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(5S)-5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

AlkaPlorer ID: AK322815

Synonym: None

IUPAC Name: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

Structure

SMILES: CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)N=C3O)C=C2)N=C1

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InChI: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)

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InChIKey: HYAFETHFCAUJAY-UHFFFAOYSA-N

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Reference

PubChem CID: 4829

CAS: 105355-27-9

NPASS: NPC479118

COCONUT: CNP0220687.2

Properties Information

Molecule Weight: 356.44700000000006

TPSA？: 71.78

MolLogP？: 3.999900000000003

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus aethiops COS-7 Activity nan None 10.1016/j.ejmech.2020.112258
Chlorocebus sabaeus Vero C1008 AUC cytotoxicity 236.6 None 10.1038/s41586-020-2286-9
Chlorocebus sabaeus Vero C1008 pCC50 5.44 None 10.1038/s41586-020-2286-9
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) Enoyl-[acyl-carrier-protein] reductase [NADH] IC50 79000.0 nM 10.1021/jm4001242
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None 10.1021/acs.jmedchem.0c01874
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 15848.9 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 7050.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 100.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 260.0 nM 10.1021/acs.jmedchem.0c00524
Homo sapiens Bile salt export pump IC50 262.1 nM 10.1124/dmd.112.047068
Homo sapiens Bile salt export pump IC50 300.0 nM 10.1124/dmd.111.040758
Homo sapiens Bile salt export pump IC50 400.0 nM 10.1002/hep.27206
Homo sapiens Bile salt export pump IC50 400.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 400.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity nan None 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 114.0 nM None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Carnitine O-palmitoyltransferase 1, liver isoform IC50 10000.0 nM 10.6019/CHEMBL3431459
Homo sapiens Carnitine O-palmitoyltransferase 1, muscle isoform IC50 100000.0 nM 10.6019/CHEMBL3431459
Homo sapiens Carnitine palmitoyltransferase 2 IC50 100000.0 nM 10.6019/CHEMBL3431459
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM Activity 0.0 % 10.1021/acs.jmedchem.1c00491
Homo sapiens CDGSH iron-sulfur domain-containing protein 1 IC50 8650.0 nM 10.1016/j.bmcl.2016.09.009
Homo sapiens CDGSH iron-sulfur domain-containing protein 1 Ki 370.0 nM 10.1016/j.bmcl.2016.09.009
Homo sapiens CDGSH iron-sulfur domain-containing protein 2 Activity 13.0 % 10.1016/j.bmcl.2019.01.041
Homo sapiens CDGSH iron-sulfur domain-containing protein 2 IC50 4800.0 nM 10.1016/j.bmcl.2019.01.041
Homo sapiens CDGSH iron-sulfur domain-containing protein 2 Inhibition nan % 10.1016/j.bmcl.2019.01.041
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 Activity 26.0 % 10.1021/acs.jmedchem.0c02245
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2B6 Inhibition 38.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C8 Activity nan None None
Homo sapiens Cytochrome P450 2C8 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C9 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition 61.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dipeptidyl peptidase IV IC50 nan None 10.1016/j.ejmech.2019.111808
Homo sapiens Dipeptidyl peptidase IV Inhibition nan % 10.1016/j.ejmech.2019.111808
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 2511.9 nM None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 15889.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Epoxide hydratase IC50 nan None 10.1021/acs.jmedchem.5b01239
Homo sapiens Epoxide hydratase IC50 nan None 10.1021/jm301194c
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Free fatty acid receptor 1 EC50 812830.52 nM 10.1016/j.bmcl.2014.07.043
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HEK293 Activity nan None 10.1016/j.bmcl.2017.04.061
Homo sapiens HeLa Activity 0.0 % 10.1021/acs.jmedchem.1c00491
Homo sapiens HepG2 Activity 2.92 mM 10.1016/j.bmcl.2021.128410
Homo sapiens HepG2 Activity 43.3 % 10.1016/j.bmcl.2021.128410
Homo sapiens HepG2 Activity 64.1 % 10.1016/j.bmc.2019.115263
Homo sapiens HepG2 Activity nan None 10.1016/j.bmcl.2015.03.020
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition 4.75 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 5.6 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity nan None 10.1002/hep.27206
Homo sapiens Homo sapiens AUC 7998.74 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens Cmax 2946.0 nM 10.1002/hep.27206
Homo sapiens Homo sapiens Css 0.935 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fa 83.0 % 10.1016/j.bmc.2015.03.071
Homo sapiens HOP-62 GI50 nan None 10.1016/j.bmcl.2020.127561
Homo sapiens HT-1080 Activity nan None 10.1016/j.ejmech.2017.03.052
Homo sapiens HT-1080 IC50 100000.0 nM 10.1016/j.ejmech.2017.03.052
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K562 Activity nan None 10.1016/j.ejmech.2021.113285
Homo sapiens K562 GI50 40070.0 nM 10.1016/j.bmcl.2020.127561
Homo sapiens K562-IMA[r] Activity nan None 10.1016/j.ejmech.2019.111748
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KB GI50 nan None 10.1016/j.bmcl.2020.127561
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsome CLH nan None 10.1124/dmd.111.039180
Homo sapiens Liver microsome Drug metabolism nan None 10.1124/dmd.111.039180
Homo sapiens Liver microsome PB 353.0 pmol 10.1124/dmd.111.039180
Homo sapiens Liver microsomes Activity 295.0 pmol 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens Lysine-specific histone demethylase 1 Inhibition nan % 10.1021/ml200196p
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 GI50 nan None 10.1016/j.bmcl.2020.127561
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.ejmech.2017.03.052
Homo sapiens MDA-MB-231 IC50 100000.0 nM 10.1016/j.ejmech.2017.03.052
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Mesenchymal stem cells EC50 790.0 nM 10.1021/acs.jnatprod.2c00791
Homo sapiens Mesenchymal stem cells EC50 900.0 nM 10.1021/acsmedchemlett.2c00159
Homo sapiens Mesenchymal stem cells FC 7.8 None 10.1021/acsmedchemlett.2c00159
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 35069.0 nM None
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1021/ml200196p
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Monoamine oxidase B Delta Tm 2.5 degrees C 10.1016/j.bmc.2014.12.063
