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Verapamil

AlkaPlorer ID: AK321938

Synonym: None

IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile

Structure

SMILES: COC1=CC=C(CCN(C)CCCC(C#N)(C2=CC=C(OC)C(OC)=C2)C(C)C)C=C1OC

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InChI: InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3

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InChIKey: SGTNSNPWRIOYBX-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 454.6110000000002

TPSA？: 63.95

MolLogP？: 5.093080000000005

Number of H-Donors: 0

Number of H-Acceptors: 6

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Canis lupus familiaris Canis familiaris ID50 0.001 M 10.1021/jm00360a001
Canis lupus familiaris Canis familiaris Inhibition 93.0 % 10.1021/jm00119a026
Canis lupus familiaris MDCK logPapp -4.57 None 10.1021/jm901846t
Canis lupus familiaris MDCK-II EC50 5100.0 nM 10.1016/j.bmc.2008.09.065
Canis lupus familiaris MDCK-II IC50 100000.0 nM 10.1021/acs.jmedchem.1c00246
Cavia porcellus Aorta Activity 95.0 % 10.1021/acs.jmedchem.6b00030
Cavia porcellus Aorta IC50 380.0 nM 10.1021/acs.jmedchem.6b00030
Cavia porcellus Cavia porcellus Activity 84.0 % 10.1021/jm980440p
Cavia porcellus Cavia porcellus Activity 94.0 % 10.1021/jm980440p
Cavia porcellus Cavia porcellus Activity 95.0 % 10.1021/jm980440p
Cavia porcellus Cavia porcellus C175 0.1 uM 10.1021/jm00398a023
Cavia porcellus Cavia porcellus Ca2+ antagonistic activity 79.0 % 10.1021/jm00111a043
Cavia porcellus Cavia porcellus Change 84.0 % 10.1021/jm00056a003
Cavia porcellus Cavia porcellus Change 94.0 % 10.1021/jm00056a003
Cavia porcellus Cavia porcellus Contraction 6.8 % 10.1021/jm010576e
Cavia porcellus Cavia porcellus Control 35.0 % 10.1021/jm00398a023
Cavia porcellus Cavia porcellus CPP 48.8 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus CPP 49.7 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus CPP 50.3 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus CPP 51.7 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus EC30 0.07 uM 10.1021/jm980440p
Cavia porcellus Cavia porcellus EC30 0.2 ug ml-1 10.1021/jm00185a013
Cavia porcellus Cavia porcellus EC30 0.24 ug ml-1 10.1021/jm00185a013
Cavia porcellus Cavia porcellus EC30 6.5 ug ml-1 10.1021/jm00185a013
Cavia porcellus Cavia porcellus EC50 610.0 nM 10.1021/jm980440p
Cavia porcellus Cavia porcellus ED30 0.07 uM 10.1021/jm00056a003
Cavia porcellus Cavia porcellus ED50 0.61 uM 10.1021/jm00056a003
Cavia porcellus Cavia porcellus HR 188.0 beats min-1 10.1021/jm00149a014
Cavia porcellus Cavia porcellus HR 200.3 beats min-1 10.1021/jm00149a014
Cavia porcellus Cavia porcellus HR 203.8 beats min-1 10.1021/jm00149a014
Cavia porcellus Cavia porcellus HR 210.0 beats min-1 10.1021/jm00149a014
Cavia porcellus Cavia porcellus IC50 35.0 nM 10.1021/jm00169a011
Cavia porcellus Cavia porcellus IC50 100.0 nM 10.1021/jm00400a006
Cavia porcellus Cavia porcellus IC50 210.0 nM 10.1021/jm00169a011
Cavia porcellus Cavia porcellus IC50 380.0 nM 10.1021/jm00056a003
Cavia porcellus Cavia porcellus IC50 380.0 nM 10.1021/jm980440p
Cavia porcellus Cavia porcellus IC50 620.0 nM 10.1021/jm00169a011
Cavia porcellus Cavia porcellus IC50 700.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus IC50 800.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus IC50 10000.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus IC50 16000.0 nM 10.1021/jm00382a017
Cavia porcellus Cavia porcellus ID50 5.0 M 10.1021/jm00360a001
Cavia porcellus Cavia porcellus Inhibition 37.9 % 10.1021/jm00087a017
Cavia porcellus Cavia porcellus Inhibition 49.9 % 10.1021/jm00087a017
Cavia porcellus Cavia porcellus Inhibition 63.0 % 10.1021/jm00087a017
Cavia porcellus Cavia porcellus Inhibition 77.8 % 10.1021/jm00087a017
Cavia porcellus Cavia porcellus Inhibition 95.0 % 10.1021/jm00056a003
Cavia porcellus Cavia porcellus Inhibition 100.0 % 10.1021/jm00087a017
Cavia porcellus Cavia porcellus Kb 20.0 nM 10.1021/jm00109a010
Cavia porcellus Cavia porcellus Log B/F 0.114 None 10.1021/jm00179a017
Cavia porcellus Cavia porcellus LVP 13.0 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus LVP 21.5 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus LVP 24.0 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus LVP 25.7 mmHg 10.1021/jm00149a014
Cavia porcellus Cavia porcellus Negative chronotropic activity 94.0 % 10.1021/jm00111a043
Cavia porcellus Cavia porcellus Negative ionotropic activity 60.0 % 10.1021/jm00111a043
Cavia porcellus Cavia porcellus P (Ei) 0.001 None 10.1021/jm00398a023
Cavia porcellus Ileum Inhibition 0.25 % 10.1021/np800041t
Cavia porcellus Ileum Inhibition 0.28 % 10.1021/np800041t
Cavia porcellus Left atrium Activity 84.0 % 10.1021/acs.jmedchem.6b00030
Cavia porcellus Left atrium EC50 610.0 nM 10.1021/acs.jmedchem.6b00030
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 100.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 100.0 nM 10.1093/cvr/cvr044
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 164.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 600.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 790.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 940.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 1500.0 nM None
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 1800.0 nM None
Chlorocebus sabaeus Vero IC50 57.3 ug.mL-1 10.1021/jm500853v
Cricetulus griseus CHO Activity 61.03 % 10.1016/j.bmc.2010.02.040
Cricetulus griseus CHO IC50 560.0 nM 10.1039/C8MD00382C
Cricetulus griseus CHO IC50 nan None 10.1016/j.bmcl.2016.01.052
Cricetulus griseus CHRC5 cell line EC50 1200.0 nM 10.1016/0960-894X(95)00426-T
Cricetulus griseus CHRC5 cell line EC50 3000.0 nM 10.1021/jm00013a017
Cricetulus griseus DC3F/AD Fold reversion 3.0 None 10.1021/jm00091a017
Cricetulus griseus DC3F/AD Fold reversion 34.0 None 10.1021/jm00091a017
Cricetulus griseus DC3F/AD Increase 2.6 None 10.1021/jm00091a017
Cricetulus griseus DC3F/AD Increase 7.5 None 10.1021/jm00091a017
Cricetulus griseus DC3F/AD Viability 39.0 % 10.1021/jm00091a017
Cricetulus griseus DC3F/AD Viability 43.0 % 10.1021/jm00091a017
Cryptosporidium parvum Cryptosporidium parvum IC50 nan None 10.1016/j.bmc.2010.01.068
Danio rerio Danio rerio Activity nan None 10.1038/nchembio.79
Drosophila Drosophila Activity nan None 10.1038/nchembio.79
Entamoeba histolytica Entamoeba histolytica IC50 nan None 10.1016/j.bmc.2010.01.068
Escherichia coli Escherichia coli Inhibition nan % 10.1016/j.bmc.2012.05.025
Felis catus Felis catus ID50 1e-05 M 10.1021/jm00360a001
Homo sapiens A2780 Activity 53.0 % 10.1016/j.bmcl.2007.04.030
Homo sapiens A2780 Activity 82.0 % 10.1016/j.bmcl.2007.04.030
Homo sapiens A2780 Activity 93.0 % 10.1016/j.bmcl.2007.04.030
Homo sapiens A2780 Control 350.0 % 10.1016/s0960-894x(99)00647-2
Homo sapiens A2780/Taxol IC50 18.8 nM 10.1016/j.bmcl.2018.11.023
Homo sapiens A2780/Taxol Ratio IC50 211.0 None 10.1016/j.bmcl.2018.11.023
Homo sapiens A2780/Taxol Survival 85.34 % 10.1016/j.bmcl.2018.11.023
Homo sapiens A549 Activity nan None 10.1016/j.ejmech.2022.114822
Homo sapiens A549 IC50 127090.0 nM 10.1016/j.bmcl.2014.12.088
Homo sapiens A549/TR Activity nan None 10.1016/j.ejmech.2022.114822
Homo sapiens A549/TR Activity nan None 10.1021/acs.jmedchem.2c01306
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adrenergic receptor alpha Kd 1000.0 nM 10.1021/jm00387a008
Homo sapiens Alpha-1a adrenergic receptor AC50 1334.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 4340.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 28419.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 2293.5 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 2317.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 579.0 nM None
Homo sapiens Alpha-2a adrenergic receptor Ki 217.0 nM None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 4300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Ataxin-2 Potency 17782.8 nM None
Homo sapiens Ataxin-2 Potency 28183.8 nM None
Homo sapiens ATP-binding cassette sub-family G member 2 EC50 900.0 nM 10.1016/j.ejmech.2019.111655
Homo sapiens ATP-binding cassette sub-family G member 2 EC50 37300.0 nM 10.1016/j.bmc.2014.09.023
Homo sapiens ATP-binding cassette sub-family G member 2 EC50 nan None 10.1016/j.ejmech.2019.03.054
Homo sapiens ATP-binding cassette sub-family G member 2 FC 1.0 None 10.1016/j.ejmech.2021.113317
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 1193.38 nM 10.1016/j.ejmech.2021.113317
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 50000.0 nM 10.1124/mol.65.6.1485
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 524807.46 nM 10.1016/j.bmc.2008.07.034
Homo sapiens ATP-binding cassette sub-family G member 2 Inhibition nan % 10.1021/acs.jmedchem.1c00779
Homo sapiens ATP-binding cassette sub-family G member 2 Ratio nan None 10.1016/j.bmc.2010.06.004
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Beta-secretase 1 Kd nan None 10.1016/j.ejmech.2017.06.020
Homo sapiens Bile acid receptor FXR AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 47999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 79100.0 nM 10.1023/a:1023278211849
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 178900.0 nM 10.1023/a:1023278211849
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Breast cancer cell line EC50 1200.0 nM 10.1021/jm010126m
Homo sapiens Breast cancer cell line EC50 2400.0 nM 10.1021/jm010126m
Homo sapiens Breast cancer cell line Ratio 16.0 None 10.1021/jm010126m
Homo sapiens Breast cancer cell line Ratio 21.2 None 10.1021/jm010126m
Homo sapiens Breast cancer cell line Relative potency 9.2 None 10.1021/jm010126m
Homo sapiens Breast cancer cell line Relative potency 16.1 None 10.1021/jm010126m
Homo sapiens Breast cancer cell line Relative resistance 1.0 None 10.1021/jm010126m
Homo sapiens Caco-2 Activity 20.0 % 10.1016/j.ejmech.2022.114231
Homo sapiens Caco-2 Activity 52.0 uM 10.1021/jm060639z
Homo sapiens Caco-2 IC10 24.9 uM 10.1016/j.bmc.2007.01.024
Homo sapiens Caco-2 logPapp -4.58 None 10.1016/j.bmc.2009.08.022
Homo sapiens Caco-2 logPapp -4.34 None 10.1016/j.bmc.2011.03.011
Homo sapiens Caco-2 Papp 12.0 10^-6 cm/s 10.1016/j.bmcl.2008.01.109
Homo sapiens Caco-2 Papp 591.0 nm/s 10.1016/j.bmc.2007.09.039
Homo sapiens Caco-2 Papp 591.0 nm/s 10.1016/j.bmc.2008.01.055
Homo sapiens Caco-2 Papp 687.0 nm/s 10.1016/j.bmc.2007.09.039
Homo sapiens Caco-2 Papp 687.0 nm/s 10.1016/j.bmc.2008.01.055
Homo sapiens Caco-2 permeability nan None 10.1016/j.bmc.2011.03.011
Homo sapiens Caco-2 Ratio 1.2 None 10.1016/j.bmc.2007.09.039
Homo sapiens Caco-2 Ratio 1.2 None 10.1016/j.bmc.2008.01.055
Homo sapiens Caco-2 Ratio 1.2 None 10.1021/jm701267q
Homo sapiens Caco-2 Ratio 2.0 None 10.1016/j.ejmech.2014.02.051
Homo sapiens Caco-2 Ratio 18.0 None 10.1016/j.ejmech.2019.03.054
Homo sapiens Caco-2 Ratio 18.0 None 10.1016/j.ejmech.2019.111655
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 56.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 5000.0 nM 10.1016/j.ejmech.2021.113317
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 200000.0 nM 10.1016/j.bmcl.2008.07.127
Homo sapiens Canalicular multispecific organic anion transporter 1 Ki nan None 10.1023/a:1016192413308
Homo sapiens Canalicular multispecific organic anion transporter 1 Ratio nan None 10.1016/j.bmc.2010.06.004
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM ED50 0.35 uM l-1 10.1021/jm960384x
Homo sapiens CCRF-CEM ED50 0.54 uM l-1 10.1021/jm960384x
Homo sapiens CCRF-CEM ED50 45.0 nM 10.1021/jm00014a031
Homo sapiens CCRF-CEM ED50 3400.0 nM 10.1021/jm00014a031
Homo sapiens CCRF-CEM RP 31.0 None 10.1021/jm00014a031
Homo sapiens CCRF-CEM Uptake 79.0 % 10.1021/jm00014a031
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 Activity nan None 10.1021/acs.jmedchem.1c01093
Homo sapiens Cytochrome P450 1A2 Activity nan None None
Homo sapiens Cytochrome P450 1A2 IC50 30000.0 nM 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 1A2 IC50 50000.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2B6 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 Activity nan None 10.1021/acs.jmedchem.1c01093
Homo sapiens Cytochrome P450 2C19 IC50 21800.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 2C19 IC50 30000.0 nM 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C8 IC50 30000.0 nM 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 2C8 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C8 Ki 17500.0 nM 10.2174/138920005774330639
Homo sapiens Cytochrome P450 2C8 Kinact 0.065 min-1 10.2174/138920005774330639
Homo sapiens Cytochrome P450 2C9 Activity nan None 10.1021/acs.jmedchem.1c01093
Homo sapiens Cytochrome P450 2C9 IC50 30000.0 nM 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 2C9 IC50 50000.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 Activity nan None 10.1021/acs.jmedchem.1c01093
Homo sapiens Cytochrome P450 2D6 IC50 30000.0 nM 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 2D6 IC50 43300.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 2J2 Activity 1.3 % 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 2J2 Activity 69.1 % 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 2J2 IC50 22000.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 3A4 Activity nan None 10.1021/acs.jmedchem.1c01093
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 CL 2.36 uL/min/pmol 10.1021/acs.jmedchem.7b01465
Homo sapiens Cytochrome P450 3A4 IC50 11.0 nM 10.1021/acs.jmedchem.1c01498
Homo sapiens Cytochrome P450 3A4 IC50 4700.0 nM 10.1021/jm021012t
Homo sapiens Cytochrome P450 3A4 IC50 5700.0 nM 10.1021/acs.jmedchem.1c01452
Homo sapiens Cytochrome P450 3A4 IC50 8193.0 nM 10.1021/acs.jmedchem.8b00335
Homo sapiens Cytochrome P450 3A4 IC50 12000.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 3A4 IC50 17600.0 nM 10.1124/dmd.111.043505
Homo sapiens Cytochrome P450 3A4 IC50 21330.0 nM 10.1021/acs.jmedchem.0c01741
Homo sapiens Cytochrome P450 3A4 IC50 76032.63 nM 10.1016/j.ejmech.2008.12.004
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition 51.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/acs.jmedchem.0c01741
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/acs.jmedchem.1c01498
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1124/dmd.111.038208
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 11095.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 4400.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 202.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 400.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 186.0 nM None
Homo sapiens Dopamine D3 receptor Ki 63.0 nM None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens ECa-109 cell line Activity 0.12 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 0.48 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 2.65 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 7.92 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 10.5 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 20.3 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 68.8 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 89.3 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 95.6 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line FC 10.1 None 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line IC50 679.0 nM 10.1021/acs.jmedchem.2c02061
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GC3/Cl Control 178.0 % 10.1021/jm00096a009
Homo sapiens GC3/Cl Control 238.0 % 10.1021/jm00096a009
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon-like peptide 1 receptor Potency 14125.4 nM None
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens H4 Activity 70.15 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 71.28 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 83.96 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 94.39 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 97.84 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 103.33 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 114.92 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 132.44 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 168.55 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 200.63 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 238.6 % 10.1073/pnas.0709695104
Homo sapiens HCT-116 IC50 4.0 nM 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 IC50 20.0 nM 10.1016/j.bmcl.2004.10.002
Homo sapiens HCT-116 IC50 20.0 nM 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 IC50 130.0 nM 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 IC50 300.0 nM 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 IC50 400.0 nM 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 IC50 500.0 nM 10.1016/j.bmcl.2004.10.002
Homo sapiens HCT-116 Reversion 10.0 % 10.1016/j.bmcl.2004.10.002
Homo sapiens HCT-116 Reversion 10.0 % 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Reversion 15.0 % 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Reversion 20.0 % 10.1016/j.bmcl.2004.10.002
Homo sapiens HCT-116 Reversion 25.0 % 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Reversion 30.0 % 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Sensitivity 2.0 None 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Sensitivity 3.0 None 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Sensitivity 4.0 None 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Sensitivity 10.0 None 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Sensitivity 17.0 None 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-116 Sensitivity 20.0 None 10.1016/s0960-894x(03)00294-4
Homo sapiens HCT-15 Activity nan None 10.1021/np100429s
Homo sapiens HCT-8 Activity nan None 10.1016/j.ejmech.2022.114822
Homo sapiens HEK293 CC50 280000.0 nM 10.1039/C7MD00424A
Homo sapiens HEK293 CC50 nan None 10.1016/j.ejmech.2017.06.020
Homo sapiens HEK293 FC 0.8 None 10.1016/j.ejmech.2016.08.044
Homo sapiens HEK293 FC 0.9 None 10.1021/acs.jmedchem.7b01340
Homo sapiens HEK293 FC 1.04 None 10.1016/j.ejmech.2016.08.044
Homo sapiens HEK293 FC 1.19 None 10.1021/acs.jmedchem.1c01498
Homo sapiens HEK293 FC 1.37 None 10.1016/j.ejmech.2016.08.044
Homo sapiens HEK293 FC 1.49 None 10.1016/j.ejmech.2016.08.044
Homo sapiens HEK293 FC 1.82 None 10.1016/j.ejmech.2016.08.044
Homo sapiens HEK293 FC 8.81 None 10.1021/acs.jmedchem.1c01498
Homo sapiens HEK293 FC 9.54 None 10.1016/j.ejmech.2016.08.044
Homo sapiens HEK293 IC50 1620.0 nM 10.1021/acs.jmedchem.1c01498
Homo sapiens HEK293 IC50 10370.0 nM 10.1021/acs.jmedchem.1c01498
Homo sapiens HEK293 IC50 50000.0 nM 10.1016/j.ejmech.2016.08.044
Homo sapiens HEK293 IC50 101260.0 nM 10.1016/j.ejmech.2018.01.027
Homo sapiens HEK293 Potency 23099.9 nM None
Homo sapiens HEK293 Survival 80.0 % 10.1021/acs.jmedchem.7b01340
Homo sapiens HEK-293T Activity nan None 10.1016/j.ejmech.2022.114822
Homo sapiens HEK-293T IC50 32040.0 nM 10.1016/j.ejmech.2022.114822
Homo sapiens HEK-293T Ratio IC50 0.84 None 10.1016/j.bmc.2018.10.027
Homo sapiens HEK-293T Ratio IC50 0.89 None 10.1016/j.bmc.2018.10.027
Homo sapiens HEK-293T Ratio IC50 1.07 None 10.1016/j.bmc.2018.10.027
Homo sapiens HeLa IC50 50000.0 nM 10.1016/j.ejmech.2020.112422
Homo sapiens HeLa S3 IC50 50000.0 nM 10.1016/j.ejmech.2016.08.044
Homo sapiens Hepatocyte CL 14.66 mL.min-1.kg-1 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte CL 77.1 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
Homo sapiens Hepatocyte logCL 1.166 None 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte Stability 3.9 % 10.1021/jm901893x
Homo sapiens HepG2 Activity nan None 10.1016/j.bmc.2018.11.010
Homo sapiens HepG2 IC50 65200.0 nM 10.1021/acs.jmedchem.2c01170
Homo sapiens HepG2 IC50 138420.0 nM 10.1021/acs.jmedchem.6b00605
Homo sapiens HERG AC50 1718.1 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 10.0 nM 10.1021/jm400856t
Homo sapiens HERG IC50 141.25 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 141.25 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 141.25 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 141.25 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 143.0 nM 10.1016/s0960-894x(03)00196-3
Homo sapiens HERG IC50 143.0 nM 10.1021/jm0208875
Homo sapiens HERG IC50 143.0 nM 10.1093/cvr/cvr044
Homo sapiens HERG IC50 144.54 nM 10.1016/j.bmcl.2005.01.008
Homo sapiens HERG IC50 144.54 nM 10.1016/j.ejmech.2008.11.009
Homo sapiens HERG IC50 200.0 nM 10.1021/acsmedchemlett.1c00328
Homo sapiens HERG IC50 400.0 nM 10.1021/acs.jmedchem.0c00168
Homo sapiens HERG IC50 530.0 nM 10.1016/j.bmc.2017.07.058
Homo sapiens HERG IC50 3100.0 nM 10.1016/j.bmcl.2004.06.070
Homo sapiens HERG IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Inhibition 91.0 % 10.1021/acs.jmedchem.1c00497
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 3213.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 2590.0 nM None
Homo sapiens Histamine H2 receptor Ki 2547.0 nM None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -15.17 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -6.7 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 39810.7 nM None
Homo sapiens HL-60 EC50 1.8 ug.mL-1 10.1021/jm970709p
Homo sapiens HL-60 IC20 20.0 ug ml-1 10.1021/jm970709p
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Absorption 95.0 % 10.1021/jm970530e
Homo sapiens Homo sapiens Activity 0.97 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens CL 11.8 mL.min-1.kg-1 10.1021/jm901893x
Homo sapiens Homo sapiens CL 13.3 mL.min-1.kg-1 10.1124/dmd.111.042309
Homo sapiens Homo sapiens CL 16.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 18.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 18.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.54 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 1.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 20.0 % 10.1021/jm901893x
