IC50 7943.28 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum Potency 11689.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 13115.4 nM None
Plasmodium falciparum Plasmodium falciparum Potency 16511.3 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Plasmodium falciparum Plasmodium falciparum Potency 19011.5 nM None
Pneumocystis carinii Pneumocystis carinii IC50 nan None 10.1016/j.bmc.2010.01.068
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 24.23 % 10.6019/CHEMBL4513141
Rattus norvegicus Adenosine A1 receptor Ki 2890.0 nM 10.1021/jm9600205
Rattus norvegicus Adenosine A1 receptor Ki 2890.0 nM 10.1021/jm960457c
Rattus norvegicus Adenosine A1 receptor Ki 10000.0 nM 10.1021/jm9600205
Rattus norvegicus Adenosine A2a receptor Ki 10000.0 nM 10.1021/jm9600205
Rattus norvegicus Adenosine A2a receptor Ki 18200.0 nM 10.1021/jm9600205
Rattus norvegicus Adrenergic receptor alpha-1 Ki 1000.0 nM 10.1016/S0960-894X(01)81229-4
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Aorta Activity 0.0 % 10.1021/np50123a013
Rattus norvegicus Aorta Activity 0.0 % 10.1021/np960354x
Rattus norvegicus Aorta Activity 0.0 % 10.1021/np9700735
Rattus norvegicus Aorta Activity 0.0 % 10.1021/np980471n
Rattus norvegicus Aorta Activity 12.0 % 10.1021/acs.jmedchem.9b00937
Rattus norvegicus Aorta Activity 37.0 % 10.1021/acs.jmedchem.9b00937
Rattus norvegicus Aorta Activity 81.0 % 10.1021/acs.jmedchem.9b00937
Rattus norvegicus Aorta Activity 96.5 % 10.1021/np50123a013
Rattus norvegicus Aorta EC50 30.0 nM 10.1016/j.ejmech.2013.10.018
Rattus norvegicus Aorta EC50 4310.0 nM 10.1021/np300508v
Rattus norvegicus Aorta EC50 nan None 10.1016/j.ejmech.2013.10.018
Rattus norvegicus Aorta EC50 nan None 10.1021/np300508v
Rattus norvegicus Aorta Efficacy 97.0 % 10.1016/j.ejmech.2013.10.018
Rattus norvegicus Aorta Efficacy 97.0 % 10.1021/np300508v
Rattus norvegicus Aorta Efficacy nan None 10.1016/j.ejmech.2013.10.018
Rattus norvegicus Aorta Efficacy nan None 10.1021/np300508v
Rattus norvegicus Aorta Emax 75.1 % 10.1039/C9MD00108E
Rattus norvegicus Aorta Emax 98.7 % 10.1039/C9MD00108E
Rattus norvegicus Aorta Emax 102.17 % 10.1016/j.bmc.2010.10.063
Rattus norvegicus Aorta Emax nan None 10.1016/j.bmc.2010.10.063
Rattus norvegicus Aorta IC50 2.9 nM 10.1039/C9MD00108E
Rattus norvegicus Aorta IC50 19.0 nM 10.1039/C9MD00108E
Rattus norvegicus Aorta IC50 20.0 nM 10.1016/j.bmc.2010.10.063
Rattus norvegicus Aorta IC50 nan None 10.1016/j.bmc.2010.10.063
Rattus norvegicus Bile salt export pump IC50 45400.0 nM 10.1124/dmd.111.040758
Rattus norvegicus C6-BU-1 IC50 1000.0 nM 10.1016/s0960-894x(03)00560-2
Rattus norvegicus Canalicular multispecific organic anion transporter 1 Activity nan None 10.1023/a:1016020626941
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Hippocampus Activity nan None 10.1021/jm500263v
Rattus norvegicus Inositol monophosphatase 1 Potency 8912.5 nM None
Rattus norvegicus Inositol monophosphatase 1 Potency 11220.2 nM None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver IC50 nan None 10.1002/hep.27206
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 15848.9 nM None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Potency 70794.6 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 18105.6 nM None
Rattus norvegicus Plasma Fu 0.044 None 10.1021/jm901371v
Rattus norvegicus Plasma logFu 0.04 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Rattus norvegicus Activity 0.04 mV 10.1007/s00044-010-9374-6
Rattus norvegicus Rattus norvegicus Activity 0.1 mV 10.1007/s00044-010-9374-6
Rattus norvegicus Rattus norvegicus Activity 0.15 mV 10.1007/s00044-010-9374-6
Rattus norvegicus Rattus norvegicus Activity 1.12 pmol/ml 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 1.28 pmol/ml 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 1.49 pmol/ml 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 1.62 pmol/ml 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 1.76 pmol/ml 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 1.97 mm 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 2.02 mm 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 2.04 pmol/ml 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 2.37 pmol/ml 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 3.19 mm 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 3.23 mm 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 4.69 mm 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 7.47 mmHg 10.1016/j.bmcl.2020.127604
Rattus norvegicus Rattus norvegicus Activity 8.32 mm 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 10.8 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 13.33 mmHg 10.1016/j.bmcl.2020.127604
Rattus norvegicus Rattus norvegicus Activity 14.3 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 17.1 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 18.96 mmHg 10.1016/j.bmcl.2020.127604
Rattus norvegicus Rattus norvegicus Activity 21.0 % 10.1016/j.bmc.2015.01.003
Rattus norvegicus Rattus norvegicus Activity 23.6 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 27.58 mmHg 10.1016/j.bmcl.2020.127604
Rattus norvegicus Rattus norvegicus Activity 29.8 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 32.1 % 10.1016/j.bmc.2015.01.003
Rattus norvegicus Rattus norvegicus Activity 33.0 % 10.1016/S0960-894X(00)80411-4
Rattus norvegicus Rattus norvegicus Activity 33.3 % 10.1016/j.ejmech.2013.06.006
Rattus norvegicus Rattus norvegicus Activity 34.1 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 36.3 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 42.79 % 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 43.0 % 10.1016/j.bmc.2015.01.003
Rattus norvegicus Rattus norvegicus Activity 56.8 % 10.1016/j.ejmech.2013.12.001
Rattus norvegicus Rattus norvegicus Activity 66.6 % 10.1016/j.ejmech.2013.06.006
Rattus norvegicus Rattus norvegicus Activity 72.6 % 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity 83.6 % 10.1016/j.bmc.2015.01.003
Rattus norvegicus Rattus norvegicus Activity 110.4 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 118.7 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 132.4 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 140.9 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 143.8 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 151.2 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 161.1 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 168.4 mmHg 10.1021/np50104a019
Rattus norvegicus Rattus norvegicus Activity 278.5 bpm 10.1007/s00044-011-9700-7
Rattus norvegicus Rattus norvegicus Activity 363.63 bpm 10.1007/s00044-010-9374-6
Rattus norvegicus Rattus norvegicus Activity 425.61 bpm 10.1007/s00044-010-9374-6
Rattus norvegicus Rattus norvegicus Activity 521.73 bpm 10.1007/s00044-010-9374-6
Rattus norvegicus Rattus norvegicus Activity nan None 10.1007/s00044-013-0542-3
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/s0960-894x(99)00691-5
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Rattus norvegicus Activity nan None 10.1039/C8MD00611C
Rattus norvegicus Rattus norvegicus ALB 25000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 26000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 27000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 28000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 29000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 45000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 46000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALBGLOB 0.8 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 0.9 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 159.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 225.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 361.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 414.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 975.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1032.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1068.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1072.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1129.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1236.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1242.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1290.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1305.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1317.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1341.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1381.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1399.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1407.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1423.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1438.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1439.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1457.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1485.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1503.