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name Structure Reference Source Properties Activities Metabolism

tetraethylazanium

AlkaPlorer ID: AK319491

Synonym: None

IUPAC Name: tetraethylazanium

Structure

SMILES: CC[N+](CC)(CC)CC

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InChI: InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1

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InChIKey: CBXCPBUEXACCNR-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Allium sativum Allium Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 130.255

TPSA？: 0.0

MolLogP？: 1.8828

Number of H-Donors: 0

Number of H-Acceptors: 0

RingCount: 0

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Equilibrative nucleoside transporter 4 Activity -11.7 nanoampere 10.1124/dmd.111.042432
Homo sapiens Equilibrative nucleoside transporter 4 Activity -0.627 nanoampere 10.1124/dmd.111.042432
Homo sapiens HEK293 Potency 1457.5 nM None
Homo sapiens Multidrug and toxin extrusion protein 1 Activity nan None 10.1038/nrd3028
Homo sapiens Multidrug and toxin extrusion protein 2 Activity nan None 10.1038/nrd3028
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 11220.2 nM None
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/s0928-0987(00)00097-x
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens Potassium channel subfamily K member 9 Inhibition 6.1 % 10.1021/acs.jmedchem.9b00248
Homo sapiens Solute carrier family 22 member 1 Activity 168.0 uM 10.1124/mol.63.3.489
Homo sapiens Solute carrier family 22 member 1 Activity nan None 10.1038/nrd3028
Homo sapiens Solute carrier family 22 member 1 Activity nan None 10.1089/dna.1997.16.871
Homo sapiens Solute carrier family 22 member 1 Inhibition nan % 10.1124/dmd.110.037960
Homo sapiens Solute carrier family 22 member 1 Ki 158000.0 nM None
Homo sapiens Solute carrier family 22 member 1 Ki 161000.0 nM None
Homo sapiens Solute carrier family 22 member 1 Ki 163000.0 nM 10.1124/mol.51.6.913
Homo sapiens Solute carrier family 22 member 1 Km 2320.0 nM 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Km 229000.0 nM None
Homo sapiens Solute carrier family 22 member 1 Vmax 696.0 RFU/min 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 11 Activity nan None 10.1074/jbc.275.6.4507
Homo sapiens Solute carrier family 22 member 2 Activity nan None 10.1038/nrd3028
Homo sapiens Solute carrier family 22 member 2 Activity nan None 10.1074/jbc.m108472200
Homo sapiens Solute carrier family 22 member 2 IC50 156000.0 nM 10.1023/a:1019870831174
Homo sapiens Solute carrier family 22 member 2 Km 31000.0 nM 10.1089/dna.1997.16.871
Homo sapiens Solute carrier family 22 member 2 Km 63000.0 nM 10.1097/01.asn.0000019413.78751.46
Homo sapiens Solute carrier family 22 member 2 Km 76000.0 nM 10.1089/dna.1997.16.871
Homo sapiens Solute carrier family 22 member 2 Km 431000.0 nM 10.1097/01.asn.0000019413.78751.46
Homo sapiens Solute carrier family 22 member 3 Activity nan None 10.1152/ajprenal.2000.279.3.f449
Homo sapiens Solute carrier family 22 member 3 IC50 10300000.0 nM 10.1007/s002100000335
Homo sapiens Solute carrier family 22 member 3 Ki 1372000.0 nM 10.1152/ajprenal.2000.279.3.f449
Homo sapiens Solute carrier family 22 member 4 Km 436000.0 nM None
Homo sapiens Solute carrier family 22 member 5 Activity 40.0 % None
Homo sapiens Solute carrier family 22 member 5 Activity 53.6 % None
