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name Structure Reference Source Properties Activities Metabolism

Ifenprodil

AlkaPlorer ID: AK319896

Synonym: None

IUPAC Name: 4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol

Structure

SMILES: CC(C(O)C1=CC=C(O)C=C1)N1CCC(CC2=CC=CC=C2)CC1

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InChI: InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3

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InChIKey: UYNVMODNBIQBMV-UHFFFAOYSA-N

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Reference

PubChem CID: 3689

CAS: 23210-56-2

NPASS: NPC307020

COCONUT: CNP0340849.5

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 325.45200000000006

TPSA？: 43.7

MolLogP？: 3.7688000000000033

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Serotonin 2a (5-HT2a) receptor IC50 610.0 nM 10.1021/jm00114a018
Cavia porcellus 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Ki 2.71 nM 10.1021/jm021014d
Cavia porcellus 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Ki 4.7 nM 10.1021/jm050654o
Cavia porcellus 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Ki 10.2 nM 10.1021/jm9007505
Cavia porcellus 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Ki 15.0 nM 10.1016/j.bmc.2011.10.023
Cavia porcellus 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Ki 16.4 nM 10.1021/jm800965b
Cavia porcellus 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Ki 19.8 nM 10.1021/jm070373b
Cavia porcellus Sigma-1 receptor Ki 1.02 nM 10.1016/j.bmc.2013.11.014
Cavia porcellus Sigma-1 receptor Ki 2.0 nM 10.1021/jm800965b
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.bmc.2010.09.026
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.bmc.2014.10.004
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.bmc.2017.12.010
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.bmc.2019.115146
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.bmc.2019.115245
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.ejmech.2017.06.068
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.ejmech.2017.12.054
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.ejmech.2018.08.003
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.ejmech.2018.09.010
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1016/j.ejmech.2020.112138
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1021/acs.jmedchem.2c01003
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1021/acsmedchemlett.9b00524
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1039/C6MD00621C
Cavia porcellus Sigma-1 receptor Ki 125.0 nM 10.1039/C8MD00545A
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 450.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 3800.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 440.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 890.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ataxin-2 Potency 28183.8 nM None
Homo sapiens Ataxin-2 Potency 31622.8 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 12990.0 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 18348.9 nM None
Homo sapiens Beta-1 adrenergic receptor AC50 23000.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-glucocerebrosidase Potency 35481.3 nM None
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor Potency 281.8 nM None
Homo sapiens Dopamine D1 receptor Potency 326.4 nM None
Homo sapiens Dopamine D1 receptor Potency 11220.2 nM None
Homo sapiens Dopamine D2 receptor AC50 2700.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 1000.0 nM 10.1021/jm00114a018
Homo sapiens Dopamine D3 receptor AC50 1200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 1200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 29855.4 nM None
Homo sapiens Geminin Potency 37585.7 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A Inhibition 13.08 % 10.1016/j.ejmech.2021.113876
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A Inhibition 22.27 % 10.1016/j.ejmech.2011.03.013
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A Ratio 0.77 None 10.1016/j.bmcl.2010.07.043
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 66.0 nM 10.1016/j.ejmech.2011.03.013
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 110.0 nM 10.1016/j.bmcl.2008.04.019
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 177.4 nM 10.1016/j.ejmech.2011.03.013
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 190.0 nM 10.1016/j.bmcl.2010.07.043
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 340.0 nM 10.1016/j.ejmech.2011.03.013
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 340.0 nM 10.1021/jm3015926
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B Inhibition 0.94 % 10.1016/j.bmcl.2010.07.043
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B Inhibition 134.75 % 10.1016/j.ejmech.2021.113876
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B Ki 10.0 nM 10.1016/j.bmc.2010.09.026
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B Ki 10.0 nM 10.1016/j.ejmech.2018.08.003
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B Ratio 0.06 None 10.1016/j.bmcl.2010.07.043
