| Homo sapiens |
3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
17.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
57.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Actin-related protein 2 |
Activity |
15.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Activin receptor type-1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Activin receptor type-1B |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Activin receptor type-1B |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Activin receptor type-1B |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Adaptor-associated kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
ALK tyrosine kinase receptor |
Activity |
11.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
ALK tyrosine kinase receptor |
Residual Activity |
31.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
ALK tyrosine kinase receptor |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase, alpha-1 subunit |
Activity |
27.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
AMP-activated protein kinase, alpha-2 subunit |
Activity |
25.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
AMP-activated protein kinase, AMPK |
Residual Activity |
25.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase, AMPK |
Residual Activity |
66.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BMP-2-inducible protein kinase |
Activity |
0.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Bone morphogenetic protein receptor type-1A |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
BR serine/threonine-protein kinase 1 |
Residual Activity |
15.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 1 |
Residual Activity |
55.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Activity |
30.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Residual Activity |
18.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I alpha |
Activity |
7.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase I alpha |
Residual Activity |
18.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I alpha |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I delta |
Activity |
2.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase I delta |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I delta |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I gamma |
Activity |
11.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II alpha |
Activity |
28.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II beta |
Residual Activity |
40.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II beta |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II delta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II delta |
Residual Activity |
31.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II delta |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II gamma |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II gamma |
Residual Activity |
32.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II gamma |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase IV |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase IV |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM-kinase kinase alpha |
Activity |
33.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
CaM-kinase kinase beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I alpha |
Activity |
25.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I delta |
Activity |
7.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I delta |
Residual Activity |
31.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I delta |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I epsilon |
Activity |
4.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I gamma 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I gamma 1 |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 2 |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 2 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II |
Residual Activity |
34.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Activity |
17.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Residual Activity |
18.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I isoform gamma-3 |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I isoform gamma-3 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK3/cyclin E |
Residual Activity |
43.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK3/cyclin E |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK6/cyclin D3 |
Residual Activity |
33.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK6/cyclin D3 |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK9/cyclin T1 |
Residual Activity |
42.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK9/cyclin T1 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
43.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Activity |
5.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Residual Activity |
52.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Activity |
2.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Residual Activity |
33.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Residual Activity |
60.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
57.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
21.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
59.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
26.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
33.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
70.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
61.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 1 |
Residual Activity |
70.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 1 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 2 |
Activity |
4.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Death-associated protein kinase 2 |
Residual Activity |
64.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 3 |
Activity |
3.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Death-associated protein kinase 3 |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 3 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Discoidin domain-containing receptor 2 |
Residual Activity |
40.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Discoidin domain-containing receptor 2 |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
34.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
44.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
41.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
44.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Activity |
26.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Residual Activity |
46.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity protein kinase CLK3 |
Residual Activity |
45.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK3 |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity protein kinase TTK |
Activity |
15.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity testis-specific protein kinase 1 |
Activity |
12.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificty protein kinase CLK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 1 |
Activity |
3.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 1 |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 1 |
Residual Activity |
9.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Activity |
12.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Residual Activity |
32.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Activity |
8.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Residual Activity |
33.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Residual Activity |
43.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Activity |
2.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Residual Activity |
28.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 6 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Activity |
33.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Residual Activity |
25.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Residual Activity |
54.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Residual Activity |
0.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Residual Activity |
11.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Residual Activity |
19.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 3 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Activity |
29.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Residual Activity |
49.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Eukaryotic translation initiation factor 2-alpha kinase 4 |
Activity |
0.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Activity |
8.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Residual Activity |
5.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Residual Activity |
29.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Activity |
7.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Residual Activity |
10.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 3 |
Activity |
11.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 3 |
Residual Activity |
15.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 3 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Focal adhesion kinase 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Focal adhesion kinase 1 |
Residual Activity |
9.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Focal adhesion kinase 1 |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Residual Activity |
29.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Residual Activity |
64.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 beta |
Residual Activity |
45.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 beta |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 5 |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 5 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 6 |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 6 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 7 |
Residual Activity |
19.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 7 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Hepatocyte growth factor receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Hepatocyte growth factor receptor |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Hepatocyte growth factor receptor |
Residual Activity |
142.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Histone deacetylase 6 |
IC50 |
1967.0 |
nM |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Histone deacetylase 6 |
Inhibition |
10.48 |
% |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Histone deacetylase 6 |
Inhibition |
81.42 |
% |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Histone deacetylase 6 |
Inhibition |
88.8 |
% |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Homeodomain-interacting protein kinase 1 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 1 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 2 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 2 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 3 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 3 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
13.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
45.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
IC50 |
18.0 |
nM |
10.1016/j.bmc.2009.02.041 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
IC50 |
18.0 |
nM |
10.1021/np070290y |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
IC50 |
19.5 |
nM |
10.1021/jm8011036 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
IC50 |
19.95 |
nM |
10.1016/j.bmcl.2011.02.107 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Inhibition |
89.07 |
% |
10.1016/j.ejmech.2013.01.045 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Inhibition |
nan |
% |
10.1021/np200343t |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
8.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
12.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Activity |