Homo sapiens Solute carrier family 22 member 5 Activity nan None None
Homo sapiens Solute carrier family 22 member 6 Activity nan None 10.1124/mol.56.3.570
Homo sapiens Solute carrier family 22 member 8 Activity nan None 10.1006/bbrc.1998.9978
Homo sapiens Solute carrier family 22 member 8 Activity nan None 10.1124/mol.59.5.1277
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 25.9 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 4.9 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 6.7 % 10.1021/jm300212s
Homo sapiens T-cell line IC50 1000.0 nM 10.1016/S0960-894X(97)00163-7
Homo sapiens Thyroid stimulating hormone receptor Potency 3981.1 nM None
Homo sapiens Voltage-gated potassium channel subunit Kv1.1 IC50 30000.0 nM 10.1021/acs.jmedchem.6b01262
Mus musculus Choline transporter Ki 260015.96 nM 10.1016/j.bmcl.2010.06.090
Mus musculus Mus musculus AUC 2410.0 ng.hr.mL-1 10.1124/dmd.112.044875
Mus musculus Mus musculus AUC 2840.0 ng.hr.mL-1 10.1124/dmd.112.044875
Mus musculus Mus musculus AUC 9100.0 ng.hr.mL-1 10.1124/dmd.112.044875
Mus musculus Mus musculus AUC 9840.0 ng.hr.mL-1 10.1124/dmd.112.044875
Mus musculus Mus musculus C0 22.7 ug ml-1 10.1124/dmd.112.044875
Mus musculus Mus musculus C0 67.4 ug ml-1 10.1124/dmd.112.044875
Mus musculus Mus musculus CL 0.08 ml/min 10.1124/dmd.112.044875
Mus musculus Mus musculus CL 0.09 ml/min 10.1124/dmd.112.044875
Mus musculus Mus musculus CL 0.12 ml/min 10.1124/dmd.112.044875
Mus musculus Mus musculus CL 0.19 ml/min 10.1124/dmd.112.044875
Mus musculus Mus musculus CL 16.9 mL.min-1.kg-1 10.1124/dmd.112.044875
Mus musculus Mus musculus CL 58.7 mL.min-1.kg-1 10.1124/dmd.112.044875
Mus musculus Mus musculus Drug recovery 62.0 % 10.1124/dmd.112.044875
Mus musculus Mus musculus Drug recovery 95.0 % 10.1124/dmd.112.044875
Mus musculus Mus musculus T1/2 0.2 hr 10.1124/dmd.112.044875
Mus musculus Mus musculus T1/2 0.31 hr 10.1124/dmd.112.044875
Mus musculus Mus musculus Vdss 0.318 L.kg-1 10.1124/dmd.112.044875
Mus musculus Mus musculus Vdss 1.52 L.kg-1 10.1124/dmd.112.044875
Mus musculus Solute carrier family 22 member 1 Activity nan None 10.1128/mcb.21.16.5471-5477.2001
Mus musculus Solute carrier family 22 member 1 IC50 540.0 nM 10.1016/s0006-291x(02)00926-9
Mus musculus Solute carrier family 22 member 1 Ki 128000.0 nM None
Mus musculus Solute carrier family 22 member 1 Km 38000.0 nM 10.1002/hep.510290530
Mus musculus Solute carrier family 22 member 2 IC50 3500.0 nM 10.1016/s0006-291x(02)00926-9
Mus musculus Solute carrier family 22 member 2 Km 35700.0 nM 10.1016/s0006-291x(02)00926-9
Mus musculus Solute carrier family 22 member 3 Activity nan None 10.1152/ajprenal.2000.279.3.f449
Mus musculus Solute carrier family 22 member 3 Km 1900000.0 nM 10.1152/ajprenal.2000.279.3.f449
Mus musculus Solute carrier family 22 member 4 Km 452000.0 nM 10.1074/jbc.m005340200
Mus musculus Solute carrier family 22 member 5 Activity 15.4 % 10.1124/mol.59.2.358
Mus musculus Solute carrier family 22 member 5 Km 216000.0 nM 10.1074/jbc.m005340200
Rattus norvegicus Brain Compound recovery nan None 10.1124/dmd.110.035998
Rattus norvegicus Brain Fu 1.0 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Kp 8.95 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Vd 9.0 L.kg-1 10.1124/dmd.110.035998
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 3162.3 nM None
Rattus norvegicus Solute carrier family 22 member 1 Activity nan None 10.1038/sj.bjp.0702065
