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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK322683

Synonym: None

IUPAC Name: 2-[(1S,2S,3R,4S,5S,6R)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine

Structure

SMILES: CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O)O[C@@H](CO)[C@H](O)[C@H]1O

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InChI: InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+/m0/s1

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InChIKey: UCSJYZPVAKXKNQ-ZCTIVXDHSA-N

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Reference

PubChem CID: 6602485

NPASS: NPC478574

Source

Species Genus Family Order Class Phylum Kingdom Domain
Halichondria panicea Halichondria Halichondriidae Suberitida Demospongiae Porifera Metazoa Eukaryota

Properties Information

Molecule Weight: 581.5800000000004

TPSA？: 331.43000000000006

MolLogP？: -7.741760000000005

Number of H-Donors: 14

Number of H-Acceptors: 15

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 2000.0 nM 10.1021/acs.jmedchem.1c00614
Acinetobacter baumannii Acinetobacter baumannii MIC 128000.0 nM 10.1021/acs.jmedchem.1c02122
Bacillus anthracis Bacillus anthracis MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.0c01309
Bacillus cereus Bacillus cereus IZ 16.0 mm 10.1039/d2md00076h
Bacillus cereus Bacillus cereus MBC 8.6 10'-2mmol/ml 10.1039/C8MD00076J
Bacillus cereus Bacillus cereus MBC99.5 8.6 10'-2microM 10.1016/j.bmc.2018.08.004
Bacillus cereus Bacillus cereus MBC99.5 8.6 10'-2 umol/ml 10.1039/C7MD00334J
Bacillus cereus Bacillus cereus MIC 4.3 10'-2mmol/ml 10.1039/C8MD00076J
Bacillus cereus Bacillus cereus MIC 4.3 10'-2 umol/ml 10.1039/C7MD00334J
Bacillus cereus Bacillus cereus MIC 43.0 nM 10.1016/j.bmc.2018.08.004
Bacillus subtilis Bacillus subtilis IZ 10.0 mm 10.1016/j.bmcl.2021.128381
Bacillus subtilis Bacillus subtilis IZ 16.0 mm 10.1016/j.bmcl.2018.09.021
Bacillus subtilis Bacillus subtilis IZ 16.2 mm 10.1039/d2md00192f
Bacillus subtilis Bacillus subtilis IZ 18.0 mm 10.1039/d2md00076h
Bacillus subtilis Bacillus subtilis IZ 20.0 mm 10.1016/j.bmcl.2021.128381
Bacillus subtilis Bacillus subtilis IZ 25.0 mm 10.1016/j.bmcl.2016.07.036
Bacillus subtilis Bacillus subtilis MBC 2.1 umol/L 10.1016/j.bmcl.2016.07.020
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Bacillus subtilis Bacillus subtilis MIC 2.9 ug.mL-1 10.1021/acs.jnatprod.5b00641
Bacillus subtilis Bacillus subtilis MIC 5.0 ug.mL-1 10.1021/acs.jnatprod.5b00436
Bacillus subtilis Bacillus subtilis MIC 5.0 ug.mL-1 10.1039/d2md00192f
Bacillus subtilis Bacillus subtilis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2020.112278
Bacillus subtilis Bacillus subtilis MIC 17.25 ug.mL-1 10.1016/j.ejmech.2018.11.025
Bacillus subtilis Bacillus subtilis MIC 25.0 ug 10.1016/j.bmcl.2018.09.021
Bacillus subtilis Bacillus subtilis MIC 2000.0 nM 10.1021/acs.jmedchem.1c00614
Bacillus subtilis Bacillus subtilis MIC 2200.0 ug.mL-1 10.1016/j.ejmech.2021.113921
Bacillus subtilis Bacillus subtilis MIC 25000.0 nM 10.1016/j.bmcl.2016.07.036
Bacillus subtilis Bacillus subtilis MIC 128000.0 nM 10.1021/acs.jmedchem.1c02122
Campylobacter coli Campylobacter coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2020.112278
Candida albicans Candida albicans MIC nan None 10.1021/acs.jnatprod.0c00758
Chlorocebus sabaeus Vero CC50 nan None 10.1016/j.bmc.2022.116777
Corynebacterium Corynebacterium IZ 8.0 mm 10.1016/j.bmcl.2021.128381
Corynebacterium Corynebacterium IZ 20.0 mm 10.1016/j.bmcl.2021.128381
Enterobacter cloacae Enterobacter cloacae MBC 8.6 10'-2mmol/ml 10.1039/C8MD00076J
Enterobacter cloacae Enterobacter cloacae MBC99.5 8.6 10'-2microM 10.1016/j.bmc.2018.08.004
Enterobacter cloacae Enterobacter cloacae MBC99.5 8.6 10'-2 umol/ml 10.1039/C7MD00334J
Enterobacter cloacae Enterobacter cloacae MIC 4.3 10'-2mmol/ml 10.1039/C8MD00076J
