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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK323317

Synonym: None

IUPAC Name: benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

Structure

SMILES: CC(C)C[C@@H](C=O)N=C(O)[C@H](CC(C)C)N=C(O)[C@H](CC(C)C)N=C(O)OCC1=CC=CC=C1

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InChI: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

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InChIKey: TZYWCYJVHRLUCT-VABKMULXSA-N

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Reference

PubChem CID: 462382

CAS: 133407-82-6

NPASS: NPC481840

Properties Information

Molecule Weight: 475.6300000000002

TPSA？: 124.07

MolLogP？: 5.473200000000005

Number of H-Donors: 3

Number of H-Acceptors: 5

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Chlorocebus sabaeus Vero C1008 CC50 2900.0 nM 10.6019/CHEMBL4495565
Chlorocebus sabaeus Vero C1008 CC50 3040.0 nM 10.6019/CHEMBL4495565
Homo sapiens 20S proteasome IC50 68.0 nM 10.1016/j.bmcl.2005.02.013
Homo sapiens 20S proteasome IC50 1400.0 nM 10.1016/j.bmcl.2005.02.013
Homo sapiens 20S proteasome IC50 4500.0 nM 10.1016/j.bmcl.2005.02.013
Homo sapiens 697 IC50 2262.26 nM 10.6019/CHEMBL1201861
Homo sapiens 697 IC50 14451.08 nM 10.6019/CHEMBL1201861
Homo sapiens 8-MG-BA IC50 398.37 nM 10.6019/CHEMBL1201861
Homo sapiens 8-MG-BA IC50 22956.02 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 32.79 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 300.94 nM 10.6019/CHEMBL1201861
Homo sapiens A253 cell line IC50 161.28 nM 10.6019/CHEMBL1201861
Homo sapiens A253 cell line IC50 3763.02 nM 10.6019/CHEMBL1201861
Homo sapiens A2780 Activity nan None 10.1074/jbc.m703796200
Homo sapiens A388 IC50 90.65 nM 10.6019/CHEMBL1201861
Homo sapiens A388 IC50 4395.07 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 2381.86 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 49806.13 nM 10.6019/CHEMBL1201861
Homo sapiens A498 IC50 12706.94 nM 10.6019/CHEMBL1201861
Homo sapiens A498 IC50 23270.81 nM 10.6019/CHEMBL1201861
Homo sapiens A4-Fuk IC50 6081.18 nM 10.6019/CHEMBL1201861
Homo sapiens A4-Fuk IC50 47710.57 nM 10.6019/CHEMBL1201861
Homo sapiens A704 IC50 486.92 nM 10.6019/CHEMBL1201861
Homo sapiens ACN IC50 226.38 nM 10.6019/CHEMBL1201861
Homo sapiens ACN IC50 2843.94 nM 10.6019/CHEMBL1201861
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 14125.4 nM None
Homo sapiens ALL-PO IC50 5637.95 nM 10.6019/CHEMBL1201861
Homo sapiens ALL-PO IC50 40826.4 nM 10.6019/CHEMBL1201861
Homo sapiens AM-38 IC50 12563.31 nM 10.6019/CHEMBL1201861
Homo sapiens AM-38 IC50 43439.8 nM 10.6019/CHEMBL1201861
Homo sapiens ARH-77 IC50 5670.87 nM 10.6019/CHEMBL1201861
Homo sapiens ARH-77 IC50 18374.08 nM 10.6019/CHEMBL1201861
Homo sapiens ATN-1 IC50 5763.59 nM 10.6019/CHEMBL1201861
Homo sapiens ATN-1 IC50 74504.98 nM 10.6019/CHEMBL1201861
Homo sapiens BB30-HNC IC50 1726.85 nM 10.6019/CHEMBL1201861
Homo sapiens BB30-HNC IC50 31082.31 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 490.96 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 1499.11 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 568.11 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 18575.17 nM 10.6019/CHEMBL1201861
Homo sapiens BC-3 IC50 15398.01 nM 10.6019/CHEMBL1201861
Homo sapiens BC-3 IC50 16565.99 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 562.07 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 134044.39 nM 10.6019/CHEMBL1201861
Homo sapiens Becker IC50 796.21 nM 10.6019/CHEMBL1201861
Homo sapiens Becker IC50 3202.54 nM 10.6019/CHEMBL1201861
Homo sapiens BL-41 IC50 69.47 nM 10.6019/CHEMBL1201861
Homo sapiens BL-41 IC50 2118.04 nM 10.6019/CHEMBL1201861
Homo sapiens BL-70 IC50 693.88 nM 10.6019/CHEMBL1201861
Homo sapiens BL-70 IC50 58800.18 nM 10.6019/CHEMBL1201861
Homo sapiens BOKU IC50 15960.84 nM 10.6019/CHEMBL1201861
Homo sapiens BT-474 IC50 5231.02 nM 10.6019/CHEMBL1201861
Homo sapiens BT-474 IC50 97760.93 nM 10.6019/CHEMBL1201861
Homo sapiens BV-173 IC50 27895.46 nM 10.6019/CHEMBL1201861
Homo sapiens BV-173 IC50 108727.96 nM 10.6019/CHEMBL1201861
Homo sapiens C2BBe1 IC50 279.07 nM 10.6019/CHEMBL1201861
Homo sapiens C2BBe1 IC50 1200.33 nM 10.6019/CHEMBL1201861
Homo sapiens C8166 IC50 27935.27 nM 10.6019/CHEMBL1201861
Homo sapiens C8166 IC50 345337.78 nM 10.6019/CHEMBL1201861
Homo sapiens CA46 IC50 10360.95 nM 10.6019/CHEMBL1201861
Homo sapiens CA46 IC50 12929.83 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-148 IC50 17979.59 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-148 IC50 49101.03 nM 10.6019/CHEMBL1201861
Homo sapiens Calpain 2 Ki 653.0 nM 10.1021/acsmedchemlett.5b00401
Homo sapiens Calpain-9 IC50 9880.0 nM None
Homo sapiens Calu-6 IC50 5622.0 nM 10.6019/CHEMBL1201861
Homo sapiens Calu-6 IC50 7275.63 nM 10.6019/CHEMBL1201861
Homo sapiens CAS-1 IC50 154.82 nM 10.6019/CHEMBL1201861
Homo sapiens CAS-1 IC50 2861.26 nM 10.6019/CHEMBL1201861
Homo sapiens Cathepsin B Ki 12.0 nM 10.1021/jm058289o
Homo sapiens Cathepsin B Ki 230.0 nM 10.1021/acsmedchemlett.5b00401
Homo sapiens Cathepsin K Ki 1.4 nM 10.1021/jm990412m
Homo sapiens Cathepsin L IC50 0.15 nM 10.1021/acs.jmedchem.2c01005
Homo sapiens Cathepsin S Ki app nan None 10.1021/jm058289o
Homo sapiens CCRF-CEM IC50 476.74 nM 10.6019/CHEMBL1201861
Homo sapiens CCRF-CEM IC50 2312.55 nM 10.6019/CHEMBL1201861
Homo sapiens CESS IC50 170.6 nM 10.6019/CHEMBL1201861
Homo sapiens CESS IC50 12062.89 nM 10.6019/CHEMBL1201861
Homo sapiens CGTH-W-1 IC50 15086.68 nM 10.6019/CHEMBL1201861
Homo sapiens CGTH-W-1 IC50 36904.78 nM 10.6019/CHEMBL1201861
Homo sapiens CHP-126 IC50 21618.08 nM 10.6019/CHEMBL1201861
Homo sapiens CHP-126 IC50 237145.77 nM 10.6019/CHEMBL1201861
Homo sapiens CMK IC50 311.2 nM 10.6019/CHEMBL1201861
Homo sapiens CMK IC50 8845.38 nM 10.6019/CHEMBL1201861
Homo sapiens Cofilin-1 Activity nan None 10.1038/nchembio790
Homo sapiens COLO-320-HSR IC50 3756.34 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-320-HSR IC50 209003.71 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 81588.39 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 136606.56 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 906.58 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 43468.65 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 28295.62 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 525412.67 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 5404.15 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 14799.35 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 242.57 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 35109.12 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L279 IC50 26792.23 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L279 IC50 186961.37 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 12938.17 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 231161.59 nM 10.6019/CHEMBL1201861
Homo sapiens CP66-MEL IC50 75.0 nM 10.6019/CHEMBL1201861
Homo sapiens CP66-MEL IC50 836.46 nM 10.6019/CHEMBL1201861
Homo sapiens CP67-MEL IC50 267.3 nM 10.6019/CHEMBL1201861
Homo sapiens CPC-N IC50 24020.1 nM 10.6019/CHEMBL1201861
Homo sapiens CPC-N IC50 188944.82 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 779.55 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 123947.98 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 10097.91 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 115233.79 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 44834.19 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 483609.13 nM 10.6019/CHEMBL1201861
Homo sapiens D-247MG IC50 72.09 nM 10.6019/CHEMBL1201861