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1508.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1549.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1571.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1579.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1580.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1580.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1620.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1646.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1654.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1663.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1854.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 2046.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 35.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 36.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 39.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 41.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 41.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 46.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 47.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 47.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 48.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 49.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 50.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 50.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 51.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 51.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 54.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 57.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus APTT 14.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 15.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 15.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 15.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 16.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 17.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 17.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 17.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 18.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 18.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 19.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 63.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 64.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 65.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 65.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 66.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 69.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 70.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 74.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 75.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 76.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 78.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 78.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 79.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 82.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 83.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 91.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 102.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BASOLE 0.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.02 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.06 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.08 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.1 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.12 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.14 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.16 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.18 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.18 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.22 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.24 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.26 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.28 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.3 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.32 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.34 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.36 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.4 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.42 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.44 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.46 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.52 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.54 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 82.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 90.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 94.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 120.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 142.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 146.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 150.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 152.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 154.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 172.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 174.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 176.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 178.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 182.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 186.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 190.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 216.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 232.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 262.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 268.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 276.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 322.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 324.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 402.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 418.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 103.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 104.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 105.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 106.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 107.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 109.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 110.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 111.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 112.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 113.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 116.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 117.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 118.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Change -35.0 % 10.1021/jm00114a009
Rattus norvegicus Rattus norvegicus Change -30.0 % 10.1021/jm00114a009
Rattus norvegicus Rattus norvegicus CHLORIDE 97.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 106.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 406.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 520.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 646.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 672.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 684.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 688.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 702.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 730.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 736.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 750.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 754.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 762.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 774.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 778.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 780.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 788.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 790.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 796.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 816.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 816.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 822.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 824.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 834.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 838.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 842.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 864.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 878.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 894.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 902.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 906.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 906.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 908.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 910.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CK 184.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 210.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 276.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 720.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cl 96.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 96.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 97.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 97.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 98.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 98.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 100.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 102.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 104.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 104.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 109.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CO2 18000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 23000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 3.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Decrease 25.0 % 10.1021/jm00387a009