Homo sapiens Monoamine oxidase B IC50 298.0 nM 10.1016/j.bmcl.2010.06.128
Homo sapiens Monoamine oxidase B IC50 298.0 nM 10.1016/j.bmcl.2022.128994
Homo sapiens Monoamine oxidase B Kd nan None 10.1016/j.bmc.2014.12.063
Homo sapiens Monoamine oxidase B Ki 199.4 nM 10.1016/j.bmc.2014.12.063
Homo sapiens Monoamine oxidase B Ki 270.8 nM 10.1016/j.bmc.2014.12.063
Homo sapiens Monoamine oxidase B Ki 500.0 nM 10.1021/ml200196p
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 49500.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens PC-3 Activity nan None 10.1016/j.ejmech.2017.03.052
Homo sapiens PC-3 FC 0.882 None 10.1038/nchembio790
Homo sapiens PC-3 GI50 nan None 10.1016/j.bmcl.2020.127561
Homo sapiens PC-3 IC50 100000.0 nM 10.1016/j.ejmech.2017.03.052
Homo sapiens Peroxisome proliferator-activated receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Peroxisome proliferator-activated receptor alpha Activity 3.5 % 10.1021/acs.jmedchem.0c01874
Homo sapiens Peroxisome proliferator-activated receptor alpha Activity nan None 10.1016/j.bmc.2019.05.028
Homo sapiens Peroxisome proliferator-activated receptor alpha Activity nan None 10.1016/j.bmcl.2010.03.008
Homo sapiens Peroxisome proliferator-activated receptor alpha Activity nan None 10.1021/jm301194c
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 6680.0 nM 10.1021/jm010964g
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 6680.0 nM 10.1021/jm0309046
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 6700.0 nM 10.1021/acs.jmedchem.9b01701
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 nan nM 10.1021/jm990554g
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 nan None 10.1016/j.bmc.2012.01.025
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 nan None 10.1016/j.bmcl.2011.02.032
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 nan None 10.1016/j.bmcl.2012.09.111
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 nan None 10.1021/acs.jmedchem.5b01239
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 nan None 10.1021/jm301194c
Homo sapiens Peroxisome proliferator-activated receptor alpha Emax nan None 10.1016/j.bmc.2012.01.025
Homo sapiens Peroxisome proliferator-activated receptor alpha Emax nan None 10.1021/acs.jmedchem.5b01239
Homo sapiens Peroxisome proliferator-activated receptor alpha Fold activation 58.0 % 10.1021/jm0309046
Homo sapiens Peroxisome proliferator-activated receptor alpha IC50 10000.0 nM 10.1021/jm021027r
Homo sapiens Peroxisome proliferator-activated receptor alpha Ki nan nM 10.1016/s0960-894x(99)00603-4
Homo sapiens Peroxisome proliferator-activated receptor alpha Ki nan None 10.1021/acs.jnatprod.2c00791
Homo sapiens Peroxisome proliferator-activated receptor alpha Max 57.8 % 10.1021/jm010964g
Homo sapiens Peroxisome proliferator-activated receptor delta Activity 14.7 % 10.1021/acs.jmedchem.0c01874
Homo sapiens Peroxisome proliferator-activated receptor delta Activity nan None 10.1016/j.bmc.2019.05.028
Homo sapiens Peroxisome proliferator-activated receptor delta Activity nan None 10.1021/jm301194c
Homo sapiens Peroxisome proliferator-activated receptor delta EC50 nan nM 10.1021/jm0309046
Homo sapiens Peroxisome proliferator-activated receptor delta EC50 nan nM 10.1021/jm990554g
Homo sapiens Peroxisome proliferator-activated receptor delta EC50 nan None 10.1021/acs.jmedchem.5b01239
Homo sapiens Peroxisome proliferator-activated receptor delta EC50 nan None 10.1021/jm301194c
Homo sapiens Peroxisome proliferator-activated receptor delta Emax nan None 10.1021/acs.jmedchem.5b01239
Homo sapiens Peroxisome proliferator-activated receptor delta Fold activation 1.0 % 10.1021/jm0309046
Homo sapiens Peroxisome proliferator-activated receptor delta Ki nan nM 10.1016/s0960-894x(99)00603-4
Homo sapiens Peroxisome proliferator-activated receptor delta Ki nan None 10.1021/acs.jnatprod.2c00791
Homo sapiens Peroxisome proliferator-activated receptor delta Max 1.0 % 10.1021/jm010964g
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 350.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 5.5 uM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 6.9 None 10.1016/j.bmcl.2004.11.053
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 71.94 % 10.1016/j.ejmech.2014.09.010
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 100.0 % 10.1016/j.bmc.2010.06.102
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 100.0 % 10.1016/j.bmc.2018.07.005
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 100.0 % 10.1016/j.bmcl.2010.03.008
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 100.0 % 10.1016/j.bmcl.2011.02.032
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 100.0 % 10.1016/j.ejmech.2016.07.072
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 310.0 % 10.1021/acs.jmedchem.7b00398
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 353.0 % 10.1021/acs.jmedchem.7b00398
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity 780.0 nM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1016/j.bmc.2010.09.068
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1016/j.bmcl.2005.01.074
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1016/j.bmcl.2014.05.034
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1016/j.ejmech.2016.11.051
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1021/acs.jmedchem.9b02150
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1021/acsmedchemlett.2c00511
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1021/np400943b
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None 10.1038/nchembio790
Homo sapiens Peroxisome proliferator-activated receptor gamma Alpha max 100.0 % 10.1016/j.ejmech.2020.112258
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 88.0 nM 10.1016/j.bmcl.2010.02.073
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 98.0 nM 10.1016/j.bmc.2018.10.033
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 100.0 nM 10.1021/acs.jnatprod.8b00439
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 140.0 nM 10.1016/j.bmc.2010.06.102
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 200.0 nM 10.1021/acs.jmedchem.5b01239
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 200.0 nM 10.1021/acs.jnatprod.2c00844
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 200.0 nM 10.1021/jm301194c
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 210.0 nM 10.1021/np500605v
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 240.0 nM 10.1016/j.bmc.2018.07.005