Enterobacter cloacae Enterobacter cloacae MIC 4.3 10'-2 umol/ml 10.1039/C7MD00334J
Enterobacter cloacae Enterobacter cloacae MIC 43.0 nM 10.1016/j.bmc.2018.08.004
Enterococcus faecalis Enterococcus faecalis MIC 5240.0 nM 10.1016/j.bmcl.2018.01.062
Enterococcus faecalis Enterococcus faecalis MIC 16000.0 nM 10.1021/acs.jmedchem.1c00614
Enterococcus faecalis Enterococcus faecalis MIC 128000.0 nM 10.1021/acs.jmedchem.1c02122
Enterococcus faecium Enterococcus faecium MIC 16000.0 nM 10.1021/acs.jmedchem.1c02122
Escherichia coli Escherichia coli Activity 500.0 ug ml-1 10.1016/j.bmc.2017.09.035
Escherichia coli Escherichia coli IZ 13.0 mm 10.1016/j.bmcl.2018.09.021
Escherichia coli Escherichia coli IZ 16.4 mm 10.1039/d2md00192f
Escherichia coli Escherichia coli IZ 18.0 mm 10.1039/d2md00076h
Escherichia coli Escherichia coli IZ 20.0 mm 10.1039/d2md00076h
Escherichia coli Escherichia coli IZ 22.0 mm 10.1016/j.ejmech.2020.112832
Escherichia coli Escherichia coli IZ 22.2 mm 10.1016/j.bmcl.2020.127558
Escherichia coli Escherichia coli IZ 29.0 mm 10.1016/j.ejmech.2018.09.055
Escherichia coli Escherichia coli MBC 0.2 mg/ml 10.1016/j.bmcl.2020.127718
Escherichia coli Escherichia coli MBC 34.4 10'-2mmol/ml 10.1039/C8MD00076J
Escherichia coli Escherichia coli MBC 516.3 uM 10.1021/acs.jnatprod.8b00970
Escherichia coli Escherichia coli MBC99.5 34.4 10'-2microM 10.1016/j.bmc.2018.08.004
Escherichia coli Escherichia coli MBC99.5 34.4 10'-2 umol/ml 10.1039/C7MD00334J
Escherichia coli Escherichia coli MBC99.5 51.6 10'-2microM 10.1016/j.bmc.2018.08.004
Escherichia coli Escherichia coli MIC 0.05333 ug.mL-1 10.1016/j.ejmech.2022.114108
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.0c01309
Escherichia coli Escherichia coli MIC 0.256 ug.mL-1 10.1016/j.ejmech.2022.114108
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.5b00436
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Escherichia coli Escherichia coli MIC 2.3 ug.mL-1 10.1021/acs.jnatprod.0c00758
Escherichia coli Escherichia coli MIC 2.4 ug.mL-1 10.1021/acs.jnatprod.5b00008
Escherichia coli Escherichia coli MIC 5.0 ug.mL-1 10.1039/d2md00192f
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1016/j.ejmech.2020.112832
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2021.128381
Escherichia coli Escherichia coli MIC 17.2 10'-2mmol/ml 10.1039/C8MD00076J
Escherichia coli Escherichia coli MIC 17.2 10'-2 umol/ml 10.1039/C7MD00334J
Escherichia coli Escherichia coli MIC 17.25 ug.mL-1 10.1016/j.ejmech.2018.11.025
Escherichia coli Escherichia coli MIC 25.0 ug 10.1016/j.bmcl.2018.09.021
Escherichia coli Escherichia coli MIC 25.0 ug.mL-1 10.1021/acs.jnatprod.8b00015
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1016/j.bmcl.2020.127718
Escherichia coli Escherichia coli MIC 172.0 nM 10.1016/j.bmc.2018.08.004
Escherichia coli Escherichia coli MIC 250.0 nM 10.1021/acs.jmedchem.1c02122
Escherichia coli Escherichia coli MIC 258.0 nM 10.1016/j.bmc.2018.08.004
Escherichia coli Escherichia coli MIC 2200.0 ug.mL-1 10.1016/j.ejmech.2021.113921
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli MIC 5300.0 nM 10.1016/j.bmcl.2020.127558
Escherichia coli Escherichia coli MIC 21500.0 nM 10.1016/j.ejmech.2019.111708
Escherichia coli Escherichia coli MIC 344200.0 nM 10.1021/acs.jnatprod.8b00970
Homo sapiens Cytochrome P450 2C9 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens MCF7 FC 2.0 None 10.1039/C7MD00285H
Homo sapiens microRNA 21 FC 1.1 None 10.1016/j.bmc.2022.116803
Homo sapiens microRNA 21 Inhibition 80.0 % 10.1016/j.bmc.2022.116803
Homo sapiens microRNA 21 Inhibition 107.0 % 10.1039/c8md00092a