Rattus norvegicus Rattus norvegicus Duration 3.0 min 10.1021/jm00091a008
Rattus norvegicus Rattus norvegicus EC25 10.0 nM 10.1021/jm00403a030
Rattus norvegicus Rattus norvegicus EC25 300.0 nM 10.1021/jm00403a030
Rattus norvegicus Rattus norvegicus EC50 3.2 nM 10.1021/jm9803267
Rattus norvegicus Rattus norvegicus EC50 iGC 3.4 nM 10.1021/jm9803267
Rattus norvegicus Rattus norvegicus ED25 31.0 ug kg-1 10.1021/jm00091a008
Rattus norvegicus Rattus norvegicus ED25 33.0 ug kg-1 10.1021/jm00091a008
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 32.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 136.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2526.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2534.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2604.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2674.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2678.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2710.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2770.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2782.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2796.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2814.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2816.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2826.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2834.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2852.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2858.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2866.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2870.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2880.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2922.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2926.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2932.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2970.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2980.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2986.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2992.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3136.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3208.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3740.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 0.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1370.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1376.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1426.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1530.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1556.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1604.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1628.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1636.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1650.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1658.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1670.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1678.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1726.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1728.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1734.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1748.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1770.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1774.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1778.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1784.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1786.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1792.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1836.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1840.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1870.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1928.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1934.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2174.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2206.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2214.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2276.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2296.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2608.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2636.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 33.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.57 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 38.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.1 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 40.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.53 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 40.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 43.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 44.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 44.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 127000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 128000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 128000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 130000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 131000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 132000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 133000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 134000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 136000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 137000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 138000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 139000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 140000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 141000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 141700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 143000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 145000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 148000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 149000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 152700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Hill coefficient 1.105 None 10.1021/jm00162a013
Rattus norvegicus Rattus norvegicus IC50 1.16 nM 10.1021/jm00084a002
Rattus norvegicus Rattus norvegicus IC50 1.2 nM 10.1021/jm00062a015
Rattus norvegicus Rattus norvegicus IC50 2.0 nM 10.1021/jm00107a009
Rattus norvegicus Rattus norvegicus IC50 2.5 nM 10.1021/jm00106a048
Rattus norvegicus Rattus norvegicus IC50 3.6 nM 10.1021/jm960270l
Rattus norvegicus Rattus norvegicus IC50 3.981 nM 10.1021/jm00105a004
Rattus norvegicus Rattus norvegicus IC50 3.981 nM 10.1021/jm00123a009
Rattus norvegicus Rattus norvegicus IC50 3.981 nM 10.1021/jm00130a026
Rattus norvegicus Rattus norvegicus IC50 3.981 nM 10.1021/jm00159a022
Rattus norvegicus Rattus norvegicus IC50 3.981 nM 10.1021/jm00168a041
Rattus norvegicus Rattus norvegicus IC50 4.0 nM 10.1016/S0960-894X(00)80411-4
Rattus norvegicus Rattus norvegicus IC50 4.0 nM 10.1021/jm00107a009
Rattus norvegicus Rattus norvegicus IC50 8.8 nM 10.1021/jm00387a019
Rattus norvegicus Rattus norvegicus IC50 31.62 nM 10.1021/jm00164a019
