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name Structure Reference Source Properties Activities Metabolism

(R)-donepezil

AlkaPlorer ID: AK323304

Synonym: None

IUPAC Name: 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

Structure

SMILES: COC1=CC2=C(C=C1OC)C(=O)C(CC1CCN(CC3=CC=CC=C3)CC1)C2

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InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

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InChIKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N

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Reference

PubChem CID: 3152

CAS: 120011-70-3

NPASS: NPC481795

COCONUT: CNP0170523.3

Source

Species Genus Family Order Class Phylum Kingdom Domain
Streptomyces sp. Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria

Properties Information

Molecule Weight: 379.50000000000017

TPSA？: 38.77

MolLogP？: 4.361100000000004

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Artemia salina Artemia salina mortality 26.0 % 10.1016/j.bmc.2018.12.007
Bos taurus Acetylcholinesterase IC50 4.2 nM 10.1016/j.bmc.2012.10.045
Bos taurus Acetylcholinesterase IC50 6.0 nM 10.1016/s0960-894x(98)00076-6
Bos taurus Acetylcholinesterase IC50 8.0 nM 10.1016/s0960-894x(98)00076-6
Bos taurus Acetylcholinesterase IC50 19.0 nM 10.1021/jm8001313
Bos taurus Acetylcholinesterase Ki 2.9 nM 10.1021/jm0255668
Bos taurus Acetylcholinesterase Ki 2.9 nM 10.1021/jm049510k
Bos taurus Monoamine oxidase A IC50 828000.0 nM 10.1016/j.ejmech.2021.113964
Canis lupus familiaris Brain Fu 0.134 None 10.1124/dmd.111.038778
Canis lupus familiaris Canis familiaris F 50.0 % 10.1016/j.bmcl.2014.11.046
Canis lupus familiaris MDCK Papp 306.4 10'-7 cm/s 10.1016/j.ejmech.2014.04.078
Cavia porcellus Sigma-1 receptor Ki 14.6 nM 10.1016/j.ejmech.2018.09.010
Cavia porcellus Sigma-1 receptor Ki 14.6 nM 10.1021/acs.jmedchem.2c01003
Danio rerio Danio rerio Activity 1.88 millimeter/sec 10.1016/j.ejmech.2020.112265
Danio rerio Danio rerio Activity 1.91 millimeter/sec 10.1016/j.ejmech.2019.111958
Danio rerio Danio rerio Activity 4.3 % 10.1021/acs.jmedchem.2c01003
Danio rerio Danio rerio Activity 55.0 % 10.1016/j.ejmech.2020.112180
Danio rerio Danio rerio Activity 66.0 % 10.1016/j.ejmech.2020.112180
Danio rerio Danio rerio Activity 6361.0 mm 10.1016/j.ejmech.2019.111958
Danio rerio Danio rerio Activity 6477.0 mm 10.1016/j.ejmech.2020.112265
Danio rerio Danio rerio Efficacy 55.0 % 10.1016/j.ejmech.2019.111958
Danio rerio Danio rerio Efficacy 57.9 % 10.1016/j.ejmech.2020.112265
Danio rerio Danio rerio Efficacy 64.5 % 10.1016/j.ejmech.2020.112265
Danio rerio Danio rerio Efficacy 66.0 % 10.1016/j.ejmech.2019.111958
Electrophorus electricus Acetylcholinesterase Activity nan None 10.1016/j.ejmech.2017.08.051
Electrophorus electricus Acetylcholinesterase IC50 6.7 nM 10.1016/j.ejmech.2012.03.022
Electrophorus electricus Acetylcholinesterase IC50 6.7 nM 10.1016/j.ejmech.2014.04.078
Electrophorus electricus Acetylcholinesterase IC50 6.7 nM 10.1021/jm200853t
Electrophorus electricus Acetylcholinesterase IC50 6.7 nM None
Electrophorus electricus Acetylcholinesterase IC50 7.0 nM 10.1016/j.ejmech.2016.09.041
Electrophorus electricus Acetylcholinesterase IC50 9.2 nM 10.1016/S0960-894X(00)80545-4
Electrophorus electricus Acetylcholinesterase IC50 10.0 nM 10.1016/j.bmc.2015.01.045
Electrophorus electricus Acetylcholinesterase IC50 10.0 nM 10.1016/j.bmc.2020.115991
Electrophorus electricus Acetylcholinesterase IC50 10.0 nM 10.1016/j.bmcl.2016.04.054
Electrophorus electricus Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2015.01.027
Electrophorus electricus Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2016.08.016
Electrophorus electricus Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2017.07.077
Electrophorus electricus Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2016.09.078
Electrophorus electricus Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2019.111916
Electrophorus electricus Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2021.113397
Electrophorus electricus Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2021.113783
Electrophorus electricus Acetylcholinesterase IC50 12.0 nM 10.1016/j.ejmech.2018.09.010
Electrophorus electricus Acetylcholinesterase IC50 13.0 nM 10.1016/j.ejmech.2013.12.028
Electrophorus electricus Acetylcholinesterase IC50 13.4 nM 10.1021/jm901902w
Electrophorus electricus Acetylcholinesterase IC50 14.0 nM 10.1016/j.ejmech.2013.07.038
Electrophorus electricus Acetylcholinesterase IC50 14.0 nM 10.1016/j.ejmech.2013.10.024
Electrophorus electricus Acetylcholinesterase IC50 14.0 nM 10.1016/j.ejmech.2014.01.017
Electrophorus electricus Acetylcholinesterase IC50 14.0 nM 10.1016/j.ejmech.2015.02.055
Electrophorus electricus Acetylcholinesterase IC50 14.79 nM 10.1016/j.ejmech.2021.114098
Electrophorus electricus Acetylcholinesterase IC50 15.0 nM 10.1016/j.bmc.2019.01.040
Electrophorus electricus Acetylcholinesterase IC50 15.0 nM 10.1016/j.bmcl.2016.02.079
Electrophorus electricus Acetylcholinesterase IC50 15.0 nM 10.1016/j.ejmech.2021.114098
Electrophorus electricus Acetylcholinesterase IC50 16.0 nM 10.1016/j.ejmech.2016.05.014
Electrophorus electricus Acetylcholinesterase IC50 16.0 nM 10.1016/j.ejmech.2021.113973
Electrophorus electricus Acetylcholinesterase IC50 16.3 nM 10.1039/C7MD00199A
Electrophorus electricus Acetylcholinesterase IC50 17.0 nM 10.1016/s0960-894x(98)00076-6
Electrophorus electricus Acetylcholinesterase IC50 18.0 nM 10.1016/j.ejmech.2019.06.026
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.bmc.2017.03.070
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.bmcl.2017.09.055
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.bmcl.2017.09.057
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.bmcl.2019.126625
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.ejmech.2017.02.039
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.ejmech.2019.07.021
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.ejmech.2019.111737
Electrophorus electricus Acetylcholinesterase IC50 19.0 nM 10.1016/j.ejmech.2020.112180
Electrophorus electricus Acetylcholinesterase IC50 20.0 nM 10.1016/j.bmcl.2015.07.052
Electrophorus electricus Acetylcholinesterase IC50 20.0 nM 10.1016/j.bmcl.2017.01.068
Electrophorus electricus Acetylcholinesterase IC50 20.0 nM 10.1016/j.ejmech.2018.04.058
Electrophorus electricus Acetylcholinesterase IC50 20.0 nM 10.1016/j.ejmech.2019.05.055
Electrophorus electricus Acetylcholinesterase IC50 20.0 nM 10.1016/j.ejmech.2022.114841
Electrophorus electricus Acetylcholinesterase IC50 20.0 nM 10.1039/C3MD00041A
Electrophorus electricus Acetylcholinesterase IC50 20.3 nM 10.1039/C2MD20063E
Electrophorus electricus Acetylcholinesterase IC50 21.0 nM 10.1016/j.bmc.2018.11.015
Electrophorus electricus Acetylcholinesterase IC50 21.0 nM 10.1016/j.ejmech.2019.05.062
Electrophorus electricus Acetylcholinesterase IC50 21.0 nM 10.1016/j.ejmech.2021.113663
Electrophorus electricus Acetylcholinesterase IC50 21.0 nM 10.1016/j.ejmech.2022.114806
Electrophorus electricus Acetylcholinesterase IC50 21.0 nM 10.1021/acs.jmedchem.6b00562
Electrophorus electricus Acetylcholinesterase IC50 21.08 nM 10.1016/j.ejmech.2018.02.078
Electrophorus electricus Acetylcholinesterase IC50 22.0 nM 10.1016/j.ejmech.2014.05.056
Electrophorus electricus Acetylcholinesterase IC50 22.0 nM 10.1016/j.ejmech.2019.111613
Electrophorus electricus Acetylcholinesterase IC50 22.6 nM 10.1016/j.bmc.2016.11.048
Electrophorus electricus Acetylcholinesterase IC50 22.6 nM 10.1016/j.bmc.2017.02.027
Electrophorus electricus Acetylcholinesterase IC50 23.0 nM 10.1016/j.bmc.2018.02.037
Electrophorus electricus Acetylcholinesterase IC50 23.0 nM 10.1016/j.bmc.2018.08.035
Electrophorus electricus Acetylcholinesterase IC50 23.0 nM 10.1016/j.bmc.2019.01.025
Electrophorus electricus Acetylcholinesterase IC50 23.0 nM 10.1016/j.bmc.2019.05.023
Electrophorus electricus Acetylcholinesterase IC50 24.0 nM 10.1016/j.ejmech.2018.10.016
Electrophorus electricus Acetylcholinesterase IC50 25.0 nM 10.1016/j.bmc.2021.116074
Electrophorus electricus Acetylcholinesterase IC50 25.0 nM 10.1016/j.ejmech.2019.04.026
Electrophorus electricus Acetylcholinesterase IC50 25.0 nM 10.1016/j.ejmech.2019.111598
Electrophorus electricus Acetylcholinesterase IC50 25.0 nM 10.1016/j.ejmech.2020.112273
Electrophorus electricus Acetylcholinesterase IC50 26.0 nM 10.1016/j.bmcl.2012.04.029
Electrophorus electricus Acetylcholinesterase IC50 26.0 nM 10.1016/j.ejmech.2017.02.043
Electrophorus electricus Acetylcholinesterase IC50 26.0 nM 10.1016/j.ejmech.2018.01.066
Electrophorus electricus Acetylcholinesterase IC50 26.0 nM 10.1016/j.ejmech.2021.113735
Electrophorus electricus Acetylcholinesterase IC50 26.4 nM 10.1016/j.bmc.2020.115400
Electrophorus electricus Acetylcholinesterase IC50 27.0 nM 10.1016/j.ejmech.2017.04.054
Electrophorus electricus Acetylcholinesterase IC50 27.0 nM 10.1016/j.ejmech.2021.113310
Electrophorus electricus Acetylcholinesterase IC50 27.4 nM 10.1016/j.ejmech.2016.12.009
Electrophorus electricus Acetylcholinesterase IC50 28.0 nM 10.1016/j.ejmech.2018.02.002
Electrophorus electricus Acetylcholinesterase IC50 28.7 nM 10.1016/j.bmcl.2016.10.041
Electrophorus electricus Acetylcholinesterase IC50 29.0 nM 10.1016/j.bmcl.2019.126900
Electrophorus electricus Acetylcholinesterase IC50 29.0 nM 10.1016/j.ejmech.2019.111893
Electrophorus electricus Acetylcholinesterase IC50 30.0 nM 10.1016/j.bmc.2022.116952
Electrophorus electricus Acetylcholinesterase IC50 30.0 nM 10.1016/j.ejmech.2014.03.015
Electrophorus electricus Acetylcholinesterase IC50 30.0 nM 10.1016/j.ejmech.2014.03.046
Electrophorus electricus Acetylcholinesterase IC50 30.0 nM 10.1016/j.ejmech.2019.05.039
Electrophorus electricus Acetylcholinesterase IC50 30.0 ug.mL-1 10.1016/j.ejmech.2019.07.059
Electrophorus electricus Acetylcholinesterase IC50 31.0 nM 10.1016/j.bmc.2017.05.043
Electrophorus electricus Acetylcholinesterase IC50 32.0 nM 10.1039/c9md00441f
Electrophorus electricus Acetylcholinesterase IC50 33.0 nM 10.1016/j.bmc.2014.02.046
Electrophorus electricus Acetylcholinesterase IC50 35.0 nM 10.1039/C6MD00053C
Electrophorus electricus Acetylcholinesterase IC50 37.0 nM 10.1016/j.bmc.2017.02.048
Electrophorus electricus Acetylcholinesterase IC50 38.0 nM 10.1016/j.bmc.2016.04.041
Electrophorus electricus Acetylcholinesterase IC50 38.0 nM 10.1016/j.ejmech.2015.10.046
Electrophorus electricus Acetylcholinesterase IC50 38.0 nM 10.1016/j.ejmech.2016.04.053
Electrophorus electricus Acetylcholinesterase IC50 38.0 nM 10.1021/jm401047q
Electrophorus electricus Acetylcholinesterase IC50 38.2 nM 10.1016/j.ejmech.2014.09.081
Electrophorus electricus Acetylcholinesterase IC50 39.0 nM 10.1016/j.bmc.2016.06.027
Electrophorus electricus Acetylcholinesterase IC50 39.0 nM 10.1016/j.bmcl.2020.127477
Electrophorus electricus Acetylcholinesterase IC50 39.0 nM 10.1016/j.ejmech.2016.09.057
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmc.2013.06.003
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmc.2016.02.023
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmc.2016.07.025
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmc.2017.01.010
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmc.2023.117178
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmcl.2013.03.026
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmcl.2022.128602
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.ejmech.2018.11.049
Electrophorus electricus Acetylcholinesterase IC50 40.0 nM 10.1016/j.ejmech.2021.114095
Electrophorus electricus Acetylcholinesterase IC50 40.2 nM 10.1016/j.ejmech.2017.02.045
Electrophorus electricus Acetylcholinesterase IC50 40.74 nM 10.1016/j.bmc.2013.06.003
Electrophorus electricus Acetylcholinesterase IC50 41.0 nM 10.1016/j.bmc.2013.12.066
Electrophorus electricus Acetylcholinesterase IC50 41.1 nM 10.1016/j.ejmech.2019.111785
Electrophorus electricus Acetylcholinesterase IC50 42.0 nM 10.1016/j.bmcl.2015.10.051
Electrophorus electricus Acetylcholinesterase IC50 45.0 nM 10.1016/j.ejmech.2022.114503
Electrophorus electricus Acetylcholinesterase IC50 47.0 nM 10.1016/j.ejmech.2017.04.064
Electrophorus electricus Acetylcholinesterase IC50 47.0 nM 10.1016/j.ejmech.2022.114210
Electrophorus electricus Acetylcholinesterase IC50 47.4 nM 10.1016/j.ejmech.2017.07.055
Electrophorus electricus Acetylcholinesterase IC50 48.0 nM 10.1016/j.bmc.2014.12.057
Electrophorus electricus Acetylcholinesterase IC50 48.0 nM 10.1021/jm001088u
Electrophorus electricus Acetylcholinesterase IC50 49.0 nM 10.1016/j.bmc.2015.08.024
Electrophorus electricus Acetylcholinesterase IC50 49.0 nM 10.1016/j.bmc.2019.06.004
Electrophorus electricus Acetylcholinesterase IC50 49.0 nM 10.1016/j.ejmech.2019.04.038
Electrophorus electricus Acetylcholinesterase IC50 49.0 nM 10.1016/j.ejmech.2020.112761
Electrophorus electricus Acetylcholinesterase IC50 49.0 nM 10.1016/j.ejmech.2021.113492
Electrophorus electricus Acetylcholinesterase IC50 50.0 nM 10.1016/j.bmc.2018.06.018
Electrophorus electricus Acetylcholinesterase IC50 50.0 nM 10.1016/j.bmcl.2016.09.072
Electrophorus electricus Acetylcholinesterase IC50 50.0 nM 10.1016/j.ejmech.2016.10.036
Electrophorus electricus Acetylcholinesterase IC50 50.0 nM 10.1016/j.ejmech.2018.08.005
Electrophorus electricus Acetylcholinesterase IC50 51.0 nM 10.1016/j.ejmech.2016.07.052
Electrophorus electricus Acetylcholinesterase IC50 52.0 nM 10.1016/j.bmc.2022.117146
Electrophorus electricus Acetylcholinesterase IC50 57.0 nM 10.1016/j.bmc.2016.04.015
Electrophorus electricus Acetylcholinesterase IC50 59.9 nM 10.1016/j.bmcl.2015.09.063
Electrophorus electricus Acetylcholinesterase IC50 62.0 nM 10.1016/j.ejmech.2020.113124
Electrophorus electricus Acetylcholinesterase IC50 67.0 nM 10.1016/j.ejmech.2017.08.021
Electrophorus electricus Acetylcholinesterase IC50 80.0 nM 10.1016/j.ejmech.2019.06.088
Electrophorus electricus Acetylcholinesterase IC50 90.0 nM 10.1016/j.bmc.2018.05.050
Electrophorus electricus Acetylcholinesterase IC50 90.0 nM 10.1039/C2MD20076G
Electrophorus electricus Acetylcholinesterase IC50 96.0 nM 10.1021/acs.jmedchem.6b00356
Electrophorus electricus Acetylcholinesterase IC50 100.0 nM 10.1016/j.bmc.2018.01.029
Electrophorus electricus Acetylcholinesterase IC50 110.0 nM 10.1016/j.bmc.2008.07.068
Electrophorus electricus Acetylcholinesterase IC50 110.0 nM 10.1016/j.bmc.2015.01.042
