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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK322757

Synonym: None

IUPAC Name: 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

Structure

SMILES: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)N=C1O

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InChI: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

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InChIKey: HBOMLICNUCNMMY-XLPZGREQSA-N

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Reference

PubChem CID: 35370

CAS: 30516-87-1

NPASS: NPC478793

Source

Species Genus Family Order Class Phylum Kingdom Domain
Ecklonia cava Ecklonia Lessoniaceae Laminariales Phaeophyceae None None Eukaryota
Senna siamea Senna Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stellera chamaejasme Stellera Thymelaeaceae Malvales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Salvia miltiorrhiza Salvia Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hemsleya endecaphylla Hemsleya Cucurbitaceae Cucurbitales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Annona glabra Annona Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Gardenia carinata Gardenia Rubiaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Euphorbia ebracteolata Euphorbia Euphorbiaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Eriobotrya japonica Eriobotrya Rosaceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Paepalanthus microphyllus Paepalanthus Eriocaulaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Kadsura coccinea Kadsura Schisandraceae Austrobaileyales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aplysina archeri Aplysina Aplysinidae Verongiida Demospongiae Porifera Metazoa Eukaryota
Justicia gendarussa Justicia Acanthaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Kleinhovia hospita Kleinhovia Malvaceae Malvales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Daphne genkwa Daphne Thymelaeaceae Malvales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 267.24499999999995

