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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK323071

Synonym: None

IUPAC Name: 2-(2-amino-3-methoxyphenyl)chromen-4-one

Structure

SMILES: COC1=CC=CC(C2=CC(=O)C3=CC=CC=C3O2)=C1N

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InChI: InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

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InChIKey: QFWCYNPOPKQOKV-UHFFFAOYSA-N

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Reference

PubChem CID: 4713

CAS: 167869-21-8

NPASS: NPC480173

Properties Information

Molecule Weight: 267.284

TPSA？: 65.46

MolLogP？: 3.0508000000000006

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 12589.3 nM None
Caenorhabditis elegans Caenorhabditis elegans Activity 5.3 % 10.1038/nchembio.282
Caenorhabditis elegans Caenorhabditis elegans Activity nan None 10.1038/nchembio.282
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 6309.6 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 12589.3 nM None
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens 786-0 GI50 70957.78 nM None
Homo sapiens 78 kDa glucose-regulated protein Potency 16481.6 nM None
Homo sapiens A549 GI50 91833.26 nM None
Homo sapiens ACHN GI50 100000.0 nM None
Homo sapiens Activin receptor type-1B Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 3548.1 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 22387.2 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 37650.5 nM None
Homo sapiens ALK tyrosine kinase receptor Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Arachidonate 15-lipoxygenase Potency 15848.9 nM None
Homo sapiens Ataxin-2 Potency 1000.0 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 1834.9 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 2908.1 nM None
Homo sapiens Beta-glucocerebrosidase Potency 31622.8 nM None
Homo sapiens BJ Survival 78.0 % 10.1038/nature05859
Homo sapiens Bloom syndrome protein Potency 63095.7 nM None
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens BT-549 GI50 100000.0 nM None
Homo sapiens Caco-2 NT nan None 10.1021/jm0102856
Homo sapiens CAKI-1 GI50 100000.0 nM None
Homo sapiens CaM kinase I alpha Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase beta Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I delta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase II Inhibition 87.0 % 10.1042/0264-6021:3510095
Homo sapiens Casein kinase II Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CCRF-CEM GI50 100000.0 nM None
Homo sapiens CDK3/cyclin E Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Cellular tumor antigen p53 Potency 5011.9 nM None
Homo sapiens Cellular tumor antigen p53 Potency 7943.3 nM None
Homo sapiens Cerebroside-sulfatase Potency 13.5 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Chromobox protein homolog 1 Potency 26679.5 nM None
Homo sapiens c-Jun N-terminal kinase 1 Inhibition 111.0 % 10.1042/0264-6021:3510095
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens COLO 205 GI50 9931.16 nM None
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclooxygenase-1 IC50 1000.0 nM 10.1021/jm020427b
Homo sapiens Cytochrome P450 1A2 AC50 199.53 nM None
Homo sapiens Cytochrome P450 2C19 AC50 6309.57 nM None
Homo sapiens Cytochrome P450 2C19 Potency 6309.6 nM None
Homo sapiens Cytochrome P450 2C19 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 2C9 AC50 31622.78 nM None
Homo sapiens Cytochrome P450 2C9 Potency 31622.8 nM None
Homo sapiens Cytochrome P450 2D6 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 2D6 Potency 7943.3 nM None
Homo sapiens Cytochrome P450 3A4 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 3A4 Potency 7943.3 nM None
Homo sapiens Death-associated protein kinase 1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 39810.7 nM None
Homo sapiens DU-145 GI50 100000.0 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 FC 100.0 None 10.1038/nchembio.282
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 IC50 2000.0 nM 10.1021/jm020427b
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 IC50 4000.0 nM 10.1039/C2MD20181J
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 IC50 10000.0 nM 10.1021/jm0102856
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 FC 100.0 None 10.1038/nchembio.282
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 IC50 50000.0 nM 10.1039/C2MD20181J
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 138.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase; MEK1/2 Inhibition nan % 10.1021/acs.jnatprod.9b00646
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens EKVX GI50 16180.8 nM None
Homo sapiens Ephrin type-A receptor 1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 143.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 128.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Geminin Potency 15848.9 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 101.0 % 10.1042/0264-6021:3510095
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens HCC 2998 GI50 28183.83 nM None
Homo sapiens HCT-116 GI50 51999.6 nM None
Homo sapiens HCT-15 GI50 100000.0 nM None
Homo sapiens HEK293 Potency 73.0 nM None
Homo sapiens HEK293 Potency 1995.3 nM None
Homo sapiens Hepatocyte growth factor receptor Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Histone deacetylase 6 IC50 1837.0 nM 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 89.98 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 97.37 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 97.69 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 10000.0 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 37685.8 nM None