Electrophorus electricus Acetylcholinesterase IC50 110.0 nM 10.1016/j.ejmech.2015.02.063
Electrophorus electricus Acetylcholinesterase IC50 120.0 nM 10.1016/j.bmcl.2009.07.042
Electrophorus electricus Acetylcholinesterase IC50 120.0 nM 10.1016/j.ejmech.2014.02.045
Electrophorus electricus Acetylcholinesterase IC50 219.7 nM 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase IC50 250.0 nM 10.1016/j.ejmech.2021.114044
Electrophorus electricus Acetylcholinesterase IC50 480.0 nM 10.1016/j.bmcl.2021.128306
Electrophorus electricus Acetylcholinesterase IC50 2800.0 nM 10.1016/j.bmc.2019.07.015
Electrophorus electricus Acetylcholinesterase IC50 7230.0 nM 10.1016/j.bmc.2014.08.026
Electrophorus electricus Acetylcholinesterase IC50 7300.0 nM 10.1016/j.bmc.2022.117132
Electrophorus electricus Acetylcholinesterase IC50 26100.0 nM 10.1016/j.bmc.2015.03.051
Electrophorus electricus Acetylcholinesterase Inhibition 0.0 % 10.1016/j.bmc.2007.07.003
Electrophorus electricus Acetylcholinesterase Inhibition 10.85 % 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase Inhibition 11.0 % 10.1016/j.ejmech.2021.113792
Electrophorus electricus Acetylcholinesterase Inhibition 13.0 % 10.1016/j.ejmech.2017.12.084
Electrophorus electricus Acetylcholinesterase Inhibition 17.0 % 10.1021/acs.jmedchem.7b00702
Electrophorus electricus Acetylcholinesterase Inhibition 19.0 % 10.1039/C3MD00041A
Electrophorus electricus Acetylcholinesterase Inhibition 20.96 % 10.1016/j.ejmech.2019.111613
Electrophorus electricus Acetylcholinesterase Inhibition 23.66 % 10.1039/C8MD00312B
Electrophorus electricus Acetylcholinesterase Inhibition 24.0 % 10.1021/acs.jmedchem.5b00115
Electrophorus electricus Acetylcholinesterase Inhibition 25.0 % 10.1016/j.ejmech.2017.07.072
Electrophorus electricus Acetylcholinesterase Inhibition 25.2 % 10.1016/j.bmc.2018.08.035
Electrophorus electricus Acetylcholinesterase Inhibition 25.7 % 10.1016/j.ejmech.2016.04.053
Electrophorus electricus Acetylcholinesterase Inhibition 29.15 % 10.1039/C2MD20063E
Electrophorus electricus Acetylcholinesterase Inhibition 30.18 % 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase Inhibition 37.73 % 10.1016/j.ejmech.2019.111613
Electrophorus electricus Acetylcholinesterase Inhibition 37.9 % 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase Inhibition 50.0 % 10.1016/j.ejmech.2018.02.078
Electrophorus electricus Acetylcholinesterase Inhibition 60.0 % 10.1016/j.ejmech.2018.02.078
Electrophorus electricus Acetylcholinesterase Inhibition 80.33 % 10.1016/j.ejmech.2021.114044
Electrophorus electricus Acetylcholinesterase Inhibition 90.67 % 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase Inhibition 91.07 % 10.1016/j.bmc.2018.01.029
Electrophorus electricus Acetylcholinesterase Inhibition 91.41 % 10.1016/j.ejmech.2021.114044
Electrophorus electricus Acetylcholinesterase Inhibition 91.5 % 10.1021/acs.jnatprod.2c01037
Electrophorus electricus Acetylcholinesterase Inhibition 93.82 % 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase Inhibition 95.0 % 10.1016/j.bmc.2022.117132
Electrophorus electricus Acetylcholinesterase Inhibition 98.36 % 10.1016/j.ejmech.2020.112761
Electrophorus electricus Acetylcholinesterase Inhibition 98.63 % 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase Inhibition 99.0 % 10.1016/j.ejmech.2020.113124
Electrophorus electricus Acetylcholinesterase Inhibition 99.37 % 10.1016/j.ejmech.2016.10.042
Electrophorus electricus Acetylcholinesterase Inhibition 99.4 % 10.1016/j.bmc.2020.115891
Electrophorus electricus Acetylcholinesterase Inhibition 99.4 % 10.1016/j.ejmech.2018.09.010
Electrophorus electricus Acetylcholinesterase Inhibition 99.42 % 10.1016/j.ejmech.2020.112761
Electrophorus electricus Acetylcholinesterase Inhibition 100.0 % 10.1039/C2MD20063E
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1016/j.ejmech.2018.02.078
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1016/j.ejmech.2019.04.026
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1016/j.ejmech.2022.114305
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1021/acsmedchemlett.5b00483
Electrophorus electricus Acetylcholinesterase Ki 4.24 nM 10.1016/j.ejmech.2015.04.055
Electrophorus electricus Acetylcholinesterase Ki 16.4 nM 10.1016/j.ejmech.2019.04.026
Electrophorus electricus Acetylcholinesterase Ki 38.0 nM 10.1016/j.ejmech.2017.02.043
Electrophorus electricus Acetylcholinesterase Ki 56.0 nM 10.1016/j.bmc.2013.06.003
Equus caballus Butyrylcholinesterase IC50 2900.0 nM 10.1021/jm00043a012
Equus caballus Butyrylcholinesterase IC50 3365.4 nM 10.1016/j.ejmech.2014.09.081
Equus caballus Butyrylcholinesterase IC50 4166.7 nM 10.1016/S0960-894X(00)80545-4
Equus caballus Butyrylcholinesterase IC50 7400.0 nM 10.1016/j.ejmech.2012.03.022
Equus caballus Butyrylcholinesterase IC50 7400.0 nM None
Equus caballus Butyrylcholinesterase IC50 nan None 10.1039/C3MD00041A
Equus caballus Butyrylcholinesterase Ki 640.0 nM 10.1021/jm0255668
Equus caballus Butyrylcholinesterase Ki 640.0 nM 10.1021/jm049510k
Equus caballus Cholinesterase Activity 50.9 % 10.1016/j.ejmech.2019.07.021
Equus caballus Cholinesterase Activity 54.1 % 10.1016/j.ejmech.2019.06.026
Equus caballus Cholinesterase Activity 60.5 % 10.1016/j.ejmech.2019.07.021
Equus caballus Cholinesterase Activity 62.9 % 10.1016/j.ejmech.2019.06.026
Equus caballus Cholinesterase Activity 103.9 % 10.1016/j.ejmech.2019.06.026
Equus caballus Cholinesterase Activity 126.8 % 10.1016/j.ejmech.2019.07.021
Equus caballus Cholinesterase IC50 4.6 nM 10.1016/j.ejmech.2017.07.055
Equus caballus Cholinesterase IC50 130.0 nM 10.1016/j.bmc.2018.05.050
Equus caballus Cholinesterase IC50 231.0 nM 10.1016/j.bmcl.2018.07.019
Equus caballus Cholinesterase IC50 350.0 nM 10.1016/j.bmc.2018.08.035
Equus caballus Cholinesterase IC50 350.0 nM 10.1016/j.ejmech.2018.05.031
Equus caballus Cholinesterase IC50 540.0 nM 10.1016/j.bmcl.2015.10.051
Equus caballus Cholinesterase IC50 840.0 nM 10.1016/j.ejmech.2013.12.028
Equus caballus Cholinesterase IC50 840.0 nM 10.1021/jm901902w
Equus caballus Cholinesterase IC50 941.0 nM 10.1016/j.ejmech.2019.111613
Equus caballus Cholinesterase IC50 1260.0 nM 10.1021/acs.jmedchem.6b00426
Equus caballus Cholinesterase IC50 1270.0 nM 10.1021/acsmedchemlett.5b00483
Equus caballus Cholinesterase IC50 1300.0 nM 10.1016/j.bmc.2021.116355
Equus caballus Cholinesterase IC50 1340.0 nM 10.1016/j.bmcl.2018.07.019
Equus caballus Cholinesterase IC50 1820.0 nM 10.1016/j.bmc.2014.02.046
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.bmc.2015.01.045
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.bmcl.2016.04.054
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2015.01.027
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2016.08.016
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2016.09.078
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2019.111785
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2019.111916
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2021.113397
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2021.113783
Equus caballus Cholinesterase IC50 1830.0 nM 10.1016/j.ejmech.2021.113792
Equus caballus Cholinesterase IC50 1900.0 nM 10.1016/j.bmc.2012.10.045
Equus caballus Cholinesterase IC50 1911.0 nM 10.1016/j.bmc.2014.12.057
Equus caballus Cholinesterase IC50 1960.0 nM 10.1039/C7MD00199A
Equus caballus Cholinesterase IC50 1980.0 nM 10.1016/j.ejmech.2021.113278
Equus caballus Cholinesterase IC50 2057.0 nM 10.1016/j.ejmech.2021.113278
Equus caballus Cholinesterase IC50 2100.0 nM 10.1016/j.ejmech.2018.10.016
Equus caballus Cholinesterase IC50 2100.0 nM 10.1021/acs.jmedchem.1c01784
Equus caballus Cholinesterase IC50 2160.0 nM 10.1016/j.bmc.2021.116385
Equus caballus Cholinesterase IC50 2200.0 nM 10.1016/j.ejmech.2019.04.026
Equus caballus Cholinesterase IC50 2300.0 nM 10.1016/j.bmcl.2017.01.068
Equus caballus Cholinesterase IC50 2300.0 nM 10.1016/j.ejmech.2019.05.062
Equus caballus Cholinesterase IC50 2310.0 nM 10.1021/acs.jmedchem.6b00562
Equus caballus Cholinesterase IC50 2470.0 nM 10.1039/c9md00441f
Equus caballus Cholinesterase IC50 2480.0 nM 10.1016/j.ejmech.2016.07.052
Equus caballus Cholinesterase IC50 2480.0 nM 10.1016/j.ejmech.2018.08.005
Equus caballus Cholinesterase IC50 2500.0 nM 10.1016/j.ejmech.2013.11.026
Equus caballus Cholinesterase IC50 2580.0 nM 10.1016/j.ejmech.2016.04.053
Equus caballus Cholinesterase IC50 2600.0 nM 10.1016/j.bmcl.2019.126900
Equus caballus Cholinesterase IC50 2660.0 nM 10.1016/j.ejmech.2021.114044
Equus caballus Cholinesterase IC50 2700.0 nM 10.1016/j.ejmech.2007.04.018
Equus caballus Cholinesterase IC50 2720.0 nM 10.1016/j.ejmech.2017.04.064
Equus caballus Cholinesterase IC50 2870.0 nM 10.1016/j.ejmech.2016.09.041
Equus caballus Cholinesterase IC50 2890.0 nM 10.1016/j.ejmech.2017.07.077
Equus caballus Cholinesterase IC50 2890.0 nM 10.1016/j.ejmech.2020.112257
Equus caballus Cholinesterase IC50 3060.0 nM 10.1016/j.bmc.2017.02.048
Equus caballus Cholinesterase IC50 3140.0 nM 10.1016/j.bmc.2016.04.041
Equus caballus Cholinesterase IC50 3200.0 nM 10.1016/j.bmc.2018.06.018
Equus caballus Cholinesterase IC50 3310.0 nM 10.1016/j.ejmech.2015.02.055
Equus caballus Cholinesterase IC50 3360.0 nM 10.1016/j.bmc.2016.06.027
Equus caballus Cholinesterase IC50 3360.0 nM 10.1016/j.bmc.2016.07.025
Equus caballus Cholinesterase IC50 3360.0 nM 10.1016/j.ejmech.2016.09.057
Equus caballus Cholinesterase IC50 3365.0 nM 10.1016/j.ejmech.2017.12.084
Equus caballus Cholinesterase IC50 3365.0 nM 10.1021/jm401047q
Equus caballus Cholinesterase IC50 3400.0 nM 10.1016/j.ejmech.2018.04.058
Equus caballus Cholinesterase IC50 3490.0 nM 10.1016/j.bmc.2013.12.066
Equus caballus Cholinesterase IC50 3540.0 nM 10.1016/j.bmc.2020.115991
Equus caballus Cholinesterase IC50 3550.0 nM 10.1016/j.ejmech.2020.113124
Equus caballus Cholinesterase IC50 3550.0 nM 10.1016/j.ejmech.2021.114095
Equus caballus Cholinesterase IC50 3600.0 nM 10.1016/j.bmcl.2012.05.077
Equus caballus Cholinesterase IC50 3620.0 nM 10.1016/j.bmcl.2015.09.063
Equus caballus Cholinesterase IC50 3790.0 nM 10.1016/j.bmc.2016.02.023
Equus caballus Cholinesterase IC50 4170.0 nM 10.1039/C6MD00053C
Equus caballus Cholinesterase IC50 4260.0 nM 10.1016/j.bmc.2022.117146
Equus caballus Cholinesterase IC50 4460.0 nM 10.1016/j.bmc.2015.03.051
Equus caballus Cholinesterase IC50 4500.0 nM 10.1016/j.ejmech.2017.02.045
Equus caballus Cholinesterase IC50 4660.0 nM 10.1016/j.bmcl.2012.04.029
Equus caballus Cholinesterase IC50 4690.0 nM 10.1016/j.ejmech.2017.02.043
Equus caballus Cholinesterase IC50 4690.0 nM 10.1016/j.ejmech.2018.01.066
Equus caballus Cholinesterase IC50 4700.0 nM 10.1016/j.bmc.2022.116952
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.bmc.2017.03.070
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.bmcl.2017.09.055
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.bmcl.2017.09.057
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.bmcl.2019.126625
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.ejmech.2017.02.039
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.ejmech.2019.06.026
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.ejmech.2019.07.021
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.ejmech.2019.111737
Equus caballus Cholinesterase IC50 4760.0 nM 10.1016/j.ejmech.2020.112180
Equus caballus Cholinesterase IC50 4900.0 nM 10.1039/C9MD00030E
Equus caballus Cholinesterase IC50 5130.0 nM 10.1016/j.bmc.2023.117178
Equus caballus Cholinesterase IC50 5200.0 nM 10.1016/j.ejmech.2019.06.088
Equus caballus Cholinesterase IC50 5380.0 nM 10.1016/j.ejmech.2013.07.038
Equus caballus Cholinesterase IC50 5380.0 nM 10.1016/j.ejmech.2013.10.024
Equus caballus Cholinesterase IC50 5380.0 nM 10.1016/j.ejmech.2014.01.017
Equus caballus Cholinesterase IC50 5520.0 nM 10.1016/j.ejmech.2020.112761
Equus caballus Cholinesterase IC50 5520.0 nM 10.1039/C2MD20076G
Equus caballus Cholinesterase IC50 5910.0 nM 10.1021/acs.jmedchem.6b00356
Equus caballus Cholinesterase IC50 6410.0 nM 10.1016/j.ejmech.2022.114210
Equus caballus Cholinesterase IC50 6500.0 nM 10.1016/j.bmc.2016.04.015
Equus caballus Cholinesterase IC50 7000.0 nM 10.1021/acs.jmedchem.5b00115
Equus caballus Cholinesterase IC50 7200.0 nM 10.1016/j.bmc.2019.05.023
Equus caballus Cholinesterase IC50 7300.0 nM 10.1016/j.ejmech.2014.05.056
Equus caballus Cholinesterase IC50 7390.0 nM 10.1016/j.ejmech.2021.113973
Equus caballus Cholinesterase IC50 7400.0 nM 10.1016/j.ejmech.2014.04.078
Equus caballus Cholinesterase IC50 7400.0 nM 10.1016/j.ejmech.2016.05.014
Equus caballus Cholinesterase IC50 7400.0 nM 10.1021/jm200853t
Equus caballus Cholinesterase IC50 7690.0 nM 10.1016/j.ejmech.2015.10.046
Equus caballus Cholinesterase IC50 7870.0 nM 10.1016/j.ejmech.2019.05.055
Equus caballus Cholinesterase IC50 8400.0 nM 10.1016/j.bmc.2019.07.015
Equus caballus Cholinesterase IC50 8416.0 nM 10.1016/j.bmcl.2020.127477
Equus caballus Cholinesterase IC50 8710.0 nM 10.1016/j.bmc.2015.08.024
Equus caballus Cholinesterase IC50 8710.0 nM 10.1016/j.bmc.2019.06.004
Equus caballus Cholinesterase IC50 8710.0 nM 10.1016/j.ejmech.2019.04.038
Equus caballus Cholinesterase IC50 8730.0 nM 10.1016/j.bmc.2017.05.043
Equus caballus Cholinesterase IC50 9240.0 nM 10.1016/j.ejmech.2021.113735
Equus caballus Cholinesterase IC50 10380.0 nM 10.1016/j.ejmech.2019.111598
Equus caballus Cholinesterase IC50 10380.0 nM 10.1016/j.ejmech.2020.112273
Equus caballus Cholinesterase IC50 10600.0 nM 10.1016/j.bmcl.2021.128306
Equus caballus Cholinesterase IC50 11810.0 nM 10.1016/j.ejmech.2018.02.002
Equus caballus Cholinesterase IC50 15240.0 nM 10.1016/j.bmc.2017.01.010
Equus caballus Cholinesterase IC50 35400.0 nM 10.1016/j.ejmech.2022.114503
Equus caballus Cholinesterase IC50 nan None 10.1016/j.bmc.2018.01.029
Equus caballus Cholinesterase Inhibition 24.71 % 10.1016/j.ejmech.2020.112761
Equus caballus Cholinesterase Inhibition 50.0 % 10.1016/j.ejmech.2021.113792
Equus caballus Cholinesterase Inhibition 65.68 % 10.1016/j.ejmech.2020.112257
Equus caballus Cholinesterase Inhibition 67.85 % 10.1016/j.ejmech.2020.112761
Equus caballus Cholinesterase Inhibition 80.0 % 10.1016/j.ejmech.2021.114095
Equus caballus Cholinesterase Inhibition 88.0 % 10.1016/j.ejmech.2020.113124
Equus caballus Cholinesterase Inhibition 88.34 % 10.1016/j.ejmech.2021.114044
Equus caballus Cholinesterase Inhibition 91.3 % 10.1021/acs.jnatprod.2c01037
Equus caballus Cholinesterase Inhibition 94.1 % 10.1016/j.ejmech.2019.111893
