Navigation

name Structure Reference Source Properties Activities Metabolism

Ofloxacin

AlkaPlorer ID: AK321846

Synonym: None

IUPAC Name: 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

Structure

SMILES: CC1COC2=C3C(=CC(F)=C2N2CCN(C)CC2)C(=O)C(C(=O)O)=CN31

copy

InChI: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)

copy

InChIKey: GSDSWSVVBLHKDQ-UHFFFAOYSA-N

copy

Properties Information

Molecule Weight: 361.3730000000001

TPSA？: 75.00999999999999

MolLogP？: 1.544

Number of H-Donors: 1

Number of H-Acceptors: 6

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter Acinetobacter MIC 0.39 ug.mL-1 10.1021/jm00395a017
Acinetobacter baumannii Acinetobacter baumannii MIC 0.12 ug.mL-1 10.1007/s00044-010-9338-x
Acinetobacter baumannii Acinetobacter baumannii MIC 0.12 ug.mL-1 10.1016/j.ejmech.2010.05.069
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.00861-09
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1007/s00044-010-9338-x
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.05.069
Acinetobacter baumannii Acinetobacter baumannii MIC 500.0 nM 10.1016/j.bmc.2016.10.009
Acinetobacter baumannii Acinetobacter baumannii MIC 5000.0 nM 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii MIC 32000.0 nM 10.1021/acs.jmedchem.9b00288
Acinetobacter baumannii Acinetobacter baumannii MIC90 1730.0 nM 10.1016/j.ejmech.2020.112821
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 0.25 ug.mL-1 10.1016/S0960-894X(97)00324-7
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 0.39 ug.mL-1 10.1021/jm00169a033
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 0.78 ug.mL-1 10.1016/s0960-894x(98)00514-9
Aliivibrio fischeri Aliivibrio fischeri IZ 27.0 mm 10.1016/j.ejmech.2008.07.004
Aspergillus flavus Aspergillus flavus DIZ nan None 10.1016/j.ejmech.2008.07.004
Aspergillus fumigatus Aspergillus fumigatus DIZ nan None 10.1016/j.ejmech.2008.07.004
Aspergillus fumigatus Aspergillus fumigatus IZ 5.0 mm 10.1007/s00044-012-0143-6
Aspergillus niger Aspergillus niger DIZ nan None 10.1016/j.ejmech.2008.07.004
Aspergillus parasiticus Aspergillus parasiticus DIZ nan None 10.1016/j.ejmech.2008.07.004
Bacillus cereus Bacillus cereus IZ 16.0 mm 10.1007/s00044-009-9198-4
Bacillus cereus Bacillus cereus IZ 19.0 mm 10.1007/s00044-011-9811-1
Bacillus cereus Bacillus cereus IZ 19.0 mm 10.1016/j.ejmech.2008.07.004
Bacillus cereus Bacillus cereus IZ 20.33 mm 10.1007/s00044-012-0371-9
Bacillus cereus Bacillus cereus IZ 28.0 mm 10.1016/j.bmc.2015.04.015
Bacillus cereus Bacillus cereus IZ 28.0 mm 10.1016/j.ejmech.2008.02.038
Bacillus cereus Bacillus cereus IZ 30.0 mm 10.1016/j.ejmech.2006.09.023
Bacillus cereus Bacillus cereus IZ 30.0 mm 10.1016/j.ejmech.2007.01.011
Bacillus cereus Bacillus cereus IZ 44.0 mm 10.1016/j.ejmech.2009.07.003
Bacillus cereus Bacillus cereus MBC 1.6 uM 10.1016/j.ejmech.2018.05.021
Bacillus cereus Bacillus cereus MBC 8.5 uM 10.1016/j.bmcl.2020.127234
Bacillus cereus Bacillus cereus MIC 1.5 ug.mL-1 10.1016/j.ejmech.2013.05.038
Bacillus cereus Bacillus cereus MIC 6.25 ug.mL-1 10.1007/s00044-013-0521-8
Bacillus cereus Bacillus cereus MIC 700.0 nM 10.1021/acs.jnatprod.5b00206
Bacillus cereus Bacillus cereus MIC 800.0 nM 10.1016/j.ejmech.2018.05.021
Bacillus cereus Bacillus cereus MIC 860.0 nM 10.1021/np070483l
Bacillus cereus Bacillus cereus MIC 1400.0 nM 10.1021/acs.jnatprod.5b00206
Bacillus cereus Bacillus cereus MIC 4100.0 nM 10.1016/j.bmcl.2020.127234
Bacillus pumilus Bacillus pumilus IZ 17.0 mm 10.1007/s00044-009-9198-4
Bacillus spizizenii Bacillus spizizenii MIC 0.25 ug.mL-1 10.1016/j.ejmech.2015.11.027
Bacillus spizizenii Bacillus spizizenii MIC 200.0 nM 10.1021/acs.jnatprod.5b00206
Bacillus subtilis Bacillus subtilis Activity 1.38 uM 10.1016/j.bmc.2009.06.023
Bacillus subtilis Bacillus subtilis IZ 2.5 mm 10.1016/j.ejmech.2019.02.055
Bacillus subtilis Bacillus subtilis IZ 10.0 mm 10.1016/j.bmcl.2017.11.020
Bacillus subtilis Bacillus subtilis IZ 17.0 mm 10.1007/s00044-009-9198-4
Bacillus subtilis Bacillus subtilis IZ 20.66 mm 10.1007/s00044-012-0371-9
Bacillus subtilis Bacillus subtilis IZ 22.0 mm 10.1007/s00044-011-9811-1
Bacillus subtilis Bacillus subtilis IZ 24.0 mm 10.1016/j.ejmech.2008.07.004
Bacillus subtilis Bacillus subtilis IZ 31.0 mm 10.1007/s00044-012-0184-x
Bacillus subtilis Bacillus subtilis MIC 0.013 ug.mL-1 10.1021/np500379f
Bacillus subtilis Bacillus subtilis MIC 0.063 ug.mL-1 10.1016/S0960-894X(97)00324-7
Bacillus subtilis Bacillus subtilis MIC 0.1 ug.mL-1 10.1021/jm00169a033
Bacillus subtilis Bacillus subtilis MIC 0.12 ug.mL-1 10.1016/j.ejmech.2007.12.019
Bacillus subtilis Bacillus subtilis MIC 0.125 ug.mL-1 10.1007/s00044-012-0408-0
Bacillus subtilis Bacillus subtilis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2007.09.023
Bacillus subtilis Bacillus subtilis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2008.04.001
Bacillus subtilis Bacillus subtilis MIC 0.19 ug.mL-1 10.1007/s00044-011-9918-4
Bacillus subtilis Bacillus subtilis MIC 0.2 ug.mL-1 10.1021/jm00071a001
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1007/s00044-011-9655-8
Bacillus subtilis Bacillus subtilis MIC 3.125 ug.mL-1 10.1007/s00044-011-9918-4
Bacillus subtilis Bacillus subtilis MIC 3.125 ug.mL-1 10.1007/s00044-013-0521-8
Bacillus subtilis Bacillus subtilis MIC 3.9 ug.mL-1 10.1016/j.ejmech.2007.12.019
Bacillus subtilis Bacillus subtilis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2007.09.023
Bacillus subtilis Bacillus subtilis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2008.04.001
Bacillus subtilis Bacillus subtilis MIC 64.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Bacillus subtilis Bacillus subtilis MIC 500.0 nM 10.1016/j.bmc.2016.10.009
Bacillus subtilis Bacillus subtilis MIC 4096.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Bacillus subtilis Bacillus subtilis MIC nan None 10.1007/s00044-010-9338-x
Bacillus subtilis Bacillus subtilis MIC nan None 10.1007/s00044-012-0408-0
Bacillus subtilis Bacillus subtilis MIC50 0.12 ug.mL-1 10.1128/aac.01380-07
Bacteroides fragilis Bacteroides fragilis MIC 0.5 ug.mL-1 10.1021/jm00117a005
Bacteroides fragilis Bacteroides fragilis MIC50 4.0 ug.mL-1 10.1128/aac.01380-07
Bacteroides fragilis Bacteroides fragilis MIC90 16.0 ug.mL-1 10.1039/C9MD00120D
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Burkholderia cepacia Burkholderia cepacia MIC 3.13 ug.mL-1 10.1016/s0960-894x(98)00514-9
Burkholderia cepacia Burkholderia cepacia MIC 6.25 ug.mL-1 10.1021/jm00169a033
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.13 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.5 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 1.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 2.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 4.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 8.0 ug.mL-1 10.1128/aac.01803-09
Campylobacter coli Campylobacter coli Activity 83.3 % 10.1128/aac.00898-09
Campylobacter jejuni Campylobacter jejuni Activity 40.9 % 10.1128/aac.00898-09
Candida albicans Candida albicans Activity nan None 10.1021/np070483l
Candida albicans Candida albicans IZ 5.0 mm 10.1007/s00044-012-0143-6
Candida albicans Candida albicans IZ 21.0 mm 10.1007/s00044-011-9655-8
Candida albicans Candida albicans IZ 26.0 mm 10.1007/s00044-011-9655-8
Candida albicans Candida albicans IZ 28.0 mm 10.1007/s00044-011-9655-8
Candida albicans Candida albicans MIC 64.0 ug.mL-1 10.1021/acsmedchemlett.8b00612
Candida albicans Candida albicans MIC 10000.0 nM 10.6019/CHEMBL4513141
Candida albicans Candida albicans MIC nan None 10.1007/s00044-010-9338-x
Candida albicans Candida albicans MIC nan None 10.1016/j.ejmech.2007.09.025
Candida parapsilosis Candida parapsilosis MIC nan None 10.1007/s00044-010-9338-x
Candida tropicalis Candida tropicalis MIC 64.0 ug.mL-1 10.1021/acsmedchemlett.8b00612
Canis lupus familiaris MDCK logPapp -4.85 None 10.1021/jm901846t
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlamydia pneumoniae Chlamydia pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00046-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC90 1380.0 nM 10.1021/acs.jnatprod.6b01052
Chlamydia trachomatis Chlamydia trachomatis IC50 666.0 nM 10.1016/j.ejmech.2017.11.099
Chlamydia trachomatis Chlamydia trachomatis IC50 nan None 10.1016/j.ejmech.2017.11.099
Chlamydia trachomatis Chlamydia trachomatis MIC 0.5 ug.mL-1 10.1128/aac.00046-09
Chlamydia trachomatis Chlamydia trachomatis MIC 0.5 ug.mL-1 10.1128/aac.00477-09
Chlamydia trachomatis Chlamydia trachomatis MIC 16.0 ug.mL-1 10.1128/aac.00477-09
Chlamydia trachomatis Chlamydia trachomatis MIC 32.0 ug.mL-1 10.1128/aac.00477-09
Chlorocebus sabaeus Vero CC50 155300.0 nM 10.1007/s00044-011-9638-9
Chlorocebus sabaeus Vero CC50 nan None 10.1016/j.bmc.2012.09.019
Chlorocebus sabaeus Vero IC50 155300.0 nM 10.1016/j.bmcl.2007.11.110
Chlorocebus sabaeus Vero IC50 155300.0 nM 10.1016/j.ejmech.2009.09.033
Citrobacter freundii Citrobacter freundii MIC 0.39 ug.mL-1 10.1016/s0960-894x(98)00514-9
Citrobacter freundii Citrobacter freundii MIC 8.0 ug.mL-1 10.1128/aac.01339-09
Citrobacter freundii Citrobacter freundii MIC 50.0 ug.mL-1 10.1016/s0960-894x(98)00514-9
Citrobacter koseri Citrobacter koseri MIC 0.13 ug.mL-1 10.1016/S0960-894X(97)00324-7
Clostridioides difficile Clostridioides difficile Activity 25.0 % 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile Activity 130.0 % 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile Activity nan None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 2.1 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 3.2 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 3.9 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 4.0 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 4.8 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 22.0 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 32.8 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile FC 67.4 None 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile MIC 8.0 ug.mL-1 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile MIC 32.0 ug.mL-1 10.1128/aac.00532-09
Clostridioides difficile Clostridioides difficile MIC 256.0 ug.mL-1 10.1128/aac.00532-09
Clostridium perfringens Clostridium perfringens MIC50 0.5 ug.mL-1 10.1128/aac.01380-07
Clostridium perfringens Clostridium perfringens MIC90 1.0 ug.mL-1 10.1039/C9MD00120D
Corynebacterium striatum Corynebacterium striatum MIC 354000.0 nM 10.1021/acs.jnatprod.5b00206
Coxiella burnetii Coxiella burnetii MIC 0.25 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 0.5 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 1.0 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 2.0 ug.mL-1 10.1128/aac.01424-08
Cricetulus griseus V79 IC50 500.0 ug.mL-1 10.1021/jm00103a013
Cryptococcus neoformans Cryptococcus neoformans MIC 10000.0 nM 10.6019/CHEMBL4513141
Enterobacter cloacae Enterobacter cloacae MIC 0.031 ug.mL-1 10.1016/S0960-894X(97)00324-7
Enterobacter cloacae Enterobacter cloacae MIC 0.1 ug.mL-1 10.1021/jm00118a026
Enterobacter cloacae Enterobacter cloacae MIC 0.1 ug.mL-1 10.1021/jm00154a003
Enterobacter cloacae Enterobacter cloacae MIC 0.1 ug.mL-1 10.1021/jm00168a018
Enterobacter cloacae Enterobacter cloacae MIC 0.1 ug.mL-1 10.1021/jm00170a035
Enterobacter cloacae Enterobacter cloacae MIC 0.1 ug.mL-1 10.1021/jm00398a003
Enterobacter cloacae Enterobacter cloacae MIC 0.13 ug.mL-1 10.1016/S0960-894X(97)00324-7
Enterobacter cloacae Enterobacter cloacae MIC 0.19 ug.mL-1 10.1021/jm00386a005
Enterobacter cloacae Enterobacter cloacae MIC 0.39 ug.mL-1 10.1016/s0960-894x(98)00514-9
Enterobacter cloacae Enterobacter cloacae MIC 32.0 ug.mL-1 10.1128/aac.01616-06
Enterobacter cloacae Enterobacter cloacae MIC 64.0 ug.mL-1 10.1128/aac.00726-07
Enterobacter cloacae Enterobacter cloacae MIC 500.0 nM 10.1016/j.bmc.2016.10.009
Enterobacter cloacae Enterobacter cloacae MIC90 6920.0 nM 10.1016/j.ejmech.2020.112821
Enterococcus Enterococcus MIC 7800.0 nM 10.1016/j.bmc.2016.10.009
Enterococcus Enterococcus MIC90 2.0 ug.mL-1 10.1039/C9MD00120D
Enterococcus avium Enterococcus avium MIC 6000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus casseliflavus Enterococcus casseliflavus MIC 11000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus durans Enterococcus durans MIC 1400.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecalis Enterococcus faecalis IZ 16.0 mm 10.1007/s00044-009-9198-4
Enterococcus faecalis Enterococcus faecalis MIC 0.39 ug.mL-1 10.1016/S0960-894X(97)00054-1
Enterococcus faecalis Enterococcus faecalis MIC 0.78 ug.mL-1 10.1021/jm00062a007
Enterococcus faecalis Enterococcus faecalis MIC 0.8 ug.mL-1 10.1021/jm00118a026
Enterococcus faecalis Enterococcus faecalis MIC 0.8 ug.mL-1 10.1021/jm00154a003
Enterococcus faecalis Enterococcus faecalis MIC 0.8 ug.mL-1 10.1021/jm00398a003
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1007/s00044-010-9338-x
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1007/s00044-012-0253-1
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2010.05.069
Enterococcus faecalis Enterococcus faecalis MIC 1.5 ug.mL-1 10.1128/aac.00274-07
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1016/s0960-894x(98)00514-9
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1021/jm00043a018
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1021/jm00070a005
