| Bacillus subtilis |
4'-phosphopantetheinyl transferase ffp |
Potency |
2238.7 |
nM |
None |
| Bacillus subtilis |
4'-phosphopantetheinyl transferase ffp |
Potency |
2818.4 |
nM |
None |
| Giardia intestinalis |
Putative fructose-1,6-bisphosphate aldolase |
Potency |
15811.4 |
nM |
None |
| Homo sapiens |
3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
78 kDa glucose-regulated protein |
Potency |
2930.9 |
nM |
None |
| Homo sapiens |
A549 |
GI50 |
nan |
None |
10.1016/j.bmc.2013.11.018 |
| Homo sapiens |
Activin receptor type-1B |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Activin receptor type-1B |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Aldehyde dehydrogenase 1A1 |
Potency |
56.2 |
nM |
None |
| Homo sapiens |
Aldehyde dehydrogenase 1A1 |
Potency |
63.1 |
nM |
None |
| Homo sapiens |
ALK tyrosine kinase receptor |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
ALK tyrosine kinase receptor |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Alpha-synuclein |
Potency |
11582.1 |
nM |
None |
| Homo sapiens |
AMP-activated protein kinase, AMPK |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase, AMPK |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Amyloid-beta A4 protein |
Potency |
2310.9 |
nM |
None |
| Homo sapiens |
Ataxin-2 |
Potency |
10000.0 |
nM |
None |
| Homo sapiens |
ATPase family AAA domain-containing protein 5 |
Potency |
20587.8 |
nM |
None |
| Homo sapiens |
ATPase family AAA domain-containing protein 5 |
Potency |
29081.0 |
nM |
None |
| Homo sapiens |
BGC-823 |
Inhibition |
nan |
% |
10.1016/j.ejmech.2017.08.022 |
| Homo sapiens |
BR serine/threonine-protein kinase 1 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 1 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Residual Activity |
113.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I alpha |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I alpha |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I delta |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I delta |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II beta |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II beta |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II delta |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II delta |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II gamma |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II gamma |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase IV |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase IV |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I delta |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I delta |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 1 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 1 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 2 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I isoform gamma-3 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I isoform gamma-3 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK3/cyclin E |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK3/cyclin E |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK6/cyclin D3 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK6/cyclin D3 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK9/cyclin T1 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK9/cyclin T1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Chromobox protein homolog 1 |
Potency |
39810.7 |
nM |
None |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 1 |
Activity |
nan |
None |
10.1038/nchembio790 |
| Homo sapiens |
Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
124.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 1 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 1 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 2 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 2 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 3 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 3 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Discoidin domain-containing receptor 2 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Discoidin domain-containing receptor 2 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dopamine D1 receptor |
Potency |
12589.3 |
nM |
None |
| Homo sapiens |
DU-145 |
GI50 |
nan |
None |
10.1016/j.bmc.2013.11.018 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
124.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK3 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 1 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 1 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Residual Activity |
122.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Residual Activity |
126.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 3 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 3 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 3 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Focal adhesion kinase 1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Focal adhesion kinase 1 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Gasdermin-D |
Inhibition |
50.0 |
% |
10.1039/C9MD00059C |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 beta |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 beta |
Residual Activity |
121.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 5 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 5 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 6 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 6 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 7 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 7 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