Equus caballus Cholinesterase Inhibition 94.38 % 10.1016/j.ejmech.2021.114044
Equus caballus Cholinesterase Inhibition nan % 10.1016/j.bmc.2018.01.029
Equus caballus Cholinesterase Inhibition nan % 10.1016/j.ejmech.2021.113783
Equus caballus Cholinesterase Inhibition nan % 10.1021/acsmedchemlett.5b00483
Equus caballus Cholinesterase Ki 2140.0 nM 10.1021/acsmedchemlett.5b00483
Felis catus Felis catus ED50 0.53 umol.kg-1 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus HR -12.0 delta % 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus MAP -12.0 delta % 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus Max rev 106.0 % 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus Vagus 14.0 delta % 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholine receptor protein epsilon chain IC50 32.36 nM 10.1016/j.ejmech.2021.114098
Homo sapiens Acetylcholine receptor protein epsilon chain Inhibition 28.5 % 10.1016/j.ejmech.2019.02.030
Homo sapiens Acetylcholine receptor protein epsilon chain Inhibition 83.9 % 10.1016/j.ejmech.2019.07.059
Homo sapiens Acetylcholine receptor protein epsilon chain Inhibition 90.55 % 10.1016/j.ejmech.2017.10.006
Homo sapiens Acetylcholinesterase AC50 16.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase AC50 95.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase Activity 8.2 % 10.1016/j.bmcl.2022.128574
Homo sapiens Acetylcholinesterase Activity 22.0 % 10.1021/jm7009364
Homo sapiens Acetylcholinesterase Activity 50.4 % 10.1016/j.bmcl.2022.128574
Homo sapiens Acetylcholinesterase Activity 50.6 % 10.1016/j.ejmech.2019.111958
Homo sapiens Acetylcholinesterase Activity 50.6 % 10.1016/j.ejmech.2020.112180
Homo sapiens Acetylcholinesterase Activity 53.6 % 10.1016/j.bmcl.2022.128574
Homo sapiens Acetylcholinesterase Activity 58.5 % 10.1016/j.ejmech.2019.111958
Homo sapiens Acetylcholinesterase Activity 58.5 % 10.1016/j.ejmech.2020.112180
Homo sapiens Acetylcholinesterase Activity 61.8 % 10.1016/j.bmcl.2022.128574
Homo sapiens Acetylcholinesterase Activity 66.0 % 10.1016/j.ejmech.2019.111958
Homo sapiens Acetylcholinesterase Activity 66.0 % 10.1016/j.ejmech.2020.112180
Homo sapiens Acetylcholinesterase Activity 81.6 % 10.1016/j.ejmech.2020.113124
Homo sapiens Acetylcholinesterase Activity 89.0 % 10.1016/j.ejmech.2020.113124
Homo sapiens Acetylcholinesterase Activity 96.8 % 10.1016/j.bmcl.2022.128574
Homo sapiens Acetylcholinesterase Activity 101.4 % 10.1016/j.ejmech.2019.111958
Homo sapiens Acetylcholinesterase EC50 43.0 nM 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholinesterase Flu intensity 0.48 None 10.1016/j.ejmech.2019.111707
Homo sapiens Acetylcholinesterase IC50 2.0 nM 10.1016/j.bmc.2012.10.045
Homo sapiens Acetylcholinesterase IC50 2.33 nM 10.1016/S0960-894X(00)80545-4
Homo sapiens Acetylcholinesterase IC50 3.46 10'3pM 10.1016/j.ejmech.2017.07.006
Homo sapiens Acetylcholinesterase IC50 4.0 nM 10.1016/j.ejmech.2022.114242
Homo sapiens Acetylcholinesterase IC50 5.0 nM 10.1016/j.bmc.2020.115940
Homo sapiens Acetylcholinesterase IC50 5.59 nM 10.1016/j.ejmech.2019.111785
Homo sapiens Acetylcholinesterase IC50 5.7 nM 10.1016/j.bmc.2012.11.044
Homo sapiens Acetylcholinesterase IC50 5.7 nM 10.1016/j.bmc.2018.12.030
Homo sapiens Acetylcholinesterase IC50 5.7 nM 10.1016/j.bmc.2019.01.025
Homo sapiens Acetylcholinesterase IC50 5.7 nM 10.1016/j.ejmech.2017.08.051
Homo sapiens Acetylcholinesterase IC50 5.7 nM 10.1016/j.ejmech.2018.01.007
Homo sapiens Acetylcholinesterase IC50 5.7 nM 10.1016/j.ejmech.2018.01.066
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1016/j.bmc.2015.01.045
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1016/j.bmcl.2010.12.041
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1016/j.ejmech.2015.01.027
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1016/j.ejmech.2016.08.016
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1016/j.ejmech.2018.10.064
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1016/j.ejmech.2020.112743
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1021/acs.jmedchem.5b00115
Homo sapiens Acetylcholinesterase IC50 6.0 nM 10.1039/d0md00009d
Homo sapiens Acetylcholinesterase IC50 6.2 nM 10.1039/C9MD00030E
Homo sapiens Acetylcholinesterase IC50 6.87 nM 10.1016/j.bmcl.2018.07.019
Homo sapiens Acetylcholinesterase IC50 7.0 nM 10.1016/j.ejmech.2020.113059
Homo sapiens Acetylcholinesterase IC50 7.0 nM 10.1021/acsmedchemlett.6b00099
Homo sapiens Acetylcholinesterase IC50 7.39 nM 10.1016/j.ejmech.2021.114045
Homo sapiens Acetylcholinesterase IC50 7.998 nM 10.1021/jm950704x
Homo sapiens Acetylcholinesterase IC50 8.0 nM 10.1016/j.bmc.2014.08.016
Homo sapiens Acetylcholinesterase IC50 8.0 nM 10.1016/j.ejmech.2009.12.038
Homo sapiens Acetylcholinesterase IC50 8.0 nM 10.1016/s0960-894x(98)00076-6
Homo sapiens Acetylcholinesterase IC50 8.0 nM 10.1021/jm00007a005
Homo sapiens Acetylcholinesterase IC50 8.0 nM 10.1021/jm00043a012
Homo sapiens Acetylcholinesterase IC50 8.2 nM 10.1021/jm901902w
Homo sapiens Acetylcholinesterase IC50 9.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Acetylcholinesterase IC50 9.0 nM 10.1016/j.ejmech.2020.112180
Homo sapiens Acetylcholinesterase IC50 9.0 nM 10.1021/acs.jmedchem.0c01192
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.bmc.2016.02.023
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2012.09.030
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2013.06.021
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2013.11.026
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2016.05.055
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2017.02.034
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2018.07.026
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2018.07.056
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2019.01.030
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1016/j.ejmech.2021.113541
Homo sapiens Acetylcholinesterase IC50 10.0 nM 10.1021/acs.jmedchem.6b00426
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1016/j.bmc.2013.12.066
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2014.02.045
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2017.02.039
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2019.111737
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1016/j.ejmech.2019.111958
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1021/acsmedchemlett.5b00483
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1021/jm401047q
Homo sapiens Acetylcholinesterase IC50 11.0 nM 10.1039/C3MD00041A
Homo sapiens Acetylcholinesterase IC50 11.7 nM 10.1016/j.ejmech.2014.09.081
Homo sapiens Acetylcholinesterase IC50 12.0 nM 10.1016/j.ejmech.2015.02.063
Homo sapiens Acetylcholinesterase IC50 12.0 nM 10.1016/j.ejmech.2017.04.054
Homo sapiens Acetylcholinesterase IC50 12.1 nM 10.1016/j.ejmech.2019.111596
Homo sapiens Acetylcholinesterase IC50 14.0 nM 10.1016/j.ejmech.2015.08.052
Homo sapiens Acetylcholinesterase IC50 14.0 nM 10.1016/j.ejmech.2020.112140
Homo sapiens Acetylcholinesterase IC50 15.0 nM 10.1021/acs.jmedchem.5b00599
Homo sapiens Acetylcholinesterase IC50 16.0 nM 10.1016/j.bmc.2023.117256
Homo sapiens Acetylcholinesterase IC50 16.0 nM 10.1016/j.ejmech.2019.05.062
Homo sapiens Acetylcholinesterase IC50 16.0 nM 10.1021/jm001088u
Homo sapiens Acetylcholinesterase IC50 16.0 nM 10.1021/jm501501a
Homo sapiens Acetylcholinesterase IC50 16.0 nM 10.1021/jm981101z
Homo sapiens Acetylcholinesterase IC50 16.1 nM 10.1021/acsmedchemlett.9b00656
Homo sapiens Acetylcholinesterase IC50 17.0 nM 10.1016/j.ejmech.2022.114358
Homo sapiens Acetylcholinesterase IC50 17.0 nM 10.1039/d2md00042c
Homo sapiens Acetylcholinesterase IC50 17.76 nM 10.1016/j.bmcl.2020.127659
Homo sapiens Acetylcholinesterase IC50 18.0 nM 10.1016/j.ejmech.2021.113735
Homo sapiens Acetylcholinesterase IC50 18.0 nM 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholinesterase IC50 18.0 nM 10.1021/jm101299d
Homo sapiens Acetylcholinesterase IC50 19.0 nM 10.1016/j.bmcl.2017.09.055
Homo sapiens Acetylcholinesterase IC50 20.0 nM 10.1016/j.bmc.2010.01.071
Homo sapiens Acetylcholinesterase IC50 20.0 nM 10.1016/j.ejmech.2008.02.035
Homo sapiens Acetylcholinesterase IC50 20.3 nM 10.1016/j.ejmech.2017.09.022
Homo sapiens Acetylcholinesterase IC50 21.0 nM 10.1016/j.ejmech.2013.01.060
Homo sapiens Acetylcholinesterase IC50 22.0 nM 10.1016/j.bmc.2016.01.031
Homo sapiens Acetylcholinesterase IC50 22.0 nM 10.1016/j.ejmech.2011.02.071
Homo sapiens Acetylcholinesterase IC50 22.0 nM 10.1016/j.ejmech.2018.07.033
Homo sapiens Acetylcholinesterase IC50 22.0 nM 10.1021/jm010491d
Homo sapiens Acetylcholinesterase IC50 22.0 nM 10.1021/jm049309+
Homo sapiens Acetylcholinesterase IC50 22.0 nM 10.1021/jm050578p
Homo sapiens Acetylcholinesterase IC50 22.91 nM 10.1021/jm0494366
Homo sapiens Acetylcholinesterase IC50 23.0 nM 10.1016/j.ejmech.2011.02.019
Homo sapiens Acetylcholinesterase IC50 23.0 nM 10.1021/acs.jmedchem.1c01784
Homo sapiens Acetylcholinesterase IC50 23.0 nM 10.1021/jm7009364
Homo sapiens Acetylcholinesterase IC50 23.1 nM 10.1021/jm0340602
Homo sapiens Acetylcholinesterase IC50 23.1 nM 10.1021/jm070559a
Homo sapiens Acetylcholinesterase IC50 23.1 nM 10.1021/jm8009684
Homo sapiens Acetylcholinesterase IC50 24.7 nM 10.1039/C7MD00199A
Homo sapiens Acetylcholinesterase IC50 25.0 nM 10.1016/j.bmcl.2022.128976
Homo sapiens Acetylcholinesterase IC50 26.55 nM 10.1016/j.ejmech.2021.113224
Homo sapiens Acetylcholinesterase IC50 26.8 nM 10.1016/j.ejmech.2021.113779
Homo sapiens Acetylcholinesterase IC50 30.0 nM 10.1016/j.ejmech.2017.02.042
Homo sapiens Acetylcholinesterase IC50 30.0 nM 10.1016/j.ejmech.2020.112257
Homo sapiens Acetylcholinesterase IC50 30.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens Acetylcholinesterase IC50 30.8 nM 10.1039/C6MD00053C
Homo sapiens Acetylcholinesterase IC50 31.8 nM 10.1016/j.ejmech.2017.07.055
Homo sapiens Acetylcholinesterase IC50 32.0 nM 10.1016/j.bmc.2021.116074
Homo sapiens Acetylcholinesterase IC50 32.0 nM 10.1016/j.bmcl.2012.05.077
Homo sapiens Acetylcholinesterase IC50 32.0 nM 10.1016/j.ejmech.2021.113492
Homo sapiens Acetylcholinesterase IC50 33.0 nM 10.1016/j.ejmech.2019.02.030
Homo sapiens Acetylcholinesterase IC50 35.6 nM 10.1016/j.ejmech.2016.12.009
Homo sapiens Acetylcholinesterase IC50 37.6 nM 10.1016/j.ejmech.2017.02.045
Homo sapiens Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmc.2019.07.001
Homo sapiens Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmcl.2013.05.092
Homo sapiens Acetylcholinesterase IC50 40.0 nM 10.1021/jm0109356
Homo sapiens Acetylcholinesterase IC50 40.0 nM 10.1039/C5MD00274E
Homo sapiens Acetylcholinesterase IC50 41.0 nM 10.1016/j.ejmech.2018.01.055
Homo sapiens Acetylcholinesterase IC50 42.0 nM 10.1016/j.bmc.2020.115721
Homo sapiens Acetylcholinesterase IC50 42.0 nM 10.1016/j.ejmech.2019.111707
Homo sapiens Acetylcholinesterase IC50 44.0 nM 10.1016/j.ejmech.2021.113663
Homo sapiens Acetylcholinesterase IC50 44.0 nM 10.1016/j.ejmech.2022.114806
Homo sapiens Acetylcholinesterase IC50 48.0 nM 10.1016/j.ejmech.2016.07.052
Homo sapiens Acetylcholinesterase IC50 48.0 nM 10.1016/j.ejmech.2018.08.005
Homo sapiens Acetylcholinesterase IC50 48.0 nM 10.1016/j.ejmech.2020.113124
Homo sapiens Acetylcholinesterase IC50 50.12 nM 10.1016/j.bmcl.2017.07.013
Homo sapiens Acetylcholinesterase IC50 54.0 nM 10.1016/j.ejmech.2022.114152
Homo sapiens Acetylcholinesterase IC50 59.0 nM 10.1016/j.ejmech.2019.111651
Homo sapiens Acetylcholinesterase IC50 59.0 nM 10.1016/j.ejmech.2021.113964
Homo sapiens Acetylcholinesterase IC50 60.0 nM 10.1016/j.bmc.2021.116385
Homo sapiens Acetylcholinesterase IC50 60.0 nM 10.1021/acs.jmedchem.2c01003
Homo sapiens Acetylcholinesterase IC50 62.0 nM 10.1016/j.ejmech.2014.06.034
Homo sapiens Acetylcholinesterase IC50 87.0 nM 10.1039/d2md00262k
Homo sapiens Acetylcholinesterase IC50 90.0 nM 10.1016/j.bmc.2016.10.016
Homo sapiens Acetylcholinesterase IC50 90.0 nM 10.1021/jm100573q
Homo sapiens Acetylcholinesterase IC50 120.0 nM 10.1016/j.bmc.2016.07.025
Homo sapiens Acetylcholinesterase IC50 120.0 nM 10.1016/j.bmcl.2010.09.108
Homo sapiens Acetylcholinesterase IC50 147.91 nM 10.1016/j.bmc.2019.02.031
Homo sapiens Acetylcholinesterase IC50 160.0 nM 10.1016/j.bmc.2007.12.048
Homo sapiens Acetylcholinesterase IC50 160.0 nM 10.1016/j.ejmech.2017.07.077
Homo sapiens Acetylcholinesterase IC50 2170.0 nM 10.1016/j.ejmech.2020.112368
Homo sapiens Acetylcholinesterase IC50 4150.0 nM 10.1016/j.ejmech.2011.02.071
Homo sapiens Acetylcholinesterase IC50 7120.0 nM 10.1021/acs.jmedchem.0c00756
Homo sapiens Acetylcholinesterase IC50 7560.0 nM 10.1016/j.bmcl.2020.127370
Homo sapiens Acetylcholinesterase IC50 100000.0 nM 10.1021/jm100293f
Homo sapiens Acetylcholinesterase IC50 198000.0 nM 10.1016/j.ejmech.2022.114841
Homo sapiens Acetylcholinesterase IC50 nan None 10.1016/j.bmc.2021.116355
Homo sapiens Acetylcholinesterase IC50 nan None 10.1021/jm0503289
Homo sapiens Acetylcholinesterase Inhibition 0.0 % 10.1021/jm0503289
Homo sapiens Acetylcholinesterase Inhibition 8.87 % 10.1016/j.bmc.2021.116385
Homo sapiens Acetylcholinesterase Inhibition 10.14 % 10.1016/j.ejmech.2020.112257
Homo sapiens Acetylcholinesterase Inhibition 11.65 % 10.1016/j.bmc.2021.116385
Homo sapiens Acetylcholinesterase Inhibition 13.95 % 10.1016/j.ejmech.2020.112257
Homo sapiens Acetylcholinesterase Inhibition 16.9 % 10.1016/j.bmc.2020.115721
Homo sapiens Acetylcholinesterase Inhibition 16.9 % 10.1016/j.ejmech.2019.111707
Homo sapiens Acetylcholinesterase Inhibition 18.0 % 10.1016/j.bmc.2019.02.031
Homo sapiens Acetylcholinesterase Inhibition 18.8 % 10.1016/j.ejmech.2015.02.063
Homo sapiens Acetylcholinesterase Inhibition 18.8 % 10.1016/j.ejmech.2017.04.054
Homo sapiens Acetylcholinesterase Inhibition 18.9 % 10.1016/j.ejmech.2021.113541
Homo sapiens Acetylcholinesterase Inhibition 19.1 % 10.1016/j.bmc.2021.116385
Homo sapiens Acetylcholinesterase Inhibition 19.8 % 10.1016/j.ejmech.2021.114098
Homo sapiens Acetylcholinesterase Inhibition 20.1 % 10.1016/j.ejmech.2021.113310
Homo sapiens Acetylcholinesterase Inhibition 21.1 % 10.1021/jm401047q
Homo sapiens Acetylcholinesterase Inhibition 21.65 % 10.1016/j.ejmech.2020.112257
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1016/j.bmc.2010.01.071
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1016/j.bmc.2013.09.050
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1016/j.ejmech.2011.02.019