Homo sapiens HL-60 GI50 6760.83 nM None
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens HOP-62 GI50 18323.14 nM None
Homo sapiens HOP-92 GI50 83368.12 nM None
Homo sapiens Hs-578T GI50 71944.9 nM None
Homo sapiens HT-1080 Survival 26.0 % 10.1038/nature05859
Homo sapiens HT-29 GI50 12793.81 nM None
Homo sapiens HT-29 IC50 4000.0 nM 10.1016/j.ejmech.2014.07.018
Homo sapiens IGROV-1 GI50 87498.38 nM None
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 127.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens K562 GI50 75335.56 nM None
Homo sapiens KM12 GI50 100000.0 nM None
Homo sapiens LIM domain kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens LoVo NT nan None 10.1021/jm0102856
Homo sapiens LOX IMVI GI50 100000.0 nM None
Homo sapiens M14 GI50 5559.04 nM None
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Malme-3M GI50 3622.43 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 95.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Inhibition 108.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Activity 10.0 uM 10.1021/jm049715t
Homo sapiens MAP kinase ERK1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 IC50 2800.0 nM 10.1021/jm0102856
Homo sapiens MAP kinase ERK2 Inhibition 85.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase ERK2 Potency 3162.3 nM None
Homo sapiens MAP kinase ERK2 Potency 3981.1 nM None
Homo sapiens MAP kinase ERK2 Potency 5011.9 nM None
Homo sapiens MAP kinase ERK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Inhibition 85.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 alpha Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Inhibition 95.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 beta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase p38 delta Inhibition 94.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 delta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Inhibition 96.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 gamma Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens MCF7 GI50 100000.0 nM None
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.ejmech.2012.07.041
Homo sapiens MDA-MB-231 GI50 26915.35 nM None
Homo sapiens MDA-MB-435 GI50 23014.42 nM None
Homo sapiens MDA-N GI50 24434.31 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens Microtubule-associated protein tau Potency 14125.4 nM None
Homo sapiens Microtubule-associated protein tau Potency 15848.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 25118.9 nM None
Homo sapiens Microtubule-associated protein tau Potency 39810.7 nM None
Homo sapiens Misshapen-like kinase 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase; ERK1/ERK2 Inhibition nan % 10.1021/np300887d
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens MOLT-4 GI50 100000.0 nM None
Homo sapiens Muscleblind-like protein 1 Potency 12589.3 nM None
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens NCI/ADR-RES GI50 33036.95 nM None
Homo sapiens NCI-H226 GI50 62950.62 nM None
Homo sapiens NCI-H23 GI50 72945.75 nM None
Homo sapiens NCI-H322M GI50 81283.05 nM None
Homo sapiens NCI-H460 GI50 59020.11 nM None
Homo sapiens NCI-H522 GI50 27925.44 nM None
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Niemann-Pick C1 protein Potency 2310.9 nM None
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 1458.1 nM None
Homo sapiens OVCAR-3 GI50 100000.0 nM None
Homo sapiens OVCAR-4 GI50 84333.48 nM None
Homo sapiens OVCAR-5 GI50 90991.33 nM None
Homo sapiens OVCAR-8 GI50 52966.34 nM None
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens PC-3 FC 0.901 None 10.1038/nchembio790
Homo sapiens PC-3 GI50 23550.49 nM None
Homo sapiens PDZ-binding kinase Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Peripheral myelin protein 22 Potency 1694.4 nM None
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Inhibition 93.0 % 10.1042/0264-6021:3510095
Homo sapiens Protein kinase C alpha Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Pyruvate dehydrogenase kinase isoform 1 Inhibition 86.0 % 10.1042/0264-6021:3510095
Homo sapiens Pyruvate kinase isozymes M1/M2 Potency 15848.9 nM None
Homo sapiens Ras-related protein Rab-9A Potency 2059.6 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Regulator of G-protein signaling 4 Potency 21192.3 nM None
Homo sapiens Rho-associated protein kinase 1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Inhibition 100.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 86.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 133.0 % 10.1042/bj20121418
Homo sapiens RPMI-8226 GI50 76559.66 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 17782.8 nM None
Homo sapiens RXF 393 GI50 44977.99 nM None
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 82.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 99.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change -0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change 0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) IC50 2800.0 nM 10.1021/jm0102856
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 90.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 140.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens SF-268 GI50 61235.04 nM None
Homo sapiens SF-295 GI50 66069.34 nM None
Homo sapiens SF-539 GI50 63533.09 nM None
Homo sapiens SK-MEL-2 GI50 27352.69 nM None