Homo sapiens THP-1 Activity 55.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 69.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 75.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 77.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 80.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 84.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 86.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 89.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 90.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 98.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 99.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 Activity 100.0 % 10.1016/j.ejmech.2018.02.067
Homo sapiens THP-1 IC50 258000.0 nM 10.1016/j.ejmech.2018.02.067
Klebsiella aerogenes Klebsiella aerogenes IZ 22.0 mm 10.1016/j.bmcl.2016.07.036
Klebsiella aerogenes Klebsiella aerogenes MIC 250.0 nM 10.1021/acs.jmedchem.1c02122
Klebsiella aerogenes Klebsiella aerogenes MIC 25000.0 nM 10.1016/j.bmcl.2016.07.036
Klebsiella pneumoniae Klebsiella pneumoniae IZ 14.0 mm 10.1016/j.bmcl.2021.128381
Klebsiella pneumoniae Klebsiella pneumoniae IZ 18.0 mm 10.1039/d2md00076h
Klebsiella pneumoniae Klebsiella pneumoniae IZ 20.0 mm 10.1016/j.bmcl.2016.07.036
Klebsiella pneumoniae Klebsiella pneumoniae MBC 1.3 umol/L 10.1016/j.bmcl.2016.07.020
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2021.128381
Klebsiella pneumoniae Klebsiella pneumoniae MIC 170.0 nM 10.1021/acs.jmedchem.1c02122
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1000.0 nM 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6250.0 nM 10.1016/j.bmcl.2016.07.036
Listeria monocytogenes Listeria monocytogenes MBC 0.3 mg/ml 10.1016/j.bmcl.2020.127718
Listeria monocytogenes Listeria monocytogenes MBC 516.3 uM 10.1021/acs.jnatprod.8b00970
Listeria monocytogenes Listeria monocytogenes MBC99.5 51.6 10'-2microM 10.1016/j.bmc.2018.08.004
Listeria monocytogenes Listeria monocytogenes MBC99.5 51.6 10'-2 umol/ml 10.1039/C7MD00334J
Listeria monocytogenes Listeria monocytogenes MIC 25.8 10'-2 umol/ml 10.1039/C7MD00334J
Listeria monocytogenes Listeria monocytogenes MIC 150.0 ug.mL-1 10.1016/j.bmcl.2020.127718
Listeria monocytogenes Listeria monocytogenes MIC 258.0 nM 10.1016/j.bmc.2018.08.004
Listeria monocytogenes Listeria monocytogenes MIC 344200.0 nM 10.1021/acs.jnatprod.8b00970
Micrococcus flavus Micrococcus flavus MBC 516.3 uM 10.1021/acs.jnatprod.8b00970
Micrococcus flavus Micrococcus flavus MBC99.5 17.2 10'-2microM 10.1016/j.bmc.2018.08.004
Micrococcus flavus Micrococcus flavus MBC99.5 17.2 10'-2 umol/ml 10.1039/C7MD00334J
Micrococcus flavus Micrococcus flavus MIC 8.6 10'-2 umol/ml 10.1039/C7MD00334J
Micrococcus flavus Micrococcus flavus MIC 86.0 nM 10.1016/j.bmc.2018.08.004
Micrococcus flavus Micrococcus flavus MIC 344200.0 nM 10.1021/acs.jnatprod.8b00970
Micrococcus luteus Micrococcus luteus IZ 22.5 mm 10.1016/j.bmc.2017.08.042
Micrococcus luteus Micrococcus luteus IZ 26.0 mm 10.1016/j.bmcl.2016.07.036
Micrococcus luteus Micrococcus luteus MBC 6.25 ug ml-1 10.1016/j.bmc.2017.08.042
Micrococcus luteus Micrococcus luteus MIC 6.25 ug.mL-1 10.1016/j.bmc.2017.08.042
Micrococcus luteus Micrococcus luteus MIC 6250.0 nM 10.1016/j.bmcl.2016.07.036
Mycobacterium intracellulare Mycobacterium intracellulare Activity nan None 10.1021/acs.jnatprod.7b00903
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1021/acs.jnatprod.7b00903
Mycobacterium tuberculosis Mycobacterium tuberculosis MBC nan None 10.1016/j.ejmech.2018.02.067
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.09 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.19 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.3 ug.mL-1 10.1021/acs.jnatprod.0c01212
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.39 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.49 ug.mL-1 10.1016/j.ejmech.2022.114145
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.08.002
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1016/j.ejmech.2020.112045
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.5 ug.mL-1 10.1016/j.ejmech.2021.113580