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1016/j.ejmech.2018.02.083
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1016/j.ejmech.2019.02.021
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1021/jm0494366
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1021/jm200853t
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1021/jm8009684
Homo sapiens Acetylcholinesterase Inhibition 22.0 % 10.1039/C3MD00041A
Homo sapiens Acetylcholinesterase Inhibition 22.6 % 10.1016/j.ejmech.2019.02.030
Homo sapiens Acetylcholinesterase Inhibition 24.0 % 10.1016/j.bmc.2020.115721
Homo sapiens Acetylcholinesterase Inhibition 25.0 % 10.1016/j.bmcl.2016.02.079
Homo sapiens Acetylcholinesterase Inhibition 25.0 % 10.1016/j.ejmech.2014.02.045
Homo sapiens Acetylcholinesterase Inhibition 26.1 % 10.1016/j.ejmech.2018.04.058
Homo sapiens Acetylcholinesterase Inhibition 26.4 % 10.1016/j.ejmech.2016.07.052
Homo sapiens Acetylcholinesterase Inhibition 26.7 % 10.1016/j.ejmech.2019.111958
Homo sapiens Acetylcholinesterase Inhibition 26.7 % 10.1016/j.ejmech.2020.112180
Homo sapiens Acetylcholinesterase Inhibition 27.96 % 10.1016/j.bmc.2021.116385
Homo sapiens Acetylcholinesterase Inhibition 30.88 % 10.1016/j.ejmech.2020.112257
Homo sapiens Acetylcholinesterase Inhibition 32.0 % 10.1016/j.bmc.2020.115721
Homo sapiens Acetylcholinesterase Inhibition 32.0 % 10.1016/j.ejmech.2019.111707
Homo sapiens Acetylcholinesterase Inhibition 33.6 % 10.1016/j.ejmech.2019.02.030
Homo sapiens Acetylcholinesterase Inhibition 37.26 % 10.1021/acs.jmedchem.6b00426
Homo sapiens Acetylcholinesterase Inhibition 40.9 % 10.1016/j.bmc.2019.07.001
Homo sapiens Acetylcholinesterase Inhibition 50.0 % 10.1016/j.ejmech.2017.02.042
Homo sapiens Acetylcholinesterase Inhibition 51.7 % 10.1016/j.ejmech.2017.02.045
Homo sapiens Acetylcholinesterase Inhibition 95.19 % 10.1016/j.ejmech.2016.09.052
Homo sapiens Acetylcholinesterase Inhibition 96.81 % 10.1016/j.ejmech.2016.09.052
Homo sapiens Acetylcholinesterase Inhibition 97.0 % 10.1016/j.ejmech.2019.111596
Homo sapiens Acetylcholinesterase Inhibition 98.0 % 10.1016/j.ejmech.2018.10.064
Homo sapiens Acetylcholinesterase Inhibition nan % 10.1016/j.bmcl.2018.07.019
Homo sapiens Acetylcholinesterase Inhibition nan % 10.1016/j.bmcl.2021.128205
Homo sapiens Acetylcholinesterase Inhibition nan % 10.1016/j.ejmech.2014.09.081
Homo sapiens Acetylcholinesterase Inhibition nan % 10.1016/j.ejmech.2021.113224
Homo sapiens Acetylcholinesterase Inhibition nan % 10.1016/j.ejmech.2022.114305
Homo sapiens Acetylcholinesterase K 0.02914 /s 10.1021/acs.jmedchem.0c01863
Homo sapiens Acetylcholinesterase K 3.64 /M/s 10.1021/acs.jmedchem.0c01863
Homo sapiens Acetylcholinesterase Kd 8.0 nM 10.1021/acs.jmedchem.0c01863
Homo sapiens Acetylcholinesterase Ki 7.2 nM 10.1016/j.bmcl.2012.11.100
Homo sapiens Acetylcholinesterase Ki 10.0 nM 10.1021/acsmedchemlett.5b00483
Homo sapiens Acetylcholinesterase Ki 12.7 nM 10.1021/acsmedchemlett.9b00656
Homo sapiens Acetylcholinesterase Ki 20.5 nM 10.1021/jm0340602
Homo sapiens Acetylcholinesterase Ki 20.5 nM 10.1021/jm0494366
Homo sapiens Acetylcholinesterase Ki 20.5 nM 10.1021/jm100293f
Homo sapiens Acetylcholinesterase Ki 38.0 nM 10.1016/j.ejmech.2018.08.005
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase IC50 100000.0 nM 10.1016/j.bmc.2016.01.031
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 3250.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 3791.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 4436.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10447.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 15901.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 6196.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Amyloid-beta A4 protein Activity 0.26 % 10.1016/j.ejmech.2017.10.017
Homo sapiens Amyloid-beta A4 protein Activity 1.58 % 10.1016/j.ejmech.2017.10.017
Homo sapiens Amyloid-beta A4 protein Activity 2.0 % 10.1016/j.ejmech.2017.10.017
Homo sapiens Amyloid-beta A4 protein Activity 81.0 % 10.1016/j.ejmech.2017.10.017
Homo sapiens Amyloid-beta A4 protein Activity 83.4 % 10.1039/C9MD00030E
Homo sapiens Amyloid-beta A4 protein Activity 96.16 % 10.1016/j.ejmech.2017.10.017
Homo sapiens Amyloid-beta A4 protein Activity nan None 10.1016/j.ejmech.2017.02.039
Homo sapiens Amyloid-beta A4 protein Activity nan None 10.1016/j.ejmech.2019.111958
Homo sapiens Amyloid-beta A4 protein Flu intensity 0.31 None 10.1016/j.ejmech.2019.111707
Homo sapiens Amyloid-beta A4 protein IC50 1593000.0 nM 10.1016/j.ejmech.2022.114841
Homo sapiens Amyloid-beta A4 protein IC50 nan None 10.1016/j.bmcl.2020.127659
Homo sapiens Amyloid-beta A4 protein IC50 nan None 10.1016/j.ejmech.2021.113310
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.bmc.2015.01.042
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.bmc.2018.01.030
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.bmc.2018.02.037
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.bmc.2019.01.040
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.bmc.2020.115400
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.ejmech.2014.02.045
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.ejmech.2015.02.063
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.ejmech.2017.02.039
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.ejmech.2017.04.054
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.ejmech.2018.01.055
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.ejmech.2019.07.021
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1016/j.ejmech.2019.111737
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1021/jm070559a
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1021/jm8009684
Homo sapiens Amyloid-beta A4 protein Inhibition 10.0 % 10.1016/j.ejmech.2016.07.052
Homo sapiens Amyloid-beta A4 protein Inhibition 13.8 % 10.1016/j.bmc.2015.03.051
Homo sapiens Amyloid-beta A4 protein Inhibition 13.8 % 10.1016/j.ejmech.2015.01.027
Homo sapiens Amyloid-beta A4 protein Inhibition 13.8 % 10.1016/j.ejmech.2016.09.078
Homo sapiens Amyloid-beta A4 protein Inhibition 14.5 % 10.1016/j.bmc.2016.04.015
Homo sapiens Amyloid-beta A4 protein Inhibition 15.4 % 10.1016/j.ejmech.2017.07.072
Homo sapiens Amyloid-beta A4 protein Inhibition 16.4 % 10.1016/j.bmc.2018.08.035
Homo sapiens Amyloid-beta A4 protein Inhibition 16.4 % 10.1016/j.ejmech.2018.05.031
Homo sapiens Amyloid-beta A4 protein Inhibition 16.7 % 10.1016/j.ejmech.2019.02.030
Homo sapiens Amyloid-beta A4 protein Inhibition 22.0 % 10.1016/j.ejmech.2018.04.058
Homo sapiens Amyloid-beta A4 protein Inhibition 22.8 % 10.1016/j.ejmech.2017.04.064
Homo sapiens Amyloid-beta A4 protein Inhibition 27.65 % 10.1016/j.ejmech.2021.114044
Homo sapiens Amyloid-beta A4 protein Inhibition 28.7 % 10.1016/j.ejmech.2018.08.005
Homo sapiens Amyloid-beta A4 protein Inhibition 31.0 % 10.1016/j.bmc.2020.115721
Homo sapiens Amyloid-beta A4 protein Inhibition 32.13 % 10.1016/j.ejmech.2021.113973
Homo sapiens Amyloid-beta A4 protein Inhibition 33.7 % 10.1016/j.ejmech.2017.02.042
Homo sapiens Amyloid-beta A4 protein Inhibition 33.78 % 10.1016/j.ejmech.2019.05.055
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2016.06.027
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2016.07.025
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2018.06.018
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2020.115940
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2023.117178
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmcl.2015.10.051
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmcl.2016.02.079
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2016.04.053
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2017.02.042
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2017.07.077
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2019.05.055
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2019.111958
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2021.113224
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2021.113541
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2021.113779
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2022.114841
Homo sapiens Amyloid-beta A4 protein Survival 96.0 % 10.1016/j.ejmech.2017.10.017
Homo sapiens Anandamide amidohydrolase IC50 nan None 10.1016/j.ejmech.2022.114358
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-secretase 1 IC50 18.0 nM 10.1016/j.ejmech.2021.113492
Homo sapiens Beta-secretase 1 IC50 169.0 nM 10.1016/j.ejmech.2017.07.006
Homo sapiens Beta-secretase 1 IC50 240.0 nM 10.1016/j.ejmech.2019.02.030
Homo sapiens Beta-secretase 1 IC50 362.0 nM 10.1016/j.bmc.2020.115721
Homo sapiens Beta-secretase 1 IC50 362.0 nM 10.1016/j.ejmech.2019.111707
Homo sapiens Beta-secretase 1 IC50 3200.0 nM 10.1016/j.bmcl.2012.05.077
Homo sapiens Beta-secretase 1 IC50 nan None 10.1016/j.ejmech.2019.111916
Homo sapiens Beta-secretase 1 IC50 nan None 10.1016/j.ejmech.2021.113397
Homo sapiens Beta-secretase 1 IC50 nan None 10.1016/j.ejmech.2021.113779
Homo sapiens Beta-secretase 1 Inhibition 50.0 % 10.1016/j.bmc.2008.12.067
Homo sapiens Beta-secretase 1 Inhibition 79.86 % 10.1016/j.ejmech.2017.07.006
Homo sapiens Beta-secretase 1 Inhibition nan % 10.1016/j.bmc.2011.09.061
Homo sapiens Beta-secretase 1 Inhibition nan % 10.1016/j.ejmech.2016.09.078
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 78000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 145600.0 nM 10.1124/dmd.112.047068
Homo sapiens Bile salt export pump IC50 205700.0 nM 10.1124/dmd.111.040758
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Butyrylcholinesterase Activity 47.9 % 10.1016/j.ejmech.2020.112265
Homo sapiens Butyrylcholinesterase Activity 49.6 % 10.1016/j.ejmech.2019.111958
Homo sapiens Butyrylcholinesterase Activity 49.6 % 10.1016/j.ejmech.2020.112180
Homo sapiens Butyrylcholinesterase Activity 50.9 % 10.1016/j.ejmech.2019.111958
Homo sapiens Butyrylcholinesterase Activity 50.9 % 10.1016/j.ejmech.2020.112180
Homo sapiens Butyrylcholinesterase Activity 51.6 % 10.1016/j.ejmech.2020.112265
Homo sapiens Butyrylcholinesterase Activity 60.3 % 10.1016/j.ejmech.2019.111958
Homo sapiens Butyrylcholinesterase Activity 60.3 % 10.1016/j.ejmech.2020.112180
Homo sapiens Butyrylcholinesterase Activity 63.2 % 10.1016/j.ejmech.2020.112265
Homo sapiens Butyrylcholinesterase Activity 98.1 % 10.1016/j.ejmech.2020.112265
Homo sapiens Butyrylcholinesterase Activity 102.1 % 10.1016/j.ejmech.2019.111958
Homo sapiens Butyrylcholinesterase IC50 14.0 nM 10.1016/j.bmc.2019.01.025
Homo sapiens Butyrylcholinesterase IC50 20.0 nM 10.1016/j.bmc.2014.08.026
Homo sapiens Butyrylcholinesterase IC50 117.0 nM 10.1016/j.ejmech.2021.113541
Homo sapiens Butyrylcholinesterase IC50 130.0 nM 10.1016/j.bmc.2016.10.016
Homo sapiens Butyrylcholinesterase IC50 930.0 nM 10.1021/jm8001313
Homo sapiens Butyrylcholinesterase IC50 1210.0 nM 10.1016/j.ejmech.2021.113224
Homo sapiens Butyrylcholinesterase IC50 1400.0 nM 10.1016/j.ejmech.2019.02.030
Homo sapiens Butyrylcholinesterase IC50 2000.0 nM 10.1016/j.bmc.2012.10.045
Homo sapiens Butyrylcholinesterase IC50 2420.0 nM 10.1016/j.bmc.2020.115721
Homo sapiens Butyrylcholinesterase IC50 2420.0 nM 10.1016/j.ejmech.2019.111707
Homo sapiens Butyrylcholinesterase IC50 2500.0 nM 10.1016/j.ejmech.2012.09.030
Homo sapiens Butyrylcholinesterase IC50 2500.0 nM 10.1016/j.ejmech.2013.06.021
Homo sapiens Butyrylcholinesterase IC50 2500.0 nM 10.1016/j.ejmech.2016.05.055
Homo sapiens Butyrylcholinesterase IC50 2500.0 nM 10.1016/j.ejmech.2017.02.034
Homo sapiens Butyrylcholinesterase IC50 2500.0 nM 10.1016/j.ejmech.2018.07.026
Homo sapiens Butyrylcholinesterase IC50 2500.0 nM 10.1016/j.ejmech.2018.07.056
Homo sapiens Butyrylcholinesterase IC50 2580.0 nM 10.1016/j.ejmech.2022.114152
Homo sapiens Butyrylcholinesterase IC50 2740.0 nM 10.1016/j.bmc.2016.02.023
Homo sapiens Butyrylcholinesterase IC50 2900.0 nM 10.1021/acsmedchemlett.9b00656
Homo sapiens Butyrylcholinesterase IC50 2900.0 nM 10.1021/jm00007a005
Homo sapiens Butyrylcholinesterase IC50 3130.0 nM 10.1016/j.ejmech.2022.114242
Homo sapiens Butyrylcholinesterase IC50 3170.0 nM 10.1016/j.ejmech.2016.07.052
Homo sapiens Butyrylcholinesterase IC50 3170.0 nM 10.1016/j.ejmech.2018.08.005
Homo sapiens Butyrylcholinesterase IC50 3200.0 nM 10.1016/j.ejmech.2017.02.039
Homo sapiens Butyrylcholinesterase IC50 3200.0 nM 10.1016/j.ejmech.2019.111958
Homo sapiens Butyrylcholinesterase IC50 3600.0 nM 10.1039/C5MD00274E
Homo sapiens Butyrylcholinesterase IC50 3900.0 nM 10.1021/jm101299d
Homo sapiens Butyrylcholinesterase IC50 4150.0 nM 10.1016/j.ejmech.2018.07.033
Homo sapiens Butyrylcholinesterase IC50 4150.0 nM 10.1021/jm010491d
Homo sapiens Butyrylcholinesterase IC50 4150.0 nM 10.1021/jm049309+
Homo sapiens Butyrylcholinesterase IC50 4150.0 nM 10.1021/jm050578p
Homo sapiens Butyrylcholinesterase IC50 4220.0 nM 10.1016/j.ejmech.2018.01.055
Homo sapiens Butyrylcholinesterase IC50 4260.0 nM 10.1016/j.bmcl.2022.128602
Homo sapiens Butyrylcholinesterase IC50 4380.0 nM 10.1016/j.ejmech.2017.07.077
Homo sapiens Butyrylcholinesterase IC50 4530.0 nM 10.1016/j.bmcl.2022.128976
Homo sapiens Butyrylcholinesterase IC50 4760.0 nM 10.1016/j.bmc.2016.07.025
Homo sapiens Butyrylcholinesterase IC50 4760.0 nM 10.1016/j.bmcl.2017.09.055
Homo sapiens Butyrylcholinesterase IC50 4786.3 nM 10.1016/j.bmc.2019.02.031
Homo sapiens Butyrylcholinesterase IC50 4800.0 nM 10.1016/j.bmc.2023.117256
Homo sapiens Butyrylcholinesterase IC50 4800.0 nM 10.1016/j.ejmech.2019.05.062
Homo sapiens Butyrylcholinesterase IC50 4800.0 nM 10.1016/j.ejmech.2022.114358
Homo sapiens Butyrylcholinesterase IC50 4800.0 nM 10.1021/acs.jmedchem.5b00599
Homo sapiens Butyrylcholinesterase IC50 4800.0 nM 10.1039/d2md00042c
Homo sapiens Butyrylcholinesterase IC50 5000.0 nM 10.1016/j.ejmech.2017.02.042
Homo sapiens Butyrylcholinesterase IC50 5120.0 nM 10.1016/j.ejmech.2019.111737
Homo sapiens Butyrylcholinesterase IC50 5400.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens Butyrylcholinesterase IC50 5580.0 nM 10.1039/C7MD00199A
Homo sapiens Butyrylcholinesterase IC50 5600.0 nM 10.1016/j.ejmech.2015.08.052
Homo sapiens Butyrylcholinesterase IC50 6370.0 nM 10.1016/j.ejmech.2014.03.015
Homo sapiens Butyrylcholinesterase IC50 6370.0 nM 10.1016/j.ejmech.2014.03.046
Homo sapiens Butyrylcholinesterase IC50 6400.0 nM 10.1016/j.ejmech.2020.113124
Homo sapiens Butyrylcholinesterase IC50 6500.0 nM 10.1016/j.ejmech.2021.113964
