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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK322765

Synonym: None

IUPAC Name: [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

Structure

SMILES: CC(=O)OC1=CC=CC=C1C(O)=NC1=NC=C([N+](=O)[O-])S1

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InChI: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

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InChIKey: YQNQNVDNTFHQSW-UHFFFAOYSA-N

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Reference

PubChem CID: 41684

CAS: 55981-09-4

NPASS: NPC478861

Properties Information

Molecule Weight: 307.28700000000003

TPSA？: 114.92000000000002

MolLogP？: 2.6129

Number of H-Donors: 1

Number of H-Acceptors: 7

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 9.65 % 10.6019/CHEMBL4513149
Acinetobacter baumannii Acinetobacter baumannii MIC 10000.0 nM 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii MIC 20000.0 nM 10.6019/CHEMBL4513161
Actinomyces viscosus Actinomyces viscosus MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Actinomyces viscosus Actinomyces viscosus MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Actinomyces viscosus Actinomyces viscosus MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus prevotii Anaerococcus prevotii MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Anaerococcus prevotii Anaerococcus prevotii MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Anaerococcus prevotii Anaerococcus prevotii MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus tetradius Anaerococcus tetradius MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Anaerococcus tetradius Anaerococcus tetradius MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Anaerococcus tetradius Anaerococcus tetradius MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Bacillus anthracis Anthrax lethal factor Potency 1258.9 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 50118.7 nM None
Bacteroides caccae Bacteroides caccae MIC 0.5 ug.mL-1 10.1128/aac.00441-08
Bacteroides caccae Bacteroides caccae MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides caccae Bacteroides caccae MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides fragilis Bacteroides fragilis MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides fragilis Bacteroides fragilis MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides fragilis Bacteroides fragilis MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides ovatus Bacteroides ovatus MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides ovatus Bacteroides ovatus MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides ovatus Bacteroides ovatus MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides stercoris Bacteroides stercoris MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides stercoris Bacteroides stercoris MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides stercoris Bacteroides stercoris MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides uniformis Bacteroides uniformis MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides uniformis Bacteroides uniformis MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides uniformis Bacteroides uniformis MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium bifidum Bifidobacterium bifidum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium bifidum Bifidobacterium bifidum MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium bifidum Bifidobacterium bifidum MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium breve Bifidobacterium breve MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium breve Bifidobacterium breve MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium breve Bifidobacterium breve MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium longum Bifidobacterium longum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium longum Bifidobacterium longum MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium longum Bifidobacterium longum MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Campylobacter jejuni Campylobacter jejuni MIC 800.0 nM 10.1016/j.bmcl.2010.04.126
Campylobacter jejuni subsp. jejuni Pyruvate-flavodoxin oxidoreductase Activity 20.0 nmol/mg/min 10.1128/aac.01159-06
Campylobacter jejuni subsp. jejuni Pyruvate-flavodoxin oxidoreductase Ki 10500.0 nM 10.1128/aac.01159-06
Candida albicans Candida albicans Inhibition 26.69 % 10.6019/CHEMBL4513149
Candida albicans Candida albicans MIC 10000.0 nM 10.6019/CHEMBL4513141
Candida albicans Candida albicans MIC 20000.0 nM 10.6019/CHEMBL4513161
Chikungunya virus Chikungunya virus EC50 1960.0 nM 10.1016/j.bmc.2017.06.049
Chikungunya virus Chikungunya virus EC50 2960.0 nM 10.1016/j.bmc.2017.06.049
Chikungunya virus Chikungunya virus EC50 3010.0 nM 10.1016/j.bmc.2017.06.049
Chikungunya virus Chikungunya virus EC50 4950.0 nM 10.1016/j.bmc.2017.06.049
Chlorocebus sabaeus Vero CC50 833000.0 nM 10.1016/j.bmc.2014.01.029
Chlorocebus sabaeus Vero CC50 833000.0 nM 10.1016/j.bmc.2015.02.059
Chlorocebus sabaeus Vero CC50 833000.0 nM 10.1016/j.bmcl.2011.02.100
Chlorocebus sabaeus Vero CC50 833000.0 nM 10.1016/j.bmcl.2017.05.071
Chlorocebus sabaeus Vero IC50 10740.0 nM 10.1016/j.bmc.2013.05.036
Chlorocebus sabaeus Vero C1008 AUC cytotoxicity 238.4 None 10.1038/s41586-020-2286-9
Chlorocebus sabaeus Vero C1008 CC50 35500.0 nM 10.1021/acs.jmedchem.0c00626
Chlorocebus sabaeus Vero C1008 pCC50 4.7 None 10.1038/s41586-020-2286-9
Clostridioides difficile Clostridioides difficile MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridioides difficile Clostridioides difficile MIC 39100.0 nM 10.1016/j.bmcl.2010.04.126
Clostridioides difficile Clostridioides difficile MIC50 0.06 ug.mL-1 10.1128/aac.01623-06
Clostridioides difficile Clostridioides difficile MIC50 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridioides difficile Clostridioides difficile MIC90 0.125 ug.mL-1 10.1128/aac.01623-06