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 250.0 nM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 260.0 nM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 300.0 nM 10.1016/j.bmc.2011.08.003
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 300.0 nM 10.1016/j.bmcl.2010.03.008
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 320.0 nM 10.1016/j.ejmech.2016.08.027
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 350.0 nM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 380.0 nM 10.1016/j.ejmech.2016.11.051
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 390.0 nM 10.1016/j.bmcl.2010.11.032
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 390.0 nM 10.1016/j.bmcl.2011.02.032
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 390.0 nM 10.1016/j.ejmech.2019.111969
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 500.0 nM 10.1016/j.ejmech.2016.07.072
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 550.0 nM 10.1021/jm0510880
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 570.0 nM 10.1016/j.bmc.2012.01.025
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 580.0 nM 10.1016/s0960-894x(01)00649-7
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 580.0 nM 10.1021/jm990554g
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 588.84 nM 10.1016/s0960-894x(99)00603-4
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 588.84 nM 10.1021/jm9804127
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 600.0 nM 10.1007/s00044-010-9428-9
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 800.0 nM 10.1016/j.bmcl.2012.09.111
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 900.0 nM 10.1021/acs.jnatprod.2c00844
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 970.0 nM 10.1021/acs.jmedchem.9b01701
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 970.0 nM 10.1021/jm010964g
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 970.0 nM 10.1021/jm0309046
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 1100.0 nM 10.1016/j.bmcl.2017.04.061
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 1280.0 nM 10.1016/j.bmcl.2012.11.088
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 1280.0 nM 10.1021/jm200409s
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 1400.0 nM 10.1016/j.ejmech.2019.111748
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 1600.0 nM 10.1016/j.ejmech.2016.07.072
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 1600.0 nM 10.1016/j.ejmech.2020.112258
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 2053.0 nM 10.1021/acs.jmedchem.8b01200
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 3300.0 nM 10.1021/acs.jnatprod.2c00844
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 3500.0 nM 10.1021/acs.jnatprod.2c00844
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 6700.0 nM 10.1021/acs.jnatprod.2c00791
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 17700.0 nM 10.1021/acsmedchemlett.2c00511
Homo sapiens Peroxisome proliferator-activated receptor gamma Efficacy 100.0 % 10.1016/j.bmcl.2017.04.061
Homo sapiens Peroxisome proliferator-activated receptor gamma Efficacy 100.0 % 10.1021/acs.jmedchem.8b01200
Homo sapiens Peroxisome proliferator-activated receptor gamma Emax 9.15 % 10.1021/acs.jnatprod.8b00439
Homo sapiens Peroxisome proliferator-activated receptor gamma Emax 80.0 % 10.1021/jm200409s
Homo sapiens Peroxisome proliferator-activated receptor gamma Emax 118.0 % 10.1016/j.bmcl.2010.02.073
Homo sapiens Peroxisome proliferator-activated receptor gamma FC 6.0 None 10.1016/j.ejmech.2019.02.034
Homo sapiens Peroxisome proliferator-activated receptor gamma FC 6.2 None 10.1016/j.bmc.2011.08.003
Homo sapiens Peroxisome proliferator-activated receptor gamma FC 6.36 None 10.1021/acs.jnatprod.1c00881
Homo sapiens Peroxisome proliferator-activated receptor gamma FC 6.6 None 10.1021/np500605v
Homo sapiens Peroxisome proliferator-activated receptor gamma FC 7.2 None 10.1021/acs.jnatprod.9b00691
Homo sapiens Peroxisome proliferator-activated receptor gamma FC 7.8 None 10.1016/j.bmcl.2010.11.032
Homo sapiens Peroxisome proliferator-activated receptor gamma FC 43.1 None 10.1016/j.ejmech.2016.02.064
Homo sapiens Peroxisome proliferator-activated receptor gamma Fold activation 91.0 % 10.1021/jm0309046
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 720.0 nM 10.1016/j.bmcl.2015.05.055
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 800.0 nM 10.1016/j.bmcl.2007.05.081
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 855.0 nM 10.1016/j.bmc.2010.09.068
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 1700.0 nM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 1790.0 nM 10.1016/j.bmc.2018.10.033
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 7400.0 nM 10.1021/jm021027r
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 8000.0 nM 10.1016/j.bmcl.2012.02.043
Homo sapiens Peroxisome proliferator-activated receptor gamma IC50 22000.0 nM 10.1016/j.bmcl.2017.04.061
Homo sapiens Peroxisome proliferator-activated receptor gamma Inhibition 67.5 % 10.1016/j.ejmech.2016.07.072
Homo sapiens Peroxisome proliferator-activated receptor gamma Inhibition 82.6 % 10.1016/j.ejmech.2019.07.043
Homo sapiens Peroxisome proliferator-activated receptor gamma Kd 871.0 nM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 62.0 nM 10.1021/acs.jnatprod.8b00635
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 96.0 nM 10.1021/acs.jmedchem.0c01874
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 300.0 nM 10.1021/acs.jnatprod.2c00844
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 300.0 nM 10.1021/acsmedchemlett.2c00511
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 340.0 nM 10.1016/j.bmc.2019.05.028
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 420.0 nM 10.1021/acs.jmedchem.8b01573
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 600.0 nM 10.1021/acs.jnatprod.2c00791
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 630.0 nM 10.1016/s0960-894x(01)00649-7
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 1230.27 nM 10.1016/s0960-894x(99)00603-4
Homo sapiens Peroxisome proliferator-activated receptor gamma Ki 1230.27 nM 10.1021/jm9804127
Homo sapiens Peroxisome proliferator-activated receptor gamma %max 80.0 % 10.1016/j.bmcl.2012.11.088
Homo sapiens Peroxisome proliferator-activated receptor gamma Max 90.8 % 10.1021/jm010964g
Homo sapiens Peroxisome proliferator-activated receptor gamma max activation 100.0 % 10.1016/j.ejmech.2016.11.051
Homo sapiens Peroxisome proliferator-activated receptor gamma RLU 2.1 None 10.1016/j.bmcl.2012.02.043
