Molecule

None

AlkaPlorer ID: AK322768

Synonym: None

IUPAC Name: [2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol

Structure

SMILES: N=C1N=C(NC2=CC=C([As]3SCC(CO)S3)C=C2)NC(=N)N1

InChI: InChI=1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)

InChIKey: JCYZMTMYPZHVBF-UHFFFAOYSA-N

Reference

Nonpolar Components of the Latex of Euphorbia peplus

PubChem CID: 10311

CAS: 494-79-1

NPASS: NPC478929

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Tarchonanthus camphoratus	Tarchonanthus	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Xenorhabdus nematophila	Xenorhabdus	Morganellaceae	Enterobacterales	Gammaproteobacteria	Pseudomonadota	None	Bacteria
Schkuhria pinnata	Schkuhria	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Salvia hydrangea	Salvia	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Cussonia zimmermannii	Cussonia	Araliaceae	Apiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ancistrocladus ileboensis	Ancistrocladus	Ancistrocladaceae	Caryophyllales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Salvia leriifolia	Salvia	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Chamaemelum nobile	Chamaemelum	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ircinia oros	Ircinia	Irciniidae	Dictyoceratida	Demospongiae	Porifera	Metazoa	Eukaryota
Ancistrocladus abbreviatus	Ancistrocladus	Ancistrocladaceae	Caryophyllales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ancistrocladus ealaensis	Ancistrocladus	Ancistrocladaceae	Caryophyllales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Escherichia coli	Escherichia	Enterobacteriaceae	Enterobacterales	Gammaproteobacteria	Pseudomonadota	None	Bacteria