Homo sapiens D-247MG IC50 23948.87 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 160.06 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 13565.03 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 8917.19 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 21458.46 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 4011.66 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 61293.27 nM 10.6019/CHEMBL1201861
Homo sapiens D-392MG IC50 191.15 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 1672.11 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 148717.27 nM 10.6019/CHEMBL1201861
Homo sapiens D-542MG IC50 59.57 nM 10.6019/CHEMBL1201861
Homo sapiens Daudi IC50 2054.59 nM 10.6019/CHEMBL1201861
Homo sapiens Daudi IC50 18923.13 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 13988.52 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 40444.07 nM 10.6019/CHEMBL1201861
Homo sapiens DEL IC50 1592.1 nM 10.6019/CHEMBL1201861
Homo sapiens DEL IC50 41440.51 nM 10.6019/CHEMBL1201861
Homo sapiens DG-75 IC50 65872.96 nM 10.6019/CHEMBL1201861
Homo sapiens DG-75 IC50 113351.66 nM 10.6019/CHEMBL1201861
Homo sapiens DJM-1 IC50 2025.52 nM 10.6019/CHEMBL1201861
Homo sapiens DJM-1 IC50 119978.31 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-114 IC50 1445.39 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-114 IC50 253810.52 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-153 IC50 117410.93 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-153 IC50 121744.92 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 20955.75 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 117382.4 nM 10.6019/CHEMBL1201861
Homo sapiens DOHH-2 IC50 4065.92 nM 10.6019/CHEMBL1201861
Homo sapiens DOHH-2 IC50 74951.41 nM 10.6019/CHEMBL1201861
Homo sapiens DSH1 IC50 52.89 nM 10.6019/CHEMBL1201861
Homo sapiens DSH1 IC50 757.92 nM 10.6019/CHEMBL1201861
Homo sapiens DU-4475 IC50 196.58 nM 10.6019/CHEMBL1201861
Homo sapiens DU-4475 IC50 7579.64 nM 10.6019/CHEMBL1201861
Homo sapiens EB2 IC50 4511.4 nM 10.6019/CHEMBL1201861
Homo sapiens EB2 IC50 13850.48 nM 10.6019/CHEMBL1201861
Homo sapiens EB-3 IC50 5030.41 nM 10.6019/CHEMBL1201861
Homo sapiens EB-3 IC50 12448.5 nM 10.6019/CHEMBL1201861
Homo sapiens ECC12 IC50 2379.4 nM 10.6019/CHEMBL1201861
Homo sapiens ECC4 IC50 5052.73 nM 10.6019/CHEMBL1201861
Homo sapiens ECC4 IC50 93826.94 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 10703.14 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 18073.49 nM 10.6019/CHEMBL1201861
Homo sapiens EHEB IC50 21673.08 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX IC50 1034.42 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX IC50 37394.63 nM 10.6019/CHEMBL1201861
Homo sapiens EM-2 IC50 878.44 nM 10.6019/CHEMBL1201861
Homo sapiens EM-2 IC50 6670.99 nM 10.6019/CHEMBL1201861
Homo sapiens Endo-beta-N-acetylglucosaminidase Inhibition nan % 10.1016/j.bmcl.2017.05.010
Homo sapiens EOL1 IC50 44156.8 nM 10.6019/CHEMBL1201861
Homo sapiens EOL1 IC50 57031.46 nM 10.6019/CHEMBL1201861
Homo sapiens ES1 IC50 1079.21 nM 10.6019/CHEMBL1201861
Homo sapiens ES1 IC50 75194.42 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 4328.24 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 15655.56 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 3061.11 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 6926.52 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 4402.55 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 12110.49 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 13.06 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 330.14 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 896.5 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 19459.96 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 247.63 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 6368.16 nM 10.6019/CHEMBL1201861
Homo sapiens Estrogen receptor alpha Activity nan None 10.1016/j.ejmech.2019.111605
Homo sapiens ETK-1 IC50 28344.56 nM 10.6019/CHEMBL1201861
Homo sapiens ETK-1 IC50 37050.02 nM 10.6019/CHEMBL1201861
Homo sapiens EVSA-T IC50 499.11 nM 10.6019/CHEMBL1201861
Homo sapiens EVSA-T IC50 40016.43 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 210.47 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 4192.55 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 11518.61 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 348122.7 nM 10.6019/CHEMBL1201861
Homo sapiens EW-12 IC50 144698.9 nM 10.6019/CHEMBL1201861
Homo sapiens EW-12 IC50 557847.15 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 22413.49 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 33896.88 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 1313.47 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 2980.23 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 2023.37 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 672665.38 nM 10.6019/CHEMBL1201861
Homo sapiens EW-22 IC50 106189.79 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 32347.35 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 41422.41 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 13825.27 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 94908.09 nM 10.6019/CHEMBL1201861
Homo sapiens Frataxin, mitochondrial Inhibition nan % 10.1021/jm3017199
Homo sapiens GAK IC50 205.34 nM 10.6019/CHEMBL1201861
Homo sapiens GAK IC50 19795.63 nM 10.6019/CHEMBL1201861
Homo sapiens Gamma-secretase subunit PEN-2 IC50 200000.0 nM 10.1021/jm0004897
Homo sapiens GB-1 IC50 721.24 nM 10.6019/CHEMBL1201861
Homo sapiens GB-1 IC50 2884.21 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 5472.36 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 29742.8 nM 10.6019/CHEMBL1201861
Homo sapiens GDM-1 IC50 351.04 nM 10.6019/CHEMBL1201861
Homo sapiens GDM-1 IC50 21046.85 nM 10.6019/CHEMBL1201861
Homo sapiens GI-1 IC50 1471.31 nM 10.6019/CHEMBL1201861
Homo sapiens GI-1 IC50 33781.39 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 193.06 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 59771.74 nM 10.6019/CHEMBL1201861
Homo sapiens GOTO IC50 15826.88 nM 10.6019/CHEMBL1201861
Homo sapiens GOTO IC50 16961.72 nM 10.6019/CHEMBL1201861
Homo sapiens GR-ST IC50 3592.66 nM 10.6019/CHEMBL1201861
Homo sapiens GR-ST IC50 21416.96 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 5176.62 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 17010.49 nM 10.6019/CHEMBL1201861
Homo sapiens HAL-01 IC50 4570.34 nM 10.6019/CHEMBL1201861
Homo sapiens HAL-01 IC50 136429.36 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 1381.7 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 34495.85 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1187 IC50 13834.89 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1187 IC50 77612.23 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1599 IC50 1255.89 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1599 IC50 74873.2 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2157 IC50 2156.77 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2157 IC50 17475.45 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 3469.37 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 4448.12 nM 10.6019/CHEMBL1201861
Homo sapiens HCC 2998 IC50 938.54 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-4 IC50 1302.21 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 2448.83 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 72737.2 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmcl.2019.126822
Homo sapiens HCT-116 IC50 820.0 nM 10.1021/acsmedchemlett.9b00233
Homo sapiens HDLM-2 IC50 20882.09 nM 10.6019/CHEMBL1201861
Homo sapiens HDLM-2 IC50 165957.71 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 233.03 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 22329.42 nM 10.6019/CHEMBL1201861
