Pyrroloformamide C
AlkaPlorer ID: AK322766
Synonym: None
IUPAC Name: N-methyl-N-(6-oxo-5H-[1,3]dithiino[5,4-b]pyrrol-7-yl)formamide
Structure
SMILES: CN(C=O)C1=C2SCSC=C2NC1=O
InChI: InChI=1S/C8H8N2O2S2/c1-10(3-11)6-7-5(9-8(6)12)2-13-4-14-7/h2-3H,4H2,1H3,(H,9,12)
InChIKey: HGDYHOGWEAAXCS-UHFFFAOYSA-N
Reference
The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster
PubChem CID: 156016937
NPASS: NPC478924
{NPAtlas: NPA029604
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. CB02980 | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 228.298
TPSA？: 49.41
MolLogP？: 0.6949
Number of H-Donors: 1
Number of H-Acceptors: 4
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Escherichia coli | Escherichia coli | MIC | 64.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00321 |
| Homo sapiens | A549 | IC50 | 64000.0 | nM | 10.1021/acs.jnatprod.9b00321 |
| Homo sapiens | Caco-2 | IC50 | 64000.0 | nM | 10.1021/acs.jnatprod.9b00321 |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC | 64.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00321 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 64.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00321 |