Homo sapiens Homo sapiens F 84.0 % 10.1021/jm901846t
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fa 100.0 % 10.1021/jm991156g
Homo sapiens Homo sapiens Fabs 100.0 % 10.1124/dmd.110.034629
Homo sapiens Homo sapiens F_fraction 0.21 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.74 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.28 None 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 3.7 L.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 4.68 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens HT-29 Inhibition 95.0 % 10.1016/j.ejmech.2013.09.060
Homo sapiens Huh-7 Inhibition 1.0 % 10.1101/2020.04.13.039917
Homo sapiens Huh-7 Inhibition 10.0 % 10.1101/2020.04.13.039917
Homo sapiens HUVEC Activity nan None 10.1016/j.ejmech.2020.112555
Homo sapiens HUVEC Survival 82.07 % 10.1016/j.bmcl.2018.11.023
Homo sapiens Hydroxycarboxylic acid receptor 2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K562 Activity 1.4 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 6.0 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 7.2 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 10.0 % 10.1016/j.ejmech.2012.02.034
Homo sapiens K562 Activity 20.0 % 10.1021/jm8012745
Homo sapiens K562 Activity 85.4 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 95.0 % 10.1021/jm8012745
Homo sapiens K562 Activity 99.0 % 10.1021/acs.jmedchem.6b01787
Homo sapiens K562 Activity nan None 10.1016/j.bmc.2012.02.050
Homo sapiens K562 Activity nan None 10.1016/j.bmc.2012.11.019
Homo sapiens K562 Activity nan None 10.1016/j.bmcl.2008.04.082
Homo sapiens K562 Activity nan None 10.1016/j.ejmech.2012.02.034
Homo sapiens K562 Activity nan None 10.1021/acs.jmedchem.6b01075
Homo sapiens K562 Activity nan None 10.1021/jm8012745
Homo sapiens K562 Alpha max 0.7 None 10.1021/jm980440p
Homo sapiens K562 Dead cells 0.0 % 10.1021/jm980440p
Homo sapiens K562 GI 10.0 % 10.1016/j.bmc.2012.02.050
Homo sapiens K562 GI 10.0 % 10.1021/jm9016174
Homo sapiens K562 IC50 36700.0 nM 10.1021/acs.jmedchem.6b01879
Homo sapiens K562 IC50 37000.0 nM 10.1021/jm981064b
Homo sapiens K562 IC50 65280.0 nM 10.1016/j.bmc.2016.03.065
Homo sapiens K562 IC50 65280.0 nM 10.1016/j.bmc.2017.06.015
Homo sapiens K562 IC50 68270.0 nM 10.1016/j.bmc.2019.06.013
Homo sapiens K562 IC50 68920.0 nM 10.1016/j.ejmech.2022.114231
Homo sapiens K562 IC50 82200.0 nM 10.1016/j.bmc.2018.03.045
Homo sapiens K562 IC50 100000.0 nM 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Potency 1600.0 nM 10.1021/jm980440p
Homo sapiens K562 Ratio IC50 1.07 None 10.1007/s00044-008-9159-3
Homo sapiens K562 Ratio IC50 1.2 None 10.1016/j.bmc.2012.11.019
Homo sapiens K562 Ratio IC50 4.7 None 10.1016/j.bmc.2012.11.019
Homo sapiens K562 Survival 93.3 % 10.1021/jm501676v
Homo sapiens K562/A02 Activity 88.3 % 10.1021/acs.jmedchem.6b01787
Homo sapiens K562/A02 Activity 508.0 mm3 10.1021/acs.jmedchem.0c00337
Homo sapiens K562/A02 IC50 31280.0 nM 10.1021/acs.jmedchem.6b01879
Homo sapiens K562/A02 IC50 39860.0 nM 10.1016/j.ejmech.2022.114231
Homo sapiens K562/A02 IC50 56240.0 nM 10.1016/j.bmc.2017.06.015
Homo sapiens K562/A02 IC50 59240.0 nM 10.1016/j.bmc.2019.06.013
Homo sapiens K562/A02 IC50 67200.0 nM 10.1016/j.bmc.2018.03.045
Homo sapiens K562/A02 IC50 100000.0 nM 10.1021/acs.jmedchem.1c00246
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KB Activity nan None 10.1016/j.bmcl.2010.07.099
Homo sapiens KB Control 402.0 % 10.1021/jm00096a009
Homo sapiens KB Control 1124.0 % 10.1021/jm00096a009
Homo sapiens KB FC 1.06 None 10.1016/j.bmc.2010.07.055
Homo sapiens KB FC 1.29 None 10.1016/j.bmc.2010.07.055
Homo sapiens KB Fold reversion 14.0 None 10.1021/jm960361i
Homo sapiens KB Fold reversion 26.0 None 10.1021/jm00091a017
Homo sapiens KB IC50 25.0 ug.mL-1 10.1021/acs.jnatprod.5b00992
Homo sapiens KB IC50 19600.0 nM 10.1021/jm049949c
Homo sapiens KB IC50 nan None 10.1016/j.bmc.2010.02.046
Homo sapiens KB Increase 13.4 None 10.1021/jm00091a017
Homo sapiens KB Inhibition nan % 10.1016/j.bmc.2010.07.055
Homo sapiens KB Viability 75.0 % 10.1021/jm00091a017
Homo sapiens KB Viability 79.0 % 10.1021/jm960361i
Homo sapiens KB 3-1 Amax 2.2 pmoles 10.1021/jm049949c
Homo sapiens KB 3-1 EC50 14000.0 nM 10.1021/jm049949c
Homo sapiens KB 3-1 FC 1.18 None 10.1021/acs.jmedchem.1c01498
Homo sapiens KB 3-1 IC50 4.7 nM 10.1021/np0605889
Homo sapiens KB 3-1 IC50 3840.0 nM 10.1021/acs.jmedchem.1c01498
Homo sapiens KB 3-1 IC50 51700.0 nM 10.1021/jm049949c
Homo sapiens KB-C2 FC 267.57 None 10.1021/acs.jmedchem.1c01498
Homo sapiens KB-C2 IC50 7050.0 nM 10.1021/acs.jmedchem.1c01498
Homo sapiens KB/VJ300 IC50 100.0 nM 10.1021/acs.jnatprod.8b00170
Homo sapiens KB/VJ300 IC50 400.0 nM 10.1021/acs.jnatprod.9b00712
Homo sapiens KB/VJ300 IC50 800.0 nM 10.1021/acs.jnatprod.8b00919
Homo sapiens KB/VJ300 IC50 4600.0 nM 10.1021/acs.jnatprod.5b01117
Homo sapiens KB/VJ300 IC50 10000.0 nM 10.1021/acs.jnatprod.5b01117
Homo sapiens L02 Activity nan None 10.1016/j.ejmech.2022.114822
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver CL 0.0 mL.min-1.g-1 10.1021/acs.jnatprod.6b00944
Homo sapiens Liver CL 9.6 mL.min-1.g-1 10.1016/j.ejmech.2016.11.042
Homo sapiens Liver CL 9.6 mL.min-1.g-1 10.1016/j.ejmech.2017.02.044
Homo sapiens Liver CL 151.0 mL.min-1.g-1 10.1016/j.ejmech.2016.11.042
Homo sapiens Liver CL 151.0 mL.min-1.g-1 10.1016/j.ejmech.2017.02.044
Homo sapiens Liver CL 500.0 mL.min-1.kg-1 10.1021/acs.jmedchem.7b00746
Homo sapiens Liver CL 97000.0 mL.min-1.g-1 10.1021/acs.jnatprod.6b00944
Homo sapiens Liver Drug metabolism 0.06 nmol/min/mg 10.1016/j.bmc.2017.02.029
Homo sapiens Liver Stability 9.0 % 10.1016/j.bmc.2017.07.010
Homo sapiens Liver Stability 41.0 % 10.1021/acs.jmedchem.7b00497
Homo sapiens Liver Stability 78.0 % 10.1016/j.bmc.2017.02.029
Homo sapiens Liver T1/2 0.1167 hr 10.1021/acs.jnatprod.6b00944
Homo sapiens Liver T1/2 0.255 hr 10.1016/j.ejmech.2016.11.042
Homo sapiens Liver T1/2 0.255 hr 10.1016/j.ejmech.2017.02.044
Homo sapiens Liver T1/2 4.0 hr 10.1016/j.ejmech.2016.11.042
Homo sapiens Liver T1/2 4.0 hr 10.1016/j.ejmech.2017.02.044
Homo sapiens Liver T1/2 4.0 hr 10.1021/acs.jnatprod.6b00944
Homo sapiens Liver microsome CL 4.8e-05 mL.min-1.g-1 10.1124/dmd.111.039180
Homo sapiens Liver microsome CL 1.0 mL.min-1.g-1 10.1021/acs.jmedchem.6b00233
Homo sapiens Liver microsome CL 201.0 mL.min-1.g-1 10.1021/acs.jmedchem.6b00233
Homo sapiens Liver microsome CL 201.0 mL.min-1.g-1 10.1021/jm501124j
Homo sapiens Liver microsome CLH 130.0 uL/min 10.1016/j.bmcl.2016.06.001
Homo sapiens Liver microsome Drug metabolism 4.8 pmol/min 10.1124/dmd.111.039180
Homo sapiens Liver microsome Drug metabolism nan None 10.1016/j.bmc.2014.06.009
Homo sapiens Liver microsome PB 65.6 pmol 10.1124/dmd.111.039180
Homo sapiens Liver microsome Stability 13.0 % 10.1016/j.ejmech.2015.06.031
Homo sapiens Liver microsome Stability 94.0 % 10.1016/j.ejmech.2015.06.031
Homo sapiens Liver microsome Stability nan % 10.1016/j.bmc.2014.06.009
Homo sapiens Liver microsome T1/2 0.1783 hr 10.1016/j.bmcl.2016.06.001
Homo sapiens Liver microsome T1/2 0.1833 hr 10.1021/acs.jmedchem.6b00233
Homo sapiens Liver microsome T1/2 0.1917 hr 10.1021/jm501124j
Homo sapiens Liver microsome T1/2 0.3383 hr 10.1016/j.ejmech.2015.08.042
Homo sapiens Liver microsome T1/2 0.35 hr 10.1016/j.bmcl.2016.05.054
Homo sapiens Liver microsome T1/2 0.5333 hr 10.1016/j.ejmech.2016.01.057
Homo sapiens Liver microsome T1/2 1.0 hr 10.1021/acs.jmedchem.6b00233
Homo sapiens Liver microsome T1/2 3.0 hr 10.1016/j.ejmech.2015.08.042
Homo sapiens Liver microsomes CL 105.0 mL.min-1.g-1 10.1021/jm101073q
Homo sapiens Liver microsomes CLH 38.8 uL/min 10.1021/jm2015183
Homo sapiens Liver microsomes Stability 9.0 % 10.1021/jm101067y
Homo sapiens Liver microsomes Stability nan % 10.1021/jm901893x
Homo sapiens Liver microsomes T1/2 0.22 hr 10.1021/jm101073q
Homo sapiens LOX IMVI Activity nan None 10.1021/np010295+
Homo sapiens L-type amino acid transporter 3 Inhibition 82.7 % 10.1021/acs.jnatprod.6b00190
Homo sapiens LXR-alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens LXR-beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Macrophage cell line CC50 116600.0 nM 10.1016/j.ejmech.2017.09.014
Homo sapiens Macrophage cell line MTC 10.0 uM 10.1016/j.ejmech.2017.09.014
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 Activity nan None 10.1016/j.ejmech.2022.114822
Homo sapiens MCF7 Activity nan None 10.1021/acs.jnatprod.8b00362
Homo sapiens MCF7 EC50 1.0 ug.mL-1 10.1021/jm970709p
Homo sapiens MCF7 IC20 20.0 ug ml-1 10.1021/jm970709p
Homo sapiens MCF7 IC50 0.1 None 10.1021/jm0303204
Homo sapiens MCF7 IC50 0.3 None 10.1021/jm0303204
Homo sapiens MCF7 IC50 1.4 None 10.1021/jm0303204
Homo sapiens MCF7 IC50 14.0 None 10.1021/jm0303204
Homo sapiens MCF7 IC50 53.0 None 10.1021/jm0303204
Homo sapiens MCF7 IC50 1500.0 nM 10.1021/acs.jnatprod.8b00362
Homo sapiens MCF7 IC50 48910.0 nM 10.1016/j.ejmech.2018.01.027
Homo sapiens MCF7 IC50 51000.0 nM 10.1021/jm000282d
Homo sapiens MCF7 IC50 87830.0 nM 10.1016/j.ejmech.2022.114822
Homo sapiens MCF7 Inhibition 8.3 % 10.1016/j.ejmech.2021.113336
Homo sapiens MCF7 Survival 83.4 % 10.1016/j.ejmech.2018.01.027
Homo sapiens MCF7-VP IC50 0.2 None 10.1021/jm0303204
Homo sapiens MCF7-VP IC50 0.5 None 10.1021/jm0303204
Homo sapiens MCF7-VP IC50 1.6 None 10.1021/jm0303204
Homo sapiens MCF7-VP IC50 10.5 None 10.1021/jm0303204
Homo sapiens MCF7-VP IC50 12.0 None 10.1021/jm0303204
Homo sapiens MDA-MB-435 EC50 700.0 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 0.25 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 5.2 nM 10.1021/jm060593+
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens MES-SA Activity 1.63 None 10.1021/jm0491851
Homo sapiens MES-SA/Dx5 Activity nan None 10.1016/j.bmc.2022.116855
Homo sapiens MES-SA/Dx5 ED50 2.5 ug ml-1 10.1016/s0960-894x(00)00520-5
Homo sapiens MES-SA/Dx5 ED50 3.0 ug ml-1 10.1016/s0960-894x(00)00520-5
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance associated protein Activity 32.1 % None
Homo sapiens Multidrug resistance-associated protein 1 Activity 2.6 uM 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1016/j.cbi.2005.11.002
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1074/jbc.m703964200
Homo sapiens Multidrug resistance-associated protein 1 EC50 1925.0 nM 10.1021/acs.jmedchem.8b00834
Homo sapiens Multidrug resistance-associated protein 1 EC50 6800.0 nM 10.1016/j.ejmech.2019.03.054
Homo sapiens Multidrug resistance-associated protein 1 EC50 6800.0 nM 10.1016/j.ejmech.2019.111655
Homo sapiens Multidrug resistance-associated protein 1 EC50 27800.0 nM 10.1016/j.bmc.2014.09.023
Homo sapiens Multidrug resistance-associated protein 1 FC 1.5 None 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 1 FC 1.6 None 10.1021/acs.jmedchem.8b00834
Homo sapiens Multidrug resistance-associated protein 1 FC 5.4 None 10.1016/j.ejmech.2012.05.026
Homo sapiens Multidrug resistance-associated protein 1 IC50 3500.0 nM 10.1021/jm500697c
Homo sapiens Multidrug resistance-associated protein 1 IC50 4500.0 nM 10.1016/j.ejmech.2018.10.043
Homo sapiens Multidrug resistance-associated protein 1 IC50 6800.0 nM 10.1021/jm201305y
Homo sapiens Multidrug resistance-associated protein 1 IC50 9660.0 nM 10.1016/j.bmcl.2008.07.127
Homo sapiens Multidrug resistance-associated protein 1 Inhibition 50.0 % 10.1016/j.bmc.2010.07.031
Homo sapiens Multidrug resistance-associated protein 1 Inhibition 80.0 % 10.1016/j.bmc.2017.11.052
Homo sapiens Multidrug resistance-associated protein 1 Inhibition 100.0 % 10.1016/j.bmc.2017.11.052
Homo sapiens Multidrug resistance-associated protein 1 Ki 13200.0 nM 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 1 Ki 13400.0 nM 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 1 Ratio 1.9 None 10.1021/jm000282d
Homo sapiens Multidrug resistance-associated protein 1 Ratio nan None 10.1016/j.bmc.2010.06.004
Homo sapiens Multidrug resistance-associated protein 1 Ratio IC50 1.4 None 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 1 Ratio IC50 4.4 None 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 1 Ratio IC50 7.5 None 10.1021/jm900194w
Homo sapiens Multidrug resistance-associated protein 4 Activity 53.8 % None
Homo sapiens Multidrug resistance-associated protein 4 Activity 61.0 % 10.1016/s1357-2725(03)00236-x
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Multidrug resistance-associated protein 7 Activity 62.3 % 10.1124/mol.63.2.351
Homo sapiens Multidrug resistance protein 3 Activity nan None 10.1038/nrd3028
Homo sapiens Mu opioid receptor AC50 11596.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 9948.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens NCI/ADR-RES Activity 95.0 % 10.1021/jm060639z
Homo sapiens NCI/ADR-RES Activity nan None 10.1016/j.ejmech.2022.114822
Homo sapiens NCI/ADR-RES EC50 321.83 nM 10.1016/j.ejmech.2022.114822
Homo sapiens NCI/ADR-RES ED50 0.251 ug ml-1 10.1016/s0960-894x(00)00520-5
Homo sapiens NCI/ADR-RES ED50 2.5 ug ml-1 10.1016/s0960-894x(00)00520-5
Homo sapiens NCI/ADR-RES FC 39.62 None 10.1016/j.bmcl.2019.02.021
Homo sapiens NCI/ADR-RES IC50 0.6 None 10.1021/jm0303204
Homo sapiens NCI/ADR-RES IC50 3.7 None 10.1021/jm0303204
Homo sapiens NCI/ADR-RES IC50 6.3 None 10.1021/jm0303204
Homo sapiens NCI/ADR-RES IC50 19.0 None 10.1021/jm0303204
Homo sapiens NCI/ADR-RES IC50 210.0 None 10.1021/jm0303204
Homo sapiens NCI/ADR-RES IC50 2240.0 nM 10.1016/j.ejmech.2022.114822
Homo sapiens NCI/ADR-RES IC50 2250.0 nM 10.1016/j.bmcl.2019.02.021
Homo sapiens NCI/ADR-RES IC50 2830.0 nM 10.1016/j.ejmech.2022.114300
Homo sapiens NCI/ADR-RES IC50 78080.0 nM 10.1016/j.ejmech.2018.01.027
Homo sapiens NCI/ADR-RES IC50 100000.0 nM 10.1016/j.ejmech.2022.114822
Homo sapiens NCI/ADR-RES IC50 150000.0 nM 10.1021/acs.jmedchem.6b00605
Homo sapiens NCI/ADR-RES Inhibition 25.0 % 10.1016/j.ejmech.2021.113336
Homo sapiens NCI/ADR-RES Ratio IC50 21.0 None 10.1021/np100640f
Homo sapiens NCI/ADR-RES Ratio IC50 26.08 None 10.1016/j.ejmech.2022.114822
Homo sapiens NCI/ADR-RES Survival 90.18 % 10.1016/j.ejmech.2018.01.027
Homo sapiens NCI-H292 IC50 180.0 nM 10.1021/np500385b
Homo sapiens NCI-H292 IC50 1200.0 nM 10.1021/np500385b
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 29092.9 nM None
Homo sapiens Nuclear receptor subfamily 1 group I member 3 AC50 21000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens PBMC IC50 116600.0 nM 10.1021/acs.jmedchem.5b00428
Homo sapiens Peroxisome proliferator-activated receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens P-glycoprotein 1 Activity 0.7 None 10.1021/jm0614432
Homo sapiens P-glycoprotein 1 Activity 1.6 uM 10.1021/jm050542x
Homo sapiens P-glycoprotein 1 Activity 1.6 uM 10.1021/jm0614432
Homo sapiens P-glycoprotein 1 Activity 3.3 None 10.1016/j.bmc.2007.09.039
Homo sapiens P-glycoprotein 1 Activity 8.4 % 10.1021/acs.jmedchem.5b00058
Homo sapiens P-glycoprotein 1 Activity 8.6 None 10.1016/j.bmc.2009.08.020
Homo sapiens P-glycoprotein 1 Activity 15.46 % 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 Activity 18.1 % 10.1016/j.bmc.2017.07.003
Homo sapiens P-glycoprotein 1 Activity 21.0 nM/mg*min 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Activity 25.0 % 10.1016/s0006-2952(96)00656-9
Homo sapiens P-glycoprotein 1 Activity 25.03 % 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 Activity 26.0 % 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 Activity 28.0 % 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Activity 30.0 % 10.1016/j.bmc.2009.02.002
Homo sapiens P-glycoprotein 1 Activity 32.0 % 10.1016/j.bmc.2012.02.050
Homo sapiens P-glycoprotein 1 Activity 33.0 % 10.1016/j.bmc.2009.02.002
Homo sapiens P-glycoprotein 1 Activity 40.6 % 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 Activity 43.98 % 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 Activity 52.0 % 10.1016/j.bmc.2007.09.039
Homo sapiens P-glycoprotein 1 Activity 52.0 % 10.1016/j.bmc.2008.01.055
Homo sapiens P-glycoprotein 1 Activity 52.0 % 10.1016/s0928-0987(00)00097-x
Homo sapiens P-glycoprotein 1 Activity 58.54 % 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 Activity 60.3 % 10.1021/np500903a
Homo sapiens P-glycoprotein 1 Activity 62.0 % 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 Activity 65.7 % 10.1016/j.ejmech.2015.01.006
Homo sapiens P-glycoprotein 1 Activity 67.0 % 10.1016/j.bmc.2007.09.020
Homo sapiens P-glycoprotein 1 Activity 92.2 None 10.1021/acs.jmedchem.5b00058
Homo sapiens P-glycoprotein 1 Activity 137.4 None 10.1021/acs.jmedchem.5b00058
Homo sapiens P-glycoprotein 1 Activity 154.5 None 10.1016/j.bmc.2009.08.020
Homo sapiens P-glycoprotein 1 Activity 157.1 None 10.1021/acs.jmedchem.5b00058
Homo sapiens P-glycoprotein 1 Activity 188.0 % 10.1016/j.bmc.2007.10.006
Homo sapiens P-glycoprotein 1 Activity 198.8 None 10.1016/j.bmc.2016.08.022
Homo sapiens P-glycoprotein 1 Activity 251.1 None 10.1016/j.bmc.2009.08.020
Homo sapiens P-glycoprotein 1 Activity 319.0 % 10.1016/j.ejmech.2015.01.006
Homo sapiens P-glycoprotein 1 Activity 439.2 None 10.1016/j.bmc.2009.08.020
Homo sapiens P-glycoprotein 1 Activity 451.4 None 10.1016/j.bmc.2016.08.022
Homo sapiens P-glycoprotein 1 Activity 1078.0 None 10.1016/j.ejmech.2017.01.044
Homo sapiens P-glycoprotein 1 Activity 1190.0 % 10.1016/j.bmc.2007.09.020
Homo sapiens P-glycoprotein 1 Activity 2611.0 None 10.1016/j.ejmech.2017.01.044
Homo sapiens P-glycoprotein 1 Activity 641490.0 RLU 10.1021/acs.jmedchem.5b01203
Homo sapiens P-glycoprotein 1 Activity nan None 10.1002/jps.20101
Homo sapiens P-glycoprotein 1 Activity nan None 10.1006/abio.1998.3087
Homo sapiens P-glycoprotein 1 Activity nan None 10.1006/taap.2002.9461
Homo sapiens P-glycoprotein 1 Activity nan None 10.1007/s004240050829
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/0006-2952(93)90076-9
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bbrc.2004.01.156
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bcp.2003.08.027
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bmc.2007.10.006
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.ejmech.2014.02.051
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.ejmech.2018.10.033
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.ejmech.2021.113336
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.neuropharm.2006.07.038
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/s0006-2952(99)00262-2
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/s0378-5173(03)00372-7
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/acs.jmedchem.0c00337
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/acs.jmedchem.1c00246
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/acs.jmedchem.1c01452
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/jm701267q
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/np010295+
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/np100429s
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/np960178s
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1013358126640
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1025001131513
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/b:pham.0000026434.82855.69
Homo sapiens P-glycoprotein 1 Activity nan None 10.1038/nrd3028
Homo sapiens P-glycoprotein 1 Activity nan None 10.1038/sj.bjp.0706008
Homo sapiens P-glycoprotein 1 Activity nan None 10.1038/sj.leu.2400698
Homo sapiens P-glycoprotein 1 Activity nan None 10.1046/j.1365-2125.1999.00052.x
Homo sapiens P-glycoprotein 1 Activity nan None 10.1097/00002030-200006160-00034
Homo sapiens P-glycoprotein 1 Activity nan None 10.1124/jpet.102.044412
Homo sapiens P-glycoprotein 1 Activity nan None 10.1358/mf.2000.22.5.796646
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 Alpha max 0.7 % 10.1016/j.bmc.2012.11.019
Homo sapiens P-glycoprotein 1 Alpha max 0.7 None 10.1016/j.ejmech.2019.111655
Homo sapiens P-glycoprotein 1 Alpha max 0.7 None 10.1021/jm050542x
Homo sapiens P-glycoprotein 1 Binding site fraction 0.4 None 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 EC50 120.0 nM 10.1021/jm980121y
Homo sapiens P-glycoprotein 1 EC50 245.0 nM 10.1021/acs.jmedchem.5b00085
Homo sapiens P-glycoprotein 1 EC50 385.0 nM 10.1021/acs.jmedchem.5b00085
Homo sapiens P-glycoprotein 1 EC50 445.7 nM 10.1021/jm400930e
Homo sapiens P-glycoprotein 1 EC50 446.0 nM 10.1016/j.bmc.2015.07.027
Homo sapiens P-glycoprotein 1 EC50 446.0 nM 10.1021/acs.jmedchem.5b00085
Homo sapiens P-glycoprotein 1 EC50 500.0 nM 10.1016/j.ejmech.2019.03.054
Homo sapiens P-glycoprotein 1 EC50 500.0 nM 10.1016/j.ejmech.2019.111655
Homo sapiens P-glycoprotein 1 EC50 503.0 nM 10.1021/acs.jmedchem.5b00085
Homo sapiens P-glycoprotein 1 EC50 1041.0 nM 10.1016/j.bmc.2007.03.014
Homo sapiens P-glycoprotein 1 EC50 1253.0 nM 10.1016/j.bmc.2013.04.067
Homo sapiens P-glycoprotein 1 EC50 3100.0 nM 10.1021/jm010126m
Homo sapiens P-glycoprotein 1 EC50 4890.0 nM 10.1021/acs.jmedchem.5b00058
Homo sapiens P-glycoprotein 1 EC50 20000.0 nM 10.1016/j.bmc.2007.09.039
Homo sapiens P-glycoprotein 1 EC50 20000.0 nM 10.1016/j.bmcl.2008.05.055
Homo sapiens P-glycoprotein 1 EC50 20000.0 nM 10.1016/j.ejmech.2014.02.051
Homo sapiens P-glycoprotein 1 EC50 20000.0 nM 10.1021/jm060639z
Homo sapiens P-glycoprotein 1 EC50 20000.0 nM 10.1021/jm701267q
Homo sapiens P-glycoprotein 1 ED50 3.0 uM 10.1021/np970065o
Homo sapiens P-glycoprotein 1 FC 0.7 None 10.1021/acs.jmedchem.7b01340
Homo sapiens P-glycoprotein 1 FC 0.7 None 10.1021/jm9016174
Homo sapiens P-glycoprotein 1 FC 1.0 None 10.1016/j.bmc.2013.12.022
Homo sapiens P-glycoprotein 1 FC 1.0 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 FC 1.2 None 10.1021/jm300378k
Homo sapiens P-glycoprotein 1 FC 1.3 None 10.1016/j.ejmech.2021.113795
Homo sapiens P-glycoprotein 1 FC 1.38 None 10.1021/acs.jmedchem.6b01879
Homo sapiens P-glycoprotein 1 FC 1.5 None 10.1016/j.ejmech.2017.10.041