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1021/jm00073a014
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1021/jm00168a018
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1021/jm00169a033
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1007/s00044-012-0253-1
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1016/S0960-894X(97)00324-7
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1021/jm00117a005
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1128/aac.00274-07
Enterococcus faecalis Enterococcus faecalis MIC 3.0 ug.mL-1 10.1128/aac.00274-07
Enterococcus faecalis Enterococcus faecalis MIC 3.5 ug.mL-1 10.1128/aac.00274-07
Enterococcus faecalis Enterococcus faecalis MIC 6.3 ug.mL-1 10.1021/jm00170a035
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1007/s00044-010-9338-x
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2010.05.069
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1128/aac.00274-07
Enterococcus faecalis Enterococcus faecalis MIC 860.0 nM 10.1021/np070483l
Enterococcus faecalis Enterococcus faecalis MIC 3000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecalis Enterococcus faecalis MIC 6000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecalis Enterococcus faecalis MIC 11000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecalis Enterococcus faecalis MIC 354000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecalis Enterococcus faecalis MIC 1560000.0 ug.mL-1 10.1021/jm00031a007
Enterococcus faecalis Enterococcus faecalis MIC50 1.0 ug.mL-1 10.1128/aac.01380-07
Enterococcus faecalis Enterococcus faecalis MIC>90 2.3 ug ml-1 10.1021/np400145u
Enterococcus faecium Enterococcus faecium MIC 0.78 ug.mL-1 10.1021/jm00395a017
Enterococcus faecium Enterococcus faecium MIC 6000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecium Enterococcus faecium MIC 22000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecium Enterococcus faecium MIC 177000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus faecium Enterococcus faecium MIC 354000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus gallinarum Enterococcus gallinarum MIC 6000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus gallinarum Enterococcus gallinarum MIC 11000.0 nM 10.1021/acs.jnatprod.5b00206
Enterococcus hirae Enterococcus hirae MIC 3000.0 nM 10.1021/acs.jnatprod.5b00206
Equus caballus Ferritin light chain Potency 31622.8 nM None
Escherichia coli DNA gyrase CC25 0.2 uM 10.1128/aac.01380-07
Escherichia coli DNA gyrase Concentration 5.0 ug ml-1 10.1021/jm00398a003
Escherichia coli DNA gyrase IC50 1.75 ug.mL-1 10.1016/S0960-894X(01)80881-7
Escherichia coli DNA gyrase IC50 1.8 ug.mL-1 10.1016/s0960-894x(97)10197-4
Escherichia coli DNA gyrase IC50 6.3 ug.mL-1 10.1021/jm00153a015
Escherichia coli DNA gyrase IC50 7.5 ug.mL-1 10.1021/jm00398a003
Escherichia coli DNA gyrase IC50 1500.0 nM 10.1128/aac.01380-07
Escherichia coli DNA gyrase MIC 5.0 ug.mL-1 10.1021/jm00153a015
Escherichia coli DNA gyrase Min concentration 5.0 ug ml-1 10.1021/jm00154a003
Escherichia coli Escherichia coli Activity 1.3 % 10.1128/aac.00144-08
Escherichia coli Escherichia coli Activity 1.38 uM 10.1016/j.bmc.2009.06.023
Escherichia coli Escherichia coli Activity 1.7 % 10.1128/aac.00144-08
Escherichia coli Escherichia coli Activity 3.3 % 10.1128/aac.00144-08
Escherichia coli Escherichia coli Activity 33.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity 98.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00014-10
Escherichia coli Escherichia coli ED50 0.009 mg mouse-1 10.1021/jm00062a007
Escherichia coli Escherichia coli ED50 0.55 mg.kg-1 10.1016/j.ejmech.2018.08.095
Escherichia coli Escherichia coli ED50 1.1 mg.kg-1 10.1016/j.ejmech.2018.08.095
Escherichia coli Escherichia coli IC50 0.3 ug.mL-1 10.1128/aac.01380-07
Escherichia coli Escherichia coli IC50 0.53 ug.mL-1 10.1021/jm00073a014
Escherichia coli Escherichia coli IC50 2.25 ug.mL-1 10.1021/jm00118a026
Escherichia coli Escherichia coli Inhibition nan % 10.1128/aac.00014-10
Escherichia coli Escherichia coli IZ 2.5 mm 10.1016/j.ejmech.2019.02.055
Escherichia coli Escherichia coli IZ 11.0 mm 10.1016/j.bmcl.2017.11.020
Escherichia coli Escherichia coli IZ 15.0 mm 10.1007/s00044-012-0143-6
Escherichia coli Escherichia coli IZ 17.0 mm 10.1007/s00044-009-9198-4
Escherichia coli Escherichia coli IZ 21.5 mm 10.1007/s00044-012-0371-9
Escherichia coli Escherichia coli IZ 22.0 mm 10.1016/j.ejmech.2018.08.095
Escherichia coli Escherichia coli IZ 23.0 mm 10.1007/s00044-011-9811-1
Escherichia coli Escherichia coli IZ 23.0 mm 10.1016/j.ejmech.2008.07.004
Escherichia coli Escherichia coli IZ 24.0 mm 10.1016/j.bmc.2015.04.015
Escherichia coli Escherichia coli IZ 24.0 mm 10.1016/j.ejmech.2019.03.021
Escherichia coli Escherichia coli IZ 30.0 mm 10.1016/j.ejmech.2006.09.023
Escherichia coli Escherichia coli IZ 30.0 mm 10.1016/j.ejmech.2007.01.011
Escherichia coli Escherichia coli IZ 30.0 mm 10.1016/j.ejmech.2008.02.038
Escherichia coli Escherichia coli IZ 30.0 mm 10.1016/j.ejmech.2009.07.003
Escherichia coli Escherichia coli IZ 31.0 mm 10.1007/s00044-012-0184-x
Escherichia coli Escherichia coli MIC 0.004 ug.mL-1 10.1128/aac.00726-07
Escherichia coli Escherichia coli MIC 0.008 ug.mL-1 10.1021/jm00117a005
Escherichia coli Escherichia coli MIC 0.008 ug.mL-1 10.1128/aac.00274-07
Escherichia coli Escherichia coli MIC 0.008 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 0.01 ug.mL-1 10.1128/aac.00070-07
Escherichia coli Escherichia coli MIC 0.01 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 0.01 ug.mL-1 10.1128/aac.01616-06
Escherichia coli Escherichia coli MIC 0.013 ug.mL-1 10.1128/aac.00475-08
Escherichia coli Escherichia coli MIC 0.015 ug.mL-1 10.1016/S0960-894X(01)80881-7
Escherichia coli Escherichia coli MIC 0.015 ug.mL-1 10.1128/aac.00997-08
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1016/S0960-894X(97)00324-7
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1128/aac.00274-07
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 0.023 ug.mL-1 10.1128/aac.01339-09
Escherichia coli Escherichia coli MIC 0.025 ug.mL-1 10.1016/s0960-894x(98)00514-9
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.00274-07
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 0.031 ug.mL-1 10.1016/S0960-894X(97)00324-7
Escherichia coli Escherichia coli MIC 0.032 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 0.032 ug.mL-1 10.1128/aac.00997-08
Escherichia coli Escherichia coli MIC 0.05 ug.mL-1 10.1016/S0960-894X(97)00054-1
Escherichia coli Escherichia coli MIC 0.05 ug.mL-1 10.1021/jm00062a007
Escherichia coli Escherichia coli MIC 0.05 ug.mL-1 10.1021/jm00118a026
Escherichia coli Escherichia coli MIC 0.05 ug.mL-1 10.1021/jm00168a018
Escherichia coli Escherichia coli MIC 0.05 ug.mL-1 10.1021/jm00395a017
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1021/acs.jmedchem.6b00580
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00349-08
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00726-07
Escherichia coli Escherichia coli MIC 0.0625 ug.mL-1 10.1016/S0960-894X(01)80881-7
Escherichia coli Escherichia coli MIC 0.063 ug.mL-1 10.1016/S0960-894X(97)00324-7
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.00294-09
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.01339-09
Escherichia coli Escherichia coli MIC 0.08 ug.mL-1 10.1016/j.ejmech.2008.01.042
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1016/j.bmcl.2010.10.057
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1016/j.bmcl.2014.10.039
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1016/j.ejmech.2018.08.095
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1016/s0960-894x(98)00514-9
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00043a018
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00062a007
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00070a005
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00073a014
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00103a011
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00118a026
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00154a003
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00169a033
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00395a017
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00398a003
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1007/s00044-010-9338-x
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1007/s00044-012-0253-1
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1016/j.ejmech.2007.12.019
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1016/j.ejmech.2010.05.069
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01616-06
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1007/s00044-012-0408-0
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1016/j.ejmech.2007.09.023
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1016/j.ejmech.2008.04.001
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00274-07
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00997-08
Escherichia coli Escherichia coli MIC 0.16 ug.mL-1 10.1016/j.ejmech.2008.01.042
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1007/s00044-011-9918-4
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1021/jm00386a005
Escherichia coli Escherichia coli MIC 0.2 ug.mL-1 10.1016/j.ejmech.2018.08.095
Escherichia coli Escherichia coli MIC 0.2 ug.mL-1 10.1021/jm00071a001
Escherichia coli Escherichia coli MIC 0.2 ug.mL-1 10.1021/jm00169a033
Escherichia coli Escherichia coli MIC 0.2 ug.mL-1 10.1021/jm00170a035
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1016/j.ejmech.2015.11.027
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00070-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00997-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01339-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01616-06
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1007/s00044-010-9338-x
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.ejmech.2010.05.069
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.ejmech.2013.05.038
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/S0960-894X(01)80881-7
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/S0960-894X(97)00324-7
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00070-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00726-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00997-08
Escherichia coli Escherichia coli MIC 0.78 ug.mL-1 10.1016/s0960-894x(98)00514-9
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1007/s00044-011-9655-8
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00349-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01339-09
Escherichia coli Escherichia coli MIC 1.024 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 1.25 ug.mL-1 10.1039/C8MD00212F
Escherichia coli Escherichia coli MIC 3.125 ug.mL-1 10.1007/s00044-013-0521-8
Escherichia coli Escherichia coli MIC 6.2 ug.mL-1 10.1021/jm00170a035
Escherichia coli Escherichia coli MIC 6.25 ug.mL-1 10.1007/s00044-011-9918-4
Escherichia coli Escherichia coli MIC 6.25 ug.mL-1 10.1016/j.ejmech.2007.09.025
Escherichia coli Escherichia coli MIC 7.8 ug.mL-1 10.1016/j.ejmech.2007.12.019
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01339-09
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1007/s00044-011-9840-9
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1007/s00044-012-0253-1
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2007.09.023
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2008.04.001
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00349-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/acsmedchemlett.8b00612
Escherichia coli Escherichia coli MIC 78.1 nM 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC 80.0 nM 10.1021/jm501552x
Escherichia coli Escherichia coli MIC 125.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 240.0 nM 10.1021/jm501552x
Escherichia coli Escherichia coli MIC 390.0 nM 10.1016/j.ejmech.2022.114333
Escherichia coli Escherichia coli MIC 430.0 nM 10.1021/np070483l
Escherichia coli Escherichia coli MIC 500.0 nM 10.1016/j.ejmech.2018.05.021
Escherichia coli Escherichia coli MIC 500.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 780.0 nM 10.1016/s0960-894x(03)00285-3
Escherichia coli Escherichia coli MIC 3900.0 nM 10.1016/j.bmc.2016.10.009
Escherichia coli Escherichia coli MIC 4096.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Escherichia coli Escherichia coli MIC 100000.0 ug.mL-1 10.1021/jm00031a007
Escherichia coli Escherichia coli MIC nan None 10.1007/s00044-012-0408-0
Escherichia coli Escherichia coli MIC50 0.01 ug.mL-1 10.1128/aac.01380-07
Escherichia coli Escherichia coli MIC50 0.5 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC50 4.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC90 0.12 ug.mL-1 10.1039/C9MD00120D
Escherichia coli Escherichia coli MIC90 4.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli PD50 0.8 mg kg-1 10.1021/jm00398a003
Escherichia coli Escherichia coli PD50 2.0 mg kg-1 10.1021/jm00398a003
Escherichia coli Escherichia coli Ratio 3.0 None 10.1021/jm501552x
Haemophilus influenzae Haemophilus influenzae MIC50 0.01 ug.mL-1 10.1128/aac.01380-07
Haemophilus influenzae Haemophilus influenzae MIC50 0.012 ug.mL-1 10.1128/aac.01380-07