Rattus norvegicus Solute carrier family 22 member 1 Ki 46600.0 nM None
Rattus norvegicus Solute carrier family 22 member 1 Ki 100000.0 nM None
Rattus norvegicus Solute carrier family 22 member 1 Ki 286000.0 nM 10.1016/s0006-2952(00)00334-8
Rattus norvegicus Solute carrier family 22 member 1 Km 35000.0 nM 10.1074/jbc.271.51.32599
Rattus norvegicus Solute carrier family 22 member 1 Km 38000.0 nM None
Rattus norvegicus Solute carrier family 22 member 1 Km 42000.0 nM 10.1074/jbc.272.26.16548
Rattus norvegicus Solute carrier family 22 member 1 Km 95000.0 nM 10.1038/372549a0
Rattus norvegicus Solute carrier family 22 member 1 Km 129000.0 nM 10.1124/mol.56.6.1254
Rattus norvegicus Solute carrier family 22 member 1 Km 251000.0 nM 10.1016/s0006-2952(00)00334-8
Rattus norvegicus Solute carrier family 22 member 2 Activity nan None 10.1124/mol.56.1.1
Rattus norvegicus Solute carrier family 22 member 2 Ki 52200.0 nM None
Rattus norvegicus Solute carrier family 22 member 2 Km 33800.0 nM 10.1016/s0005-2736(99)00005-x
Rattus norvegicus Solute carrier family 22 member 2 Km 45000.0 nM None
Rattus norvegicus Solute carrier family 22 member 2 Km 48000.0 nM 10.1152/ajprenal.1999.277.6.f890
Rattus norvegicus Solute carrier family 22 member 2 Km 91000.0 nM 10.1152/ajprenal.2001.281.3.f454
Rattus norvegicus Solute carrier family 22 member 2 Km 141000.0 nM 10.1093/toxsci/47.2.181
Rattus norvegicus Solute carrier family 22 member 2 Km 160000.0 nM 10.1074/jbc.m004645200
Rattus norvegicus Solute carrier family 22 member 2 Km 393000.0 nM 10.1152/ajprenal.1999.277.6.f890
Rattus norvegicus Solute carrier family 22 member 3 Activity 41.0 % 10.1074/jbc.273.26.15971
Rattus norvegicus Solute carrier family 22 member 3 Km 2500000.0 nM 10.1074/jbc.273.26.15971
Rattus norvegicus Solute carrier family 22 member 3 Km 6200000.0 nM 10.1074/jbc.273.26.15971
Rattus norvegicus Solute carrier family 22 member 4 Activity nan None 10.1016/s0005-2736(00)00189-9
Rattus norvegicus Solute carrier family 22 member 4 IC50 1000000.0 nM 10.1016/s0005-2736(00)00189-9
Rattus norvegicus Solute carrier family 22 member 5 Activity 4.0 % None
Rattus norvegicus Solute carrier family 22 member 5 Km 63000.0 nM None
Rattus norvegicus Solute carrier family 22 member 6 Activity nan None 10.1074/jbc.272.30.18526
Rattus norvegicus Solute carrier family 22 member 6 Activity nan None 10.1074/jbc.272.48.30088
Rattus norvegicus Solute carrier family 22 member 7 Activity nan None 10.1016/s0014-5793(98)00585-7
Rattus norvegicus Solute carrier family 22 member 8 Activity nan None 10.1074/jbc.274.19.13675
Rattus norvegicus Solute carrier organic anion transporter family member 1A1 Activity nan None 10.1007/s004240100697
Rattus norvegicus Solute carrier organic anion transporter family member 1A4 Activity nan None 10.1007/s004240100697
Rattus norvegicus Solute carrier organic anion transporter family member 1A5 Activity nan None 10.1007/s004240100697
Rattus norvegicus Solute carrier organic anion transporter family member 1B2 Activity nan None 10.1007/s004240100697
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 37685.8 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 33807.8 nM None
None ADMET Drug excretion 30.0 % 10.1124/dmd.112.044875
None ADMET Drug excretion 35.0 % 10.1124/dmd.112.044875
None Unchecked IC50 7900000.0 nM 10.1016/j.bmcl.2004.05.031
None Unchecked Potency 29081.0 nM None

Metabolism Information