TPSA？: 133.34

MolLogP？: 0.2160199999999997

Number of H-Donors: 2

Number of H-Acceptors: 7

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 10000.0 nM 10.6019/CHEMBL4513141
Avian myeloblastosis virus Avian myeloblastosis virus IC50 600.0 ug.mL-1 10.1016/S0960-894X(01)80437-6
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 25118.9 nM None
Betapolyomavirus hominis BK polyomavirus EC50 100000.0 nM 10.1128/aac.01241-07
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans MIC 10000.0 nM 10.6019/CHEMBL4513141
Canis lupus familiaris MDCK MCC nan None 10.1016/j.bmc.2015.12.008
Canis lupus familiaris Plasma Fu 0.827 None 10.1124/dmd.110.037457
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus aethiops CV-1 Inhibition nan % 10.1021/jm00028a013
Chlorocebus sabaeus Vero CC50 39500.0 nM 10.1016/j.ejmech.2015.09.015
Chlorocebus sabaeus Vero CC50 53000.0 nM 10.1016/j.bmcl.2013.03.077
Chlorocebus sabaeus Vero CC50 56000.0 nM 10.1016/j.bmc.2014.10.003
Chlorocebus sabaeus Vero CC50 100000.0 nM 10.1128/aac.00392-09
Chlorocebus sabaeus Vero CC50 126000.0 nM 10.1016/j.ejmech.2008.02.047
Chlorocebus sabaeus Vero EC50 50000.0 nM 10.1021/jm00042a011
Chlorocebus sabaeus Vero EC50 100000.0 nM 10.1021/jm00115a022
Chlorocebus sabaeus Vero EC50 nan ug.mL-1 10.1016/0960-894X(95)00395-A
Chlorocebus sabaeus Vero IC50 14300.0 nM 10.1021/jm020376i
Chlorocebus sabaeus Vero IC50 26000.0 nM 10.1021/jm00115a022
Chlorocebus sabaeus Vero IC50 27700.0 nM 10.1016/0960-894X(95)00133-E
Chlorocebus sabaeus Vero IC50 27700.0 nM 10.1016/0960-894X(96)00171-0
Chlorocebus sabaeus Vero IC50 27700.0 nM 10.1016/s0960-894x(98)00278-9
Chlorocebus sabaeus Vero IC50 28000.0 nM 10.1016/0960-894X(95)00107-5
Chlorocebus sabaeus Vero IC50 28000.0 nM 10.1021/jm00053a004
Chlorocebus sabaeus Vero IC50 28000.0 nM 10.1021/jm00057a001
Chlorocebus sabaeus Vero IC50 28000.0 nM 10.1021/jm00089a007
Chlorocebus sabaeus Vero IC50 28000.0 nM 10.1021/jm020246+
Chlorocebus sabaeus Vero IC50 28000.0 nM 10.1021/jm050096d
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1016/0960-894X(96)00210-7
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1016/j.bmcl.2004.02.031
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1021/jm00042a011
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1021/jm010256v
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1021/jm010418n
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1021/jm050912h
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1021/jm970275y
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1021/jm980510s
Chlorocebus sabaeus Vero IC50 29000.0 nM 10.1021/jm980651u
Chlorocebus sabaeus Vero IC50 50000.0 nM 10.1016/j.bmc.2006.11.026
Chlorocebus sabaeus Vero IC50 50600.0 nM 10.1016/j.bmc.2006.10.043
Chlorocebus sabaeus Vero IC50 50600.0 nM 10.1016/j.bmc.2008.10.078
Chlorocebus sabaeus Vero IC50 50600.0 nM 10.1016/j.bmcl.2009.11.031
Chlorocebus sabaeus Vero IC50 50600.0 nM 10.1016/j.ejmech.2011.05.051
Chlorocebus sabaeus Vero IC50 56000.0 nM 10.1007/s00044-011-9912-x
Chlorocebus sabaeus Vero IC50 56000.0 nM 10.1016/j.bmc.2012.09.026
Chlorocebus sabaeus Vero IC50 56000.0 nM 10.1016/j.bmcl.2011.09.089
Chlorocebus sabaeus Vero IC50 56000.0 nM 10.1016/j.bmcl.2013.09.009
Chlorocebus sabaeus Vero IC50 56000.0 nM 10.1016/j.bmcl.2015.01.007
Chlorocebus sabaeus Vero IC50 100000.0 nM 10.1016/j.ejmech.2011.05.051
Chlorocebus sabaeus Vero IC50 100000.0 nM 10.1021/jm00070a006
Chlorocebus sabaeus Vero MCC nan None 10.1016/j.bmc.2015.12.008
Cryptococcus neoformans Cryptococcus neoformans IC50 nan ug.mL-1 10.1021/jm030475b
Cryptococcus neoformans Cryptococcus neoformans IC50 nan None 10.1021/np0601399
Cryptococcus neoformans Cryptococcus neoformans MIC 10000.0 nM 10.6019/CHEMBL4513141
Dengue virus Dengue virus Inhibition 0.0 % 10.1021/acs.jmedchem.5b00327
Drosophila melanogaster Deoxynucleoside kinase Activity 1054.0 microM/min/mg 10.1016/j.bmcl.2009.12.097
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00081-07
Escherichia coli Escherichia coli MIC 10.0 nM 10.1128/aac.00081-07
Escherichia coli Escherichia coli MIC 10.0 ug.mL-1 10.1021/acs.jmedchem.6b00325
Escherichia coli Escherichia coli MIC 31.6 nM 10.1128/aac.00081-07
Escherichia coli Escherichia coli MIC 5000.0 nM 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC 10000.0 nM 10.1128/aac.00081-07
Escherichia coli K-12 Thymidine phosphorylase Phosphorolysis 0.0 % 10.1021/jm00051a006
Feline immunodeficiency virus Feline immunodeficiency virus EC50 5300.0 nM 10.1016/j.bmc.2019.07.047
Feline immunodeficiency virus Feline immunodeficiency virus EC50 5310.0 nM 10.1016/j.bmcl.2014.04.073
Feline immunodeficiency virus Feline immunodeficiency virus EC50 5310.0 nM 10.1016/j.bmcl.2014.12.047
Feline leukemia virus Feline leukemia virus ED50 0.1 uM 10.1021/np50082a020
Hepacivirus hominis Hepatitis C virus EC50 10000.0 nM 10.1016/j.bmcl.2011.09.089
Hepacivirus hominis Hepatitis C virus EC50 10000.0 nM 10.1016/j.bmcl.2013.03.077
Hepacivirus hominis Hepatitis C virus EC90 10.0 uM 10.1016/j.bmcl.2011.09.089
Hepacivirus hominis Hepatitis C virus EC90 10.0 uM 10.1016/j.bmcl.2013.03.077
Hepacivirus hominis Hepatitis C virus Inhibition nan % 10.1016/j.bmc.2012.09.026
Hepatitis B virus Hepatitis B virus EC50 10000.0 nM 10.1016/j.bmc.2014.10.003
Hepatitis B virus Hepatitis B virus EC50 10000.0 nM 10.1016/j.ejmech.2011.05.051
Hepatitis B virus Hepatitis B virus EC50 10000.0 nM 10.1021/jm970275y
Hepatitis B virus Hepatitis B virus EC50 10000.0 nM 10.1021/jm980651u
Hepatitis B virus Hepatitis B virus EC50 100000.0 nM 10.1016/j.ejmech.2011.05.051
Hepatitis B virus Hepatitis B virus EC90 10.0 uM 10.1016/j.bmc.2014.10.003
Homo sapiens 143B IC50 12250.0 nM 10.1016/j.bmc.2014.09.046
Homo sapiens 143B IC50 148420.0 nM 10.1016/j.bmc.2014.09.046
Homo sapiens 143B Ratio IC50 12.1 None 10.1016/j.bmc.2014.09.046
Homo sapiens 5637 Activity 7.74 % 10.1021/jm5015296
Homo sapiens 5637 Activity nan None 10.1021/jm5015296
Homo sapiens 5637 GI 50.0 % 10.1021/jm5015296
Homo sapiens 5637 IC50 7000.0 nM 10.1021/jm5015296
Homo sapiens 5637 IC50 128820.0 nM 10.1039/C6MD00640J
Homo sapiens 5637 Ratio 0.25 None 10.1021/jm5015296
Homo sapiens 5637 Ratio 1.0 None 10.1021/jm5015296
Homo sapiens A549 IC50 11860.0 nM 10.1016/j.bmcl.2019.08.003
Homo sapiens A549 IC50 16190.0 nM 10.1016/j.bmcl.2015.04.018
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACH-2 cell line p24 125.0 pg ml-1 10.1021/jm00016a002
Homo sapiens ACH-2 cell line p24 155.0 pg ml-1 10.1021/jm00016a002
Homo sapiens ACH-2 cell line p24 167.0 pg ml-1 10.1021/jm00016a002
Homo sapiens ACH-2 cell line p24 289.0 pg ml-1 10.1021/jm00016a002
Homo sapiens ACH-2 cell line p24 19814.0 pg ml-1 10.1021/jm00016a002
Homo sapiens ACH-2 cell line p24 30758.0 pg ml-1 10.1021/jm00016a002
Homo sapiens ACH-2 cell line p24 31360.0 pg ml-1 10.1021/jm00016a002
Homo sapiens ACH-2 cell line p24 31808.0 pg ml-1 10.1021/jm00016a002
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adrenergic receptor beta Activity -4.34 None 10.1016/S0960-894X(97)00046-2
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens ATH-8 cell line CD50 20.0 uM 10.1021/jm00109a012
Homo sapiens ATH-8 cell line ED50 2.4 uM 10.1021/jm00391a003
Homo sapiens ATH-8 cell line ED50 5.0 uM 10.1021/jm00109a012
Homo sapiens ATH-8 cell line ED50 nan None 10.1021/jm00109a012
Homo sapiens ATH-8 cell line ED90 0.25 ug ml-1 10.1021/jm00123a019
Homo sapiens ATH-8 cell line IC50 400.0 nM 10.1016/s0960-894x(99)00324-8
Homo sapiens ATH-8 cell line ID50 45.0 uM 10.1021/jm00391a003
Homo sapiens ATH-8 cell line MIC 1000.0 nM 10.1021/jm00159a001
Homo sapiens ATH-8 cell line Ratio 4.0 None 10.1021/jm00109a012
Homo sapiens ATH-8 cell line SI 50.0 None 10.1021/jm00159a001
Homo sapiens ATPase family AAA domain-containing protein 2 Kd nan None 10.1039/C4MD00237G
Homo sapiens ATP-binding cassette sub-family G member 2 Activity nan None 10.1124/mol.63.1.65
Homo sapiens ATP-binding cassette sub-family G member 2 Inhibition nan % 10.1016/j.bmc.2017.07.001
Homo sapiens Bel-7402 EC50 4620.0 nM 10.1016/j.ejmech.2008.01.011
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile acid receptor FXR Potency 1.3 nM None
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens C8166 CC50 100.0 ug.mL-1 10.1016/j.bmc.2009.05.049
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np0503303
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np060047j
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np0700927
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np0704396
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np300395m
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np300727f
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np300745q
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np900292e
Homo sapiens C8166 CC50 200.0 ug.mL-1 10.1021/np900849y
Homo sapiens C8166 CC50 1000.0 nM 10.1021/jm050257d
Homo sapiens C8166 CC50 1139.47 ug.mL-1 10.1016/j.bmcl.2010.04.132
Homo sapiens C8166 CC50 1145.0 ug.mL-1 10.1016/j.bmcl.2010.06.056
Homo sapiens C8166 CC50 4070.0 nM 10.1021/np200058c
Homo sapiens C8166 CC50 4070.0 nM 10.1021/np200087d
Homo sapiens C8166 CC50 200000.0 nM 10.1021/np400070x
Homo sapiens C8166 CC50 500000.0 nM 10.1021/jm9507338
Homo sapiens C8166 CC50 749000.0 nM 10.1016/j.bmcl.2008.02.040
Homo sapiens C8166 CC50 1000000.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens C8166 CC50 1000000.0 nM 10.1016/0960-894X(96)00444-1
Homo sapiens C8166 CC50 1000000.0 nM 10.1016/0960-894X(96)00446-5
Homo sapiens C8166 CC50 1000000.0 nM 10.1021/np900123z
Homo sapiens C8166 CC50 1400000.0 nM 10.1016/0960-894X(95)00257-T
Homo sapiens C8166 CC50 3987580.0 nM 10.1021/acs.jnatprod.1c00896
Homo sapiens C8166 CC50 4071900.0 nM 10.1021/np200146x
Homo sapiens C8166 CC50 4107390.0 nM 10.1021/jm301226a
Homo sapiens C8166 CC50 4552100.0 nM 10.1021/np0605236
Homo sapiens C8166 CC50 4676070.0 nM 10.1016/j.bmc.2016.03.043
Homo sapiens C8166 CC50 4690000.0 nM 10.1021/acs.jnatprod.5b00392
Homo sapiens C8166 CC50 4913800.0 nM 10.1016/j.ejmech.2012.03.032
Homo sapiens C8166 CC50 5091000.0 nM 10.1021/np070479+
Homo sapiens C8166 CC50 5092000.0 nM 10.1016/j.bmcl.2007.06.008
Homo sapiens C8166 CC50 5110000.0 nM 10.1016/j.bmcl.2012.09.070
Homo sapiens C8166 CC50 5231600.0 nM 10.1021/acs.jnatprod.8b00243
Homo sapiens C8166 CC50 5401400.0 nM 10.1016/j.bmc.2011.06.007
Homo sapiens C8166 CC50 5401400.0 nM 10.1016/j.bmc.2011.07.003
Homo sapiens C8166 CC50 5601710.0 nM 10.1016/j.bmc.2011.05.060
Homo sapiens C8166 CC50 5746100.0 nM 10.1021/np0603166
Homo sapiens C8166 CD50 1000.0 uM 10.1021/jm00170a015
Homo sapiens C8166 EC50 6.0 nM 10.1021/jm9507338
Homo sapiens C8166 EC50 15.0 nM 10.1021/jm960802y
Homo sapiens C8166 EC50 16.0 nM 10.1016/0960-894X(95)00203-6
Homo sapiens C8166 EC50 16.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens C8166 EC50 16.0 nM 10.1016/0960-894X(96)00444-1
Homo sapiens C8166 EC50 16.0 nM 10.1016/0960-894X(96)00446-5
Homo sapiens C8166 EC50 16.0 nM 10.1016/S0960-894X(97)00022-X
Homo sapiens C8166 EC50 20.0 nM 10.1021/jm00076a005
Homo sapiens C8166 EC50 30.0 nM 10.1016/0960-894X(95)00208-B
Homo sapiens C8166 EC50 30.0 nM 10.1021/jm00076a005
Homo sapiens C8166 EC50 40.0 nM 10.1016/0960-894X(95)00585-H
Homo sapiens C8166 ED50 0.01 uM 10.1016/S0960-894X(00)80316-9
Homo sapiens C8166 ED90 0.003 uM 10.1021/jm00083a017
Homo sapiens C8166 ED90 0.1 ug ml-1 10.1021/jm00123a019
Homo sapiens C8166 ED90 1.0 ug ml-1 10.1021/jm00123a019
Homo sapiens C8166 IC50 4.0 nM 10.1016/0960-894X(95)00257-T
Homo sapiens C8166 IC50 8.5 nM 10.1021/jm00170a015
Homo sapiens C8166 IC50 1565.72 ug.mL-1 10.1016/j.ejmech.2019.111566
Homo sapiens C8166 IC50 100000.0 nM 10.1021/jm0010365
Homo sapiens C8166 Selectivity index 350000.0 None 10.1016/0960-894X(95)00257-T
Homo sapiens C8166 SI 25000.0 None 10.1021/jm9903390
Homo sapiens C8166 TC50 1.0 uM 10.1021/jm801395v
Homo sapiens C8166 TC50 1000.0 ug ml-1 10.1021/np000518g
Homo sapiens C8166 TC50 1000.0 ug ml-1 10.1021/np50086a006
Homo sapiens C8166 TC50 1000.0 uM 10.1016/0960-894X(95)00203-6
Homo sapiens C8166 TC50 1000.0 uM 10.1016/S0960-894X(97)00022-X
Homo sapiens C8166 TD50 200.0 uM 10.1016/S0960-894X(00)80316-9
Homo sapiens Caco-2 CC50 56100.0 nM 10.1016/j.ejmech.2007.04.001
Homo sapiens Caco-2 CC50 56100.0 nM 10.1016/j.ejmech.2007.10.014
Homo sapiens Caco-2 IC50 15.0 ug.mL-1 10.1016/j.bmc.2006.10.033
Homo sapiens Caco-2 logPapp -5.55 None 10.1016/j.bmc.2011.08.069
Homo sapiens Caco-2 logPapp -5.16 None 10.1016/j.bmc.2009.08.022
Homo sapiens Caco-2 logPapp -4.84 None 10.1016/j.bmc.2011.03.011
Homo sapiens Caco-2 Papp 2.85 10'-6 cm/s 10.1016/j.bmc.2011.08.069
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 103.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM Activity 2.4 None 10.1128/aac.00277-07
Homo sapiens CCRF-CEM Activity 4.98 uM 10.1016/j.bmcl.2010.06.052
Homo sapiens CCRF-CEM Activity 9.0 % 10.1128/aac.00277-07
Homo sapiens CCRF-CEM Activity 10.0 % 10.1128/aac.00277-07
Homo sapiens CCRF-CEM Activity 11.0 % 10.1128/aac.00277-07
Homo sapiens CCRF-CEM Activity 16.0 % 10.1128/aac.00277-07
Homo sapiens CCRF-CEM Activity 18.0 pmol 10.1128/aac.00692-07
Homo sapiens CCRF-CEM Activity 26.0 % 10.1128/aac.00277-07
Homo sapiens CCRF-CEM Activity 90.0 pmol 10.1128/aac.00692-07
Homo sapiens CCRF-CEM Activity nan None 10.1128/aac.00692-07
Homo sapiens CCRF-CEM Amount 810.9 pM (10e6*cells)-1 10.1021/jm000110g
Homo sapiens CCRF-CEM CC50 35.6 ug.mL-1 10.1021/jm9705869
Homo sapiens CCRF-CEM CC50 100.0 ug.mL-1 10.1021/jm960500w
Homo sapiens CCRF-CEM CC50 125.0 ug.mL-1 10.1021/jm9507901
Homo sapiens CCRF-CEM CC50 1000.0 nM 10.1021/jm000996o
Homo sapiens CCRF-CEM CC50 6000.0 nM 10.1016/s0960-894x(01)00635-7
Homo sapiens CCRF-CEM CC50 14000.0 nM 10.1016/j.bmc.2014.10.003
Homo sapiens CCRF-CEM CC50 14300.0 nM 10.1016/0960-894X(95)00302-A
Homo sapiens CCRF-CEM CC50 14300.0 nM 10.1016/j.bmcl.2013.03.077
Homo sapiens CCRF-CEM CC50 23040.0 nM 10.1016/j.bmcl.2010.06.052
Homo sapiens CCRF-CEM CC50 24000.0 nM 10.1016/j.bmc.2010.03.015
Homo sapiens CCRF-CEM CC50 24060.0 nM 10.1016/j.bmc.2010.01.023
Homo sapiens CCRF-CEM CC50 24060.0 nM 10.1016/j.ejmech.2011.01.016
Homo sapiens CCRF-CEM CC50 24100.0 nM 10.1016/j.bmc.2010.12.031
Homo sapiens CCRF-CEM CC50 56100.0 nM 10.1016/j.ejmech.2015.09.015
Homo sapiens CCRF-CEM CC50 86200.0 nM 10.1128/aac.00392-09
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1016/0960-894X(96)00195-3
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1016/0960-894X(96)00433-7
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1016/j.bmc.2008.06.024
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1016/s0960-894x(98)00158-9
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1016/s0960-894x(98)00535-6
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/acs.jmedchem.0c00358
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/jm000996o
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/jm021016y
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/jm0504306
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/jm950777g
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/jm970664s
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/jm981096z
Homo sapiens CCRF-CEM CC50 250000.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens CCRF-CEM CC50 250000.0 nM 10.1016/0960-894X(96)00444-1
Homo sapiens CCRF-CEM CC50 250000.0 nM 10.1016/j.ejmech.2013.09.047
Homo sapiens CCRF-CEM CC50 500000.0 nM 10.1021/jm00001a001
Homo sapiens CCRF-CEM CC50 500000.0 nM 10.1021/jm00060a013
Homo sapiens CCRF-CEM CC50 500000.0 nM 10.1021/jm001121c
Homo sapiens CCRF-CEM CC50 500000.0 nM 10.1021/jm950605j
Homo sapiens CCRF-CEM CC50 14300000.0 nM 10.1021/jm960694f
Homo sapiens CCRF-CEM CD50 22.0 uM 10.1021/jm00110a011
Homo sapiens CCRF-CEM CD50 23.0 uM 10.1021/jm00110a011
Homo sapiens CCRF-CEM CD50 26.0 uM 10.1021/jm00110a011
Homo sapiens CCRF-CEM Cytotoxicity 14.3 uM 10.1021/jm000110g
Homo sapiens CCRF-CEM Drug uptake 4349.0 pmol 10.1128/aac.00277-07
Homo sapiens CCRF-CEM EC50 0.0007 ug.mL-1 10.1021/jm960500w
Homo sapiens CCRF-CEM EC50 0.0009 ug.mL-1 10.1021/jm960500w
Homo sapiens CCRF-CEM EC50 0.32 nM 10.1021/jm00163a043
Homo sapiens CCRF-CEM EC50 1.0 nM 10.1021/jm000260r
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1016/0960-894X(94)80009-X
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1016/0960-894X(96)00444-1
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1021/jm00047a013
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1021/jm00050a015
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1021/jm00060a013
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1021/jm000996o
Homo sapiens CCRF-CEM EC50 3.0 nM 10.1021/jm950605j
Homo sapiens CCRF-CEM EC50 3.5 nM 10.1016/0960-894X(94)80009-X
Homo sapiens CCRF-CEM EC50 4.0 nM 10.1021/jm00050a015
Homo sapiens CCRF-CEM EC50 4.0 nM 10.1021/jm00060a013
Homo sapiens CCRF-CEM EC50 4.0 nM 10.1021/jm950605j
Homo sapiens CCRF-CEM EC50 4.0 nM 10.1021/jm950777g
Homo sapiens CCRF-CEM EC50 5.0 nM 10.1016/0960-894X(96)00195-3
Homo sapiens CCRF-CEM EC50 5.0 nM 10.1016/0960-894X(96)00433-7
Homo sapiens CCRF-CEM EC50 6.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens CCRF-CEM EC50 6.0 nM 10.1016/0960-894X(96)00444-1
Homo sapiens CCRF-CEM EC50 6.0 nM 10.1021/jm001121c
Homo sapiens CCRF-CEM EC50 6.0 nM 10.1021/jm950777g
Homo sapiens CCRF-CEM EC50 6.0 nM 10.1021/jm970664s
Homo sapiens CCRF-CEM EC50 6.4 nM 10.1021/jm001121c
Homo sapiens CCRF-CEM EC50 7.0 nM 10.1021/jm970664s
Homo sapiens CCRF-CEM EC50 8.0 nM 10.1016/0960-894X(96)00195-3
Homo sapiens CCRF-CEM EC50 8.0 nM 10.1016/0960-894X(96)00433-7
Homo sapiens CCRF-CEM EC50 23.0 nM 10.1021/jm950797i
Homo sapiens CCRF-CEM EC50 186.0 nM 10.1021/jm950620o
Homo sapiens CCRF-CEM EC50 700.0 nM 10.1016/j.ejmech.2010.05.060
Homo sapiens CCRF-CEM EC50 100000.0 nM 10.1016/0960-894X(94)80009-X
Homo sapiens CCRF-CEM EC50 100000.0 nM 10.1016/0960-894X(96)00195-3
Homo sapiens CCRF-CEM EC50 100000.0 nM 10.1016/s0960-894x(98)00158-9
Homo sapiens CCRF-CEM EC50 100000.0 nM 10.1021/jm00060a013
Homo sapiens CCRF-CEM EC50 100000.0 nM 10.1021/jm000996o
Homo sapiens CCRF-CEM EC50 100000.0 nM 10.1021/jm021016y
Homo sapiens CCRF-CEM EC50 100000.0 nM 10.1021/jm970664s
Homo sapiens CCRF-CEM ED50 0.12 uM 10.1021/jm00110a011
Homo sapiens CCRF-CEM ED50 0.18 uM 10.1021/jm00110a011
Homo sapiens CCRF-CEM ED50 0.45 uM 10.1021/jm00110a011
Homo sapiens CCRF-CEM IC50 0.003 ug.mL-1 10.1021/jm9705869
Homo sapiens CCRF-CEM IC50 0.03 ug.mL-1 10.1021/jm00081a015
Homo sapiens CCRF-CEM IC50 6.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 7.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 8.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 10.0 nM 10.1021/jm00001a001
Homo sapiens CCRF-CEM IC50 14.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 17.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 20.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 40.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 46.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 80.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 82.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 87.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 100.0 nM 10.1021/jm00128a034
Homo sapiens CCRF-CEM IC50 870.0 nM 10.1021/jm010212m
Homo sapiens CCRF-CEM IC50 13000.0 nM 10.1021/jm00042a011
Homo sapiens CCRF-CEM IC50 13000.0 nM 10.1021/jm970275y
Homo sapiens CCRF-CEM IC50 14000.0 nM 10.1016/0960-894X(95)00133-E
Homo sapiens CCRF-CEM IC50 14000.0 nM 10.1016/0960-894X(96)00171-0
Homo sapiens CCRF-CEM IC50 14000.0 nM 10.1016/s0960-894x(98)00278-9
Homo sapiens CCRF-CEM IC50 14200.0 nM 10.1021/jm000260r
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1007/s00044-011-9912-x
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmc.2006.10.043
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmc.2006.11.026
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmc.2008.10.078
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmc.2012.09.026
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmcl.2009.11.031
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmcl.2011.09.089
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmcl.2013.09.009
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.bmcl.2015.01.007
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1016/j.ejmech.2011.05.051
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1021/jm010256v
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1021/jm010418n
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1021/jm020246+
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1021/jm050096d
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1021/jm050912h
Homo sapiens CCRF-CEM IC50 14300.0 nM 10.1021/jm980651u
Homo sapiens CCRF-CEM IC50 29000.0 nM 10.1021/jm020376i
Homo sapiens CCRF-CEM IC50 30900.0 nM 10.1016/j.bmcl.2004.02.031
Homo sapiens CCRF-CEM IC50 30900.0 nM 10.1021/jm00053a004
Homo sapiens CCRF-CEM IC50 30900.0 nM 10.1021/jm980510s
Homo sapiens CCRF-CEM IC50 56100.0 nM 10.1016/j.bmc.2011.01.047
Homo sapiens CCRF-CEM IC50 100000.0 nM 10.1016/j.ejmech.2011.05.051
Homo sapiens CCRF-CEM IC50 100000.0 nM 10.1016/s0960-894x(98)00535-6
Homo sapiens CCRF-CEM IC50 100000.0 nM 10.1021/jm00163a043
Homo sapiens CCRF-CEM IC50 191000.0 nM 10.1021/jm950620o
Homo sapiens CCRF-CEM IC50 301600.0 nM 10.1021/jm950797i
Homo sapiens CCRF-CEM IC50 375000.0 nM 10.1021/jm0256225
Homo sapiens CCRF-CEM IC50 500000.0 nM 10.1021/jm00047a013
Homo sapiens CCRF-CEM IC50 500000.0 nM 10.1021/jm00051a006
Homo sapiens CCRF-CEM ID50 0.03 ug ml-1 10.1021/jm00170a017
Homo sapiens CCRF-CEM ID50 0.08 ug ml-1 10.1021/jm00170a017
Homo sapiens CCRF-CEM ID50 0.1 uM 10.1021/jm00122a029
Homo sapiens CCRF-CEM ID50 0.53 ug ml-1 10.1021/jm00170a017
Homo sapiens CCRF-CEM ID50 50.0 ug ml-1 10.1021/jm00166a019
Homo sapiens CCRF-CEM MNCC 5.0 uM 10.1016/j.bmc.2010.12.031
Homo sapiens CCRF-CEM MNTD 5.0 uM 10.1016/j.bmc.2010.01.023
Homo sapiens CCRF-CEM p24 synthesis 32.0 ng ml-1 10.1021/jm00163a004
Homo sapiens CCRF-CEM Reduction 99.96 % 10.1021/jm00163a004
Homo sapiens CCRF-CEM Reduction nan None 10.1016/s0960-894x(99)00581-8
Homo sapiens CCRF-CEM Selectivity index 49.0 None 10.1021/jm00110a011
Homo sapiens CCRF-CEM Selectivity index 144.0 None 10.1021/jm00110a011
Homo sapiens CCRF-CEM Selectivity index 192.0 None 10.1021/jm00110a011
Homo sapiens CCRF-CEM Selectivity index 217.0 None 10.1021/jm00110a011
Homo sapiens CCRF-CEM Selectivity index 220.0 None 10.1021/jm9607921
Homo sapiens CCRF-CEM Stability 0.14 pmol 10.1128/aac.00692-07
Homo sapiens CCRF-CEM Stability 1.56 % 10.1128/aac.00692-07
Homo sapiens CCRF-CEM Stability 2.33 pmol 10.1128/aac.00692-07
Homo sapiens CCRF-CEM Stability 47.0 % 10.1128/aac.00692-07
Homo sapiens CCRF-CEM T1/2 1.4 hr 10.1128/aac.00277-07
Homo sapiens CCRF-CEM T1/2 1.6 hr 10.1128/aac.00277-07
Homo sapiens CCRF-CEM T1/2 2.8 hr 10.1128/aac.00277-07
Homo sapiens CCRF-CEM TAI 93.0 None 10.1021/jm00081a015
Homo sapiens CCRF-CEM TC25 10.0 ug ml-1 10.1021/jm00081a015
Homo sapiens CCRF-CEM TCID50 3.0 ug ml-1 10.1021/jm00170a017
Homo sapiens CCRF-CEM TCID50 29.0 uM 10.1021/jm00122a029
Homo sapiens CCRF-CEM TCID50 29.0 uM 10.1021/jm00128a034
Homo sapiens CEM-c113 CC50 5000.0 nM 10.1021/jm9600095
Homo sapiens CEM-c113 EC50 6.0 nM 10.1021/jm00059a006
Homo sapiens CEM-c113 IC50 20000.0 nM 10.1021/jm00059a006
Homo sapiens CEM-SS CC50 100.0 nM 10.1016/j.bmc.2016.05.010
Homo sapiens CEM-SS CC50 1000.0 nM 10.1016/j.bmc.2010.09.070
Homo sapiens CEM-SS CC50 1000.0 nM 10.1021/jm401232v
Homo sapiens CEM-SS CC50 1000.0 nM 10.1021/jm901758f
Homo sapiens CEM-SS CC50 1000.0 nM 10.1021/jm9607921
Homo sapiens CEM-SS CC50 10000.0 nM 10.1016/0960-894X(95)00584-G
Homo sapiens CEM-SS CC50 100000.0 nM 10.1016/j.bmc.2008.06.024
Homo sapiens CEM-SS CC50 100000.0 nM 10.1016/j.bmc.2009.11.016
Homo sapiens CEM-SS CC50 100000.0 nM 10.1016/s0960-894x(01)00299-2
Homo sapiens CEM-SS CC50 100000.0 nM 10.1016/s0960-894x(98)00535-6
Homo sapiens CEM-SS CC50 100000.0 nM 10.1021/jm00020a007
Homo sapiens CEM-SS CC50 100000.0 nM 10.1021/jm00023a007
Homo sapiens CEM-SS CC50 100000.0 nM 10.1021/jm0009437
Homo sapiens CEM-SS CC50 100000.0 nM 10.1021/jm021016y
Homo sapiens CEM-SS CC50 100000.0 nM 10.1021/jm0308444
Homo sapiens CEM-SS CC50 1000000.0 nM 10.1016/j.ejmech.2021.113315
Homo sapiens CEM-SS Control 3.0 % 10.1021/jm980531m
Homo sapiens CEM-SS Control 5.0 % 10.1021/jm980531m
Homo sapiens CEM-SS Control 35.0 % 10.1021/jm980531m
Homo sapiens CEM-SS Control 114.0 % 10.1021/jm980531m
Homo sapiens CEM-SS Control 119.0 % 10.1021/jm980531m
Homo sapiens CEM-SS Control 121.0 % 10.1021/jm980531m
Homo sapiens CEM-SS EC50 1.9 nM 10.1021/jm0010365
Homo sapiens CEM-SS EC50 1.9 nM 10.1021/jm950702c
Homo sapiens CEM-SS EC50 3.0 nM 10.1021/jm021016y
Homo sapiens CEM-SS EC50 3.8 nM 10.1021/jm9900624
Homo sapiens CEM-SS EC50 4.0 nM 10.1021/jm00045a008
Homo sapiens CEM-SS EC50 6.0 nM 10.1021/jm00020a007
Homo sapiens CEM-SS EC50 6.3 nM 10.1016/j.bmcl.2003.10.036
Homo sapiens CEM-SS EC50 11.0 nM 10.1016/s0960-894x(99)00089-x
Homo sapiens CEM-SS EC50 20.0 nM 10.1016/0960-894X(95)00260-Z
Homo sapiens CEM-SS EC50 95.0 nM 10.1021/jm00045a008
Homo sapiens CEM-SS EC50 300.0 nM 10.1016/0960-894X(95)00260-Z
Homo sapiens CEM-SS EC50 100000.0 nM 10.1016/s0960-894x(01)00299-2
Homo sapiens CEM-SS EC50 nan nM 10.1021/jm991125l
Homo sapiens CEM-SS IC50 2.0 nM 10.1021/jm00017a009
Homo sapiens CEM-SS IC50 2.6 nM 10.1021/jm970559i
Homo sapiens CEM-SS IC50 3.0 nM 10.1021/jm00017a009
Homo sapiens CEM-SS IC50 3.0 nM 10.1021/jm0009437
Homo sapiens CEM-SS IC50 4.0 nM 10.1021/jm00017a009
Homo sapiens CEM-SS IC50 5.0 nM 10.1021/jm00017a009
Homo sapiens CEM-SS IC50 6.0 nM 10.1016/s0960-894x(98)00535-6
Homo sapiens CEM-SS IC50 30.0 nM 10.1021/jm00017a009
Homo sapiens CEM-SS IC50 100.0 nM 10.1128/aac.01443-09
Homo sapiens CEM-SS IC50 1000.0 nM 10.1021/jm00017a009
Homo sapiens CEM-SS IC50 1000.0 nM 10.1021/jm0010365
Homo sapiens CEM-SS IC50 1000.0 nM 10.1021/jm950702c
Homo sapiens CEM-SS IC50 1000.0 nM 10.1021/jm9900624
Homo sapiens CEM-SS IC50 1900.0 nM 10.1021/jm970559i
Homo sapiens CEM-SS IC50 3000.0 nM 10.1016/0960-894X(95)00584-G
Homo sapiens CEM-SS IC50 1887000.0 nM 10.1016/0960-894X(95)00260-Z
Homo sapiens CEM-SS IC50 nan nM 10.1021/jm9705723
Homo sapiens CEM-SS Relative Potency 1.0 None 10.1016/s0960-894x(99)00089-x
Homo sapiens CEM-SS Specific index 33333.0 None 10.1021/jm00023a007
Homo sapiens CEM-SS TC50 0.5 uM 10.1128/aac.01448-09
Homo sapiens CEM-SS TC50 500.0 nM 10.1016/j.bmcl.2012.07.037
Homo sapiens CEM-TK(+) CC50 100000.0 nM 10.1021/jm00020a007
Homo sapiens CEM-TK(+) CC50 100000.0 nM 10.1021/jm0308444
Homo sapiens CEM-TK(+) EC50 100000.0 nM 10.1021/jm00020a007
Homo sapiens CEM-TK(+) EC50 100000.0 nM 10.1021/jm950605j
Homo sapiens CEM-TK(+) EC50 100000.0 nM 10.1021/jm950777g
Homo sapiens CEM-TK(+) EC50 250000.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens CEM-TK(+) EC50 250000.0 nM 10.1016/0960-894X(96)00444-1
Homo sapiens CEM-TK(-) CC50 200.0 ug.mL-1 10.1021/jm960500w
Homo sapiens CEM-TK(-) CC50 1000000.0 nM 10.1016/j.ejmech.2021.113315
Homo sapiens CEM-TK(-) EC50 25.0 ug.mL-1 10.1021/jm960500w
Homo sapiens CEM-TK(-) EC50 100000.0 nM 10.1021/jm001121c
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens C-X-C chemokine receptor type 4 EC50 nan None 10.1016/j.bmcl.2010.07.106
Homo sapiens C-X-C chemokine receptor type 4 IC50 nan nM 10.1016/s0960-894x(01)00323-7
Homo sapiens C-X-C chemokine receptor type 4 IC50 nan nM 10.1016/s0960-894x(02)00041-0
Homo sapiens C-X-C chemokine receptor type 4 Inhibition nan % 10.1016/j.bmcl.2012.04.032
Homo sapiens C-X-C chemokine receptor type 4 Inhibition nan % 10.1021/acsmedchemlett.5b00036
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cyclophilin A Ki nan None 10.1128/aac.01324-07
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA polymerase beta IC50 20000.0 nM 10.1021/np50121a006
Homo sapiens DNA polymerase iota Potency 89125.1 nM None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens DU-145 IC50 34450.0 nM 10.1016/j.bmcl.2015.04.018
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 3662.6 nM None
Homo sapiens Geminin Potency 7307.8 nM None
Homo sapiens Geminin Potency 29855.4 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens H9 CC100 1200.0 uM 10.1021/jm00086a013
Homo sapiens H9 CC25 44.0 uM 10.1021/jm00086a013
Homo sapiens H9 CC50 200000.0 nM 10.1021/jm00001a001
Homo sapiens H9 CC50 1873000.0 nM 10.1021/jm1002952
Homo sapiens H9 EC50 0.002 ug.mL-1 10.1021/np9601667
Homo sapiens H9 EC50 0.01 ug.mL-1 10.1016/s0960-894x(01)00647-3
Homo sapiens H9 EC50 0.012 ug.mL-1 10.1016/s0960-894x(98)00708-2
Homo sapiens H9 EC50 0.012 ug.mL-1 10.1021/np9800710
Homo sapiens H9 EC50 0.0221 ug.mL-1 10.1016/s0960-894x(03)00197-5
Homo sapiens H9 EC50 9.0 nM 10.1016/S0960-894X(97)10108-1
Homo sapiens H9 EC50 10.0 nM 10.1016/j.bmc.2010.08.031
Homo sapiens H9 EC50 15.0 nM 10.1016/s0960-894x(98)00202-9
Homo sapiens H9 EC50 15.0 nM 10.1021/jm980391g
Homo sapiens H9 EC50 37.0 nM 10.1021/jm980391g
Homo sapiens H9 EC50 40.0 nM 10.1016/S0960-894X(01)81071-4
Homo sapiens H9 EC50 45.0 nM 10.1016/s0960-894x(00)00126-8
Homo sapiens H9 EC50 45.0 nM 10.1016/s0960-894x(00)00635-1
Homo sapiens H9 EC50 45.0 nM 10.1016/s0960-894x(01)00437-1
Homo sapiens H9 EC50 45.0 nM 10.1016/s0960-894x(03)00201-4
Homo sapiens H9 EC50 45.0 nM 10.1016/S0960-894X(97)10050-6
Homo sapiens H9 EC50 45.0 nM 10.1016/s0960-894x(98)00254-6
Homo sapiens H9 EC50 45.0 nM 10.1016/s0960-894x(98)00367-9
Homo sapiens H9 EC50 45.0 nM 10.1021/np990633v
Homo sapiens H9 EC50 150.0 nM 10.1016/S0960-894X(01)80161-X
Homo sapiens H9 EC50 150.0 nM 10.1021/jm950922q
Homo sapiens H9 EC50 4500.0 nM 10.1021/jm000070g
Homo sapiens H9 EC50 20000.0 nM 10.1021/jm960802y
Homo sapiens H9 EC50 45000000.0 nM 10.1016/j.bmcl.2004.03.051
Homo sapiens H9 ED50 0.04 ug ml-1 10.1021/jm960008c
Homo sapiens H9 IC50 30.0 nM 10.1021/jm00086a013
Homo sapiens H9 IC50 50.0 nM 10.1016/0960-894X(95)00306-E
Homo sapiens H9 IC50 70.0 nM 10.1021/jm00001a001
Homo sapiens H9 IC50 100.0 nM 10.1128/aac.01443-09
Homo sapiens H9 IC50 500.0 ug.mL-1 10.1016/s0960-894x(01)00647-3
Homo sapiens H9 IC50 500.0 ug.mL-1 10.1016/s0960-894x(03)00197-5
Homo sapiens H9 IC50 500.0 ug.mL-1 10.1016/s0960-894x(98)00708-2
Homo sapiens H9 IC50 500.0 ug.mL-1 10.1021/np010211x
Homo sapiens H9 IC50 500.0 ug.mL-1 10.1021/np060124a
Homo sapiens H9 IC50 500.0 ug.mL-1 10.1021/np970497z
Homo sapiens H9 IC50 500.0 ug.mL-1 10.1021/np990281s
Homo sapiens H9 IC50 1875.0 ug.mL-1 10.1021/np980291d
Homo sapiens H9 IC50 2000.0 ug.mL-1 10.1021/jm960008c
Homo sapiens H9 IC50 150000.0 nM 10.1021/jm00167a034
Homo sapiens H9 IC50 500000.0 nM 10.1016/j.bmcl.2007.05.026
Homo sapiens H9 IC50 500000.0 nM 10.1016/s0960-894x(03)00201-4
Homo sapiens H9 IC50 500000.0 nM 10.1016/S0960-894X(97)10108-1