Rattus norvegicus Rattus norvegicus Inhibition 1.29 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 1.5 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 2.51 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 3.1 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 4.44 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 4.89 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 6.22 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 7.7 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 10.67 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 11.3 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 11.72 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 12.92 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 13.78 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 14.22 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 16.0 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 16.9 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 17.5 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 18.6 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 19.11 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 19.69 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 23.11 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 23.55 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 24.1 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 24.98 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 25.6 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 26.67 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 30.8 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 32.3 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 32.89 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 35.49 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 37.33 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 38.1 % 10.1016/j.ejmech.2010.08.022
Rattus norvegicus Rattus norvegicus Inhibition 39.41 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 41.78 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 44.2 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 44.51 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 45.51 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 46.58 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 47.56 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 48.39 % 10.1016/j.ejmech.2009.02.021
Rattus norvegicus Rattus norvegicus Inhibition 52.0 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 53.78 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Inhibition 54.22 % 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus Kb 0.5 nM 10.1016/S0960-894X(01)80771-X
Rattus norvegicus Rattus norvegicus Kb 0.5 nM 10.1016/S0960-894X(01)81229-4
Rattus norvegicus Rattus norvegicus Kd 0.1479 nM 10.1021/jm00107a009
Rattus norvegicus Rattus norvegicus Kd 12000.0 nM 10.1021/jm00107a001
Rattus norvegicus Rattus norvegicus Kd' 4.1e-10 M 10.1021/jm00107a001
Rattus norvegicus Rattus norvegicus LD50 210.0 mg.kg-1 10.1016/j.bmcl.2005.11.043
Rattus norvegicus Rattus norvegicus LDH 46.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 48.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 51.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 56.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 57.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 61.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 61.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 62.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 66.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 67.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 69.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 70.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 72.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 72.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 73.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 76.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 78.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 78.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 81.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 82.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 84.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 85.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 85.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 86.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 86.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 88.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 89.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 90.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 98.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 98.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 99.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 114.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 183.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 208.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 570.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9910.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11212.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12758.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 17514.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 65.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 67.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 69.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 69.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 71.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 71.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 71.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 72.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 72.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 74.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 74.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 74.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 79.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 85.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Max/average nan None 10.1021/jm00095a023
Rattus norvegicus Rattus norvegicus Max change in blood pressure -71.0 mmHg 10.1021/jm00163a037
Rattus norvegicus Rattus norvegicus Max change in blood pressure -68.0 mmHg 10.1021/jm00163a037
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 13.0 % 10.1021/jm00161a011
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 13.0 mmHg 10.1021/jm00375a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 20.0 mmHg 10.1021/jm00365a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 20.0 mmHg 10.1021/jm00375a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 27.0 % 10.1021/jm00161a011
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 30.0 mmHg 10.1021/jm00375a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 33.0 mmHg 10.1021/jm00365a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 33.0 mmHg 10.1021/jm00375a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 36.0 % 10.1021/jm00161a011
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 51.0 mmHg 10.1021/jm00365a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 51.0 mmHg 10.1021/jm00375a007
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 52.0 mmHg 10.1021/jm00398a023
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 62.0 mmHg 10.1021/jm00375a007
Rattus norvegicus Rattus norvegicus Max SBP -68.0 mmHg 10.1021/jm00378a039
Rattus norvegicus Rattus norvegicus MCH 20.2 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.4 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.5 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.6 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.7 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.8 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.9 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.0 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.1 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.2 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.3 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 23.23 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.4 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.67 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.63 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 32.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 367700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 377300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 381000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 382700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.3 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.4 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.1 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.3 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 64.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 64.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 64.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 64.3 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 64.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 65.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 65.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 65.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 66.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MED 3.5 mg kg-1 10.1016/j.bmcl.2005.11.043
Rattus norvegicus Rattus norvegicus MONO 172.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 175.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 196.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 448.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 4.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 4.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 4.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus mortality 33.3 % 10.1016/j.ejmech.2013.12.001