Clostridioides difficile Clostridioides difficile MIC90 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium acetobutylicum Clostridium acetobutylicum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium acetobutylicum Clostridium acetobutylicum MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium acetobutylicum Clostridium acetobutylicum MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium beijerinckii Clostridium beijerinckii MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium beijerinckii Clostridium beijerinckii MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium beijerinckii Clostridium beijerinckii MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium butyricum Clostridium butyricum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium butyricum Clostridium butyricum MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium butyricum Clostridium butyricum MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium cadaveris Clostridium cadaveris MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium cadaveris Clostridium cadaveris MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium cadaveris Clostridium cadaveris MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
[Clostridium] innocuum [Clostridium] innocuum MIC 0.5 ug.mL-1 10.1128/aac.00441-08
[Clostridium] innocuum [Clostridium] innocuum MIC50 1.0 ug.mL-1 10.1128/aac.00441-08
[Clostridium] innocuum [Clostridium] innocuum MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium paraputrificum Clostridium paraputrificum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium paraputrificum Clostridium paraputrificum MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium paraputrificum Clostridium paraputrificum MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium perfringens Clostridium perfringens MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium perfringens Clostridium perfringens MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Clostridium perfringens Clostridium perfringens MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium perfringens (strain SM101 / Type A) Pyruvate-flavodoxin oxidoreductase Activity 56.5 nmol/mg/min 10.1128/aac.01159-06
Clostridium septicum Clostridium septicum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium septicum Clostridium septicum MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium septicum Clostridium septicum MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium sporogenes Clostridium sporogenes MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium sporogenes Clostridium sporogenes MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium sporogenes Clostridium sporogenes MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Clostridium tertium Clostridium tertium MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Clostridium tertium Clostridium tertium MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Clostridium tertium Clostridium tertium MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Collinsella aerofaciens Collinsella aerofaciens MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Collinsella aerofaciens Collinsella aerofaciens MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Collinsella aerofaciens Collinsella aerofaciens MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Cryptococcus neoformans Cryptococcus neoformans Inhibition 17.15 % 10.6019/CHEMBL4513149
Cryptococcus neoformans Cryptococcus neoformans MIC 10000.0 nM 10.6019/CHEMBL4513141
Cryptococcus neoformans Cryptococcus neoformans MIC 20000.0 nM 10.6019/CHEMBL4513161
Cryptosporidium Cryptosporidium MIC 10.0 ug.mL-1 10.1021/jm9010719
Cryptosporidium parvum Cryptosporidium parvum Activity 5.0 % 10.1128/aac.00207-08
Cryptosporidium parvum Cryptosporidium parvum Activity nan None 10.1021/acs.jmedchem.1c01136
Cryptosporidium parvum Cryptosporidium parvum Activity nan None 10.1128/aac.00207-08
Cryptosporidium parvum Cryptosporidium parvum EC50 2000.0 nM 10.1021/acs.jmedchem.1c01136
Cryptosporidium parvum Cryptosporidium parvum EC50 2300.0 nM 10.1021/acs.jnatprod.7b00850
Cryptosporidium parvum Cryptosporidium parvum EC50 2900.0 nM 10.1021/acs.jnatprod.7b00850
Cryptosporidium parvum Cryptosporidium parvum EC50 3700.0 nM 10.1016/j.bmc.2023.117295
Cryptosporidium parvum Cryptosporidium parvum IC50 1.2 ug.mL-1 10.1128/aac.00614-09
Cryptosporidium parvum Cryptosporidium parvum IC50 10.0 ug.mL-1 10.1128/aac.00614-09
Cryptosporidium parvum Cryptosporidium parvum IC50 3250.0 nM 10.1021/jm050973f
Cryptosporidium parvum Cryptosporidium parvum IC50 3800.0 nM 10.1128/aac.00207-08
Cutibacterium acnes Cutibacterium acnes MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Cutibacterium acnes Cutibacterium acnes MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Cutibacterium acnes Cutibacterium acnes MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Echinococcus multilocularis Echinococcus multilocularis Activity nan None 10.1128/aac.00378-07
Eggerthella lenta Eggerthella lenta MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Eggerthella lenta Eggerthella lenta MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Eggerthella lenta Eggerthella lenta MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Entamoeba histolytica Entamoeba histolytica IC50 504.0 nM 10.1016/j.bmcl.2011.02.100
Entamoeba histolytica Entamoeba histolytica IC50 3900.0 nM 10.1016/j.bmc.2013.05.036
Enterocloster clostridioformis Enterocloster clostridioformis MIC50 0.25 ug.mL-1 10.1128/aac.00441-08
Enterocloster clostridioformis Enterocloster clostridioformis MIC90 0.25 ug.mL-1 10.1128/aac.00441-08
Escherichia coli Escherichia coli Inhibition -2.79 % 10.6019/CHEMBL4513149
Escherichia coli Escherichia coli Inhibition 35.0 % 10.1128/aac.01159-06
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01159-06
Escherichia coli Escherichia coli MIC 10000.0 nM 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC 20000.0 nM 10.6019/CHEMBL4513161
