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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK322697

Synonym: None

IUPAC Name: 2-aminoguanidine

Structure

SMILES: N=C(N)NN

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InChI: InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)

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InChIKey: HAMNKKUPIHEESI-UHFFFAOYSA-N

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Reference

PubChem CID: 2146

CAS: 28128-41-8

NPASS: NPC482298

Properties Information

Molecule Weight: 74.087

TPSA？: 87.92

MolLogP？: -1.6568300000000002

Number of H-Donors: 4

Number of H-Acceptors: 2

RingCount: 0

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 31622.8 nM None
Bos taurus Catalase IC50 500000.0 nM 10.1021/jf200485k
Bos taurus Serum albumin EC50 26000000.0 nM 10.1021/acs.jnatprod.6b00823
Bos taurus Serum albumin Inhibition nan % 10.1021/acs.jnatprod.6b00823
Gossypium hirsutum Gossypium hirsutum Activity nan None 10.1021/jf200485k
Homo sapiens Cytochrome P450 1A2 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 AC50 15848.93 nM None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Diamine oxidase Ki 140.0 nM 10.1016/S0960-894X(01)80909-4
Homo sapiens Dipeptidyl peptidase IV IC50 nan None 10.1016/j.ejmech.2019.111808
Homo sapiens Dipeptidyl peptidase IV Inhibition nan % 10.1016/j.ejmech.2019.111808
Homo sapiens DLD-1 IC50 1000000.0 nM 10.1021/jm0255926
Homo sapiens Flap endonuclease 1 Potency 8436.8 nM None
Homo sapiens HEK293 Potency 259.2 nM None
Homo sapiens Histone deacetylase 6 Inhibition -19.55 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -11.6 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 42284.1 nM None
Homo sapiens Lysine-specific histone demethylase 1 Inhibition nan % 10.1021/jm3002845
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens Microtubule-associated protein tau Potency 14125.4 nM None
Homo sapiens Nitric-oxide synthase, brain IC50 5900.0 nM 10.1021/jm0255926
Homo sapiens Nitric-oxide synthase, brain IC50 118000.0 nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric-oxide synthase, brain Ki 3300.0 nM 10.1016/j.bmc.2008.04.036
Homo sapiens Nitric-oxide synthase, endothelial IC50 72000.0 nM 10.1016/s0960-894x(01)00119-6
Homo sapiens Nitric-oxide synthase, endothelial IC50 100000.0 nM 10.1021/jm0255926
Homo sapiens Nitric-oxide synthase, endothelial IC50 500000.0 nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric-oxide synthase, endothelial IC50 nan nM 10.1016/0960-894X(95)00273-V
Homo sapiens Nitric oxide synthase, inducible IC50 3900.0 nM 10.1021/jm0255926
Homo sapiens Nitric oxide synthase, inducible IC50 4500.0 nM 10.1016/s0960-894x(01)00119-6
Homo sapiens Nitric oxide synthase, inducible IC50 54000.0 nM 10.1016/0960-894X(95)00273-V
Homo sapiens Nitric oxide synthase, inducible IC50 101000.0 nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric oxide synthase, inducible IC50 1100000000.0 nM 10.1016/s0960-894x(01)00119-6
Homo sapiens Nitric oxide sythases; iNOS & nNOS Selectivity 1.1 None 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric oxide sythases; iNOS & nNOS Selectivity 5.0 None 10.1016/s0960-894x(00)00389-9
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 3.5 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 75.2 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 3981.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 6683.8 nM None
Homo sapiens Zone of skin Activity 49.7 % 10.1021/acs.jnatprod.9b01083