Rattus norvegicus Rattus norvegicus NEUTLE 6.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 14.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 14.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 20.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 21.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 21.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 21.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 21.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 23.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 23.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 24.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 26.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 27.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 29.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTSG 1148.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1213.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1358.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1590.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 56.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 57.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 58.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 61.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 64.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 67.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 68.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 70.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 71.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 73.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 74.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 77.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 83.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 86.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 90.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 92.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 95.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 96.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 97.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 100.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 102.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 107.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 108.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 110.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 111.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 117.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 133.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOSLPD 1230.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1264.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1282.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1290.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1306.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1320.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1328.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1336.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1350.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1354.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1398.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1412.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1414.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1440.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1460.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1482.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1496.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1500.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1504.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1520.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1524.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1544.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1564.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1568.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1588.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1592.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1610.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1616.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1620.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1138000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1155000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1176000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1178000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1184000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1200000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1203000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1222000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1229000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1233000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1236000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1237000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1238000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1240000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1242000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1251000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1265000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1277000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1281000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1289000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1307000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1331000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1336000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1344000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1358330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1423000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1426000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1508330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1555000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 3.7 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.9 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.1 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.3 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.5 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.7 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 5.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 5.1 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 5.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 5.24 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.3 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 5.74 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.88 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.57 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 52000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 53000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 54000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 55000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 56000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 65000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PT 13.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 13.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 13.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 13.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 5200000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6060000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6108000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6130000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6200000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6230000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6258000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6260000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6264000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6290000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6290000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6308000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6320000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6324000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6348000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6370000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6412000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6414000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6438000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6564000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6580000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6596000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6602000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6710000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6832000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6880000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6972000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7012000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7190000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7202000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Reduction 33.0 % 10.1016/S0960-894X(01)80810-6