Eubacterium limosum Eubacterium limosum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Eubacterium limosum Eubacterium limosum MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Eubacterium limosum Eubacterium limosum MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Finegoldia magna Finegoldia magna MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Finegoldia magna Finegoldia magna MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Finegoldia magna Finegoldia magna MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium mortiferum Fusobacterium mortiferum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Fusobacterium mortiferum Fusobacterium mortiferum MIC50 1.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium mortiferum Fusobacterium mortiferum MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium necrophorum Fusobacterium necrophorum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Fusobacterium necrophorum Fusobacterium necrophorum MIC50 1.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium necrophorum Fusobacterium necrophorum MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium nucleatum Fusobacterium nucleatum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Fusobacterium nucleatum Fusobacterium nucleatum MIC50 0.25 ug.mL-1 10.1128/aac.00441-08
Fusobacterium nucleatum Fusobacterium nucleatum MIC90 0.5 ug.mL-1 10.1128/aac.00441-08
Fusobacterium sp. Fusobacterium sp. MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Fusobacterium sp. Fusobacterium sp. MIC50 1.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium sp. Fusobacterium sp. MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium varium Fusobacterium varium MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Fusobacterium varium Fusobacterium varium MIC50 1.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium varium Fusobacterium varium MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Giardia Giardia IC50 2.5 ug.mL-1 10.1021/jm9010719
Giardia intestinalis Giardia intestinalis Activity nan None 10.1128/aac.01548-06
Giardia intestinalis Giardia intestinalis ED50 1.101 mg.kg-1 10.1016/j.bmcl.2017.05.071
Giardia intestinalis Giardia intestinalis ED50 3.583 umol.kg-1 10.1016/j.bmcl.2017.05.071
Giardia intestinalis Giardia intestinalis IC50 15.0 nM 10.1016/j.ejmech.2020.113110
Giardia intestinalis Giardia intestinalis IC50 17.0 nM 10.1016/j.ejmech.2020.113110
Giardia intestinalis Giardia intestinalis IC50 18.0 nM 10.1016/j.ejmech.2020.113110
Giardia intestinalis Giardia intestinalis IC50 21.0 nM 10.1016/j.ejmech.2020.113110
Giardia intestinalis Giardia intestinalis IC50 1214.0 nM 10.1016/j.bmc.2014.01.029
Giardia intestinalis Giardia intestinalis IC50 1214.0 nM 10.1016/j.bmc.2015.02.059
Giardia intestinalis Giardia intestinalis IC50 1214.0 nM 10.1016/j.bmcl.2011.02.100
Giardia intestinalis Giardia intestinalis IC50 1214.0 nM 10.1016/j.bmcl.2017.05.071
Giardia intestinalis Giardia intestinalis IC50 1230.27 nM 10.1016/j.bmc.2014.01.029
Giardia intestinalis Giardia intestinalis IC50 1230.27 nM 10.1016/j.bmc.2015.02.059
Giardia intestinalis Giardia intestinalis IC50 1973.0 nM 10.1016/j.ejmech.2020.113110
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 14091.9 nM None
Helicobacter pylori Helicobacter pylori MIC 13000.0 nM 10.1016/j.bmcl.2010.04.126
Hepacivirus hominis Hepatitis C virus EC50 130.0 nM 10.1128/aac.00078-08
Hepacivirus hominis Hepatitis C virus EC50 160.0 nM 10.1128/aac.00078-08
Hepacivirus hominis Hepatitis C virus EC50 210.0 nM 10.1021/jm201264t
Hepacivirus hominis Hepatitis C virus EC50 330.0 nM 10.1021/jm201264t
Hepacivirus hominis Hepatitis C virus EC50 1200.0 nM 10.1128/aac.00078-08
Hepacivirus hominis Hepatitis C virus EC50 1500.0 nM 10.1128/aac.00078-08
Hepacivirus hominis Hepatitis C virus EC90 0.93 uM 10.1021/jm201264t
Hepacivirus hominis Hepatitis C virus EC90 1.1 uM 10.1021/jm201264t
Hepacivirus hominis Hepatitis C virus EC90 1.2 uM 10.1128/aac.00078-08
Hepacivirus hominis Hepatitis C virus EC90 17.0 uM 10.1128/aac.00078-08
Hepacivirus hominis Hepatitis C virus EC90 26.0 uM 10.1128/aac.00078-08
Hepatitis B virus Hepatitis B virus EC50 120.0 nM 10.1016/j.ejmech.2014.01.046
Hepatitis B virus Hepatitis B virus EC50 120.0 nM 10.1021/jm200153p
Hepatitis B virus Hepatitis B virus EC50 120.0 nM 10.1039/C4MD00521J
Hepatitis B virus Hepatitis B virus EC50 590.0 nM 10.1021/jm200153p
Hepatitis B virus Hepatitis B virus EC90 0.83 uM 10.1021/jm200153p
Hepatitis B virus Hepatitis B virus EC90 2.1 uM 10.1021/jm200153p
Hepatitis B virus Hepatitis B virus IC50 120.0 nM 10.1021/acs.jmedchem.6b01442
Homo sapiens 786-0 GI50 26668.59 nM None
Homo sapiens A498 GI50 56234.13 nM None
Homo sapiens A549 Activity nan None 10.1021/acs.jmedchem.8b01044
Homo sapiens A549 GI50 21978.6 nM None
Homo sapiens A549 IC50 50000.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens Acetylcholinesterase AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens ACHN GI50 20417.38 nM None
Homo sapiens Adenosine A1 receptor AC50 7100.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 8799.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 5000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 9876.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Aldose reductase IC50 8220.0 nM 10.1021/jm500907a
Homo sapiens Alpha-1a adrenergic receptor AC50 8600.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 18999.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 8000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor Potency 15848.9 nM None
Homo sapiens Androgen Receptor Potency 35481.3 nM None
Homo sapiens Anoctamin-1 IC50 424.0 nM 10.1016/j.ejmech.2022.114413
Homo sapiens Aryl hydrocarbon receptor Potency 707.9 nM None
Homo sapiens ASPC1 Activity nan None 10.1021/acs.jmedchem.8b01044
Homo sapiens Beta-1 adrenergic receptor AC50 8799.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 7799.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile acid receptor FXR Potency 6309.6 nM None
Homo sapiens Bile acid receptor FXR Potency 7943.3 nM None