Homo sapiens Peroxisome proliferator-activated receptor gamma RLU 2.2 None 10.1016/j.bmcl.2012.02.043
Homo sapiens Peroxisome proliferator-activated receptor gamma RLU 2.8 None 10.1016/j.bmcl.2012.02.043
Homo sapiens Peroxisome proliferator-activated receptor gamma T 46.6 degrees C 10.1021/acs.jmedchem.8b01573
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma fCmax 0.029 uM 10.1124/dmd.111.040758
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein-tyrosine phosphatase 1B Activity 51.1 % 10.1016/j.ejmech.2018.12.032
Homo sapiens Protein-tyrosine phosphatase 1B Activity 70.2 % 10.1016/j.ejmech.2018.12.032
Homo sapiens Protein-tyrosine phosphatase 1B Activity 78.9 % 10.1016/j.ejmech.2018.12.032
Homo sapiens Protein-tyrosine phosphatase 1B IC50 220000.0 nM 10.1016/j.bmcl.2009.09.020
Homo sapiens Protein-tyrosine phosphatase 1B IC50 220000.0 nM 10.1016/j.ejmech.2018.04.061
Homo sapiens Protein-tyrosine phosphatase 1B Inhibition 33.8 % 10.1016/j.ejmech.2020.112508
Homo sapiens Protein-tyrosine phosphatase 1B Inhibition 46.0 % 10.1016/j.ejmech.2020.112508
Homo sapiens Protein-tyrosine phosphatase 1B Inhibition 63.5 % 10.1016/j.ejmech.2020.112508
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens SCC-15 Activity 17.33 % 10.1016/j.ejmech.2017.09.071
Homo sapiens SCC-15 Activity 27.52 % 10.1016/j.ejmech.2017.09.071
Homo sapiens SCC-15 Activity 31.42 % 10.1016/j.ejmech.2017.09.071
Homo sapiens SCC-15 Activity 43.03 % 10.1016/j.ejmech.2017.09.071
Homo sapiens SCC-15 Activity nan None 10.1016/j.ejmech.2017.09.071
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin 7 (5-HT7) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 21.9 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 70.0 % 10.1124/dmd.32.3.291
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 5.6 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 65.0 % 10.1124/dmd.32.3.291
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -9.9 % 10.1021/jm300212s
Homo sapiens THP-1 Activity 165.0 pg/ml 10.1016/j.ejmech.2013.06.005
Homo sapiens THP-1 Activity 2588.33 pg/ml 10.1016/j.ejmech.2013.06.005
Homo sapiens THP-1 IC50 18600.0 nM 10.1016/j.ejmech.2013.12.053
Homo sapiens THP-1 IC50 18840.0 nM 10.1016/j.ejmech.2013.06.005
Homo sapiens THP-1 IC50 50000.0 nM 10.1016/j.ejmech.2013.06.005
Homo sapiens THP-1 IC50 2970000.0 nM 10.1016/j.ejmech.2019.02.034
Homo sapiens THP-1 IC50 nan None 10.1016/j.ejmech.2013.12.053
Homo sapiens THP-1 Inhibition nan % 10.1016/j.ejmech.2019.02.034
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 9683.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosine-protein kinase YES Potency 1729.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23109.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Mus musculus 2-oxoglutarate dehydrogenase, mitochondrial Activity nan None 10.1021/jm301204r
Mus musculus 3T3-L1 Activity 5.51 mmol/L 10.1016/j.bmc.2011.03.063
Mus musculus 3T3-L1 Activity 6.75 mmol/L 10.1016/j.bmc.2011.03.063
Mus musculus 3T3-L1 Activity 7.36 mmol/L 10.1016/j.bmc.2011.03.063
Mus musculus 3T3-L1 Activity 8.15 mmol/L 10.1016/j.bmc.2011.03.063
Mus musculus 3T3-L1 Activity 100.0 % 10.1016/s0960-894x(00)00491-1
Mus musculus 3T3-L1 Activity 230.0 mg/dl 10.1016/j.bmcl.2012.04.108
Mus musculus 3T3-L1 Activity nan None 10.1016/j.bmc.2010.03.055
Mus musculus 3T3-L1 Activity nan None 10.1016/j.bmc.2011.03.063
Mus musculus 3T3-L1 EC50 160.0 nM 10.1021/jm970771m
Mus musculus 3T3-L1 FC 1.5 None 10.1016/j.ejmech.2014.09.010
Mus musculus Cardiotrophin-like cytokine factor 1 Activity nan None 10.1021/jm301204r
Mus musculus Chloride transport protein 6 Activity nan None 10.1021/jm301204r
Mus musculus Citrate synthase, mitochondrial FC 5.52 None 10.1021/jm301204r
Mus musculus Cyclic AMP-dependent transcription factor ATF-2 FC 1.64 None 10.1021/jm301204r
Mus musculus Dihydrolipoyl dehydrogenase, mitochondrial Activity nan None 10.1021/jm301204r
Mus musculus Dihydrolipoyl dehydrogenase, mitochondrial FC 1.88 None 10.1021/jm301204r
Mus musculus Dynactin subunit 1 Activity nan None 10.1021/jm301204r
Mus musculus Dystonin Activity nan None 10.1021/jm301204r
Mus musculus Importin-7 Activity nan None 10.1021/jm301204r
Mus musculus Interleukin-12 subunit beta Activity nan None 10.1021/jm301204r
Mus musculus Membrane transport protein XK Activity nan None 10.1021/jm301204r
Mus musculus Multiple PDZ domain protein Activity nan None 10.1021/jm301204r
Mus musculus Mus musculus Activity -36.0 % 10.1016/j.bmcl.2021.128421
Mus musculus Mus musculus Activity 0.2 mg/dl 10.1021/jm400033f
Mus musculus Mus musculus Activity 0.51 mM 10.1016/j.ejmech.2018.02.069
Mus musculus Mus musculus Activity 6.0 % 10.1016/j.bmcl.2021.128421
Mus musculus Mus musculus Activity 7.3 IU 10.1021/jm400033f
Mus musculus Mus musculus Activity 7.89 mM 10.1016/j.ejmech.2018.02.069
Mus musculus Mus musculus Activity 9.58 % 10.1039/C6MD00467A
Mus musculus Mus musculus Activity 15.1 % 10.1039/C6MD00467A
Mus musculus Mus musculus Activity 16.3 % 10.1016/j.bmcl.2015.02.021
Mus musculus Mus musculus Activity 16.3 % 10.1016/j.ejmech.2018.02.069
Mus musculus Mus musculus Activity 17.0 % 10.1016/j.bmcl.2011.02.032
Mus musculus Mus musculus Activity 21.3 IU 10.1021/jm400033f
Mus musculus Mus musculus Activity 21.9 % 10.1016/j.ejmech.2018.02.069
Mus musculus Mus musculus Activity 22.2 mg/dl 10.1021/jm400033f
Mus musculus Mus musculus Activity 23.9 % 10.1039/C6MD00467A
Mus musculus Mus musculus Activity 34.5 % 10.1016/j.ejmech.2018.02.069
Mus musculus Mus musculus Activity 34.8 % 10.1039/C6MD00467A
Mus musculus Mus musculus Activity 37.1 % 10.1016/j.ejmech.2018.02.069
Mus musculus Mus musculus Activity 37.4 % 10.1016/j.ejmech.2018.02.069
Mus musculus Mus musculus Activity 45.3 IU 10.1021/jm400033f
Mus musculus Mus musculus Activity 45.4 % 10.1039/C6MD00467A
Mus musculus Mus musculus Activity 46.2 % 10.1016/j.ejmech.2017.02.031
Mus musculus Mus musculus Activity 46.9 % 10.1016/j.ejmech.2017.02.031
Mus musculus Mus musculus Activity 50.0 % 10.1021/jm900097m
Mus musculus Mus musculus Activity 53.0 % 10.1021/jm900367w
Mus musculus Mus musculus Activity 58.1 % 10.1039/C6MD00467A
Mus musculus Mus musculus Activity 59.1 % 10.1039/C6MD00467A
Mus musculus Mus musculus Activity 65.0 % 10.1021/jm900367w
Mus musculus Mus musculus Activity 74.6 % 10.1021/acs.jnatprod.5b00883
Mus musculus Mus musculus Activity 94.76 mmol/L.min 10.1016/j.bmcl.2022.129081
Mus musculus Mus musculus Activity 124.0 mg/dl 10.1021/jm400033f
Mus musculus Mus musculus Activity 147.3 mg/dl 10.1021/jm400033f