Homo sapiens P-glycoprotein 1 FC 1.6 None 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 FC 1.8 None 10.1016/j.ejmech.2021.113795
Homo sapiens P-glycoprotein 1 FC 1.8 None 10.1021/acs.jmedchem.1c01452
Homo sapiens P-glycoprotein 1 FC 1.8 None 10.1021/jm400930e
Homo sapiens P-glycoprotein 1 FC 1.9 None 10.1016/j.ejmech.2022.114822
Homo sapiens P-glycoprotein 1 FC 1.93 None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC 2.1 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 FC 2.3 None 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 FC 2.39 None 10.1016/j.ejmech.2016.03.070
Homo sapiens P-glycoprotein 1 FC 2.4 None 10.1016/j.bmc.2015.07.027
Homo sapiens P-glycoprotein 1 FC 2.4 None 10.1021/acs.jmedchem.5b00085
Homo sapiens P-glycoprotein 1 FC 2.46 None 10.1016/j.ejmech.2017.10.041
Homo sapiens P-glycoprotein 1 FC 2.48 None 10.1007/s00044-008-9159-3
Homo sapiens P-glycoprotein 1 FC 2.56 None 10.1021/acs.jmedchem.6b01879
Homo sapiens P-glycoprotein 1 FC 2.7 None 10.1016/j.bmc.2015.07.027
Homo sapiens P-glycoprotein 1 FC 2.8 None 10.1021/acs.jmedchem.5b01429
Homo sapiens P-glycoprotein 1 FC 3.11 None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC 3.2 None 10.1016/j.ejmech.2022.114822
Homo sapiens P-glycoprotein 1 FC 3.59 None 10.1016/j.ejmech.2017.10.041
Homo sapiens P-glycoprotein 1 FC 4.34 None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC 4.5 None 10.1021/jm400930e
Homo sapiens P-glycoprotein 1 FC 4.8 None 10.1021/acs.jmedchem.1c01452
Homo sapiens P-glycoprotein 1 FC 4.98 None 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 FC 5.3 None 10.1021/jm201121b
Homo sapiens P-glycoprotein 1 FC 5.36 None 10.1021/acs.jmedchem.6b01879
Homo sapiens P-glycoprotein 1 FC 5.6 None 10.1021/jm100035c
Homo sapiens P-glycoprotein 1 FC 6.0 None 10.1021/acs.jnatprod.9b01181
Homo sapiens P-glycoprotein 1 FC 6.2 None 10.1021/acs.jmedchem.5b01429
Homo sapiens P-glycoprotein 1 FC 6.2 None 10.1021/acs.jnatprod.9b01181
Homo sapiens P-glycoprotein 1 FC 6.46 None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC 8.34 None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC 8.5 None 10.1016/j.ejmech.2012.02.034
Homo sapiens P-glycoprotein 1 FC 8.5 None 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 FC 8.64 None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC 8.7 None 10.1021/acs.jmedchem.5b01429
Homo sapiens P-glycoprotein 1 FC 8.81 None 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 FC 10.78 None 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 FC 10.8 None 10.1021/acs.jmedchem.5b01429
Homo sapiens P-glycoprotein 1 FC 11.2 None 10.1021/acs.jmedchem.0c00337
Homo sapiens P-glycoprotein 1 FC 12.7 None 10.1021/jm400930e
Homo sapiens P-glycoprotein 1 FC 13.4 None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC 13.95 None 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 FC 13.97 None 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 FC 14.7 None 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 FC 17.9 None 10.1016/j.bmc.2012.05.075
Homo sapiens P-glycoprotein 1 FC 17.9 None 10.1021/jm3004398
Homo sapiens P-glycoprotein 1 FC 17.92 None 10.1021/acs.jmedchem.8b00335
Homo sapiens P-glycoprotein 1 FC 19.84 None 10.1021/acs.jmedchem.8b00335
Homo sapiens P-glycoprotein 1 FC 20.45 None 10.1016/j.ejmech.2017.10.041
Homo sapiens P-glycoprotein 1 FC 21.52 None 10.1021/acs.jmedchem.8b00335
Homo sapiens P-glycoprotein 1 FC 27.8 None 10.1021/acs.jmedchem.5b01429
Homo sapiens P-glycoprotein 1 FC 41.0 None 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 FC 48.08 None 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 FC 53.3 None 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 FC 64.82 None 10.1016/j.ejmech.2018.10.033
Homo sapiens P-glycoprotein 1 FC 129.9 None 10.1021/acs.jmedchem.5b01429
Homo sapiens P-glycoprotein 1 FC 267.57 None 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 FC nan None 10.1016/j.ejmech.2016.08.044
Homo sapiens P-glycoprotein 1 FC nan None 10.1021/acs.jmedchem.6b01879
Homo sapiens P-glycoprotein 1 FICI 0.5 None 10.1021/np200241c
Homo sapiens P-glycoprotein 1 FICI 1.0 None 10.1021/np200241c
Homo sapiens P-glycoprotein 1 Flu intensity 36.3 None 10.1016/j.bmc.2016.08.022
Homo sapiens P-glycoprotein 1 Flu intensity 69.3 None 10.1016/j.bmc.2008.08.071
Homo sapiens P-glycoprotein 1 Flu intensity 98.9 None 10.1021/np9001477
Homo sapiens P-glycoprotein 1 Flu intensity 101.3 None 10.1016/j.bmc.2016.08.022
Homo sapiens P-glycoprotein 1 Flu intensity 158.9 None 10.1021/np030036f
Homo sapiens P-glycoprotein 1 Flu intensity 170.0 None 10.1021/acs.jmedchem.5b00058
Homo sapiens P-glycoprotein 1 Flu intensity 212.5 None 10.1021/np060046r
Homo sapiens P-glycoprotein 1 Fluorescence intensity 11.2 None 10.1016/j.bmc.2006.09.028
Homo sapiens P-glycoprotein 1 GI 58.1 % 10.1007/s00044-012-0050-x
Homo sapiens P-glycoprotein 1 Hill coefficient 0.87 None 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 I0.5 1.6 uM 10.1016/j.ejmech.2019.111655
Homo sapiens P-glycoprotein 1 IC50 2.97 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 3.87 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 4.59 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 4.9 nM 10.1016/j.ejmech.2018.10.033
Homo sapiens P-glycoprotein 1 IC50 5.29 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 6.7 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 7.05 nM 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 IC50 8.51 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 8.6 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 8.9 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 10.17 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 10.37 nM 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 IC50 16.49 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 18.43 nM 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 IC50 23.08 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 28.16 nM 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 IC50 29.0 nM 10.1016/j.ejmech.2014.09.084
Homo sapiens P-glycoprotein 1 IC50 35.02 nM 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 IC50 36.77 nM 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 IC50 38.0 nM 10.1016/j.ejmech.2021.113795
Homo sapiens P-glycoprotein 1 IC50 38.0 nM 10.1021/acs.jmedchem.5b00085
Homo sapiens P-glycoprotein 1 IC50 76.4 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 76.9 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 85.7 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 195.0 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 300.0 nM 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 IC50 400.0 nM 10.1016/j.bbrc.2004.06.020
Homo sapiens P-glycoprotein 1 IC50 400.0 nM 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 IC50 412.0 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 456.0 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 500.0 nM 10.1021/jm201305y
Homo sapiens P-glycoprotein 1 IC50 522.0 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 575.44 nM 10.1021/jm201705f
Homo sapiens P-glycoprotein 1 IC50 630.0 nM 10.1021/acs.jmedchem.1c01989
Homo sapiens P-glycoprotein 1 IC50 708.0 nM 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 IC50 710.0 nM 10.1021/acs.jnatprod.1c00821
Homo sapiens P-glycoprotein 1 IC50 740.0 nM 10.1016/j.ejmech.2014.09.084
Homo sapiens P-glycoprotein 1 IC50 810.0 nM 10.1021/acs.jnatprod.9b01181
Homo sapiens P-glycoprotein 1 IC50 1200.0 nM 10.1021/acs.jmedchem.9b00779
Homo sapiens P-glycoprotein 1 IC50 1300.0 nM 10.1016/j.ejmech.2018.10.043
Homo sapiens P-glycoprotein 1 IC50 1300.0 nM 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 IC50 1480.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 IC50 1600.0 nM 10.1016/j.bmc.2012.11.019
Homo sapiens P-glycoprotein 1 IC50 1700.0 nM 10.1039/C2MD20286G
Homo sapiens P-glycoprotein 1 IC50 2100.0 nM None
Homo sapiens P-glycoprotein 1 IC50 2110.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 IC50 2210.0 nM 10.1097/00001813-200302000-00012
Homo sapiens P-glycoprotein 1 IC50 2980.0 nM 10.1021/acs.jmedchem.0c00337
Homo sapiens P-glycoprotein 1 IC50 3100.0 nM 10.1016/s0960-894x(99)00243-7
Homo sapiens P-glycoprotein 1 IC50 3700.0 nM 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 IC50 4200.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 4200.0 nM None
Homo sapiens P-glycoprotein 1 IC50 4570.88 nM 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 IC50 4570.88 nM 10.1016/j.bmc.2007.11.057
Homo sapiens P-glycoprotein 1 IC50 4570.88 nM 10.1016/j.bmc.2008.07.034
Homo sapiens P-glycoprotein 1 IC50 4700.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 4700.0 nM 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 IC50 4700.0 nM 10.1021/acs.jnatprod.8b00507
Homo sapiens P-glycoprotein 1 IC50 4780.0 nM 10.1097/00001813-200302000-00012
Homo sapiens P-glycoprotein 1 IC50 5200.0 nM 10.1016/j.bmc.2009.01.072
Homo sapiens P-glycoprotein 1 IC50 5420.0 nM 10.1016/j.bmcl.2008.07.127
Homo sapiens P-glycoprotein 1 IC50 5754.4 nM 10.1016/j.bmc.2007.11.057
Homo sapiens P-glycoprotein 1 IC50 5800.0 nM 10.1016/j.bmc.2007.11.057
Homo sapiens P-glycoprotein 1 IC50 6150.0 nM 10.1016/j.ejmech.2018.10.033
Homo sapiens P-glycoprotein 1 IC50 6300.0 nM 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 IC50 6470.0 nM 10.1021/acs.jmedchem.1c00246
Homo sapiens P-glycoprotein 1 IC50 6500.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 6606.93 nM 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 IC50 6606.93 nM 10.1016/j.bmc.2007.11.057
Homo sapiens P-glycoprotein 1 IC50 8440.0 nM 10.1023/b:pham.0000036913.90332.b1
Homo sapiens P-glycoprotein 1 IC50 9800.0 nM 10.1016/j.bmc.2010.12.043
Homo sapiens P-glycoprotein 1 IC50 10100.0 nM 10.1016/j.ejmech.2019.05.053
Homo sapiens P-glycoprotein 1 IC50 10370.0 nM 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 IC50 10730.0 nM 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 IC50 11900.0 nM 10.1016/j.ejmech.2021.113336
Homo sapiens P-glycoprotein 1 IC50 12000.0 nM 10.1039/C2MD20286G
Homo sapiens P-glycoprotein 1 IC50 14000.0 nM 10.1021/jm900253g
Homo sapiens P-glycoprotein 1 IC50 17250.0 nM 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 IC50 17550.0 nM 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 IC50 17800.0 nM 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 IC50 18000.0 nM 10.1021/jm301084z
Homo sapiens P-glycoprotein 1 IC50 18900.0 nM 10.1124/jpet.102.046532
Homo sapiens P-glycoprotein 1 IC50 20200.0 nM 10.1021/acs.jmedchem.1c01452
Homo sapiens P-glycoprotein 1 IC50 28900.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 30000.0 nM 10.1021/acs.jnatprod.1c00821
Homo sapiens P-glycoprotein 1 IC50 31280.0 nM 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 IC50 38200.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 42000.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 53000.0 nM 10.1016/s0960-894x(99)00243-7
Homo sapiens P-glycoprotein 1 IC50 65600.0 nM 10.1016/j.bmcl.2016.09.076
Homo sapiens P-glycoprotein 1 IC50 168200.0 nM 10.1021/acs.jmedchem.1c01452
Homo sapiens P-glycoprotein 1 IC50 224000.0 nM None
Homo sapiens P-glycoprotein 1 IC50 303530.0 nM 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 IC50 446500.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 nan None 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 IC50 nan None 10.1021/jm058046w
Homo sapiens P-glycoprotein 1 INH 1.6 uM 10.1021/jm9016174
Homo sapiens P-glycoprotein 1 Inhibition 20.0 % 10.1016/j.ejmech.2019.03.054
Homo sapiens P-glycoprotein 1 Inhibition 20.0 % 10.1016/j.ejmech.2019.111655
Homo sapiens P-glycoprotein 1 Inhibition 26.1 % 10.1021/acs.jmedchem.0c00337
Homo sapiens P-glycoprotein 1 Inhibition 28.0 % 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Inhibition 35.0 % 10.1016/j.bmc.2008.09.065
Homo sapiens P-glycoprotein 1 Inhibition 60.0 % 10.1016/0006-2952(94)90580-0
Homo sapiens P-glycoprotein 1 Inhibition 61.0 % 10.1016/j.ejmech.2017.02.022
Homo sapiens P-glycoprotein 1 Inhibition 63.0 % 10.1016/j.bmc.2008.09.065
Homo sapiens P-glycoprotein 1 Inhibition 70.0 % 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 Inhibition 82.8 % 10.1016/j.ejmech.2021.113676
Homo sapiens P-glycoprotein 1 Inhibition 84.0 % 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 Inhibition 89.0 % 10.1021/np050283e
Homo sapiens P-glycoprotein 1 Inhibition 95.0 % 10.1021/np050283e
Homo sapiens P-glycoprotein 1 Inhibition 98.67 % 10.1016/j.bmcl.2008.04.082
Homo sapiens P-glycoprotein 1 Inhibition 129.0 % 10.1021/np050283e
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1007/s00044-012-0203-y
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1007/s00044-013-0805-z
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmc.2010.02.062
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmc.2012.02.050
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmc.2013.04.067
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmcl.2011.12.065
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2011.07.048
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2012.02.034
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2015.01.006
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2017.10.041
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2018.10.033
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2019.111584
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2019.111726
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2021.113930
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/acs.jmedchem.0c01741
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/acs.jmedchem.1c01498
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/acs.jmedchem.5b01203
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/acs.jmedchem.6b01879
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/acs.jmedchem.8b00335
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/acsmedchemlett.8b00324
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/jm201121b
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/jm5005623
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/np100429s
Homo sapiens P-glycoprotein 1 Inhibition nan % None
Homo sapiens P-glycoprotein 1 Inhibitory ratio 7.27 None 10.1021/jm021090g
Homo sapiens P-glycoprotein 1 K 0.0092 /s 10.1016/j.bmc.2017.06.015
Homo sapiens P-glycoprotein 1 Ki 300.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 Ki 880.0 nM 10.1023/a:1022359300826
Homo sapiens P-glycoprotein 1 Ki 1750.0 nM 10.1021/jm201121b
Homo sapiens P-glycoprotein 1 Ki 2500.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 Ki 3000.0 nM 10.1023/a:1011076217118
Homo sapiens P-glycoprotein 1 Ki 15100.0 nM 10.1023/a:1016140429238
Homo sapiens P-glycoprotein 1 Km 2000.0 nM 10.1016/j.bmcl.2005.03.038
Homo sapiens P-glycoprotein 1 Km 2000.0 nM 10.1074/jbc.271.6.3163
Homo sapiens P-glycoprotein 1 Km 4060.0 nM 10.1023/a:1013358126640
Homo sapiens P-glycoprotein 1 Km 24000.0 nM 10.1016/j.bmc.2012.05.075
Homo sapiens P-glycoprotein 1 Km 24000.0 nM 10.1021/jm3004398
Homo sapiens P-glycoprotein 1 Km 24000.0 nM 10.1021/jm900253g
Homo sapiens P-glycoprotein 1 % maximum response 56.4 % None
Homo sapiens P-glycoprotein 1 MIC 8000.0 nM 10.1021/jm201121b
Homo sapiens P-glycoprotein 1 Papp 0.73 10^-6 cm/s 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 Papp 2.94 10^-6 cm/s 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 Papp 4.55 10^-6 cm/s 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 Papp 6.04 10^-6 cm/s 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 Papp 8.02 10^-6 cm/s 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 Papp 591.0 nm/s None
Homo sapiens P-glycoprotein 1 Papp 687.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio 0.7 None 10.1021/jm058046w
Homo sapiens P-glycoprotein 1 Ratio 0.89 None 10.1016/j.bmc.2011.09.005
Homo sapiens P-glycoprotein 1 Ratio 0.9 None 10.1021/np200241c
Homo sapiens P-glycoprotein 1 Ratio 1.07 None 10.1021/acsmedchemlett.8b00324
Homo sapiens P-glycoprotein 1 Ratio 1.16 None 10.1021/acsmedchemlett.8b00324
Homo sapiens P-glycoprotein 1 Ratio 1.2 None 10.1021/acsmedchemlett.8b00324
Homo sapiens P-glycoprotein 1 Ratio 1.26 None 10.1021/acsmedchemlett.8b00324
Homo sapiens P-glycoprotein 1 Ratio 1.35 None 10.1021/acsmedchemlett.8b00324
Homo sapiens P-glycoprotein 1 Ratio 1.4 None 10.1016/j.bmcl.2016.11.010
Homo sapiens P-glycoprotein 1 Ratio 1.46 None 10.1016/j.bmc.2015.05.016
Homo sapiens P-glycoprotein 1 Ratio 1.8 None 10.1021/np200241c
Homo sapiens P-glycoprotein 1 Ratio 2.76 None 10.1016/j.ejmech.2020.112985
Homo sapiens P-glycoprotein 1 Ratio 2.85 None 10.1016/j.bmcl.2017.01.033
Homo sapiens P-glycoprotein 1 Ratio 2.9 None 10.1016/j.ejmech.2015.01.004
Homo sapiens P-glycoprotein 1 Ratio 2.94 None 10.1016/j.bmc.2011.09.005
Homo sapiens P-glycoprotein 1 Ratio 3.0 None 10.1021/acs.jnatprod.5b00132
Homo sapiens P-glycoprotein 1 Ratio 3.602 None 10.1021/acs.jmedchem.0c02011
Homo sapiens P-glycoprotein 1 Ratio 3.8 None 10.1021/acs.jmedchem.5b00085
Homo sapiens P-glycoprotein 1 Ratio 3.84 None 10.1016/j.bmcl.2008.05.034
Homo sapiens P-glycoprotein 1 Ratio 4.0 None 10.1021/np3004003
Homo sapiens P-glycoprotein 1 Ratio 4.1 None 10.1021/acs.jnatprod.8b00326
Homo sapiens P-glycoprotein 1 Ratio 4.16 None 10.1016/j.bmcl.2012.03.005
Homo sapiens P-glycoprotein 1 Ratio 4.2 None 10.1016/j.bmcl.2008.05.034
Homo sapiens P-glycoprotein 1 Ratio 4.35 None 10.1016/j.ejmech.2010.02.024
Homo sapiens P-glycoprotein 1 Ratio 4.98 None 10.1016/j.bmc.2015.05.016
Homo sapiens P-glycoprotein 1 Ratio 5.29 None 10.1016/j.bmcl.2020.127522
Homo sapiens P-glycoprotein 1 Ratio 5.61 None 10.1016/j.bmcl.2008.05.034
Homo sapiens P-glycoprotein 1 Ratio 5.66 None 10.1016/j.ejmech.2015.01.004
Homo sapiens P-glycoprotein 1 Ratio 5.9 None 10.1021/jm000282d
Homo sapiens P-glycoprotein 1 Ratio 6.46 None 10.1039/C6MD00431H
Homo sapiens P-glycoprotein 1 Ratio 6.6 None 10.1016/j.ejmech.2017.01.044
Homo sapiens P-glycoprotein 1 Ratio 6.6 None 10.1016/j.ejmech.2020.112985
Homo sapiens P-glycoprotein 1 Ratio 6.6 None 10.1021/acs.jnatprod.9b00019
Homo sapiens P-glycoprotein 1 Ratio 6.6 None 10.1021/np3004003
Homo sapiens P-glycoprotein 1 Ratio 7.1 None 10.1016/j.bmc.2016.08.022
Homo sapiens P-glycoprotein 1 Ratio 7.3 None 10.1021/jm058046w
Homo sapiens P-glycoprotein 1 Ratio 7.86 None 10.1016/j.bmc.2009.04.021
Homo sapiens P-glycoprotein 1 Ratio 8.6 None 10.1016/j.bmc.2016.08.022
Homo sapiens P-glycoprotein 1 Ratio 8.6 None 10.1021/jm300424n
Homo sapiens P-glycoprotein 1 Ratio 8.71 None 10.1016/j.ejmech.2012.02.042
Homo sapiens P-glycoprotein 1 Ratio 8.95 None 10.1021/acs.jnatprod.5b00370
Homo sapiens P-glycoprotein 1 Ratio 9.25 None 10.1021/np9001477
Homo sapiens P-glycoprotein 1 Ratio 9.66 None 10.1021/acs.jnatprod.8b00326
Homo sapiens P-glycoprotein 1 Ratio 9.7 None 10.1021/np060046r
Homo sapiens P-glycoprotein 1 Ratio 12.5 None 10.1016/j.ejmech.2017.04.025
Homo sapiens P-glycoprotein 1 Ratio 12.5 None 10.1021/acs.jnatprod.6b01084
Homo sapiens P-glycoprotein 1 Ratio 13.14 None 10.1021/np030036f
Homo sapiens P-glycoprotein 1 Ratio 13.64 None 10.1021/acs.jmedchem.1c00246
Homo sapiens P-glycoprotein 1 Ratio 13.7 None 10.1016/j.bmc.2008.08.071
Homo sapiens P-glycoprotein 1 Ratio 17.1 None 10.1016/s0960-894x(99)00243-7
Homo sapiens P-glycoprotein 1 Ratio 17.5 None 10.1016/j.bmc.2014.09.041
Homo sapiens P-glycoprotein 1 Ratio 17.59 None 10.1016/j.bmc.2016.04.055
Homo sapiens P-glycoprotein 1 Ratio 17.72 None 10.1021/acs.jnatprod.5b00370
Homo sapiens P-glycoprotein 1 Ratio 17.9 None 10.1021/jm900253g
Homo sapiens P-glycoprotein 1 Ratio 20.0 None 10.1021/jm301441w
Homo sapiens P-glycoprotein 1 Ratio 23.2 None 10.1021/np200202h
Homo sapiens P-glycoprotein 1 Ratio 27.4 None 10.1016/j.bmcl.2016.04.064
Homo sapiens P-glycoprotein 1 Ratio 30.0 None 10.1016/j.bmcl.2005.03.038
Homo sapiens P-glycoprotein 1 Ratio 42.56 None 10.1021/jm060056p
Homo sapiens P-glycoprotein 1 Ratio 230482.0 None 10.1016/j.ejmech.2019.03.054
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 7.64 None None
Homo sapiens P-glycoprotein 1 Ratio IC50 0.5 None 10.1021/np900091y
Homo sapiens P-glycoprotein 1 Ratio IC50 0.89 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 0.91 None 10.1016/j.bmc.2018.10.027
Homo sapiens P-glycoprotein 1 Ratio IC50 0.98 None 10.1016/j.bmc.2018.10.027
Homo sapiens P-glycoprotein 1 Ratio IC50 1.0 None 10.1016/j.bmcl.2009.07.127
Homo sapiens P-glycoprotein 1 Ratio IC50 1.04 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 1.17 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 1.2 None 10.1021/acs.jmedchem.2c01175
Homo sapiens P-glycoprotein 1 Ratio IC50 1.3 None 10.1021/jm9016174
Homo sapiens P-glycoprotein 1 Ratio IC50 1.37 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 1.8 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 1.93 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 2.5 None 10.1021/jm800403b
Homo sapiens P-glycoprotein 1 Ratio IC50 2.7 None 10.1016/j.ejmech.2014.09.084
Homo sapiens P-glycoprotein 1 Ratio IC50 2.8 None 10.1021/np500903a
Homo sapiens P-glycoprotein 1 Ratio IC50 2.82 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 2.97 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 3.0 None 10.1021/acs.jmedchem.2c01175
Homo sapiens P-glycoprotein 1 Ratio IC50 3.0 None 10.1021/acs.jmedchem.6b00605
Homo sapiens P-glycoprotein 1 Ratio IC50 3.04 None 10.1016/j.ejmech.2011.07.048
Homo sapiens P-glycoprotein 1 Ratio IC50 3.9 None 10.1021/jm9016174
Homo sapiens P-glycoprotein 1 Ratio IC50 4.1 None 10.1016/j.bmc.2018.10.027
Homo sapiens P-glycoprotein 1 Ratio IC50 4.32 None 10.1016/j.bmc.2018.10.027
Homo sapiens P-glycoprotein 1 Ratio IC50 4.34 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 4.5 None 10.1016/j.ejmech.2014.06.016