Homo sapiens Bile salt export pump AC50 44999.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B2 receptor AC50 4900.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 79432.8 nM None
Homo sapiens BT-549 GI50 14421.15 nM None
Homo sapiens Caco-2 Activity nan None 10.1021/acs.jmedchem.8b01044
Homo sapiens Caco-2 IC50 26800.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens Caco-2 IC50 221000.0 nM 10.1016/j.bmcl.2017.05.073
Homo sapiens Caco-2 Inhibition 80.0 % 10.1016/j.bmcl.2017.05.073
Homo sapiens Caco-2 Inhibition nan % 10.1016/j.bmcl.2017.05.073
Homo sapiens CAKI-1 GI50 26485.0 nM None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cellular tumor antigen p53 Potency 10000.0 nM None
Homo sapiens Cellular tumor antigen p53 Potency 12589.3 nM None
Homo sapiens Cholecystokinin A receptor AC50 6599.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens COLO 205 GI50 12705.74 nM None
Homo sapiens Cyclooxygenase-1 AC50 11.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 9526.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 3A4 Potency 7943.3 nM None
Homo sapiens Delta opioid receptor AC50 5000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens DNA polymerase kappa Potency 29934.9 nM None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 14000.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 25000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 7300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens DU-145 GI50 20137.24 nM None
Homo sapiens EKVX GI50 20989.4 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 12589.3 nM None
Homo sapiens Endothelin receptor ET-A AC50 12000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 1900.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha Potency 12589.3 nM None
Homo sapiens Ferrochelatase, mitochondrial Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 13335.9 nM None
Homo sapiens Ghrelin receptor AC50 15000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor Potency 2511.9 nM None
Homo sapiens HCC 2998 GI50 13001.7 nM None
Homo sapiens HCT-116 GI50 11168.63 nM None
Homo sapiens HCT-15 GI50 19860.95 nM None
Homo sapiens HCT-8 Activity nan None 10.1128/aac.00614-09
Homo sapiens HCT-8 EC50 25000.0 nM 10.1021/acs.jnatprod.7b00850
Homo sapiens HEK293 CC50 8585.0 nM 10.6019/CHEMBL4513161
Homo sapiens HEK293 CC50 10000.0 nM 10.6019/CHEMBL4513141
Homo sapiens HEK-293T Activity nan None 10.1016/j.bmcl.2012.10.060
Homo sapiens HEK-293T CC50 40000.0 nM 10.1021/acs.jnatprod.7b00850
Homo sapiens HEK-293T Inhibition -3.3 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HEK-293T Inhibition 24.4 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 0.02 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 0.04 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 0.06 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 2.34 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 4.49 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 5.32 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 6.6 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 7.48 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 8.27 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 9.59 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 11.4 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 15.12 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 21.84 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 22.76 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 28.45 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 61.96 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 69.88 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 70.64 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 77.33 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 84.07 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Activity 92.32 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa IC50 35000.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens HeLa Inhibition 19.4 % 10.1021/acsmedchemlett.0c00544
Homo sapiens HepG2 CC50 40000.0 nM 10.1021/acs.jnatprod.7b00850
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HET-1A Activity nan None 10.1021/acs.jmedchem.8b01044
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone acetyltransferase GCN5 Potency 35481.3 nM None
Homo sapiens Histone deacetylase 6 IC50 1011.0 nM 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 98.28 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 102.97 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 109.78 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 11220.2 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 39810.7 nM None
Homo sapiens HL-60 IC50 20100.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 30.0 % 10.1016/j.ejmech.2016.09.080
Homo sapiens HOP-62 GI50 22284.35 nM None
Homo sapiens HOP-92 GI50 3221.07 nM None
Homo sapiens Hs-578T GI50 9204.5 nM None
Homo sapiens HT-29 GI50 15488.17 nM None
Homo sapiens HT-29 IC50 50000.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens Huntingtin Potency 25118.9 nM None
Homo sapiens IGROV-1 GI50 16292.96 nM None
Homo sapiens K562 GI50 55718.57 nM None
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens KM12 GI50 21978.6 nM None
Homo sapiens LOX IMVI GI50 21827.3 nM None
Homo sapiens Lymphoblastoid cell Potency 12589.3 nM None
Homo sapiens Lymphoblastoid cell Potency 25118.9 nM None
Homo sapiens Lymphoblastoid cell Potency 31622.8 nM None
Homo sapiens Lymphoblastoid cell Potency 39810.7 nM None
Homo sapiens Lymphoblastoid cell Potency 50118.7 nM None
Homo sapiens M14 GI50 15885.47 nM None
Homo sapiens Malme-3M GI50 11142.95 nM None
Homo sapiens MAP kinase ERK2 Potency 39810.7 nM None
Homo sapiens MCF7 GI50 10185.91 nM None
Homo sapiens MDA-MB-231 GI50 21827.3 nM None
Homo sapiens MDA-MB-435 GI50 22750.97 nM None
Homo sapiens MDA-N GI50 27289.78 nM None