Rattus norvegicus Rattus norvegicus RETIRBC 4.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 8.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 8.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 9.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 9.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 9.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 9.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 9.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 9.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 10.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 10.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SBP change 35.0 % 10.1021/jm00091a008
Rattus norvegicus Rattus norvegicus SODIUM 134.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 134.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 135.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 135.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 136.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 136.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 137.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 138.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 144.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 144.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 144.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 144.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 145.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 145.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 145.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 146.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 147.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 148.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus TERMBW 193.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 197.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 197.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 197.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 198.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 201.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 202.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 203.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 203.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 204.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 205.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 205.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 206.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 206.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 206.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 207.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 213.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 223.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 223.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 227.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 238.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 254.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 261.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 262.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 309.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 319.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 320.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 322.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 378.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 380.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 388.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 416.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TIME 5.042e-06 hr 10.1007/s00044-011-9700-7
Rattus norvegicus Rattus norvegicus TIME 1.264e-05 hr 10.1007/s00044-011-9700-7
Rattus norvegicus Rattus norvegicus TIME 1.695e-05 hr 10.1007/s00044-011-9700-7
Rattus norvegicus Rattus norvegicus TIME 5.961e-05 hr 10.1007/s00044-011-9700-7
Rattus norvegicus Rattus norvegicus TIME 0.001944 hr 10.1016/j.ejmech.2013.12.001
Rattus norvegicus Rattus norvegicus TIME 0.05972 hr 10.1016/j.ejmech.2013.06.006
Rattus norvegicus Rattus norvegicus TIME 0.05972 hr 10.1016/j.ejmech.2013.12.001
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus TRIG 164.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 184.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 194.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 208.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 222.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 270.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 282.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 316.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 336.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 412.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 424.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 464.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 540.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 560.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 626.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 706.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 878.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 934.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 942.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 988.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1018.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1020.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1092.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1118.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1140.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1154.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1158.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1178.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1268.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1508.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1752.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus UI 0.54 None 10.1016/j.bmc.2015.09.009
Rattus norvegicus Rattus norvegicus URATE 16.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 20.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 6550.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8580.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8720.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8790.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9210.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9460.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9470.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9490.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9590.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9600.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9630.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9640.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9720.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9750.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9950.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10030.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10100.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10190.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10560.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10810.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11080.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11270.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11310.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11340.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11390.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11670.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11710.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12180.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12710.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14930.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 18900.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WEIGHT 0.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 0.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 6.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 7.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 7.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 7.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 7.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 7.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 12.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 12.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 14.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 17.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 17.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus TGF-beta receptor type-1 Inhibition nan % 10.1021/acs.jmedchem.9b00708