Homo sapiens P-glycoprotein 1 Ratio IC50 4.75 None 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 Ratio IC50 5.07 None 10.1016/j.ejmech.2019.05.053
Homo sapiens P-glycoprotein 1 Ratio IC50 5.4 None 10.1021/np900091y
Homo sapiens P-glycoprotein 1 Ratio IC50 5.66 None 10.1016/j.ejmech.2022.114231
Homo sapiens P-glycoprotein 1 Ratio IC50 6.0 None 10.1021/acs.jmedchem.1c01989
Homo sapiens P-glycoprotein 1 Ratio IC50 6.0 None 10.1021/acs.jmedchem.6b00605
Homo sapiens P-glycoprotein 1 Ratio IC50 6.2 None 10.1021/np500903a
Homo sapiens P-glycoprotein 1 Ratio IC50 6.23 None 10.1016/j.ejmech.2011.07.048
Homo sapiens P-glycoprotein 1 Ratio IC50 7.0 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 8.7 None 10.1021/np500903a
Homo sapiens P-glycoprotein 1 Ratio IC50 8.79 None 10.1016/j.ejmech.2011.07.048
Homo sapiens P-glycoprotein 1 Ratio IC50 10.64 None 10.1016/j.ejmech.2011.07.048
Homo sapiens P-glycoprotein 1 Ratio IC50 10.8 None 10.1021/np500903a
Homo sapiens P-glycoprotein 1 Ratio IC50 11.0 None 10.1021/acs.jmedchem.6b00605
Homo sapiens P-glycoprotein 1 Ratio IC50 13.7 None 10.1021/acs.jnatprod.8b00507
Homo sapiens P-glycoprotein 1 Ratio IC50 14.7 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 15.69 None 10.1016/j.bmc.2018.10.027
Homo sapiens P-glycoprotein 1 Ratio IC50 18.0 None 10.1021/acs.jmedchem.6b00605
Homo sapiens P-glycoprotein 1 Ratio IC50 19.12 None 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 Ratio IC50 20.0 None 10.1021/np200241c
Homo sapiens P-glycoprotein 1 Ratio IC50 20.85 None 10.1016/j.ejmech.2011.07.048
Homo sapiens P-glycoprotein 1 Ratio IC50 22.0 None 10.1021/np200241c
Homo sapiens P-glycoprotein 1 Ratio IC50 22.9 None 10.1016/j.ejmech.2020.112422
Homo sapiens P-glycoprotein 1 Ratio IC50 23.99 None 10.1016/j.bmc.2017.08.003
Homo sapiens P-glycoprotein 1 Ratio IC50 27.8 None 10.1021/np500903a
Homo sapiens P-glycoprotein 1 Ratio IC50 29.0 None 10.1016/j.bmcl.2009.07.127
Homo sapiens P-glycoprotein 1 Ratio IC50 31.7 None 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 Ratio IC50 46.0 None 10.1021/np200241c
Homo sapiens P-glycoprotein 1 Ratio IC50 76.81 None 10.1016/j.ejmech.2011.07.048
Homo sapiens P-glycoprotein 1 Ratio IC50 129.9 None 10.1021/np500903a
Homo sapiens P-glycoprotein 1 Ratio IC50 156.74 None 10.1016/j.bmc.2018.10.027
Homo sapiens P-glycoprotein 1 Ratio_Papp 1.16 None None
Homo sapiens P-glycoprotein 1 RFU 0.89 None 10.1016/j.bmc.2012.10.041
Homo sapiens P-glycoprotein 1 RFU 2.94 None 10.1016/j.bmc.2012.10.041
Homo sapiens P-glycoprotein 1 RFU 35900.0 None 10.1016/j.bmc.2013.04.067
Homo sapiens P-glycoprotein 1 RFU 46100.0 None 10.1016/j.bmc.2013.04.067
Homo sapiens P-glycoprotein 1 RFU 53000.0 None 10.1016/j.bmc.2013.04.067
Homo sapiens P-glycoprotein 1 RFU 98700.0 None 10.1016/j.bmc.2013.04.067
Homo sapiens P-glycoprotein 1 RLU 4.26 None 10.1007/s00044-011-9925-5
Homo sapiens P-glycoprotein 1 Survival 23.0 % 10.1016/j.ejmech.2018.10.033
Homo sapiens P-glycoprotein 1 Survival 23.05 % 10.1016/j.ejmech.2019.111668
Homo sapiens P-glycoprotein 1 Survival 43.0 % 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 Survival nan None 10.1016/j.ejmech.2018.10.038
Homo sapiens P-glycoprotein 1 Vmax 65.0 uM 10.1016/j.bmcl.2005.03.038
Homo sapiens Phosphodiesterase 3A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 13462.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 7400.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma K(p,uu,CSF) 1.13 None 10.1021/jm901036q
Homo sapiens Plasma PPB 87.6 % 10.1016/j.ejmech.2015.07.034
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prion protein RUmax nan None 10.1016/j.ejmech.2011.04.016
Homo sapiens Progesterone receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 9466.2 nM None
Homo sapiens Retinoic acid receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Retinoic acid receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Retinoic acid receptor gamma AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens S1B1-20 IC50 17270.0 nM 10.1021/jm9804477
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 473.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 5087.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 340.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 442.0 nM None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 126.0 nM None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 50.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 1200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 165.0 nM None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 105.0 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 1300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 297.0 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 155.0 nM None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 680.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 745.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 240.0 nM None
Homo sapiens Serotonin transporter Ki 127.0 nM None
Homo sapiens Serum albumin Kd 645654.23 nM 10.1021/jm7012826
Homo sapiens Serum albumin Log B/F 0.278 None 10.1021/jm00179a017
Homo sapiens Serum albumin Log K' 0.52 None 10.1021/jm010960b
Homo sapiens SH-SY5Y Potency 28183.8 nM None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Skin log Pe -0.36 None 10.1016/j.bmcl.2009.11.039
Homo sapiens SK-N-MC Activity nan None 10.1038/nchembio.79
Homo sapiens SK-N-SH Activity nan None 10.1038/nchembio.79
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) IC50 3300.0 nM 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 74.4 % 10.1021/jm00381a019
Homo sapiens Sodium channel protein type V alpha subunit AC50 16522.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Sodium channel protein type V alpha subunit IC50 41500.0 nM 10.1093/cvr/cvr044
Homo sapiens Solute carrier family 22 member 1 Activity nan None 10.1124/mol.51.6.913
Homo sapiens Solute carrier family 22 member 1 IC50 6800.0 nM 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Inhibition 86.4 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Ki 2900.0 nM None
Homo sapiens Solute carrier family 22 member 4 Activity 8.8 % None
Homo sapiens Solute carrier family 22 member 4 Activity nan None None
Homo sapiens Solute carrier family 22 member 5 Activity 2.4 % None
Homo sapiens Solute carrier family 22 member 5 Activity nan None None
Homo sapiens Solute carrier organic anion transporter family member 1A2 Inhibition 100.0 % None
Homo sapiens Solute carrier organic anion transporter family member 1B1 IC50 32000.0 nM 10.1124/dmd.111.042382
Homo sapiens Solute carrier organic anion transporter family member 1B1 IC50 64000.0 nM 10.1124/dmd.111.042382
Homo sapiens Solute carrier organic anion transporter family member 1B1 IC50 600000.0 nM 10.1124/dmd.111.042382
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 40.3 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Ki 52000.0 nM 10.1124/dmd.111.042382
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition -9.0 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -62.6 % 10.1021/jm300212s
Homo sapiens SW-620 FC 1.08 None 10.1021/acs.jmedchem.1c01498
Homo sapiens SW-620 FC 14.1 None 10.1021/acs.jmedchem.1c01498
Homo sapiens SW-620 IC50 300.0 nM 10.1021/acs.jmedchem.1c01498
Homo sapiens SW-620 IC50 7110.0 nM 10.1021/acs.jmedchem.1c01498
Homo sapiens SW-620 Ratio IC50 1.1 None 10.1016/j.bmc.2018.10.027
Homo sapiens SW-620 Ratio IC50 1.18 None 10.1016/j.bmc.2018.10.027
Homo sapiens SW-620 Ratio IC50 1.29 None 10.1016/j.bmc.2018.10.027
Homo sapiens SW620/AD300 IC50 30000.0 nM 10.1021/acs.jnatprod.9b01181
Homo sapiens SW620/AD300 Ratio IC50 0.1 None 10.1021/acs.jmedchem.1c01989
Homo sapiens T-24 IC50 0.5 None 10.1021/jm0303204
Homo sapiens T-24 IC50 1.3 None 10.1021/jm0303204
Homo sapiens T-24 IC50 3.0 None 10.1021/jm0303204
Homo sapiens T-24 IC50 7.0 None 10.1021/jm0303204
Homo sapiens T-24 IC50 48.0 None 10.1021/jm0303204
Homo sapiens THP-1 Activity 25.0 % 10.1128/aac.00090-07
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 13286.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 20542.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 22387.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 26608.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 33498.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 35481.3 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel IC50 200.0 nM 10.1038/srep02100
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit AC50 4164.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 150.0 nM 10.1021/jm00056a003
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 23500.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 24000.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 47000.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 50000.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated potassium channel subunit Kv1.3 IC50 8000.0 nM 10.1016/j.bmcl.2012.09.080
Homo sapiens Voltage-gated potassium channel subunit Kv1.5 Inhibition nan % None
Homo sapiens Whole blood Retention_time 5.95 min 10.1007/s00044-012-9977-1
Leishmania amazonensis Leishmania amazonensis IC50 19100.0 nM 10.1128/aac.00404-07
Leishmania amazonensis Leishmania amazonensis IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania donovani Leishmania donovani Activity nan None 10.1128/aac.00522-07
Leishmania donovani Leishmania donovani IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania infantum Leishmania infantum IC50 43200.0 nM 10.1128/aac.00404-07
Leishmania infantum Leishmania infantum IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania major Leishmania major IC50 40300.0 nM 10.1128/aac.00404-07
Leishmania major Leishmania major IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania mexicana Leishmania mexicana IC50 nan None 10.1016/j.bmc.2010.01.068
Mesocricetus auratus BHK-21 Activity nan None 10.1074/jbc.m703964200
Mesocricetus auratus BHK-21 IC50 10600.0 nM 10.1016/j.bmc.2010.07.031
Mesocricetus auratus BHK-21 IC50 100000.0 nM 10.1016/j.bmc.2010.07.031
Mus musculus EMT6 IC50 5800.0 nM 10.1016/s0960-894x(99)00030-x
Mus musculus L5178Y Activity 7.4 None 10.1016/j.bmc.2009.08.020
Mus musculus L5178Y Activity 97.1 None 10.1016/j.bmc.2009.08.020
Mus musculus L5178Y EC50 nan nM 10.1021/jm980121y
Mus musculus L5178Y IC50 47.85 nM 10.1016/j.bmcl.2020.127522
Mus musculus L5178Y IC50 100.0 nM 10.1016/j.bmcl.2020.127522
Mus musculus L5178Y IC50 47850.0 nM 10.1016/j.bmcl.2016.04.064
Mus musculus L5178Y IC50 100000.0 nM 10.1016/j.bmcl.2016.04.064
Mus musculus L5178Y ID50 42.0 ug ml-1 10.1016/j.bmcl.2008.05.034
Mus musculus L5178Y Ratio 25.9 None 10.1021/acs.jmedchem.6b00276
Mus musculus L929 IC50 88000.0 nM 10.1021/acs.jmedchem.8b00834
Mus musculus L929 IC50 89000.0 nM 10.1016/j.bmc.2015.07.027
Mus musculus L929 IC50 89200.0 nM 10.1016/j.ejmech.2021.113795
Mus musculus L929 IC50 89200.0 nM 10.1021/acs.jmedchem.5b00085
Mus musculus L929 IC50 89200.0 nM 10.1021/jm201121b
Mus musculus L929 IC50 89200.0 nM 10.1021/jm400930e
Mus musculus Liver Stability 23.1 % 10.1021/acs.jmedchem.6b00015
Mus musculus Liver Stability 30.0 % 10.1021/acs.jmedchem.7b00497
Mus musculus Mus musculus Concentration 1.0 % 10.1021/jm00119a026
Mus musculus Mus musculus IC50 89000.0 nM 10.1016/j.ejmech.2016.09.070
Mus musculus Mus musculus ID50 30.0 mg.kg-1 10.1021/jm00400a006
Mus musculus Mus musculus RF 100.0 None 10.1021/jm000244u
Mus musculus Mus musculus T/V 1.22 None 10.1021/jm960361i
Mus musculus NIH3T3 Activity 79.18 % 10.1016/j.ejmech.2011.07.048
Mus musculus NIH3T3 Activity 102.91 % 10.1016/j.ejmech.2011.07.048
Mus musculus NIH3T3 Inhibition 11.2 % 10.1021/jm800403b
Mus musculus NIH3T3 Intrinsic Toxicity 4.5 None 10.1021/jm058003f
Mus musculus NIH3T3 Intrinsic Toxicity 10.4 None 10.1021/jm058003f
Mus musculus NIH3T3 Intrinsic Toxicity 16.5 None 10.1021/jm058003f
Mus musculus NIH3T3 Intrinsic Toxicity 21.9 None 10.1021/jm058003f
Mus musculus NIH3T3 Intrinsic Toxicity 23.33 None 10.1021/jm058003f
Mus musculus NIH3T3 Intrinsic Toxicity 31.7 None 10.1021/jm058003f
Mus musculus NIH3T3 Reversal ability 6.12 None 10.1021/jm058003f
Mus musculus NIH3T3 Reversal ability 6.21 None 10.1021/jm058003f
Mus musculus NIH3T3 Reversal ability 9.55 None 10.1021/jm058003f
Mus musculus NIH3T3 Reversal ability 10.2 None 10.1021/jm058003f
Mus musculus NIH3T3 Reversal ability 13.18 None 10.1021/jm058003f
Mus musculus NIH3T3 Reversal ability 18.76 None 10.1021/jm058003f
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus P388 Fold reversion 4.0 None 10.1021/jm960361i
Mus musculus P388 Viability 91.0 % 10.1021/jm960361i
Mus musculus P388/ADR IC50 0.03 None 10.1021/jm0303204
Mus musculus P388/ADR IC50 0.3 None 10.1021/jm0303204
Mus musculus P388/ADR IC50 0.5 None 10.1021/jm0303204
Mus musculus P388/ADR IC50 1.1 None 10.1021/jm0303204
Mus musculus P388/ADR IC50 1.3 None 10.1021/jm0303204
Mus musculus P388/ADR IC50 5.0 None 10.1021/jm0303204
Mus musculus P388/ADR Relative uptake 5.7 None 10.1021/jm00026a014
Mus musculus P388/S Relative uptake 1.02 None 10.1021/jm00026a014
Mus musculus P-glycoprotein 1 Activity 0.66 None 10.1016/j.bmc.2007.05.036
Mus musculus P-glycoprotein 1 Activity 7.27 None 10.1016/j.bmc.2007.05.036
Mus musculus P-glycoprotein 1 IC50 2000.0 nM 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Activity nan None 10.1016/0006-2952(92)90149-d
Mus musculus P-glycoprotein 3 Activity nan None 10.1023/a:1010984110732
Mus musculus P-glycoprotein 3 Activity nan None 10.1046/j.1440-1681.2000.03308.x
Mus musculus P-glycoprotein 3 IC50 10000.0 nM 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Km 10000.0 nM 10.1021/jm900253g
Mus musculus P-glycoprotein 3 Ratio 1.1 None 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 6.1 None 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 6.6 None 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 11.0 None 10.1021/jm900253g
Mus musculus Plasma PPB 88.0 % 10.1016/j.ejmech.2015.07.034
Mus musculus Solute carrier family 22 member 5 Activity 1.3 % 10.1124/mol.59.2.358
Mus musculus Solute carrier family 22 member 5 Activity nan None 10.1124/mol.59.2.358
Mycobacterium avium Mycobacterium avium MIC 400.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 800.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Multidrug efflux pump LfrA Activity 2000.0 FU 10.1016/j.bmc.2018.08.034
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Multidrug efflux pump LfrA FC 2.0 None 10.1016/j.bmc.2018.08.034
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Multidrug efflux pump LfrA FC 4.0 None 10.1016/j.bmc.2018.08.034
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Multidrug efflux pump LfrA FICI 1.0 None 10.1016/j.bmc.2018.08.034
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Multidrug efflux pump LfrA FICI 1.14 None 10.1016/j.bmc.2018.08.034
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Multidrug efflux pump LfrA Inhibition nan % 10.1016/j.bmc.2018.08.034
Mycobacterium tuberculosis Mycobacterium tuberculosis FC 4.0 None 10.1016/j.bmcl.2014.05.022
Mycobacterium tuberculosis Mycobacterium tuberculosis FC 4.0 None 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis FC 64.0 None 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis FC 128.0 None 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis FICI 0.5 None 10.1016/j.bmcl.2014.05.022
Mycobacterium tuberculosis Mycobacterium tuberculosis GI nan None 10.1016/j.bmcl.2016.11.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.00078 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.0125 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.0156 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.05 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.05 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.1 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.1 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.195 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.781 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.12 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 12.5 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 12.5 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 125.0 ug.mL-1 10.1016/j.ejmech.2020.112175
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 128.0 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 512.0 ug.mL-1 10.1021/acs.jmedchem.5b00428
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 512000.0 nM 10.1016/j.ejmech.2021.114066
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 0.0021 uM 10.1016/j.bmcl.2014.05.022
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 500.0 uM 10.1016/j.bmcl.2014.05.022
Mycobacterium tuberculosis Mycobacterium tuberculosis Ratio 4.0 None 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis Ratio 8.0 None 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis Ratio 16.0 None 10.1016/j.ejmech.2015.10.054
Mycobacterium tuberculosis Mycobacterium tuberculosis RFU 1.94 None 10.1021/acs.jmedchem.5b00428
Mycolicibacterium smegmatis Mycolicibacterium smegmatis FICI 0.552 None 10.1016/j.ejmech.2013.06.024
Mycolicibacterium smegmatis Mycolicibacterium smegmatis FICI 0.63 None 10.1016/j.ejmech.2013.06.024
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 300.0 ug.mL-1 10.1016/j.bmc.2018.08.034
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 300.0 ug.mL-1 10.1016/j.ejmech.2013.06.024
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 512.0 ug.mL-1 10.1016/j.bmc.2012.02.039
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 776.0 ug.mL-1 10.1016/j.ejmech.2015.10.054
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 800.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 800.0 ug.mL-1 10.1021/acs.jmedchem.5b00428
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Jejunum Inhibition 67.5 % 10.1007/s00044-011-9601-9
Oryctolagus cuniculus Oryctolagus cuniculus Activity 6.51 % 10.1016/s0960-894x(98)00075-4
Oryctolagus cuniculus Oryctolagus cuniculus Change -89.0 % 10.1021/jm00398a023
Oryctolagus cuniculus Oryctolagus cuniculus Change -30.0 % 10.1021/jm00398a023
Oryctolagus cuniculus Oryctolagus cuniculus Change -22.0 % 10.1021/jm00398a023
Oryctolagus cuniculus Oryctolagus cuniculus Change -18.0 % 10.1021/jm00398a023
Oryctolagus cuniculus Oryctolagus cuniculus EC30 8.7 M 10.1021/jm00400a006
Oryctolagus cuniculus Oryctolagus cuniculus IC50 300.0 nM 10.1021/jm00387a008
Oryctolagus cuniculus Oryctolagus cuniculus ID50 6.8e-09 M 10.1021/jm00360a001
Oryctolagus cuniculus Oryctolagus cuniculus ID50 3e-08 M 10.1021/jm00360a001
Oryctolagus cuniculus Oryctolagus cuniculus ID50 1.7e-07 M 10.1021/jm00360a001
Oryctolagus cuniculus Oryctolagus cuniculus ID50 3e-07 M 10.1021/jm00360a001
Oryctolagus cuniculus Oryctolagus cuniculus ID50 4e-07 M 10.1021/jm00360a001
Oryctolagus cuniculus Oryctolagus cuniculus ID50 0.0001 M 10.1021/jm00360a001
Oryctolagus cuniculus Oryctolagus cuniculus Kd 10.0 nM 10.1021/jm00114a009
Oryctolagus cuniculus Voltage-gated L-type calcium channel alpha-1C subunit IC50 1000.0 nM 10.1021/jm00119a026
Plasmodium chabaudi Plasmodium chabaudi Activity nan None 10.1016/j.bmcl.2011.06.085
Plasmodium falciparum Chloroquine resistance transporter FC 1.9 None 10.1021/ml5000228
Plasmodium falciparum Chloroquine resistance transporter FC 3.1 None 10.1021/ml5000228
Plasmodium falciparum Chloroquine resistance transporter IC50 30000.0 nM 10.1021/jm300802s
Plasmodium falciparum Chloroquine resistance transporter IC50 30000.0 nM 10.1021/jm300831b
Plasmodium falciparum Chloroquine resistance transporter IC50 33000.0 nM 10.1021/ml5000228
Plasmodium falciparum Chloroquine resistance transporter Inhibition 74.0 % 10.1021/jm300802s
Plasmodium falciparum Chloroquine resistance transporter Inhibition nan % 10.1021/ml5000228
Plasmodium falciparum Plasmodium falciparum Accumulation coefficient 97.0 None 10.1021/jm011046l
Plasmodium falciparum Plasmodium falciparum Activity 0.31 uM 10.1128/aac.01175-08
Plasmodium falciparum Plasmodium falciparum Activity 43.0 % 10.1021/ml5000228
Plasmodium falciparum Plasmodium falciparum Activity 46.0 % 10.1021/ml5000228
Plasmodium falciparum Plasmodium falciparum Activity 55.0 % 10.1021/ml5000228
Plasmodium falciparum Plasmodium falciparum Activity nan None 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum FIC 0.46 None 10.1021/jm010549o
Plasmodium falciparum Plasmodium falciparum FIC 0.51 None 10.1021/jm010549o
Plasmodium falciparum Plasmodium falciparum FICI 0.39 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 0.47 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 0.52 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 0.55 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 0.71 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 1.0 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 1.07 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 1.1 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 1.12 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 1.13 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 1.33 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum FICI 1.4 nM 10.1128/aac.01689-08
Plasmodium falciparum Plasmodium falciparum IC50 653.0 nM 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum IC50 800.0 nM 10.1021/jm011046l
Plasmodium falciparum Plasmodium falciparum IC50 1300.0 nM 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum IC50 2000.0 nM 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum IC50 4053.0 nM 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum IC50 7074.0 nM 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum IC50 13000.0 nM 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum IC50 13400.0 nM 10.1021/jm011046l
Plasmodium falciparum Plasmodium falciparum IC50 30000.0 nM 10.1016/j.ejmech.2011.02.026
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmcl.2016.01.052