Homo sapiens Melanocortin receptor 3 AC50 14000.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 14125.4 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 28183.8 nM None
Homo sapiens microRNA 21 Potency 414.0 nM None
Homo sapiens Microtubule-associated protein tau Potency 11220.2 nM None
Homo sapiens MOLT-4 GI50 100000.0 nM None
Homo sapiens Monoamine oxidase A AC50 7500.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 12999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 4333.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 1400.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 12999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscleblind-like protein 1 Potency 8912.5 nM None
Homo sapiens NCI/ADR-RES GI50 10327.61 nM None
Homo sapiens NCI-H226 GI50 8830.8 nM None
Homo sapiens NCI-H23 GI50 9727.47 nM None
Homo sapiens NCI-H322M GI50 18706.82 nM None
Homo sapiens NCI-H460 GI50 17060.82 nM None
Homo sapiens NCI-H522 GI50 2857.59 nM None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 8799.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide S receptor Potency 3162.3 nM None
Homo sapiens Neuropeptide Y receptor type 1 AC50 17000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Niemann-Pick C1 protein Potency 501.2 nM None
Homo sapiens Norepinephrine transporter AC50 5100.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 18833.6 nM None
Homo sapiens Nuclear receptor ROR-gamma Potency 4216.3 nM None
Homo sapiens OVCAR-3 GI50 5714.79 nM None
Homo sapiens OVCAR-4 GI50 28707.81 nM None
Homo sapiens OVCAR-5 GI50 29853.83 nM None
Homo sapiens OVCAR-8 GI50 15667.51 nM None
Homo sapiens PC-3 Activity nan None 10.1021/acs.jmedchem.8b01044
Homo sapiens PC-3 GI50 9527.96 nM None
Homo sapiens PC-3 IC50 44700.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 14125.4 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 44668.4 nM None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Plasma PPB 95.0 % 10.1021/jm200153p
Homo sapiens Plasma T1/2 0.1 hr 10.1021/jm200153p
Homo sapiens Porphobilinogen deaminase Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Pregnane X receptor AC50 18999.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 8912.5 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pyruvate kinase isozymes M1/M2 Potency 14125.4 nM None
Homo sapiens Ras-related protein Rab-9A Potency 501.2 nM None
Homo sapiens Retinoid X receptor alpha Potency 8912.5 nM None
Homo sapiens RPMI-8226 GI50 10327.61 nM None
Homo sapiens RXF 393 GI50 4415.7 nM None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 15000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 17000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 450.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 3100.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 6300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens SF-268 GI50 14859.36 nM None
Homo sapiens SF-295 GI50 9908.32 nM None
Homo sapiens SF-539 GI50 24831.33 nM None
Homo sapiens Signal transducer and activator of transcription 3 Activity nan None 10.1021/acsmedchemlett.0c00544
Homo sapiens Signal transducer and activator of transcription 3 IC50 9800.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens Signal transducer and activator of transcription 3 IC50 9980.0 nM 10.1021/acsmedchemlett.0c00544
Homo sapiens Signal transducer and activator of transcription 3 Inhibition 54.6 % 10.1021/acsmedchemlett.0c00544
Homo sapiens Signal transducer and activator of transcription 3 Inhibition nan % 10.1021/acsmedchemlett.0c00544
Homo sapiens Signal transducer and activator of transcription 5A Inhibition nan % 10.1021/acsmedchemlett.0c00544
Homo sapiens SK-MEL-2 GI50 16330.52 nM None
Homo sapiens SK-MEL-28 GI50 11587.77 nM None
Homo sapiens SK-MEL-5 GI50 11939.88 nM None
Homo sapiens SK-OV-3 GI50 14655.48 nM None
Homo sapiens SN12C GI50 19815.27 nM None
Homo sapiens SNB-19 GI50 17864.88 nM None
Homo sapiens SNB-75 GI50 10162.49 nM None
Homo sapiens Survival motor neuron protein Potency 12589.3 nM None
Homo sapiens SW-620 GI50 33113.11 nM None
Homo sapiens T47D GI50 13708.82 nM None
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 5000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thyroid stimulating hormone receptor Potency 5011.9 nM None
Homo sapiens TK-10 GI50 16069.41 nM None
Homo sapiens Type-1 angiotensin II receptor AC50 5600.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition nan % 10.1021/acsmedchemlett.0c00544
Homo sapiens Tyrosine-protein kinase SRC Inhibition nan % 10.1021/acsmedchemlett.0c00544
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 9441.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 21136.0 nM None
Homo sapiens U-251 GI50 19408.86 nM None
Homo sapiens U2OS CC50 25000.0 nM 10.1016/j.bmc.2017.06.049
Homo sapiens UACC-257 GI50 17218.69 nM None
Homo sapiens UACC-62 GI50 4325.14 nM None
Homo sapiens UO-31 GI50 26001.6 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 17000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 14000.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 35481.3 nM None
Hoylesella loescheii Hoylesella loescheii MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Hoylesella loescheii Hoylesella loescheii MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Hoylesella loescheii Hoylesella loescheii MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 13.55 % 10.6019/CHEMBL4513149
Klebsiella pneumoniae Klebsiella pneumoniae MIC 10000.0 nM 10.6019/CHEMBL4513141
Klebsiella pneumoniae Klebsiella pneumoniae MIC 20000.0 nM 10.6019/CHEMBL4513161