Mus musculus Mus musculus Activity 213.0 ng/ml 10.1016/j.bmcl.2018.12.043
Mus musculus Mus musculus Activity 395.7 IU 10.1021/jm400033f
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2010.11.032
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2013.01.090
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2018.08.036
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2019.06.027
Mus musculus Mus musculus Activity nan None 10.1021/acsmedchemlett.6b00360
Mus musculus Mus musculus Activity nan None 10.1021/jm900097m
Mus musculus Mus musculus Activity nan None 10.1039/C3MD00138E
Mus musculus Mus musculus Activity nan None 10.1039/C6MD00467A
Mus musculus Mus musculus AUC 64161.0 ng.hr.mL-1 10.1021/jm900367w
Mus musculus Mus musculus AUC 73072.25 ng.hr.mL-1 10.1021/jm900097m
Mus musculus Mus musculus Average food intake 6.34 g mouse-1 day-1 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Average sample intake 23.0 mg kg-1 day-1 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Blood glucose 191.0 mg dl-1 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Blood glucose 486.0 mg dl-1 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Body weight 52.5 g 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Body weight 53.6 g 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Body weight 55.1 g 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Body weight 55.8 g 10.1016/j.bmcl.2003.09.052
Mus musculus Mus musculus Decrease in blood glucose 14.0 % 10.1016/s0960-894x(99)00039-6
Mus musculus Mus musculus ED25 4.6 mg kg-1 day-1 10.1021/jm970771m
Mus musculus Mus musculus ED25 6.0 mg/kg/day 10.1016/j.bmc.2019.115263
Mus musculus Mus musculus ED50 2.6 mg.kg-1 10.1021/jm0309046
Mus musculus Mus musculus ED50 2.62 mg.kg-1 10.1021/jm010964g
Mus musculus Mus musculus ED50 12.0 mg.kg-1 10.1021/jm0309046
Mus musculus Mus musculus ED50 15.0 mg.kg-1 10.1021/jm0309046
Mus musculus Mus musculus ED50 15.05 mg.kg-1 10.1021/jm010964g
Mus musculus Mus musculus ED50 19.0 mg kg-1 day-1 10.1021/jm970771m
Mus musculus Mus musculus ED50 26.74 mg.kg-1 10.1021/jm010964g
Mus musculus Mus musculus ED50 27.0 mg.kg-1 10.1021/jm0309046
Mus musculus Mus musculus Efficacy 9.17 % 10.1039/C3MD00138E
Mus musculus Mus musculus Efficacy 11.1 % 10.1039/C3MD00138E
Mus musculus Mus musculus Efficacy 12.6 % 10.1039/C3MD00138E
Mus musculus Mus musculus Efficacy 40.8 % 10.1039/C3MD00138E
Mus musculus Mus musculus Efficacy 46.1 % 10.1039/C3MD00138E
Mus musculus Mus musculus Efficacy 52.9 % 10.1039/C3MD00138E
Mus musculus Mus musculus Efficacy 64.7 % 10.1039/C3MD00138E
Mus musculus Mus musculus Efficacy 70.3 % 10.1039/C3MD00138E
Mus musculus Mus musculus FC 1.37 None 10.1039/C3MD00138E
Mus musculus Mus musculus Inhibition 10.0 % 10.1016/j.bmcl.2011.02.032
Mus musculus Mus musculus Inhibition 25.0 % 10.1016/j.bmcl.2015.02.021
Mus musculus Mus musculus Inhibition 30.0 % 10.1016/j.bmcl.2015.02.021
Mus musculus Mus musculus Inhibition 30.6 % 10.1016/j.bmcl.2015.02.021
Mus musculus Mus musculus Inhibition 32.3 % 10.1021/acs.jnatprod.5b00883
Mus musculus Mus musculus Inhibition 46.0 % 10.1016/j.bmcl.2011.02.032
Mus musculus Mus musculus Inhibition 69.0 % 10.1016/j.bmcl.2011.02.032
Mus musculus Mus musculus Inhibition nan % 10.1016/j.bmcl.2015.02.021
Mus musculus Mus musculus Max reduction 21.0 % 10.1021/jm010964g
Mus musculus Mus musculus Max reduction 21.0 % 10.1021/jm0309046
Mus musculus Mus musculus Max reduction 39.0 % 10.1021/jm010964g
Mus musculus Mus musculus Max reduction 39.0 % 10.1021/jm0309046
Mus musculus Mus musculus Max reduction 53.0 % 10.1021/jm010964g
Mus musculus Mus musculus Max reduction 53.0 % 10.1021/jm0309046
Mus musculus Mus musculus Max reduction 54.0 % 10.1021/jm010964g
Mus musculus Mus musculus Max reduction 54.0 % 10.1021/jm0309046
Mus musculus Mus musculus MED 200.0 uM.kg/diet 10.1016/S0960-894X(01)80325-5
Mus musculus Mus musculus MED 300.0 uM kg-1 10.1021/jm950395a
Mus musculus Mus musculus Rate of decrease 41.0 % 10.1016/s0960-894x(99)00039-6
Mus musculus Mus musculus Rate of decrease 43.0 % 10.1016/s0960-894x(99)00039-6
Mus musculus Mus musculus Rate of decrease 64.0 % 10.1016/s0960-894x(99)00039-6
Mus musculus Mus musculus Rate of decrease 75.0 % 10.1016/s0960-894x(99)00039-6
Mus musculus Mus musculus Rate of decrease 85.0 % 10.1016/s0960-894x(99)00039-6
Mus musculus Mus musculus Rate of decrease 99.0 % 10.1016/s0960-894x(99)00039-6
Mus musculus Mus musculus Reduction 35.0 % 10.1021/jm00049a017
Mus musculus Mus musculus Reduction 62.0 % 10.1021/jm00049a017
Mus musculus Mus musculus Reduction 63.0 % 10.1021/jm00049a017
Mus musculus Mus musculus Reduction nan None 10.1021/jm00049a017
Mus musculus Mus musculus Survival 8.0 % 10.1016/j.ejmech.2016.06.017
Mus musculus Mus musculus T/C 0.49 None 10.1021/jm9605694
Mus musculus Mus musculus T/C 0.56 None 10.1016/j.bmc.2018.10.033
Mus musculus Neurofibromin Activity nan None 10.1021/jm301204r
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Norrin Activity nan None 10.1021/jm301204r
Mus musculus Peroxisome proliferator-activated receptor alpha EC50 nan nM 10.1021/jm950395a
Mus musculus Peroxisome proliferator-activated receptor alpha EC50 nan nM 10.1021/jm990554g
Mus musculus Peroxisome proliferator-activated receptor alpha IC50 1150.0 nM 10.1021/acs.jmedchem.9b01701
Mus musculus Peroxisome proliferator-activated receptor delta EC50 nan nM 10.1021/jm950395a
Mus musculus Peroxisome proliferator-activated receptor delta EC50 nan nM 10.1021/jm990554g
Mus musculus Peroxisome proliferator-activated receptor gamma Activity nan None 10.1016/j.bmcl.2018.12.043
Mus musculus Peroxisome proliferator-activated receptor gamma Displacement 90.0 % 10.1021/jm950395a
Mus musculus Peroxisome proliferator-activated receptor gamma EC50 550.0 nM 10.1021/jm990554g
Mus musculus Peroxisome proliferator-activated receptor gamma EC50 690.0 nM 10.1021/jm950395a
Mus musculus Peroxisome proliferator-activated receptor gamma FC 4.0 None 10.1016/j.ejmech.2016.08.027
Mus musculus Peroxisome proliferator-activated receptor gamma IC50 700.0 nM 10.1016/j.bmcl.2008.08.028
Mus musculus Protein kinase C and casein kinase substrate in neurons protein 2 Activity nan None 10.1021/jm301204r
Mus musculus Serine/threonine-protein kinase MAK Activity nan None 10.1021/jm301204r
Mus musculus Serine/threonine-protein kinase WNK1 FC 3.24 None 10.1021/jm301204r
Mus musculus Trace amine-associated receptor 7b Activity nan None 10.1021/jm301204r
Mus musculus Transcription factor SOX-5 Activity nan None 10.1021/jm301204r