Homo sapiens Butyrylcholinesterase IC50 6920.0 nM 10.1016/j.ejmech.2014.06.034
Homo sapiens Butyrylcholinesterase IC50 6980.0 nM 10.1016/j.ejmech.2021.113779
Homo sapiens Butyrylcholinesterase IC50 7000.0 nM 10.1016/j.bmcl.2010.12.041
Homo sapiens Butyrylcholinesterase IC50 7100.0 nM 10.1016/j.bmc.2014.08.016
Homo sapiens Butyrylcholinesterase IC50 7300.0 nM 10.1016/j.bmc.2020.115940
Homo sapiens Butyrylcholinesterase IC50 7400.0 nM 10.1016/j.ejmech.2011.02.019
Homo sapiens Butyrylcholinesterase IC50 7420.0 nM 10.1016/j.bmc.2010.01.071
Homo sapiens Butyrylcholinesterase IC50 7420.0 nM 10.1016/j.ejmech.2008.02.035
Homo sapiens Butyrylcholinesterase IC50 7420.0 nM 10.1021/jm0340602
Homo sapiens Butyrylcholinesterase IC50 7420.0 nM 10.1021/jm070559a
Homo sapiens Butyrylcholinesterase IC50 7420.0 nM 10.1021/jm8009684
Homo sapiens Butyrylcholinesterase IC50 7500.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Butyrylcholinesterase IC50 7585.78 nM 10.1021/jm0494366
Homo sapiens Butyrylcholinesterase IC50 7600.0 nM 10.1016/j.bmc.2016.01.031
Homo sapiens Butyrylcholinesterase IC50 7600.0 nM 10.1016/j.ejmech.2020.112180
Homo sapiens Butyrylcholinesterase IC50 8200.0 nM 10.1021/jm001088u
Homo sapiens Butyrylcholinesterase IC50 8200.0 nM 10.1021/jm501501a
Homo sapiens Butyrylcholinesterase IC50 8200.0 nM 10.1021/jm981101z
Homo sapiens Butyrylcholinesterase IC50 8280.0 nM 10.1039/C6MD00053C
Homo sapiens Butyrylcholinesterase IC50 8700.0 nM 10.1016/j.ejmech.2017.07.055
Homo sapiens Butyrylcholinesterase IC50 9140.0 nM 10.1016/j.bmc.2018.12.030
Homo sapiens Butyrylcholinesterase IC50 9140.0 nM 10.1016/j.ejmech.2017.08.051
Homo sapiens Butyrylcholinesterase IC50 9140.0 nM 10.1016/j.ejmech.2018.01.007
Homo sapiens Butyrylcholinesterase IC50 10050.0 nM 10.1016/j.bmc.2007.07.003
Homo sapiens Butyrylcholinesterase IC50 10240.0 nM 10.1016/j.bmc.2019.07.001
Homo sapiens Butyrylcholinesterase IC50 10660.0 nM 10.1021/acs.jmedchem.2c01003
Homo sapiens Butyrylcholinesterase IC50 11860.0 nM 10.1016/j.ejmech.2021.113735
Homo sapiens Butyrylcholinesterase IC50 13600.0 nM 10.1016/j.bmcl.2013.05.092
Homo sapiens Butyrylcholinesterase IC50 14400.0 nM 10.1016/j.ejmech.2020.112140
Homo sapiens Butyrylcholinesterase IC50 15240.0 nM 10.1016/j.bmc.2013.06.003
Homo sapiens Butyrylcholinesterase IC50 15240.0 nM 10.1016/j.bmcl.2013.03.026
Homo sapiens Butyrylcholinesterase IC50 15240.0 nM 10.1016/j.ejmech.2018.11.049
Homo sapiens Butyrylcholinesterase IC50 nan None 10.1016/j.bmcl.2020.127659
Homo sapiens Butyrylcholinesterase IC50 nan None 10.1016/j.ejmech.2017.10.006
Homo sapiens Butyrylcholinesterase IC50 nan None 10.1016/j.ejmech.2020.112743
Homo sapiens Butyrylcholinesterase IC50 nan None 10.1016/j.ejmech.2021.113397
Homo sapiens Butyrylcholinesterase Inhibition 0.06 % 10.1016/j.bmcl.2022.128602
Homo sapiens Butyrylcholinesterase Inhibition 8.21 % 10.1016/j.ejmech.2017.10.006
Homo sapiens Butyrylcholinesterase Inhibition 14.78 % 10.1016/j.ejmech.2016.09.052
Homo sapiens Butyrylcholinesterase Inhibition 25.2 % 10.1016/j.ejmech.2018.05.031
Homo sapiens Butyrylcholinesterase Inhibition 29.3 % 10.1016/j.ejmech.2017.02.042
Homo sapiens Butyrylcholinesterase Inhibition 44.56 % 10.1016/j.ejmech.2016.09.052
Homo sapiens Butyrylcholinesterase Inhibition 50.0 % 10.1016/j.ejmech.2021.113792
Homo sapiens Butyrylcholinesterase Ki 12540.0 nM 10.1016/j.bmc.2013.06.003
Homo sapiens Caco-2 permeability 55.51 nm/s 10.1016/j.ejmech.2014.04.078
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholinesterases; ACHE & BCHE IC50 ratio 510.0 None 10.1021/jm001088u
Homo sapiens Cholinesterases; ACHE & BCHE Ratio 360.0 None 10.1021/jm00043a012
Homo sapiens Cholinesterases; ACHE & BCHE Ratio 1252.0 None 10.1016/S0960-894X(00)80547-8
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 0.003 None 10.1016/j.ejmech.2017.09.022
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 39.7 None 10.1016/j.bmc.2016.07.025
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 43.8 None 10.1016/j.ejmech.2017.07.077
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 57.6 None 10.1016/j.bmc.2020.115721
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 57.6 None 10.1016/j.ejmech.2019.111707
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 188.0 None 10.1021/jm050578p
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 250.0 None 10.1016/j.ejmech.2012.09.030
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 251.0 None 10.1016/j.bmcl.2017.09.055
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 256.0 None 10.1016/j.bmc.2019.07.001
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 291.0 None 10.1016/j.ejmech.2019.111958
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 321.0 None 10.1016/j.ejmech.2011.02.019
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 371.0 None 10.1016/j.ejmech.2008.02.035
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 844.4 None 10.1016/j.ejmech.2020.112180
Homo sapiens Cholinesterases; ACHE & BCHE Ratio pIC50 331.0 None 10.1021/jm0494366
Homo sapiens Cholinesterases; ACHE & BCHE Selectivity 188.0 None 10.1021/jm010491d
Homo sapiens Cholinesterases; ACHE & BCHE Selectivity Index 32.36 None 10.1016/j.bmc.2019.02.031
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 1A2 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2B6 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C8 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C9 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 IC50 54680.0 nM 10.1016/j.bmcl.2014.11.046
Homo sapiens Cytochrome P450 3A4 Inhibition 8.1 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Cytochrome P450 3A4 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 3A4 Inhibition 22.2 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Cytochrome P450 3A4 Inhibition 27.0 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Cytochrome P450 3A4 Inhibition 68.4 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Cytochrome P450 3A4 Inhibition 83.9 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Cytochrome P450 3A4 Inhibition 87.3 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor AC50 824.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 9776.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition nan % 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Inhibition nan % 10.1021/jm301034u
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 37585.7 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A Inhibition 50.0 % 10.1016/j.bmc.2021.116355
Homo sapiens Glycogen synthase kinase-3 beta IC50 1000.0 nM 10.1016/j.bmc.2020.115940
Homo sapiens Glycogen synthase kinase-3 beta IC50 10000.0 nM 10.1016/j.ejmech.2021.113663
Homo sapiens Glycogen synthase kinase-3 beta IC50 100000.0 nM 10.1021/acs.jmedchem.1c00160
Homo sapiens Glycogen synthase kinase-3 beta IC50 nan None 10.1016/j.ejmech.2021.114095
Homo sapiens HEK293 IC50 200000.0 nM 10.1016/j.ejmech.2020.112368
Homo sapiens HepG2 Activity 40.9 % 10.1016/j.ejmech.2014.04.078
Homo sapiens HepG2 Activity 53.4 % 10.1016/j.ejmech.2014.04.078
Homo sapiens HepG2 Activity 80.0 % 10.1016/j.ejmech.2014.04.078
Homo sapiens HepG2 Activity 83.5 % 10.1016/j.ejmech.2014.04.078
Homo sapiens HepG2 Activity 90.0 % 10.1016/j.ejmech.2018.01.066
Homo sapiens HepG2 Activity 91.1 % 10.1016/j.ejmech.2021.113735
Homo sapiens HepG2 Activity 92.4 % 10.1016/j.ejmech.2014.04.078
Homo sapiens HepG2 Activity 97.0 % 10.1016/j.ejmech.2014.04.078
Homo sapiens HepG2 Activity 98.6 % 10.1016/j.ejmech.2014.04.078
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2017.08.051
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2021.113735
Homo sapiens HepG2 Activity_index 24.0 None 10.1016/j.ejmech.2018.01.066
Homo sapiens HepG2 IC50 262727.0 nM 10.1016/j.ejmech.2021.113827
Homo sapiens HepG2 IC50 nan None 10.1016/j.bmcl.2021.128306
Homo sapiens HepG2 IC50 nan None 10.1016/j.ejmech.2018.01.066
Homo sapiens HERG AC50 2220.4 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 640.0 nM 10.1016/j.ejmech.2021.114045
Homo sapiens HERG IC50 1995.26 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 8718.0 nM 10.1016/j.ejmech.2021.113827
Homo sapiens HFF IC50 91.0 nM 10.1016/j.ejmech.2020.112140
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 2500.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 5204.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor IC50 350.0 nM 10.1016/j.bmc.2007.12.048
Homo sapiens Histamine H3 receptor IC50 nan None 10.1016/j.bmc.2011.09.061
Homo sapiens Histamine H3 receptor IC50 nan None 10.1016/j.ejmech.2019.02.053
Homo sapiens Histamine H3 receptor Inhibition nan % 10.1016/j.bmc.2011.09.061
Homo sapiens Histamine H3 receptor Inhibition nan % 10.1016/j.ejmech.2019.02.053
Homo sapiens Histamine H3 receptor Ki nan None 10.1016/j.bmcl.2016.04.054
Homo sapiens Histamine H3 receptor Ki nan None 10.1016/j.ejmech.2019.111785
Homo sapiens Histone deacetylase 6 Inhibition -2.55 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 4.56 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 6309.6 nM None
Homo sapiens Homo sapiens AUC 3702.02 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens Css 0.406 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 92.0 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Homo sapiens F 100.0 % 10.1016/j.ejmech.2016.10.036
Homo sapiens Homo sapiens T1/2 70.0 hr 10.1016/j.ejmech.2016.10.036
Homo sapiens IMR-32 Activity 82.6 % 10.1016/j.bmc.2007.07.003
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Liver microsome CLH nan None 10.1124/dmd.111.039180
Homo sapiens Liver microsome Drug metabolism nan None 10.1124/dmd.111.039180
Homo sapiens Liver microsome PB 29.7 pmol 10.1124/dmd.111.039180
Homo sapiens Liver microsomes Activity 30.0 pmol 10.1021/tx300075j
Homo sapiens MCF7 IC50 60.0 nM 10.1016/j.ejmech.2020.112140
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Microtubule-associated protein tau Inhibition nan % 10.1016/j.ejmech.2021.113779
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 850000.0 nM 10.1016/j.ejmech.2013.12.028
Homo sapiens Monoamine oxidase A IC50 1000000.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Monoamine oxidase A IC50 nan None 10.1016/j.bmcl.2017.09.057
Homo sapiens Monoamine oxidase A IC50 nan None 10.1016/j.ejmech.2016.05.055
Homo sapiens Monoamine oxidase A IC50 nan None 10.1016/j.ejmech.2016.09.041
Homo sapiens Monoamine oxidase A IC50 nan None 10.1016/j.ejmech.2019.05.039
Homo sapiens Monoamine oxidase A IC50 nan None 10.1016/j.ejmech.2019.07.021
Homo sapiens Monoamine oxidase A IC50 nan None 10.1016/j.ejmech.2019.111737
Homo sapiens Monoamine oxidase A IC50 nan None 10.1021/acs.jmedchem.1c01784
Homo sapiens Monoamine oxidase A IC50 nan None 10.1021/jm501501a
Homo sapiens Monoamine oxidase A IC50 nan None 10.1039/C7MD00199A
Homo sapiens Monoamine oxidase A IC50 nan None 10.1039/c9md00441f
Homo sapiens Monoamine oxidase A Inhibition 0.0 % 10.1021/acs.jmedchem.5b00599
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1016/j.bmc.2018.01.030
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1016/j.bmc.2020.115400
Homo sapiens Monoamine oxidase B IC50 15000.0 nM 10.1016/j.ejmech.2013.12.028
Homo sapiens Monoamine oxidase B IC50 15200.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Monoamine oxidase B IC50 23000.0 nM 10.1016/j.ejmech.2022.114242
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.bmcl.2017.09.057
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.bmcl.2019.126625
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2016.05.055
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2016.09.041
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2019.05.039
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2019.07.021
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2019.111737
Homo sapiens Monoamine oxidase B IC50 nan None 10.1021/acs.jmedchem.1c01784
Homo sapiens Monoamine oxidase B IC50 nan None 10.1021/jm501501a
Homo sapiens Monoamine oxidase B IC50 nan None 10.1039/C7MD00199A
Homo sapiens Monoamine oxidase B IC50 nan None 10.1039/c9md00441f
Homo sapiens Monoamine oxidase B Inhibition 0.0 % 10.1021/acs.jmedchem.5b00599
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.bmc.2018.01.030
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.bmc.2020.115400
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 72900.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 5321.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 8199.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 1113.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 2666.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 pKb nan None 10.1021/jm0494366
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M5 AC50 15391.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 6100.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 9129.1 nM 10.1038/s41467-023-40064-9
Homo sapiens PBMC IC50 nan None 10.1016/j.ejmech.2018.01.066
Homo sapiens P-glycoprotein 1 IC50 34850.0 nM 10.1016/j.bmcl.2014.11.046
Homo sapiens P-glycoprotein 1 Inhibition 15.0 % 10.1016/j.bmcl.2014.11.046
Homo sapiens P-glycoprotein 1 Inhibition 17.8 % 10.1016/j.bmcl.2014.11.046
Homo sapiens P-glycoprotein 1 Inhibition 23.5 % 10.1016/j.bmcl.2014.11.046
Homo sapiens P-glycoprotein 1 Inhibition 76.0 % 10.1016/j.bmcl.2014.11.046
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D IC50 36000.0 nM 10.1016/j.ejmech.2022.114503
Homo sapiens Phosphodiesterase 5A IC50 100000.0 nM 10.1016/j.bmcl.2020.127097
Homo sapiens Plasma fCmax 0.002 uM 10.1124/dmd.111.040758
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 8206.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 4 (5-HT4) receptor Inhibition 10.0 % 10.1016/j.ejmech.2018.10.064
Homo sapiens Serotonin 4 (5-HT4) receptor Ki nan None 10.1016/j.ejmech.2018.10.064
Homo sapiens Serotonin 6 (5-HT6) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 7 (5-HT7) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 1000000.0 nM 10.1016/j.ejmech.2020.112368
Homo sapiens SH-SY5Y Activity 33.0 % 10.1016/j.ejmech.2017.08.051
Homo sapiens SH-SY5Y Activity 33.0 % 10.1016/j.ejmech.2018.04.058
Homo sapiens SH-SY5Y Activity 38.4 % 10.1016/j.ejmech.2018.07.026
Homo sapiens SH-SY5Y Activity 39.3 % 10.1016/j.bmcl.2020.127370
Homo sapiens SH-SY5Y Activity 39.9 % 10.1016/j.ejmech.2018.04.058
Homo sapiens SH-SY5Y Activity 45.0 % 10.1021/acs.jmedchem.0c00756