Lacticaseibacillus rhamnosus Lacticaseibacillus rhamnosus MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Lacticaseibacillus rhamnosus Lacticaseibacillus rhamnosus MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Lacticaseibacillus rhamnosus Lacticaseibacillus rhamnosus MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Lactiplantibacillus plantarum Lactiplantibacillus plantarum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Lactiplantibacillus plantarum Lactiplantibacillus plantarum MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Lactiplantibacillus plantarum Lactiplantibacillus plantarum MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus acidophilus Lactobacillus acidophilus MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Lactobacillus acidophilus Lactobacillus acidophilus MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus acidophilus Lactobacillus acidophilus MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus jensenii Lactobacillus jensenii MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Lactobacillus jensenii Lactobacillus jensenii MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus jensenii Lactobacillus jensenii MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus sp. Lactobacillus sp. MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Lactobacillus sp. Lactobacillus sp. MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus sp. Lactobacillus sp. MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Leishmania amazonensis Leishmania amazonensis IC50 7230.0 nM 10.1016/j.bmc.2014.01.029
Leishmania amazonensis Leishmania amazonensis IC50 7230.0 nM 10.1016/j.bmcl.2017.05.071
Leishmania amazonensis Leishmania amazonensis Ratio IC50 2.0 None 10.1016/j.bmc.2014.01.029
Leishmania mexicana Leishmania mexicana IC50 6180.0 nM 10.1016/j.bmcl.2011.02.100
Leishmania mexicana Leishmania mexicana IC50 6180.0 nM 10.1016/j.bmcl.2017.05.071
Leishmania mexicana Pyruvate kinase Potency 12589.3 nM None
Limosilactobacillus fermentum Limosilactobacillus fermentum MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus fermentum Limosilactobacillus fermentum MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus fermentum Limosilactobacillus fermentum MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus reuteri Limosilactobacillus reuteri MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus reuteri Limosilactobacillus reuteri MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus reuteri Limosilactobacillus reuteri MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Meriones unguiculatus Meriones unguiculatus Activity 14.0 % 10.1021/jm050973f
Meriones unguiculatus Meriones unguiculatus Activity 55.0 % 10.1021/jm050973f
Mesocricetus auratus BHK-21 CC50 25000.0 nM 10.1016/j.bmc.2017.06.049
Mus musculus Nuclear receptor ROR-gamma Potency 2818.4 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 19952.6 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 35481.3 nM None
Mus musculus Peritoneal macrophage IC50 2000000.0 nM 10.1016/j.bmc.2020.115757
Mus musculus RAW264.7 IC50 1540000.0 nM 10.1016/j.bmc.2020.115757
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity 1.0 None 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity 2.0 None 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity 3.5 None 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity 5.0 None 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity 6.0 None 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1021/ml200157f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1021/ml200157f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1021/jm9010719
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 10000.0 nM 10.1016/j.bmc.2022.116938
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 33190.0 nM 10.1016/j.ejmech.2021.114066
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 52120.0 nM 10.1016/j.bmcl.2011.06.076
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 162710.0 nM 10.1016/j.bmcl.2012.10.060
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1016/j.bmcl.2011.06.076
Mycobacterium tuberculosis Trehalose-binding lipoprotein LpqY Kd 85400.0 nM 10.1039/d2md00104g
Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv Drug metabolism nan None 10.1021/ml200157f
Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv Drug uptake nan None 10.1021/ml200157f
Naegleria gruberi Naegleria gruberi Inhibition 62.7 % 10.6019/CHEMBL4513101
Paeniclostridium sordellii Paeniclostridium sordellii MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Paeniclostridium sordellii Paeniclostridium sordellii MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Paeniclostridium sordellii Paeniclostridium sordellii MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides distasonis Parabacteroides distasonis MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides distasonis Parabacteroides distasonis MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides distasonis Parabacteroides distasonis MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides merdae Parabacteroides merdae MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides merdae Parabacteroides merdae MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides merdae Parabacteroides merdae MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Paraclostridium bifermentans Paraclostridium bifermentans MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Paraclostridium bifermentans Paraclostridium bifermentans MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Paraclostridium bifermentans Paraclostridium bifermentans MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Parvimonas micra Parvimonas micra MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Parvimonas micra Parvimonas micra MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Parvimonas micra Parvimonas micra MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Photinus pyralis Luciferin 4-monooxygenase Potency 720.8 nM None
Photinus pyralis Luciferin 4-monooxygenase Potency 6745.6 nM None
Plasmodium berghei Plasmodium berghei IC50 3890.0 nM 10.1016/j.bmcl.2011.02.100
Plasmodium falciparum Plasmodium falciparum Potency 15101.4 nM None
Plasmodium falciparum Plasmodium falciparum Potency 19011.5 nM None
Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Porphyromonas somerae Porphyromonas somerae MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Porphyromonas somerae Porphyromonas somerae MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Porphyromonas somerae Porphyromonas somerae MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