Plasmodium falciparum Plasmodium falciparum Potency 1510.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 1694.4 nM None
Plasmodium falciparum Plasmodium falciparum Ratio IC50 0.23 None 10.1021/ml5000228
Plasmodium falciparum Plasmodium falciparum Ratio IC50 0.26 None 10.1016/j.ejmech.2011.02.026
Plasmodium falciparum Plasmodium falciparum Ratio IC50 0.53 None 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum Ratio IC50 0.65 None 10.1021/ml5000228
Plasmodium falciparum Plasmodium falciparum Ratio IC50 0.91 None 10.1021/ml5000228
Plasmodium falciparum Plasmodium falciparum Ratio IC50 0.96 None 10.1128/aac.00669-07
Plasmodium falciparum Plasmodium falciparum Reversal 57.0 % 10.1021/jm011046l
Plasmodium yoelii nigeriensis Plasmodium yoelii nigeriensis Inhibition 100.0 % 10.1021/jm000083u
Pneumocystis carinii Pneumocystis carinii IC50 nan None 10.1016/j.bmc.2010.01.068
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 2092.0 nM None
Rattus norvegicus Alpha-1a adrenergic receptor Ki 847.0 nM None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 1698.0 nM None
Rattus norvegicus Alpha-1b adrenergic receptor Ki 940.0 nM None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Aorta Activity 44.0 % 10.1021/np2001489
Rattus norvegicus Aorta Activity nan None 10.1021/jm301743b
Rattus norvegicus Aorta EC50 31.0 nM 10.1021/jm301743b
Rattus norvegicus Aorta EC50 38.0 nM 10.1021/jm301743b
Rattus norvegicus Aorta EC50 52.0 nM 10.1021/jm301743b
Rattus norvegicus Aorta EC50 350.0 nM 10.1021/jm301743b
Rattus norvegicus Aorta IC50 0.32 ug.mL-1 10.1021/np1004938
Rattus norvegicus Aorta IC50 1.41 ug.mL-1 10.1021/np1004938
Rattus norvegicus Bile salt export pump Ki 92500.0 nM 10.1124/dmd.112.047068
Rattus norvegicus Brain Fu 0.052 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Kp 2.81 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Vd 54.0 L.kg-1 10.1124/dmd.110.035998
Rattus norvegicus Brain Vdu 54.0 ml 10.1021/jm901036q
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Duodenum Inhibition 32.0 % 10.1124/dmd.110.035642
Rattus norvegicus Duodenum Inhibition 67.0 % 10.1124/dmd.110.035642
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Intestine Activity nan None 10.1124/dmd.110.035642
Rattus norvegicus Liver Activity 50.0 % 10.1124/dmd.110.035642
Rattus norvegicus Liver Activity 151.0 % 10.1124/dmd.110.035642
Rattus norvegicus Liver Drug metabolism 0.1 nmol/min/mg 10.1016/j.bmc.2017.02.029
Rattus norvegicus Liver Stability 68.0 % 10.1016/j.bmc.2017.02.029
Rattus norvegicus Liver microsomes Stability 63.0 % 10.1016/j.bmcl.2006.01.102
Rattus norvegicus Multidrug resistance protein 1 Activity nan None 10.1016/j.bmcl.2008.04.082
Rattus norvegicus Multidrug resistance protein 1 Activity nan None 10.1093/carcin/18.11.2255
Rattus norvegicus Multidrug resistance protein 1a Activity nan None 10.1007/s004240050829
Rattus norvegicus Multidrug resistance protein 1a Activity nan None 10.1016/0006-2952(95)00045-2
Rattus norvegicus Multidrug resistance protein 1a Activity nan None 10.1023/a:1016217505990
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus PC-12 Activity nan None 10.1038/nchembio.79
Rattus norvegicus Peripheral-type benzodiazepine receptor IC50 1.4 nM 10.1021/jm960162z
Rattus norvegicus Plasma AUC 1458.0 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Plasma AUC 7033.17 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Plasma Cmax 3167.55 nM 10.1124/dmd.110.035642
Rattus norvegicus Plasma Cmax 12824.18 nM 10.1124/dmd.110.035642
Rattus norvegicus Plasma Cp(f) 0.075 uM 10.1021/jm901036q
Rattus norvegicus Plasma Fu 0.093 None 10.1021/jm901371v
Rattus norvegicus Plasma Fu 0.12 None 10.1021/jm901036q
Rattus norvegicus Plasma K(p,uu,CSF) 0.11 None 10.1021/jm901036q
Rattus norvegicus Plasma logFu 0.1 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Plasma Tmax 0.5 hr 10.1124/dmd.110.035642
Rattus norvegicus Plasma Tmax 0.625 hr 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus Activity 30.3 ug/kg 10.1016/j.bmcl.2008.04.082
Rattus norvegicus Rattus norvegicus Activity 44.0 ug/kg 10.1016/j.bmcl.2008.04.082
Rattus norvegicus Rattus norvegicus Activity 55.0 ug/kg 10.1016/j.bmcl.2008.04.082
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.6b01787
Rattus norvegicus Rattus norvegicus ALB 41700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 330.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 362.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 367.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 465.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 59.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 65.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 66.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Arrhythmias times 56.7 None 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus Arrhythmias times 121.0 None 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus AST 76.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 97.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 198.5 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus AUC 231.83 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus AUC 256.17 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus AUC 297.83 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus AUC 367.0 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus AUC 451.5 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus AUC 638.5 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus AUC 692.67 ng.hr.mL-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus Average 21.0 % 10.1021/jm00387a008
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 153.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 163.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 173.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Change -22.0 % 10.1021/jm00114a009
Rattus norvegicus Rattus norvegicus Change -19.0 % 10.1021/jm00114a009
Rattus norvegicus Rattus norvegicus CHLORIDE 102.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 586.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 676.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 730.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 776.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 168.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 233.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 301.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 817.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CL 56.28 mL.min-1.kg-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus CL 74.24 mL.min-1.kg-1 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus Cmax 295.42 nM 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus Cmax 972.48 nM 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus CO2 27330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Decrease 32.0 % 10.1021/jm00387a008
Rattus norvegicus Rattus norvegicus Decrease 40.0 % 10.1021/jm00387a008
Rattus norvegicus Rattus norvegicus Decrease of SBP 24.2 mmHg 10.1021/jm00400a006
Rattus norvegicus Rattus norvegicus Decrease of SBP 83.3 mmHg 10.1021/jm00400a006
Rattus norvegicus Rattus norvegicus Delta blood pressure -46.7 mmHg 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus Delta heart rate -70.0 beats min-1 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus Depletion 0.0 % 10.1021/jm00387a008
Rattus norvegicus Rattus norvegicus Depletion 75.0 % 10.1021/jm00387a008
Rattus norvegicus Rattus norvegicus EC50 2510.0 nM 10.1021/jm00159a040
Rattus norvegicus Rattus norvegicus ED50 1.1 mg.kg-1 10.1016/j.bmcl.2005.11.043
Rattus norvegicus Rattus norvegicus Efficacy 0.3 mg kg-1 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus Efficacy 10.0 mg kg-1 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 94.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 95.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1330.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1436.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1540.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1710.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.77 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.53 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.7 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 128700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 143000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 144300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus IC50 10.0 nM 10.1021/jm00387a008
Rattus norvegicus Rattus norvegicus IC50 47.1 nM 10.1021/jm00062a015
Rattus norvegicus Rattus norvegicus IC50 47.1 nM 10.1021/jm00084a002
Rattus norvegicus Rattus norvegicus IC50 362.0 nM 10.1021/jm00159a040
Rattus norvegicus Rattus norvegicus IC50 1300.0 nM 10.1021/jm981079+
Rattus norvegicus Rattus norvegicus Inhibition 37.0 % 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus Inhibition 87.0 % 10.1021/jm00087a017
Rattus norvegicus Rattus norvegicus Inhibition rate 0.1 % 10.1021/jm00111a048
Rattus norvegicus Rattus norvegicus Inhibition rate 0.7 % 10.1021/jm00111a048
Rattus norvegicus Rattus norvegicus Inhibition rate 19.2 % 10.1021/jm00111a048
Rattus norvegicus Rattus norvegicus Kd 6.918 nM 10.1021/jm00107a009
Rattus norvegicus Rattus norvegicus LD50 8.5 mg.kg-1 10.1016/j.bmcl.2005.11.043
Rattus norvegicus Rattus norvegicus LDH 114.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 168.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 194.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 216.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7210.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10262.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11407.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12654.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Max 16.0 % 10.1021/jm00387a008
Rattus norvegicus Rattus norvegicus Max fall in blood pressure 67.0 mmHg 10.1021/jm00398a023
Rattus norvegicus Rattus norvegicus MCH 24.93 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.3 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.53 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.93 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 393300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 400300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.33 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.67 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.7 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.8 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 153.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 172.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 176.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 725.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 741.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 894.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1112.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 123.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 123.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 142.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 975670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1235670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1292330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1395330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.29 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.55 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.68 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5090000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5520000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5650000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5670000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.2 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 0.3067 hr 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus T1/2 0.3717 hr 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus T1/2 3.268 hr 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus T1/2 3.745 hr 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tmax 0.3617 hr 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus Tmax 0.5667 hr 10.1124/dmd.110.035642
Rattus norvegicus Rattus norvegicus URATE 13.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8200.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 3020.0 nM None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 1726.0 nM None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Solute carrier family 22 member 4 Activity 20.0 % 10.1016/s0005-2736(00)00189-9
Rattus norvegicus Solute carrier organic anion transporter family member 1A1 Activity 3.93 % 10.1023/a:1014264614637
Rattus norvegicus Solute carrier organic anion transporter family member 1A4 Activity 4.12 % 10.1023/a:1014264614637
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 398.1 nM None
Rattus norvegicus Thoracic aorta Activity 83.3 % 10.1021/np100216k
Rattus norvegicus Thoracic aorta EC50 31.0 nM 10.1016/j.ejmech.2014.04.024
Rattus norvegicus Thoracic aorta EC50 35.0 nM 10.1016/j.ejmech.2014.04.024
Rattus norvegicus Thoracic aorta EC50 38.0 nM 10.1016/j.ejmech.2014.04.024
Rattus norvegicus Thoracic aorta EC50 50.0 nM 10.1016/j.ejmech.2017.12.071
Rattus norvegicus Thoracic aorta EC50 52.0 nM 10.1016/j.ejmech.2014.04.024
Rattus norvegicus Thoracic aorta EC50 60.0 nM 10.1016/j.ejmech.2017.12.071
Rattus norvegicus Thoracic aorta EC50 70.0 nM 10.1016/j.ejmech.2017.12.071
Rattus norvegicus Thoracic aorta Inhibition nan % 10.1016/j.ejmech.2014.04.024
Rattus norvegicus Trachea EC50 890.0 nM 10.1016/j.ejmech.2017.12.071
Rattus norvegicus Trachea Emax nan None 10.1016/j.ejmech.2017.12.071
Rattus norvegicus Trachea/thoracic aorta Ratio EC50 28.7 None 10.1016/j.ejmech.2017.12.071
Rattus norvegicus Voltage-gated L-type calcium channel AUC 0.0 None 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel Emax 98.5 % 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel Emax 99.3 % 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel Emax 99.8 % 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel Emax 100.0 % 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel Emax nan None 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel IC50 3.7 nM 10.1021/jm00022a005
Rattus norvegicus Voltage-gated L-type calcium channel IC50 3.7 nM 10.1021/jm960162z
Rattus norvegicus Voltage-gated L-type calcium channel IC50 79.43 nM 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel IC50 398.11 nM 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel IC50 481.0 nM 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel IC50 1584.89 nM 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel Inhibition nan % 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel Ki 1.4 nM 10.1021/jm00022a005
Rattus norvegicus Voltage-gated L-type calcium channel pIC50 nan None 10.1021/np500076v
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit IC50 39.0 nM 10.1021/jm960162z
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1S subunit Ki 58.0 nM 10.1021/jm960361i
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 0.0 mm 10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 9.0 mm 10.1016/j.ejmech.2010.07.050
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 21.8 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1784 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.13 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 10.0 % 10.1101/2020.04.13.039917
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 15.0 % 10.1101/2020.04.13.039917
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 50.0 % 10.1101/2020.04.13.039917
Sindbis virus Sindbis virus EC50 1300000.0 nM 10.1016/j.bmc.2007.01.040
Staphylococcus aureus Quinolone resistance protein norA FC 2.0 None 10.1016/j.bmc.2008.09.042
Staphylococcus aureus Quinolone resistance protein norA FC 2.0 None 10.1016/j.ejmech.2010.05.006
Staphylococcus aureus Quinolone resistance protein norA FC 4.0 None 10.1016/j.bmc.2021.116580
Staphylococcus aureus Quinolone resistance protein norA FC 8.0 None 10.1016/j.bmc.2021.116580
Staphylococcus aureus Quinolone resistance protein norA FICI 0.625 None 10.1016/j.bmc.2021.116580
Staphylococcus aureus Quinolone resistance protein norA FICI 0.75 None 10.1016/j.bmc.2021.116580
Staphylococcus aureus Quinolone resistance protein norA FICI 1.0 None 10.1016/j.bmc.2012.05.025
Staphylococcus aureus Quinolone resistance protein norA Flu intensity 189.2 None 10.1016/j.bmc.2021.116580
Staphylococcus aureus Quinolone resistance protein norA Flu intensity 1592.0 None 10.1016/j.bmc.2021.116580
Staphylococcus aureus Quinolone resistance protein norA Inhibition nan % 10.1016/j.bmc.2012.05.025
Staphylococcus aureus Quinolone resistance protein norA MEC 50.0 ug ml-1 10.1016/j.ejmech.2010.05.006
Staphylococcus aureus Quinolone resistance protein norA MIC 2.0 ug.mL-1 10.1016/j.bmc.2008.05.030
Staphylococcus aureus Quinolone resistance protein norA MIC 6.2 ug.mL-1 10.1016/j.bmc.2021.116580
Staphylococcus aureus Quinolone resistance protein norA MIC 12.5 ug.mL-1 10.1016/j.bmc.2021.116580
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00090-07
Staphylococcus aureus Staphylococcus aureus FC 2.0 None 10.1007/s00044-012-0401-7
Staphylococcus aureus Staphylococcus aureus log10cfu 1.5 None 10.1128/aac.00090-07
Staphylococcus aureus Staphylococcus aureus MEC 50.0 ug ml-1 10.1007/s00044-012-0401-7
Staphylococcus aureus Staphylococcus aureus MIC 400.0 ug.mL-1 10.1016/j.bmc.2021.116580
Sus scrofa Beta-1 adrenergic receptor ED50 3.0 mg.kg-1 10.1021/jm00387a008
Sus scrofa Beta-2 adrenergic receptor ED50 3.0 mg.kg-1 10.1021/jm00387a008
Sus scrofa LLC-PK1 Papp 39.0 ucm/s 10.1021/acs.jmedchem.5b01372
Sus scrofa Muscarinic acetylcholine receptor M2 EC50 30974.19 nM 10.1021/jm021077w
Toxoplasma gondii Toxoplasma gondii IC50 nan None 10.1016/j.bmc.2010.01.068
Trichomonas vaginalis Trichomonas vaginalis IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei Trypanosoma brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma cruzi Cruzipain Inhibition nan % 10.1016/j.ejmech.2015.01.065
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1016/j.bmc.2010.01.068
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) Glycoprotein IC50 200000.0 nM 10.1039/C7MD00424A
None ADMET Activity 10.0 % 10.1016/j.ejmech.2012.02.034
None ADMET Activity 76.9 % 10.1021/acs.jmedchem.5b01429
None ADMET Activity 80.8 % 10.1021/np500903a
None ADMET Activity 96.0 % 10.1021/np500903a
None ADMET Activity nan None 10.1016/j.ejmech.2014.10.072
None ADMET Biotransformation nan None 10.1038/s41586-019-1291-3
None ADMET BPR 0.34 None 10.1021/jm901036q
None ADMET CC50 27000.0 nM 10.1021/acs.jmedchem.5b01429
None ADMET CC50 60000.0 nM 10.1021/acs.jmedchem.5b01429
None ADMET CC50 1000000.0 nM 10.1016/j.bmc.2007.01.040
None ADMET CL 0.0 mL.min-1.g-1 10.1016/j.ejmech.2014.02.003
None ADMET CL 2.6e-05 mL.min-1.g-1 10.1124/dmd.111.039180
None ADMET CL 0.074 uL/min 10.1124/dmd.111.039180
None ADMET CL 0.0856 mL.min-1.kg-1 10.1016/j.ejmech.2021.113719
None ADMET CL 0.1 mL.min-1.g-1 10.1124/dmd.110.035642
None ADMET CL 0.1004 mL.min-1.kg-1 10.1016/j.ejmech.2021.113719
None ADMET CL 0.12 mL.min-1.g-1 10.1124/dmd.110.035642
None ADMET CL 0.1925 mL.min-1.kg-1 10.1016/j.ejmech.2021.113719
None ADMET CL 0.43 mL.min-1.g-1 10.1124/dmd.110.035642
None ADMET CL 1.0 mL.min-1.g-1 10.1016/j.ejmech.2014.02.003
None ADMET CL 1.42 mL.min-1.g-1 10.1124/dmd.110.035642
None ADMET CL 8.0 mL.min-1.kg-1 10.1016/j.bmc.2010.10.052
None ADMET CL 9.6 mL.min-1.g-1 10.1021/acs.jmedchem.7b00392
None ADMET CL 11.57 mL.min-1.kg-1 10.1016/j.ejmech.2018.12.059
None ADMET CL 12.41 mL.min-1.kg-1 10.1021/acs.jmedchem.8b00827
None ADMET CL 12.41 mL.min-1.kg-1 10.1021/acs.jmedchem.9b00706
None ADMET CL 12.8 mL.min-1.g-1 10.1016/j.bmc.2017.09.037
None ADMET CL 13.7 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 18.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 19.61 mL.min-1.kg-1 10.1016/j.ejmech.2015.07.034
None ADMET CL 26.3 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 36.18 mL.min-1.kg-1 10.1021/acs.jmedchem.8b00827
None ADMET CL 36.18 mL.min-1.kg-1 10.1021/acs.jmedchem.9b00706
None ADMET CL 37.1 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 37.3 mL.min-1.kg-1 10.1021/acs.jmedchem.9b01462
None ADMET CL 40.4 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 40.82 mL.min-1.kg-1 10.1016/j.ejmech.2018.12.059
None ADMET CL 47.3 mL.min-1.kg-1 10.1021/acs.jmedchem.9b01462
None ADMET CL 54.0 mL.min-1.g-1 10.1021/acs.jmedchem.7b00067
None ADMET CL 57.0 mL.min-1.g-1 10.1016/j.ejmech.2020.112416
None ADMET CL 60.0 mL.min-1.g-1 10.1016/j.ejmech.2020.112416
None ADMET CL 60.66 mL.min-1.kg-1 10.1021/acs.jmedchem.8b00827
None ADMET CL 60.66 mL.min-1.kg-1 10.1021/acs.jmedchem.9b00706
None ADMET CL 62.2 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 65.65 mL.min-1.kg-1 10.1016/j.ejmech.2015.07.034
None ADMET CL 87.3 mL.min-1.g-1 10.1021/acs.jmedchem.1c01202
None ADMET CL 104.71 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 109.4 mL.min-1.g-1 10.1016/j.ejmech.2019.111857
None ADMET CL 116.0 mL.min-1.g-1 10.1021/acs.jmedchem.7b00392
None ADMET CL 122.0 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
None ADMET CL 126.0 mL.min-1.kg-1 10.1016/j.bmc.2010.10.052
None ADMET CL 127.7 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET CL 128.8 mL.min-1.g-1 10.1016/j.ejmech.2021.113453
None ADMET CL 135.0 mL.min-1.g-1 10.1016/j.bmc.2017.09.037
None ADMET CL 147.6 mL.min-1.g-1 10.1021/acsmedchemlett.3c00039
None ADMET CL 155.0 mL.min-1.g-1 10.1021/acs.jmedchem.1c01202
None ADMET CL 161.9 mL.min-1.g-1 10.1021/acs.jmedchem.9b00728
None ADMET CL 172.9 mL.min-1.g-1 10.1021/acsmedchemlett.3c00039
None ADMET CL 177.0 mL.min-1.g-1 10.1021/acs.jmedchem.1c01202