HEK293 |
IC50 |
3800.0 |
nM |
10.1021/np4006635 |
| Homo sapiens |
HEK293 |
Potency |
2310.0 |
nM |
None |
| Homo sapiens |
Hepatocyte growth factor receptor |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Hepatocyte growth factor receptor |
Residual Activity |
123.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Histone acetyltransferase GCN5 |
Potency |
17782.8 |
nM |
None |
| Homo sapiens |
Histone acetyltransferase GCN5 |
Potency |
22387.2 |
nM |
None |
| Homo sapiens |
Histone acetyltransferase GCN5 |
Potency |
31622.8 |
nM |
None |
| Homo sapiens |
Histone deacetylase 6 |
Inhibition |
8.74 |
% |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Histone deacetylase 6 |
Inhibition |
24.05 |
% |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
1122.0 |
nM |
None |
| Homo sapiens |
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
Potency |
1584.9 |
nM |
None |
| Homo sapiens |
Homeodomain-interacting protein kinase 1 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 3 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
HUVEC |
Inhibition |
12.7 |
% |
10.1021/np400834c |
| Homo sapiens |
HUVEC |
Inhibition |
23.7 |
% |
10.1021/np400834c |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor-related protein |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor-related protein |
Residual Activity |
119.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
KB |
GI50 |
nan |
None |
10.1016/j.bmc.2013.11.018 |
| Homo sapiens |
LIM domain kinase 1 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage-stimulating protein receptor |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage-stimulating protein receptor |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 2 |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 3 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 3 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 5 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 5 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK1 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK1 |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK2 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK2 |
Residual Activity |
113.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 alpha |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 alpha |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 beta |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 beta |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 delta |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 delta |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 gamma |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Maternal embryonic leucine zipper kinase |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Maternal embryonic leucine zipper kinase |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Microtubule-associated protein tau |
Potency |
7079.5 |
nM |
None |
| Homo sapiens |
Misshapen-like kinase 1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Misshapen-like kinase 1 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myotonin-protein kinase |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myotonin-protein kinase |
Residual Activity |
125.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
NACHT, LRR and PYD domains-containing protein 3 |
Inhibition |
nan |
% |
10.1021/acs.jmedchem.6b01624 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Niemann-Pick C1 protein |
Potency |
115820.8 |
nM |
None |
| Homo sapiens |
NUAK family SNF1-like kinase 1 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
NUAK family SNF1-like kinase 1 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Nuclear factor erythroid 2-related factor 2 |
Potency |
25929.0 |
nM |
None |
| Homo sapiens |
Nuclear factor NF-kappa-B complex |
IC50 |
2000.0 |
nM |
10.1021/np500256w |
| Homo sapiens |
Nuclear factor NF-kappa-B p65 subunit |
Efficacy |
90.0 |
% |
10.1016/j.bmcl.2007.10.100 |
| Homo sapiens |
Nuclear factor NF-kappa-B p65 subunit |
IC50 |
3000.0 |
nM |
10.1016/j.bmcl.2007.10.100 |
| Homo sapiens |
PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
PC-3 |
FC |
0.231 |
None |
10.1038/nchembio790 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C alpha |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C alpha |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C delta |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C delta |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C epsilon |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C epsilon |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C eta |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C eta |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C gamma |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C gamma |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C iota |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C iota |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C mu |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C mu |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C theta |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C theta |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C zeta |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C zeta |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase N2 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase N2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ras-related protein Rab-9A |