Prevotella bivia Prevotella bivia MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Prevotella bivia Prevotella bivia MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Prevotella bivia Prevotella bivia MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella corporis Prevotella corporis MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Prevotella corporis Prevotella corporis MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Prevotella corporis Prevotella corporis MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella disiens Prevotella disiens MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Prevotella disiens Prevotella disiens MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Prevotella disiens Prevotella disiens MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella intermedia Prevotella intermedia MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Prevotella intermedia Prevotella intermedia MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Prevotella intermedia Prevotella intermedia MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella melaninogenica Prevotella melaninogenica MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Prevotella melaninogenica Prevotella melaninogenica MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
Prevotella melaninogenica Prevotella melaninogenica MIC90 8.0 ug.mL-1 10.1128/aac.00441-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 19.1 % 10.6019/CHEMBL4513149
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10000.0 nM 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20000.0 nM 10.6019/CHEMBL4513161
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 3.1 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Potency 44668.4 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 454.8 nM None
Rattus norvegicus Plasma Drug metabolism nan None 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus AUC 2040.0 ng.hr.mL-1 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus AUC 6500.0 ng.hr.mL-1 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus AUC 14100.0 ng.hr.mL-1 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus AUC 15950.0 ng.hr.mL-1 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Cmax 2414.66 nM 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Cmax 15034.66 nM 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Cmax 35959.52 nM 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Cmax 66712.23 nM 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus F 2.8 % 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus T1/2 0.2 hr 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Tmax 0.08333 hr 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Tmax 0.4 hr 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Tmax 0.7 hr 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Tmax 1.4 hr 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Rattus norvegicus Tmax 2.1 hr 10.1016/j.ejmech.2016.09.080
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Schaalia meyeri Schaalia meyeri MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Schaalia meyeri Schaalia meyeri MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
Schaalia meyeri Schaalia meyeri MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 11.0 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 100.65 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 AUC 202.3 None 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 EC50 2120.0 nM 10.1021/acs.jmedchem.0c00626
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.4584 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 2818.38 nM 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 82700.0 nM 10.1021/acs.jnatprod.2c00580
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.07 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.78 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 43.61 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.6122 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Inhibition 50.75 % 10.6019/CHEMBL4513149
Staphylococcus aureus Staphylococcus aureus MIC 10000.0 nM 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 20000.0 nM 10.6019/CHEMBL4513161
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1128/aac.00901-09
Staphylococcus epidermidis Staphylococcus epidermidis IC50 1.0 ug.mL-1 10.1128/aac.00901-09
Staphylococcus epidermidis Staphylococcus epidermidis Inhibition nan % 10.1128/aac.00901-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8.0 ug.mL-1 10.1128/aac.00901-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 16.0 ug.mL-1 10.1128/aac.00901-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1128/aac.00901-09
Staphylococcus haemolyticus Staphylococcus haemolyticus Activity nan None 10.1128/aac.00901-09
Staphylococcus hominis Staphylococcus hominis MIC 32.0 ug.mL-1 10.1128/aac.00901-09
Thomasclavelia ramosa Thomasclavelia ramosa MIC 0.25 ug.mL-1 10.1128/aac.00441-08
Thomasclavelia ramosa Thomasclavelia ramosa MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
Thomasclavelia ramosa Thomasclavelia ramosa MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
Trichomonas vaginalis Trichomonas vaginalis IC50 68.0 nM 10.1016/j.bmc.2014.01.029
Trichomonas vaginalis Trichomonas vaginalis IC50 68.0 nM 10.1016/j.bmc.2015.02.059
Trichomonas vaginalis Trichomonas vaginalis IC50 68.0 nM 10.1016/j.bmcl.2011.02.100
Trichomonas vaginalis Trichomonas vaginalis IC50 68.0 nM 10.1016/j.bmcl.2017.05.071
Trichomonas vaginalis Trichomonas vaginalis IC50 79.43 nM 10.1016/j.bmc.2014.01.029
Trypanosoma brucei brucei (strain 927/4 GUTat10.1) Putative uncharacterized protein Potency 2818.4 nM None
Trypanosoma cruzi Trypanosoma cruzi IC50 18730.0 nM 10.1016/j.bmc.2014.01.029
Trypanosoma cruzi Trypanosoma cruzi IC50 18730.0 nM 10.1016/j.bmcl.2011.02.100