Homo sapiens Heat shock 70 kDa protein 6 FC 0.71 None 10.1021/jm401279n
Homo sapiens HEK293 Activity nan None 10.1021/acs.jmedchem.6b01885
Homo sapiens HEK-293T FC 332.0 None 10.1021/acs.jnatprod.7b00918
Homo sapiens HEK-293T IC50 nan None 10.1021/acs.jnatprod.7b00918
Homo sapiens HEL IC50 185.17 nM 10.6019/CHEMBL1201861
Homo sapiens HEL IC50 1070.25 nM 10.6019/CHEMBL1201861
Homo sapiens HeLa Activity 5.6 % 10.1016/j.ejmech.2013.11.009
Homo sapiens HeLa IC50 nan None 10.1016/j.bmcl.2008.08.073
Homo sapiens HeLa IC50 nan None 10.1016/j.bmcl.2009.04.103
Homo sapiens HepG2 IC50 relative 500.0 nM 10.6019/EOS300108
Homo sapiens HH IC50 328.97 nM 10.6019/CHEMBL1201861
Homo sapiens HH IC50 570.53 nM 10.6019/CHEMBL1201861
Homo sapiens Histone deacetylase 6 Inhibition -22.47 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 1.08 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 8912.5 nM None
Homo sapiens HL-60 IC50 20196.47 nM 10.6019/CHEMBL1201861
Homo sapiens HL-60 IC50 102900.55 nM 10.6019/CHEMBL1201861
Homo sapiens HOP-62 IC50 109.49 nM 10.6019/CHEMBL1201861
Homo sapiens HOP-62 IC50 36802.1 nM 10.6019/CHEMBL1201861
Homo sapiens Hs-578T IC50 nan None 10.1021/jm800194k
Homo sapiens HT IC50 1700.43 nM 10.6019/CHEMBL1201861
Homo sapiens HT IC50 45700.72 nM 10.6019/CHEMBL1201861
Homo sapiens HT-144 IC50 138.95 nM 10.6019/CHEMBL1201861
Homo sapiens HT-144 IC50 334.22 nM 10.6019/CHEMBL1201861
Homo sapiens Huh-7 IC50 10000.0 nM 10.1021/np070211i
Homo sapiens HuTu80 IC50 6368.97 nM 10.6019/CHEMBL1201861
Homo sapiens HuTu80 IC50 10615.98 nM 10.6019/CHEMBL1201861
Homo sapiens IA-LM IC50 1241.16 nM 10.6019/CHEMBL1201861
Homo sapiens IM-9 IC50 8124.37 nM 10.6019/CHEMBL1201861
Homo sapiens IM-9 IC50 20622.36 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-5 IC50 99758.47 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-5 IC50 181570.5 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MEL1 IC50 9741.98 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MEL1 IC50 58644.22 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 1402.08 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 24238.98 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 200.94 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 1307.54 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL2 IC50 2012.52 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL2 IC50 65010.25 nM 10.6019/CHEMBL1201861
Homo sapiens JAR IC50 31379.91 nM 10.6019/CHEMBL1201861
Homo sapiens JAR IC50 89058.19 nM 10.6019/CHEMBL1201861
Homo sapiens JIYOYE IC50 3820.83 nM 10.6019/CHEMBL1201861
Homo sapiens JIYOYE IC50 9293.17 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 19406.56 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 108329.99 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-2 IC50 1952.09 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-2 IC50 14773.5 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 1939.04 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 113511.6 nM 10.6019/CHEMBL1201861
Homo sapiens K052 IC50 289.9 nM 10.6019/CHEMBL1201861
Homo sapiens K052 IC50 81960.3 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 4261.64 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 12946.2 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 3991.8 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 37086.39 nM 10.6019/CHEMBL1201861
Homo sapiens KALS-1 IC50 465.84 nM 10.6019/CHEMBL1201861
Homo sapiens KALS-1 IC50 1466.58 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-299 IC50 2389.67 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-299 IC50 70444.7 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-422 IC50 2303.93 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-422 IC50 12749.58 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 1040.16 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 51035.94 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 3996.77 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 6847.87 nM 10.6019/CHEMBL1201861
Homo sapiens KE-37 IC50 132.78 nM 10.6019/CHEMBL1201861
Homo sapiens KE-37 IC50 639.42 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 2887.91 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 387778.38 nM 10.6019/CHEMBL1201861
Homo sapiens KGN IC50 1050.45 nM 10.6019/CHEMBL1201861
Homo sapiens KGN IC50 1175.66 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 147.9 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 627.64 nM 10.6019/CHEMBL1201861
Homo sapiens KLE IC50 313.06 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 IC50 854.66 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 IC50 70160.75 nM 10.6019/CHEMBL1201861
Homo sapiens KM-H2 IC50 2290.43 nM 10.6019/CHEMBL1201861
Homo sapiens KM-H2 IC50 3144.13 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 19648.22 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 37223.42 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-PE IC50 3677.23 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-PE IC50 115583.36 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 44.41 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 26817.67 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 303.23 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 2673.82 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-RT-BM-1 IC50 56663.77 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YN IC50 34905.66 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 3621.26 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 139735.73 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 64.58 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 971.75 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 13612.37 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 14090.16 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 1123.74 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 2251.83 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 30543.44 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 91655.13 nM 10.6019/CHEMBL1201861
Homo sapiens L-363 IC50 26616.6 nM 10.6019/CHEMBL1201861
Homo sapiens L-363 IC50 32214.45 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 34753.63 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 44670.8 nM 10.6019/CHEMBL1201861
Homo sapiens L-540 IC50 1118.39 nM 10.6019/CHEMBL1201861
Homo sapiens L-540 IC50 13608.44 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 218.51 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 2456.22 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 313.0 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 3859.26 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 6328.8 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 7722.31 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 142.47 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 870.76 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 37.6 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 27478.97 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 241.98 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 2236.67 nM 10.6019/CHEMBL1201861
Homo sapiens LB647-SCLC IC50 3008.6 nM 10.6019/CHEMBL1201861
Homo sapiens LB647-SCLC IC50 4563.08 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 80.36 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 1072.91 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 193.4 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 476.26 nM 10.6019/CHEMBL1201861
Homo sapiens LB996-RCC IC50 1552.79 nM 10.6019/CHEMBL1201861