Haemophilus influenzae Haemophilus influenzae MIC90 0.03 ug.mL-1 10.1039/C9MD00120D
Helicobacter pylori Helicobacter pylori MIC50 0.06 ug.mL-1 10.1128/aac.01380-07
Helicobacter pylori Helicobacter pylori MIC50 0.25 ug.mL-1 10.1128/aac.01380-07
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 3162.3 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 25118.9 nM None
Homo sapiens 5637 Activity nan None 10.1128/aac.00014-10
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 19952.6 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 25118.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 1000000.0 nM 10.1124/dmd.112.047068
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 83.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Casein kinase II Activity 100.0 % 10.1021/jm050048t
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cerebroside-sulfatase Potency 4256.2 nM None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 112201.8 nM None
Homo sapiens DNA topoisomerase II beta CC50 2.1 ug.mL-1 10.1016/S0960-894X(01)80881-7
Homo sapiens DNA topoisomerase II beta IC50 1.0 ug.mL-1 10.1021/jm00117a005
Homo sapiens DNA topoisomerase II beta Ki 1.6 ug ml-1 10.1021/jm00395a017
Homo sapiens DNA topoisomerase II beta Ki 84.0 ug ml-1 10.1021/jm00395a017
Homo sapiens DNA topoisomerase II beta MIC 0.1 ug.mL-1 10.1021/jm00153a015
Homo sapiens DNA topoisomerase II beta MIC 0.4 ug.mL-1 10.1021/jm00153a015
Homo sapiens DNA topoisomerase II beta MIC 0.8 ug.mL-1 10.1021/jm00153a015
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 10000.0 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
Homo sapiens Endothelin receptor ET-A AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Flap endonuclease 1 Potency 37685.8 nM None
Homo sapiens GABA-A receptor; anion channel Currents 39.0 % 10.1021/jm00062a007
Homo sapiens GABA-A receptor; anion channel Currents 87.0 % 10.1021/jm00062a007
Homo sapiens GABA-A receptor; anion channel Currents 94.0 % 10.1021/jm00062a007
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HEK293 CC50 10000.0 nM 10.6019/CHEMBL4513141
Homo sapiens HERG AC50 470002.3 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 1412537.54 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 1412537.54 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 1412537.54 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 1412537.54 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 1420000.0 nM 10.1016/j.bmcl.2013.04.074
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 25204.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone acetyltransferase GCN5 Potency 19952.6 nM None
Homo sapiens Histone deacetylase 6 Inhibition -13.63 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -8.09 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 2.52 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 12.48 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 8912.5 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 56234.1 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity 1.0 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens AUC 14100.0 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 21200.0 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 31400.0 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 41200.0 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 43500.0 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 61000.0 ng.hr.mL-1 None
Homo sapiens Homo sapiens CL 0.8 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 3.5 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 3.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 2.7 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 2.7 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Cmax 4150.87 nM None
Homo sapiens Homo sapiens Cmax 6087.94 nM None
Homo sapiens Homo sapiens Cmax 6641.39 nM None
Homo sapiens Homo sapiens Cmax 8025.02 nM None
Homo sapiens Homo sapiens Cmax 9962.09 nM None
Homo sapiens Homo sapiens Cmax 12729.34 nM None
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 90.0 % 10.1021/jm901421c
Homo sapiens Homo sapiens F 90.0 % 10.1021/jm901846t
Homo sapiens Homo sapiens F 98.0 % None
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 1.04 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.97 None 10.1021/jm901371v
Homo sapiens Homo sapiens T1/2 4.0 hr None
Homo sapiens Homo sapiens Tmax 1.0 hr None
Homo sapiens Homo sapiens Vdss 1.6 L.kg-1 10.1021/jm901371v
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens Lysine-specific demethylase 4D-like Potency 3162.3 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 15848.9 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 22387.2 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 28183.8 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MT4 CC50 200000.0 nM 10.1016/s0960-894x(99)00251-6
Homo sapiens Multidrug resistance-associated protein 1 Activity 0.29 None 10.1128/aac.44.6.1697-1700.2000
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 189998.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 32642.7 nM None
Homo sapiens Parathyroid hormone receptor Potency 79432.8 nM None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Serum albumin Kd 12000.0 nM 10.1128/aac.00971-08
Homo sapiens Serum albumin Ratio 0.5 None 10.1128/aac.00971-08
Homo sapiens Serum albumin Ratio 1.0 None 10.1128/aac.00971-08
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier family 22 member 1 Inhibition 21.1 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 4 Activity 61.4 % None
Homo sapiens Solute carrier family 22 member 5 Activity 76.8 % None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition -8.2 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 65.85 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 24.5 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 89.51 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 18.4 % 10.1021/jm300212s
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 12995.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 16360.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 20596.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Human immunodeficiency virus Human immunodeficiency virus Activity nan None 10.1007/s00044-012-0143-6
Human immunodeficiency virus Human immunodeficiency virus IC50 nan None 10.1007/s00044-012-0143-6
Klebsiella Klebsiella MIC90 0.5 ug.mL-1 10.1039/C9MD00120D
Klebsiella aerogenes Klebsiella aerogenes CMI 0.12 mg l-1 10.1016/s0960-894x(03)00544-4
Klebsiella aerogenes Klebsiella aerogenes IZ 21.0 mm 10.1007/s00044-011-9811-1
Klebsiella aerogenes Klebsiella aerogenes IZ 24.0 mm 10.1016/j.ejmech.2008.07.004
Klebsiella aerogenes Klebsiella aerogenes MIC 0.064 ug.mL-1 10.1128/aac.00710-10
Klebsiella aerogenes Klebsiella aerogenes MIC 0.1 ug.mL-1 10.1021/jm00169a033
Klebsiella aerogenes Klebsiella aerogenes MIC 0.13 ug.mL-1 10.1016/S0960-894X(97)00324-7
Klebsiella aerogenes Klebsiella aerogenes MIC 0.2 ug.mL-1 10.1021/jm00395a017
Klebsiella aerogenes Klebsiella aerogenes MIC 0.25 ug.mL-1 10.1016/S0960-894X(97)00324-7
Klebsiella aerogenes Klebsiella aerogenes MIC 0.512 ug.mL-1 10.1128/aac.00710-10
Klebsiella aerogenes Klebsiella aerogenes MIC90 220.0 nM 10.1016/j.ejmech.2020.112821
Klebsiella oxytoca Klebsiella oxytoca MIC 0.1 ug.mL-1 10.1016/s0960-894x(98)00514-9
Klebsiella oxytoca Klebsiella oxytoca MIC50 0.01 ug.mL-1 10.1128/aac.01380-07
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1128/aac.00710-10
Klebsiella pneumoniae Klebsiella pneumoniae IZ 19.0 mm 10.1007/s00044-009-9198-4
Klebsiella pneumoniae Klebsiella pneumoniae IZ 20.33 mm 10.1007/s00044-012-0371-9
Klebsiella pneumoniae Klebsiella pneumoniae IZ 28.0 mm 10.1016/j.ejmech.2006.09.023
Klebsiella pneumoniae Klebsiella pneumoniae IZ 28.0 mm 10.1016/j.ejmech.2007.01.011
Klebsiella pneumoniae Klebsiella pneumoniae IZ 28.0 mm 10.1016/j.ejmech.2008.02.038
Klebsiella pneumoniae Klebsiella pneumoniae IZ 28.0 mm 10.1016/j.ejmech.2009.07.003
Klebsiella pneumoniae Klebsiella pneumoniae IZ 31.0 mm 10.1007/s00044-012-0184-x
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.025 ug.mL-1 10.1021/jm00103a011
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.05 ug.mL-1 10.1016/s0960-894x(98)00514-9
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.05 ug.mL-1 10.1021/jm00169a033
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.05 ug.mL-1 10.1021/jm00395a017
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.06 ug.mL-1 10.1007/s00044-011-9655-8
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00043a018
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00070a005
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00071a001
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00073a014
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00118a026
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00154a003
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00168a018
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00398a003
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.12 ug.mL-1 10.1007/s00044-010-9338-x
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.12 ug.mL-1 10.1016/j.ejmech.2007.12.019
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.12 ug.mL-1 10.1016/j.ejmech.2010.05.069
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.19 ug.mL-1 10.1007/s00044-011-9918-4
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.2 ug.mL-1 10.1016/s0960-894x(98)00514-9
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.2 ug.mL-1 10.1021/jm00170a035
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1016/j.ejmech.2007.09.023
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1016/j.ejmech.2008.04.001
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.39 ug.mL-1 10.1021/jm00386a005
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1007/s00044-010-9338-x
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1016/j.ejmech.2010.05.069
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 3.125 ug.mL-1 10.1007/s00044-011-9918-4
Klebsiella pneumoniae Klebsiella pneumoniae MIC 3.9 ug.mL-1 10.1016/j.ejmech.2007.12.019
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.00726-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2007.09.023
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2008.04.001
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2048.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Klebsiella pneumoniae Klebsiella pneumoniae MIC 5000.0 nM 10.6019/CHEMBL4513141
Klebsiella pneumoniae Klebsiella pneumoniae MIC 15600.0 nM 10.1016/j.bmc.2016.10.009
Klebsiella pneumoniae Klebsiella pneumoniae MIC 100000.0 ug.mL-1 10.1021/jm00031a007
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 nan None 10.1016/j.ejmech.2020.112821
Kocuria rhizophila Kocuria rhizophila MIC 1.56 ug.mL-1 10.1021/np900522h
Lactococcus lactis Lactococcus lactis MIC 1.0 ug.mL-1 10.1128/aac.00274-07
Lactococcus lactis Lactococcus lactis MIC 4.0 ug.mL-1 10.1128/aac.00274-07
Lipomyces lipofer Lipomyces lipofer DIZ nan None 10.1016/j.ejmech.2008.07.004
Listeria innocua Listeria innocua MIC 11000.0 nM 10.1021/acs.jnatprod.5b00206
Listeria monocytogenes Listeria monocytogenes IZ 21.0 mm 10.1016/j.bmc.2019.115097
Listeria monocytogenes Listeria monocytogenes IZ 30.0 mm 10.1016/j.ejmech.2006.09.023
Listeria monocytogenes Listeria monocytogenes IZ 30.0 mm 10.1016/j.ejmech.2007.01.011
Listeria monocytogenes Listeria monocytogenes IZ 30.0 mm 10.1016/j.ejmech.2008.02.038
Listeria monocytogenes Listeria monocytogenes IZ 30.0 mm 10.1016/j.ejmech.2009.07.003
Listeria monocytogenes Listeria monocytogenes MIC 1000.0 nM 10.1016/j.bmc.2016.10.009
Listeria monocytogenes Listeria monocytogenes MIC 6000.0 nM 10.1021/acs.jnatprod.5b00206
Mammaliicoccus sciuri Mammaliicoccus sciuri MIC 3000.0 nM 10.1021/acs.jnatprod.5b00206
Micrococcus luteus Micrococcus luteus IZ 28.0 mm 10.1016/j.ejmech.2006.09.023
Micrococcus luteus Micrococcus luteus IZ 28.0 mm 10.1016/j.ejmech.2007.01.011
Micrococcus luteus Micrococcus luteus IZ 28.0 mm 10.1016/j.ejmech.2009.07.003
Micrococcus luteus Micrococcus luteus IZ 44.0 mm 10.1016/j.ejmech.2008.02.038
Micrococcus luteus Micrococcus luteus MIC 1.6 ug.mL-1 10.1021/np500379f
Micrococcus luteus Micrococcus luteus MIC 2.0 ug.mL-1 10.1016/S0960-894X(97)00324-7
Micrococcus luteus Micrococcus luteus MIC 3.1 ug.mL-1 10.1021/jm00395a017
Micrococcus luteus Micrococcus luteus MIC 3.13 ug.mL-1 10.1021/jm00043a018
Micrococcus luteus Micrococcus luteus MIC 3.13 ug.mL-1 10.1021/jm00103a011
Micrococcus luteus Micrococcus luteus MIC 3130000.0 ug.mL-1 10.1021/jm00031a007
Moraxella bovis Moraxella bovis MIC 1.56 ug.mL-1 10.1021/jm00168a018
Morganella morganii Morganella morganii MIC 0.78 ug.mL-1 10.1021/jm00386a005
Mus musculus Mus musculus AUC 29000.0 ng.hr.mL-1 10.1128/aac.00414-06
Mus musculus Mus musculus Cmax 4704.32 nM 10.1128/aac.00414-06
Mus musculus Mus musculus Convulsion 0.0 % 10.1021/jm00062a007
Mus musculus Mus musculus ED50 0.55 mg.kg-1 10.1021/jm00103a011
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1021/jm00031a007
Mus musculus Mus musculus ED50 6.62 mg.kg-1 10.1021/jm00168a018
Mus musculus Mus musculus ED50 10.8 mg.kg-1 10.1021/jm00168a018
Mus musculus Mus musculus ED50 11.0 mg.kg-1 10.1021/jm00031a007