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.7 ug.mL-1 10.1016/j.ejmech.2018.03.016
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.78 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.8 ug.mL-1 10.1016/j.bmcl.2020.127655
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.bmc.2022.116777
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2019.111882
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2020.112996
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2021.113580
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1039/d1md00387a
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.25 ug.mL-1 10.1039/C7MD00366H
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.56 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.56 ug.mL-1 10.1039/C7MD00350A
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2021.113580
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2022.114145
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1016/j.ejmech.2022.114454
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.1 ug.mL-1 10.1016/j.ejmech.2019.111882
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.1 ug.mL-1 10.1021/acs.jnatprod.8b00650
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.125 ug.mL-1 10.1016/j.ejmech.2022.114454
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.13 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1016/j.ejmech.2018.12.001
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2018.03.016
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2018.11.025
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2020.112666
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2020.112886
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2021.113266
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2022.114454
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1039/d2md00076h
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.111882
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 25.0 ug.mL-1 10.1016/j.ejmech.2019.111882
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 25.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 50.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 64.0 ug.mL-1 10.1016/j.bmc.2022.116777
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113580
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 64.0 ug.mL-1 10.1039/d1md00387a
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 100.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 430.0 nM 10.1016/j.ejmech.2018.02.067
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 480.0 nM 10.1039/C7MD00146K
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 690.0 nM 10.1016/j.ejmech.2020.112898
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1320.0 nM 10.1021/acs.jmedchem.1c00168
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1320.0 nM 10.1021/acs.jmedchem.7b01903
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4000.0 nM 10.1016/j.bmc.2018.07.049
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 10700.0 nM 10.1016/j.bmcl.2016.08.045
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 69000.0 nM 10.1016/j.ejmech.2018.02.067
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 87830.0 nM 10.1016/j.ejmech.2020.112898
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=>80 0.3 uM 10.1039/C5MD00589B
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=>80 11.0 uM 10.1039/C5MD00589B
Mycobacterium tuberculosis Mycobacterium tuberculosis Ratio nan None 10.1016/j.ejmech.2018.02.067
Mycobacteroides abscessus Mycobacteroides abscessus MIC nan None 10.1016/j.bmc.2022.116777
Mycobacteroides abscessus Mycobacteroides abscessus MIC nan None 10.1016/j.ejmech.2020.112996
Mycobacteroides chelonae Mycobacteroides chelonae MIC nan None 10.1016/j.bmc.2022.116777
