Clausamine B
AlkaPlorer ID: AK322364
Synonym: None
IUPAC Name: 6-methoxy-2-prop-1-en-2-yl-2,7-dihydro-1H-pyrano[3,4-c]carbazol-4-one
Structure
SMILES: C=C(C)C1CC2=C(C=C(OC)C3=C2C2=CC=CC=C2N3)C(=O)O1
InChI: InChI=1S/C19H17NO3/c1-10(2)15-8-12-13(19(21)23-15)9-16(22-3)18-17(12)11-6-4-5-7-14(11)20-18/h4-7,9,15,20H,1,8H2,2-3H3
InChIKey: JUASZGNNULZOET-UHFFFAOYSA-N
Reference
γ-Lactone Carbazoles from <i>Clausena anisata</i>
PubChem CID: 10662509
CAS: 205116-60-5
LOTUS: LTS0123163
NPASS: NPC474688
COCONUT: CNP0127584.1
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Clausena anisata | Clausena | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 307.34900000000005
TPSA？: 51.32000000000001
MolLogP？: 3.987300000000002
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | HL-60 | Activity | 80.3 | % | 10.1021/np800735m |
| Homo sapiens | Raji | Activity | 60.0 | % | 10.1021/np990285x |
| Homo sapiens | Raji | Activity | 70.0 | % | 10.1021/np990285x |
| Homo sapiens | Raji | Activity | 80.0 | % | 10.1021/np990285x |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 0.25 | ug.mL-1 | 10.1016/j.bmc.2019.07.023 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 8.0 | ug.mL-1 | 10.1016/j.bmc.2019.07.023 |
| None | Unchecked | Activity | 18.3 | % | 10.1021/np990285x |
| None | Unchecked | Activity | 39.2 | % | 10.1021/np990285x |
| None | Unchecked | Activity | 78.2 | % | 10.1021/np990285x |
| None | Unchecked | Activity | 100.0 | % | 10.1021/np990285x |