Homo sapiens LB996-RCC IC50 40871.62 nM 10.6019/CHEMBL1201861
Homo sapiens LC-1F IC50 1551.98 nM 10.6019/CHEMBL1201861
Homo sapiens LC-1F IC50 4637.84 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 39433.67 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 41711.46 nM 10.6019/CHEMBL1201861
Homo sapiens LC4-1 IC50 436.07 nM 10.6019/CHEMBL1201861
Homo sapiens LC4-1 IC50 747.47 nM 10.6019/CHEMBL1201861
Homo sapiens LNCaP-Clone-FGC IC50 19351.66 nM 10.6019/CHEMBL1201861
Homo sapiens LNCaP-Clone-FGC IC50 29928.1 nM 10.6019/CHEMBL1201861
Homo sapiens LOUCY IC50 254.56 nM 10.6019/CHEMBL1201861
Homo sapiens LOUCY IC50 13756.38 nM 10.6019/CHEMBL1201861
Homo sapiens LOX IMVI IC50 61826.56 nM 10.6019/CHEMBL1201861
Homo sapiens LOX IMVI IC50 88167.55 nM 10.6019/CHEMBL1201861
Homo sapiens LP-1 Activity nan None 10.1158/0008-5472.can-05-0233
Homo sapiens LP-1 IC50 4723.71 nM 10.6019/CHEMBL1201861
Homo sapiens LP-1 IC50 29154.35 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 6556.58 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 17681.8 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 10101.09 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 24901.23 nM 10.6019/CHEMBL1201861
Homo sapiens LS-411N IC50 1698.07 nM 10.6019/CHEMBL1201861
Homo sapiens LS-411N IC50 36991.9 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 667.51 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 25513.58 nM 10.6019/CHEMBL1201861
Homo sapiens LU-134-A IC50 83135.1 nM 10.6019/CHEMBL1201861
Homo sapiens LU-134-A IC50 85940.4 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 12902.64 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 78473.89 nM 10.6019/CHEMBL1201861
Homo sapiens LU-165 IC50 28086.11 nM 10.6019/CHEMBL1201861
Homo sapiens LU-165 IC50 247335.82 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 1127.53 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 17650.62 nM 10.6019/CHEMBL1201861
Homo sapiens LXF-289 cell line IC50 70.66 nM 10.6019/CHEMBL1201861
Homo sapiens LXF-289 cell line IC50 5407.04 nM 10.6019/CHEMBL1201861
Homo sapiens MC116 IC50 8979.4 nM 10.6019/CHEMBL1201861
Homo sapiens MC116 IC50 88871.81 nM 10.6019/CHEMBL1201861
Homo sapiens MC-CAR IC50 2229.5 nM 10.6019/CHEMBL1201861
Homo sapiens MC-CAR IC50 26690.08 nM 10.6019/CHEMBL1201861
Homo sapiens MCF7 Activity nan None 10.1016/j.bmc.2007.01.025
Homo sapiens MCF7 IC50 130.0 nM 10.1016/j.bmcl.2013.09.087
Homo sapiens MCF7 IC50 300.0 nM 10.1021/jm800194k
Homo sapiens MDA-MB-134-VI IC50 6640.33 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-134-VI IC50 148268.38 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-231 IC50 180.0 nM 10.1016/j.bmcl.2013.09.087
Homo sapiens MDA-MB-231 IC50 250.0 nM 10.1021/jm800194k
Homo sapiens MEG-01 IC50 3596.8 nM 10.6019/CHEMBL1201861
Homo sapiens MEG-01 IC50 8881.54 nM 10.6019/CHEMBL1201861
Homo sapiens MFH-ino IC50 111.1 nM 10.6019/CHEMBL1201861
Homo sapiens MFH-ino IC50 1175.01 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 2508.71 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 340485.66 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-CALL-2 IC50 70060.0 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-CALL-2 IC50 230297.97 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 13290.19 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 25950.66 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 7329.29 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 39738.84 nM 10.6019/CHEMBL1201861
Homo sapiens ML-2 IC50 118.06 nM 10.6019/CHEMBL1201861
Homo sapiens ML-2 IC50 473.49 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 2185.76 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 41759.46 nM 10.6019/CHEMBL1201861
Homo sapiens MMAC-SF IC50 72.68 nM 10.6019/CHEMBL1201861
Homo sapiens MMAC-SF IC50 3210.82 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 109689.98 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 167261.42 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 517.62 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 55301.06 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 295.24 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 38994.44 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 IC50 5485.99 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 IC50 18820.79 nM 10.6019/CHEMBL1201861
Homo sapiens MONO-MAC-6 IC50 536.11 nM 10.6019/CHEMBL1201861
Homo sapiens MONO-MAC-6 IC50 718.2 nM 10.6019/CHEMBL1201861
Homo sapiens MPP-89 IC50 3984.06 nM 10.6019/CHEMBL1201861
Homo sapiens MPP-89 IC50 42587.51 nM 10.6019/CHEMBL1201861
Homo sapiens MRK-nu-1 IC50 13194.97 nM 10.6019/CHEMBL1201861
Homo sapiens MRK-nu-1 IC50 45925.34 nM 10.6019/CHEMBL1201861
Homo sapiens MS-1 IC50 239120.59 nM 10.6019/CHEMBL1201861
Homo sapiens MS-1 IC50 327665.74 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 14744.84 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 434623.87 nM 10.6019/CHEMBL1201861
Homo sapiens MV4-11 IC50 8868.01 nM 10.6019/CHEMBL1201861
Homo sapiens MV4-11 IC50 42906.74 nM 10.6019/CHEMBL1201861
Homo sapiens MZ1-PC IC50 6674.0 nM 10.6019/CHEMBL1201861
Homo sapiens MZ1-PC IC50 7865.58 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 175.59 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 8466.77 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 263.74 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 9273.07 nM 10.6019/CHEMBL1201861
Homo sapiens NALM-6 IC50 4925.82 nM 10.6019/CHEMBL1201861
Homo sapiens NALM-6 IC50 6867.54 nM 10.6019/CHEMBL1201861
Homo sapiens NB1 IC50 4841.3 nM 10.6019/CHEMBL1201861
Homo sapiens NB1 IC50 24693.92 nM 10.6019/CHEMBL1201861
Homo sapiens NB10 IC50 7995.56 nM 10.6019/CHEMBL1201861
Homo sapiens NB10 IC50 139732.1 nM 10.6019/CHEMBL1201861
Homo sapiens NB12 IC50 3598.88 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 12978.3 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 30958.42 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 11787.61 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 147081.67 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 429.7 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 106527.91 nM 10.6019/CHEMBL1201861
Homo sapiens NB5 IC50 8232.26 nM 10.6019/CHEMBL1201861
Homo sapiens NB5 IC50 70346.78 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 30950.34 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 135080.65 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 33645.42 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 112332.81 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 5045.89 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 95778.57 nM 10.6019/CHEMBL1201861
Homo sapiens NCCIT IC50 317.83 nM 10.6019/CHEMBL1201861