Mycobacteroides chelonae Mycobacteroides chelonae MIC nan None 10.1016/j.ejmech.2020.112996
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC nan None 10.1016/j.bmc.2022.116777
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC nan None 10.1016/j.ejmech.2020.112996
Mycolicibacterium phlei Mycolicibacterium phlei MIC 6.25 ug.mL-1 10.1016/j.ejmech.2020.112886
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 4.0 ug.mL-1 10.1016/j.ejmech.2020.112886
Proteus vulgaris Proteus vulgaris MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112278
Providencia alcalifaciens Providencia alcalifaciens MIC 9300.0 nM 10.1021/acs.jmedchem.1c02122
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 52.5 % 10.1021/acs.jnatprod.8b00970
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 74.6 % 10.1021/acs.jnatprod.8b00970
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 89.3 % 10.1021/acs.jnatprod.8b00970
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 11.0 mm 10.1016/j.bmcl.2021.128381
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 15.0 mm 10.1016/j.bmcl.2021.128381
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 16.0 mm 10.1039/d2md00076h
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 24.0 mm 10.1016/j.ejmech.2018.09.055
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 25.0 mm 10.1016/j.bmcl.2020.127558
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 0.1 mg/ml 10.1016/j.bmcl.2020.127718
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 0.2 mg/ml 10.1016/j.bmcl.2020.127718
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 17.2 10'-2mmol/ml 10.1039/C8MD00076J
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 34.4 10'-2mmol/ml 10.1039/C8MD00076J
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 516.3 uM 10.1021/acs.jnatprod.8b00970
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC99.5 25.8 10'-2microM 10.1016/j.bmc.2018.08.004
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC99.5 34.4 10'-2microM 10.1016/j.bmc.2018.08.004
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC99.5 34.4 10'-2 umol/ml 10.1039/C7MD00334J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.0c01309
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.7 ug.mL-1 10.1021/acs.jnatprod.5b00008
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.2 ug.mL-1 10.1021/acs.jnatprod.8b00650
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.ejmech.2020.112278
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.6 10'-2mmol/ml 10.1039/C8MD00076J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10.0 ug.mL-1 10.1021/acs.jnatprod.5b00436
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 17.2 10'-2mmol/ml 10.1039/C8MD00076J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 17.2 10'-2 umol/ml 10.1039/C7MD00334J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 17.25 ug.mL-1 10.1016/j.ejmech.2018.11.025
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50.0 ug.mL-1 10.1016/j.bmcl.2020.127718
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 100.0 ug.mL-1 10.1016/j.bmcl.2020.127718
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 129.0 nM 10.1016/j.bmc.2018.08.004
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 172.0 nM 10.1016/j.bmc.2018.08.004
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2200.0 ug.mL-1 10.1016/j.ejmech.2021.113921
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 5300.0 nM 10.1016/j.bmcl.2020.127558
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16000.0 nM 10.1021/acs.jmedchem.1c02122
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 21500.0 nM 10.1016/j.ejmech.2019.111708
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 344200.0 nM 10.1021/acs.jnatprod.8b00970
Salmonella enterica Salmonella enterica MIC 330.0 nM 10.1021/acs.jmedchem.1c02122
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi IZ 30.0 mm 10.1016/j.bmc.2017.08.042