Homo sapiens H9 IC50 500000.0 nM 10.1016/s0960-894x(98)00202-9
Homo sapiens H9 IC50 500000.0 nM 10.1021/jm980391g
Homo sapiens H9 IC50 1870000.0 nM 10.1021/np060239e
Homo sapiens H9 IC50 1872000.0 nM 10.1016/j.bmcl.2004.09.032
Homo sapiens H9 IC50 1872000.0 nM 10.1021/jm030416y
Homo sapiens H9 IC50 1873000.0 nM 10.1016/j.bmcl.2004.09.033
Homo sapiens H9 IC50 1873000.0 nM 10.1016/s0960-894x(00)00635-1
Homo sapiens H9 IC50 1875000.0 nM 10.1016/j.bmcl.2004.03.051
Homo sapiens H9 IC50 1875000.0 nM 10.1016/s0960-894x(00)00126-8
Homo sapiens H9 IC50 1875000.0 nM 10.1016/s0960-894x(01)00437-1
Homo sapiens H9 IC50 1875000.0 nM 10.1016/S0960-894X(01)80161-X
Homo sapiens H9 IC50 1875000.0 nM 10.1016/S0960-894X(97)10050-6
Homo sapiens H9 IC50 1875000.0 nM 10.1016/s0960-894x(98)00254-6
Homo sapiens H9 IC50 1875000.0 nM 10.1016/s0960-894x(98)00367-9
Homo sapiens H9 IC50 1875000.0 nM 10.1021/jm000070g
Homo sapiens H9 IC50 1875000.0 nM 10.1021/jm950922q
Homo sapiens H9 IC50 1875000.0 nM 10.1021/np0101189
Homo sapiens H9 IC50 1900000.0 nM 10.1016/j.bmc.2006.12.013
Homo sapiens H9 IC50 2000000.0 nM 10.1016/S0960-894X(01)81071-4
Homo sapiens H9 IC50 2000000.0 nM 10.1021/np50103a006
Homo sapiens H9 IC50 2000000.0 nM 10.1021/np50104a008
Homo sapiens H9 IC95 20000.0 nM 10.1021/jm00099a007
Homo sapiens H9 P24 concentration 100.0 ng ml-1 10.1021/jm950822k
Homo sapiens H9 P24 concentration 600.0 ng ml-1 10.1021/jm950822k
Homo sapiens HEK293 CC50 10000.0 nM 10.6019/CHEMBL4513141
Homo sapiens HEL MCC nan None 10.1016/j.bmc.2015.12.008
Homo sapiens HeLa Activity 100.0 % 10.1007/s00044-012-0241-5
Homo sapiens HeLa Activity nan None 10.1021/jm0508890
Homo sapiens HeLa CC50 25000.0 nM 10.1016/j.bmcl.2015.01.058
Homo sapiens HeLa EC50 2.0 nM 10.1021/jm000209n
Homo sapiens HeLa EC50 9.0 nM 10.1021/jm970172f
Homo sapiens HeLa EC50 13.0 nM 10.1021/jm970172f
Homo sapiens HeLa EC50 2900.0 nM 10.1021/jm970172f
Homo sapiens HeLa EC50 374000.0 nM 10.1021/jm201551m
Homo sapiens HeLa IC50 10770.0 nM 10.1016/j.bmcl.2019.08.003
Homo sapiens HeLa IC50 10770.0 nM 10.1021/acs.jmedchem.6b00764
Homo sapiens HeLa IC50 65460.0 nM 10.1016/j.bmcl.2015.04.018
Homo sapiens HeLa IC50 100000.0 nM 10.1016/j.bmc.2012.06.038
Homo sapiens HeLa IC50 100000.0 nM 10.1016/j.bmcl.2007.03.067
Homo sapiens HeLa MCC nan None 10.1016/j.bmc.2015.12.008
Homo sapiens Hepatocyte CL 12.4 mL.min-1.kg-1 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte logCL 1.093 None 10.1016/j.ejmech.2008.07.027
Homo sapiens HepG2 Activity 60.0 % 10.1128/aac.00794-10
Homo sapiens HepG2 Activity 300.0 % 10.1128/aac.00794-10
Homo sapiens HepG2 Activity nan None 10.1016/j.bmcl.2012.11.027
Homo sapiens HepG2 Activity nan None 10.1128/aac.00794-10
Homo sapiens HepG2 CC50 100000.0 nM 10.1016/j.bmc.2014.10.003
Homo sapiens HepG2 IC50 13030.0 nM 10.1016/j.bmcl.2019.08.003
Homo sapiens HepG2 IC50 400000.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HepG2 IC50 479000.0 nM 10.1016/j.bmcl.2014.09.079
Homo sapiens HepG2 IC50 479000.0 nM 10.1016/j.bmcl.2016.05.092
Homo sapiens HepG2 IC50 nan nM 10.1021/jm980510s
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00020a026
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HL-60 IC50 96000.0 nM 10.1021/jm00170a016
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity 1.0 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens AUC 0.85 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens AUC 6.51 ng.hr/ml/mg 10.1128/aac.01209-09
Homo sapiens Homo sapiens AUC 8.77 ng.hr/ml/mg 10.1128/aac.01209-09
Homo sapiens Homo sapiens AUC 9.62 ng.hr/ml/mg 10.1128/aac.01209-09
Homo sapiens Homo sapiens AUC 502.0 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens AUC 627.0 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens AUC 11883.0 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens CC50 12000.0 nM 10.1021/jm00015a008
Homo sapiens Homo sapiens CC50 15000.0 nM 10.1021/jm010863i
Homo sapiens Homo sapiens CC50 83000.0 nM 10.1021/jm00012a002
Homo sapiens Homo sapiens CL 25.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 25.0 mL.min-1.kg-1 10.1124/dmd.110.037457
Homo sapiens Homo sapiens CL 33.3 mL.min-1.kg-1 10.1124/dmd.110.037457
Homo sapiens Homo sapiens CL/F 23.17 mL.min-1.kg-1 10.1128/aac.01209-09
Homo sapiens Homo sapiens CL/F 30.0 mL.min-1.kg-1 10.1128/aac.01209-09
Homo sapiens Homo sapiens CL/F 39.0 mL.min-1.kg-1 10.1128/aac.01209-09
Homo sapiens Homo sapiens CL_renal 5.67 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cmax 4.39e-05 nM 10.1128/aac.01626-06
Homo sapiens Homo sapiens Cmax 6.247e-05 nM 10.1128/aac.01626-06
Homo sapiens Homo sapiens Cmax 0.002998 nM 10.1128/aac.01626-06
Homo sapiens Homo sapiens Cmax 4.34 ng/ml/mg 10.1128/aac.01209-09
Homo sapiens Homo sapiens Cmax 6.74 ng/ml/mg 10.1128/aac.01209-09
Homo sapiens Homo sapiens Cmax 7.58 ng/ml/mg 10.1128/aac.01209-09
Homo sapiens Homo sapiens Cmin 6.26 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Cmin 7.95 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Cmin 38.82 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Concentration 0.69 pM (10e6*cells)-1 10.1021/jm000260r
Homo sapiens Homo sapiens Concentration 1.37 pM (10e6*cells)-1 10.1021/jm000260r
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 8.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Drug uptake 9.3 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Drug uptake 11.5 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Drug uptake 12.2 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Drug uptake 15.4 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Drug uptake 23.5 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Drug uptake 75.3 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens Drug uptake 76.2 fmol 10.1128/aac.01626-06
Homo sapiens Homo sapiens EC50 2.0 nM 10.1021/jm00015a008
Homo sapiens Homo sapiens EC50 3.0 nM 10.1021/jm00012a002
Homo sapiens Homo sapiens EC50 6.0 nM 10.1021/jm000260r
Homo sapiens Homo sapiens EC50 7.0 nM 10.1021/jm000260r
Homo sapiens Homo sapiens EC50 10.0 nM 10.1021/jm000260r
Homo sapiens Homo sapiens EC50 15.0 nM 10.1021/jm000260r
Homo sapiens Homo sapiens EC50 56.0 nM 10.1021/jm010863i
Homo sapiens Homo sapiens EC50 300.0 nM 10.1021/jm000260r
Homo sapiens Homo sapiens EC50 1000.0 nM 10.1021/jm000260r
Homo sapiens Homo sapiens EC50 nan nM 10.1016/0960-894X(95)00133-E
Homo sapiens Homo sapiens F 63.0 % 10.1016/j.bmc.2011.08.069
Homo sapiens Homo sapiens F 64.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens Fabs 90.0 % 10.1124/dmd.110.034629
Homo sapiens Homo sapiens IC100 0.01 uM 10.1021/jm000260r
Homo sapiens Homo sapiens IC50 20.0 nM 10.1021/jm00017a009
Homo sapiens Homo sapiens IC50 400.0 nM 10.1021/jm00017a009
Homo sapiens Homo sapiens IC50 100000.0 nM 10.1021/jm000260r
Homo sapiens Homo sapiens IC50 nan nM 10.1016/0960-894X(95)00133-E
Homo sapiens Homo sapiens Ratio AUC 0.86 None 10.1128/aac.01209-09
Homo sapiens Homo sapiens Ratio AUC 1.04 None 10.1128/aac.01209-09
Homo sapiens Homo sapiens Ratio AUC 1.21 None 10.1128/aac.01209-09
Homo sapiens Homo sapiens T1/2 0.832 hr 10.1124/dmd.110.037457
Homo sapiens Homo sapiens T1/2 2.2 hr 10.1128/aac.01209-09
Homo sapiens Homo sapiens T1/2 2.4 hr 10.1128/aac.01209-09
Homo sapiens Homo sapiens T1/2 2.5 hr 10.1128/aac.01209-09
Homo sapiens Homo sapiens T1/2 5.48 hr 10.1128/aac.01626-06
Homo sapiens Homo sapiens T1/2 6.3 hr 10.1128/aac.01626-06
Homo sapiens Homo sapiens Tmax 0.5 hr 10.1128/aac.01209-09
Homo sapiens Homo sapiens Tmax 2.44 hr 10.1128/aac.01626-06
Homo sapiens Homo sapiens Tmax 3.48 hr 10.1128/aac.01626-06
Homo sapiens Homo sapiens Tmax 4.74 hr 10.1128/aac.01626-06
Homo sapiens Homo sapiens Toxicity 5.04 None 10.1021/jm00170a017
Homo sapiens Homo sapiens Toxicity 23.6 None 10.1021/jm00170a017
Homo sapiens Homo sapiens Toxicity 74.1 None 10.1021/jm00170a017
Homo sapiens Homo sapiens Vdss 1.8 L.kg-1 10.1124/dmd.110.037457
Homo sapiens Huh-7 CC50 10000.0 nM 10.1016/j.bmcl.2011.09.089
Homo sapiens Huh-7 CC50 10000.0 nM 10.1016/j.bmcl.2013.03.077
Homo sapiens Hydroxycarboxylic acid receptor 2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens JM1 CC50 1000000.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens JM1 EC50 200000.0 nM 10.1016/0960-894X(96)00443-X
Homo sapiens JM1 ED50 100.0 uM 10.1016/S0960-894X(00)80395-9
Homo sapiens JM1 TD50 1000.0 uM 10.1016/S0960-894X(00)80395-9
Homo sapiens Jurkat CC50 500000.0 nM 10.1021/jm00001a001
Homo sapiens Jurkat IC50 10.0 nM 10.1021/jm00001a001
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KB IC50 3.12 ug.mL-1 10.1016/j.bmc.2011.08.069
Homo sapiens KB IC50 9770.0 nM 10.1016/j.bmcl.2019.08.003
Homo sapiens KB IC50 9770.0 nM 10.1021/acs.jmedchem.6b00764
Homo sapiens KB IC50 400000.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens KB IC50 479000.0 nM 10.1016/j.bmcl.2014.09.079
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens LNCaP IC50 nan nM 10.1021/jm980510s
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 Amount 2658.4 pM (10e6*cells)-1 10.1021/jm000110g
Homo sapiens MCF7 Cytotoxicity 0.008 uM 10.1021/jm000110g
Homo sapiens MCF7 IC50 2.6 ug.mL-1 10.1016/j.bmc.2011.08.069
Homo sapiens MCF7 IC50 7670.0 nM 10.1021/acs.jmedchem.6b00764
Homo sapiens MCF7 IC50 10000.0 nM 10.1021/jm980510s
Homo sapiens MCF7 IC50 13740.0 nM 10.1016/j.bmc.2014.09.046
Homo sapiens MCF7 IC50 34970.0 nM 10.1016/j.bmcl.2015.04.018
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.bmcl.2020.127365
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Mitochondrial amidoxime-reducing component 1 Activity nan None 10.1021/acs.jmedchem.9b01483
Homo sapiens Mitochondrial amidoxime reducing component 2 Activity nan None 10.1021/acs.jmedchem.9b01483
Homo sapiens MOLT-3 CC50 12100.0 nM 10.1016/j.bmc.2012.03.047
Homo sapiens MOLT-4 EC50 6.2 nM 10.1016/s0960-894x(00)00202-x
Homo sapiens MOLT-4 IC50 62800.0 nM 10.1021/jm001121c
Homo sapiens MOLT-4 IC50 375000.0 nM 10.1021/jm0256225
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MRC5 CD50 72.0 uM 10.1021/jm00062a006
Homo sapiens MT2 CC100 500.0 uM 10.1021/jm00086a013
Homo sapiens MT2 CC25 56.0 uM 10.1021/jm00086a013
Homo sapiens MT2 CC50 10000.0 nM 10.1021/jm00062a027
Homo sapiens MT2 CC50 10000.0 nM 10.1021/jm040093l
Homo sapiens MT2 CC50 10000.0 nM 10.1021/jm0607404
Homo sapiens MT2 CC50 25000.0 nM 10.1016/j.ejmech.2013.02.042
Homo sapiens MT2 CC50 100000.0 nM 10.1021/jm020537i
Homo sapiens MT2 CC50 123000.0 nM 10.1021/jm00033a018
Homo sapiens MT2 CC50 150000.0 nM 10.1128/aac.00392-09
Homo sapiens MT2 CC50 200000.0 nM 10.1016/j.bmc.2007.05.047
Homo sapiens MT2 CC50 200000.0 nM 10.1016/j.bmc.2008.12.028
Homo sapiens MT2 CC50 200000.0 nM 10.1016/j.bmcl.2007.11.125
Homo sapiens MT2 CC50 200000.0 nM 10.1016/j.bmcl.2010.05.090
Homo sapiens MT2 CC50 1870000.0 nM 10.1021/jm900136j
Homo sapiens MT2 CC50 nan None 10.1016/j.bmcl.2010.07.106
Homo sapiens MT2 EC50 3.0 nM 10.1021/jm00045a008
Homo sapiens MT2 EC50 14.0 nM 10.1021/jm950797i
Homo sapiens MT2 EC50 29.0 nM 10.1021/jm950797i
Homo sapiens MT2 EC50 30.0 nM 10.1021/jm030116g
Homo sapiens MT2 EC50 37.0 nM 10.1021/jm950797i
Homo sapiens MT2 EC50 180.0 nM 10.1021/jm00163a043
Homo sapiens MT2 ED50 0.07 uM 10.1021/jm00033a018
Homo sapiens MT2 ED90 0.3 uM 10.1016/S0960-894X(01)80775-7
Homo sapiens MT2 IC50 0.14 ug.mL-1 10.1021/jm00081a015
Homo sapiens MT2 IC50 6.0 nM 10.1021/jm00017a009
Homo sapiens MT2 IC50 27.0 nM 10.1021/jm020537i
Homo sapiens MT2 IC50 160.0 nM 10.1021/jm00086a013
Homo sapiens MT2 IC50 200.0 nM 10.1021/jm00086a013
Homo sapiens MT2 IC50 220.0 nM 10.1021/jm00086a013
Homo sapiens MT2 IC50 10000.0 nM 10.1021/jm00086a013
Homo sapiens MT2 IC50 31000.0 nM 10.1021/jm00086a013
Homo sapiens MT2 IC50 51640.0 nM 10.1021/jm950797i
Homo sapiens MT2 IC50 83440.0 nM 10.1021/jm950797i
Homo sapiens MT2 IC50 119840.0 nM 10.1021/jm950797i
Homo sapiens MT2 IC50 131710.0 nM 10.1021/jm950797i
Homo sapiens MT2 IC50 970000.0 nM 10.1021/jm00163a043
Homo sapiens MT2 IC50 1870000.0 nM 10.1016/j.bmcl.2007.09.081
Homo sapiens MT2 IC50 1870000.0 nM 10.1021/jm901782m
Homo sapiens MT2 IC50 1872000.0 nM 10.1016/j.bmc.2010.04.089
Homo sapiens MT2 TAI 82.0 None 10.1021/jm00081a015
Homo sapiens MT2 TC25 9.3 ug ml-1 10.1021/jm00081a015
Homo sapiens MT4 Antigen p24 content 0.68 ng ml-1 10.1021/jm00042a005
Homo sapiens MT4 Antigen p24 content 0.82 ng ml-1 10.1021/jm00042a005
Homo sapiens MT4 CC50 0.52 ug.mL-1 10.1016/s0960-894x(02)00394-3
Homo sapiens MT4 CC50 1.0 ug.mL-1 10.1016/j.ejmech.2012.04.038
Homo sapiens MT4 CC50 1.5 ug.mL-1 10.1021/jm960500w
Homo sapiens MT4 CC50 1.64 ug.mL-1 10.1016/s0960-894x(03)00730-3
Homo sapiens MT4 CC50 1.9 ug.mL-1 10.1021/np020234r
Homo sapiens MT4 CC50 2.0 ug.mL-1 10.1016/j.ejmech.2016.04.019
Homo sapiens MT4 CC50 2.01 ug.mL-1 10.1016/j.bmc.2008.11.056
Homo sapiens MT4 CC50 2.5 ug.mL-1 10.1007/s00044-011-9664-7
Homo sapiens MT4 CC50 2.581 ug.mL-1 10.1021/np980481o
Homo sapiens MT4 CC50 7.48 nM 10.1021/acs.jmedchem.7b00332
Homo sapiens MT4 CC50 25.0 ug.mL-1 10.1007/s00044-011-9662-9
Homo sapiens MT4 CC50 25.0 ug.mL-1 10.1007/s00044-011-9705-2
Homo sapiens MT4 CC50 25.0 ug.mL-1 10.1007/s00044-011-9776-0
Homo sapiens MT4 CC50 25.0 ug.mL-1 10.1007/s00044-013-0567-7
Homo sapiens MT4 CC50 25.0 ug.mL-1 10.1016/j.bmc.2015.12.008
Homo sapiens MT4 CC50 65.4 ug.mL-1 10.1016/j.bmcl.2011.03.105
Homo sapiens MT4 CC50 100.0 nM 10.1021/acs.jnatprod.5b01012
Homo sapiens MT4 CC50 370.0 nM 10.1021/acs.jnatprod.9b00088
Homo sapiens MT4 CC50 370.0 nM 10.1021/acsmedchemlett.0c00414
Homo sapiens MT4 CC50 400.0 nM 10.1016/j.ejmech.2018.07.020
Homo sapiens MT4 CC50 500.0 nM 10.1021/acs.jmedchem.7b00416
Homo sapiens MT4 CC50 1000.0 nM 10.1021/jm000996o
Homo sapiens MT4 CC50 1000.0 nM 10.1021/jm901758f
Homo sapiens MT4 CC50 2000.0 nM 10.1016/j.ejmech.2018.01.016
Homo sapiens MT4 CC50 2000.0 nM 10.1016/j.ejmech.2021.113868
Homo sapiens MT4 CC50 3200.0 nM 10.1016/0960-894X(96)00355-1
Homo sapiens MT4 CC50 3200.0 nM 10.1021/jm00012a002
Homo sapiens MT4 CC50 3700.0 nM 10.1016/j.bmcl.2006.03.080
Homo sapiens MT4 CC50 3700.0 nM 10.1021/jm050744t
Homo sapiens MT4 CC50 3740.0 nM 10.1021/acs.jnatprod.5b00660
Homo sapiens MT4 CC50 3740.0 nM 10.1021/acs.jnatprod.8b00211
Homo sapiens MT4 CC50 4800.0 nM 10.1021/jm00171a023
Homo sapiens MT4 CC50 6000.0 nM 10.1016/0960-894X(94)80009-X
Homo sapiens MT4 CC50 6000.0 nM 10.1021/jm00050a015
Homo sapiens MT4 CC50 6000.0 nM 10.1021/jm00060a013
Homo sapiens MT4 CC50 6000.0 nM 10.1021/jm950605j
Homo sapiens MT4 CC50 7000.0 nM 10.1016/j.bmcl.2017.03.009
Homo sapiens MT4 CC50 7060.0 nM 10.1016/j.ejmech.2022.114512
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.bmc.2018.03.003
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.bmc.2021.116195
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.bmc.2021.116239
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.bmcl.2020.127287
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.ejmech.2016.02.068
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.ejmech.2017.02.047
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.ejmech.2017.07.012
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.ejmech.2018.03.059
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.ejmech.2020.112811
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.ejmech.2020.113051
Homo sapiens MT4 CC50 7480.0 nM 10.1016/j.ejmech.2022.114471
Homo sapiens MT4 CC50 7480.0 nM 10.1021/acs.jmedchem.5b01183
Homo sapiens MT4 CC50 7480.0 nM 10.1021/acs.jmedchem.8b01729
Homo sapiens MT4 CC50 7480.0 nM 10.1021/acsmedchemlett.8b00054
Homo sapiens MT4 CC50 7484.0 nM 10.1021/acsmedchemlett.7b00361
Homo sapiens MT4 CC50 7490.0 nM 10.1016/j.ejmech.2019.111619
Homo sapiens MT4 CC50 7500.0 nM 10.1016/j.bmc.2016.05.010
Homo sapiens MT4 CC50 7500.0 nM 10.1016/j.bmc.2017.03.009
Homo sapiens MT4 CC50 7500.0 nM 10.1016/j.ejmech.2020.113063
Homo sapiens MT4 CC50 7800.0 nM 10.1021/jm00015a008
Homo sapiens MT4 CC50 7800.0 nM 10.1021/jm00080a020
Homo sapiens MT4 CC50 7800.0 nM 10.1021/jm00103a009
Homo sapiens MT4 CC50 7800.0 nM 10.1021/jm00108a041
Homo sapiens MT4 CC50 9300.0 nM 10.1021/jm00106a040
Homo sapiens MT4 CC50 12000.0 nM 10.1016/s0960-894x(01)00323-7
Homo sapiens MT4 CC50 12000.0 nM 10.1016/s0960-894x(02)00041-0
Homo sapiens MT4 CC50 15000.0 nM 10.1016/j.ejmech.2019.111864
Homo sapiens MT4 CC50 15000.0 nM 10.1021/acs.jnatprod.9b00993
Homo sapiens MT4 CC50 18710.0 nM 10.1021/jm300477h
Homo sapiens MT4 CC50 20000.0 nM 10.1016/s0960-894x(00)00535-7
Homo sapiens MT4 CC50 20000.0 nM 10.1016/S0960-894X(97)00340-5
Homo sapiens MT4 CC50 20000.0 nM 10.1021/jm00017a010
Homo sapiens MT4 CC50 20000.0 nM 10.1021/jm00020a015
Homo sapiens MT4 CC50 20000.0 nM 10.1021/jm00105a055
Homo sapiens MT4 CC50 20000.0 nM 10.1021/jm00108a028
Homo sapiens MT4 CC50 20000.0 nM 10.1021/jm00132a002
Homo sapiens MT4 CC50 20000.0 nM 10.1021/jm950568w
Homo sapiens MT4 CC50 25000.0 nM 10.1021/acs.jnatprod.5b00116
Homo sapiens MT4 CC50 25000.0 nM 10.1021/np500271u
Homo sapiens MT4 CC50 27000.0 nM 10.1016/j.bmc.2015.06.020
Homo sapiens MT4 CC50 30595.0 nM 10.1016/j.ejmech.2014.04.027
Homo sapiens MT4 CC50 30595.0 nM 10.1016/j.ejmech.2020.112696
Homo sapiens MT4 CC50 30595.0 nM 10.1021/acs.jmedchem.6b01906
Homo sapiens MT4 CC50 31000.0 nM 10.1016/j.bmc.2015.06.020
Homo sapiens MT4 CC50 35600.0 nM 10.1016/j.bmc.2007.10.013
Homo sapiens MT4 CC50 35600.0 nM 10.1021/jm9802012
Homo sapiens MT4 CC50 37000.0 nM 10.1021/jm301040s
Homo sapiens MT4 CC50 42000.0 nM 10.1021/jm010863i
Homo sapiens MT4 CC50 42000.0 nM 10.1021/jm010969d
Homo sapiens MT4 CC50 46000.0 nM 10.1016/j.ejmech.2012.04.004
Homo sapiens MT4 CC50 46440.0 nM 10.1016/j.bmc.2011.10.002
Homo sapiens MT4 CC50 49770.0 nM 10.1016/j.bmc.2012.04.030
Homo sapiens MT4 CC50 50000.0 nM 10.1007/s00044-010-9513-0
Homo sapiens MT4 CC50 50000.0 nM 10.1007/s00044-012-0342-1
Homo sapiens MT4 CC50 50000.0 nM 10.1016/j.bmc.2012.07.026
Homo sapiens MT4 CC50 50000.0 nM 10.1021/jm500139a
Homo sapiens MT4 CC50 50000.0 nM 10.1021/jm980358u
Homo sapiens MT4 CC50 57000.0 nM 10.1021/jm049429h
Homo sapiens MT4 CC50 60000.0 nM 10.1016/j.bmc.2009.02.033
Homo sapiens MT4 CC50 61000.0 nM 10.1016/j.bmc.2009.02.011
Homo sapiens MT4 CC50 74000.0 nM 10.1016/j.bmc.2020.115923
Homo sapiens MT4 CC50 75000.0 nM 10.1021/jm00020a007
Homo sapiens MT4 CC50 75000.0 nM 10.1021/jm0308444
Homo sapiens MT4 CC50 77500.0 nM 10.1016/j.ejmech.2019.01.020
Homo sapiens MT4 CC50 80000.0 nM 10.1021/jm00047a011
Homo sapiens MT4 CC50 80000.0 nM 10.1021/jm960802y
Homo sapiens MT4 CC50 88260.0 nM 10.1016/j.ejmech.2011.08.011
Homo sapiens MT4 CC50 93500.0 nM 10.1016/j.bmc.2014.03.020
Homo sapiens MT4 CC50 93500.0 nM 10.1016/j.bmcl.2013.12.093
Homo sapiens MT4 CC50 93548.9 nM 10.1016/j.ejmech.2014.05.059
Homo sapiens MT4 CC50 93550.0 nM 10.1007/s00044-009-9220-x
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmc.2008.01.039
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmc.2009.07.028
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmc.2010.06.067
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmc.2011.05.024
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmc.2011.07.023
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmc.2014.11.032
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmcl.2008.09.055
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.bmcl.2012.09.108
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.ejmech.2009.06.037
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.ejmech.2013.04.052
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.ejmech.2014.02.047
Homo sapiens MT4 CC50 93550.0 nM 10.1016/j.ejmech.2014.09.054
Homo sapiens MT4 CC50 93560.0 nM 10.1016/j.bmc.2013.08.040
Homo sapiens MT4 CC50 93560.0 nM 10.1039/C3MD00247K
Homo sapiens MT4 CC50 93600.0 nM 10.1016/j.bmc.2014.02.030
Homo sapiens MT4 CC50 93630.0 nM 10.1016/j.ejmech.2012.10.036
Homo sapiens MT4 CC50 94000.0 nM 10.1016/j.bmc.2013.10.033
Homo sapiens MT4 CC50 94000.0 nM 10.1016/j.bmc.2015.03.037
Homo sapiens MT4 CC50 94000.0 nM 10.1016/j.ejmech.2015.01.042
Homo sapiens MT4 CC50 94000.0 nM 10.1016/j.ejmech.2015.02.022
Homo sapiens MT4 CC50 99000.0 nM 10.1016/j.bmc.2016.04.010
Homo sapiens MT4 CC50 100000.0 nM 10.1016/j.bmc.2008.06.024
Homo sapiens MT4 CC50 100000.0 nM 10.1016/j.bmc.2009.11.016
Homo sapiens MT4 CC50 100000.0 nM 10.1016/j.bmc.2011.12.055
Homo sapiens MT4 CC50 100000.0 nM 10.1016/j.bmc.2013.06.061
Homo sapiens MT4 CC50 100000.0 nM 10.1016/j.bmc.2015.06.020
Homo sapiens MT4 CC50 100000.0 nM 10.1016/j.bmcl.2012.04.032
Homo sapiens MT4 CC50 100000.0 nM 10.1021/jm000209n
Homo sapiens MT4 CC50 100000.0 nM 10.1021/jm001033s
Homo sapiens MT4 CC50 100000.0 nM 10.1021/jm010969d
Homo sapiens MT4 CC50 100000.0 nM 10.1021/jm021016y
Homo sapiens MT4 CC50 100000.0 nM 10.1021/jm991125l
Homo sapiens MT4 CC50 100000.0 nM 10.1128/aac.00277-07
Homo sapiens MT4 CC50 110000.0 nM 10.1021/jm00001a001
Homo sapiens MT4 CC50 113000.0 nM 10.1016/0960-894X(95)00208-B
Homo sapiens MT4 CC50 113000.0 nM 10.1016/0960-894X(95)00585-H
Homo sapiens MT4 CC50 140000.0 nM 10.1016/j.ejmech.2021.113315
Homo sapiens MT4 CC50 150000.0 nM 10.1021/jm9507338
Homo sapiens MT4 CC50 190000.0 nM 10.1016/s0960-894x(00)00535-7
Homo sapiens MT4 CC50 249000.0 nM 10.1016/j.bmc.2012.09.058
Homo sapiens MT4 CC50 249000.0 nM 10.1016/j.bmcl.2012.09.062
Homo sapiens MT4 CC50 249500.0 nM 10.1016/j.ejmech.2012.02.019
Homo sapiens MT4 CC50 249500.0 nM 10.1039/C3MD00028A
Homo sapiens MT4 CC50 500000.0 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens MT4 CC75 0.37 uM 10.1016/j.bmcl.2021.128319
Homo sapiens MT4 CD50 1.0 ug ml-1 10.1016/S0960-894X(00)80050-5
Homo sapiens MT4 CD50 4.0 uM 10.1021/jm00394a034
Homo sapiens MT4 CD50 4.8 uM 10.1021/jm00128a013
Homo sapiens MT4 CD50 4.81 uM 10.1021/jm00168a046
Homo sapiens MT4 CD50 6.3 uM 10.1021/jm00164a059
Homo sapiens MT4 CD50 20.0 uM 10.1021/jm00096a011
Homo sapiens MT4 CD50 20.0 uM 10.1021/jm00118a033
Homo sapiens MT4 CD50 52.0 uM 10.1021/jm9600499
Homo sapiens MT4 CD50 52.0 uM 10.1021/jm970443m
Homo sapiens MT4 CD50 140.0 uM 10.1021/jm011011l
Homo sapiens MT4 CD50 187.5 uM 10.1021/jm0310176
Homo sapiens MT4 CIC 25.0 nM 10.1021/jm00088a003
Homo sapiens MT4 CTC50 0.0053 M 10.1021/jm00042a005
Homo sapiens MT4 EC50 0.0005 ug.mL-1 10.1016/s0960-894x(02)00394-3
Homo sapiens MT4 EC50 0.0005 ug.mL-1 10.1021/jm960500w
Homo sapiens MT4 EC50 0.0007 ug.mL-1 10.1021/jm960500w
Homo sapiens MT4 EC50 0.0012 ug.mL-1 10.1016/s0960-894x(03)00730-3
Homo sapiens MT4 EC50 0.002 ug.mL-1 10.1021/jm00094a014
Homo sapiens MT4 EC50 0.0032 ug.mL-1 10.1016/0960-894X(95)00395-A
Homo sapiens MT4 EC50 0.01 ug.mL-1 10.1016/s0960-894x(03)00730-3
Homo sapiens MT4 EC50 0.7 nM 10.1021/jm9802012
Homo sapiens MT4 EC50 2.0 nM 10.1016/0960-894X(96)00216-8
Homo sapiens MT4 EC50 2.0 nM 10.1021/jm00050a015
Homo sapiens MT4 EC50 2.0 nM 10.1021/jm00060a013
Homo sapiens MT4 EC50 2.0 nM 10.1021/jm950605j
Homo sapiens MT4 EC50 2.5 nM 10.1016/0960-894X(94)80009-X
Homo sapiens MT4 EC50 2.6 nM 10.1016/0960-894X(94)80009-X
Homo sapiens MT4 EC50 2.8 nM 10.1021/jm00015a008
Homo sapiens MT4 EC50 2.8 nM 10.1021/jm00103a009
Homo sapiens MT4 EC50 3.0 nM 10.1021/jm00050a015
Homo sapiens MT4 EC50 3.0 nM 10.1021/jm00060a013
Homo sapiens MT4 EC50 3.0 nM 10.1021/jm00108a041
Homo sapiens MT4 EC50 3.0 nM 10.1021/jm00171a023
Homo sapiens MT4 EC50 3.0 nM 10.1021/jm950605j
Homo sapiens MT4 EC50 4.0 nM 10.1016/0960-894X(96)00355-1
Homo sapiens MT4 EC50 4.0 nM 10.1021/jm00012a002
Homo sapiens MT4 EC50 4.0 nM 10.1021/jm00047a013
Homo sapiens MT4 EC50 4.5 nM 10.1021/jm00170a016
Homo sapiens MT4 EC50 5.0 nM 10.1021/jm9507338
Homo sapiens MT4 EC50 5.0 nM 10.1021/jm980531m
Homo sapiens MT4 EC50 6.0 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens MT4 EC50 6.0 nM 10.1021/jm00170a016
Homo sapiens MT4 EC50 6.4 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens MT4 EC50 9.9 nM 10.1016/j.bmcl.2003.10.036
Homo sapiens MT4 EC50 10.0 nM 10.1021/jm00017a010
Homo sapiens MT4 EC50 10.0 nM 10.1021/jm00020a015
Homo sapiens MT4 EC50 10.0 nM 10.1021/jm00047a011
Homo sapiens MT4 EC50 10.0 nM 10.1021/jm950568w
Homo sapiens MT4 EC50 10.0 nM 10.1021/jm960802y
Homo sapiens MT4 EC50 12.0 nM 10.1021/jm010863i
Homo sapiens MT4 EC50 12.0 nM 10.1021/jm010969d
Homo sapiens MT4 EC50 13.0 nM 10.1021/jm0601912
Homo sapiens MT4 EC50 15.0 nM 10.1021/jm000996o
Homo sapiens MT4 EC50 15.0 nM 10.1021/jm021016y
Homo sapiens MT4 EC50 16.0 nM 10.1021/jm00132a002
Homo sapiens MT4 EC50 17.0 nM 10.1021/jm00020a007
Homo sapiens MT4 EC50 18.0 nM 10.1021/jm049429h
Homo sapiens MT4 EC50 19.0 nM 10.1021/jm0601912
Homo sapiens MT4 EC50 20.0 nM 10.1021/jm00073a011
Homo sapiens MT4 EC50 20.0 nM 10.1021/jm030116g
Homo sapiens MT4 EC50 20.0 nM 10.1021/jm991125l
Homo sapiens MT4 EC50 25.0 nM 10.1021/jm010969d
Homo sapiens MT4 EC50 35.0 nM 10.1016/0960-894X(95)00208-B
Homo sapiens MT4 EC50 40.0 nM 10.1016/0960-894X(95)00585-H
Homo sapiens MT4 EC50 40.0 nM 10.1021/jm00020a015
Homo sapiens MT4 EC50 40.0 nM 10.1021/jm00047a011
Homo sapiens MT4 EC50 85.0 nM 10.1021/jm00045a008
Homo sapiens MT4 EC50 300.0 nM 10.1016/s0960-894x(02)00041-0
Homo sapiens MT4 EC50 300.0 nM 10.1021/jm00015a008
Homo sapiens MT4 ED50 0.004 uM 10.1021/jm00096a011
Homo sapiens MT4 ED50 0.004 uM 10.1021/jm00164a059
Homo sapiens MT4 ED50 0.006 uM 10.1021/jm00394a034
Homo sapiens MT4 EIC50 0.003 uM 10.1021/jm960802y
Homo sapiens MT4 EIC50 0.013 uM 10.1021/jm960802y
Homo sapiens MT4 IC50 0.02 ug.mL-1 10.1021/jm00023a004
Homo sapiens MT4 IC50 4.0 nM 10.1021/jm00115a007
Homo sapiens MT4 IC50 5.0 nM 10.1021/jm00001a001
Homo sapiens MT4 IC50 40.0 nM 10.1016/s0960-894x(04)00205-7
Homo sapiens MT4 IC50 57.28 ug.mL-1 10.1021/jm00023a004
Homo sapiens MT4 IC50 60.0 nM 10.1021/jm00095a014
Homo sapiens MT4 IC50 35600.0 nM 10.1021/jm000038m
Homo sapiens MT4 IC50 37400.0 nM 10.1016/j.bmc.2010.06.092
Homo sapiens MT4 IC50 37500.0 nM 10.1021/jm0601912
Homo sapiens MT4 IC50 53000.0 nM 10.1021/jm00170a016
Homo sapiens MT4 IC50 100000.0 nM 10.1021/jm980531m
Homo sapiens MT4 IC95 12.0 nM 10.1021/jm00099a007
Homo sapiens MT4 ID50 0.004 uM 10.1021/jm011011l
Homo sapiens MT4 ID50 0.017 uM 10.1021/jm0310176
Homo sapiens MT4 ID50 0.06 ug ml-1 10.1016/S0960-894X(00)80050-5
Homo sapiens MT4 ID90 0.75 uM 10.1021/jm0310176
Homo sapiens MT4 IS 11029.0 None 10.1021/jm0310176
Homo sapiens MT4 No. of infected cells 2.1 % 10.1021/jm00042a005
Homo sapiens MT4 No. of infected cells 2.9 % 10.1021/jm00042a005
Homo sapiens MT4 Protection 10.0 % 10.1021/jm00391a003
Homo sapiens MT4 Protection 40.0 % 10.1021/jm00391a003
Homo sapiens MT4 Protection 90.0 % 10.1021/jm00391a003
Homo sapiens MT4 Ratio 2000.0 None 10.1021/jm950568w
Homo sapiens MT4 Ratio 3000.0 None 10.1021/jm00050a015
Homo sapiens MT4 Selectivity index 1000.0 None 10.1021/jm980358u
Homo sapiens MT4 Selectivity index 1250.0 None 10.1021/jm00105a055
Homo sapiens MT4 Selectivity index 1603.0 None 10.1021/jm00168a046
Homo sapiens MT4 Selectivity index 2600.0 None 10.1021/jm00103a009
Homo sapiens MT4 Selectivity index 5000.0 None 10.1021/jm00118a033
Homo sapiens MT4 Selectivity index 6200.0 None 10.1021/jm00106a040
Homo sapiens MT4 SI 1300.0 None 10.1021/jm9600499
Homo sapiens MT4 SI 1300.0 None 10.1021/jm970443m
Homo sapiens MT4 SI 2000.0 None 10.1021/jm00017a010
Homo sapiens MT4 Toxicity 10.0 % 10.1021/jm00391a003
Homo sapiens MT4 Toxicity 90.0 % 10.1021/jm00391a003
Homo sapiens MT4 Viable cells 69.7 % 10.1021/jm00042a005
Homo sapiens MT4 Viable cells 78.6 % 10.1021/jm00042a005
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1097/00002030-200209060-00005
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens NALM-6 Reduction nan None 10.1016/s0960-894x(99)00581-8
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens NHDF IC50 14410.0 nM 10.1016/j.bmcl.2019.08.003
Homo sapiens NHDF IC50 14410.0 nM 10.1021/acs.jmedchem.6b00764
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 61130.6 nM None
Homo sapiens PBMC Activity nan None 10.1128/aac.00068-10
Homo sapiens PBMC Activity nan None 10.1128/aac.01443-09
Homo sapiens PBMC CC20 1153.0 uM 10.1021/jm070285r
Homo sapiens PBMC CC50 31.2 ug.mL-1 10.1016/j.bmc.2011.01.024
Homo sapiens PBMC CC50 1000.0 nM 10.1016/j.bmcl.2006.04.085
Homo sapiens PBMC CC50 1000.0 nM 10.1021/jm0508890
Homo sapiens PBMC CC50 75000.0 nM 10.1016/j.bmc.2009.11.016
Homo sapiens PBMC CC50 100000.0 nM 10.1016/j.bmc.2014.10.003
Homo sapiens PBMC CC50 100000.0 nM 10.1016/j.bmcl.2013.03.077
Homo sapiens PBMC CC50 100000.0 nM 10.1016/j.ejmech.2011.02.014
Homo sapiens PBMC CC50 100000.0 nM 10.1016/j.ejmech.2015.09.015
Homo sapiens PBMC CC50 100000.0 nM 10.1128/aac.00392-09
Homo sapiens PBMC CC50 126000.0 nM 10.1016/j.bmc.2009.06.037
Homo sapiens PBMC CC50 128000.0 nM 10.1016/j.bmcl.2012.06.020
Homo sapiens PBMC CC50 1071000.0 nM 10.1016/j.ejmech.2019.111714
Homo sapiens PBMC EC50 1.8 nM 10.1021/jm050096d
Homo sapiens PBMC EC50 4.0 nM 10.1021/jm00042a011
Homo sapiens PBMC EC50 4.0 nM 10.1021/jm0303148
Homo sapiens PBMC EC50 24.0 nM 10.1016/j.bmcl.2003.10.036
Homo sapiens PBMC EC90 0.003 uM 10.1021/jm0303148
Homo sapiens PBMC EC90 0.01 uM 10.1021/jm0303148
Homo sapiens PBMC GI25 15.0 uM 10.1021/jm070285r
Homo sapiens PBMC IC50 0.14 nM 10.1021/jm0508890
Homo sapiens PBMC IC50 0.18 nM 10.1021/jm0508890
Homo sapiens PBMC IC50 4.0 nM 10.1016/s0960-894x(99)00324-8
Homo sapiens PBMC IC50 100000.0 nM 10.1007/s00044-011-9912-x
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmc.2006.11.026
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmc.2008.10.078
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmc.2011.01.047
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmc.2012.09.026
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmcl.2009.11.031
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmcl.2011.09.089
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmcl.2013.09.009
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.bmcl.2015.01.007
Homo sapiens PBMC IC50 100000.0 nM 10.1016/j.ejmech.2011.05.051
Homo sapiens PBMC IC50 100000.0 nM 10.1021/jm00042a011
Homo sapiens PBMC IC50 100000.0 nM 10.1021/jm050096d
Homo sapiens PBMC IC50 100000.0 nM 10.1021/jm050912h
Homo sapiens PBMC IC50 100000.0 nM 10.1021/jm980651u
Homo sapiens PBMC IC50 100000.0 nM 10.1021/np9700275
Homo sapiens PBMC TC50 1000.0 nM 10.1016/j.bmcl.2012.07.037
Homo sapiens PC-3 IC50 nan nM 10.1021/jm980510s
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 37933.0 nM None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma Fu 0.695 None 10.1124/dmd.110.037457
Homo sapiens Plasma K(p,uu,CSF) 1.04 None 10.1021/jm901036q
Homo sapiens Plasma T1/2 1.0 hr 10.1128/aac.01626-06
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein kinase C beta IC50 150000.0 nM 10.1021/np50104a008
Homo sapiens Protein kinase C epsilon IC50 150000.0 nM 10.1021/np50104a008