None ADMET CL 181.0 mL.min-1.g-1 10.1016/j.ejmech.2017.11.055
None ADMET CL 192.0 mL.min-1.g-1 10.1016/j.bmc.2018.05.003
None ADMET CL 209.0 mL.min-1.g-1 10.1016/j.ejmech.2014.02.003
None ADMET CL 211.1 mL.min-1.g-1 10.1016/j.ejmech.2020.112497
None ADMET CL 273.93 mL.min-1.g-1 10.1016/j.ejmech.2021.113453
None ADMET CL 286.6 mL.min-1.g-1 10.1016/j.ejmech.2018.02.031
None ADMET CL 310.0 mL.min-1.kg-1 10.1124/dmd.111.042309
None ADMET CL 500.0 mL.min-1.kg-1 10.1021/acs.jmedchem.0c00628
None ADMET CL 649.0 mL.min-1.g-1 10.1016/j.ejmech.2014.02.003
None ADMET CL 763.0 mL.min-1.kg-1 10.1016/j.bmc.2010.10.052
None ADMET CL 26900.0 mL.min-1.g-1 10.1021/acs.jmedchem.1c01255
None ADMET CLH 2.0 uL/min 10.1016/j.ejmech.2020.112416
None ADMET CLH 3.0 uL/min 10.1016/j.ejmech.2020.112416
None ADMET CLH 33.3 ml/(min.mg) 10.1021/acs.jmedchem.1c00715
None ADMET CLH 52.91 uL/min 10.1021/acs.jmedchem.0c00456
None ADMET CLH 63.3 uL/min 10.1021/acs.jmedchem.8b01957
None ADMET CLH 73.0 uL/min 10.1021/acs.jmedchem.7b01465
None ADMET CLH 77.0 uL/min 10.1021/acsmedchemlett.9b00471
None ADMET CLH 93.9 uL/min 10.1021/acs.jmedchem.7b01465
None ADMET CLH 99.1 uL/min 10.1021/acs.jmedchem.7b01465
None ADMET CLH 130.0 uL/min 10.1016/j.ejmech.2016.04.052
None ADMET CLH 145.8 ml/(min.mg) 10.1021/acs.jmedchem.1c00715
None ADMET CLH 204.0 uL/min 10.1016/j.ejmech.2020.112465
None ADMET Compound recovery 70.0 % 10.1124/dmd.110.036988
None ADMET Cytotoxicity 695.0 uM 10.1021/jm011046l
None ADMET delta logD -0.89 None 10.1021/jm0000564
None ADMET Drugabsorption 91.4 % 10.1016/j.ejmech.2020.112492
None ADMET Drug metabolism 76.0 % 10.1016/j.ejmech.2021.113783
None ADMET Drug recovery 23.0 % 10.1021/acs.jmedchem.5b01962
None ADMET EFTPC 53.0 nM 10.1093/cvr/cvr044
None ADMET F 22.0 % 10.1021/jm010152k
None ADMET F 49.0 % 10.1021/jm0000564
None ADMET Fu 0.011 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.049 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.1 None 10.1021/jm030408h
None ADMET Fu 0.12 None 10.1124/dmd.111.042309
None ADMET Fu 0.137 None 10.1124/dmd.110.036988
None ADMET Fu 0.154 None 10.1124/dmd.110.036988
None ADMET Fu 0.16 None 10.1124/dmd.110.036988
None ADMET Fu 0.233 None 10.1124/dmd.110.036988
None ADMET GI 10.0 % 10.1016/j.bmc.2012.02.050
None ADMET IC50 51.33 ug.mL-1 10.1016/j.ejmech.2015.10.054
None ADMET IC50 55000.0 nM 10.1128/aac.00669-07
None ADMET IC50 56240.0 nM 10.1016/j.bmc.2016.03.065
None ADMET Inhibition 19.6 % 10.1021/jm800403b
None ADMET K 0.0235 /min 10.1021/acs.jmedchem.6b00605
None ADMET Kel 1.9e-05 /min 10.1021/acs.jmedchem.9b01963
None ADMET Km 13210.0 nM 10.1124/dmd.110.035642
None ADMET Km 16090.0 nM 10.1124/dmd.110.035642
None ADMET KmH 34.06 uM 10.1124/dmd.110.035642
None ADMET KmH 55.37 uM 10.1124/dmd.110.035642
None ADMET KmL 1041.37 uM 10.1124/dmd.110.035642
None ADMET KmL 1388.66 uM 10.1124/dmd.110.035642
None ADMET K(p,uu,brain) 0.053 None 10.1021/jm901036q
None ADMET K(p,uu,brain) 1.86 None 10.1021/acs.jmedchem.0c02011
None ADMET LD50 962.0 mg.kg-1 10.1016/j.bmc.2014.09.023
None ADMET logPapp -4.8 None 10.1124/dmd.111.041665
None ADMET LogP app -4.68 None 10.1016/j.bmc.2007.03.040
None ADMET LogP app -4.64 None 10.1016/j.bmc.2007.03.040
None ADMET LogP app -4.31 None 10.1016/j.bmc.2007.03.040
None ADMET LogP app -4.13 None 10.1016/j.bmc.2007.03.040
None ADMET LogP app -3.96 None 10.1016/j.bmc.2007.03.040
None ADMET log Pe -5.93 None 10.1021/jm300460c
None ADMET log Pe -5.93 None 10.1021/ml400462j
None ADMET log Pe -5.17 None 10.1016/j.ejmech.2020.112282
None ADMET log Pe -3.5 None 10.1016/j.bmc.2015.03.051
None ADMET logPeff -4.1 None 10.1016/j.bmc.2016.11.032
None ADMET logPeff -3.9 None 10.1016/j.ejmech.2016.08.016
None ADMET logP(lung) 1.7 None 10.1016/j.ejmech.2007.04.002
None ADMET logPm -0.2 None 10.1016/j.bmc.2007.03.040
None ADMET MRT 3.4 hr 10.1124/dmd.108.020479
None ADMET Papp 2.73 None 10.1021/jm7012826
None ADMET Papp 4.3 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 4.6 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 7.2 cm s-1 10.1021/jm049661n
None ADMET Papp 8.1 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 9.0 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 14.0 10'-6 cm/s 10.1021/acs.jmedchem.8b00172
None ADMET Papp 16.6 cm s-1 10.1021/jm049661n
None ADMET Papp 22.7 10^-6 cm/s 10.1016/j.ejmech.2021.113630
None ADMET Papp 29.0 10'-6 cm/s 10.1021/acs.jmedchem.8b00172
None ADMET Papp 38.0 10^-6 cm/s 10.1016/j.ejmech.2021.113630
None ADMET Papp 110.44 10^-6 cm/s 10.1016/j.bmc.2007.03.040
None ADMET Papp 169.0 10^-6 cm/s 10.1021/acs.jmedchem.1c00607
None ADMET Papp e-6 69.4 cm s-1 10.1021/jm010152k
None ADMET Peff 1.85 10^-5cm/s 10.1016/j.ejmech.2020.112765
None ADMET Peff 12.21 ucm/s 10.1016/j.bmc.2014.08.035
None ADMET Peff 13.1 10'-6 cm/s 10.1016/j.ejmech.2016.07.052
None ADMET Peff 13.31 10'-6 cm/s 10.1016/j.bmcl.2014.12.034
None ADMET Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2015.01.005
None ADMET Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2016.08.036
None ADMET Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2016.07.052
None ADMET Peff 16.0 10'-6 cm/s 10.1039/C6MD00053C
None ADMET Peff 16.0 10^-6 cm/s 10.1016/j.bmc.2020.115940
None ADMET Peff 16.0 10^-6 cm/s 10.1016/j.bmc.2022.116878
None ADMET Peff 16.0 10^-6 cm/s 10.1016/j.ejmech.2020.112751
None ADMET Peff 16.0 ucm/s 10.1016/j.ejmech.2015.10.007
None ADMET Peff 16.0 ucm/s 10.1021/jm201463v
None ADMET Peff 16.9 10'-6 cm/s 10.1016/j.bmc.2015.01.005
None ADMET Peff 18.45 ucm/s 10.1016/j.ejmech.2011.04.016
None ADMET Peff 18.6 10'-6 cm/s 10.1039/C6MD00053C
None ADMET Peff 19.6 ucm/s 10.1016/j.bmcl.2016.03.086
None ADMET Peff 21.2 10'-6 cm/s 10.1016/j.ejmech.2014.09.081
None ADMET Peff 21.2 10^-6 cm/s 10.1016/j.bmc.2022.116878
None ADMET Peff 25.2 10'-6 cm/s 10.1016/j.bmc.2014.07.053
None ADMET Peff 25.3 10'-6 cm/s 10.1016/j.bmcl.2014.10.025
None ADMET Peff 25.8 ucm/s 10.1016/j.ejmech.2015.10.007
None ADMET Peff 28.4 10'-6 cm/s 10.1016/j.bmc.2016.08.036
None ADMET permeability 1.85 10^-5cm/s 10.1021/acs.jmedchem.0c02009
None ADMET permeability 6.45 10^-6 cm/s 10.1016/j.ejmech.2020.112492
None ADMET permeability 6.7 10'-4 cm/s 10.1021/jm901846t
None ADMET permeability 7.4 10^-6 cm/s 10.1016/j.ejmech.2020.112492
None ADMET permeability 8.18 10^-6 cm/s 10.1016/j.ejmech.2020.112492
None ADMET permeability 10.0 10^-6 cm/s 10.1021/acs.jmedchem.1c00472
None ADMET permeability 10.2 ucm/s 10.1016/j.ejmech.2013.02.007
None ADMET permeability 12.0 10^-6 cm/s 10.1016/j.ejmech.2021.113554
None ADMET permeability 12.6 10'-6 cm/s 10.1021/jm801292b
None ADMET permeability 12.8 10^-6 cm/s 10.1016/j.ejmech.2021.113713
None ADMET permeability 13.0 10'-6 cm/s 10.1016/j.ejmech.2015.01.058
None ADMET permeability 13.2 10'-6 cm/s 10.1016/j.bmc.2016.07.025
None ADMET permeability 13.2 10^-6 cm/s 10.1016/j.bmcl.2022.128602
None ADMET permeability 13.4 10'-6 cm/s 10.1016/j.ejmech.2015.08.057
None ADMET permeability 14.39 10^-6 cm/s 10.1016/j.ejmech.2021.113428
None ADMET permeability 15.03 10^-6 cm/s 10.1021/acs.jmedchem.0c01504
None ADMET permeability 15.2 10'-6 cm/s 10.1016/j.ejmech.2011.10.040
None ADMET permeability 15.4 ucm/s 10.1016/j.ejmech.2012.09.044
None ADMET permeability 15.6 ucm/s 10.1016/j.ejmech.2011.12.016
None ADMET permeability 16.0 10'-6 cm/s 10.1016/j.bmc.2016.11.048
None ADMET permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2015.03.040
None ADMET permeability 16.0 10'-6 cm/s 10.1021/jm900859q
None ADMET permeability 16.0 10^-6 cm/s 10.1016/j.ejmech.2020.112492
None ADMET permeability 16.0 10^-6 cm/s 10.1021/acs.jmedchem.0c02145
None ADMET permeability 16.0 10^-6 cm/s 10.1039/c9md00441f
None ADMET permeability 16.0 ucm/s 10.1016/j.bmc.2013.09.050
None ADMET permeability 16.0 ucm/s 10.1016/j.bmc.2016.02.023
None ADMET permeability 16.0 ucm/s 10.1016/j.bmc.2016.04.012
None ADMET permeability 16.0 ucm/s 10.1016/j.bmc.2016.09.050
None ADMET permeability 16.0 ucm/s 10.1016/j.ejmech.2013.12.008
None ADMET permeability 16.2 ucm/s 10.1016/j.bmc.2016.12.013
None ADMET permeability 16.9 10'-6 cm/s 10.1016/j.bmc.2016.11.048
None ADMET permeability 16.9 ucm/s 10.1016/j.bmc.2013.05.043
None ADMET permeability 16.9 ucm/s 10.1016/j.bmc.2016.04.012
None ADMET permeability 17.55 10'-6 cm/s 10.1016/j.ejmech.2015.03.040
None ADMET permeability 18.21 10^-6 cm/s 10.1016/j.bmc.2022.116698
None ADMET permeability 18.4 ucm/s 10.1016/j.bmc.2016.09.050
None ADMET permeability 19.43 10^-6 cm/s 10.1016/j.ejmech.2021.113441
None ADMET permeability 20.2 10'-6 cm/s 10.1021/jm900628z
None ADMET permeability 20.2 ucm/s 10.1016/j.ejmech.2011.03.003
None ADMET permeability 20.8 10^-6 cm/s 10.1016/j.ejmech.2022.114210
None ADMET permeability 21.01 ucm/s 10.1016/j.bmc.2016.02.023
None ADMET permeability 21.2 ucm/s 10.1016/j.bmc.2013.09.050
None ADMET permeability 25.2 10'-6 cm/s 10.1016/j.ejmech.2014.07.021
None ADMET permeability 26.7 10'-6 cm/s 10.1021/jm900859q
None ADMET permeability 28.3 10'-6 cm/s 10.1021/jm900859q
None ADMET permeability 28.9 10^-6 cm/s 10.1016/j.ejmech.2022.114354
None ADMET permeability 49.9 10'6cm/s 10.1016/j.bmcl.2009.06.091
None ADMET permeability 80.46 10^-6 cm/s 10.1016/j.ejmech.2021.113405
None ADMET permeability 114.8 10^-6 cm/s 10.1016/j.ejmech.2022.114295
None ADMET permeability nan None 10.1016/j.bmc.2011.05.062
None ADMET permeability nan None 10.1021/acs.jmedchem.1c01942
None ADMET pKa 9.2 None 10.1021/jm00179a017
None ADMET PPB 86.05 % 10.6019/CHEMBL3301361
None ADMET PPB 89.27 % 10.6019/CHEMBL3301361
None ADMET PPB 89.4 % 10.1016/j.ejmech.2018.12.059
None ADMET PPB 89.91 % 10.6019/CHEMBL3301361
None ADMET PPB 91.9 % 10.1016/j.ejmech.2018.12.059
None ADMET PPB 93.41 % 10.1021/acs.jmedchem.8b01891
None ADMET PPB 97.14 % 10.1021/acs.jmedchem.8b01891
None ADMET R 7.0 % 10.1021/jm010152k
None ADMET Ratio -10.0 None 10.1124/dmd.110.034629
None ADMET Ratio -4.0 None 10.1124/dmd.110.034629
None ADMET Ratio 0.16 None 10.1016/j.ejmech.2020.112416
None ADMET Ratio 0.29 None 10.1016/j.ejmech.2020.112416
None ADMET Ratio 0.5 None 10.1124/dmd.110.034629
None ADMET Ratio 1.7 None 10.1016/j.ejmech.2021.113630
None ADMET Ratio 2.0 None 10.1021/acs.jmedchem.8b00172
None ADMET Ratio 6.0 None 10.1124/dmd.110.034629
None ADMET Ratio 6.432 None 10.1021/acs.jmedchem.0c02011
None ADMET Ratio 93.5 None 10.1016/j.ejmech.2015.01.006
None ADMET Ratio IC50/EC50 99.56 None 10.1016/j.ejmech.2022.114822
None ADMET Ratio IC50/EC50 200.1 None 10.1021/jm400930e
None ADMET Ratio IC50/EC50 208.4 None 10.1021/jm201121b
None ADMET Ratio IC50/EC50 413.14 None 10.1016/j.ejmech.2018.01.027
None ADMET Selectivity Index 200.0 None 10.1016/j.ejmech.2021.113795
None ADMET Stability 0.0 % None
None ADMET Stability 2.0 % 10.1016/j.ejmech.2014.02.003
None ADMET Stability 2.0 % 10.1021/acs.jmedchem.0c01372
None ADMET Stability 2.0 % 10.1021/acs.jmedchem.2c00972
None ADMET Stability 2.0 % 10.1021/acs.jmedchem.8b01578
None ADMET Stability 3.9 % 10.1016/j.ejmech.2017.11.055
None ADMET Stability 4.73 % 10.1021/acs.jmedchem.8b01960
None ADMET Stability 5.0 % 10.1016/j.bmcl.2016.09.070
None ADMET Stability 5.6 % 10.1016/j.ejmech.2017.11.055
None ADMET Stability 6.0 % 10.1021/jm5015742
None ADMET Stability 6.5 % 10.1021/acs.jmedchem.0c02210
None ADMET Stability 8.3 % 10.1016/j.ejmech.2021.113405
None ADMET Stability 8.4 % 10.1021/jm5015742
None ADMET Stability 9.0 % 10.1021/acs.jmedchem.0c01372
None ADMET Stability 9.0 % 10.1021/acs.jmedchem.2c00972
None ADMET Stability 9.0 % 10.1021/acs.jmedchem.8b01578
None ADMET Stability 10.0 % 10.1021/acs.jmedchem.8b00143
None ADMET Stability 10.11 % 10.1021/acs.jmedchem.8b01960
None ADMET Stability 10.5 % 10.1016/j.ejmech.2018.03.023
None ADMET Stability 13.2 % 10.1021/acs.jmedchem.1c01093
None ADMET Stability 13.6 % 10.1016/j.ejmech.2019.111733
None ADMET Stability 16.6 % 10.1021/acs.jmedchem.0c02210
None ADMET Stability 16.8 % 10.1021/acs.jmedchem.1c00110
None ADMET Stability 17.0 % 10.1016/j.ejmech.2014.02.003
None ADMET Stability 18.3 % 10.1016/j.ejmech.2022.114854
None ADMET Stability 23.93 % 10.1016/j.ejmech.2021.113931
None ADMET Stability 24.0 % 10.1021/acs.jmedchem.8b01891
None ADMET Stability 26.51 % 10.1021/acs.jmedchem.8b01960
None ADMET Stability 28.0 % 10.1021/acs.jmedchem.8b01891
None ADMET Stability 30.0 % 10.1016/j.ejmech.2021.113397
None ADMET Stability 56.0 % 10.1021/acs.jmedchem.7b00067
None ADMET Stability 89.4 % 10.1021/jm5015742
None ADMET Stability 96.0 % 10.1016/j.ejmech.2014.02.003
None ADMET Stability 96.5 % 10.1021/jm5015742
None ADMET Stability 98.0 % 10.1016/j.ejmech.2014.02.003
None ADMET Stability 99.56 % 10.1021/acs.jmedchem.9b01963
None ADMET Stability 100.0 % 10.1021/acs.jmedchem.2c01170
None ADMET Stability 100.0 % 10.1021/acs.jmedchem.8b01960
None ADMET Stability 108.0 % None
None ADMET Stability 110.0 % 10.1016/j.ejmech.2014.02.003
None ADMET Stability 111.0 % 10.1016/j.ejmech.2014.02.003
None ADMET t1/2 nan None 10.1016/j.ejmech.2020.112427
None ADMET T1/2 0.045 hr 10.1021/acs.jmedchem.8b01960
None ADMET T1/2 0.05667 hr 10.1016/j.ejmech.2020.112465
None ADMET T1/2 0.06 hr 10.1016/j.ejmech.2014.02.003
None ADMET T1/2 0.065 hr 10.1039/D1MD00292A
None ADMET T1/2 0.06533 hr 10.1021/acs.jmedchem.1c01202
None ADMET T1/2 0.07 hr 10.1016/j.ejmech.2020.112427
None ADMET T1/2 0.0745 hr 10.1021/acs.jmedchem.1c01202
None ADMET T1/2 0.075 hr 10.1016/j.bmcl.2018.07.019
None ADMET T1/2 0.07667 hr 10.1016/j.bmc.2010.10.052
None ADMET T1/2 0.09167 hr 10.1021/acs.jmedchem.2c00386
None ADMET T1/2 0.095 hr 10.1016/j.bmcl.2018.01.053
None ADMET T1/2 0.095 hr 10.1021/acsmedchemlett.2c00265
None ADMET T1/2 0.1 hr 10.1016/j.ejmech.2021.113719
None ADMET T1/2 0.1067 hr 10.1021/acs.jmedchem.2c00386
None ADMET T1/2 0.12 hr 10.1016/j.bmc.2018.05.003
None ADMET T1/2 0.125 hr 10.1016/j.bmcl.2018.01.053
None ADMET T1/2 0.1323 hr 10.1021/acs.jmedchem.1c01202
None ADMET T1/2 0.1433 hr 10.1021/acs.jmedchem.9b00728
None ADMET T1/2 0.1667 hr 10.1016/j.bmc.2018.07.034
None ADMET T1/2 0.1783 hr 10.1016/j.ejmech.2016.04.052
None ADMET T1/2 0.1833 hr 10.1016/j.ejmech.2014.02.003
None ADMET T1/2 0.1917 hr 10.1039/D1MD00292A
None ADMET T1/2 0.195 hr 10.1016/j.bmcl.2018.01.053
None ADMET T1/2 0.2 hr 10.1016/j.ejmech.2021.113719
None ADMET T1/2 0.2117 hr 10.1016/j.ejmech.2021.113453
None ADMET T1/2 0.2167 hr 10.1016/j.ejmech.2019.111857
None ADMET T1/2 0.23 hr 10.1021/acs.jmedchem.9b00219
None ADMET T1/2 0.2333 hr 10.1021/acs.jmedchem.7b01465
None ADMET T1/2 0.25 hr 10.1021/acs.jmedchem.7b01465
None ADMET T1/2 0.2517 hr 10.1016/j.ejmech.2020.112427
None ADMET T1/2 0.2683 hr 10.1021/acs.jmedchem.0c02210
None ADMET T1/2 0.285 hr 10.1016/j.bmc.2017.09.037
None ADMET T1/2 0.2983 hr 10.1016/j.bmcl.2019.04.029
None ADMET T1/2 0.3 hr 10.1016/j.bmc.2010.10.052
None ADMET T1/2 0.3 hr 10.1016/j.bmcl.2016.05.054
None ADMET T1/2 0.3 hr 10.1016/j.ejmech.2021.113719
None ADMET T1/2 0.3 hr 10.1021/acs.jmedchem.0c01967
None ADMET T1/2 0.3 hr 10.1021/acsmedchemlett.9b00471
None ADMET T1/2 0.32 hr 10.1021/acsmedchemlett.2c00265
None ADMET T1/2 0.33 hr 10.1021/acs.jmedchem.7b00392
None ADMET T1/2 0.3367 hr 10.1021/acs.jmedchem.1c01255
None ADMET T1/2 0.3383 hr 10.1016/j.bmc.2015.08.014
None ADMET T1/2 0.35 hr 10.1016/j.bmcl.2017.05.040
None ADMET T1/2 0.365 hr 10.1021/acs.jmedchem.8b01957
None ADMET T1/2 0.37 hr 10.1021/acs.jmedchem.0c02210
None ADMET T1/2 0.3833 hr 10.1016/j.ejmech.2020.112416
None ADMET T1/2 0.39 hr 10.1021/acs.jmedchem.1c00715
None ADMET T1/2 0.4 hr 10.1016/j.ejmech.2020.112416
None ADMET T1/2 0.4033 hr 10.1016/j.ejmech.2018.02.031
None ADMET T1/2 0.4033 hr 10.1016/j.ejmech.2020.112497
None ADMET T1/2 0.4083 hr 10.1016/j.bmcl.2019.04.029
None ADMET T1/2 0.4167 hr 10.1021/acs.jmedchem.6b00605
None ADMET T1/2 0.4365 hr 10.1021/acs.jmedchem.0c00456
None ADMET T1/2 0.4483 hr 10.1016/j.ejmech.2021.113453
None ADMET T1/2 0.45 hr 10.1021/acs.jmedchem.7b01465
None ADMET T1/2 0.5183 hr 10.1016/j.bmcl.2019.04.029
None ADMET T1/2 0.62 hr 10.1021/acs.jmedchem.1c00715
None ADMET T1/2 0.6217 hr 10.1021/acs.jmedchem.9b01462
None ADMET T1/2 0.8483 hr 10.1021/acs.jmedchem.9b01462
None ADMET T1/2 0.86 hr 10.1016/j.bmcl.2018.01.053
None ADMET T1/2 0.87 hr 10.1016/j.ejmech.2015.07.034
None ADMET T1/2 0.94 hr 10.1021/acs.jmedchem.8b00827
None ADMET T1/2 0.94 hr 10.1021/acs.jmedchem.9b00706
None ADMET T1/2 1.06 hr 10.1016/j.ejmech.2015.07.034
None ADMET T1/2 1.067 hr 10.1021/acs.jmedchem.7b00067
None ADMET T1/2 1.29 hr 10.1021/acs.jmedchem.8b00827
None ADMET T1/2 1.29 hr 10.1021/acs.jmedchem.9b00706
None ADMET T1/2 1.4 hr 10.1016/j.ejmech.2018.12.059
None ADMET T1/2 1.68 hr 10.1021/acs.jmedchem.8b00827
None ADMET T1/2 1.68 hr 10.1021/acs.jmedchem.9b00706
None ADMET T1/2 1.8 hr 10.1016/j.ejmech.2018.12.059
None ADMET T1/2 2.8 hr 10.1124/dmd.108.020479
None ADMET T1/2 3.0 hr 10.1016/j.bmc.2015.08.014
None ADMET T1/2 3.0 hr 10.1016/j.bmc.2017.09.037
None ADMET T1/2 3.0 hr 10.1016/j.ejmech.2014.02.003
None ADMET T1/2 4.0 hr 10.1021/acs.jmedchem.2c01170
None ADMET T1/2 4.0 hr 10.1021/acs.jmedchem.7b00392
None ADMET T1/2 4.0 hr 10.1021/acs.jmedchem.9b01963
None ADMET T1/2 4.5 hr 10.1021/acs.jmedchem.2c00203
None ADMET T1/2 4.8 hr 10.1016/j.ejmech.2020.112416
None ADMET T1/2 10.55 hr 10.1016/j.ejmech.2020.112416
None ADMET T1/2 11.1 hr 10.1021/acs.jmedchem.2c00203
None ADMET Vdss 2.99 mL/min/kg 10.1124/dmd.105.006619
None ADMET Vdss 3.7 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 4.47 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 4.5 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 4.68 L.kg-1 10.1021/jm030408h
None ADMET Vdss 5.5 L.kg-1 10.1124/dmd.105.006619
None ADMET Vmax 1.6 nmol/min/mg 10.1124/dmd.110.035642
None ADMET Vmax 2.38 nmol/min/mg 10.1124/dmd.110.035642
None ADMET VmaxH 22.7 pmol/min/mg 10.1124/dmd.110.035642
None ADMET VmaxH 49.04 pmol/min/mg 10.1124/dmd.110.035642
None ADMET Vmax/Km 0.122 ml/min/mg 10.1124/dmd.110.035642
None ADMET Vmax/Km 0.149 ml/min/mg 10.1124/dmd.110.035642
None ADMET Vmax/Km 0.53 microL/min/mg 10.1124/dmd.110.035642
None ADMET Vmax/Km 1.11 ml/min 10.1124/dmd.110.035642
None ADMET Vmax/Km 1.13 uL/min 10.1124/dmd.110.035642
None ADMET Vmax/Km 1.261 ml/min 10.1124/dmd.110.035642
None ADMET Vmax/Km 1.54 microL/min/mg 10.1124/dmd.110.035642
None ADMET Vmax/Km 5.382 uL/min 10.1124/dmd.110.035642
None ADMET VmaxL 122.41 pmol/min/mg 10.1124/dmd.110.035642
None ADMET VmaxL 139.23 pmol/min/mg 10.1124/dmd.110.035642
None Erythrocyte FC 3.0 None 10.1016/j.bmc.2011.11.060
None Heme Activity nan None 10.1038/nchembio806
None Heme Inhibition nan % 10.1038/nchembio806
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 0.7 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 2.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.1 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity LTKB_BD DILI severity score 4.0 None 10.1016/j.drudis.2011.05.007
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 0.3 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 0.3 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Liposome Other 780.0 None 10.1021/jm991156g
None Liposome Other 1056.0 None 10.1021/jm991156g
None Lymphoma cell line FL-1 170.3 None 10.1021/jm0111301
None Lymphoma cell line Fluorescence activity ratio 8.27 None 10.1021/jm0111301
None Lymphoma cell line FSC 569.63 None 10.1021/jm0111301
None Lymphoma cell line SSC 177.48 None 10.1021/jm0111301
None MDR Activity 114.0 % 10.1021/np070089n
None MDR Activity 138.0 % 10.1021/np070089n
None MDR IC50 63900.0 nM 10.1021/jm201121b
None Molecular identity unknown EC50 30.9 nM 10.1016/j.bmcl.2015.11.056
None Molecular identity unknown Emax 95.8 % 10.1016/j.bmcl.2015.11.056
None NON-PROTEIN TARGET Activity 0.03 None 10.1021/np9702042
None NON-PROTEIN TARGET Activity 0.06 None 10.1021/np9702042
None NON-PROTEIN TARGET Activity 0.12 None 10.1021/np9702042
None NON-PROTEIN TARGET Activity 0.15 None 10.1021/np9702042
None NON-PROTEIN TARGET Activity 0.19 None 10.1021/np9702042
None NON-PROTEIN TARGET Activity 2.1 % 10.1016/j.bmc.2010.02.040
None NON-PROTEIN TARGET Activity 33.0 % 10.1021/np800083x
None NON-PROTEIN TARGET Activity 55.95 % 10.1016/j.bmc.2010.02.040
None NON-PROTEIN TARGET Activity 60.0 % 10.1016/j.bmc.2010.02.040
None NON-PROTEIN TARGET Activity 71.0 % 10.1016/j.bmcl.2007.04.030
None NON-PROTEIN TARGET Activity 81.0 % 10.1021/np800083x
None NON-PROTEIN TARGET Activity 84.0 % 10.1016/j.bmcl.2007.04.030
None NON-PROTEIN TARGET Activity 90.0 % 10.1016/j.bmcl.2007.04.030
None NON-PROTEIN TARGET Activity 93.0 % 10.1021/np500521v
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2014.10.072
None NON-PROTEIN TARGET Activity nan None 10.1021/np960178s
None NON-PROTEIN TARGET Effect 38.2 None 10.1016/j.bmcl.2005.01.054
None NON-PROTEIN TARGET FC 2.8 None 10.1021/acs.jnatprod.6b00190
None NON-PROTEIN TARGET FC 6.0 None 10.1016/j.bmcl.2012.09.096
None NON-PROTEIN TARGET FC 72.0 None 10.1016/j.bmcl.2012.09.096
None NON-PROTEIN TARGET FC 97.0 None 10.1016/j.bmcl.2012.09.096
None NON-PROTEIN TARGET FIC 0.61 None 10.1021/jm010549o
None NON-PROTEIN TARGET FIC 0.63 None 10.1021/jm010549o
None NON-PROTEIN TARGET Fu 0.093 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.73 None 10.1021/jm401963n
None NON-PROTEIN TARGET Fu 0.79 None 10.1124/dmd.111.042309
None NON-PROTEIN TARGET GI50 31.5 ug.mL-1 10.1021/jm101249z
None NON-PROTEIN TARGET GI50 15000.0 nM 10.1016/j.bmc.2007.03.014
None NON-PROTEIN TARGET GI50 20000.0 nM 10.1016/j.bmcl.2009.07.127
None NON-PROTEIN TARGET Hepatotoxicity (acute) 4.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 16.7 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 18.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 0.69 ug.mL-1 10.1021/np980479x
None NON-PROTEIN TARGET IC50 10.0 nM 10.1016/j.bmc.2008.02.012
None NON-PROTEIN TARGET IC50 15.3 ug.mL-1 10.1021/np980479x