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 29934.9 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 37685.8 nM None
Rattus norvegicus Thromboxane-A synthase IC50 10000.0 nM 10.1021/jm00072a017
Rattus norvegicus Trachea EC50 6500.0 nM 10.1016/j.bmcl.2016.03.001
Rattus norvegicus Trachea Kd 6025.6 nM 10.1016/j.bmcl.2016.03.001
Rattus norvegicus Voltage-gated L-type calcium channel Activity 72.3 % 10.1016/j.ejmech.2019.02.075
Rattus norvegicus Voltage-gated L-type calcium channel Activity 95.7 % 10.1016/j.ejmech.2019.02.075
Rattus norvegicus Voltage-gated L-type calcium channel Block 66.7 % 10.1021/jm980623b
Rattus norvegicus Voltage-gated L-type calcium channel Blockage 67.0 % 10.1021/jm031109v
Rattus norvegicus Voltage-gated L-type calcium channel EC50 12.0 nM 10.1016/j.bmc.2012.04.057
Rattus norvegicus Voltage-gated L-type calcium channel IC50 1.65 nM 10.1021/jm00403a030
Rattus norvegicus Voltage-gated L-type calcium channel IC50 2.0 nM 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel IC50 2.53 nM 10.1021/jm00130a029
Rattus norvegicus Voltage-gated L-type calcium channel IC50 2.57 nM 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel IC50 27.5 nM 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel IC50 27.54 nM 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel IC50 57.7 nM 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 0.0 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 8.71 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 28.88 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 39.5 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 50.0 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 55.7 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 68.0 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 78.3 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 83.63 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition 99.47 % 10.1007/s00044-011-9600-x
Rattus norvegicus Voltage-gated L-type calcium channel Ki 4.65 nM 10.1021/jm00162a013
Rattus norvegicus Voltage-gated L-type calcium channel Selectivity 8.0 None 10.1021/jm00123a009
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 340.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit IC50 1.42 nM 10.1021/jm500263v
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit Inhibition nan % 10.1021/jm500263v
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit Ki 3.5 nM 10.1021/jm00075a034
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit Selectivity index 8.0 None 10.1021/jm00130a026
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1D subunit IC50 2.7 nM 10.1021/jm9803267
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1D subunit Inhibition 46.0 % 10.1016/j.bmc.2010.03.038
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1D subunit Ki 1.2 nM 10.1021/jm9803267
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 0.0 mm 10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 14581.0 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -13.53 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 70.35 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -1.74 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.0 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.17 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.2063 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Inhibition 16.67 % 10.6019/CHEMBL4513141
Sus scrofa Sus scrofa IC50 3.6 nM 10.1021/jm960270l
Toxoplasma gondii Toxoplasma gondii IC50 nan None 10.1016/j.bmc.2010.01.068
Trichomonas vaginalis Trichomonas vaginalis IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei 6-phospho-1-fructokinase Potency 849.2 nM None
Trypanosoma brucei Trypanosoma brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei (strain 927/4 GUTat10.1) Putative uncharacterized protein Potency 19952.6 nM None
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma cruzi Trypanosoma cruzi IC50 101750.0 nM 10.1016/j.bmc.2010.09.015
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1016/j.bmc.2010.01.068
None ADMET Activity nan None 10.1016/j.bmc.2010.09.015
None ADMET Activity nan None 10.1124/dmd.112.050054
None ADMET CL 4.5 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 7.0 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 7.3 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 8.4 mL.min-1.kg-1 10.1021/jm000407e
None ADMET CL 10.0 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 12.3 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 22.39 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 28.7 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
None ADMET CL 150.0 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET CL 150.0 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 196.0 mL.min-1.kg-1 10.1124/dmd.111.042309
None ADMET Delta Gsolv -14.2 kCal mol-1 10.1021/jm981114c
None ADMET Delta Gsolv -14.12 kCal mol-1 10.1021/jm981114c
None ADMET delta logD 0.0 None 10.1021/jm0000564
None ADMET Drug metabolism 17.0 % 10.1016/j.bmcl.2012.07.032
None ADMET EFTPC 5.4 nM 10.1093/cvr/cvr044
None ADMET eLog D 2.84 None 10.1021/jm0200409
None ADMET F 79.0 % 10.1021/jm0000564
None ADMET Fraction ionised 0.0 None 10.1021/jm0200409
None ADMET Fu 0.023 None 10.1021/jm0200409
None ADMET Fu 0.04 None 10.1021/jm0200409
None ADMET Fu 0.04 None 10.1021/jm030408h
None ADMET Fu 0.068 None 10.1124/dmd.111.042309
None ADMET IC50 500000.0 nM 10.1124/dmd.112.050054
None ADMET Log k'w 2.46 None 10.1021/jm0000822
None ADMET MRT 1.8 hr 10.1124/dmd.108.020479
None ADMET Partition coefficient 3000.0 None 10.1021/jm00107a001
None ADMET PPB 92.64 % 10.6019/CHEMBL3301361
None ADMET PPB 96.17 % 10.6019/CHEMBL3301361
None ADMET PPB 99.77 % 10.6019/CHEMBL3301361
None ADMET T1/2 0.6 hr 10.1021/jm00168a041
None ADMET T1/2 1.9 hr 10.1021/jm000407e
None ADMET T1/2 1.9 hr 10.1124/dmd.108.020479
None ADMET Vd 1.0 L.kg-1 10.1021/jm000407e
None ADMET Vdss 0.13 mL/min/kg 10.1124/dmd.105.006619
None ADMET Vdss 0.5 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 0.78 L.kg-1 10.1021/jm0200409
None ADMET Vdss 0.78 L.kg-1 10.1021/jm030408h
None ADMET Vdss 0.78 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 0.79 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 1.15 L.kg-1 10.1124/dmd.105.006619
None Calvarial osteoblast EC50 1540.0 nM 10.1021/jm301281e
None Calvarial osteoblast Emax 10.0 nM 10.1021/jm301281e
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 0.3 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 2.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.1 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity LTKB_BD DILI severity score 3.0 None 10.1016/j.drudis.2011.05.007
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 0.6 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 0.4 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Lipid bilayer Activity nan None 10.1016/j.ejmech.2011.05.022
None Molecular identity unknown Potency 42163.2 nM None
None Molecular identity unknown Potency 56234.1 nM None
None NON-PROTEIN TARGET Activity 85.0 % 10.1021/jm301839q
None NON-PROTEIN TARGET Activity 97.0 % 10.1021/jm301839q
None NON-PROTEIN TARGET Activity nan None 10.1021/jm301281e
None NON-PROTEIN TARGET EC50 39.0 nM 10.1021/jm200199r
None NON-PROTEIN TARGET EC50 39.0 nM 10.1021/jm301839q
None NON-PROTEIN TARGET EC50 260.0 nM 10.1021/jm200199r
None NON-PROTEIN TARGET EC50 260.0 nM 10.1021/jm301839q
None NON-PROTEIN TARGET Fu 0.044 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.949 None 10.1124/dmd.111.042309
None NON-PROTEIN TARGET Hepatotoxicity (acute) 4.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 6.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 12.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 96.0 nM 10.1021/jm200199r
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.01.068
None NON-PROTEIN TARGET Inhibition 62.0 % 10.1021/jm200199r
None NON-PROTEIN TARGET Inhibition 85.0 % 10.1021/jm200199r
None NON-PROTEIN TARGET Inhibition 97.0 % 10.1021/jm200199r
None NON-PROTEIN TARGET Inhibition nan % 10.1016/j.ejmech.2011.05.022
None NON-PROTEIN TARGET Potency 8912.5 nM None
None NON-PROTEIN TARGET Potency 11220.2 nM None
None NON-PROTEIN TARGET Potency 12589.3 nM None
None NON-PROTEIN TARGET Potency 15848.9 nM None
None NON-PROTEIN TARGET Ratio 0.036 None 10.1021/jm00167a033
None NON-PROTEIN TARGET Ratio 0.135 None 10.1021/jm00167a033
None NON-PROTEIN TARGET Ratio 1.0 None 10.1021/jm960270l
None No relevant target Activity nan None 10.1021/acs.jmedchem.9b00937