Mus musculus Mus musculus ED50 11.4 mg.kg-1 10.1021/jm00043a018
Mus musculus Mus musculus ED50 14.6 mg.kg-1 10.1021/jm00043a018
Mus musculus Mus musculus ED50 23.01 mg.kg-1 10.1021/jm00103a011
Mus musculus Mus musculus Inhibition nan % 10.1016/j.ejmech.2016.08.034
Mus musculus Mus musculus LD50 3000.0 mg.kg-1 10.1128/aac.00414-06
Mus musculus Mus musculus LD50 5450.0 mg.kg-1 10.1016/j.bmc.2016.06.020
Mus musculus Mus musculus LD50 5450.0 mg.kg-1 10.1016/j.bmcl.2016.03.107
Mus musculus Mus musculus PD50 0.8 mg kg-1 10.1021/jm00118a026
Mus musculus Mus musculus PD50 0.8 mg kg-1 10.1021/jm00154a003
Mus musculus Mus musculus PD50 1.2 mg kg-1 10.1021/jm00117a005
Mus musculus Mus musculus PD50 2.0 mg kg-1 10.1021/jm00118a026
Mus musculus Mus musculus PD50 2.0 mg kg-1 10.1021/jm00154a003
Mus musculus Mus musculus PD50 2.2 mg kg-1 10.1021/jm00117a005
Mus musculus Mus musculus PD50 5.0 mg kg-1 10.1021/jm00154a003
Mus musculus Mus musculus PD50 11.0 mg kg-1 10.1021/jm00154a003
Mus musculus Mus musculus PD50 38.0 mg kg-1 10.1021/jm00154a003
Mus musculus Mus musculus PD50 68.0 mg kg-1 10.1021/jm00154a003
Mus musculus Mus musculus Permeability nan None 10.1021/jm990968+
Mus musculus Mus musculus T1/2 4.93 hr 10.1128/aac.00414-06
Mus musculus Mus musculus T>MIC 0.0 % 10.1128/aac.00414-06
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Plasma Fu 0.0 None 10.1128/aac.00414-06
Mus musculus RAW264.7 Activity nan None 10.1016/j.bmc.2017.12.044
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmc.2014.06.041
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmc.2014.10.016
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmc.2015.02.032
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.ejmech.2014.09.028
Mycobacterium avium Mycobacterium avium MIC 0.1 ug.mL-1 10.1016/j.bmcl.2016.03.107
Mycobacterium avium Mycobacterium avium MIC 0.1 ug.mL-1 10.1016/j.bmcl.2016.04.017
Mycobacterium avium Mycobacterium avium MIC 4.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 16.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 64.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 280.0 nM 10.1016/j.bmc.2016.06.020
Mycobacterium avium Mycobacterium avium MIC50 1500.0 nM 10.1016/s0960-894x(99)00251-6
Mycobacterium avium Mycobacterium avium MIC90 3000.0 nM 10.1016/s0960-894x(99)00251-6
Mycobacterium leprae Mycobacterium leprae Activity 0.0 % 10.1016/j.bmc.2019.04.032
Mycobacterium leprae Mycobacterium leprae Activity 20.0 None 10.1128/aac.01282-06
Mycobacterium leprae Mycobacterium leprae Activity 72.0 % 10.1016/j.bmc.2019.04.032
Mycobacterium leprae Mycobacterium leprae Activity 99.0 % 10.1128/aac.01282-06
Mycobacterium leprae Mycobacterium leprae Activity 121.0 % 10.1016/j.bmc.2019.04.032
Mycobacterium leprae Mycobacterium leprae Activity 124.0 % 10.1016/j.bmc.2019.04.032
Mycobacterium leprae Mycobacterium leprae CC25 8.0 ug ml-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae CC25 9.0 ug ml-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae CC25 10.0 ug ml-1 10.1016/j.bmc.2012.12.011
Mycobacterium leprae Mycobacterium leprae CC25 10.0 ug ml-1 10.1128/aac.01282-06
Mycobacterium leprae Mycobacterium leprae CC25 110.0 ug ml-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae CC25 240.0 ug ml-1 10.1016/j.bmc.2012.12.011
Mycobacterium leprae Mycobacterium leprae CC25 nan None 10.1016/j.bmc.2012.12.011
Mycobacterium leprae Mycobacterium leprae CC25 nan None 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae FC 3.0 None 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae FC 5.0 None 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae FC 12.0 None 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae FICI 0.5 None 10.1016/j.bmc.2019.04.032
Mycobacterium leprae Mycobacterium leprae FICI 1.0 None 10.1016/j.bmc.2019.04.032
Mycobacterium leprae Mycobacterium leprae IC50 8.0 ug.mL-1 10.1016/j.bmc.2012.12.011
Mycobacterium leprae Mycobacterium leprae IC50 10.0 ug.mL-1 10.1128/aac.01282-06
Mycobacterium leprae Mycobacterium leprae IC50 15.0 ug.mL-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae IC50 20.0 ug.mL-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae IC50 80.0 ug.mL-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae IC50 160.0 ug.mL-1 10.1128/aac.01095-07
Mycobacterium marinum Mycobacterium marinum MIC90 6920.0 nM 10.1016/j.ejmech.2020.112821
Mycobacterium smegmatis DNA gyrase subunit B IC50 nan None 10.1016/j.bmc.2014.06.041
Mycobacterium smegmatis DNA gyrase subunit B IC50 nan None 10.1016/j.bmc.2014.10.016
Mycobacterium smegmatis DNA gyrase subunit B IC50 nan None 10.1016/j.bmc.2015.02.032
Mycobacterium smegmatis DNA gyrase subunit B IC50 nan None 10.1016/j.ejmech.2016.08.034
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) DNA gyrase subunit B IC50 nan None 10.1016/j.ejmech.2016.06.042
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1016/j.ejmech.2012.04.014
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1128/aac.00414-06
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1128/aac.00661-10
Mycobacterium tuberculosis Mycobacterium tuberculosis GI 62.0 % 10.1016/j.ejmech.2018.01.080
Mycobacterium tuberculosis Mycobacterium tuberculosis GI 100.0 % 10.1016/j.bmc.2012.09.019
Mycobacterium tuberculosis Mycobacterium tuberculosis GI 100.0 % 10.1016/j.bmc.2013.07.003
Mycobacterium tuberculosis Mycobacterium tuberculosis IC50 0.5 ug.mL-1 10.1007/s00044-012-0101-3
Mycobacterium tuberculosis Mycobacterium tuberculosis IC50 10.0 ug.mL-1 10.1128/aac.01380-07
Mycobacterium tuberculosis Mycobacterium tuberculosis Log10 cfu 1.5 None 10.1128/aac.00414-06
Mycobacterium tuberculosis Mycobacterium tuberculosis Log10 cfu 6.61 None 10.1016/j.bmcl.2007.11.110
Mycobacterium tuberculosis Mycobacterium tuberculosis Log10 cfu 7.61 None 10.1016/j.bmcl.2007.11.110
Mycobacterium tuberculosis Mycobacterium tuberculosis log10CFU/ml 3.0 None 10.1128/aac.00414-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.1 ug.mL-1 10.1016/j.bmcl.2016.03.107
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.1 ug.mL-1 10.1016/j.bmcl.2016.04.017
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2011.12.029
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.25 ug.mL-1 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.391 ug.mL-1 10.1021/acs.jnatprod.5b00961
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.391 ug.mL-1 10.1021/np5005328
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.4 ug.mL-1 10.1021/acs.jnatprod.0c01212
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1021/jm500432n
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1128/aac.00414-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1128/aac.00661-10
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.bmc.2012.12.011
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1021/jm500432n
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.02.053
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2009.07.015
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2014.10.026
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1128/aac.00414-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2012.02.053
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1016/j.ejmech.2014.10.026
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1021/jm500432n
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1128/aac.00541-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8.0 ug.mL-1 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8.0 ug.mL-1 10.1128/aac.00541-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8.0 ug.mL-1 10.1128/aac.00661-10
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 12.0 ug.mL-1 10.1128/aac.00541-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1021/jm500432n
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1128/aac.00661-10
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 32.0 ug.mL-1 10.1128/aac.00287-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 125.0 nM 10.1016/j.ejmech.2014.05.069
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 280.0 nM 10.1016/j.bmc.2016.06.020
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 500.0 nM 10.1016/j.ejmech.2014.05.069
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 500.0 nM 10.1016/j.ejmech.2016.11.041
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 690.0 nM 10.1016/j.bmcl.2014.03.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 700.0 nM 10.1021/jm5002937
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 700.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1000.0 nM 10.1016/j.ejmech.2016.11.041
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1000.0 nM 10.1016/j.ejmech.2020.112967
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2000.0 nM 10.1016/j.ejmech.2016.11.041
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2130.0 nM 10.1007/s00044-011-9638-9
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2130.0 nM 10.1016/j.ejmech.2009.09.033
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.bmc.2014.06.041
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.bmc.2014.08.031
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.bmc.2014.10.016
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.bmc.2015.02.032
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.bmc.2017.12.044
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.bmcl.2017.01.026
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.ejmech.2014.09.028
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2160.0 nM 10.1016/j.ejmech.2016.06.042
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2300.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2700.0 nM 10.1016/j.bmcl.2017.01.024
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 5000.0 nM 10.1021/jm5002937
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 5500.0 nM 10.1016/j.bmcl.2017.01.024
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8000.0 nM 10.1016/j.ejmech.2014.05.069
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8000.0 nM 10.1016/j.ejmech.2016.11.041
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16000.0 nM 10.1016/j.ejmech.2014.05.069
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16000.0 nM 10.1016/j.ejmech.2016.11.041
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 24200.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 32000.0 nM 10.1016/j.ejmech.2014.05.069
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 34590.0 nM 10.1007/s00044-011-9638-9
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 34590.0 nM 10.1016/j.bmc.2014.08.031
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 34590.0 nM 10.1016/j.ejmech.2009.09.033
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 34590.0 nM 10.1016/j.ejmech.2014.09.028
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 128000.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1016/j.ejmech.2014.09.028
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 1.0 ug.mL-1 10.1128/aac.01380-07
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 2000.0 nM 10.1016/s0960-894x(99)00251-6
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 3000.0 nM 10.1016/s0960-894x(99)00251-6
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=>80 0.3 uM 10.1039/C5MD00589B
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=>80 0.7 uM 10.1039/C5MD00589B
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=>80 5.6 uM 10.1039/C5MD00589B
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=<90 0.5 ug ml-1 10.1016/j.ejmech.2021.113202
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=<90 4.0 ug ml-1 10.1016/j.ejmech.2021.113202
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=<90 8.0 ug ml-1 10.1016/j.ejmech.2021.113202
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 8.0 ug.mL-1 10.1021/jm500432n
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 1730.0 nM 10.1016/j.ejmech.2020.112821
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 3000.0 nM 10.1016/s0960-894x(99)00251-6
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 13800.0 nM 10.1016/j.ejmech.2020.112821
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 27600.0 nM 10.1016/j.ejmech.2020.112821
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 0.5 uM 10.1016/j.bmc.2017.08.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 0.5 uM 10.1021/acs.jmedchem.5b00608
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 0.5 uM 10.1021/acs.jmedchem.9b00912
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 1.0 uM 10.1016/j.bmc.2017.08.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 1.0 uM 10.1021/acs.jmedchem.5b00608
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 1.0 uM 10.1021/acs.jmedchem.9b00912
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 2.0 uM 10.1016/j.bmc.2017.08.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 2.0 uM 10.1021/acs.jmedchem.5b00608
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 2.0 uM 10.1021/acs.jmedchem.9b00912
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 8.0 uM 10.1016/j.bmc.2017.08.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 8.0 uM 10.1021/acs.jmedchem.5b00608
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 8.0 uM 10.1021/acs.jmedchem.9b00912
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 16.0 uM 10.1016/j.bmc.2017.08.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 16.0 uM 10.1021/acs.jmedchem.5b00608