Homo sapiens SH-SY5Y Activity 48.2 % 10.1021/acs.jmedchem.6b00426
Homo sapiens SH-SY5Y Activity 50.0 % 10.1016/j.ejmech.2017.02.043
Homo sapiens SH-SY5Y Activity 60.82 % 10.1016/j.ejmech.2021.113541
Homo sapiens SH-SY5Y Activity 62.0 % 10.1021/acs.jmedchem.6b00426
Homo sapiens SH-SY5Y Activity 62.5 % 10.1039/C9MD00030E
Homo sapiens SH-SY5Y Activity 64.4 % 10.1016/j.ejmech.2018.09.010
Homo sapiens SH-SY5Y Activity 69.0 % 10.1039/C9MD00030E
Homo sapiens SH-SY5Y Activity 80.4 % 10.1016/j.ejmech.2018.09.010
Homo sapiens SH-SY5Y Activity 92.3 % 10.1021/acs.jmedchem.6b00426
Homo sapiens SH-SY5Y Activity 94.3 % 10.1016/j.ejmech.2018.09.010
Homo sapiens SH-SY5Y Activity 94.7 % 10.1016/j.ejmech.2018.09.010
Homo sapiens SH-SY5Y Activity 96.9 % 10.1021/acs.jmedchem.6b00426
Homo sapiens SH-SY5Y Activity 99.3 % 10.1016/j.ejmech.2018.09.010
Homo sapiens SH-SY5Y Activity 100.0 % 10.1016/j.ejmech.2018.09.010
Homo sapiens SH-SY5Y Activity 101.11 % 10.1016/j.ejmech.2021.113541
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.bmc.2020.115940
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.bmcl.2020.127477
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2017.08.051
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2018.09.010
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2018.10.016
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2019.02.053
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2019.111613
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2022.114305
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2022.114841
Homo sapiens SH-SY5Y Activity nan None 10.1021/acsmedchemlett.5b00483
Homo sapiens SH-SY5Y CC50 25060.0 nM 10.1016/j.ejmech.2019.02.053
Homo sapiens SH-SY5Y IC50 300.0 nM 10.1016/j.ejmech.2020.112140
Homo sapiens SH-SY5Y IC50 15540.0 nM 10.1016/j.ejmech.2016.10.036
Homo sapiens SH-SY5Y IC50 35000.0 nM 10.1016/j.ejmech.2022.114841
Homo sapiens SH-SY5Y IC50 84100.0 nM 10.1016/j.bmc.2019.02.031
Homo sapiens SH-SY5Y IC50 95130.0 nM 10.1016/j.ejmech.2019.06.088
Homo sapiens SH-SY5Y IC50 155000.0 nM 10.1016/j.ejmech.2022.114841
Homo sapiens SH-SY5Y IC50 200000.0 nM 10.1016/j.ejmech.2020.112368
Homo sapiens SH-SY5Y IC50 202000.0 nM 10.1016/j.ejmech.2022.114841
Homo sapiens SH-SY5Y IC50 326000.0 nM 10.1016/j.ejmech.2022.114841
Homo sapiens SH-SY5Y IC50 nan None 10.1016/j.ejmech.2017.02.043
Homo sapiens SH-SY5Y IC50 nan None 10.1016/j.ejmech.2018.01.066
Homo sapiens SH-SY5Y MNCC 100.0 uM 10.1016/j.ejmech.2022.114305
Homo sapiens SH-SY5Y Survival nan None 10.1016/j.ejmech.2017.02.034
Homo sapiens Sigma opioid receptor Ki 14.6 nM 10.1016/j.bmc.2013.03.016
Homo sapiens Sigma opioid receptor Ki 14.6 nM 10.1021/acs.jmedchem.0c01192
Homo sapiens Sigma opioid receptor Ki nan None 10.1016/j.ejmech.2018.10.064
Homo sapiens SK-N-MC Activity 74.0 % 10.1016/j.ejmech.2017.08.021
Homo sapiens SK-N-MC Activity nan None 10.1016/j.ejmech.2017.08.021
Homo sapiens SK-N-MC IC50 100000.0 nM 10.1016/j.ejmech.2017.08.021
Homo sapiens Sodium channel protein type V alpha subunit AC50 50000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Sphingomyelin phosphodiesterase Activity 118.8 % 10.1021/jm070524a
Homo sapiens THP-1 Activity nan None 10.1016/j.ejmech.2020.113124
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 15560.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel IC50 34300.0 nM 10.1038/srep02100
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit AC50 50000.0 nM 10.1038/s41467-023-40064-9
Macaca fascicularis Brain Fu 0.134 None 10.1124/dmd.111.038778
Macaca mulatta Rhesus monkey Activity nan None 10.1021/acsmedchemlett.8b00214
Mus musculus Acetylcholinesterase IC50 5.4 nM 10.1016/j.ejmech.2022.114305
Mus musculus Acetylcholinesterase IC50 5.7 nM 10.1021/acs.jmedchem.7b01086
Mus musculus Acetylcholinesterase IC50 6.22 nM 10.1016/j.ejmech.2021.114045
Mus musculus Acetylcholinesterase IC50 11.9 nM 10.1016/j.bmcl.2019.04.051
Mus musculus Acetylcholinesterase IC50 84.0 nM 10.1016/j.ejmech.2019.02.053
Mus musculus Acetylcholinesterase IC50 94.0 nM None
Mus musculus Acetylcholinesterase IC50 1820.0 nM 10.1016/j.bmc.2016.07.061
Mus musculus Acetylcholinesterase IC50 6100.0 nM 10.1021/acs.jmedchem.1c00160
Mus musculus Acetylcholinesterase IC50 14550.0 nM 10.1016/j.bmc.2017.11.033
Mus musculus Acetylcholinesterase Inhibition 32.9 % 10.1016/j.ejmech.2021.113663
Mus musculus Acetylcholinesterase Inhibition 36.3 % 10.1016/j.ejmech.2021.113663
Mus musculus Acetylcholinesterase Inhibition 40.32 % 10.1016/j.bmc.2017.11.033
Mus musculus Acetylcholinesterase Inhibition 43.54 % 10.1016/j.bmc.2017.11.033
Mus musculus Acetylcholinesterase Inhibition 48.38 % 10.1016/j.bmc.2017.11.033
Mus musculus Acetylcholinesterase Inhibition 53.8 % 10.1016/j.ejmech.2021.113663
Mus musculus Acetylcholinesterase Inhibition 56.45 % 10.1016/j.bmc.2017.11.033
Mus musculus Acetylcholinesterase Inhibition 64.1 % 10.1016/j.ejmech.2021.113663
Mus musculus Acetylcholinesterase Inhibition 69.35 % 10.1016/j.bmc.2017.11.033
Mus musculus Acetylcholinesterase Inhibition 72.9 % 10.1016/j.ejmech.2021.113663
Mus musculus Acetylcholinesterase Inhibition 88.99 % 10.1016/j.ejmech.2019.02.053
Mus musculus Acetylcholinesterase Inhibition 1257.8 % 10.1016/j.ejmech.2021.113663
Mus musculus Acetylcholinesterase Inhibition nan % 10.1021/acs.jmedchem.0c01863
Mus musculus Brain Fu 0.1 None 10.1124/dmd.111.038778
Mus musculus Butyrylcholinesterase IC50 1992.0 nM 10.1016/j.ejmech.2021.114045
Mus musculus Butyrylcholinesterase IC50 7138.0 nM 10.1021/acs.jmedchem.7b01086
Mus musculus Butyrylcholinesterase IC50 nan None 10.1016/j.ejmech.2019.02.053
Mus musculus Butyrylcholinesterase Inhibition nan % 10.1016/j.ejmech.2019.02.053
Mus musculus BV-2 Activity nan None 10.1016/j.ejmech.2019.02.053
Mus musculus BV-2 Activity nan None 10.1016/j.ejmech.2021.114044
Mus musculus BV-2 Activity nan None 10.1016/j.ejmech.2022.114503
Mus musculus BV-2 IC50 1540.0 nM 10.1016/j.ejmech.2021.114044
Mus musculus BV-2 Inhibition nan % 10.1016/j.bmcl.2020.127193
Mus musculus BV-2 Inhibition nan % 10.1016/j.ejmech.2018.08.005
Mus musculus Dual specificity protein kinase CLK1 Inhibition nan % 10.1021/jm301034u
Mus musculus Dual specificity protein kinase CLK3 Inhibition nan % 10.1021/jm301034u
Mus musculus HT-22 IC50 56420.0 nM 10.1016/j.ejmech.2021.114044
Mus musculus Mus musculus Activity 0.26 nmol 10.1016/j.bmc.2016.07.061
Mus musculus Mus musculus Activity 0.82 nM/min/mg 10.1016/j.bmc.2017.09.012
Mus musculus Mus musculus Activity 0.89 U 10.1016/j.bmc.2016.07.061
Mus musculus Mus musculus Activity 1.75 None 10.1016/j.bmc.2022.117146
Mus musculus Mus musculus Activity 1.9 None 10.1016/j.ejmech.2008.03.003
Mus musculus Mus musculus Activity 7.95 m 10.1016/j.ejmech.2022.114841
Mus musculus Mus musculus Activity 18.13 nM/mg 10.1016/j.bmc.2017.09.012
Mus musculus Mus musculus Activity 24.08 % 10.1021/acs.jmedchem.0c01129
Mus musculus Mus musculus Activity 29.1 ug/mg 10.1016/j.ejmech.2021.114098
Mus musculus Mus musculus Activity 34.6 nM/mg 10.1016/j.bmc.2017.09.012
Mus musculus Mus musculus Activity 44.23 % 10.1016/j.ejmech.2022.114210
Mus musculus Mus musculus Activity 62.3 % 10.1016/j.ejmech.2018.11.037
Mus musculus Mus musculus Activity 65.23 % 10.1021/acs.jmedchem.0c01129
Mus musculus Mus musculus Activity 75.0 s 10.1016/j.ejmech.2008.03.003
Mus musculus Mus musculus Activity 134.42 % 10.1021/jm100573q
Mus musculus Mus musculus Activity 359.45 ug ml-1 10.1016/j.bmc.2016.07.061
Mus musculus Mus musculus Activity nan None 10.1007/s00044-012-0162-3
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2011.05.027
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2015.03.051
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2017.09.012
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2017.11.033
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2019.07.001
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2020.115400
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2020.115940
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2021.116074
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2016.11.070
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2014.02.045
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2014.04.078
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2015.02.063
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2016.07.052
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.02.078
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.08.005
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.11.037
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.11.049
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2019.111651
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2020.112257
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2021.113426
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2021.113663
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2021.113735
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2021.114044
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2021.114098
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2022.114210
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2022.114305
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2022.114503
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2022.114825
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2022.114841
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.0c00060
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.0c01129
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.0c01573
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.0c01863
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.5b00115
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.6b00426
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.8b00848
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.8b01041
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.9b00937
Mus musculus Mus musculus Activity nan None 10.1021/ml3001769
Mus musculus Mus musculus ED50 14.0 mg.kg-1 10.1021/jm00043a012
Mus musculus Mus musculus IC50 316420.0 nM 10.1016/j.bmcl.2016.10.041
Mus musculus Mus musculus Inhibition 19.0 % 10.1016/j.ejmech.2021.113735
Mus musculus Mus musculus Inhibition nan % 10.1016/j.ejmech.2018.11.049
Mus musculus Mus musculus LD50 22.5 mg.kg-1 10.1021/acs.jmedchem.7b00702
Mus musculus Mus musculus TIME 0.003156 hr 10.1016/j.bmc.2016.07.061
Mus musculus Mus musculus TIME 0.0032 hr 10.1016/j.bmc.2017.11.033
Mus musculus Mus musculus TIME 0.00425 hr 10.1021/acs.jmedchem.0c01129
Mus musculus Mus musculus TIME 0.004547 hr 10.1016/j.bmc.2021.116385
Mus musculus Mus musculus TIME 0.004908 hr 10.1016/j.bmc.2017.11.033
Mus musculus Mus musculus TIME 0.01052 hr 10.1016/j.ejmech.2022.114841
Mus musculus Mus musculus TIME 0.01461 hr 10.1007/s00044-012-0162-3
Mus musculus Mus musculus TIME 0.01461 hr 10.1016/j.bmc.2011.05.027
Mus musculus Mus musculus TIME 0.02033 hr 10.1016/j.ejmech.2017.02.039
Mus musculus Mus musculus TIME 0.02356 hr 10.1007/s00044-012-0162-3
Mus musculus Mus musculus TIME 0.02356 hr 10.1016/j.bmc.2011.05.027
Mus musculus Mus musculus TIME 0.03689 hr 10.1016/j.ejmech.2015.02.063
Mus musculus Mus musculus TIME 0.04083 hr 10.1016/j.bmc.2022.117146
Mus musculus Mus musculus TIME 0.04214 hr 10.1016/j.ejmech.2019.07.021
Mus musculus Mus musculus TIME 0.04347 hr 10.1016/j.ejmech.2019.111737
Mus musculus Mus musculus TIME 0.04883 hr 10.1016/j.ejmech.2017.02.039
Mus musculus Mus musculus TIME 0.05028 hr 10.1016/j.ejmech.2018.01.055
Mus musculus Mus musculus TIME 0.05658 hr 10.1016/j.ejmech.2017.04.054
Mus musculus Mus musculus TIME 0.05981 hr 10.1039/C7MD00199A
Mus musculus Mus musculus TIME 0.06984 hr 10.1016/j.ejmech.2020.112180
Plasmodium falciparum Plasmodium falciparum Potency 9528.3 nM None
Plasmodium falciparum Plasmodium falciparum Potency 10691.0 nM None
Rattus norvegicus Acetylcholinesterase Activity nan None 10.1016/S0960-894X(00)80547-8
Rattus norvegicus Acetylcholinesterase IC50 1.7 nM 10.1021/jm00015a020
Rattus norvegicus Acetylcholinesterase IC50 2.0 nM 10.1021/acs.jmedchem.0c01863
Rattus norvegicus Acetylcholinesterase IC50 5.0 nM 10.1016/j.bmc.2011.09.061
Rattus norvegicus Acetylcholinesterase IC50 5.7 nM 10.1016/S0960-894X(00)80547-8
Rattus norvegicus Acetylcholinesterase IC50 5.7 nM 10.1021/jm8001313
Rattus norvegicus Acetylcholinesterase IC50 7.86 nM 10.1016/j.bmc.2008.12.067
Rattus norvegicus Acetylcholinesterase IC50 10.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Acetylcholinesterase IC50 11.0 nM 10.1016/j.bmc.2014.07.009
Rattus norvegicus Acetylcholinesterase IC50 12.0 nM 10.1016/j.bmc.2009.07.072
Rattus norvegicus Acetylcholinesterase IC50 12.0 nM 10.1016/j.ejmech.2008.03.003
Rattus norvegicus Acetylcholinesterase IC50 12.7 nM 10.1016/j.bmc.2017.09.012
Rattus norvegicus Acetylcholinesterase IC50 15.0 nM 10.1016/j.bmc.2015.01.042
Rattus norvegicus Acetylcholinesterase IC50 15.0 nM 10.1016/j.bmc.2018.11.015
Rattus norvegicus Acetylcholinesterase IC50 15.0 nM 10.1016/j.ejmech.2014.02.045
Rattus norvegicus Acetylcholinesterase IC50 15.0 nM 10.1016/j.ejmech.2015.02.063
Rattus norvegicus Acetylcholinesterase IC50 15.0 nM 10.1016/j.ejmech.2017.04.054
Rattus norvegicus Acetylcholinesterase IC50 15.0 nM 10.1016/j.ejmech.2019.111958
Rattus norvegicus Acetylcholinesterase IC50 15.0 nM 10.1016/j.ejmech.2021.113310
Rattus norvegicus Acetylcholinesterase IC50 15.85 nM 10.1007/s00044-012-0227-3
Rattus norvegicus Acetylcholinesterase IC50 16.0 nM 10.1007/s00044-012-0227-3
Rattus norvegicus Acetylcholinesterase IC50 16.0 nM 10.1016/j.bmcl.2005.05.132
Rattus norvegicus Acetylcholinesterase IC50 19.0 nM 10.1016/j.ejmech.2016.12.009
Rattus norvegicus Acetylcholinesterase IC50 20.0 nM 10.1016/s0960-894x(99)00597-1
Rattus norvegicus Acetylcholinesterase IC50 21.5 nM 10.1007/s00044-012-0162-3
Rattus norvegicus Acetylcholinesterase IC50 21.5 nM 10.1016/j.bmc.2011.05.027
Rattus norvegicus Acetylcholinesterase IC50 26.8 nM 10.1016/j.bmc.2008.07.014
Rattus norvegicus Acetylcholinesterase IC50 32.0 nM 10.1016/j.bmc.2012.11.044
Rattus norvegicus Acetylcholinesterase IC50 35.48 nM 10.1016/j.bmc.2008.10.029
Rattus norvegicus Acetylcholinesterase IC50 37.0 nM 10.1016/j.bmc.2017.03.070
Rattus norvegicus Acetylcholinesterase IC50 37.0 nM 10.1016/j.bmcl.2017.09.055
Rattus norvegicus Acetylcholinesterase IC50 37.0 nM 10.1016/j.ejmech.2017.02.039