None NON-PROTEIN TARGET IC50 20.0 nM 10.1016/j.bmcl.2014.12.083
None NON-PROTEIN TARGET IC50 20.5 ug.mL-1 10.1021/np980479x
None NON-PROTEIN TARGET IC50 25.0 ug.mL-1 10.1021/acs.jnatprod.5b00992
None NON-PROTEIN TARGET IC50 200.0 nM 10.1016/j.bmc.2008.02.012
None NON-PROTEIN TARGET IC50 600.0 nM 10.1021/jm501676v
None NON-PROTEIN TARGET IC50 1600.0 nM 10.1021/np9804379
None NON-PROTEIN TARGET IC50 10300.0 nM 10.1021/acs.jnatprod.5b00992
None NON-PROTEIN TARGET IC50 10300.0 nM 10.1021/np500385b
None NON-PROTEIN TARGET IC50 13300.0 nM 10.1021/np500385b
None NON-PROTEIN TARGET IC50 19600.0 nM 10.1021/np500385b
None NON-PROTEIN TARGET IC50 25700.0 nM 10.1021/np500385b
None NON-PROTEIN TARGET IC50 39200.0 nM 10.1021/np9804379
None NON-PROTEIN TARGET IC50 45200.0 nM 10.1021/np9804379
None NON-PROTEIN TARGET IC50 63400.0 nM 10.1021/jm010126m
None NON-PROTEIN TARGET IC50 63800.0 nM 10.1021/acs.jmedchem.5b00085
None NON-PROTEIN TARGET IC50 63800.0 nM 10.1021/jm201121b
None NON-PROTEIN TARGET IC50 63800.0 nM 10.1021/jm400930e
None NON-PROTEIN TARGET IC50 63900.0 nM 10.1021/acs.jmedchem.5b00085
None NON-PROTEIN TARGET IC50 63900.0 nM 10.1021/jm400930e
None NON-PROTEIN TARGET IC50 65800.0 nM 10.1021/jm010126m
None NON-PROTEIN TARGET IC50 100000.0 nM 10.1016/j.bmc.2010.02.046
None NON-PROTEIN TARGET IC50 100000.0 nM 10.1016/j.bmcl.2009.05.103
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.01.068
None NON-PROTEIN TARGET Inhibition -66.4 % 10.1016/j.bmcl.2008.04.082
None NON-PROTEIN TARGET Inhibition 0.45 % 10.1016/j.bmcl.2014.12.083
None NON-PROTEIN TARGET Potency 1.9 nM None
None NON-PROTEIN TARGET Potency 1882.1 nM None
None NON-PROTEIN TARGET Potency 2983.0 nM None
None NON-PROTEIN TARGET Potency 3346.9 nM None
None NON-PROTEIN TARGET Potency 4727.7 nM None
None NON-PROTEIN TARGET Potency 6678.0 nM None
None NON-PROTEIN TARGET Potency 9432.9 nM None
None NON-PROTEIN TARGET Potency 21671.2 nM None
None NON-PROTEIN TARGET Potency 24315.5 nM None
None NON-PROTEIN TARGET Potency 34346.6 nM None
None NON-PROTEIN TARGET Ratio 0.009 None 10.1021/np960024c
None NON-PROTEIN TARGET Ratio 0.02 None 10.1021/np960024c
None NON-PROTEIN TARGET Ratio 0.05 None 10.1021/np960024c
None NON-PROTEIN TARGET Ratio 0.09 None 10.1021/np960024c
None NON-PROTEIN TARGET Ratio 0.13 None 10.1021/np960024c
None NON-PROTEIN TARGET Ratio 0.19 None 10.1021/np960024c
None NON-PROTEIN TARGET Ratio 1.2 None 10.1021/jm00185a013
None NON-PROTEIN TARGET Ratio IC50/EC50 177.0 None 10.1016/j.ejmech.2016.09.070
None NON-PROTEIN TARGET Ratio IC50/EC50 200.0 None 10.1016/j.ejmech.2016.09.070
None NON-PROTEIN TARGET Ratio IC50/EC50 231.0 None 10.1016/j.ejmech.2016.09.070
None NON-PROTEIN TARGET Ratio IC50/EC50 363.0 None 10.1016/j.ejmech.2016.09.070
None NON-PROTEIN TARGET Relative cytotoxicity 0.4 None 10.1021/jm010126m
None NON-PROTEIN TARGET Relative cytotoxicity 0.6 None 10.1021/jm010126m
None No relevant target Activity 95.9 % 10.1021/acs.jmedchem.9b01963
None No relevant target CLogD 4.5 None 10.1021/jm049949c
None No relevant target Daq 6.2 10'-6cm2/s 10.1021/jm901846t
None No relevant target Fa 18.7 % 10.1039/C9MD00358D
None No relevant target K 7.09 10'-5/s 10.1016/j.bmc.2019.03.017
None No relevant target K 36.0 10'-7/s 10.1016/j.bmc.2019.03.017
None No relevant target LogD 1.39 None 10.1021/jm0000564
None No relevant target LogD 1.52 None 10.1016/j.bmcl.2009.11.039
None No relevant target LogD 1.91 None 10.1021/jm970530e
None No relevant target LogD 2.5 None 10.1021/acs.jmedchem.7b01537
None No relevant target LogD 2.52 None 10.1016/j.ejmech.2021.113630
None No relevant target LogD 2.79 None 10.1016/j.ejmech.2008.11.009
None No relevant target LogD 2.88 None 10.1021/jf102525e
None No relevant target LogD 3.4 None 10.1124/dmd.111.041665
None No relevant target LogD 4.21 None 10.1021/jm011046l
None No relevant target LogD nan None 10.1021/acs.jmedchem.7b01465
None No relevant target LogD7.4 2.61 None 10.6019/CHEMBL3301361
None No relevant target log K -1.27 None 10.1021/jm9003945
None No relevant target log K 1.69 None 10.1021/jm9003945
None No relevant target Log Kmemb 0.9 None 10.1021/jm0309001
None No relevant target LogP 2.51 None 10.1021/jm00179a017
None No relevant target LogP 3.45 None 10.1016/j.bmc.2019.03.017
None No relevant target LogP 3.79 None 10.1016/j.bmc.2007.03.040
None No relevant target LogP 3.79 None 10.1021/jf102525e
None No relevant target LogP 3.79 None 10.1021/jm070524a
None No relevant target LogP 3.79 None 10.1021/jm801441s
None No relevant target LogP 3.79 None 10.1021/jm9003945
None No relevant target LogP 3.795 None 10.1124/dmd.111.042309
None No relevant target LogP 3.8 None 10.1021/jm021012t
None No relevant target LogP 4.23 None 10.1021/jm801441s
None No relevant target LogP 4.33 None 10.1021/jm901846t
None No relevant target LogP 4.55 None 10.1016/j.bmcl.2008.05.034
None No relevant target LogP 5.1 None 10.1016/j.bmc.2008.09.065
None No relevant target LogP 5.52 None 10.1021/jm011046l
None No relevant target LogP 5.69 None 10.1021/jm960384x
None No relevant target LogP nan None 10.1016/j.bmc.2007.09.020
None No relevant target LogP nan None 10.1016/j.ejmech.2010.02.024
None No relevant target logPapp -4.64 None 10.1021/jf102525e
None No relevant target log Pe -5.93 None 10.1021/acs.jmedchem.8b00559
None No relevant target log Pe -3.8 None 10.1016/j.ejmech.2017.01.011
None No relevant target logPeff -4.69 None 10.1016/j.ejmech.2017.01.011
None No relevant target logPeff -4.54 None 10.1016/j.ejmech.2017.01.011
None No relevant target logPeff -4.46 None 10.1016/j.ejmech.2017.01.011
None No relevant target log(permeability) -4.01 None 10.1016/j.ejmech.2018.11.009
None No relevant target Log PNalk 2.27 None 10.1021/jm048980b
None No relevant target Peff 0.59 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 5.43 10'-6 cm/s 10.1039/C9MD00358D
None No relevant target Peff 7.4 10'-6 cm/s 10.1039/C9MD00358D
None No relevant target Peff 10.11 ucm/s 10.1016/j.ejmech.2017.07.008
None No relevant target Peff 11.44 10'-6 cm/s 10.1016/j.bmc.2017.08.048
None No relevant target Peff 14.28 10'-6 cm/s 10.1016/j.ejmech.2017.07.055
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2017.03.070
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2017.05.027
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2017.08.048
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2018.01.030
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2018.02.037
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2018.04.043
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmc.2019.07.001
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmcl.2017.09.057
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmcl.2018.04.043
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.bmcl.2019.126625
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2017.02.039
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2017.07.055
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2018.01.055
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2018.07.056
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2018.11.040
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2018.11.049
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2018.12.013
None No relevant target Peff 16.0 10'-6 cm/s 10.1016/j.ejmech.2019.06.026
None No relevant target Peff 16.0 10'-6 cm/s 10.1021/acs.jmedchem.9b01573
None No relevant target Peff 16.0 ucm/s 10.1016/j.bmc.2017.02.027
None No relevant target Peff 16.0 ucm/s 10.1016/j.bmc.2018.11.015
None No relevant target Peff 16.0 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 16.0 ucm/s 10.1016/j.ejmech.2017.07.008
None No relevant target Peff 16.0 ucm/s 10.1021/acs.jmedchem.7b01356
None No relevant target Peff 16.2 10'-6 cm/s 10.1016/j.bmc.2018.01.030
None No relevant target Peff 16.46 10'-6 cm/s 10.1016/j.ejmech.2018.11.040
None No relevant target Peff 16.9 10'-6 cm/s 10.1016/j.bmc.2018.02.037
None No relevant target Peff 16.9 10'-6 cm/s 10.1016/j.bmcl.2017.09.055
None No relevant target Peff 16.9 10'-6 cm/s 10.1016/j.bmcl.2018.04.043
None No relevant target Peff 16.9 10'-6 cm/s 10.1016/j.bmcl.2019.126625
None No relevant target Peff 16.9 10'-6 cm/s 10.1016/j.ejmech.2019.03.044
None No relevant target Peff 16.9 ucm/s 10.1016/j.bmc.2018.11.015
None No relevant target Peff 17.65 10'-6 cm/s 10.1016/j.ejmech.2017.07.077
None No relevant target Peff 18.5 10'-6 cm/s 10.1021/acs.jmedchem.9b01573
None No relevant target Peff 19.1 10'-6 cm/s 10.1016/j.ejmech.2018.07.056
None No relevant target Peff 19.45 10'-6 cm/s 10.1016/j.ejmech.2018.11.049
None No relevant target Peff 19.8 10'-6 cm/s 10.1016/j.ejmech.2018.01.055
None No relevant target Peff 20.06 10'-6 cm/s 10.1021/acs.jmedchem.0c01129
None No relevant target Peff 20.5 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 21.2 10'-6 cm/s 10.1016/j.ejmech.2018.12.013
None No relevant target Peff 21.3 ucm/s 10.1021/acs.jmedchem.7b01356
None No relevant target Peff 24.4 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 29.0 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 34.9 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 98.0 10'-6 cm/s 10.1016/j.ejmech.2018.11.009
None No relevant target Peff 422.58 nm/s 10.1021/acs.jmedchem.9b01963
None No relevant target Peff 520.0 nm/s 10.1021/acs.jmedchem.8b00286
None No relevant target Peff 2267.0 10'-6 cm/s 10.1016/j.ejmech.2018.12.059
None No relevant target permeability 6.4 ucm/s 10.1016/j.ejmech.2018.01.007
None No relevant target permeability 7.4 ucm/s 10.1016/j.ejmech.2018.01.007
None No relevant target permeability 12.2 % 10.1016/j.bmc.2019.03.017
None No relevant target permeability 13.44 10'-6 cm/s 10.1016/j.bmc.2018.04.043
None No relevant target permeability 14.0 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target permeability 14.5 % 10.1016/j.bmc.2019.03.017
None No relevant target permeability 15.02 ucm/s 10.1039/C8MD00196K
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.bmc.2016.06.045
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.bmc.2019.01.040
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2016.12.009
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2017.02.034
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2017.02.042
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2017.02.045
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2017.06.060
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2018.02.078
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2019.07.051
None No relevant target permeability 16.0 10'-6 cm/s 10.1016/j.ejmech.2019.111737
None No relevant target permeability 16.0 10'-6 cm/s 10.1021/acs.jnatprod.5b00191
None No relevant target permeability 16.0 ucm/s 10.1016/j.bmcl.2017.01.050
None No relevant target permeability 16.0 ucm/s 10.1039/C8MD00196K
None No relevant target permeability 16.2 ucm/s 10.1016/j.bmc.2017.02.027
None No relevant target permeability 16.2 ucm/s 10.1016/j.ejmech.2017.06.020
None No relevant target permeability 16.9 10'-6 cm/s 10.1016/j.bmc.2019.01.040
None No relevant target permeability 16.9 10'-6 cm/s 10.1016/j.ejmech.2016.12.009
None No relevant target permeability 16.9 10'-6 cm/s 10.1016/j.ejmech.2017.02.039
None No relevant target permeability 16.9 10'-6 cm/s 10.1016/j.ejmech.2019.06.026
None No relevant target permeability 16.9 10'-6 cm/s 10.1016/j.ejmech.2019.07.021
None No relevant target permeability 16.9 10'-6 cm/s 10.1016/j.ejmech.2019.111737
None No relevant target permeability 16.9 ucm/s 10.1016/j.bmcl.2017.01.050
None No relevant target permeability 16.9 ucm/s 10.1021/jm500258v
None No relevant target permeability 17.0 ucm/s 10.1016/j.ejmech.2018.01.007
None No relevant target permeability 17.3 10'-6 cm/s 10.1016/j.ejmech.2017.06.060
None No relevant target permeability 18.15 10'-6 cm/s 10.1016/j.ejmech.2017.02.045
None No relevant target permeability 18.2 10'-6 cm/s 10.1016/j.bmc.2017.05.027
None No relevant target permeability 18.5 10'-6 cm/s 10.1021/acs.jnatprod.5b00191
None No relevant target permeability 20.2 10'-6 cm/s 10.1016/j.ejmech.2017.02.034
None No relevant target permeability 22.8 % 10.1016/j.bmc.2019.03.017
None No relevant target permeability 23.7 % 10.1016/j.bmc.2019.03.017
None No relevant target permeability 24.6 ucm/s 10.1021/jm500065f
None No relevant target permeability 26.0 % 10.1016/j.ejmech.2018.12.059
None No relevant target permeability 28.6 10'-6 cm/s 10.1016/j.ejmech.2019.07.051
None No relevant target permeability 53.5 % 10.1016/j.bmc.2019.03.017
None No relevant target permeability 54.0 % 10.1021/acsmedchemlett.8b00473
None No relevant target permeability 73.3 % 10.1016/j.bmc.2019.03.017
None No relevant target permeability 100.0 % 10.1016/j.bmc.2019.03.017
None No relevant target permeability nan None 10.1021/acs.jmedchem.7b01809
None No relevant target pKa 1.36 None 10.1021/jf102525e
None No relevant target pKa 4.18 None 10.1016/j.bmc.2007.03.040
None No relevant target pKa 8.29 None 10.1021/jm011046l
None No relevant target pKa 8.68 None 10.1021/jm020941h
None No relevant target pKa 8.7 None 10.1124/dmd.110.036988
None No relevant target pKa 8.76 None 10.1021/jm901846t
None No relevant target pKa 8.9 None 10.1021/jm0000564
None No relevant target pKa 8.9 None 10.1124/dmd.110.035998
None No relevant target pKa 8.92 None 10.1007/s11095-013-1232-z
None No relevant target pKa 8.92 None 10.1016/j.ejmech.2009.06.004
None No relevant target pKa 8.92 None 10.1021/jm020941h
None No relevant target pKa 8.92 None 10.1021/jm030408h
None No relevant target pKa 8.92 None 10.1021/jm070524a
None No relevant target pKa 8.92 None 10.1021/jm9003945
None No relevant target pKa 9.0 None 10.1124/dmd.111.042309
None No relevant target pKa 9.04 None 10.1021/jm020941h
None No relevant target pKa 9.07 None 10.1007/s11095-013-1232-z
None No relevant target pKa nan None 10.1016/j.bmc.2007.09.020
None No relevant target pKa_B1 8.6 None 10.6019/CHEMBL3301361
None No relevant target Ratio 0.23 10'2No_unit 10.1016/j.bmc.2019.03.017
None No relevant target solubility nan None 10.1016/j.bmc.2015.07.027
None No relevant target solubility nan None 10.1021/jm500853v
None No relevant target Solubility 46.0 ug.mL-1 10.1016/j.bmcl.2015.03.016
None No relevant target Solubility 48.1 ug.mL-1 10.1016/j.bmc.2010.08.003
None No relevant target Solubility 500000.0 nM 10.1016/j.ejmech.2014.02.003
None No relevant target Solubility 500000.0 nM 10.1016/j.ejmech.2015.06.031
None No relevant target Solubility 500000.0 nM 10.1016/j.ejmech.2017.10.048
None No relevant target Solubility 500000.0 nM 10.1016/j.ejmech.2019.04.063
None No relevant target Solubility 500000.0 nM 10.1021/acs.jmedchem.6b00233
None No relevant target Solubility 500000.0 nM 10.1021/acs.jmedchem.7b00392
None Nucleic Acid BPR 95.8 None 10.1124/dmd.111.041145
None Unchecked Ac50 12.59 uM None
None Unchecked Ac50 31.62 uM None
None Unchecked AC50 12589.3 nM None
None Unchecked AC50 31622.8 nM None
None Unchecked Activity 1.6 uM 10.1016/j.ejmech.2018.01.092
None Unchecked Activity 1.6 uM 10.1021/jm8012745
None Unchecked Activity 2.25 % 10.1016/j.ejmech.2018.10.038
None Unchecked Activity 2.4 % 10.1016/j.ejmech.2020.113107
None Unchecked Activity 2.6 nmol/min 10.1016/j.bmc.2008.09.065
None Unchecked Activity 4.0 % 10.1021/np500521v
None Unchecked Activity 4.69 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 6.6 uM/min/uL 10.1016/j.bmcl.2019.126750
None Unchecked Activity 7.0 uM 10.1021/jm070039f
None Unchecked Activity 9.99 % 10.1016/j.ejmech.2018.10.038
None Unchecked Activity 10.0 uM 10.1021/acs.jmedchem.7b01457
None Unchecked Activity 11.1 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 11.44 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 11.57 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 18.47 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 19.0 % 10.1016/j.bmc.2009.04.041
None Unchecked Activity 21.92 % 10.1016/j.ejmech.2018.10.038
None Unchecked Activity 28.0 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 29.0 % 10.1021/np500521v
None Unchecked Activity 31.36 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 40.0 uM 10.1016/j.ejmech.2018.01.027
None Unchecked Activity 46.7 % 10.1016/j.ejmech.2016.05.045
None Unchecked Activity 47.0 % 10.1016/j.bmcl.2016.01.052
None Unchecked Activity 50.0 % 10.1016/j.ejmech.2012.02.034
None Unchecked Activity 50.0 % 10.1021/np960178s
None Unchecked Activity 51.35 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 52.5 % 10.1016/j.ejmech.2018.04.012
None Unchecked Activity 55.1 % 10.1021/np960024c
None Unchecked Activity 57.42 % 10.1016/j.ejmech.2021.113317
None Unchecked Activity 63.0 % 10.1016/j.bmcl.2016.01.052
None Unchecked Activity 65.0 % 10.1016/j.bmc.2007.09.020
None Unchecked Activity 68.09 % 10.1016/j.ejmech.2018.10.038
None Unchecked Activity 73.0 % 10.1016/j.bmcl.2016.01.052
None Unchecked Activity 78.0 % 10.1021/np500521v
None Unchecked Activity 97.0 % 10.1021/np068030o
None Unchecked Activity 99.0 % 10.1016/j.bmcl.2006.09.068
None Unchecked Activity 99.0 % 10.1021/np0604533
None Unchecked Activity 100.0 % 10.1021/np0604533
None Unchecked Activity 103.0 % 10.1016/j.bmcl.2006.09.068
None Unchecked Activity 104.0 % 10.1021/np040219h
None Unchecked Activity 104.0 % 10.1021/np050417o
None Unchecked Activity 106.0 % 10.1021/np050417o
None Unchecked Activity 106.0 % 10.1021/np0600447
None Unchecked Activity 109.0 % 10.1021/np068030o
None Unchecked Activity 114.0 % 10.1021/np0604533
None Unchecked Activity 116.0 % 10.1021/np0600447
None Unchecked Activity 117.0 % 10.1021/np0301083
None Unchecked Activity 140.0 % 10.1016/j.bmcl.2006.09.068
None Unchecked Activity 144.0 % 10.1021/np050417o
None Unchecked Activity 145.0 % 10.1021/np040219h
None Unchecked Activity 145.0 % 10.1021/np0604533
None Unchecked Activity 148.0 % 10.1021/np068030o
None Unchecked Activity 150.0 % 10.1021/np0600447
None Unchecked Activity 160.0 % 10.1016/j.bmcl.2018.02.003
None Unchecked Activity 202.0 % 10.1016/j.ejmech.2020.112331
None Unchecked Activity 207.0 % 10.1021/np0301083
None Unchecked Activity 229.4 % 10.1016/j.ejmech.2012.05.026
None Unchecked Activity 239.0 % 10.1021/np500521v
None Unchecked Activity 254.0 % 10.1016/j.ejmech.2009.04.022
None Unchecked Activity 352.0 % 10.1021/np040219h
None Unchecked Activity 531.0 % 10.1021/np0301083
None Unchecked Activity 179086.0 RLU 10.1021/acs.jmedchem.6b01075
None Unchecked Activity nan None 10.1016/j.bmc.2008.02.012
None Unchecked Activity nan None 10.1016/j.bmc.2013.12.022
None Unchecked Activity nan None 10.1016/j.bmc.2019.06.013
None Unchecked Activity nan None 10.1016/j.bmcl.2010.07.099
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1016/j.ejmech.2013.06.024
None Unchecked Activity nan None 10.1016/j.ejmech.2017.01.020
None Unchecked Activity nan None 10.1016/j.ejmech.2021.113317
None Unchecked Activity nan None 10.1016/j.ejmech.2022.114231
None Unchecked Activity nan None 10.1016/j.ejmech.2022.114822
None Unchecked Activity nan None 10.1021/acs.jmedchem.0c01741
None Unchecked Activity nan None 10.1021/acs.jmedchem.0c02145
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c01452
None Unchecked Activity nan None 10.1021/acs.jmedchem.5b00085
None Unchecked Activity nan None 10.1021/acs.jmedchem.8b01325
None Unchecked Activity nan None 10.1021/jm300378k
None Unchecked Activity nan None 10.1021/jm300564b
None Unchecked Activity nan None 10.1021/jm400930e
None Unchecked Activity nan None 10.1021/jm900194w
None Unchecked Activity nan None 10.1021/np100213a
None Unchecked Activity nan None 10.1021/np960024c
None Unchecked Activity nan None 10.1038/nchembio.79
None Unchecked Activity_index 1.45 None 10.1021/acs.jmedchem.7b00793
None Unchecked Alpha max 0.7 uM 10.1016/j.bmcl.2010.11.059
None Unchecked Alpha max 0.7 uM 10.1021/jm8012745
None Unchecked Alpha max 0.7 None 10.1016/j.bmc.2017.11.016
None Unchecked Alpha max 0.7 None 10.1016/j.ejmech.2014.09.084
None Unchecked Alpha max 0.7 None 10.1016/j.ejmech.2017.01.019
None Unchecked Alpha max 0.7 None 10.1016/j.ejmech.2018.01.092
None Unchecked Anticonvulsant activity nan None 10.1016/s0960-894x(03)00535-3
None Unchecked APDc 47.73 None 10.6019/CHEMBL4295262
None Unchecked APDc 56.06 None 10.6019/CHEMBL4295262
None Unchecked APDc 58.06 None 10.6019/CHEMBL4295262
None Unchecked APDc 65.11 None 10.6019/CHEMBL4295262
None Unchecked Control 254.0 % 10.1016/S0960-894X(97)00029-2
None Unchecked Control 254.0 % 10.1016/s0960-894x(99)00009-8
None Unchecked Control 739.0 % 10.1016/S0960-894X(97)00029-2
None Unchecked Control 739.0 % 10.1016/s0960-894x(99)00009-8
None Unchecked EC50 245.0 nM 10.1016/j.ejmech.2016.09.070
None Unchecked EC50 245.0 nM 10.1021/jm201121b
None Unchecked EC50 245.1 nM 10.1016/j.ejmech.2018.01.027
None Unchecked EC50 254.4 nM 10.1016/j.ejmech.2021.113795
None Unchecked EC50 350.0 nM 10.1016/j.ejmech.2016.09.070
None Unchecked EC50 385.0 nM 10.1016/j.ejmech.2016.09.070
None Unchecked EC50 385.0 nM 10.1016/j.ejmech.2021.113795
None Unchecked EC50 385.0 nM 10.1021/jm201121b
None Unchecked EC50 428.0 nM 10.1021/jm201121b
None Unchecked EC50 445.7 nM 10.1016/j.ejmech.2021.113795
None Unchecked EC50 446.0 nM 10.1016/j.ejmech.2016.09.070
None Unchecked EC50 502.5 nM 10.1016/j.ejmech.2021.113795
None Unchecked EC50 503.0 nM 10.1016/j.ejmech.2016.09.070
None Unchecked EC50 503.0 nM 10.1021/jm201121b
None Unchecked EC50 700.0 nM 10.1016/j.bmc.2016.12.034
None Unchecked EC50 800.0 nM 10.1016/j.bmc.2016.12.034
None Unchecked EC50 900.0 nM 10.1016/j.bmc.2016.12.034
None Unchecked EC50 1000.0 nM 10.1016/j.bmc.2016.12.034
None Unchecked EC50 3100.0 nM 10.1021/jm010126m
None Unchecked EC50 4100.0 nM 10.1021/jm010126m
None Unchecked EC50 7100.0 nM 10.1016/j.bmc.2014.09.023
None Unchecked EC50 20000.0 nM 10.1016/j.bmc.2008.01.055
None Unchecked EC50 20540.0 nM 10.1016/j.ejmech.2018.04.012
None Unchecked EC50 nan None 10.1021/jm201121b