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 16.0 uM 10.1021/acs.jmedchem.9b00912
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 2.0 ug ml-1 10.1016/j.bmc.2012.09.019
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 2.0 ug ml-1 10.1016/j.bmc.2013.07.003
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 2.16 uM 10.1016/j.bmcl.2007.11.110
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 34.59 uM 10.1016/j.bmcl.2007.11.110
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B CC25 7.0 uM 10.1128/aac.01380-07
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 6.0 ug.mL-1 10.1016/j.bmc.2012.12.011
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 28000.0 nM 10.1128/aac.01380-07
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 nan None 10.1016/j.bmc.2014.06.041
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 nan None 10.1016/j.bmc.2014.10.016
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 nan None 10.1016/j.ejmech.2016.08.034
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Polyketide synthase Pks13 MIC=<90 0.5 ug ml-1 10.1021/acs.jmedchem.9b00010
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Polyketide synthase Pks13 MIC=<90 4.0 ug ml-1 10.1021/acs.jmedchem.9b00010
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Polyketide synthase Pks13 MIC=<90 8.0 ug ml-1 10.1021/acs.jmedchem.9b00010
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 0.031 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 0.75 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 1.0 ug.mL-1 10.1128/aac.01302-08
Mycolicibacterium aurum Mycolicibacterium aurum MIC90 3460.0 nM 10.1016/j.ejmech.2020.112821
Mycolicibacterium fortuitum Mycolicibacterium fortuitum IC50 1.0 ug.mL-1 10.1128/aac.01380-07
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC50 0.06 ug.mL-1 10.1128/aac.01380-07
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC50 2000.0 nM 10.1016/s0960-894x(99)00251-6
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC90 5000.0 nM 10.1016/s0960-894x(99)00251-6
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Activity nan None 10.1016/j.ejmech.2019.05.081
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 10.0 ug.mL-1 10.1128/aac.01380-07
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 1730.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 2030.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 3130.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IZ 32.0 mm 10.1016/j.ejmech.2006.09.023
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IZ 32.0 mm 10.1016/j.ejmech.2007.01.011
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IZ 32.0 mm 10.1016/j.ejmech.2008.02.038
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IZ 32.0 mm 10.1016/j.ejmech.2009.07.003
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 3125.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 6250.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 15600.0 nM 10.1016/j.bmc.2016.10.009
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC50 1.0 ug.mL-1 10.1128/aac.01380-07
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC50 2000.0 nM 10.1016/s0960-894x(99)00251-6
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC90 3460.0 nM 10.1016/j.ejmech.2020.112821
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC90 4000.0 nM 10.1016/s0960-894x(99)00251-6
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC99 2.16 uM 10.1016/j.bmcl.2007.11.110
Mycolicibacter terrae Mycolicibacter terrae MIC 0.1 ug.mL-1 10.1016/j.bmcl.2016.03.107
Mycolicibacter terrae Mycolicibacter terrae MIC 0.1 ug.mL-1 10.1016/j.bmcl.2016.04.017
Mycolicibacter terrae Mycolicibacter terrae MIC 280.0 nM 10.1016/j.bmc.2016.06.020
Nakaseomyces glabratus Nakaseomyces glabratus IZ 5.0 mm 10.1007/s00044-012-0143-6
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC50 0.008 ug.mL-1 10.1128/aac.01380-07
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Penicillium chrysogenum Penicillium chrysogenum DIZ nan None 10.1016/j.ejmech.2008.07.004
Pichia kudriavzevii Pichia kudriavzevii IZ 5.0 mm 10.1007/s00044-012-0143-6
Plasmodium falciparum Plasmodium falciparum IC50 22.3 ug.mL-1 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 58.6 ug.mL-1 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 113.1 ug.mL-1 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 112500.0 nM 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 113800.0 nM 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 152100.0 nM 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 158100.0 nM 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 195000.0 nM 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 1720000.0 nM 10.1016/j.ejmech.2018.01.039
Plasmodium falciparum Plasmodium falciparum IC50 1770000.0 nM 10.1016/j.ejmech.2018.01.039
Plasmodium yoelii yoelii Plasmodium yoelii yoelii IC50 64.0 ug.mL-1 10.1016/j.ejmech.2018.01.039
Proteus mirabilis Proteus mirabilis MIC 0.05 ug.mL-1 10.1016/s0960-894x(98)00514-9
Proteus mirabilis Proteus mirabilis MIC 0.12 ug.mL-1 10.1007/s00044-010-9338-x
Proteus mirabilis Proteus mirabilis MIC 0.12 ug.mL-1 10.1016/j.ejmech.2010.05.069
Proteus mirabilis Proteus mirabilis MIC 1.0 ug.mL-1 10.1007/s00044-010-9338-x
Proteus mirabilis Proteus mirabilis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2010.05.069
Proteus mirabilis Proteus mirabilis MIC 3.125 ug.mL-1 10.1007/s00044-013-0521-8
Proteus vulgaris Proteus vulgaris IZ 12.0 mm 10.1016/j.ejmech.2006.12.038
Proteus vulgaris Proteus vulgaris IZ 13.0 mm 10.1016/j.ejmech.2006.12.038
Proteus vulgaris Proteus vulgaris IZ 19.0 mm 10.1016/j.ejmech.2008.07.004
Proteus vulgaris Proteus vulgaris IZ 28.0 mm 10.1016/j.ejmech.2006.09.023
Proteus vulgaris Proteus vulgaris IZ 28.0 mm 10.1016/j.ejmech.2007.01.011
Proteus vulgaris Proteus vulgaris IZ 28.0 mm 10.1016/j.ejmech.2008.02.038
Proteus vulgaris Proteus vulgaris IZ 30.0 mm 10.1016/j.ejmech.2009.07.003
Proteus vulgaris Proteus vulgaris IZ 31.0 mm 10.1007/s00044-012-0184-x
Proteus vulgaris Proteus vulgaris MIC 0.05 ug.mL-1 10.1016/s0960-894x(98)00514-9
Proteus vulgaris Proteus vulgaris MIC 0.1 ug.mL-1 10.1021/jm00071a001
Proteus vulgaris Proteus vulgaris MIC 0.25 ug.mL-1 10.1016/j.ejmech.2015.11.027
Proteus vulgaris Proteus vulgaris MIC 3.125 ug.mL-1 10.1007/s00044-013-0521-8
Proteus vulgaris Proteus vulgaris MIC 50.0 ug.mL-1 10.1016/s0960-894x(98)00514-9
Providencia rettgeri Providencia rettgeri MIC 0.1 ug.mL-1 10.1021/jm00398a003
Providencia rettgeri Providencia rettgeri MIC 0.2 ug.mL-1 10.1021/jm00118a026
Providencia rettgeri Providencia rettgeri MIC 0.2 ug.mL-1 10.1021/jm00154a003
Pseudomonas Pseudomonas MIC 0.4 ug.mL-1 10.1021/jm00170a035
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 2.21 uM 10.1016/j.bmc.2009.06.023
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 32.0 % 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 68.0 % 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa ED50 54.5 mg.kg-1 10.1021/jm00071a001
Pseudomonas aeruginosa Pseudomonas aeruginosa FICI 1.0 None 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Fold change 2.5 None 10.1128/aac.00348-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Fold change 8.0 None 10.1128/aac.00348-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Fold change 30.0 None 10.1128/aac.00348-06
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 0.5 ug.mL-1 10.1128/aac.01380-07
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 2.5 mm 10.1016/j.ejmech.2019.02.055
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 15.0 mm 10.1016/j.bmc.2015.04.015
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 16.0 mm 10.1007/s00044-009-9198-4
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 20.83 mm 10.1007/s00044-012-0371-9
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 22.0 mm 10.1007/s00044-011-9811-1
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 22.0 mm 10.1016/j.ejmech.2008.07.004
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 28.0 mm 10.1016/j.ejmech.2009.07.003
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 30.0 mm 10.1016/j.ejmech.2008.02.038
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 43.0 mm 10.1016/j.ejmech.2013.05.028
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 44.0 mm 10.1016/j.ejmech.2006.09.023
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 44.0 mm 10.1016/j.ejmech.2007.01.011
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 1.0 mg/ml 10.1128/aac.00348-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 2.0 mg/ml 10.1128/aac.00348-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 2.0 ug ml-1 10.1039/C7MD00527J
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 512.0 ug ml-1 10.1039/C7MD00527J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.05 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.1 ug.mL-1 10.1021/jm00395a017
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.12 ug.mL-1 10.1007/s00044-011-9655-8
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1016/j.ejmech.2015.11.027
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.256 ug.mL-1 10.1128/aac.00710-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.39 ug.mL-1 10.1021/jm00395a017
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.4 ug.mL-1 10.1021/jm00118a026
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.4 ug.mL-1 10.1021/jm00154a003
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.4 ug.mL-1 10.1021/jm00398a003
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1021/jm00117a005
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.78 ug.mL-1 10.1021/jm00062a007
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.78 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.8 ug.mL-1 10.1128/aac.00464-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1007/s00044-010-9338-x
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1007/s00044-012-0253-1
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1016/j.ejmech.2010.05.069
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1016/S0960-894X(97)00324-7
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.25 ug.mL-1 10.1016/j.ejmech.2008.01.042
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1016/s0960-894x(98)00514-9
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1021/jm00043a018
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1021/jm00070a005
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1021/jm00073a014
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1021/jm00103a011
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1021/jm00168a018
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1021/jm00169a033
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1021/jm00386a005
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.6 ug.mL-1 10.1021/jm00170a035
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.6 ug.mL-1 10.1128/aac.00464-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.95 ug.mL-1 10.1016/j.ejmech.2013.05.028
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1016/S0960-894X(97)00324-7
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1039/C7MD00527J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.048 ug.mL-1 10.1128/aac.00710-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.1 ug.mL-1 10.1016/j.ejmech.2013.05.038
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.1 ug.mL-1 10.1128/aac.00464-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.13 ug.mL-1 10.1021/jm00071a001
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.25 ug.mL-1 10.1007/s00044-011-9918-4
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.25 ug.mL-1 10.1007/s00044-013-0521-8
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.25 ug.mL-1 10.1016/j.ejmech.2008.01.042
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.3 ug.mL-1 10.1128/aac.00464-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.ejmech.2007.09.023
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.ejmech.2008.04.001
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10.0 ug.mL-1 10.1007/s00044-012-0408-0
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10.0 ug.mL-1 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.5 ug.mL-1 10.1016/s0960-894x(98)00514-9
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 25.0 ug.mL-1 10.1007/s00044-011-9840-9
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1007/s00044-012-0253-1
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50.0 ug.mL-1 10.1007/s00044-011-9918-4
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 62.5 ug.mL-1 10.1016/j.ejmech.2007.12.019
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1007/s00044-010-9338-x
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.05.069
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/acsmedchemlett.8b00612
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 80.0 nM 10.1021/jm501552x
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 100.0 ug.mL-1 10.1016/s0960-894x(98)00514-9
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1039/C7MD00527J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 430.0 nM 10.1021/np070483l