Properties Information

Molecule Weight: 398.349

TPSA？: 124.42999999999998

MolLogP？: -0.0235600000000003

Number of H-Donors: 6

Number of H-Acceptors: 7

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Babesia divergens	Babesia divergens	IC50	nan	None	10.1128/aac.00225-07
Giardia intestinalis	Giardia intestinalis	IC50	nan	None	10.1128/aac.00225-07
Homo sapiens	Acetylcholinesterase	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A3 receptor	AC50	1918.4	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Androgen Receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cathepsin B	Inhibition	nan	%	10.1021/jm900629w
Homo sapiens	Cathepsin B	Ki	nan	None	10.1021/jm900629w
Homo sapiens	Cyclooxygenase-1	AC50	23487.7	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cyclooxygenase-1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine transporter	AC50	29170.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	HERG	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	HL-60	EC50	4270.0	nM	10.1128/aac.01418-06
Homo sapiens	HL-60	MIC	100000.0	nM	10.1128/aac.01418-06
Homo sapiens	Homo sapiens	mortality	5.9	%	10.1021/acs.jmedchem.5b00438
Homo sapiens	HT-29	IC50	3.6	ug.mL-1	10.1021/np970517x
Homo sapiens	HT-29	MIC	11.0	ug.mL-1	10.1021/np970517x
Homo sapiens	Liver microsome	Stability	84.0	%	10.1016/j.bmc.2014.08.005
Homo sapiens	Monoamine oxidase A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	MRC5	CC50	12500.0	nM	10.1016/s0960-894x(02)00788-6
Homo sapiens	MRC5	CC50	12500.0	nM	10.1021/jm990946n
Homo sapiens	Mu opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M1	AC50	22496.8	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Norepinephrine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 3A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 4A	AC50	14530.5	nM	10.1038/s41467-023-40064-9
Homo sapiens	Plasma	Stability	100.0	%	10.1016/j.bmc.2014.08.005
Homo sapiens	Progesterone receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Thrombin	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Thromboxane A2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Leishmania donovani	Leishmania donovani	IC50	0.2	ug.mL-1	10.1016/j.bmcl.2019.126642
Leishmania donovani	Leishmania donovani	IC50	33.26	ug.mL-1	10.1016/j.bmcl.2019.126642
Leishmania donovani	Leishmania donovani	IC50	7800.0	nM	10.1021/jm050177+
Leishmania donovani	Leishmania donovani	IC50	30000.0	nM	10.1128/aac.00425-07
Leishmania donovani	Leishmania donovani	IC50	nan	None	10.1016/j.bmcl.2005.11.025
Leishmania donovani	Leishmania donovani	IC50	nan	None	10.1128/aac.00225-07
Mus musculus	J774	IC50	4300.0	nM	10.1016/j.bmcl.2006.02.026
Mus musculus	J774	Ratio IC50	1653.0	None	10.1016/j.bmcl.2006.02.026
Mus musculus	Liver	Stability	72.0	%	10.1016/j.bmc.2014.08.005
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm901178d
Mus musculus	Mus musculus	Cured/Infected	0.0	None	10.1021/jm050177+
Mus musculus	Mus musculus	Cured/Infected	2.0	None	10.1021/jm050177+
Mus musculus	Mus musculus	Cured/Infected	4.0	None	10.1021/jm050177+
Mus musculus	Mus musculus	Cured/Infected	nan	None	10.1021/jm050177+
Mus musculus	Mus musculus	LD50	0.00875	umol.kg-1	10.1016/j.ejmech.2018.05.017
Mus musculus	Mus musculus	Mean no. of days post-infection to death	nan	None	10.1021/jm981130+
Mus musculus	Mus musculus	Survival	21.25	day	10.1021/jm050177+
Mus musculus	Mus musculus	Survival	60.0	day	10.1021/jm050177+
Mus musculus	Mus musculus	Survival	nan	None	10.1021/jm050177+
Mus musculus	Plasma	Stability	100.0	%	10.1016/j.bmc.2014.08.005
Plasmodium falciparum	Plasmodium falciparum	IC50	5500.0	nM	10.1021/jm7013088
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1016/j.bmcl.2006.07.057
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1021/jm900946n
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1128/aac.00225-07
Rattus norvegicus	GABA receptor alpha-1 subunit	AC50	20977.8	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	L6	CC50	28900.0	nM	10.1021/acs.jmedchem.8b01464
Rattus norvegicus	L6	IC50	1.3	ug.mL-1	10.1016/j.ejmech.2011.01.071
Rattus norvegicus	L6	IC50	5100.0	nM	10.1016/j.ejmech.2014.06.022
Rattus norvegicus	L6	IC50	5120.0	nM	10.1016/j.bmc.2013.10.050
Rattus norvegicus	L6	IC50	5120.0	nM	10.1016/j.bmc.2016.04.006
Rattus norvegicus	L6	IC50	5120.0	nM	10.1021/jm400508e
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmc.2007.05.042
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmc.2008.05.007
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmc.2009.04.002
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmc.2010.02.034
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmc.2013.06.059
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmc.2016.06.024
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmcl.2006.07.057
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.bmcl.2015.02.044
