Pyrroloformamide D
AlkaPlorer ID: AK322767
Synonym: None
IUPAC Name: N-methyl-N-(1,1,5-trioxo-4H-dithiolo[4,3-b]pyrrol-6-yl)formamide
Structure
SMILES: CN(C=O)C1=C2C(=CSS2(=O)=O)NC1=O
InChI: InChI=1S/C7H6N2O4S2/c1-9(3-10)5-6-4(8-7(5)11)2-14-15(6,12)13/h2-3H,1H3,(H,8,11)
InChIKey: MXCMXGBEQPSSNS-UHFFFAOYSA-N
Reference
The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster
PubChem CID: 156011184
NPASS: NPC478925
{NPAtlas: NPA029605
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. CB02980 | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 246.269
TPSA？: 83.55000000000001
MolLogP？: -0.6660000000000001
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Escherichia coli | Escherichia coli | MIC | 32.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00321 |
| Homo sapiens | A549 | IC50 | 64000.0 | nM | 10.1021/acs.jnatprod.9b00321 |
| Homo sapiens | Caco-2 | IC50 | 64000.0 | nM | 10.1021/acs.jnatprod.9b00321 |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC | 64.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00321 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 8.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00321 |