None Unchecked FC 0.96 None 10.1016/j.bmcl.2011.07.077
None Unchecked FC 1.01 None 10.1016/j.ejmech.2018.01.027
None Unchecked FC 1.08 None 10.1021/acs.jmedchem.0c01741
None Unchecked FC 1.13 None 10.1016/j.ejmech.2018.01.027
None Unchecked FC 1.18 None 10.1021/acs.jmedchem.0c01741
None Unchecked FC 1.19 None 10.1021/acs.jmedchem.0c01741
None Unchecked FC 1.27 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 1.33 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 1.59 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 1.61 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 1.7 None 10.1016/j.bmc.2010.02.046
None Unchecked FC 1.8 None 10.1016/j.ejmech.2020.112555
None Unchecked FC 1.82 None 10.1016/j.ejmech.2018.01.019
None Unchecked FC 1.85 None 10.1016/j.ejmech.2018.01.027
None Unchecked FC 1.9 None 10.1016/j.bmc.2016.03.065
None Unchecked FC 1.98 None 10.1016/j.ejmech.2015.10.054
None Unchecked FC 2.0 None 10.1016/j.ejmech.2013.06.024
None Unchecked FC 2.0 None 10.1016/j.ejmech.2017.09.014
None Unchecked FC 2.06 None 10.1016/j.ejmech.2018.01.027
None Unchecked FC 2.1 None 10.1016/j.ejmech.2016.05.045
None Unchecked FC 2.11 None 10.1016/j.ejmech.2018.01.027
None Unchecked FC 2.2 None 10.1016/j.ejmech.2015.10.054
None Unchecked FC 2.3 None 10.1016/j.ejmech.2016.09.070
None Unchecked FC 2.6 None 10.1021/acs.jmedchem.6b01787
None Unchecked FC 2.7 None 10.1016/j.ejmech.2016.09.070
None Unchecked FC 2.82 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 3.0 None 10.1016/j.bmc.2015.07.027
None Unchecked FC 3.0 None 10.1021/acs.jmedchem.1c01452
None Unchecked FC 3.3 None 10.1016/j.ejmech.2012.05.026
None Unchecked FC 3.6 None 10.1016/j.ejmech.2018.04.012
None Unchecked FC 3.9 None 10.1016/j.bmc.2010.02.046
None Unchecked FC 3.91 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 4.0 None 10.1016/j.ejmech.2013.06.024
None Unchecked FC 4.0 None 10.1016/j.ejmech.2016.09.070
None Unchecked FC 4.0 None 10.1016/j.ejmech.2017.09.014
None Unchecked FC 4.0 None 10.1016/j.ejmech.2021.113795
None Unchecked FC 4.0 None 10.1021/acs.jnatprod.0c00334
None Unchecked FC 4.2 None 10.1021/acs.jmedchem.6b01787
None Unchecked FC 4.34 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 4.5 None 10.1016/j.bmc.2016.03.065
None Unchecked FC 5.0 None 10.1021/acs.jmedchem.6b01050
None Unchecked FC 5.13 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 5.32 None 10.1016/j.bmc.2010.07.055
None Unchecked FC 5.4 None 10.1016/j.bmc.2016.12.034
None Unchecked FC 5.4 None 10.1021/acs.jnatprod.6b01005
None Unchecked FC 5.5 None 10.1016/j.bmc.2016.12.034
None Unchecked FC 5.6 None 10.1016/j.ejmech.2021.113317
None Unchecked FC 6.0 None 10.1021/acs.jnatprod.0c00334
None Unchecked FC 6.69 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 7.15 None 10.1016/j.ejmech.2018.01.019
None Unchecked FC 7.8 None 10.1021/acs.jmedchem.1c01452
None Unchecked FC 8.0 None 10.1016/j.bmc.2015.07.027
None Unchecked FC 8.0 None 10.1016/j.ejmech.2017.09.014
None Unchecked FC 8.1 None 10.1016/j.bmc.2012.02.050
None Unchecked FC 8.5 None 10.1016/j.ejmech.2018.07.053
None Unchecked FC 8.85 None 10.1016/j.bmc.2010.07.055
None Unchecked FC 9.0 None 10.1021/jm300378k
None Unchecked FC 9.1 None 10.1021/acs.jnatprod.8b00362
None Unchecked FC 9.2 None 10.1021/acs.jnatprod.1c00519
None Unchecked FC 10.35 None 10.1016/j.ejmech.2018.01.027
None Unchecked FC 16.0 None 10.1016/j.ejmech.2017.09.014
None Unchecked FC 16.0 None 10.1016/j.ejmech.2021.113317
None Unchecked FC 17.45 None 10.1016/j.bmcl.2011.07.077
None Unchecked FC 20.4 None 10.1016/j.ejmech.2016.05.045
None Unchecked FC 22.91 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 24.03 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 29.79 None 10.1016/j.ejmech.2017.11.081
None Unchecked FC 29.9 None 10.1016/j.bmc.2010.02.046
None Unchecked FC 31.0 None 10.1021/jm300378k
None Unchecked FC 40.0 None 10.1016/j.ejmech.2021.113317
None Unchecked FC 46.13 None 10.1016/j.ejmech.2016.08.044
None Unchecked FC 54.4 None 10.1016/j.bmc.2016.12.034
None Unchecked FC 55.3 None 10.1016/j.bmc.2016.12.034
None Unchecked FC 55.4 None 10.1016/j.bmc.2016.12.034
None Unchecked FC 60.0 None 10.1016/j.bmcl.2012.03.037
None Unchecked FC 64.0 None 10.1016/j.ejmech.2017.09.014
None Unchecked FC 64.5 None 10.1021/acs.jnatprod.6b00190
None Unchecked FC 80.7 None 10.1016/j.bmc.2016.12.034
None Unchecked FC 109.0 None 10.1021/jm300378k
None Unchecked FC 141.2 None 10.1021/jm101249z
None Unchecked FC 259.46 None 10.1021/acs.jnatprod.6b01099
None Unchecked Flu intensity 0.56 None 10.1021/acs.jmedchem.6b00525
None Unchecked Flu intensity 1.0 None 10.1016/j.ejmech.2018.01.092
None Unchecked Flu intensity 2.3 None 10.1016/j.ejmech.2018.01.092
None Unchecked Flu intensity 3.9 None 10.1021/acs.jmedchem.6b00525
None Unchecked Flu intensity 229.5 None 10.1016/j.bmcl.2012.09.096
None Unchecked FPDc 0.02679 None 10.6019/CHEMBL4295262
None Unchecked FPDc 0.03865 None 10.6019/CHEMBL4295262
None Unchecked FPDc 48.96 None 10.6019/CHEMBL4295262
None Unchecked FPDc 50.52 None 10.6019/CHEMBL4295262
None Unchecked FPDc 54.23 None 10.6019/CHEMBL4295262
None Unchecked FPDc 56.48 None 10.6019/CHEMBL4295262
None Unchecked FPDc nan None 10.6019/CHEMBL4295262
None Unchecked FPD measurement 0.02679 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 0.03865 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 47.73 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 52.61 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 56.06 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 58.06 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 58.45 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 65.11 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement nan None 10.6019/CHEMBL4295262
None Unchecked GI 50.0 % 10.1016/j.bmc.2017.08.003
None Unchecked HC50 861.0 uM 10.1021/jm011046l
None Unchecked Hepatotoxicity (acute) 10.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked I0.5 1.6 uM 10.1016/j.ejmech.2017.01.019
None Unchecked IC50 1.31 nM 10.1016/j.bmcl.2018.11.023
None Unchecked IC50 1.593 nM 10.1016/j.ejmech.2020.112555
None Unchecked IC50 1.62 nM 10.1021/acs.jmedchem.0c01741
None Unchecked IC50 3.84 nM 10.1021/acs.jmedchem.0c01741
None Unchecked IC50 4.52 nM 10.1016/j.ejmech.2022.114207
None Unchecked IC50 10.87 nM 10.1016/j.ejmech.2022.114207
None Unchecked IC50 14.0 nM None
None Unchecked IC50 18.8 nM 10.1016/j.ejmech.2020.112555
None Unchecked IC50 20.31 nM 10.1016/j.ejmech.2021.113317
None Unchecked IC50 22.85 nM 10.1016/j.ejmech.2022.114207
None Unchecked IC50 27.36 nM 10.1016/j.ejmech.2021.113317
None Unchecked IC50 32.9 nM 10.1016/j.bmc.2018.04.038
None Unchecked IC50 35.1 nM 10.1016/j.ejmech.2016.09.070
None Unchecked IC50 38.0 nM 10.1016/j.ejmech.2021.113795
None Unchecked IC50 38.0 nM 10.1021/jm00062a015
None Unchecked IC50 38.0 nM 10.1021/jm00084a002
None Unchecked IC50 40.11 nM 10.1016/j.bmcl.2018.11.023
None Unchecked IC50 47.0 nM None
None Unchecked IC50 60.2 nM 10.1021/jm801589x
None Unchecked IC50 100.0 nM 10.1021/np0605889
None Unchecked IC50 158.04 nM 10.1016/j.ejmech.2022.114207
None Unchecked IC50 200.0 nM 10.1016/j.ejmech.2016.01.034
None Unchecked IC50 204.43 nM 10.1021/acs.jmedchem.1c00246
None Unchecked IC50 300.0 nM 10.1016/j.bmc.2014.09.023
None Unchecked IC50 300.0 nM 10.1021/acs.jmedchem.1c01452
None Unchecked IC50 330.0 nM 10.1016/j.bmcl.2016.01.052
None Unchecked IC50 366.7 ug.mL-1 10.1016/j.bmc.2009.04.041
None Unchecked IC50 900.0 nM 10.1021/np3000987
None Unchecked IC50 1600.0 nM 10.1016/j.bmc.2017.11.016
None Unchecked IC50 1600.0 nM 10.1016/j.bmcl.2010.11.059
None Unchecked IC50 1600.0 nM 10.1016/j.ejmech.2014.09.084
None Unchecked IC50 2005.0 nM None
None Unchecked IC50 2100.0 nM 10.1021/acs.jnatprod.2c01033
None Unchecked IC50 2500.0 nM 10.1021/jm000155h
None Unchecked IC50 2824.0 nM None
None Unchecked IC50 5400.0 nM 10.1016/j.bmc.2010.12.043
None Unchecked IC50 5524.0 nM None
None Unchecked IC50 6500.0 nM 10.1021/jm00109a010
None Unchecked IC50 6590.0 nM 10.1021/acs.jnatprod.6b01005
None Unchecked IC50 6610.0 nM 10.1021/acs.jnatprod.1c00519
None Unchecked IC50 6800.0 nM 10.1016/j.bmc.2014.10.032
None Unchecked IC50 7084.0 nM 10.1016/j.bmc.2019.06.013
None Unchecked IC50 7110.0 nM 10.1021/acs.jmedchem.0c01741
None Unchecked IC50 8500.0 nM 10.1016/j.bmc.2016.03.065
None Unchecked IC50 9600.0 nM 10.1016/j.bmc.2014.10.032
None Unchecked IC50 10000.0 nM 10.1021/acs.jnatprod.5b01117
None Unchecked IC50 12920.0 nM 10.1016/j.ejmech.2012.02.034
None Unchecked IC50 13000.0 nM 10.1039/C7MD00424A
None Unchecked IC50 15000.0 nM 10.1021/acs.jmedchem.9b00062
None Unchecked IC50 15920.0 nM 10.1016/j.bmc.2014.10.032
None Unchecked IC50 18200.0 nM 10.1016/j.ejmech.2020.112331
None Unchecked IC50 19840.0 nM 10.1016/j.bmc.2016.03.065
None Unchecked IC50 20600.0 nM 10.1021/acs.jmedchem.1c01452
None Unchecked IC50 26060.0 nM 10.1016/j.ejmech.2012.02.034
None Unchecked IC50 26240.0 nM 10.1016/j.bmc.2019.06.013
None Unchecked IC50 27180.0 nM 10.1021/acs.jmedchem.6b00605
None Unchecked IC50 30000.0 nM 10.1016/j.bmc.2018.03.045
None Unchecked IC50 30000.0 nM 10.1021/acs.jnatprod.6b01005
None Unchecked IC50 40110.0 nM 10.1016/j.ejmech.2020.112555
None Unchecked IC50 40800.0 nM 10.1016/j.bmc.2014.10.032
None Unchecked IC50 50000.0 nM 10.1016/j.bmc.2019.06.013
None Unchecked IC50 50000.0 nM 10.1016/j.ejmech.2016.08.044
None Unchecked IC50 50000.0 nM 10.1016/j.ejmech.2020.112422
None Unchecked IC50 51050.0 nM 10.1016/j.ejmech.2012.02.034
None Unchecked IC50 51400.0 nM 10.1016/j.ejmech.2012.02.034
None Unchecked IC50 56600.0 nM 10.1021/np300375t
None Unchecked IC50 80000.0 nM 10.1016/j.bmc.2014.10.032
None Unchecked IC50 80000.0 nM 10.1016/j.bmc.2018.03.045
None Unchecked IC50 100000.0 nM 10.1016/j.ejmech.2018.01.027
None Unchecked IC50 nan None 10.1016/j.bmc.2019.06.013
None Unchecked IC50 nan None 10.1016/j.ejmech.2022.114231
None Unchecked IC50 nan None None
None Unchecked Inhibition 10.0 % 10.1016/j.ejmech.2017.06.047
None Unchecked Inhibition 15.0 % 10.1021/jm000083u
None Unchecked Inhibition 19.0 % 10.1021/jm000083u
None Unchecked Inhibition 22.3 % 10.1016/j.bmcl.2012.01.107
None Unchecked Inhibition 50.0 % 10.1016/j.ejmech.2016.03.083
None Unchecked Inhibition 50.0 % 10.1021/jm500109z
None Unchecked Inhibition 95.0 % 10.1016/j.bmc.2018.04.038
None Unchecked Inhibition 100.0 % 10.1021/jm801589x
None Unchecked Inhibition nan % 10.1007/s00044-012-0203-y
None Unchecked Inhibition nan % 10.1016/j.bmc.2012.02.050
None Unchecked Inhibition nan % 10.1016/j.bmc.2012.05.065
None Unchecked Inhibition nan % 10.1016/j.bmc.2013.04.034
None Unchecked Inhibition nan % 10.1016/j.bmc.2014.10.032
None Unchecked Inhibition nan % 10.1016/j.bmc.2016.11.023
None Unchecked Inhibition nan % 10.1016/j.bmc.2018.03.045
None Unchecked Inhibition nan % 10.1016/j.bmc.2018.04.038
None Unchecked Inhibition nan % 10.1016/j.bmc.2019.06.013
None Unchecked Inhibition nan % 10.1016/j.bmcl.2012.01.107
None Unchecked Inhibition nan % 10.1016/j.bmcl.2012.03.005
None Unchecked Inhibition nan % 10.1016/j.bmcl.2018.05.059
None Unchecked Inhibition nan % 10.1016/j.ejmech.2017.01.020
None Unchecked Inhibition nan % 10.1016/j.ejmech.2018.01.027
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.112331
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.112555
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.0c01741
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b00031
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b01075
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b01787
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.8b00362
None Unchecked Inhibition nan % 10.1021/np100429s
None Unchecked Inhibition nan % 10.1021/np900792p
None Unchecked K 0.0085 /s 10.1016/j.bmc.2016.03.065
None Unchecked Kd 2400.0 nM 10.1016/j.bmc.2013.12.022
None Unchecked Ki 12.0 nM None
None Unchecked Ki 45.0 nM None
None Unchecked Ki 1738.0 nM None
None Unchecked Ki 1830.0 nM None
None Unchecked Ki 2880.0 nM 10.1016/j.ejmech.2018.01.027
None Unchecked Ki 2920.0 nM 10.1016/j.ejmech.2018.01.027
None Unchecked Ki 3683.0 nM None
None Unchecked Ki nan None None
None Unchecked Km 700.0 nM 10.1016/j.bmc.2008.02.029
None Unchecked Km 890.0 nM 10.1016/j.bmc.2008.02.029
None Unchecked logIC50 0.52 None 10.1016/j.bmc.2013.11.049
None Unchecked MED 1.0 uM 10.1016/j.ejmech.2020.112331
None Unchecked MIC 0.0625 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 1.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 2.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 3.125 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 4.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 6.25 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 8.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 12.5 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 16.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 25.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 32.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 50.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 64.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 128.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 256.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked MIC 512.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
None Unchecked Modulation factor 7.0 None 10.1021/jm981064b
None Unchecked Modulation factor 31.0 None 10.1021/jm981064b
None Unchecked Potency 2093.1 nM None
None Unchecked Potency 9349.5 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 14575.0 nM None
None Unchecked Potency 15848.9 nM None
None Unchecked Potency 16626.1 nM None
None Unchecked Potency 18356.4 nM None
None Unchecked Potency 20931.0 nM None
None Unchecked Potency 23485.0 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency 37221.2 nM None
None Unchecked Potency 41762.9 nM None
None Unchecked Potency 46858.7 nM None
None Unchecked Ratio 0.67 None 10.1021/acs.jmedchem.1c00246
None Unchecked Ratio 0.73 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 1.07 None 10.1016/j.ejmech.2020.112555
None Unchecked Ratio 1.2 None 10.1021/acs.jmedchem.6b00525
None Unchecked Ratio 1.33 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 1.35 None 10.1016/j.ejmech.2022.114207
None Unchecked Ratio 1.46 None 10.1016/j.bmcl.2015.05.018
None Unchecked Ratio 1.51 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 1.59 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 1.61 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 1.9 None 10.1021/jm501676v
None Unchecked Ratio 2.0 None 10.1021/jm201121b
None Unchecked Ratio 2.05 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 2.1 None 10.1021/jm800480y
None Unchecked Ratio 2.2 None 10.1021/acs.jmedchem.6b00525
None Unchecked Ratio 2.24 None 10.1016/j.ejmech.2015.01.006
None Unchecked Ratio 2.25 None 10.1021/acs.jnatprod.6b01099
None Unchecked Ratio 2.31 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 2.41 None 10.1016/j.ejmech.2017.09.014
None Unchecked Ratio 2.87 None 10.1016/j.ejmech.2015.01.006
None Unchecked Ratio 3.0 None 10.1021/jm00169a011
None Unchecked Ratio 3.1 None 10.1021/jm000282d
None Unchecked Ratio 3.46 None 10.1016/j.ejmech.2015.01.006
None Unchecked Ratio 3.5 None 10.1021/jm201121b
None Unchecked Ratio 4.0 None 10.1016/j.bmc.2010.06.004
None Unchecked Ratio 4.1 None 10.1021/jm800480y
None Unchecked Ratio 4.4 None 10.1016/j.ejmech.2022.114207
None Unchecked Ratio 4.98 None 10.1016/j.bmcl.2015.05.018
None Unchecked Ratio 5.1 None 10.1016/j.bmc.2010.06.004
None Unchecked Ratio 5.54 None 10.1039/C7MD00178A
None Unchecked Ratio 9.66 None 10.1016/j.bmc.2020.115798
None Unchecked Ratio 17.7 None 10.1021/jm00169a011
None Unchecked Ratio 32.0 None 10.1021/jm00185a013
None Unchecked Ratio 52.48 None 10.1016/j.ejmech.2022.114207
None Unchecked Ratio 141.87 None 10.1016/j.ejmech.2022.114207
None Unchecked Ratio 211.0 None 10.1016/j.ejmech.2020.112555
None Unchecked Ratio 418.0 None 10.1016/j.ejmech.2020.112555
None Unchecked Ratio CC50/IC50 21.0 None 10.1039/C7MD00424A
None Unchecked Ratio EC50 7.1 None 10.1021/acs.jmedchem.5b00058
None Unchecked Ratio ED50 3.0 None 10.1021/np960024c
None Unchecked Ratio ED50 6.0 None 10.1021/np960024c
None Unchecked Ratio ED50 10.0 None 10.1021/np9702042
None Unchecked Ratio ED50 18.0 None 10.1021/np960024c
None Unchecked Ratio ED50 26.0 None 10.1021/np960024c
None Unchecked Ratio ED50 30.0 None 10.1021/np9702042
None Unchecked Ratio ED50 32.0 None 10.1021/np960024c
None Unchecked Ratio ED50 50.0 None 10.1021/np960024c
None Unchecked Ratio ED50 50.0 None 10.1021/np9702042
None Unchecked Ratio ED50 70.0 None 10.1021/np9702042
None Unchecked Ratio ED50 75.0 None 10.1021/np9702042
None Unchecked Ratio IC50 0.27 None 10.1016/j.bmcl.2016.01.052
None Unchecked Ratio IC50 0.37 None 10.1016/j.bmcl.2016.01.052
None Unchecked Ratio IC50 0.53 None 10.1016/j.bmcl.2016.01.052
None Unchecked Ratio IC50 0.6 None 10.1021/jm8012745
None Unchecked Ratio IC50 0.7 None 10.1021/jm8012745
None Unchecked Ratio IC50 1.07 None 10.1016/j.bmcl.2018.11.023
None Unchecked Ratio IC50 1.7 None 10.1021/jm8012745
None Unchecked Ratio IC50 1.9 None 10.1016/j.bmc.2014.10.032
None Unchecked Ratio IC50 2.11 None 10.1016/j.bmc.2019.06.013
None Unchecked Ratio IC50 2.31 None 10.1016/j.bmcl.2017.09.009
None Unchecked Ratio IC50 2.65 None 10.1016/j.bmcl.2017.09.009
None Unchecked Ratio IC50 2.82 None 10.1016/j.bmcl.2009.05.103
None Unchecked Ratio IC50 2.95 None 10.1016/j.bmc.2009.04.041
None Unchecked Ratio IC50 3.0 None 10.1016/j.ejmech.2017.01.019
None Unchecked Ratio IC50 3.0 None 10.1016/j.ejmech.2018.01.092
None Unchecked Ratio IC50 3.3 None 10.1016/j.bmc.2018.03.045
None Unchecked Ratio IC50 3.4 None 10.1016/j.bmc.2014.10.032
None Unchecked Ratio IC50 3.4 None 10.1021/jm8012745
None Unchecked Ratio IC50 3.54 None 10.1016/j.bmcl.2017.09.009
None Unchecked Ratio IC50 4.2 None 10.1021/jm8012745
None Unchecked Ratio IC50 4.4 None 10.1021/np070458f
None Unchecked Ratio IC50 4.8 None 10.1016/j.bmc.2018.03.045
None Unchecked Ratio IC50 5.0 None 10.1021/np070458f
None Unchecked Ratio IC50 5.7 None 10.1021/np070458f
None Unchecked Ratio IC50 6.74 None 10.1016/j.bmcl.2009.05.103
None Unchecked Ratio IC50 7.1 None 10.1021/acs.jnatprod.1c00821
None Unchecked Ratio IC50 7.6 None 10.1021/np9804379
None Unchecked Ratio IC50 7.8 None 10.1021/np070458f
None Unchecked Ratio IC50 7.83 None 10.1016/j.bmc.2019.06.013
None Unchecked Ratio IC50 8.1 None 10.1021/acs.jnatprod.1c00821
None Unchecked Ratio IC50 8.4 None 10.1016/j.bmc.2014.10.032
None Unchecked Ratio IC50 8.7 None 10.1016/j.bmc.2014.10.032
None Unchecked Ratio IC50 9.7 None 10.1021/np9804379
None Unchecked Ratio IC50 10.71 None 10.1016/j.bmcl.2009.05.103
None Unchecked Ratio IC50 11.2 None 10.1021/acs.jnatprod.2c01033
None Unchecked Ratio IC50 15.0 None 10.1039/C7MD00424A
None Unchecked Ratio IC50 20.0 None 10.1021/np9804379
None Unchecked Ratio IC50 22.2 None 10.1021/np980479x
None Unchecked Ratio IC50 24.5 None 10.1021/np9804379
None Unchecked Ratio IC50 28.5 None 10.1016/j.bmcl.2014.12.083
None Unchecked Ratio IC50 29.98 None 10.1016/j.ejmech.2022.114300
None Unchecked Ratio IC50 509.0 None 10.1016/j.bmcl.2018.11.023
None Unchecked Ratio IC50 nan None 10.1016/j.bmcl.2016.01.052
None Unchecked Ratio IC50 nan None 10.1016/j.ejmech.2022.114231
None Unchecked Ratio IC50/EC50 46.0 None 10.1021/acs.jmedchem.8b00834
None Unchecked Ratio IC50/EC50 200.0 None 10.1016/j.bmc.2015.07.027
None Unchecked Ratio IC50/EC50 200.0 None 10.1021/acs.jmedchem.5b00085
None Unchecked RBA 1.11 None 10.1016/j.bmc.2010.05.003
None Unchecked RBA 2.01 None 10.1016/j.bmc.2010.05.003
None Unchecked RBA 2.8 None 10.1016/j.bmc.2010.05.003
None Unchecked Relative activity 100.0 None 10.1016/s0960-894x(99)00620-4
None Unchecked Relative potency 6.8 None 10.1021/jm010126m
None Unchecked Relative potency 10.2 None 10.1021/jm010126m
None Unchecked RFU 0.27 None 10.1016/j.bmcl.2021.128088
None Unchecked RFU 0.39 None 10.1016/j.bmcl.2021.128088
None Unchecked RFU 2.21 None 10.1021/acs.jmedchem.5b00428
None Unchecked RI 0.7 None 10.1021/jm0303204
None Unchecked RI 0.8 None 10.1021/jm0303204
None Unchecked RI 0.9 None 10.1021/jm0303204
None Unchecked RI 1.0 None 10.1021/jm0303204
None Unchecked RI 1.1 None 10.1021/jm0303204
None Unchecked RI 1.2 None 10.1021/jm0303204
None Unchecked RI 1.6 None 10.1021/jm0303204
None Unchecked RI 2.0 None 10.1021/jm0303204
None Unchecked RI 2.4 None 10.1021/jm0303204
None Unchecked RI 2.7 None 10.1021/jm0303204
None Unchecked RI 3.7 None 10.1021/jm0303204
None Unchecked RI 4.6 None 10.1021/jm0303204
None Unchecked RI 15.0 None 10.1021/jm0303204
None Unchecked RI 50.0 None 10.1021/jm0303204
None Unchecked RI 61.0 None 10.1021/jm0303204
None Unchecked RI 106.0 None 10.1021/jm0303204
None Unchecked RI 112.0 None 10.1021/jm0303204
None Unchecked RI 173.0 None 10.1021/jm0303204
None Unchecked RI 330.0 None 10.1021/jm0303204
None Unchecked RI 1000.0 None 10.1021/jm0303204
None Unchecked RLU 231282.0 None 10.1016/j.bmc.2012.02.050
None Unchecked RLU 231282.0 None 10.1016/j.ejmech.2012.02.034
None Unchecked Selectivity Index nan None 10.1021/jm500853v
None Unchecked Survival 34.91 % 10.1016/j.ejmech.2022.114207
None Unchecked Survival 75.58 % 10.1016/j.bmcl.2018.11.023
None Unchecked Survival 81.85 % 10.1016/j.bmcl.2018.11.023
None Unchecked Survival 82.82 % 10.1016/j.bmcl.2018.11.023
None Unchecked Survival 113.84 % 10.1016/j.bmcl.2018.11.023
None Unchecked Survival nan None 10.1016/j.ejmech.2018.10.038
None Unchecked TGI nan None 10.1021/acs.jmedchem.0c01741
None Unchecked VCR accumulation 285.0 None 10.1016/s0960-894x(98)00262-5
None Unchecked VCR accumulation 666.0 None 10.1016/s0960-894x(98)00262-5
None Unchecked Vmax 22.39 uM 10.1016/j.bmc.2008.02.029
None Unchecked Vmax 36.93 uM 10.1016/j.bmc.2008.02.029

Metabolism Information