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.ejmech.2007.06.007
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.ejmech.2011.11.022
Rattus norvegicus	L6	IC50	7780.0	nM	10.1016/j.ejmech.2020.112969
Rattus norvegicus	L6	IC50	7780.0	nM	10.1021/jm0708634
Rattus norvegicus	L6	IC50	7780.0	nM	10.1021/jm800918v
Rattus norvegicus	L6	IC50	7780.0	nM	10.1021/jm801547t
Rattus norvegicus	L6	IC50	7780.0	nM	10.1021/jm900805v
Rattus norvegicus	L6	IC50	7780.0	nM	10.1021/jm901178d
Rattus norvegicus	L6	IC50	7800.0	nM	10.1016/j.ejmech.2009.03.014
Rattus norvegicus	L6	IC50	7800.0	nM	10.1021/jm050177+
Rattus norvegicus	L6	IC50	7900.0	nM	10.1021/jm900723w
Rattus norvegicus	L6	IC50	8600.0	nM	10.1016/j.bmc.2009.08.057
Rattus norvegicus	L6	IC50	18300.0	nM	10.1021/acs.jmedchem.5b00748
Rattus norvegicus	L6	IC50	18300.0	nM	10.1021/jm301112z
Rattus norvegicus	L6	IC50	19000.0	nM	10.1016/j.bmcl.2013.12.064
Rattus norvegicus	L6	IC50	24200.0	nM	10.1016/j.bmc.2019.115185
Rattus norvegicus	L6	IC50	29000.0	nM	10.1016/j.bmc.2017.02.016
Rattus norvegicus	L6	IC50	29100.0	nM	10.1016/j.bmc.2015.02.005
Rattus norvegicus	L6	IC50	7780000.0	nM	10.1016/j.ejmech.2013.06.033
Rattus norvegicus	L6	IC50	nan	None	10.1016/j.bmc.2010.11.003
Rattus norvegicus	L6	Ratio	3456.0	None	10.1021/jm031024u
Rattus norvegicus	Rattus norvegicus	IC50	7780.0	nM	10.1016/j.bmc.2016.12.006
Trichomonas vaginalis	Trichomonas vaginalis	MAC	nan	None	10.1016/j.bmcl.2005.11.025
Trypanosoma brucei	Trypanosoma brucei	EC50	33.0	nM	10.1016/j.bmc.2011.12.018
Trypanosoma brucei	Trypanosoma brucei	ED50	0.2	uM	10.1016/s0960-894x(02)00788-6
Trypanosoma brucei	Trypanosoma brucei	GI50	3.8	nM	10.1016/j.bmc.2012.11.009
Trypanosoma brucei	Trypanosoma brucei	IC50	10.0	nM	10.1021/np300834q
Trypanosoma brucei	Trypanosoma brucei	IC50	200.0	nM	10.1021/jm990946n
Trypanosoma brucei	Trypanosoma brucei	IC50	4000.0	nM	10.1128/aac.01213-09
Trypanosoma brucei	Trypanosoma brucei	IC50	nan	None	10.1016/j.bmc.2010.11.003
Trypanosoma brucei	Trypanosoma brucei	Min lytic concentration	100.0	uM	10.1021/jm00348a009
Trypanosoma brucei brucei	Nucleoside transporter 2	P2 uptake	1.2	None	10.1021/jm050177+
Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	6.3	nM	10.1021/jm400349k
Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	16.0	nM	10.1128/aac.01418-06
Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	nan	None	10.1021/jm301687p
Trypanosoma brucei brucei	Trypanosoma brucei brucei	ED50	0.00395	uM	10.1016/j.bmcl.2010.04.145
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	0.002	ug.mL-1	10.1021/np020362f
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	0.0036	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	0.0187	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	2.6	nM	10.1016/j.bmcl.2006.02.026
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	2.6	nM	10.1021/jm101439s
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	2.6	nM	10.1021/jm900629w
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	3.4	nM	10.1016/j.ejmech.2014.09.045
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	3.4	nM	10.1021/jm300508n
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	4.0	nM	10.1016/j.bmc.2010.02.034
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	6.0	nM	10.1016/j.ejmech.2014.09.045
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	30.0	nM	10.1016/j.bmc.2014.08.005
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	30.0	nM	10.1016/j.ejmech.2017.11.075
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	53.0	nM	10.1021/jm050177+
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	120.0	nM	10.1021/jm050177+
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	nan	None	10.1016/j.bmc.2011.01.010
Trypanosoma brucei brucei	Trypanosoma brucei brucei	MAC	0.1	uM	10.1016/j.bmcl.2005.11.025
Trypanosoma brucei brucei	Trypanosoma brucei brucei	Mean survival days	42.5	day	10.1016/j.bmcl.2006.07.057
Trypanosoma brucei brucei	Trypanosoma brucei brucei	MIC	100.0	nM	10.1128/aac.01418-06
Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio IC50	1.0	None	10.1016/j.ejmech.2014.09.045
Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio IC50	1.0	None	10.1021/jm300508n
Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio IC50	5.2	None	10.1128/aac.00225-09
Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio IC50	10.0	None	10.1016/j.bmcl.2013.05.086
Trypanosoma brucei brucei	Trypanosoma brucei brucei	Survival	100.0	%	10.1021/jm201091t
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	EC50	6.7	nM	10.1021/jm301687p
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	EC50	12.0	nM	10.1021/jm301687p
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	EC50	14.0	nM	10.1021/jm301687p
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	0.0027	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	0.0031	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	0.0053	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	5.0	nM	10.1016/j.ejmech.2018.05.017
Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	Ratio IC50	14.0	None	10.1128/aac.00225-09
Trypanosoma brucei rhodesiense	Rhodesain	IC50	nan	None	10.1016/j.bmc.2010.02.034
Trypanosoma brucei rhodesiense	Rhodesain	Inhibition	94.0	%	10.1021/jm900629w
Trypanosoma brucei rhodesiense	Rhodesain	Inhibition	94.3	%	10.1016/j.bmcl.2006.02.026
Trypanosoma brucei rhodesiense	Rhodesain	Inhibition	nan	%	10.1021/jm900629w
Trypanosoma brucei rhodesiense	Rhodesain	Ki	nan	None	10.1021/jm900629w
Trypanosoma brucei rhodesiense	Rhodesain	Ki	nan	None	10.1021/jm900946n
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	20.0	day	10.1021/jm901178d
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	nan	None	10.1016/j.bmc.2013.10.050
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	nan	None	10.1016/j.ejmech.2009.03.014
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	nan	None	10.1016/j.ejmech.2013.06.033
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	nan	None	10.1021/jm400508e
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	nan	None	10.1021/jm800918v
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	nan	None	10.1021/jm801547t
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	nan	None	10.1021/jm900805v
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	EC50	7.2	nM	10.1021/jm301687p
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	EC50	7.5	nM	10.1021/jm2014259
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	EC50	7.8	nM	10.1021/jm301215e
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	EC50	17.0	nM	10.1016/j.bmcl.2010.02.022
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	GI	44.4	%	10.1016/j.bmcl.2017.07.081
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	GI	98.3	%	10.1016/j.bmcl.2017.07.081
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0004	ug.mL-1	10.1021/np970517x
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0005	ug.mL-1	10.1021/np020362f
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.00095	ug.mL-1	10.1021/np049626j
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.00095	ug.mL-1	10.1021/np0497651
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.001	ug.mL-1	10.1016/j.bmcl.2019.126642
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.001	ug.mL-1	10.1021/np030077b
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0014	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.002	ug.mL-1	10.1021/jm500191u
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0026	ug.mL-1	10.1021/jm0110892
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0026	ug.mL-1	10.1021/np990502u
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0027	ug.mL-1	10.1016/j.bmc.2007.07.032
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.003	ug.mL-1	10.1016/j.bmc.2010.08.055
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.003	ug.mL-1	10.1016/j.ejmech.2008.10.003
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.003	ug.mL-1	10.1016/j.ejmech.2021.113545
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.003	ug.mL-1	10.1021/np010622d
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.003	ug.mL-1	10.1128/aac.00225-07
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0031	ug.mL-1	10.1021/np0340549
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0038	ug.mL-1	10.1021/np0496284
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.004	ug.mL-1	10.1021/np0680230
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.004	ug.mL-1	10.1021/np800294q
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.005	ug.mL-1	10.1016/j.ejmech.2011.12.028
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.005	ug.mL-1	10.1021/jm2015183
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.005	ug.mL-1	10.1021/np020362f
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0063	ug.mL-1	10.1021/np000247+
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0282	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.04	ug.mL-1	10.1016/j.bmcl.2019.126642
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	0.0567	ug.mL-1	10.1128/aac.00225-09
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.0	nM	10.1016/j.bmcl.2014.12.048
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.0	nM	10.1021/acs.jnatprod.7b00747
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.8	nM	10.1016/j.bmcl.2013.12.064
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.bmc.2007.05.042
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.bmc.2008.05.007
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.bmc.2009.04.002
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.bmc.2016.06.024
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.bmcl.2006.07.057
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.bmcl.2015.02.044