Trypanosoma cruzi Trypanosoma cruzi IC50 18730.0 nM 10.1016/j.bmcl.2017.05.071
Trypanosoma cruzi Trypanosoma cruzi Ratio IC50 2.0 None 10.1016/j.bmc.2014.01.029
Trypanosoma cruzi Trypanosoma cruzi Ratio IC50 2.0 None 10.1016/j.bmcl.2017.05.071
None ADMET AUC 3200.0 ng.hr.mL-1 10.1021/acsmedchemlett.0c00544
None ADMET AUC 11200.0 ng.hr.mL-1 10.1021/acsmedchemlett.0c00544
None ADMET AUC Ratio 1.178 None 10.1038/s41586-020-2286-9
None ADMET CC50 35000.0 nM 10.1021/jm201264t
None ADMET CC50 38000.0 nM 10.1128/aac.00078-08
None ADMET CC50 49000.0 nM 10.1021/jm201264t
None ADMET CC50 68000.0 nM 10.1128/aac.00078-08
None ADMET CC50 97000.0 nM 10.1128/aac.00078-08
None ADMET CC50 100000.0 nM 10.1021/jm200153p
None ADMET CL 8.333 mL.min-1.kg-1 10.1021/acsmedchemlett.0c00544
None ADMET CL 105.0 mL.min-1.kg-1 10.1021/acsmedchemlett.0c00544
None ADMET Cmax 3254.25 nM 10.1021/acsmedchemlett.0c00544
None ADMET Cmax 9111.91 nM 10.1021/acsmedchemlett.0c00544
None ADMET Drugexcretion 33.0 % 10.1016/j.ejmech.2016.09.080
None ADMET Drugexcretion 64.0 % 10.1016/j.ejmech.2016.09.080
None ADMET F 5.7 % 10.1021/acsmedchemlett.0c00544
None ADMET T1/2 0.05 hr 10.1021/acsmedchemlett.0c00544
None ADMET T1/2 0.3 hr 10.1021/acsmedchemlett.0c00544
None ADMET T1/2 0.6 hr 10.1021/acsmedchemlett.0c00544
None ADMET T1/2 0.8 hr 10.1021/acsmedchemlett.0c00544
None ADMET Tmax 2.0 hr 10.1021/acsmedchemlett.0c00544
None ADMET Vd/F 0.08 L.kg-1 10.1021/acsmedchemlett.0c00544
None Erythrocyte HC10 20.0 uM 10.6019/CHEMBL4513161
None Molecular identity unknown Potency 199.5 nM None
None Molecular identity unknown Potency 5955.7 nM None
None Molecular identity unknown Potency 35481.3 nM None
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.00553-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 0.25 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 2.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 4.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC90 0.5 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC90 1.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC90 4.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC90 32.0 ug.mL-1 10.1128/aac.00441-08
None Unchecked Ac50 1.0 uM None
None Unchecked Ac50 22.39 uM None
None Unchecked Ac50 25.12 uM None
None Unchecked Ac50 28.18 uM None
None Unchecked Ac50 31.62 uM None
None Unchecked AC50 1000.0 nM None
None Unchecked AC50 22387.2 nM None
None Unchecked AC50 25118.9 nM None
None Unchecked AC50 28183.8 nM None
None Unchecked AC50 31622.8 nM None
None Unchecked AC50 31630.0 nM None
None Unchecked Activity 8.5 nmol/mg/min 10.1128/aac.01159-06
None Unchecked Activity 18.8 nmol/mg/min 10.1128/aac.01159-06
None Unchecked Activity 19.0 nmol/mg/min 10.1128/aac.01159-06
None Unchecked Activity 41.5 nmol/mg/min 10.1128/aac.01159-06
None Unchecked Activity nan None 10.1021/acsmedchemlett.0c00544
None Unchecked Activity nan None 10.1128/aac.01159-06
None Unchecked EC50 20170.0 nM None
None Unchecked IC50 0.3 ug.mL-1 10.1016/j.bmc.2020.115757
None Unchecked IC50 2061.2 nM None
None Unchecked IC50 10000.0 nM None
None Unchecked IC50 30000.0 nM 10.1021/acsmedchemlett.0c00544
None Unchecked IC50 31800.0 nM 10.1021/acsmedchemlett.0c00544
None Unchecked IC50 91960.0 nM None
None Unchecked IC50 148621.0 nM None
None Unchecked IC50 150000.0 nM None
None Unchecked Inhibition 22.0 % 10.1128/aac.01159-06
None Unchecked Inhibition 31.0 % 10.1016/j.bmc.2015.02.059
None Unchecked Inhibition 54.0 % 10.1016/j.bmcl.2010.04.126
None Unchecked Inhibition 75.0 % 10.1128/aac.01548-06
None Unchecked Inhibition nan % 10.1016/j.bmcl.2014.01.014
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.0c00544
None Unchecked Ki 300.0 nM 10.1128/aac.01548-06
None Unchecked Ki 2200.0 nM 10.1128/aac.01159-06
None Unchecked Ki 4500.0 nM 10.1128/aac.01159-06
None Unchecked Ki 10000.0 nM 10.1128/aac.01159-06
None Unchecked Km 44000.0 nM 10.1128/aac.01159-06
None Unchecked Potency 100.0 nM None
None Unchecked Potency 1995.3 nM None
None Unchecked Potency 6682.4 nM None
None Unchecked Potency 7497.8 nM None
None Unchecked Potency 7943.3 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 23109.3 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 28695.4 nM None
None Unchecked Potency 39810.7 nM None
None Unchecked Ratio CC50/EC50 5.05 None 10.1016/j.bmc.2017.06.049
None Unchecked Ratio CC50/EC50 8.31 None 10.1016/j.bmc.2017.06.049
None Unchecked Ratio CC50/EC50 8.45 None 10.1016/j.bmc.2017.06.049
None Unchecked Ratio CC50/EC50 12.76 None 10.1016/j.bmc.2017.06.049
None Unchecked Ratio CC50/EC50 16.7 None 10.1021/acs.jmedchem.0c00626
None Unchecked Ratio CC50/EC50 57.0 None 10.1128/aac.00078-08
None Unchecked Ratio CC50/EC50 65.0 None 10.1128/aac.00078-08
None Unchecked Ratio CC50/EC50 143.0 None 10.1021/jm201264t
None Unchecked Ratio CC50/EC50 149.0 None 10.1021/jm201264t
None Unchecked Ratio CC50/EC50 238.0 None 10.1128/aac.00078-08
None Unchecked Ratio CC50/IC50 44.0 None 10.1016/j.bmcl.2011.02.100
None Unchecked Ratio CC50/IC50 115.0 None 10.1016/j.bmcl.2017.05.071
None Unchecked Ratio CC50/IC50 135.0 None 10.1016/j.bmcl.2011.02.100
None Unchecked Ratio CC50/IC50 214.0 None 10.1016/j.bmcl.2011.02.100
None Unchecked Ratio CC50/IC50 686.0 None 10.1016/j.bmc.2014.01.029
None Unchecked Ratio CC50/IC50 686.0 None 10.1016/j.bmcl.2011.02.100
None Unchecked Ratio CC50/IC50 686.0 None 10.1016/j.bmcl.2017.05.071
None Unchecked Ratio CC50/IC50 1653.0 None 10.1016/j.bmcl.2011.02.100
None Unchecked Ratio CC50/IC50 12250.0 None 10.1016/j.bmc.2014.01.029
None Unchecked Ratio CC50/IC50 12250.0 None 10.1016/j.bmcl.2011.02.100
None Unchecked Ratio CC50/IC50 12250.0 None 10.1016/j.bmcl.2017.05.071
None Unchecked Ratio IC50 2.75 None 10.1016/j.bmc.2013.05.036
None Unchecked Selectivity Index 2.8 None 10.1021/acsmedchemlett.0c00544
None Unchecked Selectivity Index 48.0 None 10.1021/jm200153p
None Unchecked Selectivity Index 121.0 None 10.1021/jm200153p
None Unchecked T1/2 7.3 hr 10.1021/acs.jmedchem.0c00910

Metabolism Information