Homo sapiens Pyruvate kinase isozymes M1/M2 Potency 39810.7 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 28963.3 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Potency 29934.9 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Serum albumin Ka nan None 10.1016/j.bmcl.2011.12.076
Homo sapiens Serum albumin Kd 44000.0 nM 10.1016/j.bmcl.2015.05.099
Homo sapiens Serum albumin Log K' 1.02 None 10.1021/jm010960b
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens SK-MEL-28 IC50 10000.0 nM 10.1021/jm980510s
Homo sapiens SK-MES-1 IC50 100000.0 nM 10.1021/jm980510s
Homo sapiens Sodium channel protein type V alpha subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Solute carrier family 22 member 1 Inhibition 4.7 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 11 Activity 84.2 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 11 Km 151800.0 nM 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 2 Activity nan None 10.1097/01.asn.0000019413.78751.46
Homo sapiens Solute carrier family 22 member 5 Activity nan None None
Homo sapiens Solute carrier family 22 member 6 Activity 30.7 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 6 Activity nan None 10.1038/nrd3028
Homo sapiens Solute carrier family 22 member 6 Km 45900.0 nM 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 7 Activity 76.7 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 7 Km 26800.0 nM 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 8 Activity 70.0 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 8 Activity nan None 10.1124/mol.59.5.1277
Homo sapiens Solute carrier family 22 member 8 Km 145100.0 nM 10.1124/jpet.300.3.918
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 9.5 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 134.05 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 7.1 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 95.75 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 4.7 % 10.1021/jm300212s
Homo sapiens SUP-T1 IC50 50.0 nM 10.1016/0960-894X(95)00306-E
Homo sapiens SW-620 IC50 39110.0 nM 10.1016/j.bmc.2014.09.046
Homo sapiens T-cell line CC50 66000.0 nM 10.1021/jm00111a045
Homo sapiens Telomerase reverse transcriptase Inhibition nan % 10.1016/j.ejmech.2016.01.014
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thymidine kinase, cytosolic Activity 47.3 % 10.1016/j.bmc.2010.03.023
Homo sapiens Thymidine kinase, cytosolic Activity 50.0 % 10.1016/j.bmc.2010.03.023
Homo sapiens Thymidine kinase, cytosolic IC50 3000.0 nM 10.1016/j.bmc.2010.03.023
Homo sapiens Thymidine kinase, cytosolic Inhibition nan % 10.1021/jm021108n
Homo sapiens Thymidine kinase, cytosolic Ki 2900.0 nM 10.1021/jm00163a043
Homo sapiens Thymidine kinase, cytosolic Ki 7000.0 nM 10.1021/jm00163a043
Homo sapiens Thymidine kinase, cytosolic Km 2900.0 nM 10.1128/aac.00692-07
Homo sapiens Thymidine kinase, cytosolic Km 3000.0 nM 10.1128/aac.00692-07
Homo sapiens Thymidine kinase, cytosolic Km 3500.0 nM 10.1016/j.bmc.2010.03.023
Homo sapiens Thymidine kinase, cytosolic Ratio 220.0 /min.mg 10.1016/j.bmc.2010.03.023
Homo sapiens Thymidine kinase, cytosolic Vmax 770.0 nmol/mg.min 10.1016/j.bmc.2010.03.023
Homo sapiens Thymidylate kinase Activity 0.27 pmol 10.1128/aac.01432-06
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 7499.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 18356.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 21136.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29855.4 nM None
Homo sapiens TZM CC50 374.0 nM 10.1016/j.bmcl.2020.127287
Homo sapiens TZM CC50 6300.0 nM 10.1016/j.ejmech.2020.113063
Homo sapiens TZM CC50 100000.0 nM 10.1016/j.bmc.2020.115812
Homo sapiens TZM CC50 872000.0 nM 10.1016/j.ejmech.2019.111714
Homo sapiens TZM CC50 nan None 10.1016/j.bmcl.2017.08.049
Homo sapiens U1 EC50 25000.0 nM 10.1021/jm000260r
Homo sapiens U1 Of control 87.0 % 10.1021/jm00108a025
Homo sapiens U1 Of control 90.0 % 10.1021/jm00108a025
Homo sapiens U1 Of control 101.0 % 10.1021/jm00108a025
Homo sapiens U-87 MG IC50 11880.0 nM 10.1016/j.bmcl.2019.08.003
Homo sapiens U-937 CC50 110000.0 nM 10.1021/jm00001a001
Homo sapiens U-937 EC50 30.0 nM 10.1021/jm00045a008
Homo sapiens U-937 IC50 40.0 nM 10.1021/jm00001a001
Homo sapiens U-937 ID50 0.03 ug ml-1 10.1021/jm00170a017
Homo sapiens U-937 TCID50 7.5 ug ml-1 10.1021/jm00170a017
Homo sapiens UDP-glucuronosyltransferase 1-1 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 1-6 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 1-9 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 2B7 Activity nan None None
Homo sapiens UDP-glucuronosyltransferase 2B7 Drug metabolism 0.14 nmol/min/mg 10.1124/dmd.111.042150
Homo sapiens UDP-glucuronosyltransferase 2B7 Ki 150000.0 nM 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Ki 200000.0 nM 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Km 307000.0 nM 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Km 330000.0 nM 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Km 519000.0 nM 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Km 770000.0 nM 10.1016/j.pharmthera.2004.10.013
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax 6.52 pmol/min 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax 20.5 pmol/min 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax 210.0 pmol/min/mg protein 10.1016/j.pharmthera.2004.10.013
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax 274.0 pmol/min 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax 1214.0 pmol/min 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax/Km 0.013 pl/min 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax/Km 0.04 pl/min 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax/Km 0.87 pl/min 10.1124/dmd.110.036608
Homo sapiens UDP-glucuronosyltransferase 2B7 Vmax/Km 3.67 pl/min 10.1124/dmd.110.036608
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Human alphaherpesvirus 1 Human alphaherpesvirus 1 CC50 nan nM 10.1016/s0960-894x(99)00010-4
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.52 ug.mL-1 10.1016/s0960-894x(02)00394-3
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 100000.0 nM 10.1021/jm970275y
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 nan nM 10.1016/s0960-894x(99)00010-4
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 nan ug.mL-1 10.1016/s0960-894x(98)00122-x
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 nan None 10.1016/j.ejmech.2006.11.002
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 nan None 10.1021/np034052o
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 100.0 ug.mL-1 10.1016/s0960-894x(02)00394-3
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 100000.0 nM 10.1021/jm970275y
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 nan ug.mL-1 10.1016/s0960-894x(98)00122-x
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 nan None 10.1016/j.ejmech.2006.11.002
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 nan None 10.1021/np034052o
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 nan ug.mL-1 10.1016/s0960-894x(98)00122-x
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 nan None 10.1016/j.ejmech.2006.11.002
Human immunodeficiency virus Human immunodeficiency virus Activity 0.7 None 10.1016/j.bmcl.2007.11.125
Human immunodeficiency virus Human immunodeficiency virus Activity 1.2 None 10.1016/j.bmcl.2007.11.125
Human immunodeficiency virus Human immunodeficiency virus Activity 50.0 None 10.1016/j.bmcl.2007.11.125
Human immunodeficiency virus Human immunodeficiency virus EC50 0.0008 ug.mL-1 10.1016/j.bmc.2008.11.056
Human immunodeficiency virus Human immunodeficiency virus EC50 0.0015 ug.mL-1 10.1016/j.bmc.2008.11.056
Human immunodeficiency virus Human immunodeficiency virus EC50 0.01 ug.mL-1 10.1021/np970497z
Human immunodeficiency virus Human immunodeficiency virus EC50 2.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 4.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 4.0 nM 10.1021/jm00054a001
Human immunodeficiency virus Human immunodeficiency virus EC50 4.0 nM 10.1021/np010216u
Human immunodeficiency virus Human immunodeficiency virus EC50 6.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 8.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 9.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 10.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 11.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 13.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 13.7 nM 10.1016/j.bmcl.2007.05.026
Human immunodeficiency virus Human immunodeficiency virus EC50 16.0 nM 10.1021/jm00105a055
Human immunodeficiency virus Human immunodeficiency virus EC50 18.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 20.0 nM 10.1021/acs.jnatprod.2c00752
Human immunodeficiency virus Human immunodeficiency virus EC50 20.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus EC50 40.0 nM 10.1016/j.bmcl.2004.09.032
Human immunodeficiency virus Human immunodeficiency virus EC50 100.0 nM 10.1021/jm00045a008
Human immunodeficiency virus Human immunodeficiency virus ED50 0.001 uM 10.1016/j.bmc.2011.07.022
Human immunodeficiency virus Human immunodeficiency virus IC50 0.0002 ug.mL-1 10.1021/np980481o
Human immunodeficiency virus Human immunodeficiency virus IC50 2.5 nM 10.1021/jm020537i
Human immunodeficiency virus Human immunodeficiency virus IC50 10.0 nM 10.1021/jm00170a019
Human immunodeficiency virus Human immunodeficiency virus Inhibition 98.1 % 10.1016/j.ejmech.2012.04.010
Human immunodeficiency virus Human immunodeficiency virus Inhibition 100.0 % 10.1016/j.ejmech.2012.04.020
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 0.7 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 1.1 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 1.8 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 2.0 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 2.4 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus TI 41667.0 None 10.1016/s0960-894x(98)00367-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 9.5 % 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 18.0 % 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 40.0 % 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 49.0 % 10.1021/np50086a006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 55.0 % 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 100.0 % 10.1021/np50086a006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 132.0 % 10.1021/jm401742r
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1016/j.bmc.2008.07.078
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1016/j.bmcl.2017.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1021/acs.jnatprod.7b00659
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1021/jm701585h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1073/pnas.0700781104
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1074/jbc.m609864200
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1128/aac.00972-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 CC50 7800.0 nM 10.1021/jm00108a023
Human immunodeficiency virus 1 Human immunodeficiency virus 1 CC50 16500.0 nM 10.1016/s0960-894x(99)00010-4
Human immunodeficiency virus 1 Human immunodeficiency virus 1 CC50 5041000.0 nM 10.1016/j.bmcl.2010.12.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Cytotoxicity 3.0 % 10.1021/jm00167a002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Cytotoxicity 30.0 % 10.1021/jm00167a002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Cytotoxicity 54.0 % 10.1021/jm00167a002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.001 ug.mL-1 10.1021/np020234r
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0012 ug.mL-1 10.1016/j.bmcl.2011.03.105
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.00132 ug.mL-1 10.1016/s0960-894x(98)00122-x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0019 ug.mL-1 10.1016/j.bmc.2015.12.008
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.002 ug.mL-1 10.1007/s00044-011-9662-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.002 ug.mL-1 10.1007/s00044-011-9664-7
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.002 ug.mL-1 10.1007/s00044-011-9705-2
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.002 ug.mL-1 10.1007/s00044-011-9776-0
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0022 ug.mL-1 10.1039/d2md00076h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.00289 ug.mL-1 10.1021/np010211x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.00324 ug.mL-1 10.1016/j.bmcl.2010.04.132
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0033 ug.mL-1 10.1016/j.bmcl.2010.12.055
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0033 ug.mL-1 10.1021/np060047j
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0034 ug.mL-1 10.1021/np0503303
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0034 ug.mL-1 10.1021/np0704396
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.004 nM 10.1021/np200058c
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.004 nM 10.1021/np200087d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.004 ug.mL-1 10.1016/j.bmcl.2010.06.056
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0043 ug.mL-1 10.1021/np0700927
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0043 ug.mL-1 10.1021/np300745q
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0045 ug.mL-1 10.1021/np900292e
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.0045 ug.mL-1 10.1021/np900849y
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.012 ug.mL-1 10.1021/np060124a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.012 ug.mL-1 10.1021/np990281s
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.016 ug.mL-1 10.1021/np000518g
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.02 ug.mL-1 10.1016/j.bmc.2009.05.049
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.034 ug.mL-1 10.1021/np300395m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.034 ug.mL-1 10.1021/np300727f
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.045 ug.mL-1 10.1021/np980291d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.53 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.7 nM 10.1016/j.bmc.2007.10.013
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.73 nM 10.1016/j.bmc.2006.11.026
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.8 nM 10.1016/j.ejmech.2006.11.002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.96 nM 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.0 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.0 nM 10.1021/acs.jmedchem.0c00117
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.0 nM 10.1021/np0003995
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.2 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.2 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.3 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.3 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.5 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.52 nM 10.1016/j.bmc.2016.03.043
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.6 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.6 nM 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.7 nM 10.1016/j.bmc.2012.09.026
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.7 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.7 nM 10.1016/s0960-894x(99)00010-4
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.7 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.8 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.9 nM 10.1016/j.bmcl.2015.01.058
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.9 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.9 nM 10.1021/jm050257d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.9 nM 10.1021/jm801395v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.9 nM 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.95 nM 10.1021/np900123z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1016/j.bmc.2016.05.010
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1016/j.bmcl.2012.07.037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1016/j.ejmech.2018.03.007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1021/jm00397a011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1021/jm2001103
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1021/jm980510s
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.1 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.2 nM 10.1016/j.ejmech.2018.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.5 nM 10.1016/j.bmc.2011.01.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.7 nM 10.1021/jm040027j
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.7 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.9 nM 10.1007/s00044-011-9912-x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.9 nM 10.1016/j.bmc.2006.10.043
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.9 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1016/j.bmc.2008.06.024
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1016/j.bmc.2012.08.008
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1021/jm00103a009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1021/jm00108a023
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1021/jm050744t
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1021/jm9600095
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.3 nM 10.1016/j.bmcl.2011.09.089
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.3 nM 10.1016/j.bmcl.2015.01.007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.4 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.5 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.6 nM 10.1021/acs.jmedchem.8b01729
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.7 nM 10.1016/j.bmc.2014.10.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.7 nM 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.7 nM 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.7 nM 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.8 nM 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.8 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.95 nM 10.1021/np3006887
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1016/j.bmcl.2013.03.077
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1016/j.ejmech.2012.04.038
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1016/j.ejmech.2022.114471
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/acs.jmedchem.7b00416
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/acs.jnatprod.5b01012
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm00057a001
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm00070a006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm00093a005
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm00108a028
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm010256v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm010418n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm0256225
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm030475b
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm050912h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm980651u
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.1 nM 10.1021/jm040027j
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.1 nM 10.1021/jm990050i
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.36 nM 10.1016/j.bmc.2016.03.043
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.4 nM 10.1016/j.ejmech.2011.02.014
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.5 nM 10.1021/acs.jmedchem.0c00358
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.5 nM 10.1021/jm9607921
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.5 nM 10.1021/np200146x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.6 nM 10.1021/acs.jnatprod.2c00980
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.7 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.7 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.7 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.8 nM 10.1016/j.ejmech.2015.11.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.9 nM 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.9 nM 10.1016/j.ejmech.2019.111619
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.9 nM 10.1021/acs.jmedchem.0c00117
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.9 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.9 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.bmc.2008.01.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.bmc.2018.03.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.bmcl.2009.11.031
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.bmcl.2013.09.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.ejmech.2011.05.051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.ejmech.2017.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/j.ejmech.2022.114471
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1021/acs.jmedchem.0c00358
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1021/acs.jmedchem.7b00416
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.1 nM 10.1021/acs.jmedchem.0c00117
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.1 nM 10.1021/acs.jmedchem.8b01729
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.1 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.2 nM 10.1016/j.bmc.2015.03.037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.2 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.2 nM 10.1016/j.ejmech.2015.11.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.2 nM 10.1016/j.ejmech.2017.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.3 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.3 nM 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.4 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.5 nM 10.1021/jm0504306
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.5 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.6 nM 10.1016/j.bmc.2015.03.037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.6 nM 10.1021/acs.jmedchem.8b01729
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.7 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.81 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.9 nM 10.1016/j.bmc.2013.08.040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmc.2008.01.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmc.2011.07.023
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmc.2012.04.030
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmc.2014.03.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmc.2016.05.010
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmc.2018.03.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmcl.2012.09.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.ejmech.2012.10.036
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.ejmech.2017.07.012
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.ejmech.2020.112811
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.ejmech.2022.114471
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1021/jm0308444
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1021/np200855d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.2 nM 10.1016/j.bmcl.2004.09.033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.2 nM 10.1016/j.ejmech.2018.03.007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.2 nM 10.1021/acs.jmedchem.8b01729
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.2 nM 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.3 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.3 nM 10.1039/C3MD00247K
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.3 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.3 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.4 nM 10.1039/C3MD00247K
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.6 nM 10.1016/j.bmc.2013.08.040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.7 nM 10.1016/j.ejmech.2015.11.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.bmc.2008.10.078
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.bmc.2011.07.023
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.bmc.2014.02.030
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.bmc.2014.03.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.ejmech.2012.04.004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.ejmech.2015.02.022
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.ejmech.2016.02.068
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1016/j.ejmech.2022.114471
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1021/jm981096z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.1 nM 10.1016/j.bmc.2014.11.032
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.1 nM 10.1016/j.ejmech.2014.09.054
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.1 nM 10.1016/j.ejmech.2015.01.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.1 nM 10.1016/j.ejmech.2015.11.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.1 nM 10.1016/j.ejmech.2017.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.1 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.1 nM 10.1021/acs.jnatprod.5b00116
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.2 nM 10.1016/j.bmc.2013.10.033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.4 nM 10.1016/j.bmc.2013.10.033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.4 nM 10.1016/j.ejmech.2015.09.015
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.4 nM 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.5 nM 10.1016/j.bmc.2011.10.002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.5 nM 10.1016/j.ejmech.2014.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.5 nM 10.1016/j.ejmech.2019.111619
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.5 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.5 nM 10.1021/jm001033s
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.6 nM 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.7 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.8 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.8 nM 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.9 nM 10.1016/j.ejmech.2019.111619
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.9 nM 10.1016/s0960-894x(01)00323-7
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.94 nM 10.1016/j.bmc.2016.03.043
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.bmc.2010.09.070
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.bmc.2014.02.030
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.bmc.2016.04.010
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.bmc.2016.05.010
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.bmc.2018.03.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.bmcl.2012.07.037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.ejmech.2012.10.036
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1021/jm050744t
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1021/jm500139a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.12 nM 10.1016/j.bmc.2011.05.060
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.3 nM 10.1016/j.ejmech.2015.11.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.3 nM 10.1016/j.ejmech.2017.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.3 nM 10.1021/acsmedchemlett.7b00524
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.4 nM 10.1016/j.ejmech.2022.114512
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.4 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.6 nM 10.1016/j.ejmech.2012.02.019
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.6 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.7 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.7 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.7 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.7 nM 10.1021/jm301226a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1016/j.bmc.2009.02.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1016/j.bmcl.2012.09.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1016/j.ejmech.2020.112811
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1021/jm500139a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1021/np9700275
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1128/aac.01448-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.3 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.6 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.7 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.9 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.9 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1007/s00044-010-9513-0
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1007/s00044-012-0342-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.bmc.2009.02.033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.bmc.2012.04.030
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.bmc.2012.07.026
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.bmc.2014.11.032
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.ejmech.2013.04.052
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.ejmech.2014.09.054
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.ejmech.2015.01.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.ejmech.2015.02.022
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.ejmech.2019.111619
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.ejmech.2021.113868
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/j.ejmech.2022.114471
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/S0960-894X(97)00340-5
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1021/acs.jmedchem.5b01183
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1021/jm00076a005
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1021/jm500139a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.59 nM 10.1016/j.bmc.2011.05.060
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.8 nM 10.1016/j.bmcl.2007.06.008
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.8 nM 10.1016/j.ejmech.2022.114512
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.8 nM 10.1021/np070479+
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1016/j.bmcl.2008.02.040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1016/j.ejmech.2015.11.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1016/j.ejmech.2017.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1016/j.ejmech.2017.07.012
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1021/acs.jmedchem.8b01729
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1021/jm00010a008
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1021/jm001033s
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.0 nM 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.36 nM 10.1016/j.bmc.2018.03.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.7 nM 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.0 nM 10.1016/j.bmc.2018.03.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.0 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.0 nM 10.1016/j.ejmech.2013.09.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.0 nM 10.1016/j.ejmech.2019.111619