Rattus norvegicus Acetylcholinesterase IC50 40.0 nM 10.1016/j.ejmech.2007.04.018
Rattus norvegicus Acetylcholinesterase IC50 42.82 nM 10.1016/j.ejmech.2021.113827
Rattus norvegicus Acetylcholinesterase IC50 120.0 nM 10.1016/j.bmcl.2020.127404
Rattus norvegicus Acetylcholinesterase Inhibition 27.0 % 10.1016/j.bmcl.2019.126880
Rattus norvegicus Acetylcholinesterase Inhibition nan % 10.1021/jm00081a022
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Ratio IC50 119.0 None 10.1016/j.bmcl.2017.09.055
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Ratio IC50 231.0 None 10.1016/j.ejmech.2008.03.003
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Ratio IC50 298.0 None 10.1016/j.ejmech.2021.113827
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Ratio IC50 389.0 None 10.1016/j.bmc.2009.07.072
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Ratio IC50 1380.0 None 10.1016/j.ejmech.2019.111958
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Selectivity Index 1380.0 None 10.1016/j.ejmech.2021.113310
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Bile salt export pump IC50 519300.0 nM 10.1124/dmd.111.040758
Rattus norvegicus Brain Drug uptake 1.0 ug/kg 10.1021/acs.jmedchem.7b01086
Rattus norvegicus Brain Fu 0.07 None 10.1124/dmd.111.038778
Rattus norvegicus Brain Fu 0.111 None 10.1124/dmd.111.038778
Rattus norvegicus Butyrylcholinesterase IC50 1280.0 nM 10.1016/j.bmc.2014.07.009
Rattus norvegicus Butyrylcholinesterase IC50 2770.0 nM 10.1016/j.ejmech.2008.03.003
Rattus norvegicus Butyrylcholinesterase IC50 3260.0 nM 10.1016/j.bmc.2008.07.014
Rattus norvegicus Butyrylcholinesterase IC50 4420.0 nM 10.1016/j.bmcl.2017.09.055
Rattus norvegicus Butyrylcholinesterase IC50 4670.0 nM 10.1016/j.bmc.2009.07.072
Rattus norvegicus Butyrylcholinesterase IC50 5010.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Butyrylcholinesterase IC50 5300.0 nM 10.1016/j.ejmech.2007.04.018
Rattus norvegicus Butyrylcholinesterase IC50 7138.0 nM 10.1016/S0960-894X(00)80547-8
Rattus norvegicus Butyrylcholinesterase IC50 7138.0 nM 10.1021/jm8001313
Rattus norvegicus Butyrylcholinesterase IC50 7600.0 nM 10.1016/j.bmcl.2005.05.132
Rattus norvegicus Butyrylcholinesterase IC50 10833.33 nM 10.1021/acs.jmedchem.0c01863
Rattus norvegicus Butyrylcholinesterase IC50 12773.0 nM 10.1016/j.ejmech.2021.113827
Rattus norvegicus Butyrylcholinesterase IC50 20700.0 nM 10.1016/j.bmc.2018.11.015
Rattus norvegicus Butyrylcholinesterase IC50 20700.0 nM 10.1016/j.bmc.2019.01.040
Rattus norvegicus Butyrylcholinesterase IC50 20700.0 nM 10.1016/j.ejmech.2014.02.045
Rattus norvegicus Butyrylcholinesterase IC50 20700.0 nM 10.1016/j.ejmech.2019.111958
Rattus norvegicus Butyrylcholinesterase IC50 20700.0 nM 10.1016/j.ejmech.2021.113310
Rattus norvegicus Butyrylcholinesterase IC50 21400.0 nM 10.1016/j.bmc.2016.11.048
Rattus norvegicus Butyrylcholinesterase IC50 21400.0 nM 10.1016/j.bmc.2019.01.025
Rattus norvegicus Butyrylcholinesterase IC50 21400.0 nM 10.1016/j.bmc.2021.116074
Rattus norvegicus Butyrylcholinesterase IC50 37300.0 nM 10.1016/j.ejmech.2016.12.009
Rattus norvegicus Butyrylcholinesterase IC50 44600.0 nM 10.1016/j.bmc.2020.115400
Rattus norvegicus Choline acetylase IC50 5.3 nM 10.1021/jm00081a022
Rattus norvegicus Choline acetylase Inhibition 22.0 % 10.1021/jm0340602
Rattus norvegicus Cortical neurone Activity 65.5 % 10.1039/C9MD00211A
Rattus norvegicus Cortical neurone Activity 72.3 % 10.1039/C9MD00211A
Rattus norvegicus Cortical neurone Activity 85.9 % 10.1039/C9MD00211A
Rattus norvegicus Cortical neurone Activity nan None 10.1016/j.ejmech.2017.08.025
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Liver microsome K 0.00896 /min 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Liver microsome Stability 76.2 % 10.1016/j.ejmech.2015.02.055
Rattus norvegicus Liver microsome T1/2 1.222 hr 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Liver microsome T1/2 1.275 hr 10.1016/j.ejmech.2015.02.055
Rattus norvegicus Monoamine oxidase A IC50 850000.0 nM 10.1016/j.ejmech.2012.03.022
Rattus norvegicus Monoamine oxidase A IC50 850000.0 nM 10.1016/j.ejmech.2014.04.078
Rattus norvegicus Monoamine oxidase A IC50 850000.0 nM 10.1021/jm200853t
Rattus norvegicus Monoamine oxidase A IC50 854800000.0 nM None
Rattus norvegicus Monoamine oxidase B IC50 15000.0 nM 10.1016/j.ejmech.2012.03.022
Rattus norvegicus Monoamine oxidase B IC50 15000.0 nM 10.1016/j.ejmech.2014.04.078
Rattus norvegicus Monoamine oxidase B IC50 15000.0 nM 10.1021/jm200853t
Rattus norvegicus Monoamine oxidase B IC50 15400000.0 nM None
Rattus norvegicus Nicotinic acetylcholine receptor alpha6/alpha3/beta4 Inhibition 50.0 % 10.1016/j.bmc.2021.116355
Rattus norvegicus PC-12 Activity 10.3 % 10.1016/j.bmc.2023.117178
Rattus norvegicus PC-12 Activity 49.16 % 10.1016/j.ejmech.2019.05.055
Rattus norvegicus PC-12 Activity 57.12 % 10.1016/j.ejmech.2019.05.055
Rattus norvegicus PC-12 Activity 65.47 % 10.1016/j.ejmech.2019.05.055
Rattus norvegicus PC-12 Activity 68.91 % 10.1016/j.ejmech.2019.05.055
Rattus norvegicus PC-12 Activity 76.68 % 10.1016/j.ejmech.2019.05.055
Rattus norvegicus PC-12 Activity 90.0 % 10.1016/j.ejmech.2018.02.002
Rattus norvegicus PC-12 Activity nan None 10.1016/j.bmc.2008.07.014
Rattus norvegicus PC-12 Activity nan None 10.1016/j.bmcl.2021.128205
Rattus norvegicus PC-12 Activity nan None 10.1016/j.ejmech.2022.114503
Rattus norvegicus PC-12 Activity nan None 10.1016/j.ejmech.2022.114825
Rattus norvegicus Peripheral myelin protein 22 Potency 10181.5 nM None
Rattus norvegicus Plasma Cp 0.06 uM 10.1016/j.bmcl.2014.11.046
Rattus norvegicus Plasma Cp 2.0 ug/L 10.1021/acs.jmedchem.7b01086
Rattus norvegicus Rattus norvegicus Activity 3.9 None 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 21.9 cm/s 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 25.0 cm 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 26.82 mol/min 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus Activity 28.24 mol/min 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus Activity 28.24 nmol/min 10.1016/j.bmc.2017.01.010
Rattus norvegicus Rattus norvegicus Activity 28.54 mol/min 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus Activity 30.86 mol/min 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus Activity 31.25 mol/min 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus Activity 32.38 mol/min 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus Activity 45.6 % 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 46.8 % 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 51.3 % 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 55.6 % 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 92.6 cm 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity 1203.0 % 10.1021/acs.jmedchem.6b01662
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2017.01.010
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2018.08.035
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2020.115721
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2021.116109
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2016.08.062
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2018.01.039
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2017.12.053
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2019.02.030
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2019.06.001
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2019.111613
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2019.111707
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2020.112743
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.1c01303
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.6b00426
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acsmedchemlett.8b00214
Rattus norvegicus Rattus norvegicus Inhibition 58.0 % 10.1016/j.bmc.2014.08.016
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1016/j.ejmech.2019.111613
Rattus norvegicus Rattus norvegicus TIME 0.001389 hr 10.1021/acs.jmedchem.5b01222
Rattus norvegicus Rattus norvegicus TIME 0.002036 hr 10.1016/j.bmc.2017.01.010
Rattus norvegicus Rattus norvegicus TIME 0.002161 hr 10.1016/j.bmc.2017.01.010
Rattus norvegicus Rattus norvegicus TIME 0.003994 hr 10.1016/j.bmc.2017.01.010
Rattus norvegicus Rattus norvegicus TIME 0.004689 hr 10.1016/j.bmc.2017.01.010
Rattus norvegicus Rattus norvegicus TIME 0.00625 hr 10.1016/j.ejmech.2019.02.030
Rattus norvegicus Rattus norvegicus TIME 0.01046 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01086 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01199 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01254 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01496 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01514 hr 10.1016/j.bmcl.2013.03.026
Rattus norvegicus Rattus norvegicus TIME 0.01539 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01574 hr 10.1016/j.bmcl.2013.03.026
Rattus norvegicus Rattus norvegicus TIME 0.01701 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01736 hr 10.1016/j.bmcl.2013.03.026
Rattus norvegicus Rattus norvegicus TIME 0.01783 hr 10.1016/j.bmc.2013.06.003
Rattus norvegicus Rattus norvegicus TIME 0.01815 hr 10.1016/j.bmcl.2013.03.026
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 18.24 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.173 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.2 % 10.6019/CHEMBL4495565
Torpedo californica Acetylcholinesterase IC50 12.0 nM 10.1016/s0960-894x(98)00076-6
Torpedo californica Acetylcholinesterase IC50 23.0 nM 10.1016/j.ejmech.2015.08.061
Torpedo californica Acetylcholinesterase IC50 23.0 nM 10.1016/j.ejmech.2018.05.031
Torpedo californica Acetylcholinesterase IC50 48.0 nM 10.1021/jm981101z
None ADMET Activity nan None 10.1016/j.bmc.2021.116109
None ADMET Activity nan None 10.1016/j.ejmech.2022.114841
None ADMET Activity nan None 10.1021/acs.jmedchem.1c00167
None ADMET CL 0.001 uL/min 10.1124/dmd.111.039180
None ADMET CL 9.6 mL.min-1.g-1 10.1016/j.ejmech.2021.114045
None ADMET CL 14.4 mL.min-1.g-1 10.1016/j.ejmech.2019.111857
None ADMET CL 17.6 mL.min-1.g-1 10.1016/j.ejmech.2019.06.001
None ADMET CL 34.8 mL.min-1.g-1 10.1016/j.ejmech.2021.114045
None ADMET CL nan None 10.1124/dmd.111.039180
None ADMET Cp 6.46 ug ml-1 10.1021/acs.jmedchem.0c01775
None ADMET Ct 6.13 ug/g 10.1021/acs.jmedchem.0c01775
None ADMET Fu 0.082 None 10.1124/dmd.111.038778
None ADMET HIA 97.95 % 10.1016/j.ejmech.2014.04.078
None ADMET K 0.00889 /min 10.1021/acs.jmedchem.7b01417
None ADMET K 0.00917 min 10.1016/j.ejmech.2018.12.013
None ADMET LD50 3.7 mg.kg-1 10.1016/j.bmc.2018.12.007
None ADMET LD50 28.12 mg.kg-1 10.1016/j.ejmech.2022.114841
None ADMET LD50 32.5 mg.kg-1 10.1016/j.ejmech.2022.114152
None ADMET Peff 6.69 10'-4 cm/s 10.1016/j.ejmech.2014.04.078
None ADMET Peff 6.89 10^-6 cm/s 10.1016/j.bmc.2019.02.031
None ADMET Peff 7.3 10'-6 cm/s 10.1016/j.bmcl.2016.05.087
None ADMET Peff 21.93 10^-6 cm/s 10.1021/acs.jmedchem.1c00048
None ADMET Peff 21.93 10^-6 cm/s 10.1021/acsmedchemlett.0c00375
None ADMET permeability 2.1 10^-6 cm/s 10.1016/j.ejmech.2021.114045
None ADMET permeability 7.2 10^-6 cm/s 10.1016/j.bmc.2020.115721
None ADMET permeability 7.3 10'-6 cm/s 10.1016/j.ejmech.2016.09.078
None ADMET permeability 7.6 10^-6 cm/s 10.1016/j.ejmech.2019.111707
None ADMET permeability 9.8 10^-6 cm/s 10.1016/j.ejmech.2020.112593
None ADMET permeability 15.57 10^-6 cm/s 10.1016/j.bmc.2021.116385
None ADMET permeability 21.0 10^-6 cm/s 10.1016/j.ejmech.2022.114193
None ADMET permeability 21.9 10^-6 cm/s 10.1016/j.ejmech.2020.113112
None ADMET permeability 22.8 10^-6 cm/s 10.1016/j.ejmech.2021.113224
None ADMET permeability 23.1 10^-6 cm/s 10.1016/j.ejmech.2021.113911
None ADMET permeability 23.4 10^-6 cm/s 10.1016/j.bmcl.2020.127370
None ADMET permeability 30.29 10^-6 cm/s 10.1016/j.ejmech.2022.114825
None ADMET PPB 38.69 % 10.6019/CHEMBL3301361
None ADMET PPB 66.1 % 10.6019/CHEMBL3301361
None ADMET PPB 84.62 % 10.1016/j.ejmech.2014.04.078
None ADMET PPB 89.49 % 10.6019/CHEMBL3301361
None ADMET Ratio IC50 6136.0 None 10.1016/j.ejmech.2021.113827
None ADMET T1/2 0.7667 hr 10.1016/j.ejmech.2021.114045
None ADMET T1/2 1.21 hr 10.1016/j.ejmech.2018.08.005
None ADMET T1/2 1.26 hr 10.1016/j.ejmech.2018.12.013
None ADMET T1/2 1.298 hr 10.1021/acs.jmedchem.7b01417
None ADMET T1/2 1.317 hr 10.1016/j.ejmech.2019.06.001
None ADMET T1/2 1.6 hr 10.1016/j.ejmech.2019.111857
None ADMET T1/2 2.417 hr 10.1016/j.ejmech.2021.114045
None ADMET TIME 0.0466 hr 10.1016/j.ejmech.2018.11.049
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 6.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET Activity 19.12 ug 10.1016/j.bmc.2017.01.010
None NON-PROTEIN TARGET Activity 43.6 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 48.7 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 58.3 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 63.2 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 64.2 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 65.3 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 67.0 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 69.5 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 70.0 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity nan None 10.1021/acs.jmedchem.6b00636
None NON-PROTEIN TARGET Activity nan None 10.1021/jm401047q
None NON-PROTEIN TARGET Fu 0.04 None 10.1016/j.bmcl.2014.11.046
None NON-PROTEIN TARGET Fu 0.113 None 10.1124/dmd.111.038778
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Peff 12.0 ucm/s 10.1016/j.ejmech.2015.02.055
None NON-PROTEIN TARGET Peff 28.3 ucm/s 10.1016/j.ejmech.2015.02.055
None NON-PROTEIN TARGET Ratio 0.04 None 10.1021/jm401047q
None No relevant target Activity 0.05 equiv 10.1016/j.ejmech.2017.02.042
None No relevant target Activity 0.1 equiv 10.1016/j.ejmech.2017.02.042
None No relevant target Activity 0.63 equiv 10.1016/j.ejmech.2017.02.045
None No relevant target Activity 4.4 % 10.1016/j.ejmech.2018.09.010
None No relevant target Activity 10.0 % 10.1016/j.ejmech.2018.11.049
None No relevant target Activity 10.77 % 10.1016/j.bmc.2023.117178
None No relevant target Activity 11.3 % 10.1016/j.bmc.2023.117178
None No relevant target Activity 46.1 microM/min 10.1016/j.bmc.2013.12.066
None No relevant target Activity 59.9 % 10.1021/acs.jmedchem.6b00426
None No relevant target Activity 60.1 % 10.1016/j.ejmech.2018.02.078