Homo sapiens NCCIT IC50 2677.95 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1092 IC50 388.44 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1092 IC50 1583.68 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 74936.72 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 414625.62 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H128 IC50 1358.14 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H128 IC50 39556.66 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1299 IC50 38160.31 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1304 IC50 13011.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1304 IC50 21031.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 686.19 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 5638.65 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 35845.86 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 58817.24 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1417 IC50 14322.56 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1417 IC50 180330.63 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1436 IC50 72745.57 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1436 IC50 118867.92 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1522 IC50 13239.36 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1522 IC50 69004.66 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 6238.49 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 9157.16 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 11096.49 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 18637.58 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 4157.97 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 21212.95 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1694 IC50 46810.52 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1694 IC50 71031.97 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 29939.9 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 156279.49 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1838 IC50 24987.83 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1838 IC50 271455.98 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H187 IC50 190064.22 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H187 IC50 428541.25 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1882 IC50 590.36 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1882 IC50 103456.99 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1963 IC50 14100.43 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1963 IC50 26062.28 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2081 IC50 1551.96 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2081 IC50 14578.14 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 5193.52 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 34757.83 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2107 IC50 31233.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 626.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 107635.23 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2141 IC50 1673.17 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2141 IC50 19561.94 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2171 IC50 36984.76 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2171 IC50 79413.63 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2196 IC50 61231.02 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2196 IC50 62293.06 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2227 IC50 1615.61 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 IC50 114376.43 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 IC50 188866.42 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 IC50 480.0 nM 10.1021/acs.jmedchem.8b01943
Homo sapiens NCI-H23 IC50 1204.1 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 IC50 6108.75 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H322M IC50 78370.92 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H322M IC50 452677.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H345 IC50 21064.33 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H345 IC50 246503.45 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H446 IC50 54309.17 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H446 IC50 99758.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H510A IC50 127319.54 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H510A IC50 135851.58 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H524 IC50 11982.19 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H524 IC50 23894.16 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 78587.68 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 312684.91 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H64 IC50 18944.01 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H64 IC50 40094.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 IC50 151.41 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 IC50 8792.01 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H716 IC50 82907.54 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H716 IC50 259637.39 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H719 IC50 1274.11 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H719 IC50 4362.65 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 10219.8 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 98406.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H727 IC50 980.0 nM 10.1021/acs.jmedchem.8b01943
Homo sapiens NCI-H747 IC50 371.03 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H747 IC50 712.74 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H748 IC50 3442.66 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H748 IC50 4907.37 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 71950.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 240731.21 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H889 IC50 104242.2 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H889 IC50 209602.11 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-N87 IC50 13735.98 nM 10.6019/CHEMBL1201861
Homo sapiens NEC8 IC50 119.95 nM 10.6019/CHEMBL1201861
Homo sapiens NEC8 IC50 51178.01 nM 10.6019/CHEMBL1201861
Homo sapiens NF-kappaB inhibitor alpha EC50 1000.0 nM 10.1016/j.bmcl.2007.10.100
Homo sapiens NF-kappaB inhibitor alpha EC50 5200.0 nM 10.1016/j.bmcl.2007.10.100
Homo sapiens NF-kappaB inhibitor alpha Efficacy 100.0 % 10.1016/j.bmcl.2007.10.100
Homo sapiens NH-12 IC50 10243.25 nM 10.6019/CHEMBL1201861
Homo sapiens NH-12 IC50 316901.18 nM 10.6019/CHEMBL1201861
Homo sapiens NKM-1 IC50 3773.78 nM 10.6019/CHEMBL1201861
Homo sapiens NKM-1 IC50 10598.06 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 1189.54 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 6718.95 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 89.09 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 608.13 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 2031.04 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 5169.13 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 5992.28 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 7242.54 nM 10.6019/CHEMBL1201861
Homo sapiens NOS-1 IC50 5851.94 nM 10.6019/CHEMBL1201861
Homo sapiens NOS-1 IC50 12034.53 nM 10.6019/CHEMBL1201861
Homo sapiens NTERA-2-cl-D1 IC50 57.72 nM 10.6019/CHEMBL1201861
Homo sapiens NTERA-2-cl-D1 IC50 425.92 nM 10.6019/CHEMBL1201861
Homo sapiens Nuclear factor NF-kappa-B p65 subunit Efficacy 90.0 % 10.1016/j.bmcl.2007.10.100
Homo sapiens Nuclear factor NF-kappa-B p65 subunit IC50 nan None 10.1016/j.bmcl.2007.10.100
Homo sapiens OCI-AML2 IC50 7003.26 nM 10.6019/CHEMBL1201861
Homo sapiens OCI-AML2 IC50 86860.73 nM 10.6019/CHEMBL1201861
Homo sapiens OCUB-M IC50 37.37 nM 10.6019/CHEMBL1201861
Homo sapiens OCUB-M IC50 15337.64 nM 10.6019/CHEMBL1201861
Homo sapiens OMC-1 IC50 2150.65 nM 10.6019/CHEMBL1201861
Homo sapiens OMC-1 IC50 8521.91 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 129.35 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 899.04 nM 10.6019/CHEMBL1201861
Homo sapiens OPM-2 IC50 104.74 nM 10.6019/CHEMBL1201861
Homo sapiens OPM-2 IC50 758.37 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 479.72 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 58684.05 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-4 IC50 109.38 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-4 IC50 34065.05 nM 10.6019/CHEMBL1201861
Homo sapiens P30-OHK IC50 7212.82 nM 10.6019/CHEMBL1201861
Homo sapiens P30-OHK IC50 283847.47 nM 10.6019/CHEMBL1201861
Homo sapiens P31-FUJ IC50 20475.29 nM 10.6019/CHEMBL1201861
Homo sapiens P31-FUJ IC50 41048.49 nM 10.6019/CHEMBL1201861