Mus musculus Tyrosine-protein kinase transmembrane receptor ROR1 Activity nan None 10.1021/jm301204r
Mus musculus Voltage-dependent L-type calcium channel subunit alpha-1F Activity nan None 10.1021/jm301204r
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Rattus norvegicus 26S proteasome non-ATPase regulatory subunit 1 Activity nan None 10.1021/jm301204r
Rattus norvegicus Afadin- and alpha-actinin-binding protein Activity nan None 10.1021/jm301204r
Rattus norvegicus Aldose reductase IC50 13200.0 nM None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Aspartate aminotransferase mitochondrial Activity nan None 10.1021/jm301204r
Rattus norvegicus ATP synthase subunit alpha, mitochondrial Activity nan None 10.1021/jm301204r
Rattus norvegicus ATP synthase subunit beta, mitochondrial Activity nan None 10.1021/jm301204r
Rattus norvegicus Bile salt export pump IC50 2000.0 nM 10.1124/dmd.111.040758
Rattus norvegicus Carnitine palmitoyltransferase 2 IC50 100000.0 nM 10.6019/CHEMBL3431459
Rattus norvegicus CDGSH iron-sulfur domain-containing protein 1 IC50 1000.0 nM 10.1016/j.bmcl.2009.12.088
Rattus norvegicus Cortex Activity nan None 10.1021/acsmedchemlett.8b00574
Rattus norvegicus Creatine kinase B-type Activity nan None 10.1021/jm301204r
Rattus norvegicus Creatine kinase M-type FC 6.16 None 10.1021/jm301204r
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glyceraldehyde-3-phosphate dehydrogenase Activity nan None 10.1021/jm301204r
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Hemopexin Activity nan None 10.1021/jm301204r
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Kalirin Activity nan None 10.1021/jm301204r
Rattus norvegicus Liver Activity nan None 10.1021/acsmedchemlett.8b00574
Rattus norvegicus Liver IC50 100.0 nM 10.1002/hep.27206
Rattus norvegicus L-lactate dehydrogenase B chain Activity nan None 10.1021/jm301204r
Rattus norvegicus L-lactate dehydrogenase B chain FC 2.26 None 10.1021/jm301204r
Rattus norvegicus Long-chain specific acyl-CoA dehydrogenase, mitochondrial Activity nan None 10.1021/jm301204r
Rattus norvegicus Long-chain specific acyl-CoA dehydrogenase, mitochondrial FC 5.78 None 10.1021/jm301204r
Rattus norvegicus Monoamine oxidase A Inhibition nan % 10.1021/ml200196p
Rattus norvegicus Monoamine oxidase B Ki 2100.0 nM 10.1021/ml200196p
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-10 subunit Activity nan None 10.1021/jm301204r
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Peroxisome proliferator-activated receptor alpha Fold activation 4.0 % 10.1021/jm0309046
Rattus norvegicus Peroxisome proliferator-activated receptor gamma Activity nan None 10.1016/j.ejmech.2019.02.034
Rattus norvegicus Peroxisome proliferator-activated receptor gamma IC50 700.0 nM 10.1016/j.bmcl.2008.04.072
Rattus norvegicus Phosphoglycerate kinase 1 Activity nan None 10.1021/jm301204r
Rattus norvegicus Protein-tyrosine kinase 2-beta Activity nan None 10.1021/jm301204r
Rattus norvegicus PX domain-containing protein kinase-like protein Activity nan None 10.1021/jm301204r
Rattus norvegicus Ras GTPase-activating protein SynGAP Activity nan None 10.1021/jm301204r
Rattus norvegicus Rattus norvegicus Activity 30.5 ug ml-1 10.1021/jm200409s
Rattus norvegicus Rattus norvegicus Activity 35.25 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 40.96 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 41.6 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 45.89 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 47.02 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 47.25 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 64.59 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 75.43 % 10.1016/j.ejmech.2012.04.015
Rattus norvegicus Rattus norvegicus Activity 115.0 mg/dl 10.1016/j.ejmech.2017.02.031
Rattus norvegicus Rattus norvegicus Activity 118.0 mg/dl 10.1021/jm200409s
Rattus norvegicus Rattus norvegicus Activity 132.0 mg/dl 10.1016/j.ejmech.2014.09.010
Rattus norvegicus Rattus norvegicus Activity 269.0 g 10.1021/jm200409s
Rattus norvegicus Rattus norvegicus Activity 316.0 mg/dl 10.1021/jm200409s
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2014.05.034
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2014.09.010
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm200409s
Rattus norvegicus Rattus norvegicus ALB 39300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 45500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 46300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 266.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 305.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 338.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 346.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 406.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 427.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 504.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 537.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 36.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 58.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 60.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 71.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 81.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 85.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 71.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 80.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 87.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 92.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 94.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 96.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 97.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 102.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 86.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 113.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 130.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 135.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 566.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 583.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 626.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 646.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 670.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 703.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 758.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 223.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 226.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 248.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 311.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 345.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 366.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 464.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 625.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30170000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ED25 0.5 mg/kg/day 10.1016/j.bmc.2019.115263