Potency |
58047.9 |
nM |
None |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Regulator of G-protein signaling 4 |
Potency |
8.4 |
nM |
None |
| Homo sapiens |
Regulator of G-protein signaling 4 |
Potency |
5972.8 |
nM |
None |
| Homo sapiens |
Rho-associated protein kinase 1 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 1 |
Residual Activity |
119.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 2 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase 1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase 1 |
Residual Activity |
133.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
121.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
125.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT3 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT3 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk1 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk1 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk2 |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk2 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase D2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase D2 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase DCLK2 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase DCLK2 |
Residual Activity |
125.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase EEF2K |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase EEF2K |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase haspin |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase haspin |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK beta |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK beta |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST2 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Potency |
521.2 |
nM |
None |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek11 |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek11 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek3 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK7 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM3 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM3 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK2 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK2 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RIPK2 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk1 |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk2 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk3 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk3 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK1 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK1 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK3 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK3 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO1 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO1 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO2 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO3 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TBK1 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TBK1 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK2 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase VRK2 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase VRK2 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK2 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serum albumin |
Activity |
nan |
None |
10.1016/j.bmcl.2022.128652 |
| Homo sapiens |
SGC-7901 |
Inhibition |
nan |
% |
10.1016/j.ejmech.2017.08.022 |
| Homo sapiens |
SH-SY5Y |
IC50 |
850.0 |
nM |
10.1016/j.bmc.2022.117043 |
| Homo sapiens |
SH-SY5Y |
Potency |
10000.0 |
nM |
None |
| Homo sapiens |
SK-N-AS |
IC50 |
1230.0 |
nM |
10.1016/j.bmc.2022.117043 |
| Homo sapiens |
Stem cell growth factor receptor |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Stem cell growth factor receptor |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TGF-beta receptor type I |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TGF-beta receptor type I |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
THP-1 |
Inhibition |
nan |
% |
10.1021/np400704b |
| Homo sapiens |
THP-1 |
TC50 |
1.5 |
uM |
10.1021/acs.jmedchem.6b01624 |
| Homo sapiens |
Toll-like receptor 4 |
Inhibition |
99.3 |
% |
10.1016/j.bmc.2018.10.035 |
| Homo sapiens |
Tyrosine kinase non-receptor protein 2 |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine kinase non-receptor protein 2 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Residual Activity |
70.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK3 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK3 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SYK |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SYK |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TEC |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TEC |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Residual Activity |
123.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosyl-DNA phosphodiesterase 1 |
Potency |
651.3 |
nM |
None |
| Homo sapiens |
Tyrosyl-DNA phosphodiesterase 1 |
Potency |
1299.5 |
nM |
None |
| Homo sapiens |
Tyrosyl-DNA phosphodiesterase 1 |
Potency |
8912.5 |
nM |
None |
| Homo sapiens |
Tyrosyl-DNA phosphodiesterase 1 |
Potency |
35481.3 |
nM |
None |
| Homo sapiens |
U-937 |
Inhibition |
95.9 |
% |
10.1016/j.bmc.2018.10.035 |
| Homo sapiens |
U-937 |
Inhibition |
99.1 |
% |
10.1016/j.bmc.2018.10.035 |
| Homo sapiens |
U-937 |
Inhibition |
99.2 |
% |
10.1016/j.bmc.2018.10.035 |
| Homo sapiens |