Homo sapiens p53-binding protein Mdm-2 FC 2.9 None 10.1021/acs.jmedchem.8b00909
Homo sapiens p53-binding protein Mdm-2 FC 6.9 None 10.1021/acs.jmedchem.8b00909
Homo sapiens PC-3 FC 0.255 None 10.1038/nchembio790
Homo sapiens PC-3 IC50 600.0 nM 10.1021/jm058289o
Homo sapiens PF-382 IC50 167.06 nM 10.6019/CHEMBL1201861
Homo sapiens PF-382 IC50 583.79 nM 10.6019/CHEMBL1201861
Homo sapiens Proteasome component C5 Activity nan None 10.1016/j.bmcl.2008.08.073
Homo sapiens Proteasome component C5 IC50 44.0 nM 10.1016/j.bmcl.2016.04.067
Homo sapiens Proteasome component C5 IC50 120.0 nM 10.1016/j.ejmech.2013.11.009
Homo sapiens Proteasome component C5 IC50 120.0 nM 10.1021/acs.jmedchem.0c01640
Homo sapiens Proteasome component C5 IC50 500.0 nM 10.1016/j.bmc.2019.115161
Homo sapiens Proteasome component C5 IC50 600.0 nM 10.1021/jm4002007
Homo sapiens Proteasome component C5 IC50 1450.0 nM 10.1021/acsmedchemlett.9b00233
Homo sapiens Proteasome component C5 IC50 nan None 10.1016/j.ejmech.2016.11.024
Homo sapiens Proteasome component C5 Inhibition 18.39 % 10.1016/j.ejmech.2020.112890
Homo sapiens Proteasome component C5 Inhibition nan % 10.1016/j.ejmech.2013.11.009
Homo sapiens Proteasome component C5 Ki 130.0 nM 10.1016/j.bmcl.2017.12.053
Homo sapiens Proteasome component C5 Ki 130.0 nM 10.1016/j.bmcl.2021.128478
Homo sapiens Proteasome component C5 Ki 470.0 nM 10.1021/jm058289o
Homo sapiens Proteasome component C5 Ki 5520.0 nM 10.1016/j.ejmech.2016.05.049
Homo sapiens Proteasome component C5 Ki 22100.0 nM 10.1016/j.bmcl.2017.12.053
Homo sapiens Proteasome component C5 Ki 22100.0 nM 10.1016/j.bmcl.2021.128478
Homo sapiens Proteasome Macropain subunit IC50 52.0 nM 10.1016/j.bmcl.2016.04.067
Homo sapiens Proteasome Macropain subunit IC50 1080.0 nM 10.1021/acs.jmedchem.0c01640
Homo sapiens Proteasome Macropain subunit IC50 1600.0 nM 10.1016/j.bmc.2019.115161
Homo sapiens Proteasome Macropain subunit IC50 2100.0 nM 10.1016/j.ejmech.2013.11.009
Homo sapiens Proteasome Macropain subunit IC50 4590.0 nM 10.1021/acsmedchemlett.9b00233
Homo sapiens Proteasome Macropain subunit IC50 nan None 10.1016/j.ejmech.2016.11.024
Homo sapiens Proteasome Macropain subunit Inhibition 51.42 % 10.1016/j.ejmech.2020.112890
Homo sapiens Proteasome Macropain subunit Inhibition nan % 10.1016/j.ejmech.2013.11.009
Homo sapiens Proteasome Macropain subunit Ki 1.0 nM 10.1016/j.bmcl.2017.12.053
Homo sapiens Proteasome Macropain subunit Ki 1.0 nM 10.1016/j.bmcl.2021.128478
Homo sapiens Proteasome Macropain subunit Ki 330.0 nM 10.1021/jm058289o
Homo sapiens Proteasome Macropain subunit Ki 5520.0 nM 10.1016/j.bmcl.2017.12.053
Homo sapiens Proteasome Macropain subunit Ki 5520.0 nM 10.1016/j.bmcl.2021.128478
Homo sapiens Proteasome Macropain subunit Ki 22100.0 nM 10.1016/j.ejmech.2016.05.049
Homo sapiens Proteasome Macropain subunit MB1 Activity nan None 10.1016/j.bmcl.2008.08.073
Homo sapiens Proteasome Macropain subunit MB1 IC50 1.2 nM 10.1016/j.bmc.2018.12.022
Homo sapiens Proteasome Macropain subunit MB1 IC50 1.2 nM 10.1021/acs.jmedchem.0c01640
Homo sapiens Proteasome Macropain subunit MB1 IC50 7.0 nM 10.1021/acsmedchemlett.9b00233
Homo sapiens Proteasome Macropain subunit MB1 IC50 9.0 nM 10.1021/jm4002007
Homo sapiens Proteasome Macropain subunit MB1 IC50 11.0 nM 10.1016/j.ejmech.2013.11.009
Homo sapiens Proteasome Macropain subunit MB1 IC50 25.0 nM 10.1016/j.ejmech.2016.11.024
Homo sapiens Proteasome Macropain subunit MB1 IC50 30.0 nM 10.1016/j.bmc.2019.115161
Homo sapiens Proteasome Macropain subunit MB1 IC50 37.0 nM 10.1016/j.bmcl.2016.04.067
Homo sapiens Proteasome Macropain subunit MB1 Inhibition 38.23 % 10.1016/j.ejmech.2020.112890
Homo sapiens Proteasome Macropain subunit MB1 Inhibition nan % 10.1016/j.ejmech.2013.11.009
Homo sapiens Proteasome Macropain subunit MB1 Ki 1.4 nM 10.1016/j.bmcl.2021.128478
Homo sapiens Proteasome Macropain subunit MB1 Ki 1.4 nM 10.1016/j.ejmech.2016.05.049
Homo sapiens Proteasome Macropain subunit MB1 Ki 3.7 nM 10.1021/jm058289o
Homo sapiens Proteasome Macropain subunit MB1 Ki 4.0 nM 10.1016/j.bmcl.2017.12.053
Homo sapiens Proteasome Macropain subunit MB1 Ki 70.0 nM 10.1016/j.bmcl.2017.12.053
Homo sapiens Proteasome Macropain subunit MB1 Ratio 160.0 None 10.1021/jm058289o
Homo sapiens PSN1 IC50 1270.16 nM 10.6019/CHEMBL1201861
Homo sapiens PSN1 IC50 5909.45 nM 10.6019/CHEMBL1201861
Homo sapiens QIMR-WIL IC50 2167.62 nM 10.6019/CHEMBL1201861
Homo sapiens QIMR-WIL IC50 8133.37 nM 10.6019/CHEMBL1201861
Homo sapiens Raji IC50 1418.5 nM 10.6019/CHEMBL1201861
Homo sapiens Raji IC50 1465.31 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos-2G6-4C10 IC50 34299.27 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos-2G6-4C10 IC50 46566.06 nM 10.6019/CHEMBL1201861
Homo sapiens RCC10RGB IC50 26548.57 nM 10.6019/CHEMBL1201861
Homo sapiens RCC10RGB IC50 38208.27 nM 10.6019/CHEMBL1201861
Homo sapiens REH IC50 47879.34 nM 10.6019/CHEMBL1201861
Homo sapiens REH IC50 236626.04 nM 10.6019/CHEMBL1201861
Homo sapiens RH-1 IC50 3387.48 nM 10.6019/CHEMBL1201861
Homo sapiens RH-1 IC50 61269.67 nM 10.6019/CHEMBL1201861
Homo sapiens RKO IC50 931.76 nM 10.6019/CHEMBL1201861
Homo sapiens RKO IC50 5234.22 nM 10.6019/CHEMBL1201861
Homo sapiens RL IC50 5375.41 nM 10.6019/CHEMBL1201861
Homo sapiens RL IC50 38681.75 nM 10.6019/CHEMBL1201861
Homo sapiens RL95-2 IC50 8108.42 nM 10.6019/CHEMBL1201861
Homo sapiens RL95-2 IC50 29563.75 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-6666 IC50 1858.97 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-6666 IC50 21360.19 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 IC50 423.1 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 IC50 84210.7 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI 8402 IC50 8279.28 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI 8402 IC50 58952.56 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8866 IC50 74750.88 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8866 IC50 134232.32 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 955.67 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 82250.54 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 IC50 250.15 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 IC50 44733.11 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-1 IC50 42180.63 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-1 IC50 79700.83 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 3593.26 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 72339.98 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-3 IC50 2479.55 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-3 IC50 3108.48 nM 10.6019/CHEMBL1201861
Homo sapiens SCH IC50 14161.46 nM 10.6019/CHEMBL1201861
Homo sapiens SCH IC50 60963.79 nM 10.6019/CHEMBL1201861
Homo sapiens SCLC-21H IC50 10659.64 nM 10.6019/CHEMBL1201861
Homo sapiens SCLC-21H IC50 69628.57 nM 10.6019/CHEMBL1201861
Homo sapiens SF-126 IC50 989.71 nM 10.6019/CHEMBL1201861
Homo sapiens SF-126 IC50 27688.33 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 IC50 656.41 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 IC50 56404.28 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 IC50 38670.46 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 IC50 192728.22 nM 10.6019/CHEMBL1201861
Homo sapiens SH-4 IC50 43.1 nM 10.6019/CHEMBL1201861
Homo sapiens SH-4 IC50 605.09 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 7224.3 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 39772.19 nM 10.6019/CHEMBL1201861
Homo sapiens SIG-M5 IC50 30795.21 nM 10.6019/CHEMBL1201861
Homo sapiens SIG-M5 IC50 82959.62 nM 10.6019/CHEMBL1201861
Homo sapiens SIMA IC50 5307.65 nM 10.6019/CHEMBL1201861