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 22.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 26.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 36.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 37.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 196.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1310.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1370.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1406.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1425.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1478.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1503.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1556.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 29.23 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 30.03 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 31.27 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.62 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.97 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 112000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 115000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 130000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 131700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 139300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 144700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 98.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 107.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 111.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 114.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 125.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 136.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 224.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 542.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8411.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8937.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10004.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11213.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11883.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12765.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13366.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15172.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 84.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.93 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.95 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.2 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.65 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.3 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 26.4 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 27.17 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 378300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 382700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 383000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 387700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 391800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 398300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 413700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.47 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.95 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.17 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.28 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.8 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.23 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.73 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 43.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 92.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 95.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 131.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 138.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 141.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 155.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 169.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 14.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 829.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 960.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1128.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1150.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1161.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1182.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1184.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1396.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 105.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 106.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 107.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 109.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 122.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 962000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1023330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1035330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1057000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1095330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1174000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1242330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1282000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.14 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.41 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.48 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.99 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.21 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.64 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 53300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 54700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 65300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 66500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4680000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4760000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4930000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5340000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5500000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5510000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5610000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.67 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.57 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.48 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.77 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 5.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9900.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10230.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12370.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13730.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14900.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Sodium-dependent multivitamin transporter Activity nan None 10.1021/jm301204r