None No relevant target CLogP 2.21 None 10.1021/jm9604989
None No relevant target Drug degradation 100.0 % 10.1016/j.ejmech.2022.114374
None No relevant target Drug degradation nan None 10.1016/j.ejmech.2022.114374
None No relevant target LogD 0.42 None 10.1021/jm0000564
None No relevant target LogD 3.13 None 10.1021/acs.jmedchem.2c01079
None No relevant target LogD 3.17 None 10.1021/jm0100990
None No relevant target LogD 3.2 None 10.1021/jm000407e
None No relevant target LogD7.4 3.29 None 10.6019/CHEMBL3301361
None No relevant target Log Kmemb -0.1 None 10.1021/jm0309001
None No relevant target LogP 2.06 None 10.1021/jm9604989
None No relevant target LogP 2.4 None 10.1016/j.ejmech.2010.07.027
None No relevant target LogP 2.85 None 10.1021/jm0000822
None No relevant target LogP 2.9 None 10.1021/acs.jmedchem.5b00201
None No relevant target LogP 3.17 None 10.1021/jm0000822
None No relevant target LogP 3.3 None 10.1124/dmd.111.042309
None No relevant target LogP 3.86 None 10.1016/j.bmc.2015.09.009
None No relevant target Log S -4.76 None 10.1016/s0960-894x(00)00172-4
None No relevant target Log S -4.76 None 10.1021/acs.jmedchem.5b01448
None No relevant target Log S -4.18 None 10.1016/j.ejmech.2012.07.017
None No relevant target -log(solubility) 4.44 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 4.55 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 4.64 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 4.87 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 4.94 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 5.76 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 5.84 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 6.24 None 10.1016/j.bmcl.2015.02.013
None No relevant target Peff nan None 10.1021/acs.jmedchem.9b00937
None No relevant target pKa 1.0 None 10.1124/dmd.111.042309
None No relevant target pKa nan None 10.1021/jm0000564
None No relevant target pKa nan None 10.1021/jm030408h
None No relevant target Solubility 20900.0 nM 10.6019/CHEMBL3301361
None No relevant target Solubility 250000.0 nM 10.1016/j.ejmech.2014.06.078
None No relevant target T1/2 0.06667 hr 10.1016/j.ejmech.2022.114374
None Spermatozoa Activity nan None 10.1016/j.ejmech.2011.05.022
None Unchecked Ac50 35.48 uM None
None Unchecked Ac50 39.81 uM None
None Unchecked AC50 35481.3 nM None
None Unchecked AC50 39810.7 nM None
None Unchecked Activity 25.0 % 10.1021/jm301281e
None Unchecked Activity 70.0 % 10.1021/jm070681+
None Unchecked Activity 82.0 % 10.1021/jm070681+
None Unchecked Activity 85.0 % 10.1021/jm070681+
None Unchecked Activity 90.0 % 10.1021/np50094a001
None Unchecked Activity 97.0 % 10.1021/jm070681+
None Unchecked Activity nan None 10.1016/j.ejmech.2008.10.008
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1021/acs.jmedchem.5b01117
None Unchecked Activity nan None 10.1021/np100213a
None Unchecked Anticonvulsant activity nan None 10.1016/s0960-894x(03)00535-3
None Unchecked APDc 57.63 None 10.6019/CHEMBL4295262
None Unchecked APDc 59.3 None 10.6019/CHEMBL4295262
None Unchecked APDc nan None 10.6019/CHEMBL4295262
None Unchecked EC30 0.025 uM 10.1021/jm070681+
None Unchecked EC50 1.0 nM 10.1016/j.bmc.2008.06.039
None Unchecked EC50 260.0 nM 10.1021/jm070681+
None Unchecked EC50 1450.0 nM 10.1021/jm301281e
None Unchecked Emax 10.0 nM 10.1021/jm301281e
None Unchecked Emax 94.02 % 10.1016/j.ejmech.2008.10.008
None Unchecked FICI 0.017 None 10.1021/acs.jmedchem.7b01413
None Unchecked FPDc 16.23 None 10.6019/CHEMBL4295262
None Unchecked FPDc 17.1 None 10.6019/CHEMBL4295262
None Unchecked FPDc 21.76 None 10.6019/CHEMBL4295262
None Unchecked FPDc 21.94 None 10.6019/CHEMBL4295262
None Unchecked FPDc 24.94 None 10.6019/CHEMBL4295262
None Unchecked FPDc 43.95 None 10.6019/CHEMBL4295262
None Unchecked FPDc 50.88 None 10.6019/CHEMBL4295262
None Unchecked FPDc 51.56 None 10.6019/CHEMBL4295262
None Unchecked FPDc 70.54 None 10.6019/CHEMBL4295262
None Unchecked FPDc 73.26 None 10.6019/CHEMBL4295262
None Unchecked FPDc nan None 10.6019/CHEMBL4295262
None Unchecked FPD measurement 16.23 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 24.94 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 43.95 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 50.88 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 57.63 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 59.3 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement nan None 10.6019/CHEMBL4295262
None Unchecked Hepatotoxicity (acute) 14.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 7.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC15 2.02 nM 10.1016/j.bmc.2013.09.033
None Unchecked IC30 9.27 nM 10.1016/j.bmc.2013.09.033
None Unchecked IC50 0.8318 nM 10.1021/jm00119a009
None Unchecked IC50 1.07 nM 10.1016/j.bmc.2008.12.070
None Unchecked IC50 1.5 nM 10.1021/jm070681+
None Unchecked IC50 1.5 nM 10.1021/jm200199r
None Unchecked IC50 2.5 nM 10.1021/jm00062a015
None Unchecked IC50 2.5 nM 10.1021/jm00084a002
None Unchecked IC50 3.6 nM 10.1021/jm070681+
None Unchecked IC50 4.0 nM 10.1021/acs.jmedchem.7b00969
None Unchecked IC50 5.1 nM 10.1021/jm301839q
None Unchecked IC50 5.7 nM 10.1021/jm301839q
None Unchecked IC50 6.1 nM 10.1021/jm301839q
None Unchecked IC50 8.67 nM None
None Unchecked IC50 9.0 nM 10.1021/acs.jmedchem.5b01117
None Unchecked IC50 10.0 nM 10.1016/j.ejmech.2012.05.017
None Unchecked IC50 45.0 nM 10.1021/jm070681+
None Unchecked IC50 48.0 nM None
None Unchecked IC50 60.0 nM 10.1016/j.bmcl.2008.10.099
None Unchecked IC50 86.0 nM 10.1021/jm301839q
None Unchecked IC50 878.0 nM None
None Unchecked IC50 2340.0 nM 10.1016/j.bmc.2015.09.009
None Unchecked IC50 3779.0 nM None
None Unchecked IC50 6500.0 nM 10.1021/acs.jmedchem.2c01079
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2008.10.002
None Unchecked IC50 23832.0 nM None
None Unchecked IC50 44158.0 nM None
None Unchecked IC50 100000.0 nM 10.1039/C9MD00108E
None Unchecked IC50 342700.0 nM 10.1016/j.ejmech.2022.114144
None Unchecked IC50 342700.0 nM 10.1039/d1md00274k
None Unchecked IC50 nan None None
None Unchecked Inhibition 47.9 % 10.1016/j.ejmech.2014.04.075
None Unchecked Inhibition 48.1 % 10.1016/j.bmc.2007.09.041
None Unchecked Inhibition 50.0 % 10.1021/np50094a001
None Unchecked Inhibition 66.0 % 10.1021/jm301144g
None Unchecked Inhibition 70.0 % 10.1021/jm200199r
None Unchecked Inhibition nan % 10.1016/j.bmcl.2014.01.014
None Unchecked Inhibition nan % 10.1016/j.ejmech.2014.06.035
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Kapp 0.08434 /M 10.1016/j.ejmech.2011.05.022
None Unchecked Kd 2900.0 nM 10.1021/jm200199r
None Unchecked Ki 0.53 nM 10.1016/S0960-894X(01)80771-X
None Unchecked Ki 0.53 nM 10.1016/S0960-894X(01)81229-4
None Unchecked Ki 1.479 nM 10.1021/jm070681+
None Unchecked Ki 1.5 nM 10.1021/jm301839q
None Unchecked Ki 1.6 nM 10.1021/np50094a001
None Unchecked Ki 1.9 nM 10.1021/jm301839q
None Unchecked Ki 2.0 nM 10.1021/jm301839q
None Unchecked Ki 7.707 nM None
None Unchecked Ki 31.0 nM None
None Unchecked Ki 32.0 nM 10.1021/jm301839q
None Unchecked Ki 853.0 nM None
None Unchecked Ki 3388.0 nM None
None Unchecked Ki 8153.0 nM None
None Unchecked Ki 66600.0 nM 10.1016/j.ejmech.2022.114144
None Unchecked Ki nan None None
None Unchecked logIC50 1.57 None 10.1016/j.bmc.2013.11.049
None Unchecked %max 72.0 % 10.1021/jm301839q
None Unchecked %max 75.0 % 10.1021/jm301839q
None Unchecked %max 80.0 % 10.1021/jm301839q
None Unchecked %max 92.0 % 10.1021/jm301839q
None Unchecked pD2 6.92 None 10.1016/j.ejmech.2008.10.008
None Unchecked Potency 9.5 nM None
None Unchecked Potency 1258.9 nM None
None Unchecked Potency 3162.3 nM None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 3662.6 nM None
None Unchecked Potency 5623.4 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 10692.8 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 14581.0 nM None
None Unchecked Potency 15848.9 nM None
None Unchecked Potency 18356.4 nM None
None Unchecked Potency 22387.2 nM None
None Unchecked Potency 23109.3 nM None
None Unchecked Potency 23778.1 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Potency 29081.0 nM None
None Unchecked Potency 29092.9 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency 39810.7 nM None
None Unchecked Potency 50118.7 nM None
None Unchecked Ratio 0.002 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.009 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.88 None 10.1016/j.bmc.2012.08.040
None Unchecked Ratio IC50 30.0 None 10.1016/j.bmcl.2012.10.010
None Unchecked Ratio IC50 950.7 None 10.1021/jm500263v
None Unchecked Selectivity index 8.0 None 10.1021/jm00105a004
None Unchecked Selectivity index 8.0 None 10.1021/jm00168a041
None Unchecked Selectivity index 39.0 None 10.1021/jm00091a008
None Unchecked Selectivity Index 4.21 None 10.1016/j.bmc.2010.09.015
None Unchecked Selectivity Index 5.78 None 10.1016/j.bmc.2010.09.015
None Unchecked Selectivity ratio 0.67 None 10.1016/j.bmc.2010.03.038

Metabolism Information