Homo sapiens SIMA IC50 312027.71 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 9090.91 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 9529.51 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LMS-1 IC50 193.03 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LMS-1 IC50 60428.21 nM 10.6019/CHEMBL1201861
Homo sapiens SKM-1 IC50 3713.76 nM 10.6019/CHEMBL1201861
Homo sapiens SKM-1 IC50 9618.24 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 66829.93 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 118008.54 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 IC50 8557.4 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 IC50 63989.24 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MM-2 IC50 11806.1 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MM-2 IC50 75846.15 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-DZ IC50 7710.89 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-DZ IC50 17164.37 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 18702.33 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 75075.4 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 6458.54 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 67970.04 nM 10.6019/CHEMBL1201861
Homo sapiens SK-PN-DW IC50 231.9 nM 10.6019/CHEMBL1201861
Homo sapiens SK-PN-DW IC50 29212.95 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 220.49 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 25185.06 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-75 IC50 3601.03 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-75 IC50 7205.88 nM 10.6019/CHEMBL1201861
Homo sapiens SNU1 IC50 10496.88 nM 10.6019/CHEMBL1201861
Homo sapiens SNU1 IC50 201086.87 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 IC50 38565.34 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 IC50 40777.11 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-5 IC50 695.45 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-5 IC50 2070.59 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C1 IC50 12651.74 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C1 IC50 31312.61 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C2B IC50 707.39 nM 10.6019/CHEMBL1201861
Homo sapiens SR IC50 4300.2 nM 10.6019/CHEMBL1201861
Homo sapiens SR IC50 11018.49 nM 10.6019/CHEMBL1201861
Homo sapiens ST486 IC50 13314.68 nM 10.6019/CHEMBL1201861
Homo sapiens ST486 IC50 25111.33 nM 10.6019/CHEMBL1201861
Homo sapiens SU-DHL-1 IC50 1712.81 nM 10.6019/CHEMBL1201861
Homo sapiens SU-DHL-1 IC50 28941.54 nM 10.6019/CHEMBL1201861
Homo sapiens SUP-T1 IC50 143708.22 nM 10.6019/CHEMBL1201861
Homo sapiens SUP-T1 IC50 243062.35 nM 10.6019/CHEMBL1201861
Homo sapiens Survival motor neuron protein Potency 891.3 nM None
Homo sapiens SW684 IC50 1286.59 nM 10.6019/CHEMBL1201861
Homo sapiens SW684 IC50 182570.43 nM 10.6019/CHEMBL1201861
Homo sapiens SW872 IC50 657.29 nM 10.6019/CHEMBL1201861
Homo sapiens SW872 IC50 2600.22 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 47412.84 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 78068.84 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 15886.6 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 54835.73 nM 10.6019/CHEMBL1201861
Homo sapiens SW982 IC50 2514.8 nM 10.6019/CHEMBL1201861
Homo sapiens TALL-1 IC50 26508.51 nM 10.6019/CHEMBL1201861
Homo sapiens TALL-1 IC50 198303.76 nM 10.6019/CHEMBL1201861
Homo sapiens TC-YIK IC50 50036.31 nM 10.6019/CHEMBL1201861
Homo sapiens TE-1 IC50 451.19 nM 10.6019/CHEMBL1201861
Homo sapiens TE-1 IC50 20891.53 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 964.3 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 46491.52 nM 10.6019/CHEMBL1201861
Homo sapiens TE-11 IC50 34482.23 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 13699.37 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 15193.84 nM 10.6019/CHEMBL1201861
Homo sapiens TE-15 IC50 1923.73 nM 10.6019/CHEMBL1201861
Homo sapiens TE-15 IC50 18981.47 nM 10.6019/CHEMBL1201861
Homo sapiens TE-441-T IC50 40760.07 nM 10.6019/CHEMBL1201861
Homo sapiens TE-441-T IC50 199738.9 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 142.78 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 1839.01 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 3945.61 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 71626.63 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 270.09 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 342.79 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 610.33 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 20045.87 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC1TKB IC50 686.42 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC1TKB IC50 11410.17 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC24TKB IC50 62149.14 nM 10.6019/CHEMBL1201861
Homo sapiens TGW IC50 6455.93 nM 10.6019/CHEMBL1201861
Homo sapiens TGW IC50 84686.65 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 IC50 4048.35 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 IC50 264738.09 nM 10.6019/CHEMBL1201861
Homo sapiens TK-10 IC50 254.35 nM 10.6019/CHEMBL1201861
Homo sapiens TK-10 IC50 1283.97 nM 10.6019/CHEMBL1201861
Homo sapiens TUR IC50 10822.2 nM 10.6019/CHEMBL1201861
Homo sapiens TUR IC50 167869.69 nM 10.6019/CHEMBL1201861
Homo sapiens U-266 IC50 6519.26 nM 10.6019/CHEMBL1201861
Homo sapiens U-266 IC50 146560.89 nM 10.6019/CHEMBL1201861
Homo sapiens U-698-M IC50 7859.92 nM 10.6019/CHEMBL1201861
Homo sapiens U-698-M IC50 68568.69 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 19630.69 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 26764.38 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-257 IC50 119.27 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-257 IC50 4514.54 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-812 IC50 69520.94 nM 10.6019/CHEMBL1201861
Homo sapiens VA-ES-BJ IC50 222.57 nM 10.6019/CHEMBL1201861
Homo sapiens VA-ES-BJ IC50 3963.69 nM 10.6019/CHEMBL1201861
Homo sapiens VHL/FLT3 Activity nan None 10.1016/j.bmcl.2022.129041
Homo sapiens VHL/Vascular endothelial growth factor receptor 2 Activity nan None 10.1016/j.ejmech.2022.114821
Homo sapiens Vitamin D receptor Potency 39810.7 nM None
Homo sapiens WSU-NHL IC50 14637.33 nM 10.6019/CHEMBL1201861
Homo sapiens WSU-NHL IC50 109671.44 nM 10.6019/CHEMBL1201861
Homo sapiens YT IC50 4354.24 nM 10.6019/CHEMBL1201861
Homo sapiens YT IC50 9836.73 nM 10.6019/CHEMBL1201861
Human immunodeficiency virus type 1 group M subtype B (isolate NY5)(HIV-1) Virion infectivity factor Inhibition nan % 10.1021/acs.jmedchem.0c00940
Mus musculus RAW264.7 Activity nan None 10.1021/np400190n
Mus musculus RAW264.7 IC50 0.08 ug.mL-1 10.1016/j.bmcl.2015.08.057
Mus musculus RAW264.7 IC50 0.17 ug.mL-1 10.1016/j.bmcl.2011.12.114
Mus musculus RAW264.7 IC50 80.0 nM 10.1021/np200912p
Mus musculus RAW264.7 IC50 100.0 nM 10.1016/j.bmc.2020.115971
Mus musculus RAW264.7 IC50 100.0 nM 10.1021/np400190n
Mus musculus RAW264.7 IC50 100.0 nM 10.1021/np400669t
Mus musculus RAW264.7 IC50 100.0 nM 10.1021/np400971r
Mus musculus RAW264.7 IC50 100.0 nM 10.1021/np4010135
Mus musculus RAW264.7 IC50 150.0 nM 10.1021/acs.jnatprod.5b00802
Mus musculus RAW264.7 IC50 150.0 nM 10.1021/np300772e
Mus musculus RAW264.7 IC50 160.0 nM 10.1021/acs.jnatprod.8b00460
Mus musculus RAW264.7 IC50 200.0 nM 10.1016/j.ejmech.2021.113165
Mus musculus RAW264.7 IC50 200.0 nM 10.1021/acs.jnatprod.7b00150
Mus musculus RAW264.7 IC50 350.0 nM 10.1016/j.bmc.2010.10.019
Mus musculus RAW264.7 IC50 439.0 nM 10.1021/np200146x
Mus musculus RAW264.7 IC50 630.0 nM 10.1016/j.bmc.2012.06.055
Mus musculus RAW264.7 IC50 2600.0 nM 10.1021/acs.jnatprod.2c00530