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.6 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.6 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.7 nM 10.1021/acs.jmedchem.0c00117
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.8 nM 10.1016/j.bmc.2011.07.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.8 nM 10.1016/j.ejmech.2012.03.032
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.82 nM 10.1016/j.bmc.2011.06.007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.bmc.2011.10.002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.bmc.2015.06.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.ejmech.2012.04.004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.ejmech.2015.11.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.ejmech.2017.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.0 nM 10.1021/acs.jmedchem.8b01729
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.1 nM 10.1021/acsmedchemlett.7b00524
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.5 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.5 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.7 nM 10.1021/np0603166
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1016/j.bmc.2008.06.024
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1016/j.bmc.2011.05.024
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1016/j.bmc.2015.06.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1016/j.ejmech.2019.01.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1021/acs.jmedchem.8b01729
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.1 nM 10.1007/s00044-009-9220-x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.1 nM 10.1016/j.bmc.2009.07.028
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.1 nM 10.1016/j.bmcl.2008.09.055
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.1 nM 10.1016/j.ejmech.2009.06.037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.6 nM 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1016/0960-894X(96)00334-4
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1016/j.bmc.2016.05.010
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1016/j.bmcl.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1016/j.ejmech.2014.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1016/j.ejmech.2020.112811
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 nM 10.1016/j.ejmech.2016.02.068
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 nM 10.1016/j.ejmech.2021.113315
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 nM 10.1021/jm0308444
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 nM 10.1021/np0605236
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 18.0 nM 10.1016/j.bmc.2018.03.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 18.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 18.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 18.3 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 18.3 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 19.0 nM 10.1016/j.bmcl.2012.09.070
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 19.0 nM 10.1016/j.ejmech.2020.112811
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 19.0 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 19.1 nM 10.1016/j.ejmech.2018.07.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1016/j.bmc.2011.12.055
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/acs.jnatprod.5b00392
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/acs.jnatprod.8b00243
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/jm040093l
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/jm0607404
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/jm500139a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/jm9903390
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/np034052o
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1021/np400546z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.1 nM 10.1016/j.bmc.2021.116195
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.1 nM 10.1016/j.ejmech.2020.113063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.6 nM 10.1016/j.ejmech.2012.02.019
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.0 nM 10.1016/j.bmc.2012.09.058
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.0 nM 10.1016/j.ejmech.2022.114471
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.0 nM 10.1039/C3MD00028A
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.2 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 22.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 22.0 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 22.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 22.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 22.8 nM 10.1016/j.ejmech.2012.03.032
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 22.9 nM 10.1016/j.ejmech.2022.114512
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.0 nM 10.1016/j.bmc.2011.06.007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.0 nM 10.1016/j.bmc.2011.07.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.0 nM 10.1021/np060239e
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.86 nM 10.1021/acs.jnatprod.1c00896
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.0 nM 10.1016/j.ejmech.2020.112811
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.0 nM 10.1016/j.ejmech.2021.113315
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.2 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.2 nM 10.1016/j.ejmech.2022.114512
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 25.0 nM 10.1021/jm001033s
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 25.0 nM 10.1021/jm060030y
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 26.0 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 26.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 26.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 26.8 nM 10.1016/j.ejmech.2022.114512
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 27.0 nM 10.1016/j.bmc.2010.06.092
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 27.0 nM 10.1016/j.ejmech.2020.112811
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 27.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 27.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 28.0 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 28.7 nM 10.1016/j.ejmech.2022.114512
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 29.0 nM 10.1016/j.ejmech.2021.113868
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1021/acs.jmedchem.5b01183
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1021/jm00073a011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 31.0 nM 10.1016/j.ejmech.2021.113868
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 32.0 nM 10.1016/j.ejmech.2021.113868
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 32.0 nM 10.1021/acs.jnatprod.5b00660
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 33.0 nM 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 33.0 nM 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 33.0 nM 10.1016/j.ejmech.2021.113868
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 33.0 nM 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 33.0 nM 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 34.0 nM 10.1021/jm901782m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 34.0 nM 10.1021/np400070x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 34.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 34.7 nM 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 35.0 nM 10.1016/j.bmc.2021.116239
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 36.0 nM 10.1016/j.ejmech.2020.113051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 38.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 38.6 nM 10.1021/acsmedchemlett.7b00524
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 40.0 nM 10.1016/j.bmc.2013.06.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 40.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 40.0 nM 10.1021/np50103a006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 40.0 nM 10.1021/np50104a008
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 43.0 nM 10.1016/j.bmc.2020.115488
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 43.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 44.0 nM 10.1016/j.bmc.2010.04.089
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 44.0 nM 10.1021/acs.jmedchem.5b00737
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 44.0 nM 10.1021/np900821e
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 45.0 nM 10.1021/np0101189
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 47.0 nM 10.1016/j.ejmech.2011.06.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 48.0 nM 10.1016/s0960-894x(00)00535-7
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 50.0 nM 10.1016/j.bmc.2006.12.013
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 50.0 nM 10.1016/j.bmc.2009.06.037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 50.0 nM 10.1021/jm980358u
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 51.0 nM 10.1016/j.ejmech.2021.113868
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 51.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 52.0 nM 10.1021/jm1002952
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 53.0 nM 10.1021/jm050257d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 53.0 nM 10.1128/aac.00686-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 54.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 56.0 nM 10.1021/jm900136j
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 58.0 nM 10.1016/j.bmcl.2012.04.032
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 71.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 75.0 nM 10.1021/jm020069c
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 75.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 84.0 nM 10.1016/j.bmcl.2011.09.040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 84.0 nM 10.1016/j.ejmech.2013.02.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 87.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 87.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 90.0 nM 10.1016/j.bmc.2012.08.008
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 94.0 nM 10.1016/j.bmc.2020.115923
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100.0 nM 10.1016/j.bmc.2009.02.033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100.0 nM 10.1016/j.ejmech.2019.111653
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 110.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 117.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 120.0 nM 10.1016/j.bmc.2015.06.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 120.0 nM 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 120.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 126.0 nM 10.1016/j.ejmech.2018.03.007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 140.0 nM 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 144.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 150.0 nM 10.1016/j.ejmech.2019.111864
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 150.0 nM 10.1021/jm00049a014
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 160.0 nM 10.1016/j.bmc.2007.05.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 160.0 nM 10.1016/j.bmc.2008.12.028
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 160.0 nM 10.1016/j.bmcl.2007.11.125
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 160.0 nM 10.1016/j.bmcl.2012.06.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 160.0 nM 10.1016/j.ejmech.2019.111864
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 160.0 nM 10.1128/aac.01004-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 170.0 nM 10.1016/j.bmc.2011.12.055
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 180.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 180.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 187.0 nM 10.1021/jm030416y
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 190.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 200.0 nM 10.1021/jm500139a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 200.0 nM 10.1021/np200855d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 200.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 209.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 210.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 223.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 249.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 280.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 300.0 nM 10.1016/j.bmc.2020.115488
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 302.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 330.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 340.0 nM 10.1016/j.bmcl.2007.09.081
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 340.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 340.0 nM 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 350.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 380.0 nM 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 390.0 nM 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 400.0 nM 10.1021/jm0010365
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 450.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 459.0 nM 10.1016/j.bmc.2011.12.055
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 510.0 nM 10.1016/j.bmc.2015.06.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 560.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 600.0 nM 10.1016/j.bmc.2009.02.033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 600.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 620.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 640.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 660.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 770.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 890.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1000.0 nM 10.1016/s0960-894x(98)00380-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1000.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1000.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1050.0 nM 10.1016/j.ejmech.2011.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1100.0 nM 10.1016/j.bmc.2010.12.031
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1100.0 nM 10.1016/j.ejmech.2019.07.019
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1300.0 nM 10.1021/np400847t
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1600.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2200.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2470.0 nM 10.1128/aac.00274-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2500.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2700.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3000.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3300.0 nM 10.1016/j.bmc.2020.115923
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4200.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4500.0 nM 10.1021/jm9900624
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4600.0 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5600.0 nM 10.1016/j.ejmech.2019.111864
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5700.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6000.0 nM 10.1016/j.bmc.2012.07.026
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7000.0 nM 10.1128/aac.01004-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7100.0 nM 10.1021/acs.jnatprod.5b00073
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7480.0 nM 10.1021/acs.jmedchem.5b01183
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7900.0 nM 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8700.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9600.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10000.0 nM 10.1016/j.ejmech.2019.111864
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10000.0 nM 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10800.0 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14200.0 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15000.0 nM 10.1016/j.ejmech.2019.111864
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16000.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20000.0 nM 10.1016/j.bmc.2012.12.044
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20000.0 nM 10.1016/j.ejmech.2017.04.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 25000.0 nM 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 28070.0 nM 10.1016/j.ejmech.2019.111619
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 75000.0 nM 10.1021/jm020069c
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 87000.0 nM 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100000.0 nM 10.1016/j.bmc.2008.06.024
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100000.0 nM 10.1016/j.ejmech.2011.05.051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100000.0 nM 10.1016/j.ejmech.2021.113315
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100000.0 nM 10.1021/acs.jmedchem.0c00358
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 100000.0 nM 10.1021/jm0308444
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 nan None 10.1016/j.bmc.2015.06.020
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 nan None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 nan None 10.1128/aac.01727-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.0027 uM 10.1016/j.bmc.2012.09.026
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.005 uM 10.1021/jm2001103
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.01 uM 10.1016/j.bmc.2011.01.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.01 uM 10.1021/jm050912h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.019 uM 10.1016/j.bmc.2006.11.026
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.02 uM 10.1016/j.bmc.2006.10.043
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.02 uM 10.1016/j.bmcl.2009.11.031
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.02 uM 10.1016/j.ejmech.2011.05.051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.02 uM 10.1021/jm980510s
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.026 uM 10.1007/s00044-011-9912-x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.028 uM 10.1016/j.bmcl.2011.09.089
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.028 uM 10.1016/j.bmcl.2013.03.077
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.031 uM 10.1016/j.bmcl.2015.01.007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.031 uM 10.1016/j.ejmech.2011.02.014
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.04 uM 10.1016/j.bmc.2008.10.078
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 0.047 uM 10.1016/j.bmc.2014.10.003
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC90 100.0 uM 10.1016/j.ejmech.2011.05.051
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC95 0.09 uM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.001 uM 10.1021/jm00033a018
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.001 uM 10.1021/jm00062a027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.003 uM 10.1021/jm00168a046
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.004 uM 10.1021/jm00118a033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.04 uM 10.1021/jm9600499
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.07 uM 10.1021/jm00062a027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.23 uM 10.1021/jm00385a033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Emax 90.0 % 10.1016/j.bmcl.2012.09.108
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.1 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.1 None 10.1128/aac.01455-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.13 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.15 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.2 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.2 None 10.1128/aac.01455-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.21 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.22 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.3 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.34 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.4 None 10.1128/aac.01455-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.41 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.44 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.5 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.5 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.51 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.6 None 10.1128/aac.01455-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.63 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.7 None 10.1016/j.bmc.2008.12.028
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.7 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.7 None 10.1128/aac.01593-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.8 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.8 None 10.1128/aac.01593-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.9 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.9 None 10.1128/aac.01593-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.1 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.1 None 10.1128/aac.01593-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.2 None 10.1016/j.bmc.2008.12.028
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.2 None 10.1128/aac.00687-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.7 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.0 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.1 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.2 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.3 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.4 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.6 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.6 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.7 None 10.1128/aac.00687-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.7 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 3.2 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 3.9 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 4.2 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 5.4 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 5.8 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 6.5 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 7.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 7.6 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 7.9 None 10.1128/aac.00870-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 12.0 None 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 20.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 22.0 None 10.1128/aac.00277-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 28.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 38.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 58.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 59.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 93.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 98.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 100.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 150.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 320.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 350.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 400.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 920.0 None 10.1128/aac.00068-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 0.7 None 10.1016/j.bmc.2007.05.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 1.2 None 10.1016/j.bmc.2007.05.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 3.0 None 10.1021/jm0708230
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 50.0 None 10.1016/j.bmc.2007.05.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FT50 7.7 hr 10.1021/acs.jnatprod.7b00659
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FT50 8.5 hr 10.1016/j.ejmech.2020.112071
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.002 ug.mL-1 10.1016/j.ejmech.2016.04.019
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.0022 ug.mL-1 10.1007/s00044-013-0567-7
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.004 ug.mL-1 10.1021/np0601399
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.005 ug.mL-1 10.1021/jm960314q
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.1 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.26 ug.mL-1 10.1016/j.bmc.2011.01.024
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.3 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.4 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.5 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.7 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.8 nM 10.1016/j.bmc.2012.06.038
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.8 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1.5 nM 10.1021/jm00106a040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1.5 nM 10.1021/jm200990c
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1.75 nM 10.1016/j.bmcl.2006.04.085
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1.95 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1.98 nM 10.1016/j.bmcl.2006.04.085
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 2.0 nM 10.1021/jm970559i
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 2.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 2.4 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 2.4 nM 10.1021/jm901758f
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 2.8 nM 10.1016/j.bmcl.2011.12.076
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 2.8 nM 10.1016/j.bmcl.2017.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 3.0 nM 10.1021/jm00023a007
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 3.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 4.0 nM 10.1021/jm00108a021
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 4.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 4.1 nM 10.1021/jm00005a006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 5.0 nM 10.1016/j.bmc.2008.11.075
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 5.0 nM 10.1016/j.bmc.2010.06.067
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 5.1 nM 10.1016/j.bmc.2009.11.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 5.2 nM 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 6.0 nM 10.1021/jm00062a006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 6.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 6.6 nM 10.1016/j.ejmech.2014.05.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.0 nM 10.1016/j.bmc.2010.05.057
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.0 nM 10.1016/j.bmc.2011.05.022
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.0 nM 10.1016/j.bmcl.2010.12.109
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.0 nM 10.1016/j.bmcl.2012.09.108
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.0 nM 10.1016/j.bmcl.2013.12.093
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.1 nM 10.1021/np500271u
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.7 nM 10.1016/j.bmc.2009.11.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7.7 nM 10.1016/j.ejmech.2014.05.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 8.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 9.0 nM 10.1016/j.bmc.2017.03.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 9.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10.0 nM 10.1016/j.bmc.2009.11.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10.0 nM 10.1016/j.bmc.2017.03.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 12.74 nM 10.1016/j.ejmech.2019.111699
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 14.0 nM 10.1021/acs.jnatprod.8b00211
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 14.0 nM 10.1128/aac.01324-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 15.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 16.0 nM 10.1016/j.ejmech.2019.111714
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 16.9 nM 10.1016/j.bmcl.2021.128319
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 18.0 nM 10.1021/jm901758f
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 18.7 nM 10.1021/acs.jnatprod.9b00088
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 20.0 nM 10.1016/j.bmc.2017.03.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 20.0 nM 10.1016/j.ejmech.2019.111714
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 20.0 nM 10.1021/acs.jnatprod.9b00993
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 21.7 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 27.0 nM 10.1016/j.ejmech.2019.111714
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 27.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 28.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1016/j.ejmech.2012.02.015
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1016/j.ejmech.2019.111714
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1021/jm301040s
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 31.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 37.0 nM 10.1016/j.bmc.2011.07.022
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 37.0 nM 10.1021/jm020537i
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 40.0 nM 10.1016/j.bmc.2012.06.038
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 40.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 43.0 nM 10.1021/jm020537i
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 47.0 nM 10.1016/j.bmcl.2010.05.090
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 48.0 nM 10.1016/j.bmc.2009.02.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 48.0 nM 10.1021/np900213w
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 49.3 nM 10.1016/j.bmcl.2010.07.106
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 50.0 nM 10.1016/j.ejmech.2019.111714
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 50.0 nM 10.1021/np2001489
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 50.0 nM 10.1021/np900305j
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 50.0 nM 10.1128/aac.01324-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 55.7 nM 10.1016/j.ejmech.2018.07.067
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 60.0 nM 10.1016/j.bmcl.2009.11.018
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 60.0 nM 10.1128/aac.01324-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 64.0 nM 10.1021/jm020537i