None No relevant target Activity 74.6 % 10.1016/j.ejmech.2018.02.078
None No relevant target Activity 75.5 % 10.1021/acs.jmedchem.6b00426
None No relevant target Activity 96.0 % 10.1016/j.ejmech.2017.08.021
None No relevant target Activity nan None 10.1016/j.bmc.2014.12.057
None No relevant target Activity nan None 10.1016/j.bmc.2015.08.024
None No relevant target Activity nan None 10.1016/j.bmc.2016.04.041
None No relevant target Activity nan None 10.1016/j.bmc.2016.06.027
None No relevant target Activity nan None 10.1016/j.bmc.2016.07.025
None No relevant target Activity nan None 10.1016/j.bmc.2017.01.010
None No relevant target Activity nan None 10.1016/j.bmc.2018.11.015
None No relevant target Activity nan None 10.1016/j.bmc.2020.115400
None No relevant target Activity nan None 10.1016/j.ejmech.2014.02.045
None No relevant target Activity nan None 10.1016/j.ejmech.2016.04.053
None No relevant target Activity nan None 10.1016/j.ejmech.2016.05.055
None No relevant target Activity nan None 10.1016/j.ejmech.2016.09.057
None No relevant target Activity nan None 10.1016/j.ejmech.2017.02.039
None No relevant target Activity nan None 10.1016/j.ejmech.2017.04.054
None No relevant target Activity nan None 10.1016/j.ejmech.2017.04.064
None No relevant target Activity nan None 10.1016/j.ejmech.2017.07.077
None No relevant target Activity nan None 10.1016/j.ejmech.2017.08.021
None No relevant target Activity nan None 10.1016/j.ejmech.2019.06.026
None No relevant target Activity nan None 10.1016/j.ejmech.2019.07.021
None No relevant target Activity nan None 10.1016/j.ejmech.2019.111737
None No relevant target Activity nan None 10.1016/j.ejmech.2020.113124
None No relevant target Activity nan None 10.1021/acs.jmedchem.7b00702
None No relevant target FC nan None 10.1016/j.ejmech.2020.112180
None No relevant target IC50 nan None 10.1016/j.bmcl.2015.10.051
None No relevant target IC50 nan None 10.1039/C6MD00053C
None No relevant target Inhibition 1.3 % 10.1016/j.ejmech.2021.113735
None No relevant target Inhibition 5.0 % 10.1016/j.ejmech.2017.04.054
None No relevant target Inhibition 11.3 % 10.1016/j.ejmech.2016.07.052
None No relevant target Inhibition 20.0 % 10.1016/j.bmc.2019.02.031
None No relevant target Inhibition 81.89 % 10.1016/j.ejmech.2019.05.055
None No relevant target Inhibition nan % 10.1016/j.ejmech.2017.08.021
None No relevant target LogD7.4 2.41 None 10.6019/CHEMBL3301361
None No relevant target Peff 6.8 ucm/s 10.1016/j.ejmech.2018.02.083
None No relevant target Peff 6.861 10'-6 cm/s 10.1016/j.ejmech.2019.02.030
None No relevant target Peff 7.3 10'-6 cm/s 10.1021/acsmedchemlett.9b00071
None No relevant target Peff 7.54 10'-6 cm/s 10.1016/j.ejmech.2018.11.049
None No relevant target Peff 8.9 ucm/s 10.1016/j.ejmech.2018.02.083
None No relevant target Peff 21.93 10'-6 cm/s 10.1016/j.ejmech.2019.02.012
None No relevant target Peff 22.91 ucm/s 10.1016/j.bmcl.2018.07.019
None No relevant target Peff nan None 10.1016/j.bmc.2019.07.001
None No relevant target permeability 7.3 10'-6 cm/s 10.1016/j.ejmech.2017.07.058
None No relevant target permeability 8.32 10'-6 cm/s 10.1016/j.ejmech.2019.111613
None No relevant target permeability nan None 10.1016/j.ejmech.2017.02.034
None No relevant target permeability nan None 10.1016/j.ejmech.2018.07.026
None No relevant target pKa 9.0 None 10.1007/s11095-013-1232-z
None No relevant target pKa 9.08 None 10.1007/s11095-013-1232-z
None No relevant target pKa 9.08 None 10.1021/jm070524a
None No relevant target Ratio nan None 10.1016/j.bmcl.2016.02.079
None No relevant target Ratio nan None 10.1016/j.ejmech.2014.09.081
None No relevant target Ratio nan None 10.1016/j.ejmech.2016.07.052
None No relevant target Ratio nan None 10.1039/C6MD00053C
None No relevant target Retention_time 3.2 min 10.1016/j.ejmech.2015.02.055
None No relevant target Solubility 429000.0 nM 10.1016/j.bmcl.2010.10.068
None Phospholipidosis Phospholipidosis nan None 10.1021/ci6004542
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Unchecked Activity 5.89 ng/ml 10.1016/j.ejmech.2022.114152
None Unchecked Activity 7.84 % 10.1021/acs.jmedchem.6b00426
None Unchecked Activity 46.1 microM/min 10.1021/jm401047q
None Unchecked Activity 47.3 % 10.1039/C9MD00211A
None Unchecked Activity 72.0 % 10.1039/C9MD00211A
None Unchecked Activity 81.3 % 10.1039/C9MD00211A
None Unchecked Activity 90.2 % 10.1016/j.ejmech.2020.113124
None Unchecked Activity 95.4 % 10.1016/j.ejmech.2020.113124
None Unchecked Activity 178.0 % 10.1016/j.bmc.2022.116950
None Unchecked Activity nan None 10.1016/j.bmcl.2021.128205
None Unchecked Activity nan None 10.1016/j.ejmech.2019.111737
None Unchecked Activity nan None 10.1016/j.ejmech.2019.111958
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112180
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112257
None Unchecked Activity nan None 10.1021/acs.jmedchem.6b00426
None Unchecked Activity nan None 10.1021/jm801292b
None Unchecked Hepatotoxicity (acute) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 3400.0 nM 10.1016/j.bmcl.2022.128602
None Unchecked IC50 4420.0 nM 10.1016/j.bmc.2017.03.070
None Unchecked IC50 4420.0 nM 10.1016/j.ejmech.2017.02.039
None Unchecked IC50 17500.0 nM 10.1016/j.ejmech.2021.113964
None Unchecked IC50 20700.0 nM 10.1016/j.bmc.2015.01.042
None Unchecked IC50 20700.0 nM 10.1016/j.bmcl.2016.02.079
None Unchecked IC50 20700.0 nM 10.1016/j.ejmech.2015.02.063
None Unchecked IC50 20700.0 nM 10.1016/j.ejmech.2017.04.054
None Unchecked IC50 20730.0 nM 10.1016/j.ejmech.2021.114098
None Unchecked IC50 21400.0 nM 10.1016/j.bmc.2017.02.027
None Unchecked IC50 21400.0 nM 10.1016/j.bmc.2018.02.037
None Unchecked IC50 43000.0 nM 10.1016/j.bmc.2012.11.044
None Unchecked IC50 62700.0 nM 10.1021/jm901902w
None Unchecked IC50 86500.0 nM 10.1016/j.bmc.2007.07.003
None Unchecked IC50 nan None 10.1016/j.bmcl.2021.128306
None Unchecked IC50 nan None 10.1016/j.ejmech.2020.112180
None Unchecked IC50 nan None 10.1016/j.ejmech.2021.113973
None Unchecked Inhibition 5.0 % 10.1016/j.bmc.2010.01.071
None Unchecked Inhibition 5.0 % 10.1016/j.bmc.2018.01.030
None Unchecked Inhibition 5.0 % 10.1016/j.bmc.2019.01.040
None Unchecked Inhibition 9.0 % 10.1016/j.bmc.2020.115820
None Unchecked Inhibition 20.0 % 10.1016/j.ejmech.2020.112282
None Unchecked Inhibition 35.0 % 10.1016/j.bmc.2020.115820
None Unchecked Inhibition 46.5 % 10.1016/j.ejmech.2022.114152
None Unchecked Inhibition 46.7 % 10.1016/j.ejmech.2021.113278
None Unchecked Inhibition nan % 10.1016/j.bmc.2020.115721
None Unchecked Inhibition nan % 10.1016/j.bmcl.2012.05.077
None Unchecked Inhibition nan % 10.1016/j.ejmech.2019.07.021
None Unchecked Inhibition nan % 10.1016/j.ejmech.2019.111707
None Unchecked Inhibition nan % 10.1016/j.ejmech.2019.111737
None Unchecked Inhibition nan % 10.1016/j.ejmech.2019.111958
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.112180
None Unchecked Inhibition nan % 10.1016/j.ejmech.2022.114305
None Unchecked Inhibition nan % 10.1016/j.ejmech.2022.114503
None Unchecked Inhibition nan % 10.1021/jm101299d
None Unchecked Potency 40533.4 nM None
None Unchecked Ratio 0.005 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.006 None 10.1093/toxsci/kft176
None Unchecked Ratio 1.2 None 10.1021/jm401047q
None Unchecked Ratio 510.0 None 10.1021/jm981101z
None Unchecked Ratio CC50/IC50 298.33 None 10.1016/j.ejmech.2019.02.053
None Unchecked Ratio IC50 0.001 None 10.1016/j.ejmech.2020.112140
None Unchecked Ratio IC50 0.003 None 10.1016/j.ejmech.2019.05.055
None Unchecked Ratio IC50 0.01 None 10.1021/acs.jmedchem.6b00426
None Unchecked Ratio IC50 0.01 None 10.1039/C5MD00274E
None Unchecked Ratio IC50 0.0152 None 10.1016/j.ejmech.2015.10.001
None Unchecked Ratio IC50 0.017 None 10.1016/j.ejmech.2013.12.028
None Unchecked Ratio IC50 0.02 None 10.1016/j.bmc.2018.06.018
None Unchecked Ratio IC50 0.02 None 10.1016/j.ejmech.2012.03.022
None Unchecked Ratio IC50 0.02 None 10.1016/j.ejmech.2014.04.078
None Unchecked Ratio IC50 0.02 None 10.1016/j.ejmech.2021.113224
None Unchecked Ratio IC50 0.02 None 10.1016/j.ejmech.2021.113964
None Unchecked Ratio IC50 0.02 None 10.1021/jm200853t
None Unchecked Ratio IC50 0.065 None 10.1016/j.bmc.2018.08.035
None Unchecked Ratio IC50 0.065 None 10.1016/j.ejmech.2018.05.031
None Unchecked Ratio IC50 0.12 None 10.1016/j.bmc.2022.117146
None Unchecked Ratio IC50 0.17 None 10.1016/j.ejmech.2015.10.001
None Unchecked Ratio IC50 0.251 None 10.1039/C6MD00053C
None Unchecked Ratio IC50 22.08 None 10.1016/j.bmcl.2021.128306
None Unchecked Ratio IC50 39.81 None 10.1016/j.bmc.2014.12.057
None Unchecked Ratio IC50 42.1 None 10.1016/j.ejmech.2019.02.030
None Unchecked Ratio IC50 42.8 None 10.1016/j.ejmech.2019.111613
None Unchecked Ratio IC50 47.78 None 10.1016/j.ejmech.2022.114152
None Unchecked Ratio IC50 51.6 None 10.1016/j.ejmech.2016.07.052
None Unchecked Ratio IC50 55.0 None 10.1016/j.bmc.2014.02.046
None Unchecked Ratio IC50 57.87 None 10.1016/j.ejmech.2017.04.064
None Unchecked Ratio IC50 60.0 None 10.1016/j.bmcl.2015.09.063
None Unchecked Ratio IC50 61.3 None 10.1039/C2MD20076G
None Unchecked Ratio IC50 65.0 None 10.1016/j.ejmech.2013.12.028
None Unchecked Ratio IC50 66.0 None 10.1016/j.ejmech.2016.07.052
None Unchecked Ratio IC50 66.04 None 10.1016/j.ejmech.2018.08.005
None Unchecked Ratio IC50 66.55 None 10.1016/j.ejmech.2016.04.053
None Unchecked Ratio IC50 77.0 None 10.1039/c9md00441f
None Unchecked Ratio IC50 82.6 None 10.1016/j.bmc.2016.04.041
None Unchecked Ratio IC50 84.0 None 10.1016/j.bmc.2016.07.025
None Unchecked Ratio IC50 85.4 None 10.1016/j.bmc.2017.02.048
None Unchecked Ratio IC50 86.1 None 10.1016/j.bmc.2016.06.027
None Unchecked Ratio IC50 86.1 None 10.1016/j.ejmech.2016.09.057
None Unchecked Ratio IC50 88.1 None 10.1016/j.ejmech.2014.09.081
None Unchecked Ratio IC50 88.6 None 10.1021/jm401047q
None Unchecked Ratio IC50 94.8 None 10.1016/j.bmc.2016.02.023
None Unchecked Ratio IC50 98.61 None 10.1016/j.ejmech.2021.114095
None Unchecked Ratio IC50 110.2 None 10.1016/j.ejmech.2021.113964
None Unchecked Ratio IC50 111.61 None 10.1016/j.ejmech.2014.06.034
None Unchecked Ratio IC50 111.9 None 10.1016/j.ejmech.2017.02.045
None Unchecked Ratio IC50 111.9 None 10.1016/j.ejmech.2017.07.055
None Unchecked Ratio IC50 114.0 None 10.1016/j.bmc.2016.04.015
None Unchecked Ratio IC50 119.0 None 10.1016/j.bmc.2017.03.070
None Unchecked Ratio IC50 120.0 None 10.1021/acsmedchemlett.5b00483
None Unchecked Ratio IC50 120.0 None 10.1039/C7MD00199A
None Unchecked Ratio IC50 121.0 None 10.1016/j.bmc.2008.07.014
None Unchecked Ratio IC50 126.0 None 10.1016/j.bmc.2007.07.003
None Unchecked Ratio IC50 136.38 None 10.1016/j.ejmech.2022.114210
None Unchecked Ratio IC50 138.5 None 10.1016/j.ejmech.2017.07.055
None Unchecked Ratio IC50 166.7 None 10.1016/j.bmc.2019.06.004
None Unchecked Ratio IC50 166.7 None 10.1016/j.ejmech.2019.04.038
None Unchecked Ratio IC50 177.7 None 10.1016/j.bmc.2015.08.024
None Unchecked Ratio IC50 179.5 None 10.1016/j.bmcl.2012.04.029
None Unchecked Ratio IC50 180.0 None 10.1016/j.bmc.2022.116952
None Unchecked Ratio IC50 180.0 None 10.1016/j.ejmech.2018.01.066
None Unchecked Ratio IC50 183.0 None 10.1016/j.bmc.2015.01.045
None Unchecked Ratio IC50 188.0 None 10.1021/acs.jmedchem.6b00356
None Unchecked Ratio IC50 202.36 None 10.1016/j.ejmech.2015.10.046
None Unchecked Ratio IC50 204.0 None 10.1016/j.ejmech.2021.113827
None Unchecked Ratio IC50 226.0 None 10.1039/C7MD00199A
None Unchecked Ratio IC50 236.0 None 10.1016/j.ejmech.2015.02.055
None Unchecked Ratio IC50 250.0 None 10.1016/j.ejmech.2013.06.021
None Unchecked Ratio IC50 250.0 None 10.1016/j.ejmech.2018.07.026
None Unchecked Ratio IC50 250.0 None 10.1016/j.ejmech.2018.07.056
None Unchecked Ratio IC50 250.5 None 10.1016/j.ejmech.2020.112180
None Unchecked Ratio IC50 251.0 None 10.1016/j.bmc.2017.03.070
None Unchecked Ratio IC50 251.0 None 10.1016/j.bmcl.2017.09.055
None Unchecked Ratio IC50 251.0 None 10.1016/j.bmcl.2017.09.057
None Unchecked Ratio IC50 251.0 None 10.1016/j.bmcl.2019.126625
None Unchecked Ratio IC50 251.0 None 10.1016/j.ejmech.2017.02.039
None Unchecked Ratio IC50 251.0 None 10.1016/j.ejmech.2019.07.021
None Unchecked Ratio IC50 251.0 None 10.1016/j.ejmech.2019.111737
None Unchecked Ratio IC50 268.0 None 10.1039/C6MD00053C
None Unchecked Ratio IC50 274.0 None 10.1016/j.bmc.2016.02.023
None Unchecked Ratio IC50 289.0 None 10.1016/j.ejmech.2017.07.077
None Unchecked Ratio IC50 306.0 None 10.1021/acs.jmedchem.7b00702
None Unchecked Ratio IC50 320.0 None 10.1016/j.ejmech.2021.114045
None Unchecked Ratio IC50 371.0 None 10.1016/j.bmc.2010.01.071
None Unchecked Ratio IC50 381.0 None 10.1016/j.bmc.2013.06.003
None Unchecked Ratio IC50 381.0 None 10.1016/j.bmc.2017.01.010
None Unchecked Ratio IC50 381.0 None 10.1016/j.bmcl.2013.03.026
None Unchecked Ratio IC50 381.0 None 10.1016/j.ejmech.2018.11.049
None Unchecked Ratio IC50 384.0 None 10.1016/j.ejmech.2013.10.024
None Unchecked Ratio IC50 384.3 None 10.1016/j.ejmech.2013.07.038
None Unchecked Ratio IC50 384.3 None 10.1016/j.ejmech.2014.01.017
None Unchecked Ratio IC50 400.0 None 10.1016/j.ejmech.2015.08.052
None Unchecked Ratio IC50 428.0 None 10.1016/j.ejmech.2016.09.041
None Unchecked Ratio IC50 465.0 None 10.1016/j.ejmech.2019.111737
None Unchecked Ratio IC50 888.0 None 10.1016/j.bmc.2014.08.016
None Unchecked Ratio IC50 1100.0 None 10.1016/j.ejmech.2012.03.022
None Unchecked Ratio IC50 1100.0 None 10.1016/j.ejmech.2014.04.078
None Unchecked Ratio IC50 1100.0 None 10.1021/jm200853t
None Unchecked Ratio IC50 1250.0 None 10.1016/j.ejmech.2018.01.066
None Unchecked Ratio IC50 1344.0 None 10.1016/j.bmc.2012.11.044
None Unchecked Ratio IC50 1380.0 None 10.1016/j.bmc.2015.01.042
None Unchecked Ratio IC50 1380.0 None 10.1016/j.bmcl.2016.02.079
None Unchecked Ratio IC50 1380.0 None 10.1016/j.ejmech.2015.02.063
None Unchecked Ratio IC50 1380.0 None 10.1016/j.ejmech.2017.04.054
None Unchecked Ratio IC50 5417.0 None 10.1021/acs.jmedchem.0c01863
None Unchecked Ratio IC50 nan None 10.1016/j.bmcl.2020.127659
None Unchecked Ratio IC50 nan None 10.1039/C7MD00199A
None Unchecked Ratio Ki 214.0 None 10.1021/acsmedchemlett.5b00483
None Unchecked Selectivity Index 11.7 None 10.1016/j.ejmech.2021.113541
None Unchecked Selectivity Index 180.0 None 10.1016/j.ejmech.2020.112415
None Unchecked Selectivity Index 183.0 None 10.1016/j.ejmech.2015.01.027
None Unchecked Selectivity ratio 10000.0 None 10.1016/j.bmc.2017.02.017

Metabolism Information