Homo sapiens SK-MEL-28 GI50 10139.11 nM None
Homo sapiens SK-MEL-5 GI50 42756.29 nM None
Homo sapiens SK-OV-3 GI50 14996.85 nM None
Homo sapiens SN12C GI50 100000.0 nM None
Homo sapiens SNB-19 GI50 51880.0 nM None
Homo sapiens SNB-75 GI50 51641.64 nM None
Homo sapiens SR GI50 100000.0 nM None
Homo sapiens Stem cell growth factor receptor Inhibition nan % None
Homo sapiens Stem cell growth factor receptor Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Survival motor neuron protein Potency 7943.3 nM None
Homo sapiens Survival motor neuron protein Potency 8912.5 nM None
Homo sapiens Survival motor neuron protein Potency 11220.2 nM None
Homo sapiens SW-620 GI50 15523.87 nM None
Homo sapiens T47D GI50 11912.42 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Thrombopoietin Potency 398.1 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 6309.6 nM None
Homo sapiens TK-10 GI50 100000.0 nM None
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Inhibition 85.0 % 10.1042/0264-6021:3510095
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 137.0 % 10.1042/bj20121418
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 3349.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29855.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 32642.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 35481.3 nM None
Homo sapiens U-251 GI50 100000.0 nM None
Homo sapiens UACC-257 GI50 36643.76 nM None
Homo sapiens UACC-62 GI50 5272.3 nM None
Homo sapiens UO-31 GI50 36307.81 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 95.0 % 10.1042/bj20121418
Influenza A virus Nonstructural protein 1 Potency 5011.9 nM None
Leishmania mexicana Pyruvate kinase Potency 12589.3 nM None
Mus musculus Lymphocyte antigen 96 Inhibition nan % 10.1021/acs.jmedchem.5b01574
Mus musculus Mitogen-activated protein kinase 1 and 3 (ERK2 and ERK1) Inhibition nan % 10.1016/j.bmc.2022.116811
Mus musculus Nuclear receptor ROR-gamma Potency 31622.8 nM None
Mus musculus RAW264.7 Inhibition -2.4 % 10.1016/j.bmc.2012.06.031
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmcl.2013.05.058
Photinus pyralis Luciferin 4-monooxygenase IC50 6200.0 nM 10.1021/jm701302v
Photinus pyralis Luciferin 4-monooxygenase IC50 6400.0 nM 10.1021/jm701302v
Photinus pyralis Luciferin 4-monooxygenase IC50 11000.0 nM 10.1021/jm701302v
Photinus pyralis Luciferin 4-monooxygenase IC50 60000.0 nM 10.1021/jm701302v
Photinus pyralis Luciferin 4-monooxygenase IC50 100000.0 nM 10.1021/jm701302v
Photinus pyralis Luciferin 4-monooxygenase Potency 12589.3 nM None
Photinus pyralis Luciferin 4-monooxygenase Potency 25118.9 nM None
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum Potency 928.5 nM None
Plasmodium falciparum Plasmodium falciparum Potency 1311.5 nM None
Rattus norvegicus Dual specificity mitogen-activated protein kinase kinase MEK1/2 IC50 4200.0 nM 10.1016/j.ejmech.2014.07.018
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 3162.3 nM None
Rattus norvegicus Nuclear factor erythroid 2-related factor 2 Activity nan None 10.1016/j.bmc.2011.01.059
Rattus norvegicus Rho-associated protein kinase 2 Inhibition 80.0 % 10.1042/0264-6021:3510095
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 562.3 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 18356.4 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 8.098 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 24.97 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.23 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.22 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.73 % 10.21203/rs.3.rs-23951/v1
Trypanosoma brucei 6-phospho-1-fructokinase Potency 37.9 nM None
None NON-PROTEIN TARGET Potency 2.1 nM None
None NON-PROTEIN TARGET Potency 2111.8 nM None
None NON-PROTEIN TARGET Potency 7943.3 nM None
None NON-PROTEIN TARGET Potency 10000.0 nM None
None NON-PROTEIN TARGET Potency 11220.2 nM None
None NON-PROTEIN TARGET Potency 11875.4 nM None
None NON-PROTEIN TARGET Potency 12589.3 nM None
None NON-PROTEIN TARGET Potency 13324.4 nM None
None Unchecked Activity nan None 10.1021/jm701302v
None Unchecked IC50 2000.0 nM 10.1016/j.ejmech.2014.07.018
None Unchecked IC50 2000.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 400000.0 nM 10.1021/jm020427b
None Unchecked Inhibition 87.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 89.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 93.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 97.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 106.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Potency 1000.0 nM None
None Unchecked Potency 1636.0 nM None
None Unchecked Potency 1995.3 nM None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 4609.0 nM None
None Unchecked Potency 7079.5 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Ratio 0.92 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.01 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.12 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.18 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.2 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.23 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.3 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.32 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.53 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.61 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.69 None 10.1016/j.bmc.2010.01.046
None Unchecked Ratio 1.79 None 10.1016/j.bmc.2010.01.046

Metabolism Information