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 72.0 nM 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 77.0 nM 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 78.0 nM 10.1016/j.bmc.2011.07.022
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 79.0 nM 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 80.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 85.0 nM 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 95.0 nM 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 100.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 120.0 nM 10.1016/j.bmcl.2011.02.074
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 120.0 nM 10.1021/jm00167a034
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 180.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 190.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 210.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 216.2 nM 10.1039/C4MD00003J
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 250.0 nM 10.1016/j.bmc.2011.05.022
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 250.0 nM 10.1016/j.bmcl.2010.12.109
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 500.0 ug.mL-1 10.1021/np9601667
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 500.0 ug.mL-1 10.1021/np9800710
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1040.0 nM 10.1016/j.bmc.2010.03.015
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1040.0 nM 10.1016/j.bmcl.2010.06.052
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1050.0 nM 10.1016/j.bmc.2010.01.023
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1840.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 2425.0 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 3200.0 nM 10.1021/jm990050i
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 3508.0 nM 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 4000.0 nM 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 5600.0 nM 10.1021/jm00108a021
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 7700.0 nM 10.1016/j.bmc.2012.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10000.0 nM 10.1021/jm970559i
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10400.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 11900.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 35600.0 nM 10.1016/j.ejmech.2010.05.060
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 58600.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 96700.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 100000.0 nM 10.1021/jm00054a001
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 100000.0 nM 10.1021/jm00070a006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 100000.0 nM 10.1021/jm00093a005
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 204600.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 213700.0 nM 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 500000.0 nM 10.1016/j.bmc.2010.08.031
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 829100.0 nM 10.1039/C4MD00003J
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1871000.0 nM 10.1021/np990633v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1875000.0 nM 10.1021/jm9900624
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 5100000.0 nM 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 21.3 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 34.2 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 48.0 nM 10.1016/j.bmc.2011.05.022
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 100.0 nM 10.1016/j.bmc.2017.03.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 152.3 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 210.0 nM 10.1016/j.bmc.2017.03.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 350.0 nM 10.1016/j.bmc.2017.03.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 1000.0 nM 10.1016/j.bmc.2017.03.061
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 10657.0 nM 10.1021/jm201551m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ID50 0.05 ug ml-1 10.1021/jm00166a019
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 18.0 % 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 40.0 % 10.1021/acs.jnatprod.7b00004
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 50.0 % 10.1021/acs.jmedchem.7b00179
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 50.0 % 10.1128/aac.00692-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 53.0 % 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 70.0 % 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 79.0 % 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 87.0 % 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 89.75 % 10.1016/j.bmc.2010.01.023
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 89.75 % 10.1016/j.bmc.2010.03.015
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 89.75 % 10.1016/j.ejmech.2011.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 89.8 % 10.1016/j.bmc.2010.12.031
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 93.0 % 10.1021/jm00108a025
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 94.0 % 10.1016/j.bmc.2009.06.037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 100.0 % 10.1007/s00044-012-0241-5
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 100.0 % 10.1016/j.bmc.2011.01.024
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 100.0 % 10.1016/j.ejmech.2012.02.015
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1016/j.bmc.2014.08.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1016/j.bmc.2016.04.009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1016/j.bmcl.2011.12.076
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1021/jm500763m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1128/aac.00670-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1128/aac.00692-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 MIC 0.001 ug.mL-1 10.1021/jm00167a011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Protection 47.0 % 10.1021/jm00167a002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Protection 65.0 % 10.1021/jm00167a002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Protection 96.0 % 10.1021/jm00167a002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio 1400.0 None 10.1021/jm00108a021
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.1 None 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.1 None 10.1021/acs.jmedchem.0c00117
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.2 None 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.32 None 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.4 None 10.1021/acs.jmedchem.0c00117
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.44 None 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.46 None 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.5 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.5 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.57 None 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.7 None 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.7 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.7 None 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.71 None 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.72 None 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.9 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1016/j.bmc.2013.10.033
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1021/np200855d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.1 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.14 None 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.2 None 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.2 None 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.2 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.3 None 10.1021/acs.jmedchem.7b00416
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.4 None 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.4 None 10.1016/j.ejmech.2015.01.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.4 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.5 None 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.6 None 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.6 None 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.6 None 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.6 None 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.64 None 10.1016/j.bmc.2021.116531
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.9 None 10.1016/j.bmc.2012.04.030
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.9 None 10.1016/j.ejmech.2018.03.059
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.9 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.0 None 10.1021/jm300477h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.0 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.3 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.7 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.0 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.3 None 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.3 None 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.3 None 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.8 None 10.1128/aac.01313-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.3 None 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 8.9 None 10.1016/j.ejmech.2014.04.027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 8.9 None 10.1016/j.ejmech.2020.112696
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 8.9 None 10.1021/acs.jmedchem.6b01906
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 11.0 None 10.1021/np200855d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 24.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 36.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 43.0 None 10.1128/aac.01004-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 56.0 None 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 56.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 59.7 None 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 90.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 120.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 178.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 200.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 0.3 None 10.1128/aac.00687-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 0.8 None 10.1128/aac.00687-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 1.0 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 1.0 None 10.1128/aac.00687-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 1.1 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 1.124 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 54.4 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 62.7 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 307.4 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 507.4 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 1076.0 None 10.1128/aac.00392-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 4000.0 None 10.1039/C4MD00003J
Human immunodeficiency virus 1 Human immunodeficiency virus 1 SI 33333.0 None 10.1021/jm0009437
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Survival 74.3 % 10.1021/jm00093a005
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Survival 78.3 % 10.1021/jm00093a005
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Survival 79.4 % 10.1021/jm00093a005
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TC50 500.0 uM 10.1021/jm9903390
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TI 12500.0 None 10.1021/jm00049a014
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 4.0 hr 10.1016/j.ejmech.2016.03.083
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 4.0 hr 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 4.8 hr 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 5.0 hr 10.1021/jm100093p
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 7.7 hr 10.1016/j.ejmech.2014.07.072
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 11.59 hr 10.1021/np400683h
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease CD50 10.0 uM 10.1016/S0960-894X(01)80332-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease EC50 126.0 nM 10.1016/s0960-894x(99)00089-x
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease ED50 0.06 uM 10.1016/S0960-894X(01)80332-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 6.0 nM 10.1021/jm00012a002
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 16.0 nM 10.1021/jm00061a022
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 23.0 nM 10.1021/jm00061a022
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 50000.0 nM 10.1021/jm00012a002
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 nan nM 10.1016/S0960-894X(01)80332-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki nan nM 10.1021/jm00028a013
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Relative potency 1.0 None 10.1016/s0960-894x(00)00202-x
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 0.024 /min 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 100.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 302.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 337.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 400.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 500.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 542.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 576.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 600.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 620.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 757.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 900.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 913.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 965.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 972.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 984.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 1100.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 1300.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 1500.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 1700.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 2018.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 5000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 6400.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 7500.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 11000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 12000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 23000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 28000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 33000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 35000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 36000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 37000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 44421.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 54000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 60000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 108000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 118000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 134000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 152000.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity 190001.0 c.p.m. 50ul-1 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity nan None 10.1016/j.bmc.2010.12.031
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity nan None 10.1021/jm00042a005
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity nan None 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity nan None 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase CC50 100000.0 nM 10.1021/jm991125l
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase CD50 70.0 uM 10.1021/jm00025a010
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Cell viability 34.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Cell viability 79.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Cell viability 100.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 2.0 nM 10.1021/jm991125l
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 3.0 nM 10.1016/j.bmcl.2006.03.080
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 3.0 nM 10.1016/s0960-894x(01)00635-7
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 3.0 nM 10.1021/jm00051a006
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 3.0 nM 10.1021/jm00076a005
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 3.0 nM 10.1021/jm9600095
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 3.75 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 4.79 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 5.24 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 6.34 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 6.6 nM 10.1016/j.bmc.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 6.68 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 7.0 nM 10.1021/acsmedchemlett.8b00054
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 7.3 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 8.0 nM 10.1016/j.bmcl.2006.03.080
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 8.9 nM 10.1016/j.bmc.2017.03.009
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 10.0 nM 10.1021/jm00059a006
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 11.1 nM 10.1021/acs.jmedchem.7b00332
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 17.0 nM 10.1021/acsmedchemlett.8b00054
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 38.0 nM 10.1021/jm000209n
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase EC50 24900.0 nM 10.1021/jm000209n
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase ED50 0.003 uM 10.1021/jm00128a013
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase ED50 0.007 uM 10.1021/jm00025a010
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase ED50 0.07 uM 10.1021/acs.jmedchem.8b00843
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 0.0034 ug.mL-1 10.1016/j.ejmech.2019.111566
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 3.0 nM 10.1021/jm9705723
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 3.1 nM 10.1021/jm970559i
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 6.0 nM 10.1021/jm00111a045
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 10.0 nM 10.1016/0960-894X(95)00302-A
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 11.0 nM 10.1021/jm00020a026
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 17.0 nM 10.1021/jm9705723
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 30.0 nM 10.1021/jm00001a001
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 40.0 nM 10.1021/jm00096a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 50.0 nM 10.1016/j.bmc.2007.05.047
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 50.0 nM 10.1016/j.bmc.2008.12.028
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 50.0 nM 10.1016/j.bmcl.2007.11.125
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 50.0 nM 10.1021/np50121a006
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100.0 nM 10.1021/jm00115a022
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 800.0 ug.mL-1 10.1016/S0960-894X(01)80437-6
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 1400.0 nM 10.1021/jm801176e
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 3600.0 nM 10.1021/jm801176e
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 4540.0 nM 10.1016/j.bmc.2013.01.025
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 18220.0 nM 10.1016/j.bmcl.2014.05.079
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 20140.0 nM 10.1016/j.bmcl.2016.02.049
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 20520.0 nM 10.1016/j.bmcl.2012.09.100
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 21430.0 nM 10.1016/j.bmcl.2010.10.054
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100000.0 nM 10.1016/0960-894X(96)00443-X
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100000.0 nM 10.1016/0960-894X(96)00444-1
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100000.0 nM 10.1016/s0960-894x(98)00250-9
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100000.0 nM 10.1016/s0960-894x(99)00581-8
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100000.0 nM 10.1016/s0960-894x(99)00624-1
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan nM 10.1016/s0960-894x(99)00235-8
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan nM 10.1021/jm00062a027
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan None 10.1016/j.bmc.2015.03.037
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan None 10.1016/j.bmc.2016.04.010
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan None 10.1016/j.bmc.2016.05.010
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 0.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 7.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 18.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 25.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 76.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 85.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 86.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 91.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 92.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 94.25 % 10.1016/j.ejmech.2008.02.047
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 95.0 % 10.1016/j.bmc.2013.01.025
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 96.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition nan % 10.1021/acs.jmedchem.9b01737
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition nan % 10.1021/jm00062a027
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Kd 5.4 nM 10.1021/jm401232v
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Protection 26.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Protection 76.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Protection 100.0 % 10.1021/jm00110a011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Ratio 0.58 None 10.1016/j.bmcl.2015.05.099
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Ratio 0.941 None 10.1016/j.bmcl.2015.05.099
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Selectivity index 930.0 None 10.1021/jm00033a018
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Selectivity index 2000.0 None 10.1021/jm00059a006
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase SI 1600.0 None 10.1021/jm00128a013
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase SI 2632.0 None 10.1021/jm000209n
Human immunodeficiency virus 2 Human immunodeficiency virus 2 Activity nan None 10.1128/aac.01004-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 0.0009 ug.mL-1 10.1007/s00044-011-9664-7
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 0.0009 ug.mL-1 10.1007/s00044-011-9776-0
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 0.00094 ug.mL-1 10.1039/d2md00076h
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 0.0018 ug.mL-1 10.1016/j.bmc.2015.12.008
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 0.002 ug.mL-1 10.1007/s00044-011-9662-9
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 0.002 ug.mL-1 10.1007/s00044-011-9705-2
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 0.007 ug.mL-1 10.1021/np020234r
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 1.6 nM 10.1016/j.bmcl.2015.01.058
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 2.0 nM 10.1021/jm00045a008
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 2.8 nM 10.1021/jm00108a023
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 3.3 nM 10.1016/j.ejmech.2011.08.011
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 4.0 nM 10.1016/j.bmc.2012.09.058
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 4.0 nM 10.1016/j.bmcl.2012.09.062
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 4.0 nM 10.1016/s0960-894x(01)00635-7
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 4.0 nM 10.1021/jm0256225
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 4.5 nM 10.1039/C3MD00028A
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 5.0 nM 10.1016/j.bmc.2014.03.020
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 5.5 nM 10.1021/jm0504306
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 5.7 nM 10.1016/j.bmc.2013.10.033
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.0 nM 10.1016/j.bmc.2011.07.023
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.0 nM 10.1016/j.bmc.2014.02.030
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.0 nM 10.1016/j.ejmech.2012.10.036
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.0 nM 10.1021/acs.jnatprod.5b00116
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.0 nM 10.1021/jm981096z
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.0 nM 10.1039/C3MD00247K
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.4 nM 10.1016/j.bmc.2013.08.040
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.6 nM 10.1016/j.bmc.2014.11.032
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6.7 nM 10.1016/j.ejmech.2014.09.054
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 7.0 nM 10.1016/j.bmc.2012.04.030
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 7.0 nM 10.1016/j.bmc.2012.07.026
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 7.0 nM 10.1016/j.ejmech.2012.04.004
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 7.5 nM 10.1016/j.bmc.2011.10.002
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 8.0 nM 10.1021/acs.jmedchem.5b01183
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 8.0 nM 10.1021/acsmedchemlett.7b00361
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 8.1 nM 10.1016/j.bmc.2018.03.003
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 8.2 nM 10.1016/j.ejmech.2016.02.068
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 9.3 nM 10.1128/aac.00068-10
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 10.0 nM 10.1016/j.ejmech.2013.04.052
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 11.0 nM 10.1021/jm00010a008
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 12.0 nM 10.1016/j.ejmech.2014.02.047
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 20.0 nM 10.1016/j.ejmech.2021.113868
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 56.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 67.0 nM 10.1016/j.ejmech.2013.09.047
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 67.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 71.0 nM 10.1128/aac.01004-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 120.0 nM 10.1128/aac.01004-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 129.3 nM 10.1016/j.bmc.2011.05.060
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 490.0 nM 10.1021/acs.jmedchem.5b00737
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 6000.0 nM 10.1021/acs.jnatprod.5b00073
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 35000.0 nM 10.1021/jm00010a008
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 39000.0 nM 10.1016/j.bmc.2011.06.007
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 39000.0 nM 10.1016/j.ejmech.2012.03.032
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 250000.0 nM 10.1021/acs.jmedchem.5b00737
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 nan None 10.1016/j.ejmech.2017.02.047
Human immunodeficiency virus 2 Human immunodeficiency virus 2 Emax 66.0 % 10.1016/j.bmcl.2012.09.108
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 0.00094 ug.mL-1 10.1007/s00044-013-0567-7
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 0.008 ug.mL-1 10.1021/jm960314q
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 0.2 nM 10.1128/aac.01443-09
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 1.0 nM 10.1128/aac.01443-09
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 1.7 nM 10.1016/j.ejmech.2014.05.059
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 5.0 nM 10.1016/j.bmc.2008.11.075
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 6.0 nM 10.1021/np500271u
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 7.0 nM 10.1016/j.bmcl.2013.12.093
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 9.0 nM 10.1016/j.bmcl.2012.09.108
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 40.0 nM 10.1016/j.bmcl.2013.12.093
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 14900.0 nM 10.1016/j.bmcl.2013.12.093
Human immunodeficiency virus 3 Human immunodeficiency virus 3 EC50 40.0 nM 10.1021/jm0400505
Human immunodeficiency virus 3 Human immunodeficiency virus 3 IC50 1872000.0 nM 10.1021/jm0400505
Human T-cell leukemia virus type I Human T-cell leukemia virus type I Activity nan None 10.1021/jm070285r
Human T-cell leukemia virus type I Human T-cell leukemia virus type I IC50 0.16 ug.mL-1 10.1016/j.bmc.2011.01.024
Human T-cell leukemia virus type I Human T-cell leukemia virus type I Inhibition 100.0 % 10.1016/j.bmc.2011.01.024
Human T-cell leukemia virus type I Human T-cell leukemia virus type I MPC 1.0 uM 10.1021/jm070285r
Klebsiella pneumoniae Klebsiella pneumoniae MIC 5000.0 nM 10.6019/CHEMBL4513141
Leishmania donovani Leishmania donovani IC50 3400.0 nM 10.1016/j.bmcl.2006.07.042
Leishmania donovani Leishmania donovani IC50 112260.0 nM 10.6019/CHEMBL3392926
Leishmania donovani Leishmania donovani IC50 374190.0 nM 10.6019/CHEMBL3392926
Macaca mulatta Plasma Fu 0.707 None 10.1124/dmd.110.037457
Macaca mulatta Rhesus monkey F 90.0 % 10.1128/aac.01498-06
Macaca mulatta Rhesus monkey T1/2 0.8 hr 10.1128/aac.01498-06
Moloney murine leukemia virus Moloney murine leukemia virus ED50 0.02 uM 10.1021/jm00385a033
Moloney murine sarcoma virus Moloney murine sarcoma virus IC50 0.02 ug.mL-1 10.1021/jm960314q
Murine leukemia virus Murine leukemia virus MIC50 0.0014 ug.mL-1 10.1021/jm00093a023
Murine leukemia virus Murine leukemia virus TD50 100.0 ug ml-1 10.1021/jm00093a023
Mus musculus 3T3-L1 Activity nan None 10.1128/aac.01505-07
Mus musculus C3H/3T3 EC50 20.0 nM 10.1021/jm00108a028
Mus musculus C3H/3T3 EC50 100000.0 nM 10.1021/jm981096z
Mus musculus Deoxycytidine kinase Activity 84.0 % 10.1021/jm00366a006
Mus musculus Deoxycytidine kinase Activity 89.0 % 10.1021/jm00366a006
Mus musculus FM3A IC50 203000.0 nM 10.1021/jm001121c
Mus musculus Glutathione S-transferase Mu 1 Ratio 2000.0 None 10.1021/jm960802y
Mus musculus L1210 IC50 6180.0 nM 10.1021/jm001121c
Mus musculus L1210/TK- IC50 500000.0 nM 10.1021/jm001121c
Mus musculus L929 Phosphorylation rate 52.0 uM 10.1021/jm0491896
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus AUC 11785000.0 ng.hr.mL-1 10.1021/jm9408326
Mus musculus Mus musculus Brain content 0.0 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Brain content 0.2 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Brain content 2.0 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Brain content 2.5 nM g-1 10.1021/jm00094a018