Rattus norvegicus Trace amine-associated receptor 7b Activity nan None 10.1021/jm301204r
Rattus norvegicus Triosephosphate isomerase FC 6.46 None 10.1021/jm301204r
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 10.3 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 AUC 272.2 None 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.08808 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 676.08 nM 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.14 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.9499 None 10.1101/2020.04.03.023846
None ADMET Activity 15.5 g 10.1016/j.bmcl.2004.11.053
None ADMET Activity 32.3 g 10.1016/j.bmcl.2018.12.043
None ADMET Activity 41.0 % 10.1016/j.bmc.2019.115122
None ADMET Activity 45.0 mg 10.1021/acs.jmedchem.0c00524
None ADMET Activity 96.6 g 10.1016/j.bmcl.2004.11.053
None ADMET Activity nan None 10.1016/j.bmc.2013.02.003
None ADMET Activity nan None 10.1016/j.bmcl.2019.06.027
None ADMET Activity nan None 10.1021/acs.jmedchem.8b00610
None ADMET AUC 1753075.0 ng min 10.1021/jm010964g
None ADMET AUC ED50 12.09 mg kg-1 10.1021/jm010964g
None ADMET AUC Ratio 0.869 None 10.1038/s41586-020-2286-9
None ADMET CL 3.6e-05 mL.min-1.g-1 10.1124/dmd.111.039180
None ADMET CL 0.036 uL/min 10.1124/dmd.111.039180
None ADMET CL 1.4 mL.min-1.kg-1 10.1021/jm010964g
None ADMET Cmax 13087.39 nM 10.1021/jm010964g
None ADMET Drug metabolism 4.0 pmol 10.1021/acs.jmedchem.0c01917
None ADMET Drug metabolism 12.0 pmol 10.1021/acs.jmedchem.0c01917
None ADMET Drug metabolism 594.0 pmol 10.1021/acs.jmedchem.0c01917
None ADMET Drug metabolism 599.0 pmol 10.1021/acs.jmedchem.0c01917
None ADMET Drug metabolism 3446.0 pmol 10.1021/acs.jmedchem.0c01917
None ADMET Drug metabolism 3458.0 pmol 10.1021/acs.jmedchem.0c01917
None ADMET F 112.0 % 10.1021/jm010964g
None ADMET Glucose level 174.0 mg dl-1 10.1016/j.bmcl.2004.11.053
None ADMET Glucose level 432.0 mg dl-1 10.1016/j.bmcl.2004.11.053
None ADMET T1/2 3.8 hr 10.1021/jm010964g
None ADMET Triglyceride level 73.0 mg dl-1 10.1016/j.bmcl.2004.11.053
None ADMET Triglyceride level 109.0 mg dl-1 10.1016/j.bmcl.2004.11.053
None ADMET Vdss 0.22 L.kg-1 10.1021/jm010964g
None Cerebellar granule neurone Activity nan None 10.1021/acs.jmedchem.8b00610
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 3.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LTKB_BD DILI severity score 3.0 None 10.1016/j.drudis.2011.05.007
None Molecular identity unknown Activity nan None 10.1021/acs.jnatprod.6b00227
None NON-PROTEIN TARGET Activity nan None 10.1021/acsmedchemlett.6b00360
None NON-PROTEIN TARGET GI 55.8 % 10.1016/j.ejmech.2016.08.027
None NON-PROTEIN TARGET GI nan None 10.1016/j.ejmech.2016.08.027
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.4 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 3.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2019.111808
None NON-PROTEIN TARGET Inhibition 30.2 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition 41.4 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition 62.4 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition nan % 10.1016/j.ejmech.2019.111808
None NON-PROTEIN TARGET Inhibition nan % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Potency 1.5 nM None
None NON-PROTEIN TARGET Potency 3.0 nM None
None NON-PROTEIN TARGET Potency 13.3 nM None
None NON-PROTEIN TARGET Potency 211.2 nM None
None NON-PROTEIN TARGET Potency 943.3 nM None
None NON-PROTEIN TARGET Potency 14950.2 nM None
None NON-PROTEIN TARGET Potency 23694.5 nM None
None No relevant target IC50 44100.0 nM 10.1016/j.ejmech.2019.111808
None No relevant target LogD 4.0 None 10.6019/CHEMBL3431459
None No relevant target LogD7.4 2.8 None 10.6019/CHEMBL3301361
None No relevant target LogP 3.17 None 10.1016/j.bmc.2015.03.071
None No relevant target Permeability 74.9 nm s-1 10.6019/CHEMBL3431459
None No relevant target pKa 13.74 None 10.1124/dmd.112.050278
None No relevant target solubility nan None 10.1021/acs.jmedchem.5b01239
None No relevant target Solubility 1.0 ug.mL-1 10.6019/CHEMBL3431459
None No relevant target Solubility 2000.0 nM 10.6019/CHEMBL3301361
None Unchecked Activity 10.0 % 10.1016/s0960-894x(00)00491-1
None Unchecked Activity 100.0 % 10.1016/j.bmc.2010.06.102
None Unchecked Activity nan None 10.1016/j.bmc.2013.02.003
None Unchecked Activity nan None 10.1016/j.bmc.2019.05.028
None Unchecked Activity nan None 10.1016/j.ejmech.2019.02.034
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112258
None Unchecked EC50 340.0 nM 10.1021/acs.jmedchem.0c01874
None Unchecked EC50 350.0 nM 10.1021/acs.jnatprod.8b00635
None Unchecked EC50 500.0 nM 10.1016/j.bmc.2019.115226
None Unchecked EC50 500.0 nM 10.1021/acsmedchemlett.2c00511
None Unchecked GI50 nan None 10.1016/j.bmcl.2020.127561
None Unchecked Hepatotoxicity (acute) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 1200.0 nM 10.1021/acs.jmedchem.9b01701
None Unchecked IC50 86922.0 nM None
None Unchecked IC50 nan None None
None Unchecked Ki 22055.0 nM None
None Unchecked Ki nan None None
None Unchecked Potency 3.0 nM None
None Unchecked Potency 66.2 nM None
None Unchecked Potency 2093.1 nM None
None Unchecked Potency 4685.9 nM None
None Unchecked Potency 16626.1 nM None
None Unchecked Potency 16771.6 nM None
None Unchecked Potency 18654.8 nM None
None Unchecked Potency 20931.0 nM None
None Unchecked Potency 23485.0 nM None
None Unchecked Potency 26350.6 nM None
None Unchecked Potency 29565.9 nM None
None Unchecked Potency 37221.2 nM None
None Unchecked Potency 104903.6 nM None
None Unchecked Ratio 0.019 None 10.1093/toxsci/kft176
None Unchecked Ratio 2.338 None 10.1093/toxsci/kft176

Metabolism Information