dihydroorotic acid
AlkaPlorer ID: AK320231
Synonym: None
IUPAC Name: 2,6-dioxo-1,3-diazinane-4-carboxylic acid
Structure
SMILES: O=C(O)C1CC(O)=NC(O)=N1
InChI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)
InChIKey: UFIVEPVSAGBUSI-UHFFFAOYSA-N
Reference
PubChem CID: 648
CAS: 5988-19-2
LOTUS: LTS0136421
SuperNatural Ⅲ: SN0368928-01
COCONUT: CNP0415797.2
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Homo sapiens | Homo | Hominidae | Primates | Mammalia | Chordata | Metazoa | Eukaryota |
| Saccharomyces cerevisiae | Saccharomyces | Saccharomycetaceae | Saccharomycetales | Saccharomycetes | Ascomycota | Fungi | Eukaryota |
| Mus musculus | Mus | Muridae | Rodentia | Mammalia | Chordata | Metazoa | Eukaryota |
| Escherichia coli | Escherichia | Enterobacteriaceae | Enterobacterales | Gammaproteobacteria | Pseudomonadota | None | Bacteria |
Properties Information
Molecule Weight: 158.11300000000003
TPSA？: 102.48
MolLogP？: -0.2861999999999996
Number of H-Donors: 3
Number of H-Acceptors: 3
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Mus musculus | Dihydroorotase | Km | 4000.0 | nM | 10.1021/jm00368a022 |
| Plasmodium falciparum | Dihydroorotate dehydrogenase | Km | 31.4 | None | 10.1021/jm060687j |
| Plasmodium falciparum (isolate 3D7) | Dihydroorotate dehydrogenase (quinone), mitochondrial | Km | 33000000000.0 | nM | 10.1021/jm060687j |
| Plasmodium falciparum (isolate 3D7) | Dihydroorotate dehydrogenase (quinone), mitochondrial | Km | 35000000000.0 | nM | 10.1021/jm060687j |