Mus musculus BV-2 MNTD 1000.0 uM 10.1016/j.bmcl.2013.04.072
Mus musculus FL5.12 Activity 3.0 % 10.1016/j.bmcl.2007.06.009
Mus musculus FL5.12 Activity 3.72 % 10.1021/jm070794t
Mus musculus FL5.12 Activity 5.0 % 10.1016/j.bmcl.2007.06.009
Mus musculus FL5.12 Activity 5.17 % 10.1021/jm070794t
Mus musculus FL5.12 Activity 79.69 % 10.1021/jm070794t
Mus musculus FL5.12 Activity 80.0 % 10.1016/j.bmcl.2007.06.009
Mus musculus Mus musculus IC50 25100.0 nM 10.1021/jm991085l
Mus musculus Nitric oxide synthase, inducible Activity 2.7 pmol/min 10.1016/j.bmcl.2011.02.071
Mus musculus Nitric oxide synthase, inducible Activity 5.4 pM of citrulline min-1 (mg of protein)-1 10.1021/jm991085l
Mus musculus Nitric oxide synthase, inducible Emax 80.35 % 10.1021/np200279r
Mus musculus Nitric oxide synthase, inducible Emax 83.5 % 10.1021/np100874f
Mus musculus Nitric oxide synthase, inducible IC50 9000.0 nM 10.1016/0960-894X(95)00273-V
Mus musculus Nitric oxide synthase, inducible IC50 26550.0 nM 10.1021/np200279r
Mus musculus Nitric oxide synthase, inducible IC50 28470.0 nM 10.1021/np100874f
Mus musculus Nitric oxide synthase, inducible Inhibition nan % 10.1016/j.bmcl.2011.02.071
Mus musculus RAW Inhibition 85.0 % 10.1016/j.bmcl.2007.04.005
Mus musculus RAW264.7 Activity 84.6 % 10.1021/np3002173
Mus musculus RAW264.7 Activity 90.0 % 10.1016/j.bmcl.2013.08.004
Mus musculus RAW264.7 Activity 99.2 % 10.1021/acs.jnatprod.6b00407
Mus musculus RAW264.7 Activity 100.2 % 10.1016/j.ejmech.2014.06.045
Mus musculus RAW264.7 Activity nan None 10.1016/j.bmcl.2013.01.091
Mus musculus RAW264.7 Activity nan None 10.1016/j.bmcl.2014.12.012
Mus musculus RAW264.7 CC50 100000.0 nM 10.1021/np100874f
Mus musculus RAW264.7 Emax 83.7 % 10.1021/acs.jnatprod.6b00407
Mus musculus RAW264.7 IC50 3.3 ug.mL-1 10.1016/j.bmc.2009.11.055
Mus musculus RAW264.7 IC50 3.4 ug.mL-1 10.1021/np800790h
Mus musculus RAW264.7 IC50 50.0 nM 10.1021/np9005053
Mus musculus RAW264.7 IC50 200.0 nM 10.1016/j.ejmech.2011.08.047
Mus musculus RAW264.7 IC50 230.0 nM 10.1016/j.bmcl.2014.08.004
Mus musculus RAW264.7 IC50 1800.0 nM 10.1016/j.ejmech.2021.113165
Mus musculus RAW264.7 IC50 2700.0 nM 10.1021/np100124a
Mus musculus RAW264.7 IC50 4060.0 nM 10.1021/np030139y
Mus musculus RAW264.7 IC50 4600.0 nM 10.1021/np1003627
Mus musculus RAW264.7 IC50 6500.0 nM 10.1021/np3002173
Mus musculus RAW264.7 IC50 7290.0 nM 10.1016/j.ejmech.2015.02.016
Mus musculus RAW264.7 IC50 7900.0 nM 10.1021/np200319x
Mus musculus RAW264.7 IC50 8680.0 nM 10.1016/j.ejmech.2014.06.043
Mus musculus RAW264.7 IC50 11910.0 nM 10.1016/j.ejmech.2015.07.051
Mus musculus RAW264.7 IC50 16300.0 nM 10.1021/np010428r
Mus musculus RAW264.7 IC50 16600.0 nM 10.1016/j.bmcl.2013.08.004
Mus musculus RAW264.7 IC50 16900.0 nM 10.1016/j.bmcl.2014.04.046
Mus musculus RAW264.7 IC50 17500.0 nM 10.1016/j.bmcl.2010.04.054
Mus musculus RAW264.7 IC50 17500.0 nM 10.1016/j.bmcl.2011.10.043
Mus musculus RAW264.7 IC50 17500.0 nM 10.1021/acs.jnatprod.7b00619
Mus musculus RAW264.7 IC50 18700.0 nM 10.1016/j.bmcl.2013.01.091
Mus musculus RAW264.7 IC50 18700.0 nM 10.1016/j.bmcl.2014.12.012
Mus musculus RAW264.7 IC50 18700.0 nM 10.1016/j.bmcl.2016.05.035
Mus musculus RAW264.7 IC50 18700.0 nM 10.1021/acs.jnatprod.0c00842
Mus musculus RAW264.7 IC50 18700.0 nM 10.1021/acs.jnatprod.5b00789
Mus musculus RAW264.7 IC50 19900.0 nM 10.1021/acs.jnatprod.9b00849
Mus musculus RAW264.7 IC50 20600.0 nM 10.1016/j.bmcl.2015.05.062
Mus musculus RAW264.7 IC50 20600.0 nM 10.1021/acs.jnatprod.5b00126
Mus musculus RAW264.7 IC50 20700.0 nM 10.1021/acs.jnatprod.0c01121