Mus musculus Mus musculus Brain content 4.9 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Colony_count 10.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Colony_count 14.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Colony_count 47.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Colony_count 70.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Colony_count 74.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Colony_count 85.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Colony_count 109.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Colony_count 141.0 None 10.1021/jm00015a008
Mus musculus Mus musculus Concentration 1.3 ug ml-1 10.1021/jm9408326
Mus musculus Mus musculus Concentration 2.5 ug ml-1 10.1021/jm9408326
Mus musculus Mus musculus Distribution 0.12 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Distribution 0.13 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Distribution 0.14 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Distribution 0.15 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Distribution 0.21 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Distribution 3.4 % 10.1021/jm9408326
Mus musculus Mus musculus Distribution 7.6 % 10.1021/jm9408326
Mus musculus Mus musculus Distribution 9.6 % 10.1021/jm9408326
Mus musculus Mus musculus Distribution 14.6 % 10.1021/jm9408326
Mus musculus Mus musculus Distribution 15.9 % 10.1021/jm9408326
Mus musculus Mus musculus Distribution 51.7 % 10.1021/jm9408326
Mus musculus Mus musculus Distribution 74.5 % 10.1021/jm9408326
Mus musculus Mus musculus EC50 35.0 nM 10.1021/jm00105a064
Mus musculus Mus musculus EC50 46.0 nM 10.1021/jm00105a064
Mus musculus Mus musculus External nucleoside 9750.0 nM g-1 10.1021/jm00094a018
Mus musculus Mus musculus IC50 594000.0 nM 10.1021/jm00105a064
Mus musculus Mus musculus Inhibition 46.0 % 10.1016/S0960-894X(00)80410-2
Mus musculus Mus musculus Inhibition 50.0 % 10.1016/S0960-894X(00)80410-2
Mus musculus Mus musculus Inhibition 78.0 % 10.1016/S0960-894X(00)80410-2
Mus musculus Mus musculus Internalisation 0.03 % 10.1021/jm00094a018
Mus musculus Mus musculus Ki 1330000.0 nM 10.1021/jm9408326
Mus musculus Mus musculus Plasma content 0.0 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 4.4 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 6.0 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 13.1 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 15.7 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 19.1 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 21.7 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 26.6 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 27.5 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 43.2 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Plasma content 48.3 nM ml-1 10.1021/jm00094a018
Mus musculus Mus musculus Quantity 0.48 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Quantity 1.12 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Quantity 10.16 pM mg-1 10.1021/jm9408326
Mus musculus Mus musculus Spleen weight 357.0 mg 10.1016/S0960-894X(00)80410-2
Mus musculus Mus musculus Spleen weight 669.0 mg 10.1016/S0960-894X(00)80410-2
Mus musculus Mus musculus Spleen weight 706.0 mg 10.1016/S0960-894X(00)80410-2
Mus musculus Mus musculus T1/2 0.3917 hr 10.1021/jm9408326
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Plasma Fu 0.896 None 10.1124/dmd.110.037457
Mus musculus Plasma Ratio AUC 0.97 None 10.1124/dmd.110.034629
Mus musculus Solute carrier family 22 member 8 Activity 5.13 % 10.1124/jpet.103.063370
Mus musculus Thymidine kinase, cytosolic Activity 5.0 % 10.1021/jm00366a006
Mus musculus Thymidine kinase, cytosolic Activity 59.0 % 10.1021/jm00366a006
Mycobacterium intracellulare Mycobacterium intracellulare IC50 nan ug.mL-1 10.1021/jm030475b
Mycobacterium intracellulare Mycobacterium intracellulare IC50 nan None 10.1021/np0601399
Mycobacterium sp. Mycobacterium sp. Activity nan None 10.1016/j.bmcl.2015.04.018
Mycobacterium tuberculosis Thymidylate kinase Ki 28000.0 nM 10.1016/j.bmc.2011.10.021
Mycobacterium tuberculosis Thymidylate kinase Ki 28000.0 nM 10.1016/s0960-894x(03)00643-7
Mycobacterium tuberculosis Thymidylate kinase Ki 28000.0 nM 10.1021/jm021108n
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium falciparum Plasmodium falciparum EC50 100000.0 nM 10.1016/j.bmc.2010.07.006
Plasmodium falciparum Plasmodium falciparum GI 0.0 % 10.1016/j.bmc.2010.07.006
Plasmodium falciparum Plasmodium falciparum IC50 20000.0 nM 10.1016/j.bmc.2010.10.009
Plasmodium falciparum Plasmodium falciparum IC50 174750.0 nM 10.6019/CHEMBL3392926
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2012.06.038
Porcine endogenous retrovirus Porcine endogenous retrovirus EC50 23.0 nM 10.1128/aac.00212-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10000.0 nM 10.6019/CHEMBL4513141
Rattus norvegicus 9L IC50 nan nM 10.1021/jm980510s
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Brain Fu 0.95 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Inhibition nan % 10.1021/jm5015296
Rattus norvegicus Brain Kp 1.08 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Vd 1.1 L.kg-1 10.1124/dmd.110.035998
Rattus norvegicus Brain Vdu 1.1 ml 10.1021/jm901036q
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Fatty acid synthase Activity 0.55 U/mg 10.1128/aac.01078-06
Rattus norvegicus Fatty acid synthase Activity 0.72 U/mg 10.1128/aac.01078-06
Rattus norvegicus Fatty acid synthase Activity nan None 10.1128/aac.01078-06
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus H9c2 Activity nan None 10.1128/aac.00039-07
Rattus norvegicus Heart IC50 24400.0 nM 10.1128/aac.01227-06
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver Activity nan None 10.1021/jm5015296
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Peripheral myelin protein 22 Potency 25574.8 nM None
Rattus norvegicus Plasma Cp(f) 1.2 uM 10.1021/jm901036q
Rattus norvegicus Plasma Fu 0.64 None 10.1021/jm901036q
Rattus norvegicus Plasma Fu 0.734 None 10.1124/dmd.110.037457
Rattus norvegicus Plasma K(p,uu,CSF) 0.18 None 10.1021/jm901036q
Rattus norvegicus Rattus norvegicus Activity 0.27 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 0.32 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 0.43 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 0.6 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 1.66 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 1.79 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 1.96 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 2.11 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 3.86 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 8.35 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 35.4 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 59.5 mM 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 401.0 g 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 443.0 g 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 625.0 ug 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity 2082.0 um2 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus Activity nan None 10.1128/aac.01078-06
Rattus norvegicus Rattus norvegicus ALB 39000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 387.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 450.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 470.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 476.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 62.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 69.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 73.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 86.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 112.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 120.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 653.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 680.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 726.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 753.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 263.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 317.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 377.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 517.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Distribution 22.8 % 10.1021/jm9408326
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 94.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1546.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1563.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1616.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1623.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 31.23 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.23 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.13 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 127700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 132700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 132.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 138.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 179.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 235.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11829.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12442.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12857.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15346.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 86.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.23 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.3 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.67 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.83 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 392300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 399700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 404700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 409000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.13 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.37 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.27 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 82.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 183.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 401.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 4.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 541.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 955.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1349.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2019.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 107.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1138330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1215670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1228000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1253000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.46 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.54 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.64 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.72 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4950000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5260000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5270000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5550000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.47 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 19.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12870.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14300.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 17770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Solute carrier family 22 member 1 Activity nan None 10.1016/s0006-2952(00)00334-8
Rattus norvegicus Solute carrier family 22 member 2 Activity nan None 10.1016/s0006-2952(00)00334-8
Rattus norvegicus Solute carrier family 22 member 6 Km 68000.0 nM None
Rattus norvegicus Solute carrier family 22 member 7 Km 26000.0 nM None
Rattus norvegicus Solute carrier family 22 member 8 Activity nan None 10.1074/jbc.274.19.13675
Rattus norvegicus Solute carrier organic anion transporter family member 1A3 Km 64300.0 nM None
Rattus norvegicus Solute carrier organic anion transporter family member 1A3 Km 76300.0 nM None
Rattus norvegicus Thymidine kinase Phosphorylation rate 4.0 uM 10.1021/jm0491896
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rauscher murine leukemia virus Rauscher murine leukemia virus IC50 23.0 nM 10.1021/jm00128a034
Rauscher murine leukemia virus Rauscher murine leukemia virus ID50 0.001 ug ml-1 10.1021/jm00166a019
Rauscher murine leukemia virus Rauscher murine leukemia virus TCID50 400.0 uM 10.1021/jm00128a034
Rotavirus Rotavirus IC50 6.0 ug.mL-1 10.1016/j.bmc.2007.02.031
Rotavirus Rotavirus IC50 20.0 ug.mL-1 10.1016/j.bmc.2007.02.031
Rotavirus Rotavirus IC50 22390.0 nM 10.1016/j.bmc.2007.05.055
Rotavirus Rotavirus IC50 22450.0 nM 10.1016/j.bmc.2007.02.031
Rotavirus Rotavirus IC50 22450.0 nM 10.1016/j.ejmech.2007.04.001
Rotavirus Rotavirus IC50 22450.0 nM 10.1016/j.ejmech.2007.10.014
Rotavirus Rotavirus IC50 74620.0 nM 10.1016/j.bmc.2007.05.055
Rotavirus Rotavirus IC50 74840.0 nM 10.1016/j.bmc.2007.02.031
Rotavirus Rotavirus IC50 74840.0 nM 10.1016/j.ejmech.2007.04.001
Rotavirus Rotavirus IC50 74840.0 nM 10.1016/j.ejmech.2007.10.014
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 100000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.05623 None 10.1101/2020.04.03.023846
Simian immunodeficiency virus Simian immunodeficiency virus EC50 11.0 nM 10.1128/aac.00210-08
Simian immunodeficiency virus Simian immunodeficiency virus EC50 12.2 nM 10.1016/j.bmc.2006.09.062
Simian immunodeficiency virus Simian immunodeficiency virus IC50 0.5 nM 10.1128/aac.01443-09
Simian immunodeficiency virus Simian immunodeficiency virus IC50 10.0 nM 10.1128/aac.01443-09
Staphylococcus aureus Staphylococcus aureus IC50 nan ug.mL-1 10.1021/jm030475b
Staphylococcus aureus Staphylococcus aureus IC50 nan None 10.1021/np0601399
Staphylococcus aureus Staphylococcus aureus MIC 10000.0 nM 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 316000.0 nM 10.1128/aac.00081-07
Staphylococcus aureus Thymidine kinase Kcat 1.48 /s 10.1128/aac.00081-07
Staphylococcus aureus Thymidine kinase Kcat/Km 1.29 10'5/M/s 10.1128/aac.00081-07
Staphylococcus aureus Thymidine kinase Ki 944000.0 nM 10.1128/aac.00081-07
Staphylococcus aureus Thymidine kinase Km 11600.0 nM 10.1128/aac.00081-07
Staphylococcus aureus Thymidine kinase Vmax 4.0 U/mg 10.1128/aac.00081-07
Streptococcus pyogenes Streptococcus pyogenes MIC nan None 10.1128/aac.00081-07
Streptococcus sp. Streptococcus sp. MIC 316000.0 nM 10.1128/aac.00081-07
Trypanosoma brucei 6-phospho-1-fructokinase Potency 849.2 nM None
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 139570.0 nM 10.6019/CHEMBL3392926
Trypanosoma cruzi Trypanosoma cruzi IC50 155660.0 nM 10.6019/CHEMBL3392926
Ureaplasma parvum serovar 3 (strain ATCC 700970) Thymidine kinase Activity 27.8 % 10.1016/j.bmc.2010.03.023
Ureaplasma parvum serovar 3 (strain ATCC 700970) Thymidine kinase Activity 43.0 % 10.1016/j.bmc.2010.03.023
Ureaplasma parvum serovar 3 (strain ATCC 700970) Thymidine kinase IC50 12500.0 nM 10.1016/j.bmc.2010.03.023
Ureaplasma parvum serovar 3 (strain ATCC 700970) Thymidine kinase Km 2700.0 nM 10.1016/j.bmc.2010.03.023
Ureaplasma parvum serovar 3 (strain ATCC 700970) Thymidine kinase Ratio 281.0 /min.mg 10.1016/j.bmc.2010.03.023
Ureaplasma parvum serovar 3 (strain ATCC 700970) Thymidine kinase Vmax 760.0 nmol/mg.min 10.1016/j.bmc.2010.03.023
Visna-maedi virus Visna-maedi virus MIC 5600.0 nM 10.1021/jm00062a006
West Nile virus West Nile virus Inhibition 0.0 % 10.1021/acs.jmedchem.5b00327
None ADMET Activity 35.0 % 10.1128/aac.01115-08
None ADMET Activity 40.0 % 10.1128/aac.00914-09
None ADMET Activity 83.0 % 10.1021/acs.jmedchem.5b00327
None ADMET Activity 89.0 % 10.1021/acs.jmedchem.5b00327
None ADMET Activity 100.0 % 10.1016/j.bmcl.2014.04.073
None ADMET Activity 100.0 % 10.1016/j.bmcl.2014.12.047
None ADMET Activity nan None 10.1016/j.ejmech.2011.05.051
None ADMET Activity nan None 10.1128/aac.00039-07
None ADMET Activity nan None 10.1128/aac.00068-10
None ADMET Activity nan None 10.1128/aac.00434-08
None ADMET Activity nan None 10.1128/aac.00914-09
None ADMET Activity nan None 10.1128/aac.01115-08
None ADMET Activity nan None 10.1128/aac.01505-07
None ADMET AUC 1210.0 ng.hr.mL-1 10.1021/jm00170a023
None ADMET AUC 11280.0 ng.hr.mL-1 10.1021/jm00170a023
None ADMET AUC 25380.0 ng.hr.mL-1 10.1021/jm00170a023
None ADMET AUC 26640.0 ng.hr.mL-1 10.1021/jm00170a023
None ADMET AUC 174700.0 ng.hr.mL-1 10.1021/jm950620o
None ADMET BFU 4.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 46.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 59.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 76.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 79.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 88.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 120.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 132.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU 143.0 None 10.1016/S0960-894X(00)80410-2
None ADMET BFU nan None 10.1016/S0960-894X(00)80410-2
None ADMET BPR 0.065 None 10.1021/jm901036q
None ADMET CC50 3.24 ug.mL-1 10.1016/j.bmc.2011.01.024
None ADMET CC50 200.0 ug.mL-1 10.1016/j.bmcl.2010.12.055
None ADMET CC50 500.0 nM 10.1128/aac.00068-10
None ADMET CC50 890.0 nM 10.1128/aac.00068-10
None ADMET CC50 7480.0 nM 10.1016/j.bmc.2021.116531
None ADMET CC50 8000.0 nM 10.1021/jm001033s
None ADMET CC50 10000.0 nM 10.1021/jm00033a018
None ADMET CC50 10000.0 nM 10.1021/jm00062a027
None ADMET CC50 10000.0 nM 10.1128/aac.00212-07
None ADMET CC50 10000.0 nM 10.1128/aac.00277-07
None ADMET CC50 11000.0 nM 10.1021/jm001033s
None ADMET CC50 26000.0 nM 10.1021/jm00103a009
None ADMET CC50 75000.0 nM 10.1021/jm991125l
None ADMET CC50 100000.0 nM 10.1016/0960-894X(95)00302-A
None ADMET CC50 100000.0 nM 10.1016/j.bmc.2015.06.020
None ADMET CC50 100000.0 nM 10.1016/j.bmcl.2014.04.073
None ADMET CC50 100000.0 nM 10.1016/j.bmcl.2014.12.047
None ADMET CC50 100000.0 nM 10.1016/s0960-894x(99)00624-1
None ADMET CC50 100000.0 nM 10.1021/jm050257d
None ADMET CC50 100000.0 nM 10.1128/aac.01064-10
None ADMET CC50 100000.0 nM 10.1128/aac.01241-07
None ADMET CC50 149000.0 nM 10.1021/jm9607921
None ADMET CC50 200000.0 nM 10.1021/jm2001103
None ADMET CC50 250000.0 nM 10.1021/acs.jmedchem.5b00737
None ADMET CC50 270000.0 nM 10.1128/aac.00392-09
None ADMET CC50 400000.0 nM 10.1021/jm060030y
None ADMET CC50 467700.0 nM 10.1016/j.bmcl.2013.12.093
None ADMET CC50 100000000.0 nM 10.1021/jm960694f
None ADMET CC50 nan nM 10.1016/s0960-894x(01)00323-7
None ADMET CC50 nan None 10.1016/j.bmcl.2011.12.076
None ADMET CC90 200.0 uM 10.1021/jm2001103
None ADMET CFU 0.0 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU 1.0 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU 4.3 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU 4.5 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU 4.7 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU 10.7 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU 18.7 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU 33.4 None 10.1016/S0960-894X(00)80410-2
None ADMET CFU nan None 10.1016/S0960-894X(00)80410-2
None ADMET CL 14.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 15.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 24.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 25.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 46.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET Concentration 1.0 ug ml-1 10.1021/jm9408326
None ADMET delta logD nan None 10.1021/jm0000564
None ADMET Drug uptake 5.88 % 10.1128/aac.01209-09
None ADMET Drug uptake 6.24 % 10.1128/aac.01209-09
None ADMET Drug uptake 6.74 % 10.1128/aac.01209-09
None ADMET Drug uptake 61.15 % 10.1128/aac.01209-09
None ADMET Drug uptake 61.87 % 10.1128/aac.01209-09
None ADMET Drug uptake 62.89 % 10.1128/aac.01209-09
None ADMET Drug uptake 557.0 ng/ml 10.1128/aac.01523-08
None ADMET Drug uptake 605.0 ng/ml 10.1128/aac.01523-08
None ADMET Drug uptake 2249.0 ng/ml 10.1128/aac.01523-08
None ADMET Drug uptake nan None 10.1128/aac.01064-10
None ADMET EC50 1.0 nM 10.1021/jm991125l
None ADMET EC50 1.2 nM 10.1021/jm00089a007
None ADMET EC50 1.4 nM 10.1021/jm00103a009
None ADMET EC50 2.0 nM 10.1016/j.bmcl.2004.02.031
None ADMET EC50 2.0 nM 10.1021/jm00115a022
None ADMET EC50 2.0 nM 10.1021/jm00123a018
None ADMET EC50 3.0 nM 10.1021/jm00015a008
None ADMET EC50 3.0 nM 10.1021/jm0300274
None ADMET EC50 4.0 nM 10.1016/0960-894X(95)00107-5
None ADMET EC50 4.0 nM 10.1016/0960-894X(95)00133-E
None ADMET EC50 4.0 nM 10.1016/0960-894X(96)00171-0
None ADMET EC50 4.0 nM 10.1016/0960-894X(96)00210-7
None ADMET EC50 4.0 nM 10.1016/S0960-894X(01)80266-3
None ADMET EC50 4.0 nM 10.1016/s0960-894x(98)00278-9
None ADMET EC50 4.0 nM 10.1021/jm00053a004
None ADMET EC50 4.0 nM 10.1021/jm00115a022
None ADMET EC50 4.0 nM 10.1021/jm010418n
None ADMET EC50 4.0 nM 10.1021/jm020246+
None ADMET EC50 4.0 nM 10.1021/jm020376i
None ADMET EC50 4.0 nM 10.1021/jm970275y
None ADMET EC50 5.0 nM 10.1021/jm010418n
None ADMET EC50 6.0 nM 10.1021/jm991125l
None ADMET EC50 9.0 nM 10.1021/jm00089a007
None ADMET EC50 9.0 nM 10.1021/jm9607921
None ADMET EC50 10.0 nM 10.1021/jm0300274
None ADMET EC50 11.35 nM 10.1016/j.bmcl.2010.12.003
None ADMET EC50 80.0 nM 10.1016/0960-894X(95)00302-A
None ADMET EC50 1200.0 nM 10.1021/jm00089a007
None ADMET EC50 2000.0 nM 10.1021/jm00170a023
None ADMET EC50 50000.0 ug.mL-1 10.1021/np970497z
None ADMET EC50 80000.0 nM 10.1021/jm960694f
None ADMET EC50 100000.0 nM 10.1021/jm010418n
None ADMET EC50 1000000.0 nM 10.1016/s0960-894x(99)00581-8
None ADMET EC50 1000000.0 nM 10.1021/jm00089a007
None ADMET EC90 0.003 uM 10.1021/jm020246+
None ADMET EC90 0.0065 uM 10.1021/jm00089a007
None ADMET EC90 0.01 uM 10.1021/jm020246+
None ADMET EC90 0.02 uM 10.1016/j.bmcl.2004.02.031
None ADMET EC90 0.025 uM 10.1021/jm0300274
None ADMET EC90 19.0 uM 10.1021/jm00089a007
None ADMET EC90 2923.0 uM 10.1021/jm00089a007
None ADMET EC90 nan None 10.1016/s0960-894x(98)00278-9
None ADMET ED50 0.04 uM 10.1021/jm970443m
None ADMET F 79.0 % 10.1021/jm0000564
None ADMET Fm 0.02 None 10.1124/dmd.110.037457
None ADMET Fm 0.034 None 10.1124/dmd.110.037457
None ADMET Fm 0.08 None 10.1124/dmd.110.037457
None ADMET Fm 0.134 None 10.1124/dmd.110.037457
None ADMET Fm 0.85 None 10.1124/dmd.110.037457
None ADMET Fu 0.77 None 10.1021/jm030408h
None ADMET IC50 1.0 nM 10.1021/jm010212m
None ADMET IC50 2.0 nM 10.1021/jm010212m
None ADMET IC50 4.0 nM 10.1016/s0960-894x(98)00250-9
None ADMET IC50 4.0 nM 10.1016/s0960-894x(99)00235-8
None ADMET IC50 4.0 nM 10.1016/s0960-894x(99)00460-6
None ADMET IC50 4.0 nM 10.1016/s0960-894x(99)00624-1
None ADMET IC50 4.0 nM 10.1021/jm010212m
None ADMET IC50 6.0 nM 10.1016/s0960-894x(98)00384-9
None ADMET IC50 6.0 nM 10.1016/s0960-894x(99)00235-8
None ADMET IC50 6.0 nM 10.1016/s0960-894x(99)00460-6
None ADMET IC50 6.0 nM 10.1016/s0960-894x(99)00624-1
None ADMET IC50 7.0 nM 10.1021/jm010212m
None ADMET IC50 9.0 nM 10.1021/jm010212m
None ADMET IC50 25.0 nM 10.1021/jm010212m
None ADMET IC50 100.0 nM 10.1128/aac.01443-09
None ADMET IC50 150.0 nM 10.1016/s0960-894x(99)00235-8
None ADMET IC50 200.0 nM 10.1016/s0960-894x(99)00460-6
None ADMET IC50 200.0 nM 10.1016/s0960-894x(99)00624-1
None ADMET IC50 600.0 nM 10.1021/jm00042a011
None ADMET IC50 2000.0 nM 10.1016/s0960-894x(98)00547-2
None ADMET IC50 2400.0 nM 10.1016/s0960-894x(98)00547-2
None ADMET IC50 14300.0 nM 10.1021/jm0303148
None ADMET IC50 29000.0 nM 10.1021/jm0303148
None ADMET IC50 50000.0 nM 10.1016/s0960-894x(98)00384-9
None ADMET IC50 100000.0 nM 10.1016/0960-894X(95)00107-5
None ADMET IC50 100000.0 nM 10.1016/0960-894X(95)00133-E
None ADMET IC50 100000.0 nM 10.1016/0960-894X(96)00171-0
None ADMET IC50 100000.0 nM 10.1016/0960-894X(96)00210-7
None ADMET IC50 100000.0 nM 10.1016/j.bmc.2006.10.043
None ADMET IC50 100000.0 nM 10.1016/j.bmcl.2004.02.031
None ADMET IC50 100000.0 nM 10.1016/S0960-894X(01)80266-3
None ADMET IC50 100000.0 nM 10.1016/s0960-894x(98)00250-9
None ADMET IC50 100000.0 nM 10.1016/s0960-894x(98)00278-9
None ADMET IC50 100000.0 nM 10.1021/jm00053a004
None ADMET IC50 100000.0 nM 10.1021/jm00057a001
None ADMET IC50 100000.0 nM 10.1021/jm00089a007
None ADMET IC50 100000.0 nM 10.1021/jm00115a022
None ADMET IC50 100000.0 nM 10.1021/jm010256v
None ADMET IC50 100000.0 nM 10.1021/jm020246+
None ADMET IC50 100000.0 nM 10.1021/jm020376i
None ADMET IC50 100000.0 nM 10.1021/jm0303148
None ADMET IC50 100000.0 nM 10.1021/jm970275y
None ADMET IC50 100000.0 nM 10.1021/jm980510s
None ADMET IC50 200000.0 nM 10.1016/j.bmcl.2015.04.018
None ADMET IC50 200000.0 nM 10.1021/jm00123a018
None ADMET IC50 10000000.0 nM 10.1021/np3006887
None ADMET ID50 1.0 uM 10.1021/jm00122a029
None ADMET ID50 6.7 uM 10.1021/jm00122a029
None ADMET ID50 1517.0 uM 10.1021/np50082a020
None ADMET ID90 20.0 uM 10.1021/jm00122a029
None ADMET Inhibition 0.0 % 10.1021/jm00028a013
None ADMET Inhibition 2.0 % 10.1021/jm00028a013
None ADMET Inhibition 81.0 % 10.1021/jm00028a013
None ADMET Inhibition 90.0 % 10.1021/jm00028a013
None ADMET K(p,uu,brain) 0.09 None 10.1021/jm901036q
None ADMET LC50 89500.0 nM 10.1021/np400847t
None ADMET MIC 400000.0 nM 10.1021/jm00108a028
None ADMET MRT 1.2 hr 10.1124/dmd.108.020479
None ADMET p24 12.0 pg ml-1 10.1021/jm00016a002
None ADMET p24 13.0 pg ml-1 10.1021/jm00016a002
None ADMET p24 18.0 pg ml-1 10.1021/jm00016a002
None ADMET p24 22.0 pg ml-1 10.1021/jm00016a002
None ADMET p24 8070.0 pg ml-1 10.1021/jm00016a002
None ADMET p24 8218.0 pg ml-1 10.1021/jm00016a002
None ADMET p24 9299.0 pg ml-1 10.1021/jm00016a002
None ADMET p24 9338.0 pg ml-1 10.1021/jm00016a002
None ADMET Papp 6.7 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 7.1 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 7.4 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 9.6 ucm/s 10.1124/dmd.110.034629
None ADMET Ratio 0.86 None 10.1128/aac.01523-08
None ADMET Ratio 1.0 None 10.1124/dmd.110.034629
None ADMET Ratio 1.14 None 10.1128/aac.00434-08
None ADMET Ratio 1.4 None 10.1124/dmd.110.034629
None ADMET Ratio 1.45 None 10.1128/aac.00434-08
None ADMET Ratio 4.2 None 10.1128/aac.01523-08
None ADMET Ratio 10.0 None 10.1124/dmd.110.034629
None ADMET Ratio 19.0 None 10.1021/jm00391a003
None ADMET Ratio 26.0 None 10.1124/dmd.110.034629
None ADMET Ratio 33.0 None 10.1124/dmd.110.034629
None ADMET Ratio 410.0 None 10.1016/s0960-894x(00)00535-7
None ADMET Ratio 526.32 None 10.1021/jm801395v
None ADMET Ratio 4000.0 None 10.1016/s0960-894x(00)00535-7
None ADMET Ratio 41622.0 None 10.1016/s0960-894x(00)00635-1
None ADMET Ratio CC50/EC50 18.8 None 10.1016/j.bmcl.2014.04.073
None ADMET Ratio CC50/EC50 18.8 None 10.1016/j.bmcl.2014.12.047
None ADMET Ratio CC50/EC50 19.0 None 10.1016/j.bmc.2019.07.047
None ADMET Ratio CC50/EC50 22.9 None 10.1016/j.bmc.2010.12.031
None ADMET Ratio CC50/EC50 37.0 None 10.1016/j.bmcl.2019.05.016
None ADMET Ratio CC50/EC50 48.0 None 10.1021/jm401232v
None ADMET Ratio CC50/EC50 309.0 None 10.1016/j.ejmech.2022.114512
None ADMET Ratio CC50/EC50 352.0 None 10.1016/j.bmc.2021.116531
None ADMET Ratio CC50/EC50 352.0 None 10.1016/j.ejmech.2022.114471
None ADMET Ratio CC50/EC50 410.0 None 10.1016/j.ejmech.2020.113063
None ADMET Ratio CC50/EC50 1004.0 None 10.1016/j.ejmech.2020.113063
None ADMET Ratio CC50/EC50 5170.0 None 10.1016/j.ejmech.2019.01.020
None ADMET Ratio CC50/EC50 5881.0 None 10.1021/np300395m
None ADMET Ratio CC50/EC50 5881.0 None 10.1021/np300727f
None ADMET Ratio CC50/EC50 5882.0 None 10.1021/np400070x
None ADMET Ratio CC50/EC50 8235.0 None 10.1016/j.ejmech.2021.113315
None ADMET Ratio CC50/EC50 12221.0 None 10.1039/C3MD00028A
None ADMET Ratio CC50/EC50 40000.0 None 10.1016/j.ejmech.2021.113315
None ADMET Ratio CC50/EC50 46511.6 None 10.1021/np300745q
None ADMET Ratio CC50/EC50 56907.0 None 10.1039/C3MD00028A
None ADMET Ratio CC50/EC50 60606.1 None 10.1016/j.bmcl.2010.12.055
None ADMET Ratio CC50/EC50 167124.06 None 10.1021/acs.jnatprod.1c00896
None ADMET Ratio CC50/EC50 214331.0 None 10.1021/np200146x
None ADMET Ratio CC50/EC50 215627.0 None 10.1016/j.ejmech.2012.03.032
None ADMET Ratio CC50/EC50 230000.0 None 10.1021/acs.jnatprod.5b00392
None ADMET Ratio CC50/EC50 274200.0 None 10.1016/j.bmcl.2012.09.070
None ADMET Ratio CC50/EC50 286250.0 None 10.1016/j.bmcl.2010.06.056
None ADMET Ratio CC50/EC50 337605.3 None 10.1021/acs.jnatprod.8b00243
None ADMET Ratio CC50/EC50 352688.27 None 10.1016/j.bmcl.2010.04.132
None ADMET Ratio CC50/EC50 422067.0 None 10.1016/j.ejmech.2012.03.032
None ADMET Ratio CC50/EC50 460505.88 None 10.1016/j.bmcl.2016.11.030
None ADMET Ratio CC50/EC50 473128.45 None 10.1021/jm301226a
None ADMET Ratio CC50/EC50 588644.0 None 10.1016/j.bmc.2016.03.043
None ADMET Ratio CC50/EC50 1017500.0 None 10.1021/np200058c
None ADMET Ratio CC50/EC50 1017500.0 None 10.1021/np200087d
None ADMET Ratio CC50/IC50 23.07 None 10.1016/j.bmc.2010.03.015
None ADMET Ratio CC50/IC50 235.54 None 10.1016/j.ejmech.2018.07.067
None ADMET Ratio CC50/IC50 1089.48 None 10.1016/j.ejmech.2019.111699
None ADMET Ratio CC50/IC50 1248.0 None 10.1021/jm301040s
None ADMET Ratio CC50/IC50 5556.0 None 10.1021/jm0508890
None ADMET Ratio CC50/IC50 7143.0 None 10.1021/jm0508890
None ADMET Ratio CC50/IC50 21420.0 None 10.1016/j.ejmech.2019.111714
None ADMET Ratio CC50/IC50 29067.0 None 10.1016/j.ejmech.2019.111714
None ADMET Ratio CC50/IC50 32296.0 None 10.1016/j.ejmech.2019.111714
None ADMET Ratio CC50/IC50 43600.0 None 10.1016/j.ejmech.2019.111714
None ADMET Ratio CC50/IC50 54500.0 None 10.1016/j.ejmech.2019.111714
None ADMET Ratio IC50/EC50 2.1 None 10.1021/acs.jnatprod.2c00980
None ADMET Ratio IC50/EC50 41.67 None 10.1021/np990281s
None ADMET Ratio IC50/EC50 50.86 None 10.1016/j.ejmech.2010.05.060
None ADMET Ratio IC50/EC50 36520.0 None 10.1016/j.bmcl.2007.05.026
None ADMET Ratio IC50/EC50 38000.0 None 10.1016/j.bmc.2006.12.013
None ADMET Ratio IC50/EC50 41667.0 None 10.1021/np0101189
None ADMET Ratio IC50/EC50 41667.0 None 10.1021/np060124a
None ADMET Ratio IC50/EC50 41667.0 None 10.1021/np9800710
None ADMET Ratio IC50/EC50 41667.0 None 10.1021/np990633v
None ADMET Ratio IC50/EC50 42700.0 None 10.1016/j.bmc.2010.04.089
None ADMET Ratio IC50/EC50 50000.0 None 10.1021/np50104a008
None ADMET Ratio IC50/EC50 55000.0 None 10.1021/jm901782m
None ADMET Ratio IC50/EC50 55330.0 None 10.1016/j.bmcl.2007.09.081
None ADMET Ratio IC50/EC50 80900.0 None 10.1021/np060239e
None ADMET Ratio IC50/EC50 173000.0 None 10.1021/np010211x
None ADMET Rel brain exposure 9.32 None 10.1021/jm00170a023
None ADMET Retention time 12.22 min 10.1021/jm0491896
None ADMET Selectivity Index 240.0 None 10.1016/j.ejmech.2021.113868