U-937 |
Inhibition |
99.5 |
% |
10.1016/j.bmc.2018.10.035 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vitamin D receptor |
Potency |
3162.3 |
nM |
None |
| Homo sapiens |
Vitamin D receptor |
Potency |
5623.4 |
nM |
None |
| Homo sapiens |
Vitamin D receptor |
Potency |
11220.2 |
nM |
None |
| Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) |
Replicase polyprotein 1ab |
IC50 |
10000.0 |
nM |
10.6019/CHEMBL4495564 |
| Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) |
Replicase polyprotein 1ab |
Inhibition |
17.0 |
% |
10.6019/CHEMBL4495564 |
| Mus musculus |
Gasdermin-D |
Inhibition |
50.0 |
% |
10.1039/C9MD00059C |
| Mus musculus |
NACHT, LRR and PYD domains-containing protein 3 |
IC50 |
12000.0 |
nM |
10.1016/j.ejmech.2019.111822 |
| Mus musculus |
NACHT, LRR and PYD domains-containing protein 3 |
Inhibition |
nan |
% |
10.1021/acs.jmedchem.6b01624 |
| Mus musculus |
Nuclear receptor ROR-gamma |
Potency |
562.3 |
nM |
None |
| Mus musculus |
Nuclear receptor ROR-gamma |
Potency |
1122.0 |
nM |
None |
| Mus musculus |
RAW264.7 |
Activity |
1.2 |
% |
10.1016/j.bmcl.2016.03.088 |
| Mus musculus |
RAW264.7 |
Activity |
nan |
None |
10.1016/j.bmc.2022.116811 |
| Mus musculus |
RAW264.7 |
Inhibition |
nan |
% |
10.1016/j.bmc.2013.11.018 |
| Mus musculus |
RAW264.7 |
Inhibition |
nan |
% |
10.1016/j.bmcl.2016.03.088 |
| Mus musculus |
Transcription factor p65 |
Inhibition |
nan |
% |
10.1016/j.bmcl.2017.02.056 |
| Mus musculus |
Transcription factor p65 |
Inhibition |
nan |
% |
10.1016/j.bmcl.2018.04.033 |
| Mus musculus |
Transcription factor p65 |
Inhibition |
nan |
% |
10.1016/j.ejmech.2017.06.044 |
| Pseudomonas aeruginosa |
Pseudomonas aeruginosa |
IZ |
12.94 |
mm |
10.1016/j.bmcl.2022.128652 |
| Pseudomonas aeruginosa |
Pseudomonas aeruginosa |
MBC |
120.0 |
ug ml-1 |
10.1016/j.bmcl.2022.128652 |
| Pseudomonas aeruginosa |
Pseudomonas aeruginosa |
MIC |
120.0 |
ug.mL-1 |
10.1016/j.bmcl.2022.128652 |
| Rattus norvegicus |
Thioredoxin reductase 1, cytoplasmic |
Potency |
237.8 |
nM |
None |
| Rattus norvegicus |
Thioredoxin reductase 1, cytoplasmic |
Potency |
446.7 |
nM |
None |
| Rattus norvegicus |
Thioredoxin reductase 1, cytoplasmic |
Potency |
946.6 |
nM |
None |
| Saccharomyces cerevisiae |
Saccharomyces cerevisiae |
Potency |
7307.8 |
nM |
None |
| Severe acute respiratory syndrome coronavirus 2 |
Replicase polyprotein 1ab |
IC50 |
820.0 |
nM |
10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 |
Replicase polyprotein 1ab |
Inhibition |
100.17 |
% |
10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
-0.77 |
% |
10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
0.23 |
% |
10.21203/rs.3.rs-23951/v1 |
| Staphylococcus aureus |
Sortase A |
IC50 |
129000.0 |
nM |
10.1016/j.bmcl.2022.128652 |
| Staphylococcus aureus |
Staphylococcus aureus |
IZ |
27.66 |
mm |
10.1016/j.bmcl.2022.128652 |
| Staphylococcus aureus |
Staphylococcus aureus |
IZ |
28.0 |
mm |
10.1016/j.bmcl.2022.128652 |
| Staphylococcus aureus |
Staphylococcus aureus |
MBC |
15.0 |
ug ml-1 |
10.1016/j.bmcl.2022.128652 |
| Staphylococcus aureus |
Staphylococcus aureus |
MBC |
60.0 |
ug ml-1 |
10.1016/j.bmcl.2022.128652 |
| Staphylococcus aureus |
Staphylococcus aureus |
MIC |
1.875 |
ug.mL-1 |
10.1016/j.bmcl.2022.128652 |
| Staphylococcus aureus |
Staphylococcus aureus |
MIC |
7.5 |
ug.mL-1 |
10.1016/j.bmcl.2022.128652 |
| Trypanosoma brucei |
6-phospho-1-fructokinase |
Potency |
3013.1 |
nM |
None |
| None |
ADMET |
Ratio IC50 |
2.0 |
None |
10.1021/np4006635 |
| None |
NON-PROTEIN TARGET |
GI50 |
nan |
None |
10.1016/j.bmc.2013.11.018 |
| None |
NON-PROTEIN TARGET |
IC50 |
nan |
None |
10.1016/j.bmcl.2007.10.100 |
| None |
NON-PROTEIN TARGET |
Inhibition |
95.9 |
% |
10.1016/j.bmcl.2015.11.096 |
| None |
NON-PROTEIN TARGET |
Inhibition |
99.1 |
% |
10.1016/j.bmcl.2015.11.096 |
| None |
NON-PROTEIN TARGET |
Inhibition |
99.2 |
% |
10.1016/j.bmcl.2015.11.096 |
| None |
NON-PROTEIN TARGET |
Inhibition |
99.3 |
% |
10.1016/j.bmcl.2015.11.096 |
| None |
NON-PROTEIN TARGET |
Inhibition |
99.5 |
% |
10.1016/j.bmcl.2015.11.096 |
| None |
Unchecked |
Activity |
nan |
None |
10.1016/j.bmc.2022.116811 |
| None |
Unchecked |
IC50 |
1720.0 |
nM |
10.1016/j.bmc.2013.11.018 |
| None |
Unchecked |
IC50 |
2000.0 |
nM |
10.1016/j.bmcl.2012.07.010 |
| None |
Unchecked |
IC50 |
2000.0 |
nM |
10.1016/j.bmcl.2015.08.063 |
| None |
Unchecked |
IC50 |
2000.0 |
nM |
10.1021/np4006635 |
| None |
Unchecked |
IC50 |
2010.0 |
nM |
10.1021/jm3006806 |
| None |
Unchecked |
IC50 |
5000.0 |
nM |
10.1021/np300534x |
| None |
Unchecked |
IC50 |
5180.0 |
nM |
10.1016/j.ejmech.2021.113277 |
| None |
Unchecked |
IC50 |
9700.0 |
nM |
10.1021/acs.jnatprod.2c00861 |
| None |
Unchecked |
IC50 |
11000.0 |
nM |
10.1021/acs.jnatprod.9b01190 |
| None |
Unchecked |
IC50 |
nan |
None |
10.1016/j.bmcl.2007.10.100 |
| None |
Unchecked |
Inhibition |
9.0 |
% |
10.1016/j.bmc.2011.08.067 |
| None |
Unchecked |
Inhibition |
nan |
% |
10.1016/j.bmc.2013.11.018 |
| None |
Unchecked |
Inhibition |
nan |
% |
10.1016/j.bmcl.2022.128652 |
| None |
Unchecked |
Inhibition |
nan |
% |
10.1021/acs.jmedchem.6b01247 |
| None |
Unchecked |
Inhibition |
nan |
% |
10.1021/acs.jmedchem.7b01185 |
| None |
Unchecked |
Potency |
2818.4 |
nM |
None |
| None |
Unchecked |
Potency |
3548.1 |
nM |
None |
| None |
Unchecked |
Potency |
7079.5 |
nM |
None |
| None |
Unchecked |
Potency |
10000.0 |
nM |
None |
| None |
Unchecked |
Potency |
14125.4 |
nM |
None |
| None |
Unchecked |
Potency |
29081.0 |
nM |
None |
| None |
Unchecked |
Potency |
29092.9 |
nM |
None |