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B Ratio IC50 1.0 None 10.1016/j.bmcl.2008.04.019
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 1 IC50 39500.0 nM 10.1021/acs.jmedchem.7b01640
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 IC50 13.3 nM 10.1039/C8MD00545A
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 IC50 20.0 nM 10.1016/j.bmc.2013.12.040
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 IC50 110.0 nM 10.1021/acs.jmedchem.7b01640
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Inhibition 95.0 % 10.1016/j.ejmech.2020.112138
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.0 nM 10.1016/j.bmc.2014.10.004
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.0 nM 10.1016/j.bmc.2019.115245
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.0 nM 10.1016/j.ejmech.2017.12.054
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.0 nM 10.1016/j.ejmech.2020.112138
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.0 nM 10.1021/acsmedchemlett.9b00524
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.0 nM 10.1039/C6MD00621C
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.0 nM 10.1039/C8MD00545A
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 2 Ki 10.07 nM 10.1021/acs.jmedchem.2c01003
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 3 IC50 29100.0 nM 10.1021/acs.jmedchem.7b01640
Homo sapiens Glutamate [NMDA] receptor subunit epsilon 4 IC50 75900.0 nM 10.1021/acs.jmedchem.7b01640
Homo sapiens HEK293 Potency 23099.9 nM None
Homo sapiens HERG AC50 670.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 100.0 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens Histamine H1 receptor AC50 1000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 1000.0 nM 10.1021/jm00114a018
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 631.0 nM None
Homo sapiens Ionotropic glutamate receptor NMDA 1/2C Inhibition 28.84 % 10.1016/j.ejmech.2021.113876
Homo sapiens Ionotropic glutamate receptor NMDA 1/2D Inhibition 18.09 % 10.1016/j.ejmech.2021.113876
Homo sapiens Kappa opioid receptor AC50 1000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Liver microsomes T1/2 0.08333 hr 10.1016/j.bmc.2010.09.026
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 1000.0 nM 10.1021/jm00114a018
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 2500.0 nM 10.1038/s41467-023-40064-9
Homo sapiens PC-3 Activity 10.0 % 10.1021/jm800965b
Homo sapiens PC-3 Ki 25.8 nM 10.1021/jm800965b
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 35481.3 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ras-related protein Rab-9A Potency 58047.9 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 10399.2 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 11668.1 nM None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 1300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 9600.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 2300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 280.0 nM 10.1038/s41467-023-40064-9
Homo sapiens SH-SY5Y Activity 16.4 % 10.1016/j.bmcl.2023.129213
Homo sapiens SH-SY5Y Activity 22.57 % 10.1016/j.bmcl.2023.129213
Homo sapiens SH-SY5Y Activity 35.81 % 10.1016/j.bmcl.2023.129213
Homo sapiens SH-SY5Y IC50 0.73 nM 10.1021/jm3009458
Homo sapiens SH-SY5Y Potency 31622.8 nM None
Homo sapiens Sigma opioid receptor IC50 3.9 nM 10.1021/jm00114a018
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Transthyretin Activity 9.1 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Transthyretin Activity 27.0 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Transthyretin Activity 54.0 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Transthyretin Activity 89.0 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8414.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 21136.0 nM None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Mus musculus Dopamine D1 receptor IC50 1000.0 nM 10.1021/jm00114a018
Mus musculus Glutamate [NMDA] receptor subunit epsilon 2 Activity 79.0 % 10.1021/jm301508d
Mus musculus Glutamate [NMDA] receptor subunit epsilon 2 Activity 153.0 % 10.1021/jm301508d
Mus musculus Serotonin 1a (5-HT1a) receptor IC50 238.0 nM 10.1021/jm00114a018
Plasmodium falciparum Plasmodium falciparum Potency 2133.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 19011.5 nM None
Rattus norvegicus Adrenergic receptor alpha-1 IC50 100.0 nM 10.1021/jm00114a018
Rattus norvegicus Adrenergic receptor alpha-1 IC50 110.0 nM 10.1021/jm00114a018
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate NMDA receptor IC50 263.0 nM 10.1021/jm00114a018
Rattus norvegicus Glutamate NMDA receptor Ki 143.2 nM 10.1016/j.ejmech.2021.113876
Rattus norvegicus Glutamate NMDA receptor; Grin1/Grin2b IC50 73.0 nM 10.1021/jm8002153
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 IC50 20.0 nM 10.1016/j.bmc.2013.12.040
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 IC50 20.0 nM 10.1021/jm301508d
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 IC50 20.5 nM 10.1016/j.bmc.2008.12.058
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 IC50 47.0 nM 10.1016/j.bmc.2016.02.021