Mus musculus RAW264.7 IC50 21000.0 nM 10.1021/np8004166
Mus musculus RAW264.7 IC50 21400.0 nM 10.1021/np400831p
Mus musculus RAW264.7 IC50 21700.0 nM 10.1021/acs.jnatprod.9b00155
Mus musculus RAW264.7 IC50 22300.0 nM 10.1021/np400523k
Mus musculus RAW264.7 IC50 22600.0 nM 10.1016/j.ejmech.2012.01.036
Mus musculus RAW264.7 IC50 24700.0 nM 10.1021/acs.jnatprod.6b00407
Mus musculus RAW264.7 IC50 25500.0 nM 10.1021/acs.jnatprod.9b00520
Mus musculus RAW264.7 IC50 27500.0 nM 10.1021/np200439n
Mus musculus RAW264.7 IC50 28000.0 nM 10.1021/np800418j
Mus musculus RAW264.7 IC50 32170.0 nM 10.1021/np060638+
Mus musculus RAW264.7 IC50 32200.0 nM 10.1016/j.bmcl.2010.11.095
Mus musculus RAW264.7 IC50 32200.0 nM 10.1021/np0705965
Mus musculus RAW264.7 IC50 43300.0 nM 10.1016/j.ejmech.2014.06.045
Mus musculus RAW264.7 IC50 nan None 10.1016/j.bmcl.2013.01.091
Mus musculus RAW264.7 IC50 nan None 10.1016/j.ejmech.2014.06.043
Mus musculus RAW264.7 IC50 nan None 10.1016/j.ejmech.2015.07.051
Mus musculus RAW264.7 IC50 nan None 10.1021/np400831p
Mus musculus RAW264.7 IC50 nan None 10.1021/np800790h
Mus musculus RAW264.7 Inhibition 8.0 % 10.1016/j.bmc.2011.01.034
Mus musculus RAW264.7 Inhibition 21.0 % 10.1016/j.bmc.2011.01.034
Mus musculus RAW264.7 Inhibition 42.0 % 10.1016/j.bmc.2011.01.034
Mus musculus RAW264.7 Inhibition 52.5 % 10.1016/j.bmc.2011.04.006
Mus musculus RAW264.7 Inhibition 56.0 % 10.1016/j.bmcl.2013.01.091
Mus musculus RAW264.7 Inhibition 70.2 % 10.1016/j.ejmech.2014.06.045
Mus musculus RAW264.7 Inhibition 71.0 % 10.1016/j.bmcl.2013.01.091
Mus musculus RAW264.7 Inhibition 74.0 % 10.1016/j.bmcl.2012.03.010
Mus musculus RAW264.7 Inhibition 74.9 % 10.1016/j.bmc.2011.04.006
Mus musculus RAW264.7 Inhibition 78.8 % 10.1021/np990116c
Mus musculus RAW264.7 Inhibition 79.0 % 10.1016/s0960-894x(01)00812-5
Mus musculus RAW264.7 Inhibition 83.8 % 10.1016/j.ejmech.2014.06.043
Mus musculus RAW264.7 Inhibition 86.0 % 10.1016/j.bmc.2011.04.006
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmc.2011.06.069
Mus musculus RAW264.7 Survival 100.0 % 10.1016/j.ejmech.2014.06.043
Rattus norvegicus Aldose reductase IC50 30000.0 nM 10.1021/np200646e
Rattus norvegicus Nitric-oxide synthase, brain IC50 6000.0 nM 10.1016/s0960-894x(01)00119-6
Rattus norvegicus Nitric-oxide synthase, brain IC50 19410.0 nM 10.1016/j.bmc.2011.05.034
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan nM 10.1016/0960-894X(95)00273-V
Rattus norvegicus Nitric oxide synthase, inducible IC50 132010.0 nM 10.1016/j.bmc.2013.05.064
Rattus norvegicus Nitric oxide synthase, inducible Inhibition 10.0 % 10.1016/j.bmc.2013.05.064
Rattus norvegicus Rattus norvegicus Activity 1.33 % 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 3.27 % 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 5.07 mmol/L 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 5.23 mmol/L 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 9.16 % 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 12.71 % 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 21.74 mmol/L 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 21.89 mmol/L 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 219.5 g 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 284.5 g 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 536.5 g 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity 553.0 g 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2012.10.010
Rattus norvegicus Rattus norvegicus ID50 nan umol.kg-1 10.1021/jm0255926