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MBC 6.25 ug ml-1 10.1016/j.bmc.2017.08.042
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC 6.25 ug.mL-1 10.1016/j.bmc.2017.08.042
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi IZ 27.0 mm 10.1016/j.bmc.2017.08.042
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi IZ 29.1 mm 10.1016/j.bmcl.2020.127558
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MBC 6.25 ug ml-1 10.1016/j.bmc.2017.08.042
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC 6.25 ug.mL-1 10.1016/j.bmc.2017.08.042
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC 5300.0 nM 10.1016/j.bmcl.2020.127558
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium IZ 18.0 mm 10.1016/j.bmcl.2016.07.036
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium IZ 18.0 mm 10.1039/d2md00076h
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC 0.2 mg/ml 10.1016/j.bmcl.2020.127718
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC99.5 34.4 10'-2microM 10.1016/j.bmc.2018.08.004
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC99.5 34.4 10'-2 umol/ml 10.1039/C7MD00334J
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 17.2 10'-2 umol/ml 10.1039/C7MD00334J
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 100.0 ug.mL-1 10.1016/j.bmcl.2020.127718
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 172.0 nM 10.1016/j.bmc.2018.08.004
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 30000.0 nM 10.1016/j.bmcl.2016.07.036
Shigella flexneri Shigella flexneri IZ 30.0 mm 10.1016/j.bmcl.2016.07.036
Shigella flexneri Shigella flexneri MIC 6250.0 nM 10.1016/j.bmcl.2016.07.036
Shigella sonnei Shigella sonnei MIC 250.0 nM 10.1021/acs.jmedchem.1c02122
Staphylococcus aureus Staphylococcus aureus Activity 500.0 ug ml-1 10.1016/j.bmc.2017.09.035
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2017.11.018
Staphylococcus aureus Staphylococcus aureus IZ 2.0 mm 10.1016/j.bmcl.2021.128381
Staphylococcus aureus Staphylococcus aureus IZ 4.0 mm 10.1016/j.bmcl.2021.128381
Staphylococcus aureus Staphylococcus aureus IZ 8.0 mm 10.1016/j.bmcl.2021.128381
Staphylococcus aureus Staphylococcus aureus IZ 14.0 mm 10.1016/j.bmcl.2016.07.036
Staphylococcus aureus Staphylococcus aureus IZ 16.0 mm 10.1039/d2md00076h
Staphylococcus aureus Staphylococcus aureus IZ 18.0 mm 10.1016/j.ejmech.2017.11.026
Staphylococcus aureus Staphylococcus aureus IZ 18.0 mm 10.1039/d2md00076h
Staphylococcus aureus Staphylococcus aureus IZ 20.0 mm 10.1016/j.ejmech.2020.112832
Staphylococcus aureus Staphylococcus aureus IZ 20.3 mm 10.1016/j.bmc.2017.08.042
Staphylococcus aureus Staphylococcus aureus IZ 20.3 mm 10.1016/j.ejmech.2019.111892
Staphylococcus aureus Staphylococcus aureus IZ 21.0 mm 10.1016/j.ejmech.2018.09.055
Staphylococcus aureus Staphylococcus aureus IZ 30.0 mm 10.1016/j.bmcl.2016.07.036
Staphylococcus aureus Staphylococcus aureus IZ 30.6 mm 10.1016/j.bmcl.2020.127558
Staphylococcus aureus Staphylococcus aureus MBC 0.3 mg/ml 10.1016/j.bmcl.2020.127718
Staphylococcus aureus Staphylococcus aureus MBC 34.4 10'-2mmol/ml 10.1039/C8MD00076J
Staphylococcus aureus Staphylococcus aureus MBC99.5 34.4 10'-2microM 10.1016/j.bmc.2018.08.004
Staphylococcus aureus Staphylococcus aureus MBC99.5 34.4 10'-2 umol/ml 10.1039/C7MD00334J
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/acs.jnatprod.0c00758
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.0c01309
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1016/j.bmc.2021.116580
Staphylococcus aureus Staphylococcus aureus MIC 1.7 ug.mL-1 10.1016/j.bmc.2021.116580
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Staphylococcus aureus Staphylococcus aureus MIC 3.5 ug.mL-1 10.1016/j.bmc.2021.116580
Staphylococcus aureus Staphylococcus aureus MIC 4.3 10'-2mmol/ml 10.1039/C8MD00076J