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 IC50 nan None 10.1016/j.bmc.2013.12.040
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 Ki 11.0 nM 10.1016/j.bmcl.2008.04.019
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 Ki 19.0 nM 10.1016/j.bmc.2013.11.014
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 Ki 20.0 nM 10.1016/j.bmc.2010.08.053
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 Ki 29.0 nM 10.1021/jm3009458
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 Ratio 1.0 None 10.1016/j.bmcl.2008.04.019
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Liver microsomes T1/2 0.01667 hr 10.1016/j.bmc.2010.09.026
Rattus norvegicus Muscarinic acetylcholine receptor M3 IC50 1000.0 nM 10.1021/jm00114a018
Rattus norvegicus PC-12 Activity 40.3 % 10.1016/j.bmc.2023.117236
Rattus norvegicus PC-12 Activity 41.4 % 10.1016/j.bmc.2023.117236
Rattus norvegicus PC-12 Activity 46.4 % 10.1016/j.bmc.2023.117236
Rattus norvegicus PC-12 Activity 82.3 % 10.1016/j.bmc.2023.117236
Rattus norvegicus Peripheral myelin protein 22 Potency 25574.8 nM None
Rattus norvegicus Rattus norvegicus Activity 1.75 None 10.1016/j.ejmech.2021.113876
Rattus norvegicus Rattus norvegicus Activity 14.35 % 10.1016/j.ejmech.2021.113876
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.bmc.2017.12.010
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.bmc.2019.115146
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.bmc.2019.115245
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.ejmech.2017.06.068
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.ejmech.2017.12.054
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.ejmech.2018.08.003
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.ejmech.2018.09.010
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1016/j.ejmech.2020.112138
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1021/acs.jmedchem.2c01003
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1021/acsmedchemlett.9b00524
Rattus norvegicus Sigma intracellular receptor 2 Ki 98.0 nM 10.1039/C8MD00545A
Rattus norvegicus Sigma opioid receptor Ki 2.0 nM 10.1021/jm900366z
Rattus norvegicus Sigma opioid receptor Ki 4.9 nM 10.1021/jm990277d
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 16360.1 nM None
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Activity nan None 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
None ADMET T1/2 0.08333 hr 10.1016/j.bmc.2010.09.026
None ADMET TI 0.38 None 10.1021/jm00114a018
None Molecular identity unknown Activity 63.0 % 10.1038/nchembio873
None Molecular identity unknown Activity nan None 10.1038/nchembio873
None NON-PROTEIN TARGET Activity nan None 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 206.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 420.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 1990.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET IC50 3500.0 nM 10.1021/jm3015926
None Unchecked Ac50 17.78 uM None
None Unchecked Ac50 28.18 uM None
None Unchecked Ac50 39.81 uM None
None Unchecked AC50 17782.8 nM None
None Unchecked AC50 28183.8 nM None
None Unchecked AC50 39810.7 nM None
None Unchecked Activity 65.93 % 10.1016/j.ejmech.2021.113876
None Unchecked Activity 76.98 % 10.1016/j.ejmech.2021.113876
None Unchecked Activity 85.83 % 10.1016/j.ejmech.2021.113876
None Unchecked Activity nan None 10.1038/nchembio873
None Unchecked IC50 250.0 nM 10.1016/j.bmc.2019.115146
None Unchecked IC50 590.0 nM 10.1016/j.ejmech.2017.12.054
None Unchecked IC50 590.0 nM 10.1016/j.ejmech.2020.112138
None Unchecked Inhibition 87.0 % 10.1016/j.ejmech.2017.06.068
None Unchecked Inhibition nan % 10.1016/j.ejmech.2018.09.006
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ki 2.3 nM 10.1021/jm800965b
None Unchecked Ki 10.0 nM 10.1016/j.bmc.2017.12.010
None Unchecked Ki 10.0 nM 10.1016/j.bmc.2019.115146
None Unchecked Ki 10.0 nM 10.1016/j.ejmech.2017.06.068
None Unchecked Ki 10.0 nM 10.1016/j.ejmech.2018.09.010
None Unchecked Ki 18.8 nM 10.1016/j.bmc.2013.11.014
None Unchecked Ki 98.0 nM 10.1039/C6MD00621C
None Unchecked Ki 98.3 nM 10.1016/j.bmc.2010.09.026
None Unchecked Ki 98.3 nM 10.1016/j.bmc.2014.10.004
None Unchecked Ki 3080.0 nM 10.1021/jm3009458
None Unchecked Ki 10000.0 nM 10.1016/j.ejmech.2017.06.068
None Unchecked Ki nan None 10.1039/C6MD00621C
None Unchecked Potency 2818.4 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 20587.8 nM None
None Unchecked Potency 29092.9 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency 36125.4 nM None
None Unchecked Ratio 0.87 None 10.1016/j.bmcl.2010.07.043
None Unchecked Ratio IC50 200.0 None 10.1021/jm3015926
None Unchecked Ratio Ki 0.05 None 10.1016/j.bmc.2013.11.014
None Unchecked Ratio Ki 0.12 None 10.1021/jm800965b
None Unchecked Ratio Ki 0.14 None 10.1021/jm800965b
None Unchecked Ratio Ki 0.8 None 10.1016/j.ejmech.2018.09.010
None Unchecked Ratio Ki 1.27 None 10.1021/acs.jmedchem.2c01003
None Unchecked Ratio Ki 10.0 None 10.1016/j.ejmech.2017.06.068
None Unchecked Ratio Ki 13.0 None 10.1016/j.ejmech.2017.06.068

Metabolism Information