Plasmodium falciparum Plasmodium falciparum IC50 35.0 nM 10.1016/j.bmc.2018.12.022
Rattus norvegicus Nuclear factor erythroid 2-related factor 2 Activity nan None 10.1021/acs.jmedchem.1c02210
Rattus norvegicus PC-12 Activity nan None 10.1074/jbc.m603712200
Rattus norvegicus Plasma Stability nan % 10.1021/jm058289o
Schistosoma mansoni Schistosoma mansoni In vitro activity nan None 10.6019/CHEMBL5096127
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab IC50 3899.42 nM 10.1016/j.bmc.2020.115860
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab IC50 3900.0 nM 10.1016/j.bmc.2020.115860
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab IC50 3900.0 nM 10.1016/j.bmcl.2021.128263
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab IC50 7400.0 nM 10.1021/acs.jmedchem.2c01005
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab IC50 10000.0 nM 10.1016/j.bmcl.2021.128263
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab IC50 relative 20.0 uM 10.6019/EOS300041
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab IC50 relative 20.0 uM 10.6019/EOS300044
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 28.45 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 54.48 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 99.0 % 10.1016/j.bmcl.2022.128732
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 320.0 nM 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 990.0 nM 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 relative 4.466 uM 10.6019/EOS300033
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -11.44 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 13.29 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 15.12 % 10.6019/CHEMBL4495565
Sus scrofa Calpain 2 IC50 nan None 10.1016/j.bmc.2018.12.022
None ADMET IC50 290.0 nM 10.1016/j.bmcl.2013.09.087
None ADMET IC50 10000.0 nM 10.1021/np070211i
None ADMET Selectivity index 3.07 None 10.6019/CHEMBL4495565
None ADMET Selectivity index 9.06 None 10.6019/CHEMBL4495565
None BC1 cell line IC50 3242.87 nM 10.6019/CHEMBL1201861
None BC1 cell line IC50 5004.47 nM 10.6019/CHEMBL1201861
None NON-PROTEIN TARGET IC50 77.0 nM 10.1016/j.ejmech.2011.07.037
None NON-PROTEIN TARGET IC50 77.0 nM 10.1021/jm050181l
None NON-PROTEIN TARGET IC50 170.0 nM 10.1021/jm401279n
None NON-PROTEIN TARGET IC50 180.0 nM 10.1021/acs.jnatprod.6b00206
None NON-PROTEIN TARGET IC50 10000.0 nM 10.1016/j.bmcl.2007.10.100
None NON-PROTEIN TARGET IC50 12300.0 nM 10.1016/j.ejmech.2016.05.049
None No relevant target Solubility nan None 10.1021/jm058289o
None Proteasome Inhibition nan % 10.1021/acs.jmedchem.9b00144
None Proteasome Inhibition nan % 10.1021/acs.jnatprod.9b00826
None Proteasome Inhibition nan % None
None Proteasome Ki 4.0 nM 10.1016/s0960-894x(98)00029-8
None Proteasome Ki 4.0 nM 10.1016/s0960-894x(98)00030-4
None Proteasome T1/2 2.0 hr 10.1021/acs.jmedchem.9b00726
None Proteasome T1/2 24.0 hr 10.1021/acs.jmedchem.9b00726
None Unchecked Activity 12.0 % 10.1021/jm901619n
None Unchecked Activity 14.0 % 10.1021/jm901619n
None Unchecked Activity 15.0 % 10.1021/jm901619n
None Unchecked Activity 19.0 % 10.1021/jm901619n
None Unchecked Activity 20.0 % 10.1016/j.ejmech.2013.01.040
None Unchecked Activity 20.0 % 10.1021/jm901619n
None Unchecked Activity 25.0 % 10.1021/jm901619n
None Unchecked Activity 29.0 % 10.1021/jm901619n
None Unchecked Activity 32.0 % 10.1021/jm901619n
None Unchecked Activity 35.0 % 10.1021/jm901619n
None Unchecked Activity 37.0 % 10.1021/jm901619n
None Unchecked Activity 44.0 % 10.1021/jm901619n
None Unchecked Activity 50.0 % 10.1021/jm901619n
None Unchecked Activity 60.0 % 10.1021/jm901619n
None Unchecked Activity 71.0 % 10.1021/jm901619n
None Unchecked Activity 72.0 % 10.1021/jm901619n
None Unchecked Activity 74.0 % 10.1021/jm901619n
None Unchecked Activity 77.0 % 10.1021/jm901619n
None Unchecked Activity 84.0 % 10.1021/jm901619n
None Unchecked Activity 86.0 % 10.1021/jm901619n
None Unchecked Activity 91.0 % 10.1021/jm901619n
None Unchecked Activity 95.0 % 10.1021/jm901619n
None Unchecked Activity nan None 10.1016/j.ejmech.2010.03.023
None Unchecked Activity nan None 10.1021/jm0700823
None Unchecked Activity nan None 10.1021/jm800194k
None Unchecked FC 10.0 None 10.1021/jm800194k
None Unchecked IC50 2.0 nM 10.1016/j.bmc.2009.06.025
None Unchecked IC50 2.0 nM 10.1016/j.bmcl.2008.02.016
None Unchecked IC50 2.0 nM 10.1016/j.ejmech.2007.10.002
None Unchecked IC50 2.0 nM 10.1021/jm100122e
None Unchecked IC50 5.0 nM 10.1016/j.bmcl.2009.02.046
None Unchecked IC50 11.0 nM 10.1016/j.bmcl.2008.08.073
None Unchecked IC50 23.0 nM 10.1016/j.bmc.2009.06.025
None Unchecked IC50 70.0 nM 10.1016/j.bmcl.2009.04.103
None Unchecked IC50 120.0 nM 10.1016/j.bmc.2018.12.022
None Unchecked IC50 120.0 nM 10.1016/j.bmcl.2008.08.073
None Unchecked IC50 311.0 nM 10.1016/j.bmc.2018.12.022
None Unchecked IC50 600.0 nM 10.1016/j.bmcl.2007.10.100
None Unchecked IC50 715.0 nM 10.1016/j.bmcl.2009.08.021
None Unchecked IC50 890.0 nM 10.1021/jm901619n
None Unchecked IC50 911.0 nM 10.1016/j.bmc.2009.06.025
None Unchecked IC50 1077.0 nM 10.1016/j.bmc.2009.06.025
None Unchecked IC50 1077.0 nM 10.1016/j.bmcl.2008.02.016
None Unchecked IC50 1077.0 nM 10.1016/j.ejmech.2007.10.002
None Unchecked IC50 1077.0 nM 10.1021/jm100122e
None Unchecked IC50 1398.0 nM 10.1016/j.bmcl.2009.02.046
None Unchecked IC50 2100.0 nM 10.1016/j.bmcl.2008.08.073
None Unchecked IC50 5460.0 nM 10.1021/jm901619n
None Unchecked IC50 5700.0 nM 10.1021/jm901619n
None Unchecked IC50 7230.0 nM 10.1016/j.bmcl.2009.04.103
None Unchecked IC50 10000.0 nM 10.1016/j.bmc.2009.06.025
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2008.02.016
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2009.02.046
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2009.04.103
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2007.10.002
None Unchecked IC50 10000.0 nM 10.1021/jm100122e
None Unchecked IC50 14400.0 nM 10.1016/j.bmcl.2017.12.053
None Unchecked IC50 29500.0 nM 10.1021/acs.jnatprod.5b00877
None Unchecked IC50 100000.0 nM 10.1021/jm901619n
None Unchecked IC50 104430.0 nM 10.1021/jm901619n
None Unchecked IC50 nan None 10.1021/acs.jnatprod.7b00918
None Unchecked Inhibition 23.0 % 10.1021/acs.jnatprod.5b00877
None Unchecked Inhibition 70.0 % 10.1016/j.bmc.2017.05.009
None Unchecked Inhibition 79.2 % 10.1021/acs.jnatprod.6b00783
None Unchecked Inhibition nan % 10.1016/j.ejmech.2013.11.009
None Unchecked Inhibition nan % 10.1016/j.ejmech.2016.05.049
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.112180
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b01885
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.8b01487
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.5b00877
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.6b00960
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.5b00401
None Unchecked Inhibition nan % 10.1021/jm200285z
None Unchecked Inhibition nan % 10.1021/jm3017199
None Unchecked Inhibition nan % 10.1021/np300231f
None Unchecked Inhibition nan % 10.1038/nchembio790
None Unchecked Ki 0.4 nM 10.1021/jm901619n
None Unchecked Ki 63.5 nM 10.1021/acsmedchemlett.5b00401
None Unchecked Ki 70.0 nM 10.1016/j.bmcl.2021.128478
None Unchecked Ki 75.0 nM 10.1021/jm0701324
None Unchecked Ki 670.0 nM 10.1021/jm0701324
None Unchecked Ki 3700.0 nM 10.1021/acsmedchemlett.5b00401
None Unchecked Ki 4500.0 nM 10.1021/jm0701324
None Unchecked Potency 1258.9 nM None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Ratio IC50 0.004 None 10.1016/j.bmc.2018.12.022
None Unchecked Ratio IC50 2.0 None 10.1021/acs.jmedchem.8b01943
None Unchecked Ratio Ki 4.0 None 10.1021/acsmedchemlett.5b00401
None Unchecked Ratio Ki 10.0 None 10.1021/acsmedchemlett.5b00401

Metabolism Information