Rattus norvegicus Rattus norvegicus Ratio 2.95 None 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Ratio 3.06 None 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Ratio 3.46 None 10.1016/j.bmcl.2012.04.130
Rattus norvegicus Rattus norvegicus Ratio 3.71 None 10.1016/j.bmcl.2012.04.130
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 12.23 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 25.83 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.03 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.02 % 10.6019/CHEMBL4495565
Vitis vinifera Vitis vinifera Activity nan None 10.1021/jf200485k
Zea mays Zea mays Activity nan None 10.1021/jf200485k
None ADMET Activity 94.0 % 10.1016/j.bmc.2009.02.018
None ADMET Activity nan None 10.1016/j.bmc.2013.05.064
None ADMET TI 16.0 None 10.1016/j.bmc.2011.01.034
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None NON-PROTEIN TARGET Activity 75.0 % 10.1016/j.bmc.2009.02.018
None NON-PROTEIN TARGET Activity 92.2 % 10.1021/acs.jnatprod.9b01083
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2019.07.035
None NON-PROTEIN TARGET CC50 358000.0 nM 10.1016/j.bmc.2011.01.034
None NON-PROTEIN TARGET EC50 22600.0 nM 10.1016/j.bmc.2011.01.034
None NON-PROTEIN TARGET IC50 16600.0 nM 10.1016/j.bmcl.2013.04.032
None NON-PROTEIN TARGET IC50 18400.0 nM 10.1016/j.bmcl.2016.09.012
None NON-PROTEIN TARGET IC50 24200.0 nM 10.1016/j.bmcl.2016.10.017
None NON-PROTEIN TARGET IC50 765000.0 nM 10.1016/j.bmcl.2019.07.035
None NON-PROTEIN TARGET IC50 765000.0 nM 10.1016/j.ejmech.2019.111808
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmcl.2019.07.035
None NON-PROTEIN TARGET Inhibition -18.6 % 10.1016/j.bmcl.2019.07.035
None NON-PROTEIN TARGET Inhibition 6.0 % 10.1016/j.ejmech.2019.111808
None NON-PROTEIN TARGET Inhibition 57.8 % 10.1016/j.bmcl.2019.07.035
None NON-PROTEIN TARGET Inhibition 57.8 % 10.1016/j.ejmech.2019.111808
None No relevant target Activity 70.0 % 10.1016/j.bmc.2009.02.018
None No relevant target Activity 85.0 % 10.1016/j.bmc.2009.02.018
None No relevant target IC50 21700.0 nM 10.1021/acs.jnatprod.7b00619
None No relevant target IC50 40060.0 nM 10.1016/j.bmc.2017.09.012
None No relevant target IC50 40540.0 nM 10.1016/j.bmcl.2012.11.080
None No relevant target IC50 88870.0 nM 10.1016/j.bmcl.2011.04.131
None No relevant target IC50 826220.0 nM 10.1016/j.bmc.2010.03.056
None No relevant target IC50 826220.0 nM 10.1016/j.bmcl.2010.12.077
None No relevant target IC50 961000.0 nM 10.1021/np070489a
None No relevant target IC50 965900.0 nM 10.1021/np200646e
None No relevant target IC50 965900.0 nM 10.1021/np400442b
None No relevant target IC50 1000000.0 nM 10.1016/j.ejmech.2019.111808
None No relevant target IC50 1026800.0 nM 10.1021/np9002004
None No relevant target Inhibition 60.5 % 10.1021/np020256d
None No relevant target Inhibition 76.0 % 10.1021/np030323j
None No relevant target Inhibition 79.67 % 10.1016/j.bmcl.2011.04.131
None No relevant target Inhibition 1000.0 % 10.1016/j.bmcl.2019.07.035
None Unchecked Activity nan None 10.1016/j.bmcl.2015.06.080
None Unchecked IC50 150.0 ug.mL-1 10.1021/acs.jnatprod.5b00222
None Unchecked IC50 700.0 ug.mL-1 10.1021/acs.jnatprod.5b00222
None Unchecked IC50 19410.0 nM 10.1016/j.bmc.2008.08.049
None Unchecked IC50 1905460.72 nM 10.1016/j.bmc.2008.08.049
None Unchecked Inhibition nan % 10.1016/j.bmc.2011.05.034
None Unchecked Potency 2058.8 nM None
None Unchecked Potency 3162.3 nM None
None Unchecked Selectivity 10.0 None 10.1021/jm990111c
None Unchecked Selectivity 500.0 None 10.1021/jm990111c

Metabolism Information