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1000.0 ug.mL-1 10.1128/aac.00348-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1250.0 nM 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1560.0 nM 10.1016/j.ejmech.2022.114333
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3900.0 nM 10.1016/j.bmc.2016.10.009
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4000.0 nM 10.1016/j.ejmech.2018.05.021
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4000.0 nM 10.1021/acs.jmedchem.9b00288
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 5200.0 nM 10.1021/jm501552x
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1560000.0 ug.mL-1 10.1021/jm00031a007
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1007/s00044-012-0408-0
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 0.25 ug.mL-1 10.1128/aac.01380-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC>90 1.2 ug ml-1 10.1021/np400145u
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 4.0 ug.mL-1 10.1039/C9MD00120D
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 6920.0 nM 10.1016/j.ejmech.2020.112821
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 62.0 None 10.1021/jm501552x
Pseudomonas oleovorans Pseudomonas oleovorans IZ 17.0 mm 10.1007/s00044-009-9198-4
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Canalicular multispecific organic anion transporter 1 Activity nan None None
Rattus norvegicus GABA-A receptor; anion channel IC50 11000.0 nM 10.1021/jm00062a007
Rattus norvegicus GABA-A receptor; anion channel IC50 100000.0 nM 10.1021/jm00062a007
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma Fu 0.75 None 10.1021/jm901371v
Rattus norvegicus Rattus norvegicus ALB 39300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 195.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 286.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 350.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 363.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 391.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 420.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 46.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 50.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 51.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 60.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 62.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 62.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 75.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 79.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 99.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 99.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 118.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 6100.0 ng.hr.mL-1 10.1016/j.bmc.2012.08.023
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 133.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 145.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 155.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 660.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 670.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 673.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 678.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 683.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 763.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 165.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 179.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 394.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 771.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 1225.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 1308.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CL 14.33 mL.min-1.kg-1 10.1016/j.bmc.2012.08.023
Rattus norvegicus Rattus norvegicus Cmax 30162.99 nM 10.1016/j.bmc.2012.08.023
Rattus norvegicus Rattus norvegicus CO2 22330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 22830000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 80.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 95.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 96.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus F 78.0 % 10.1016/j.bmc.2012.08.023
Rattus norvegicus Rattus norvegicus GLUC 1476.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1556.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1565.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1590.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1623.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1875.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.65 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.03 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 139700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 143700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 114.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 144.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 245.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 380.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 544.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 555.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 16.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10386.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11457.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12358.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13060.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13301.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 16402.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.53 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.83 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.23 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.4 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.65 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 387700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 398800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 400700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 400800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.73 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.7 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.95 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.23 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.35 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.33 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 44.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 48.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 88.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 136.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 180.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 229.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 680.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 986.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1008.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1043.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1187.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1361.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 130.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 142.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1016670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1082000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1227000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1277330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1285330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1340000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.42 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.87 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.45 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.69 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.81 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5160000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5520000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5540000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5630000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5740000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5790000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.73 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.3 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.2 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 1.5 hr 10.1016/j.bmc.2012.08.023
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 21.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 28.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Vd 0.99 L.kg-1 10.1016/j.bmc.2012.08.023
Rattus norvegicus Rattus norvegicus WBC 11480.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12870.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13630.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14070.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14750.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 17430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Solute carrier family 22 member 6 Activity nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 3981.1 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 17782.8 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 23778.1 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 79432.8 nM None
Rhodococcus corynebacterioides Rhodococcus corynebacterioides IZ 25.0 mm 10.1016/j.ejmech.2008.07.004
Rhodotorula mucilaginosa Rhodotorula mucilaginosa DIZ nan None 10.1016/j.ejmech.2008.07.004
Saccharomyces cerevisiae S288c CAAX prenyl protease 1 AC50 1950.0 nM None
Saccharomyces cerevisiae S288c CAAX prenyl protease 2 AC50 100000.0 nM None
Salmonella Salmonella MBC 0.4 uM 10.1016/s0960-894x(99)00251-6
Salmonella Salmonella MIC 400.0 nM 10.1016/s0960-894x(99)00251-6
Salmonella enterica Salmonella enterica Activity nan None 10.1128/aac.00997-08
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica Activity nan None 10.1128/aac.00294-07
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica MIC 0.5 ug.mL-1 10.1128/aac.00294-07
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica MIC 0.75 ug.mL-1 10.1128/aac.00294-07
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica MIC 1.0 ug.mL-1 10.1128/aac.00294-07
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica MIC 1.5 ug.mL-1 10.1128/aac.00294-07
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica MIC 2.0 ug.mL-1 10.1128/aac.00294-07
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica MIC 3.0 ug.mL-1 10.1128/aac.00294-07
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi IZ 31.0 mm 10.1007/s00044-012-0184-x
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium IZ 21.0 mm 10.1016/j.ejmech.2008.07.004
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.05 ug.mL-1 10.1021/jm00070a005
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.0625 ug.mL-1 10.1016/S0960-894X(01)80881-7
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.1 ug.mL-1 10.1021/jm00071a001
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.125 ug.mL-1 10.1016/S0960-894X(01)80881-7
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.13 ug.mL-1 10.1016/S0960-894X(97)00324-7
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.75 ug.mL-1 10.1128/aac.00294-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 2.0 ug.mL-1 10.1128/aac.00121-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 250.0 nM 10.1021/acs.jmedchem.9b00288
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC nan None 10.1128/aac.00121-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC50 0.01 ug.mL-1 10.1128/aac.01380-07
Serratia marcescens Serratia marcescens Activity 1.66 uM 10.1016/j.bmc.2009.06.023
Serratia marcescens Serratia marcescens MIC 0.05 ug.mL-1 10.1128/aac.00631-09
Serratia marcescens Serratia marcescens MIC 0.1 ug.mL-1 10.1128/aac.00631-09
Serratia marcescens Serratia marcescens MIC 0.2 ug.mL-1 10.1021/jm00168a018
Serratia marcescens Serratia marcescens MIC 0.39 ug.mL-1 10.1021/jm00103a011
Serratia marcescens Serratia marcescens MIC 0.78 ug.mL-1 10.1016/s0960-894x(98)00514-9
Serratia marcescens Serratia marcescens MIC 0.78 ug.mL-1 10.1021/jm00071a001
Serratia marcescens Serratia marcescens MIC 3.13 ug.mL-1 10.1128/aac.00631-09
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 12.52 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.08432 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -5.24 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.25 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.1602 None 10.1101/2020.04.03.023846
Shigella Shigella MBC 0.4 uM 10.1016/s0960-894x(99)00251-6
Shigella Shigella MIC 400.0 nM 10.1016/s0960-894x(99)00251-6
Shigella flexneri Shigella flexneri IZ 32.0 mm 10.1016/j.ejmech.2013.05.028
Shigella flexneri Shigella flexneri MIC 0.1 ug.mL-1 10.1021/jm00103a011
Shigella flexneri Shigella flexneri MIC 7.81 ug.mL-1 10.1016/j.ejmech.2013.05.028
Staphylococcus Staphylococcus IZ 21.0 mm 10.1016/j.ejmech.2008.07.004
Staphylococcus aureus DNA gyrase subunit B MIC 0.46 ug.mL-1 10.1021/jm00103a013
Staphylococcus aureus Staphylococcus aureus Activity 1.94 uM 10.1016/j.bmc.2009.06.023
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/jm0703183
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1039/C8MD00257F
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00040-07
Staphylococcus aureus Staphylococcus aureus ED50 0.27 mg mouse-1 10.1021/jm00062a007