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.ejmech.2007.06.007
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	3.9	nM	10.1016/j.ejmech.2020.112969
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1016/j.bmc.2013.10.050
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1016/j.ejmech.2014.06.022
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/jm0708634
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/jm400508e
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/jm800918v
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/jm801547t
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/jm900805v
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/jm901112f
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/jm901178d
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4.0	nM	10.1021/np400337a
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1016/j.bmc.2015.02.005
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1016/j.bmc.2016.06.047
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1016/j.bmcl.2012.06.004
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1016/j.bmcl.2012.11.072
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1016/j.ejmech.2008.05.002
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1016/j.ejmech.2013.05.007
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1016/j.ejmech.2017.01.027
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1021/acs.jnatprod.9b00932
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1021/jm300887b
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1021/jm401007p
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1021/jm5018303
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.0	nM	10.1021/np200509g
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.5	nM	10.1021/jm301614w
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.6	nM	10.1128/aac.00425-07
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5.8	nM	10.1021/np0702133
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.0	nM	10.1016/j.bmcl.2011.07.112
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.0	nM	10.1016/j.bmcl.2014.12.051
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.0	nM	10.1016/j.ejmech.2013.06.033
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.0	nM	10.1016/j.ejmech.2020.112837
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.0	nM	10.1021/jm050177+
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.0	nM	10.1021/jm8003619
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.0	nM	10.1039/C2MD20136D
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.026	nM	10.1016/j.ejmech.2020.112837
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.4	nM	10.1016/j.ejmech.2009.03.014
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6.4	nM	10.1021/jm0612867
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.0	nM	10.1016/j.bmcl.2019.126778
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.0	nM	10.1016/j.ejmech.2010.08.062
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.0	nM	10.1021/acs.jnatprod.9b00589
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.0	nM	10.1021/acs.jnatprod.9b00755
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.0	nM	10.1021/jm5015742
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1016/j.bmc.2019.115185
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1016/j.bmcl.2012.08.019
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1016/j.bmcl.2023.129258
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1021/acs.jnatprod.6b00967
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1021/acs.jnatprod.7b00650
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1021/acs.jnatprod.7b01041
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1021/ml400039r
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	7.5	nM	10.1128/aac.00124-09
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	8.0	nM	10.1016/j.bmc.2009.11.010
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	8.0	nM	10.1016/j.ejmech.2014.04.083
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	8.0	nM	10.1016/j.ejmech.2017.07.060
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	8.0	nM	10.1021/acs.jmedchem.1c00483
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	8.0	nM	10.1021/jm900723w
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	8.8	nM	10.1016/j.ejmech.2018.06.063
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	8.8	nM	10.1021/acs.jmedchem.8b01464
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.0	nM	10.1016/j.bmc.2013.06.059
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.0	nM	10.1016/j.bmc.2015.08.014
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.0	nM	10.1016/j.ejmech.2011.01.071
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.0	nM	10.1016/j.ejmech.2011.11.022
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.0	nM	10.1016/j.ejmech.2015.08.042