None ADMET Selectivity Index 352.0 None 10.1016/j.bmc.2021.116239
None ADMET T 1027.0 None 10.1021/jm950620o
None ADMET T1/2 0.28 hr 10.1021/jm950620o
None ADMET T1/2 0.54 hr 10.1021/jm00170a023
None ADMET T1/2 1.3 hr 10.1124/dmd.108.020479
None ADMET T1/2 2.483 hr 10.1021/jm9408326
None ADMET T1/2 15.8 hr 10.1021/jm00170a023
None ADMET T1/2 nan hr 10.1021/jm981096z
None ADMET T1/2 nan hr 10.1021/jm981097r
None ADMET TC50 78.0 uM 10.1021/jm9004253
None ADMET TC50 100.0 uM 10.1016/j.bmc.2006.09.062
None ADMET TC50 170.0 uM 10.1021/jm010212m
None ADMET TC50 172.0 uM 10.1021/jm010212m
None ADMET TC50 180.0 uM 10.1021/jm010212m
None ADMET TC50 190.0 uM 10.1021/jm010212m
None ADMET TC50 200.0 uM 10.1021/jm010212m
None ADMET TC50 1000.0 uM 10.1016/0960-894X(96)00334-4
None ADMET Therapeutic index 4.17 None 10.1021/jm9900624
None ADMET Therapeutic index 263.0 None 10.1021/jm9900624
None ADMET Therapeutic index 22600.0 None 10.1016/s0960-894x(03)00197-5
None ADMET Therapeutic index 41667.0 None 10.1016/S0960-894X(97)10050-6
None ADMET Therapeutic index 55556.0 None 10.1016/S0960-894X(97)10108-1
None ADMET TI 4.17 None 10.1021/jm000070g
None ADMET TI 7.14 TD50/MIC50 10.1021/jm00093a023
None ADMET TI 22.0 None 10.1021/acs.jnatprod.2c00752
None ADMET TI 22.91 None 10.1016/j.ejmech.2011.01.016
None ADMET TI 23.07 None 10.1016/j.bmcl.2010.06.052
None ADMET TI 50.0 None 10.1016/j.bmc.2017.03.061
None ADMET TI 55.6 None 10.1128/aac.01448-09
None ADMET TI 100.0 None 10.1016/j.bmc.2017.03.061
None ADMET TI 111.0 None 10.1016/j.bmc.2017.03.061
None ADMET TI 125.0 None 10.1016/j.bmcl.2012.07.037
None ADMET TI 250.0 None 10.1016/j.bmcl.2012.07.037
None ADMET TI 375.0 None 10.1021/jm0400505
None ADMET TI 1000.0 None 10.1021/np0003995
None ADMET TI 1385.0 None 10.1016/j.bmc.2010.06.092
None ADMET TI 1780.0 None 10.1021/jm950797i
None ADMET TI 3236.0 None 10.1021/jm950797i
None ADMET TI 5960.0 None 10.1021/jm950797i
None ADMET TI 10000.0 None 10.1021/jm00051a006
None ADMET TI 10000.0 None 10.1021/jm030416y
None ADMET TI 12500.0 None 10.1016/S0960-894X(01)80161-X
None ADMET TI 13113.0 None 10.1021/jm950797i
None ADMET TI 33333.0 None 10.1016/s0960-894x(98)00202-9
None ADMET TI 33333.0 None 10.1021/jm980391g
None ADMET TI 33392.0 None 10.1021/jm900136j
None ADMET TI 39000.0 None 10.1016/j.bmcl.2004.09.032
None ADMET TI 41667.0 None 10.1016/s0960-894x(00)00126-8
None ADMET TI 41667.0 None 10.1016/s0960-894x(01)00437-1
None ADMET TI 41667.0 None 10.1016/s0960-894x(98)00254-6
None ADMET TI 41667.0 None 10.1016/s0960-894x(98)00708-2
None ADMET TI 41667.0 None 10.1021/np980291d
None ADMET TI 41700.0 None 10.1016/j.bmcl.2004.03.051
None ADMET TI 42700.0 None 10.1021/jm0400505
None ADMET TI 43848.0 None 10.1016/j.bmc.2010.08.031
None ADMET TI 50000.0 None 10.1016/s0960-894x(01)00647-3
None ADMET TI 250000.0 None 10.1021/np9601667
None ADMET TI 302096.0 None 10.1016/j.bmcl.2004.09.033
None ADMET TI 471481.0 None 10.1016/j.bmcl.2007.06.008
None ADMET TI50 50.59 None 10.1021/jm000038m
None ADMET Vdss 1.0 L.kg-1 10.1002/jps.20373
None ADMET Vdss 1.6 L.kg-1 10.1002/jps.20373
None ADMET Vdss 1.66 mL/min/kg 10.1002/jps.20373
None ADMET Vdss 1.7 L.kg-1 10.1021/jm030408h
None ADMET Vdss 1.8 L.kg-1 10.1124/dmd.108.020479
None B(EBV+) EC50 1.0 nM 10.1021/jm00045a008
None BxT EC50 55.0 nM 10.1021/jm00045a008
None CFU-GM IC50 1500.0 nM 10.1021/jm00042a011
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 5.1 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.9 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 4.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 5.7 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity LTKB_BD DILI severity score 8.0 None 10.1016/j.drudis.2011.05.007
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 12.7 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 4.8 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None M EC50 15.0 nM 10.1021/jm00045a008
None Molecular identity unknown Inhibition nan % 10.1016/j.ejmech.2016.01.014
None Molecular identity unknown Potency 39810.7 nM None
None Molecular identity unknown Potency 70794.6 nM None
None NON-PROTEIN TARGET Activity 30.0 % 10.1128/aac.01505-07
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.01505-07
None NON-PROTEIN TARGET CC100 500.0 uM 10.1021/jm00086a013
None NON-PROTEIN TARGET CC100 3300.0 uM 10.1021/jm00086a013
None NON-PROTEIN TARGET CC25 4.0 uM 10.1021/jm00086a013
None NON-PROTEIN TARGET CC25 825.0 uM 10.1021/jm00086a013
None NON-PROTEIN TARGET CC50 25.0 ug.mL-1 10.1016/j.bmc.2016.08.029
None NON-PROTEIN TARGET CC50 25.0 ug.mL-1 10.1016/j.ejmech.2016.05.017
None NON-PROTEIN TARGET CC50 7800.0 nM 10.1021/jm00103a009
None NON-PROTEIN TARGET CC50 20000.0 nM 10.1016/0960-894X(96)00433-7
None NON-PROTEIN TARGET CC50 45000.0 nM 10.1021/jm00001a001
None NON-PROTEIN TARGET CC50 93500.0 nM 10.1016/j.ejmech.2016.05.054
None NON-PROTEIN TARGET CC50 93550.0 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET CC50 100000.0 nM 10.1016/s0960-894x(99)00460-6
None NON-PROTEIN TARGET CC50 5858850.0 nM 10.1016/j.bmcl.2016.11.030
None NON-PROTEIN TARGET EC50 0.00094 ug.mL-1 10.1016/j.ejmech.2016.05.017
None NON-PROTEIN TARGET EC50 0.0022 ug.mL-1 10.1016/j.ejmech.2016.05.017
None NON-PROTEIN TARGET EC50 0.7 nM 10.1021/jm000038m
None NON-PROTEIN TARGET EC50 3.8 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 4.8 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 5.2 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 5.8 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 6.0 nM 10.1016/j.ejmech.2016.05.054
None NON-PROTEIN TARGET EC50 6.0 nM 10.1021/jm00080a020
None NON-PROTEIN TARGET EC50 6.3 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 6.6 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 6.7 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 7.0 nM 10.1016/j.ejmech.2016.05.054
None NON-PROTEIN TARGET EC50 7.3 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 10.0 nM 10.1021/acs.jmedchem.6b00738
None NON-PROTEIN TARGET EC50 13.0 nM 10.1016/j.bmcl.2016.11.030
None NON-PROTEIN TARGET EC50 580.0 nM 10.1016/j.ejmech.2008.01.011
None NON-PROTEIN TARGET EC50 nan None 10.1021/acs.jnatprod.5b00073
None NON-PROTEIN TARGET Fu 0.8 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 12.5 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 26.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 44.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 0.00094 ug.mL-1 10.1016/j.bmc.2016.08.029
None NON-PROTEIN TARGET IC50 0.0022 ug.mL-1 10.1016/j.bmc.2016.08.029
None NON-PROTEIN TARGET IC50 1.0 ug.mL-1 10.1016/s0960-894x(98)00122-x
None NON-PROTEIN TARGET IC50 4.0 ug.mL-1 10.1016/j.bmc.2006.10.033
None NON-PROTEIN TARGET IC50 11.0 nM 10.1021/jm900275m
None NON-PROTEIN TARGET IC50 12.0 nM 10.1021/jm900275m
None NON-PROTEIN TARGET IC50 60.0 ug.mL-1 10.1016/j.bmc.2006.10.033
None NON-PROTEIN TARGET IC50 69.0 nM 10.1021/jm9004253
None NON-PROTEIN TARGET IC50 80.0 nM 10.1021/jm00086a013
None NON-PROTEIN TARGET IC50 6810.0 nM 10.1016/j.bmc.2014.09.046
None NON-PROTEIN TARGET IC50 9170.0 nM 10.1016/j.bmc.2014.09.046
None NON-PROTEIN TARGET IC50 37500.0 nM 10.1021/jm0400505
None NON-PROTEIN TARGET IC50 112260.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 206930.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET ID50 0.1 ug ml-1 10.1021/jm00170a017
None NON-PROTEIN TARGET MIC 20.0 nM 10.1016/0960-894X(96)00433-7
None NON-PROTEIN TARGET Ratio CC50/EC50 50.0 None 10.1016/j.bmc.2016.05.010
None NON-PROTEIN TARGET Ratio CC50/EC50 11688.0 None 10.1016/j.bmc.2016.05.010
None NON-PROTEIN TARGET RT activity 17.0 % 10.1021/jm00042a005
None NON-PROTEIN TARGET Selectivity index 2000.0 None 10.1021/jm00060a013
None NON-PROTEIN TARGET Selectivity Index 6200.0 None 10.1021/jm200990c
None NON-PROTEIN TARGET TCID50 10.0 ug ml-1 10.1021/jm00170a017
None No relevant target Activity 66.54 uM 10.1021/jm5015296
None No relevant target LogD 0.05 None 10.1021/jm0000564
None No relevant target LogP -0.88 None 10.1021/jm001033s
None No relevant target LogP -0.88 None 10.1021/jm980358u
None No relevant target LogP 0.003 None 10.1021/jm000996o
None No relevant target LogP 0.025 None 10.1021/jm981096z
None No relevant target LogP 0.025 None 10.1021/jm981097r
None No relevant target LogP 0.05 None 10.1021/jm00109a018
None No relevant target LogP 0.052 None 10.1021/jm00007a015
None No relevant target LogP 0.88 None 10.1021/jm010863i
None No relevant target LogP 2.86 None 10.1021/jm00023a004
None No relevant target LogPapp 0.06 None 10.1021/jm021016y
None No relevant target P 1.29 None 10.1021/jm00047a013
None No relevant target P 1.29 None 10.1021/jm00051a006
None No relevant target P 1.68 None 10.1021/jm00163a043
None No relevant target Partition coefficient 1.12 None 10.1021/jm00109a012
None No relevant target Partition coefficient 1.3 None 10.1021/jm9408326
None No relevant target PC 1.2 None 10.1021/jm00167a034
None No relevant target pKa nan None 10.1021/jm0000564
None No relevant target pKa nan None 10.1021/jm030408h
None No relevant target solubility nan None 10.1016/j.ejmech.2016.05.054
None No relevant target Solubility 1240.0 ug.mL-1 10.1021/jm00023a004
None No relevant target Solubility 29300.0 ug.mL-1 10.1016/j.bmc.2008.06.024
None Nucleic Acid IC50 100000.0 nM 10.1021/jm00115a022
None Nucleic Acid Rblood_plasma 0.77 None 10.1124/dmd.110.037457
None Nucleic Acid Rblood_plasma 0.88 None 10.1124/dmd.110.037457
None Nucleic Acid Rblood_plasma 1.11 None 10.1124/dmd.110.037457
None Nucleic Acid Selectivity index 400.0 None 10.1021/jm00033a018
None PBL CD50 13.0 uM 10.1021/jm00062a006
None PBL EC50 29.0 nM 10.1021/jm00045a008
None PBL ID50 0.0003 ug ml-1 10.1021/jm00170a017
None PBL TCID50 3.0 ug ml-1 10.1021/jm00170a017
None Phospholipidosis Phospholipidosis nan None 10.1021/ci6004542
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None T-cell ID50 0.033 ug ml-1 10.1021/jm00170a017
None T-cell TCID50 100.0 ug ml-1 10.1021/jm00170a017
None Unchecked Ac50 2.512 uM None
None Unchecked Ac50 3.548 uM None
None Unchecked Ac50 4.467 uM None
None Unchecked Ac50 39.81 uM None
None Unchecked AC50 2511.9 nM None
None Unchecked AC50 3548.1 nM None
None Unchecked AC50 4466.8 nM None
None Unchecked AC50 39810.7 nM None
None Unchecked AC50 39820.0 nM None
None Unchecked Activity 0.015 % 10.1021/jm900275m
None Unchecked Activity 6.43 U/mg 10.1128/aac.01078-06
None Unchecked Activity 6.61 U/mg 10.1128/aac.01078-06
None Unchecked Activity 100.0 % 10.1016/j.bmc.2019.07.047
None Unchecked Activity nan None 10.1016/j.bmc.2021.116239
None Unchecked Activity nan None 10.1128/aac.01078-06
None Unchecked Activity nan None 10.1128/aac.01505-07
None Unchecked CC50 1000.0 nM 10.1021/acs.jmedchem.6b00659
None Unchecked CC50 13120.0 nM 10.1016/j.ejmech.2018.07.067
None Unchecked CC50 13880.0 nM 10.1016/j.ejmech.2019.111699
None Unchecked CC50 50000.0 nM 10.1016/j.bmc.2020.115488
None Unchecked CC50 100000.0 nM 10.1016/j.bmc.2019.07.047
None Unchecked CC50 100000.0 nM 10.1016/j.bmc.2020.115488
None Unchecked CC50 100000.0 nM 10.1016/j.bmcl.2019.05.016
None Unchecked CC50 126000.0 nM 10.1016/j.ejmech.2020.112255
None Unchecked CC50 374000.0 nM 10.1016/j.bmcl.2017.03.031
None Unchecked CC50 nan None 10.1016/j.bmc.2015.12.008
None Unchecked CD50 370.0 uM 10.1021/jm00062a006
None Unchecked EC50 4.0 nM 10.1021/acs.jmedchem.6b00659
None Unchecked EC50 11.0 nM 10.1016/j.bmc.2017.03.009
None Unchecked EC50 11.0 nM 10.1016/j.bmcl.2020.127287
None Unchecked EC50 16.0 nM 10.1016/j.bmcl.2020.127287
None Unchecked EC50 100.0 nM 10.1021/jm0400505
None Unchecked EC50 1197.0 nM 10.1016/j.bmcl.2020.127287
None Unchecked EC50 2700.0 nM 10.1016/j.bmcl.2019.05.016
None Unchecked EC50 34400.0 nM 10.1016/j.bmcl.2017.03.031
None Unchecked EC50 50000.0 nM None
None Unchecked EC50 129000.0 nM 10.1016/j.bmcl.2017.03.031
None Unchecked FI 0.3 None 10.1021/jm0300274
None Unchecked FI 0.3 None 10.1021/jm0303148
None Unchecked Hepatotoxicity (acute) 25.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 22.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 13.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 17.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 10.0 nM 10.1021/acs.jnatprod.2c00980
None Unchecked IC50 10.0 nM 10.1021/jm00086a013
None Unchecked IC50 15.0 ug.mL-1 10.1016/j.bmc.2006.10.033
None Unchecked IC50 18.0 nM 10.1021/acsmedchemlett.0c00414
None Unchecked IC50 50.0 nM 10.1016/j.ejmech.2020.112255
None Unchecked IC50 118.0 nM 10.1016/j.bmc.2020.115812
None Unchecked IC50 200.0 nM 10.1021/np50121a006
None Unchecked IC50 430.0 nM 10.1021/np50121a006
None Unchecked IC50 20000.0 nM 10.1021/np50121a006
None Unchecked IC50 20100.0 nM 10.1021/jm801176e
None Unchecked IC50 29320.0 nM None
None Unchecked IC50 39600.0 nM 10.1021/jm801176e
None Unchecked IC50 64590.0 nM None
None Unchecked IC50 150000.0 nM None
None Unchecked IC50 nan None 10.1016/j.bmc.2016.05.010
None Unchecked IC50 nan None 10.1016/j.bmcl.2007.06.008
None Unchecked IC50 nan None None
None Unchecked Inhibition nan % 10.1016/j.bmc.2017.07.001
None Unchecked Inhibition nan % 10.1016/j.bmcl.2007.06.008
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.5b01183
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.8b00511
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Inhibition nan % 10.1128/aac.00914-09
None Unchecked Ki nan None None
None Unchecked MIC 4.0 nM 10.1021/jm070285r
None Unchecked Potency 32629.4 nM None
None Unchecked Ratio 290.0 None 10.1021/jm00128a034
None Unchecked Ratio 666.0 None 10.1021/jm00394a034
None Unchecked Ratio 1667.0 None 10.1021/jm9600095
None Unchecked Ratio 2000.0 None 10.1016/S0960-894X(97)00340-5
None Unchecked Ratio 2000.0 None 10.1021/jm00047a011
None Unchecked Ratio 2600.0 None 10.1021/jm00108a041
None Unchecked Ratio 8000.0 None 10.1021/jm00047a011
None Unchecked Ratio 15170.0 None 10.1021/np50082a020
None Unchecked Ratio 17391.0 None 10.1021/jm00128a034
None Unchecked Ratio 28571.0 None 10.1021/jm00060a013
None Unchecked Ratio nan None 10.1016/S0960-894X(97)00022-X
None Unchecked Ratio nan None 10.1021/jm021108n
None Unchecked Ratio CC50/EC50 6.249 None 10.1016/j.bmcl.2020.127287
None Unchecked Ratio CC50/EC50 7.06 None 10.1016/j.ejmech.2015.11.039
None Unchecked Ratio CC50/EC50 21.0 None 10.1016/j.ejmech.2018.07.020
None Unchecked Ratio CC50/EC50 23.37 None 10.1016/j.bmcl.2020.127287
None Unchecked Ratio CC50/EC50 25.0 None 10.1021/acs.jnatprod.5b01012
None Unchecked Ratio CC50/EC50 116.0 None 10.1021/acs.jnatprod.5b00660
None Unchecked Ratio CC50/EC50 125.0 None 10.1016/j.bmc.2010.09.070
None Unchecked Ratio CC50/EC50 250.0 None 10.1021/acs.jmedchem.6b00659
None Unchecked Ratio CC50/EC50 267.0 None 10.1016/j.ejmech.2020.113051
None Unchecked Ratio CC50/EC50 293.0 None 10.1016/j.ejmech.2020.113051
None Unchecked Ratio CC50/EC50 311.0 None 10.1016/j.ejmech.2020.112811
None Unchecked Ratio CC50/EC50 397.0 None 10.1016/j.ejmech.2020.112811
None Unchecked Ratio CC50/EC50 448.0 None 10.1016/j.ejmech.2016.02.068
None Unchecked Ratio CC50/EC50 448.0 None 10.1021/acsmedchemlett.8b00054
None Unchecked Ratio CC50/EC50 471.39 None 10.1021/np070479+
None Unchecked Ratio CC50/EC50 515.0 None 10.1021/acs.jmedchem.8b01729
None Unchecked Ratio CC50/EC50 581.0 None 10.1016/j.ejmech.2018.03.059
None Unchecked Ratio CC50/EC50 625.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 645.0 None 10.1016/j.bmcl.2020.127287
None Unchecked Ratio CC50/EC50 645.0 None 10.1016/j.ejmech.2019.111619
None Unchecked Ratio CC50/EC50 658.0 None 10.1016/j.bmc.2018.03.003
None Unchecked Ratio CC50/EC50 662.0 None 10.1016/j.bmc.2017.03.009
None Unchecked Ratio CC50/EC50 664.0 None 10.1021/acsmedchemlett.7b00361
None Unchecked Ratio CC50/EC50 675.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 704.0 None 10.1016/j.ejmech.2018.03.059
None Unchecked Ratio CC50/EC50 704.0 None 10.1021/acs.jmedchem.8b01729
None Unchecked Ratio CC50/EC50 714.0 None 10.1016/j.ejmech.2019.111619
None Unchecked Ratio CC50/EC50 748.0 None 10.1021/acs.jmedchem.5b01183
None Unchecked Ratio CC50/EC50 901.0 None 10.1016/j.ejmech.2018.03.059
None Unchecked Ratio CC50/EC50 925.0 None 10.1016/j.ejmech.2016.02.068
None Unchecked Ratio CC50/EC50 935.0 None 10.1021/acs.jmedchem.5b01183
None Unchecked Ratio CC50/EC50 971.0 None 10.1016/j.bmcl.2017.03.009
None Unchecked Ratio CC50/EC50 971.0 None 10.1016/j.ejmech.2018.01.016
None Unchecked Ratio CC50/EC50 1000.0 None 10.1016/j.ejmech.2012.04.038
None Unchecked Ratio CC50/EC50 1004.0 None 10.1016/j.ejmech.2016.02.068
None Unchecked Ratio CC50/EC50 1004.0 None 10.1021/acsmedchemlett.8b00054
None Unchecked Ratio CC50/EC50 1026.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 1026.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 1053.0 None 10.1016/j.ejmech.2015.11.039
None Unchecked Ratio CC50/EC50 1053.0 None 10.1016/j.ejmech.2017.02.047
None Unchecked Ratio CC50/EC50 1053.0 None 10.1016/j.ejmech.2018.03.059
None Unchecked Ratio CC50/EC50 1058.0 None 10.1016/j.ejmech.2018.03.059
None Unchecked Ratio CC50/EC50 1120.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 1120.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 1180.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 1180.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 1288.0 None 10.1016/j.ejmech.2017.07.012
None Unchecked Ratio CC50/EC50 1340.0 None 10.1016/j.bmc.2008.11.056
None Unchecked Ratio CC50/EC50 1429.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 1429.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 1444.0 None 10.1016/j.ejmech.2018.03.059
None Unchecked Ratio CC50/EC50 1544.0 None 10.1016/j.ejmech.2018.03.059
None Unchecked Ratio CC50/EC50 1563.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 1563.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 1994.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 1994.0 None 10.1021/acs.jmedchem.7b00332
None Unchecked Ratio CC50/EC50 2399.0 None 10.1021/jm300477h
None Unchecked Ratio CC50/EC50 2475.0 None 10.1016/j.bmc.2008.11.056
None Unchecked Ratio CC50/EC50 2520.0 None 10.1016/j.bmc.2009.06.037
None Unchecked Ratio CC50/EC50 2520.0 None 10.1016/j.bmcl.2012.06.020
None Unchecked Ratio CC50/EC50 2769.0 None 10.1016/j.bmc.2013.06.061
None Unchecked Ratio CC50/EC50 3198.0 None 10.1016/j.ejmech.2015.01.042
None Unchecked Ratio CC50/EC50 3516.0 None 10.1021/acs.jnatprod.5b00073
None Unchecked Ratio CC50/EC50 3516.0 None 10.1021/acs.jnatprod.5b00116
None Unchecked Ratio CC50/EC50 4176.0 None 10.1021/acs.jnatprod.5b00073
None Unchecked Ratio CC50/EC50 4176.0 None 10.1021/acs.jnatprod.5b00116
None Unchecked Ratio CC50/EC50 4397.0 None 10.1016/j.bmc.2012.04.030
None Unchecked Ratio CC50/EC50 5000.0 None 10.1016/j.bmc.2009.05.049
None Unchecked Ratio CC50/EC50 5959.0 None 10.1016/j.ejmech.2014.02.047
None Unchecked Ratio CC50/EC50 6000.0 None 10.1016/j.bmc.2009.02.033
None Unchecked Ratio CC50/EC50 6192.0 None 10.1007/s00044-009-9220-x
None Unchecked Ratio CC50/EC50 6192.0 None 10.1016/j.bmc.2009.07.028
None Unchecked Ratio CC50/EC50 6192.0 None 10.1016/j.bmc.2011.05.024
None Unchecked Ratio CC50/EC50 6192.0 None 10.1016/j.bmcl.2008.09.055
None Unchecked Ratio CC50/EC50 6192.0 None 10.1016/j.ejmech.2009.06.037
None Unchecked Ratio CC50/EC50 6359.0 None 10.1016/j.bmc.2011.10.002
None Unchecked Ratio CC50/EC50 6359.0 None 10.1016/j.ejmech.2012.04.004
None Unchecked Ratio CC50/EC50 7716.0 None 10.1016/j.ejmech.2014.02.047
None Unchecked Ratio CC50/EC50 8269.0 None 10.1016/j.ejmech.2014.04.027
None Unchecked Ratio CC50/EC50 8269.0 None 10.1016/j.ejmech.2020.112696
None Unchecked Ratio CC50/EC50 8269.0 None 10.1021/acs.jmedchem.6b01906
None Unchecked Ratio CC50/EC50 8295.0 None 10.1016/j.bmc.2012.04.030
None Unchecked Ratio CC50/EC50 8295.0 None 10.1016/j.bmc.2012.07.026
None Unchecked Ratio CC50/EC50 8295.0 None 10.1016/j.bmcl.2012.09.062
None Unchecked Ratio CC50/EC50 9149.0 None 10.1016/j.ejmech.2015.01.042
None Unchecked Ratio CC50/EC50 9149.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 11587.0 None 10.1016/j.ejmech.2011.08.011
None Unchecked Ratio CC50/EC50 11587.0 None 10.1016/j.ejmech.2016.05.017
None Unchecked Ratio CC50/EC50 11904.0 None 10.1128/aac.01064-10
None Unchecked Ratio CC50/EC50 12034.0 None 10.1016/j.ejmech.2012.10.036
None Unchecked Ratio CC50/EC50 12221.0 None 10.1016/j.bmc.2012.09.058
None Unchecked Ratio CC50/EC50 12221.0 None 10.1016/j.ejmech.2012.02.019
None Unchecked Ratio CC50/EC50 12473.0 None 10.1016/j.ejmech.2014.02.047
None Unchecked Ratio CC50/EC50 12500.0 None 10.1016/j.bmcl.2015.01.058
None Unchecked Ratio CC50/EC50 12594.0 None 10.1016/j.bmc.2013.10.033
None Unchecked Ratio CC50/EC50 13066.0 None 10.1016/j.bmc.2013.10.033
None Unchecked Ratio CC50/EC50 13144.0 None 10.1016/j.bmc.2014.11.032
None Unchecked Ratio CC50/EC50 13144.0 None 10.1016/j.ejmech.2014.09.054
None Unchecked Ratio CC50/EC50 13144.0 None 10.1021/acs.jmedchem.6b00738
None Unchecked Ratio CC50/EC50 13213.0 None 10.1016/j.bmc.2016.04.010
None Unchecked Ratio CC50/EC50 13405.0 None 10.1016/j.ejmech.2016.05.054
None Unchecked Ratio CC50/EC50 13799.0 None 10.1016/j.bmc.2011.07.023
None Unchecked Ratio CC50/EC50 14445.0 None 10.1016/j.ejmech.2013.04.052
None Unchecked Ratio CC50/EC50 14445.0 None 10.1039/C3MD00247K
None Unchecked Ratio CC50/EC50 14970.0 None 10.1016/j.ejmech.2016.05.054
None Unchecked Ratio CC50/EC50 15592.0 None 10.1016/j.bmc.2008.01.039
None Unchecked Ratio CC50/EC50 15783.0 None 10.1016/j.bmc.2013.08.040
None Unchecked Ratio CC50/EC50 16785.0 None 10.1016/j.bmc.2015.03.037
None Unchecked Ratio CC50/EC50 17045.0 None 10.1016/j.bmc.2014.03.020
None Unchecked Ratio CC50/EC50 17990.0 None 10.1016/j.bmc.2008.01.039
None Unchecked Ratio CC50/EC50 26731.0 None 10.1016/j.ejmech.2016.05.017
None Unchecked Ratio CC50/EC50 28348.0 None 10.1016/j.ejmech.2011.08.011
None Unchecked Ratio CC50/EC50 29564.0 None 10.1016/j.bmcl.2012.09.062
None Unchecked Ratio CC50/EC50 36019.0 None 10.1021/jm1002952
None Unchecked Ratio CC50/EC50 50000.0 None 10.1021/np0704396
None Unchecked Ratio CC50/EC50 50587.0 None 10.1016/j.bmc.2007.10.013
None Unchecked Ratio CC50/EC50 56907.0 None 10.1016/j.bmc.2012.09.058
None Unchecked Ratio CC50/EC50 56907.0 None 10.1016/j.bmcl.2012.09.062
None Unchecked Ratio CC50/EC50 60606.1 None 10.1021/np060047j
None Unchecked Ratio CC50/EC50 68091.0 None 10.1016/j.bmcl.2008.02.040
None Unchecked Ratio CC50/EC50 100000.0 None 10.1021/jm2001103
None Unchecked Ratio CC50/EC50 133354.1 None 10.1016/j.bmc.2011.06.007
None Unchecked Ratio CC50/EC50 390406.06 None 10.1021/np0603166
None Unchecked Ratio CC50/EC50 422068.8 None 10.1016/j.bmc.2011.06.007
None Unchecked Ratio CC50/EC50 422068.8 None 10.1016/j.bmc.2011.07.003
None Unchecked Ratio CC50/EC50 500000.0 None 10.1021/np900123z
None Unchecked Ratio CC50/EC50 528975.0 None 10.1016/j.bmc.2011.05.060
None Unchecked Ratio CC50/EC50 1000000.0 None 10.1021/np0605236
None Unchecked Ratio CC50/EC50 nan None 10.1021/acs.jnatprod.5b00073
None Unchecked Ratio CC50/IC50 0.75 None 10.1016/j.bmc.2007.02.031
None Unchecked Ratio CC50/IC50 0.75 None 10.1016/j.bmc.2007.05.055
None Unchecked Ratio CC50/IC50 0.75 None 10.1016/j.ejmech.2007.04.001
None Unchecked Ratio CC50/IC50 0.75 None 10.1016/j.ejmech.2007.10.014
None Unchecked Ratio CC50/IC50 1.57 None 10.1016/j.bmc.2012.03.047
None Unchecked Ratio CC50/IC50 2.5 None 10.1016/j.bmc.2007.02.031
None Unchecked Ratio CC50/IC50 2.5 None 10.1016/j.bmc.2007.05.055
None Unchecked Ratio CC50/IC50 2.5 None 10.1016/j.ejmech.2007.04.001
None Unchecked Ratio CC50/IC50 2.5 None 10.1016/j.ejmech.2007.10.014
None Unchecked Ratio CC50/IC50 3.01 None 10.1016/j.bmc.2007.05.055
None Unchecked Ratio CC50/IC50 10.03 None 10.1016/j.bmc.2007.05.055
None Unchecked Ratio CC50/IC50 20.0 None 10.1021/acs.jnatprod.9b00088
None Unchecked Ratio CC50/IC50 267.1 None 10.1021/acs.jnatprod.8b00211
None Unchecked Ratio CC50/IC50 750.0 None 10.1021/acs.jnatprod.9b00993
None Unchecked Ratio CC50/IC50 2500.0 None 10.1016/j.bmc.2012.06.038
None Unchecked Ratio CC50/IC50 3516.0 None 10.1021/np500271u
None Unchecked Ratio CC50/IC50 4176.0 None 10.1021/np500271u
None Unchecked Ratio CC50/IC50 11363.0 None 10.1016/j.bmc.2016.08.029
None Unchecked Ratio CC50/IC50 11587.0 None 10.1007/s00044-013-0567-7
None Unchecked Ratio CC50/IC50 14124.0 None 10.1016/j.bmc.2014.02.030
None Unchecked Ratio CC50/IC50 14124.0 None 10.1016/j.ejmech.2014.05.059
None Unchecked Ratio CC50/IC50 26596.0 None 10.1016/j.bmc.2016.08.029
None Unchecked Ratio CC50/IC50 26731.0 None 10.1007/s00044-013-0567-7
None Unchecked Ratio CC50/IC50 444140.0 None 10.1016/j.bmcl.2010.12.003
None Unchecked Ratio CC50/IC50 nan None 10.1016/j.bmc.2012.06.038
None Unchecked Ratio EC50 0.3 None 10.1016/j.ejmech.2020.112811
None Unchecked Ratio EC50 0.4 None 10.1016/j.ejmech.2022.114512
None Unchecked Ratio EC50 0.4 None 10.1128/aac.00210-08
None Unchecked Ratio EC50 0.5 None 10.1016/j.ejmech.2020.112811
None Unchecked Ratio EC50 0.5 None 10.1016/j.ejmech.2022.114512
None Unchecked Ratio EC50 0.9 None 10.1016/j.ejmech.2020.112811
None Unchecked Ratio EC50 1.0 None 10.1016/j.ejmech.2020.112811
None Unchecked Ratio EC50 1.0 None 10.1016/j.ejmech.2021.113868
None Unchecked Ratio EC50 1.0 None 10.1016/j.ejmech.2022.114512
None Unchecked Ratio EC50 1.4 None 10.1016/j.ejmech.2020.112811
None Unchecked Ratio EC50 2.0 None 10.1016/j.ejmech.2021.113868
None Unchecked Ratio EC50 11.0 None 10.1016/j.ejmech.2021.113868
None Unchecked Ratio EC50 108.8 None 10.1016/j.bmcl.2020.127287
None Unchecked Ratio IC50 1.11 None 10.1016/j.bmcl.2019.08.003
None Unchecked Ratio IC50 1.21 None 10.1016/j.bmcl.2019.08.003
None Unchecked Ratio IC50 1.22 None 10.1016/j.bmcl.2019.08.003
None Unchecked Ratio IC50 1.34 None 10.1016/j.bmcl.2019.08.003
None Unchecked Ratio IC50 1.34 None 10.1021/acs.jmedchem.6b00764
None Unchecked Ratio IC50 1.48 None 10.1016/j.bmcl.2019.08.003
None Unchecked Ratio IC50 1.48 None 10.1021/acs.jmedchem.6b00764
None Unchecked Ratio IC50 1.88 None 10.1021/acs.jmedchem.6b00764
None Unchecked RT activity 19.2 % 10.1021/jm00042a005
None Unchecked Selectivity 62500.0 None 10.1016/0960-894X(96)00446-5
None Unchecked Selectivity index 1.2 SI 10.1021/jm00170a015
None Unchecked Selectivity index 50.0 None 10.1021/jm00086a013
None Unchecked Selectivity index 160.0 None 10.1021/jm00081a015
None Unchecked Selectivity index 300.0 None 10.1021/jm00081a015
None Unchecked Selectivity index 350.0 None 10.1021/jm00086a013
None Unchecked Selectivity index 500.0 None 10.1021/jm00020a015
None Unchecked Selectivity index 526.0 None 10.1021/jm050257d
None Unchecked Selectivity index 800.0 None 10.1021/jm00012a002
None Unchecked Selectivity index 1300.0 None 10.1021/jm00080a020
None Unchecked Selectivity index 1467.0 None 10.1021/jm00086a013
None Unchecked Selectivity index 1575.0 None 10.1021/jm00164a059
None Unchecked Selectivity index 1886.0 None 10.1021/jm050257d
None Unchecked Selectivity index 2000.0 None 10.1021/jm00020a015
None Unchecked Selectivity index 3000.0 None 10.1021/jm960500w
None Unchecked Selectivity index 3333.0 None 10.1021/jm00059a006
None Unchecked Selectivity index 4300.0 None 10.1021/jm00020a007
None Unchecked Selectivity index 8000.0 None 10.1016/s0960-894x(98)00384-9
None Unchecked Selectivity index 16556.0 None 10.1021/jm9607921
None Unchecked Selectivity index 17300.0 None 10.1021/jm00020a007
None Unchecked Selectivity index 20000.0 None 10.1016/0960-894X(96)00433-7
None Unchecked Selectivity index 27667.0 None 10.1021/jm00012a002
None Unchecked Selectivity index 82500.0 None 10.1021/jm00086a013
None Unchecked Selectivity index 100000.0 None 10.1021/jm960500w
None Unchecked Selectivity index 166666.0 None 10.1021/jm00047a013
None Unchecked Selectivity Index 1.0 None 10.1128/aac.01241-07
None Unchecked Selectivity Index 10.0 None 10.1021/np9700275
None Unchecked Selectivity Index 100.0 None 10.1016/j.ejmech.2019.111864
None Unchecked Selectivity Index 9149.0 None 10.1016/j.ejmech.2015.02.022
None Unchecked Selectivity Index 13144.0 None 10.1016/j.ejmech.2015.02.022
None Unchecked Selectivity Index 17990.0 None 10.1016/j.bmc.2010.06.067
None Unchecked Selectivity Index 22727.0 None 10.1016/j.ejmech.2011.02.014
None Unchecked Selectivity Index 460505.88 None 10.1016/j.ejmech.2019.111566
None Unchecked Selectivity Index nan None 10.1016/j.bmcl.2010.07.106
None Unchecked Selectivity ratio 20.6 None 10.1021/acsmedchemlett.0c00414
None Unchecked Selectivity ratio 8833.0 None 10.1021/jm00170a016
None Unchecked Selectivity ratio 11778.0 None 10.1021/jm00170a016
None Unchecked Selectivity ratio 16000.0 None 10.1021/jm00170a016
None Unchecked Selectivity ratio 21333.0 None 10.1021/jm00170a016
None Unchecked SI 1.5 None 10.1016/s0960-894x(01)00323-7
None Unchecked SI 3.5 None 10.1021/jm010863i
None Unchecked SI 6.0 None 10.1016/0960-894X(96)00334-4
None Unchecked SI 250.0 None 10.1021/jm0010365
None Unchecked SI 268.0 None 10.1021/jm010863i
None Unchecked SI 526.0 None 10.1021/jm0010365
None Unchecked SI 526.0 None 10.1021/jm950702c
None Unchecked SI 800.0 None 10.1016/0960-894X(96)00355-1
None Unchecked SI 1000.0 None 10.1021/jm001033s
None Unchecked SI 1067.0 None 10.1021/jm001033s
None Unchecked SI 1250.0 None 10.1021/jm00132a002
None Unchecked SI 1500.0 None 10.1021/jm00001a001
None Unchecked SI 1600.0 None 10.1021/jm00171a023
None Unchecked SI 2750.0 None 10.1021/jm00001a001
None Unchecked SI 2857.0 None 10.1021/jm00001a001
None Unchecked SI 4000.0 None 10.1021/jm001033s
None Unchecked SI 12900.0 None 10.1021/jm00105a064
None Unchecked SI 14000.0 None 10.1021/jm981096z
None Unchecked SI 16666.0 None 10.1021/jm950777g
None Unchecked SI 17000.0 None 10.1021/jm00105a064
None Unchecked SI 22000.0 None 10.1021/jm00001a001
None Unchecked SI 30000.0 None 10.1021/jm9507338
None Unchecked SI 35000.0 None 10.1016/s0960-894x(02)00041-0
None Unchecked SI 50000.0 None 10.1021/jm00001a001
None Unchecked SI 50587.0 None 10.1021/jm9802012
None Unchecked SI 83000.0 None 10.1021/jm9507338
None Unchecked SI nan None 10.1016/s0960-894x(01)00323-7
None Unchecked TC50 1.0 uM 10.1016/j.bmc.2017.03.061
None Unchecked TI 11200.0 None 10.1016/s0960-894x(03)00201-4

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT015093 Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](COP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O None
AKRT015094 Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O.O=C(O)[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO[C@@H]3O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]3O)O2)c(=O)[nH]c1=O enzymemap_34669
AKRT015095 Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](COP(=O)(O)O)O2)c(=O)[nH]c1=O enzymemap_43495
AKRT015097 Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](COP(=O)(O)O)O2)c(=O)[nH]c1=O>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O MNXR133709