Staphylococcus aureus Staphylococcus aureus ED50 8.84 mg.kg-1 10.1021/jm00071a001
Staphylococcus aureus Staphylococcus aureus IC50 10.0 ug.mL-1 10.1128/aac.01380-07
Staphylococcus aureus Staphylococcus aureus Inhibition nan % 10.1021/jm401685f
Staphylococcus aureus Staphylococcus aureus IZ 2.5 mm 10.1016/j.ejmech.2019.02.055
Staphylococcus aureus Staphylococcus aureus IZ 15.0 mm 10.1007/s00044-012-0143-6
Staphylococcus aureus Staphylococcus aureus IZ 15.0 mm 10.1128/aac.00040-07
Staphylococcus aureus Staphylococcus aureus IZ 16.0 mm 10.1007/s00044-009-9198-4
Staphylococcus aureus Staphylococcus aureus IZ 21.2 mm 10.1007/s00044-011-9810-2
Staphylococcus aureus Staphylococcus aureus IZ 21.66 mm 10.1007/s00044-012-0371-9
Staphylococcus aureus Staphylococcus aureus IZ 24.0 mm 10.1016/j.ejmech.2006.09.023
Staphylococcus aureus Staphylococcus aureus IZ 24.0 mm 10.1016/j.ejmech.2007.01.011
Staphylococcus aureus Staphylococcus aureus IZ 24.0 mm 10.1016/j.ejmech.2008.02.038
Staphylococcus aureus Staphylococcus aureus IZ 24.0 mm 10.1016/j.ejmech.2009.07.003
Staphylococcus aureus Staphylococcus aureus IZ 24.3 mm 10.1007/s00044-011-9810-2
Staphylococcus aureus Staphylococcus aureus IZ 25.0 mm 10.1016/j.bmc.2015.04.015
Staphylococcus aureus Staphylococcus aureus IZ 27.0 mm 10.1128/aac.01306-05
Staphylococcus aureus Staphylococcus aureus IZ 31.0 mm 10.1007/s00044-012-0184-x
Staphylococcus aureus Staphylococcus aureus IZ 43.0 mm 10.1016/j.ejmech.2013.05.028
Staphylococcus aureus Staphylococcus aureus MBC 0.5 ug ml-1 10.1039/C7MD00527J
Staphylococcus aureus Staphylococcus aureus MBC 0.5 uM 10.1016/j.ejmech.2018.05.021
Staphylococcus aureus Staphylococcus aureus MBC 0.8 uM 10.1016/s0960-894x(99)00251-6
Staphylococcus aureus Staphylococcus aureus MBC 2.4 uM 10.1016/j.bmcl.2020.127234
Staphylococcus aureus Staphylococcus aureus MBC 2048.0 ug ml-1 10.1039/C7MD00527J
Staphylococcus aureus Staphylococcus aureus MBEC 3.0 uM 10.1016/j.ejmech.2022.114333
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1016/j.bmcl.2010.10.057
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/jm00118a026
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/jm00154a003
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/jm00398a003
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2007.12.019
Staphylococcus aureus Staphylococcus aureus MIC 0.19 ug.mL-1 10.1007/s00044-011-9918-4
Staphylococcus aureus Staphylococcus aureus MIC 0.19 ug.mL-1 10.1021/jm00386a005
Staphylococcus aureus Staphylococcus aureus MIC 0.195 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1016/S0960-894X(97)00054-1
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1016/s0960-894x(98)00514-9
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/jm00062a007
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/jm00168a018
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/jm00395a017
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/np500379f
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1007/s00044-010-9338-x
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1007/s00044-011-9655-8
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1007/s00044-012-0408-0
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2007.09.023
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2008.04.001
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2010.05.069
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/S0960-894X(97)00324-7
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm00117a005
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1039/C7MD00527J
Staphylococcus aureus Staphylococcus aureus MIC 0.31 ug.mL-1 10.1039/C8MD00212F
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1016/s0960-894x(98)00514-9
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00043a018
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00070a005
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00071a001
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00073a014
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00103a011
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00169a033
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00395a017
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1016/j.bmcl.2022.128665
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00118a026
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00154a003
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00170a035
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00398a003
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1007/s00044-012-0253-1
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/S0960-894X(01)80881-7
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/S0960-894X(97)00324-7
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00274-07
Staphylococcus aureus Staphylococcus aureus MIC 0.63 ug.mL-1 10.1016/j.ejmech.2008.01.042
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1016/s0960-894x(98)00514-9
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1021/jm00071a001
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1021/jm00168a018
Staphylococcus aureus Staphylococcus aureus MIC 0.97 ug.mL-1 10.1016/j.ejmech.2013.05.038
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2015.11.027
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 1.25 ug.mL-1 10.1016/j.ejmech.2008.01.042
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.ejmech.2018.08.061
Staphylococcus aureus Staphylococcus aureus MIC 1.562 ug.mL-1 10.1007/s00044-011-9918-4
Staphylococcus aureus Staphylococcus aureus MIC 1.9 ug.mL-1 10.1016/j.ejmech.2007.12.019
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1007/s00044-012-0253-1
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2007.09.023
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2008.04.001
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00274-07
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 2.5 ug.mL-1 10.1016/j.ejmech.2008.01.042
Staphylococcus aureus Staphylococcus aureus MIC 3.1 ug.mL-1 10.1021/jm00170a035
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1007/s00044-013-0521-8
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/j.ejmech.2007.09.025
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1007/s00044-011-9840-9
Staphylococcus aureus Staphylococcus aureus MIC 25.0 ug.mL-1 10.1016/s0960-894x(98)00514-9
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/S0960-894X(97)00054-1
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1007/s00044-010-9338-x
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.05.069
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/S0960-894X(97)00324-7
Staphylococcus aureus Staphylococcus aureus MIC 125.0 nM 10.1016/j.ejmech.2018.05.021
Staphylococcus aureus Staphylococcus aureus MIC 430.0 nM 10.1021/np070483l
Staphylococcus aureus Staphylococcus aureus MIC 500.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1039/C7MD00527J
Staphylococcus aureus Staphylococcus aureus MIC 700.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus aureus Staphylococcus aureus MIC 780.0 nM 10.1016/j.ejmech.2022.114333
Staphylococcus aureus Staphylococcus aureus MIC 800.0 nM 10.1016/s0960-894x(99)00251-6
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 nM 10.1016/j.bmc.2016.10.009
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus aureus Staphylococcus aureus MIC 1250.0 nM 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 1400.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus aureus Staphylococcus aureus MIC 1560.0 nM 10.1016/j.ejmech.2022.114333
Staphylococcus aureus Staphylococcus aureus MIC 2400.0 nM 10.1016/j.bmcl.2020.127234
Staphylococcus aureus Staphylococcus aureus MIC 4096.0 ug.mL-1 10.1016/j.bmc.2006.12.035
Staphylococcus aureus Staphylococcus aureus MIC 25000.0 nM 10.1016/s0960-894x(03)00285-3
Staphylococcus aureus Staphylococcus aureus MIC 100000.0 nM 10.1016/j.ejmech.2018.05.021
Staphylococcus aureus Staphylococcus aureus MIC 177000.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus aureus Staphylococcus aureus MIC 390000.0 ug.mL-1 10.1021/jm00031a007
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1007/s00044-012-0408-0
Staphylococcus aureus Staphylococcus aureus MIC50 0.5 ug.mL-1 10.1128/aac.01380-07
Staphylococcus aureus Staphylococcus aureus MIC50 6.25 ug.mL-1 10.1021/jm00043a018
Staphylococcus aureus Staphylococcus aureus MIC50 6250000.0 ug.mL-1 10.1021/jm00031a007
Staphylococcus aureus Staphylococcus aureus MIC90 0.5 ug.mL-1 10.1039/C9MD00120D
Staphylococcus aureus Staphylococcus aureus MIC90 50.0 ug.mL-1 10.1021/jm00043a018
Staphylococcus aureus Staphylococcus aureus MIC90 1730.0 nM 10.1016/j.ejmech.2020.112821
Staphylococcus aureus Staphylococcus aureus MIC90 50000000.0 ug.mL-1 10.1021/jm00031a007
Staphylococcus aureus Staphylococcus aureus Ratio 16.0 None 10.1039/C8MD00257F
Staphylococcus epidermidis Staphylococcus epidermidis MBC 0.5 ug ml-1 10.1039/C7MD00527J
Staphylococcus epidermidis Staphylococcus epidermidis MBC 2048.0 ug ml-1 10.1039/C7MD00527J
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.2 ug.mL-1 10.1021/jm00168a018
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.2 ug.mL-1 10.1021/np500379f
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1016/S0960-894X(97)00324-7
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1039/C7MD00527J
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.39 ug.mL-1 10.1021/jm00395a017
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.39 ug.mL-1 10.1021/np800811b
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1007/s00044-011-9655-8
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1016/S0960-894X(01)80881-7
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.78 ug.mL-1 10.1021/jm00043a018
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.78 ug.mL-1 10.1021/jm00070a005
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.78 ug.mL-1 10.1021/jm00071a001
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.78 ug.mL-1 10.1021/jm00073a014
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.78 ug.mL-1 10.1021/jm00169a033
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1016/S0960-894X(97)00324-7
Staphylococcus epidermidis Staphylococcus epidermidis MIC 500.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus epidermidis Staphylococcus epidermidis MIC 512.0 ug.mL-1 10.1039/C7MD00527J
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1400.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus epidermidis Staphylococcus epidermidis MIC 780000.0 ug.mL-1 10.1021/jm00031a007
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC 700.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus intermedius Staphylococcus intermedius MIC 89000.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus lugdunensis Staphylococcus lugdunensis MIC 3000.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 0.5 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 1.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 3000.0 nM 10.1021/acs.jnatprod.5b00206
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC50 0.5 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC90 1.0 ug.mL-1 10.1128/aac.01150-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 0.5 ug.mL-1 10.1128/aac.00496-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 1.0 ug.mL-1 10.1016/S0960-894X(01)80881-7
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 1.0 ug.mL-1 10.1128/aac.00496-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2.0 ug.mL-1 10.1016/S0960-894X(01)80881-7
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 3.0 ug.mL-1 10.1128/aac.00496-09
Streptococcus Streptococcus EC50 4106.0 nM None
Streptococcus Streptococcus MBC 1.5 uM 10.1016/s0960-894x(99)00251-6
Streptococcus Streptococcus MIC 1500.0 nM 10.1016/s0960-894x(99)00251-6
Streptococcus agalactiae Streptococcus agalactiae MIC 1.56 ug.mL-1 10.1021/jm00395a017
Streptococcus agalactiae Streptococcus agalactiae MIC 1400.0 nM 10.1021/acs.jnatprod.5b00206
Streptococcus equinus Streptococcus equinus MIC 1.56 ug.mL-1 10.1021/jm00395a017
Streptococcus pneumoniae Streptococcus pneumoniae IC50 40.0 ug.mL-1 10.1128/aac.01380-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.1 ug.mL-1 10.1016/j.bmcl.2010.10.057
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1021/jm00117a005
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.4 ug.mL-1 10.1016/j.bmcl.2022.128665
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.78 ug.mL-1 10.1016/S0960-894X(97)00054-1
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.78 ug.mL-1 10.1021/jm00062a007
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.8 ug.mL-1 10.1021/jm00118a026
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.8 ug.mL-1 10.1021/jm00154a003
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.8 ug.mL-1 10.1021/jm00398a003
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.01380-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC>90 1.1 ug ml-1 10.1021/np400145u
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 2.0 ug.mL-1 10.1039/C9MD00120D
Streptococcus pyogenes Streptococcus pyogenes IZ 0.0 mm 10.1128/aac.00780-09
Streptococcus pyogenes Streptococcus pyogenes IZ 10.0 mm 10.1016/j.ejmech.2006.12.038
Streptococcus pyogenes Streptococcus pyogenes IZ 13.0 mm 10.1016/j.ejmech.2006.12.038