Staphylococcus aureus Staphylococcus aureus MIC 5.0 ug.mL-1 10.1021/acs.jnatprod.5b00436
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1016/j.ejmech.2020.112832
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112278
Staphylococcus aureus Staphylococcus aureus MIC 17.2 10'-2mmol/ml 10.1039/C8MD00076J
Staphylococcus aureus Staphylococcus aureus MIC 17.2 10'-2 umol/ml 10.1039/C7MD00334J
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2020.112278
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/j.bmcl.2020.127718
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/j.ejmech.2021.113442
Staphylococcus aureus Staphylococcus aureus MIC 150.0 ug.mL-1 10.1016/j.bmcl.2020.127718
Staphylococcus aureus Staphylococcus aureus MIC 172.0 nM 10.1016/j.bmc.2018.08.004
Staphylococcus aureus Staphylococcus aureus MIC 258.0 nM 10.1016/j.bmc.2018.08.004
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus aureus Staphylococcus aureus MIC 2090.0 nM 10.1016/j.bmcl.2018.01.062
Staphylococcus aureus Staphylococcus aureus MIC 2200.0 nM 10.1016/j.ejmech.2021.113447
Staphylococcus aureus Staphylococcus aureus MIC 2200.0 ug.mL-1 10.1016/j.ejmech.2021.113921
Staphylococcus aureus Staphylococcus aureus MIC 2700.0 nM 10.1021/acs.jmedchem.1c02122
Staphylococcus aureus Staphylococcus aureus MIC 5300.0 nM 10.1016/j.bmcl.2020.127558
Staphylococcus aureus Staphylococcus aureus MIC 6250.0 nM 10.1016/j.bmcl.2016.07.036
Staphylococcus aureus Staphylococcus aureus MIC 9300.0 nM 10.1021/acs.jmedchem.1c02122
Staphylococcus aureus Staphylococcus aureus MIC 21500.0 nM 10.1016/j.ejmech.2019.111708
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/acs.jnatprod.5b00641
Staphylococcus epidermidis Staphylococcus epidermidis IZ 23.0 mm 10.1016/j.ejmech.2018.09.055
Staphylococcus epidermidis Staphylococcus epidermidis IZ 25.0 mm 10.1016/j.bmcl.2016.07.036
Staphylococcus epidermidis Staphylococcus epidermidis MIC 2700.0 nM 10.1021/acs.jmedchem.1c02122
Staphylococcus epidermidis Staphylococcus epidermidis MIC 25000.0 nM 10.1016/j.bmcl.2016.07.036
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus intermedius Staphylococcus intermedius MIC 10700.0 nM 10.1016/j.ejmech.2019.111708
Streptococcus pneumoniae Streptococcus pneumoniae MIC 48000.0 nM 10.1021/acs.jmedchem.1c02122
Streptococcus pyogenes Streptococcus pyogenes IZ 2.0 mm 10.1016/j.bmcl.2021.128381
Streptococcus pyogenes Streptococcus pyogenes IZ 3.0 mm 10.1016/j.bmcl.2021.128381
Streptococcus pyogenes Streptococcus pyogenes IZ 10.0 mm 10.1016/j.bmcl.2021.128381
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmcl.2021.128381
Streptomyces scabiei Streptomyces scabiei MIC 5.8 ug.mL-1 10.1021/acs.jnatprod.5b00641
Vibrio cholerae Vibrio cholerae MIC 13000.0 nM 10.1021/acs.jmedchem.1c02122
Yersinia pseudotuberculosis Yersinia pseudotuberculosis MIC 6700.0 nM 10.1021/acs.jmedchem.1c02122
None ADMET CL 30.0 ml/min 10.1021/acs.jmedchem.0c01177
None ADMET Cmax 43000.0 nM 10.1021/acs.jmedchem.0c01177
None ADMET Drugexcretion 39.0 % 10.1021/acs.jmedchem.0c01177
None ADMET F 80.0 % 10.1021/acs.jmedchem.0c01177
None ADMET PPB 48.0 % 10.1021/acs.jmedchem.0c01177
None ADMET Selectivity Index nan None 10.1016/j.bmc.2022.116777
None ADMET T1/2 5.3 hr 10.1021/acs.jmedchem.0c01177
None ADMET Tmax 0.5 hr 10.1021/acs.jmedchem.0c01177
None ADMET Vdss 1.77 L.kg-1 10.1021/acs.jmedchem.0c01177
None No relevant target LogP 8.01 None 10.1016/j.bmc.2018.07.049
None Unchecked FC 1.4 None 10.1039/C7MD00285H
None Unchecked FC 2.0 None 10.1039/C7MD00285H
None Unchecked Inhibition 25.0 % 10.1016/j.ejmech.2019.112008
None Unchecked MIC 6.25 ug.mL-1 10.1016/j.bmcl.2020.127603
None Unchecked MIC 4000.0 nM 10.1021/acs.jmedchem.1c02122
None Unchecked MIC 128000.0 nM 10.1021/acs.jmedchem.1c02122
None Unchecked Selectivity Index 600.0 None 10.1016/j.ejmech.2018.02.067

Metabolism Information