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.0	nM	10.1016/j.ejmech.2016.04.010
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.0	nM	10.1016/j.ejmech.2016.08.002
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	9.9	nM	10.1016/j.bmc.2010.11.003
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.bmc.2009.08.057
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.bmc.2011.10.039
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.bmc.2011.12.053
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.bmc.2017.02.016
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.bmcl.2008.03.009
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.bmcl.2009.04.060
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.ejmech.2009.02.010
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1016/j.ejmech.2017.11.025
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/acs.jmedchem.5b00748
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/acs.jnatprod.6b00980
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/acs.jnatprod.7b01019
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/jm201215n
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/jm301112z
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/jm700938n
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/np100348x
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/np100415m
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/np1008619
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/np4007525
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/np500390b
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1021/np5006554
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	10.0	nM	10.1039/C4MD00406J
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	11.0	nM	10.1016/j.bmc.2013.08.022
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	11.0	nM	10.1016/j.ejmech.2020.112871
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	12.0	nM	10.1021/jm300508n
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	12.0	nM	10.1021/np100625a
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	13.0	nM	10.1016/j.bmcl.2011.08.116
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	14.0	nM	10.1039/d0md00277a
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	15.0	nM	10.1021/acs.jnatprod.1c00063
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	15.0	nM	10.1021/acs.jnatprod.7b00543
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	17.0	nM	10.1128/aac.01568-08
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	20.0	nM	10.1016/j.bmc.2014.08.005
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	20.0	nM	10.1016/j.ejmech.2017.11.075
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	20.0	nM	10.1021/acs.jnatprod.8b00425
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	26.0	nM	10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	40.0	nM	10.1021/acs.jnatprod.8b00498
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	44.0	nM	10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	51.0	nM	10.1016/j.ejmech.2015.11.043
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	86.0	nM	10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	99.0	nM	10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	130.0	nM	10.1021/jm700938n
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	180.0	nM	10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	4000.0	nM	10.1016/j.bmc.2016.04.006
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	5500.0	nM	10.1021/jm031024u
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Inhibition	98.2	%	10.1016/j.ejmech.2010.05.055
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	MIC	0.011	ug.mL-1	10.1021/np049640w
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	MIC	0.011	ug.mL-1	10.1021/np970517x
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	MSD	60.0	day	10.1016/j.bmc.2013.10.050
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	MSD	60.0	day	10.1016/j.ejmech.2013.06.033
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	MSD	60.0	day	10.1021/jm400508e
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Ratio IC50	20.9	None	10.1128/aac.00225-09
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Ratio IC50	42.0	None	10.1128/aac.00225-09
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	51.5	day	10.1021/jm800918v
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	51.5	day	10.1021/jm801547t
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	51.5	day	10.1021/jm900805v
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	60.0	day	10.1016/j.ejmech.2009.03.014
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	60.0	day	10.1021/jm800918v
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	60.0	day	10.1021/jm801547t
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	60.0	day	10.1021/jm900805v