Streptococcus pyogenes Streptococcus pyogenes IZ 17.0 mm 10.1007/s00044-009-9198-4
Streptococcus pyogenes Streptococcus pyogenes MIC 0.39 ug.mL-1 10.1021/jm00168a018
Streptococcus pyogenes Streptococcus pyogenes MIC 0.39 ug.mL-1 10.1021/jm00395a017
Streptococcus pyogenes Streptococcus pyogenes MIC 0.78 ug.mL-1 10.1021/jm00395a017
Streptococcus pyogenes Streptococcus pyogenes MIC 0.8 ug.mL-1 10.1021/jm00118a026
Streptococcus pyogenes Streptococcus pyogenes MIC 0.8 ug.mL-1 10.1021/jm00154a003
Streptococcus pyogenes Streptococcus pyogenes MIC 0.8 ug.mL-1 10.1021/jm00398a003
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1128/aac.00780-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 1.0 ug.mL-1 10.1128/aac.00780-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 4.0 ug.mL-1 10.1128/aac.00780-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 2.0 ug.mL-1 10.1039/C9MD00120D
Streptococcus pyogenes Streptococcus pyogenes MIC90 2.0 ug.mL-1 10.1128/aac.00780-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.00780-09
Streptococcus pyogenes serotype M1 Streptokinase A EC50 3694.0 nM None
Streptococcus sp. 'group A' Streptococcus sp. 'group A' EC50 3033.0 nM None
Streptomyces albus Streptomyces albus IZ 21.0 mm 10.1007/s00044-011-9811-1
Sus scrofa Trypsin AC50 9264.0 nM None
Trichoderma viride Trichoderma viride DIZ nan None 10.1016/j.ejmech.2008.07.004
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 100000.0 nM 10.1016/j.bmc.2009.01.058
Vibrio splendidus Vibrio splendidus MIC 0.25 ug.mL-1 10.1128/aac.00070-07
Vibrio splendidus Vibrio splendidus MIC 0.5 ug.mL-1 10.1128/aac.00070-07
None ADMET AUC 64000.0 ng.hr.mL-1 10.1039/C9MD00120D
None ADMET CL 2.5 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 2.65 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 4.53 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 7.5 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 26.3 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET Cmax 13282.78 nM 10.1039/C9MD00120D
None ADMET DNAUC 32.85 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 218.1 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 297.93 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 407.7 kg.min/L 10.1080/00498250400028197
None ADMET Drugexcretion 46.0 % 10.1016/j.bmc.2012.08.023
None ADMET F 94.36 % 10.1016/s0960-894x(03)00544-4
None ADMET IC50 nan None 10.1016/j.bmcl.2016.04.017
None ADMET Kp 0.8 10^-6 cm/s 10.1016/j.bmc.2022.117146
None ADMET Kp 0.93 10^-6 cm/s 10.1016/j.bmc.2022.117146
None ADMET MRT 11.0 hr 10.1124/dmd.108.020479
None ADMET Papp 0.584 10^-5cm/s 10.1021/acs.jmedchem.1c00230
None ADMET Papp 0.727 10^-5cm/s 10.1021/acs.jmedchem.1c00230
None ADMET Peff 0.37 10'-6 cm/s 10.1016/j.ejmech.2014.09.081
None ADMET Peff 0.8 10'-6 cm/s 10.1016/j.bmc.2016.08.036
None ADMET Peff 0.8 10^-6 cm/s 10.1016/j.bmc.2020.115940
None ADMET Peff 0.8 10^-6 cm/s 10.1016/j.ejmech.2020.112751
None ADMET Peff 0.8 ucm/s 10.1016/j.ejmech.2015.10.007
None ADMET Peff 0.97 10'-6 cm/s 10.1016/j.bmcl.2014.10.025
None ADMET Peff 0.98 10'-6 cm/s 10.1016/j.bmc.2014.07.053
None ADMET Peff 0.98 ucm/s 10.1016/j.ejmech.2015.10.007
None ADMET Peff 1.0 10'-6 cm/s 10.1016/j.bmc.2016.08.036
None ADMET Peff 1.2 ucm/s 10.1021/jm201463v
None ADMET permeability 0.11 10^-6 cm/s 10.1016/j.ejmech.2022.114354
None ADMET permeability 0.3 10'-6 cm/s 10.1021/jm801292b
None ADMET permeability 0.37 ucm/s 10.1016/j.bmc.2013.09.050
None ADMET permeability 0.4 10^-6 cm/s 10.1016/j.ejmech.2022.114210
None ADMET permeability 0.54 10^-6 cm/s 10.1016/j.ejmech.2020.112492
None ADMET permeability 0.7 ucm/s 10.1016/j.ejmech.2011.12.016
None ADMET permeability 0.8 10'-6 cm/s 10.1016/j.ejmech.2015.03.040
None ADMET permeability 0.8 10'-6 cm/s 10.1021/jm900859q
None ADMET permeability 0.8 10^-6 cm/s 10.1016/j.ejmech.2020.112492
None ADMET permeability 0.8 10^-6 cm/s 10.1016/j.ejmech.2021.113554
None ADMET permeability 0.8 10^-6 cm/s 10.1016/j.ejmech.2021.113735
None ADMET permeability 0.8 10^-6 cm/s 10.1039/c9md00441f
None ADMET permeability 0.8 ucm/s 10.1016/j.bmc.2013.09.050
None ADMET permeability 0.8 ucm/s 10.1016/j.bmc.2016.02.023
None ADMET permeability 0.8 ucm/s 10.1016/j.bmc.2016.09.050
None ADMET permeability 0.8 ucm/s 10.1016/j.ejmech.2013.12.008
None ADMET permeability 0.98 10'-6 cm/s 10.1016/j.ejmech.2014.07.021
None ADMET permeability 1.1 ucm/s 10.1016/j.ejmech.2012.09.044
None ADMET permeability 1.12 ucm/s 10.1016/j.bmc.2016.09.050
None ADMET permeability 1.21 10'-6 cm/s 10.1016/j.ejmech.2015.03.040
None ADMET permeability 1.3 10'-6 cm/s 10.1016/j.ejmech.2011.10.040
None ADMET permeability 1.31 ucm/s 10.1016/j.bmc.2016.02.023
None ADMET permeability 1.9 10^-6 cm/s 10.1016/j.ejmech.2021.113441
None ADMET permeability 2.3 10'-6 cm/s 10.1021/jm900628z
None ADMET permeability 2.3 ucm/s 10.1016/j.ejmech.2011.03.003
None ADMET permeability 2.6 10'-6 cm/s 10.1021/jm900859q
None ADMET permeability 3.1 10'-6 cm/s 10.1021/jm900859q
None ADMET permeability 4.7 10'-6 cm/s 10.1021/jm901421c
None ADMET permeability nan None 10.1021/acs.jmedchem.1c01942
None ADMET PPB 25.0 % 10.1128/aac.00971-08
None ADMET PPB 40.0 % 10.1039/C9MD00120D
None ADMET Ratio 1.0 None 10.1128/aac.00414-06
None ADMET Ratio 1.0 None 10.1128/aac.00971-08
None ADMET Ratio 1.25 None 10.1021/acs.jmedchem.1c00230
None ADMET RatioAUC/MIC 2.0 None 10.1128/aac.00414-06
None ADMET Solubility 2300.0 ug.mL-1 10.1021/jm00062a007
None ADMET T1/2 6.0 hr 10.1039/C9MD00120D
None ADMET T1/2 8.9 hr 10.1124/dmd.108.020479
None ADMET Vdss 1.15 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 1.6 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 1.6 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 1.66 mL/min/kg 10.1124/dmd.105.006619
None ADMET Vdss 1.78 L.kg-1 10.1124/dmd.105.006619
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 1.2 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.5 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 6.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 1.2 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 1.9 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 2.1 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Molecular identity unknown FC 2.3 None 10.1128/aac.00532-09
None Molecular identity unknown FC 2.7 None 10.1128/aac.00532-09
None Molecular identity unknown FC 3.1 None 10.1128/aac.00532-09
None Molecular identity unknown FC 4.3 None 10.1128/aac.00532-09
None Molecular identity unknown FC 6.1 None 10.1128/aac.00532-09
None Molecular identity unknown FC 11.7 None 10.1128/aac.00532-09
None NON-PROTEIN TARGET Activity 8.0 ug ml-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET Activity 40.6 % 10.1128/aac.00898-09
None NON-PROTEIN TARGET Activity 84.2 % 10.1128/aac.00898-09
None NON-PROTEIN TARGET Fu 0.75 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET GI nan None 10.1016/j.ejmech.2016.06.042
None NON-PROTEIN TARGET Hepatotoxicity (acute) 18.2 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 42.2 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 61.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET MIC 0.03 ug.mL-1 10.1128/aac.00121-09
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.00121-09
None NON-PROTEIN TARGET MIC 0.2 ug.mL-1 10.1021/jm00103a013
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00477-09
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00121-09
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.01339-09
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00121-09
None NON-PROTEIN TARGET MIC 5.6 ug.mL-1 10.1016/j.bmcl.2012.05.026
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00477-09
None NON-PROTEIN TARGET MIC 128.0 ug.mL-1 10.1128/aac.00532-09
None NON-PROTEIN TARGET MIC 15600.0 nM 10.1016/j.bmc.2016.10.009
None NON-PROTEIN TARGET MIC nan None 10.1128/aac.00121-09
None NON-PROTEIN TARGET MIC50 0.25 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC50 0.8 ug.mL-1 10.1128/aac.01380-07
None NON-PROTEIN TARGET MIC50 8.0 ug.mL-1 10.1128/aac.01380-07
None NON-PROTEIN TARGET MIC50 16.0 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC50 16.0 ug.mL-1 10.1128/aac.01380-07
None NON-PROTEIN TARGET MIC50 nan None 10.1128/aac.01380-07
None NON-PROTEIN TARGET MIC90 32.0 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC90 64.0 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET Potency 11.9 nM None
None NON-PROTEIN TARGET Potency 167.7 nM None
None NON-PROTEIN TARGET Potency 334.7 nM None
None NON-PROTEIN TARGET Potency 8912.5 nM None
None NON-PROTEIN TARGET Potency 10000.0 nM None
None NON-PROTEIN TARGET Potency 11875.4 nM None
None NON-PROTEIN TARGET Potency 12589.3 nM None
None NON-PROTEIN TARGET Potency 13324.4 nM None
None NON-PROTEIN TARGET Potency 14125.4 nM None
None NON-PROTEIN TARGET Potency 14950.2 nM None
None NON-PROTEIN TARGET Potency 16774.4 nM None
None No relevant target CLogP 5.12 None 10.1021/jm00062a007
None No relevant target LogD7.4 -0.45 None 10.6019/CHEMBL3301361
None No relevant target Peff 0.36 10'-6 cm/s 10.1016/j.ejmech.2017.07.055
None No relevant target Peff 0.37 10'-6 cm/s 10.1016/j.ejmech.2018.12.013
None No relevant target Peff 0.6 10'-6 cm/s 10.1016/j.ejmech.2018.07.056
None No relevant target Peff 0.8 10'-6 cm/s 10.1016/j.ejmech.2017.07.055
None No relevant target Peff 0.8 10'-6 cm/s 10.1016/j.ejmech.2018.01.055
None No relevant target Peff 0.8 10'-6 cm/s 10.1016/j.ejmech.2018.07.056
None No relevant target Peff 0.8 10'-6 cm/s 10.1016/j.ejmech.2018.12.013
None No relevant target Peff 1.1 10'-6 cm/s 10.1016/j.bmc.2017.05.027
None No relevant target Peff 1.1 10'-6 cm/s 10.1016/j.ejmech.2018.01.055
None No relevant target permeability 0.4 10'-6 cm/s 10.1016/j.ejmech.2017.06.060
None No relevant target permeability 0.4 10'-6 cm/s 10.1016/j.ejmech.2017.08.025
None No relevant target permeability 0.4 ucm/s 10.1021/jm500065f
None No relevant target permeability 0.8 10'-6 cm/s 10.1016/j.bmc.2016.06.045
None No relevant target permeability 0.8 10'-6 cm/s 10.1016/j.ejmech.2017.02.034
None No relevant target permeability 0.8 10'-6 cm/s 10.1016/j.ejmech.2017.02.042
None No relevant target permeability 0.8 10'-6 cm/s 10.1016/j.ejmech.2017.02.045
None No relevant target permeability 0.8 10'-6 cm/s 10.1016/j.ejmech.2017.06.060
None No relevant target permeability 0.8 10'-6 cm/s 10.1016/j.ejmech.2017.08.025
None No relevant target permeability 0.8 10'-6 cm/s 10.1016/j.ejmech.2019.07.051
None No relevant target permeability 0.8 ucm/s 10.1016/j.ejmech.2018.01.007
None No relevant target permeability 1.0 10'-6 cm/s 10.1016/j.ejmech.2019.07.051
None No relevant target permeability 1.27 10'-6 cm/s 10.1016/j.bmc.2017.05.027
None No relevant target permeability 1.32 10'-6 cm/s 10.1016/j.ejmech.2017.02.045
None No relevant target permeability 2.3 10'-6 cm/s 10.1016/j.ejmech.2017.02.034
None No relevant target pKa 8.31 None 10.1007/s11095-013-1232-z
None No relevant target pKa_A1 6.08 None 10.6019/CHEMBL3301361
None No relevant target pKa_B1 8.1 None 10.6019/CHEMBL3301361
None No relevant target Solubility 19600.0 ug.mL-1 10.1016/j.bmc.2010.08.003
None Nucleic Acid IC50 0.59 ug.mL-1 10.1021/jm00169a033
None Phospholipidosis Maximum test concentration that did not exhibit cytotoxicity 50.0 uM None
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Phospholipidosis Phospholipidosis as % of positive control 0.3 % None
None Unchecked Ac50 3.981 uM None
None Unchecked Ac50 10.0 uM None
None Unchecked Ac50 11.22 uM None
None Unchecked Ac50 12.59 uM None
None Unchecked AC50 3981.1 nM None
None Unchecked AC50 10000.0 nM None
None Unchecked AC50 11220.2 nM None
None Unchecked AC50 12590.0 nM None
None Unchecked Activity nan None 10.1128/aac.00274-07
None Unchecked CC25 0.5 uM 10.1128/aac.01380-07
None Unchecked CC25 1.5 uM 10.1128/aac.01380-07
None Unchecked CC25 3.0 uM 10.1128/aac.01380-07
None Unchecked CC25 14.0 uM 10.1128/aac.01380-07
None Unchecked CC25 nan None 10.1128/aac.01380-07
None Unchecked Hepatotoxicity (acute) 11.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 6.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 230.0 nM None
None Unchecked IC50 310.0 nM None
None Unchecked IC50 390.0 nM None
None Unchecked IC50 560.0 nM None
None Unchecked IC50 800.0 nM None
None Unchecked IC50 1730.0 nM None
None Unchecked IC50 3000.0 nM 10.1128/aac.01380-07
None Unchecked IC50 4000.0 nM 10.1128/aac.01380-07
None Unchecked IC50 7000.0 nM 10.1128/aac.01380-07
None Unchecked IC50 8000.0 nM 10.1128/aac.01380-07
None Unchecked IC50 11000.0 nM 10.1128/aac.01380-07
None Unchecked IC50 20000.0 nM 10.1128/aac.01380-07
None Unchecked IC50 25000.0 nM 10.1128/aac.01380-07
None Unchecked IC50 nan None 10.1016/j.bmc.2015.02.032
None Unchecked IC50 nan None 10.1016/j.ejmech.2016.06.042
None Unchecked IC50 nan None 10.1128/aac.01380-07
None Unchecked IC50 nan None None
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.112821
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ki nan None None
None Unchecked MIC 0.4 ug.mL-1 10.1021/jm00170a035
None Unchecked Potency 316.2 nM None
None Unchecked Potency 1158.2 nM None
None Unchecked Ratio 4.0 None 10.1021/acs.jmedchem.9b00288
None Unchecked Ratio 7.0 None 10.1128/aac.01380-07
None Unchecked Ratio 8.0 None 10.1021/jm500432n

Metabolism Information