Trypanosoma cruzi	Trypanosoma cruzi	IC50	0.36	ug.mL-1	10.1016/j.bmcl.2019.126642
Trypanosoma cruzi	Trypanosoma cruzi	IC50	0.6	ug.mL-1	10.1021/jm0110892
Trypanosoma cruzi	Trypanosoma cruzi	IC50	4.1	nM	10.1128/aac.00425-07
Trypanosoma cruzi	Trypanosoma cruzi	IC50	5.42	ug.mL-1	10.1016/j.bmcl.2019.126642
Trypanosoma cruzi	Trypanosoma cruzi	IC50	6.0	nM	10.1021/jm050177+
Trypanosoma cruzi	Trypanosoma cruzi	IC50	18.0	nM	10.1128/aac.00425-07
Trypanosoma cruzi	Trypanosoma cruzi	IC50	30000.0	nM	10.1128/aac.00425-07
Trypanosoma cruzi	Trypanosoma cruzi	IC50	nan	None	10.1128/aac.00225-07
Trypanosoma cruzi	Trypanosoma cruzi	MIC	0.011	ug.mL-1	10.1021/np049640w
Trypanosoma cruzi	Trypanosoma cruzi	Ratio IC50	4.4	None	10.1128/aac.00425-07
None	ADMET	IC50	7400.0	nM	10.1016/j.bmc.2014.08.005
None	NON-PROTEIN TARGET	Hepatotoxicity (acute)	0.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (animal toxicity known)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (benign tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (granulomatous hepatitis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (mechanism)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	1.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	3.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (time to onset)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	IC50	10.0	nM	10.1016/j.bmc.2016.12.006
None	No relevant target	Drug recovery	100.0	%	10.1016/j.bmc.2014.08.005
None	No relevant target	LogD	4.51	None	10.1016/j.bmc.2014.08.005
None	No relevant target	Solubility	25000.0	nM	10.1016/j.bmc.2014.08.005
None	Unchecked	Hepatotoxicity (acute)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (association with vascular disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (choleostasis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (chronic liver disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cirrhosis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (comment)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cytolytic)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (malignant tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (severe hepatitis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (steatosis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (successful reintroduction)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	IC50	7400.0	nM	10.1016/j.ejmech.2017.11.075
None	Unchecked	IC50	nan	None	10.1016/j.bmc.2010.02.034
None	Unchecked	Ki	nan	None	10.1021/jm900946n
None	Unchecked	Ratio	1000.0	None	10.1128/aac.01418-06
None	Unchecked	Ratio CC50/IC50	1000.0	None	10.1016/j.ejmech.2014.04.083
None	Unchecked	Ratio EC50	267.0	None	10.1128/aac.01418-06
None	Unchecked	Ratio IC50	2.0	None	10.1128/aac.00225-09
None	Unchecked	Ratio IC50	2.3	None	10.1128/aac.00225-09
None	Unchecked	Ratio IC50	3.9	None	10.1128/aac.00225-09
None	Unchecked	Ratio IC50	193.1	None	10.1016/j.bmcl.2011.08.116
None	Unchecked	Ratio IC50	778.0	None	10.1016/j.bmc.2016.12.006
None	Unchecked	Ratio IC50	1000.0	None	10.1021/jm900723w
None	Unchecked	Ratio IC50	1220.0	None	10.1016/j.ejmech.2009.03.014
None	Unchecked	Ratio IC50	1222.0	None	10.1016/j.ejmech.2013.06.033
None	Unchecked	Ratio IC50	1275.0	None	10.1016/j.bmc.2013.10.050
None	Unchecked	Ratio IC50	1275.0	None	10.1016/j.ejmech.2014.06.022
None	Unchecked	Ratio IC50	1275.0	None	10.1021/jm400508e
None	Unchecked	Ratio IC50	1280.0	None	10.1016/j.bmc.2016.04.006
None	Unchecked	Ratio IC50	1830.0	None	10.1021/acs.jmedchem.5b00748
None	Unchecked	Ratio IC50	1830.0	None	10.1021/jm301112z
None	Unchecked	Ratio IC50	1945.0	None	10.1016/j.bmc.2010.02.034
None	Unchecked	Ratio IC50	1945.0	None	10.1016/j.bmc.2013.06.059
None	Unchecked	Ratio IC50	1945.0	None	10.1016/j.ejmech.2011.11.022
None	Unchecked	Ratio IC50	1945.0	None	10.1021/jm0708634
None	Unchecked	Ratio IC50	1945.0	None	10.1021/jm800918v
None	Unchecked	Ratio IC50	1945.0	None	10.1021/jm801547t
None	Unchecked	Ratio IC50	1945.0	None	10.1021/jm900805v
None	Unchecked	Ratio IC50	1945.0	None	10.1021/jm901178d
None	Unchecked	Ratio IC50	1995.0	None	10.1016/j.bmc.2007.05.042
None	Unchecked	Ratio IC50	1995.0	None	10.1016/j.bmc.2008.05.007
None	Unchecked	Ratio IC50	1995.0	None	10.1016/j.bmc.2009.04.002
None	Unchecked	Ratio IC50	1995.0	None	10.1016/j.bmc.2016.06.024
None	Unchecked	Ratio IC50	1995.0	None	10.1016/j.bmcl.2006.07.057
None	Unchecked	Ratio IC50	1995.0	None	10.1016/j.bmcl.2015.02.044
None	Unchecked	Ratio IC50	1995.0	None	10.1016/j.ejmech.2020.112969
None	Unchecked	Ratio IC50	3227.0	None	10.1016/j.bmc.2019.115185
None	Unchecked	Ratio IC50	3284.1	None	10.1021/acs.jmedchem.8b01464
None	Unchecked	Ratio IC50	5000.0	None	10.1016/j.bmc.2015.02.005
None	Unchecked	Ratio IC50	9000.0	None	10.1021/np970517x
None	Unchecked	Ratio IC50	nan	None	10.1016/j.bmcl.2011.07.112
None	Unchecked	Ratio IC50	nan	None	10.1039/C2MD20136D