19.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
19.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
32.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
65.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Activity |
13.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
12.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
17.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
55.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
56.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor-related protein |
Activity |
13.95 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Insulin receptor-related protein |
Residual Activity |
3.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor-related protein |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interferon-induced, double-stranded RNA-activated protein kinase |
IC50 |
250.0 |
nM |
10.1016/j.bmcl.2011.04.149 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
49.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
9.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
46.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Leukocyte tyrosine kinase receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
LIM domain kinase 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
LIM domain kinase 1 |
Residual Activity |
7.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
LIM domain kinase 1 |
Residual Activity |
46.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
LIM domain kinase 2 |
Activity |
3.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Lysyl-tRNA synthetase |
Activity |
10.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Activity |
0.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Residual Activity |
2.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Residual Activity |
11.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage-stimulating protein receptor |
Residual Activity |
56.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage-stimulating protein receptor |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 2 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 2 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 3 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 5 |
Residual Activity |
58.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 5 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK1 |
Activity |
13.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase ERK1 |
Residual Activity |
38.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK1 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase ERK2 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK2 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase p38 alpha |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 alpha |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase p38 beta |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 beta |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 delta |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 delta |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 gamma |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase p38 gamma |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 gamma |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Activity |
24.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Activity |
19.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
28.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Maternal embryonic leucine zipper kinase |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Maternal embryonic leucine zipper kinase |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MDA-MB-231 |
GI |
nan |
None |
10.1021/acs.jmedchem.6b00400 |
| Homo sapiens |
Menin/Histone-lysine N-methyltransferase MLL |
Potency |
15848.9 |
nM |
None |
| Homo sapiens |
Misshapen-like kinase 1 |
Residual Activity |
47.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Misshapen-like kinase 1 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 11 |
Activity |
13.25 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Activity |
15.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
8.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
48.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
8.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
48.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
1.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
9.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 1 |
Activity |
9.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
5.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
25.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 4 |
Activity |
19.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
15.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
62.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Activity |
17.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Residual Activity |
31.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myotonin-protein kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Myotonin-protein kinase |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myotonin-protein kinase |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Activity |
20.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Residual Activity |
1.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Residual Activity |
8.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Activity |
11.65 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
2.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Non-receptor tyrosine-protein kinase TNK1 |
Activity |
16.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
NT-3 growth factor receptor |
Activity |
27.95 |
% |
10.1021/jm8011036 |
| Homo sapiens |
NUAK family SNF1-like kinase 1 |
Residual Activity |
13.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
NUAK family SNF1-like kinase 1 |
Residual Activity |
29.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Activity |
21.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Activity |
19.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Residual Activity |
20.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Residual Activity |
41.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Activity |
1.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Residual Activity |
55.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Protein kinase C alpha |
Residual Activity |
54.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C alpha |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C delta |
Residual Activity |
31.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C delta |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C epsilon |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C epsilon |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C eta |
Inhibition |
nan |
% |
10.1021/jm201265f |
| Homo sapiens |
Protein kinase C eta |
Residual Activity |
60.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C eta |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C gamma |
Residual Activity |
33.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C gamma |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C iota |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C iota |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C mu |
Residual Activity |
29.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C mu |
Residual Activity |
58.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C theta |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C theta |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C zeta |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C zeta |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase N2 |
Activity |
8.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Protein kinase N2 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase N2 |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Activity |
27.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Residual Activity |
10.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Residual Activity |
56.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Activity |
24.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
9.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
54.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Pyruvate dehydrogenase kinase isoform 1 |
Activity |
15.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-2 |
Activity |
20.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
59.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 1 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 1 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 2 |
Residual Activity |
53.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 2 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase 1 |
Residual Activity |
39.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase 1 |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Activity |
10.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
33.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
7.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
30.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
9.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
33.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Activity |
13.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Activity |
20.25 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
46.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
12.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
32.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Activity |
33.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Residual Activity |
12.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Residual Activity |
51.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 16 |
Activity |
3.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Activity |
1.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Residual Activity |
39.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 17B |
Activity |
1.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 2 |
Activity |
6.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Activity |
17.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Residual Activity |
38.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 25 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 32B |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 32C |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Residual Activity |
63.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 38-like |
Activity |
30.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT3 |
Residual Activity |
55.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT3 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Activity |
13.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Residual Activity |
3.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Residual Activity |
32.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Activity |
4.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Inhibition |
25.0 |
% |
10.1021/jm201265f |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Residual Activity |
1.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Residual Activity |
2.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Activity |
1.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Inhibition |
25.0 |
% |
10.1021/jm201265f |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Residual Activity |
3.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Residual Activity |
9.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase B-raf |
Activity |
28.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Chk1 |
Residual Activity |
7.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk1 |
Residual Activity |
37.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk2 |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk2 |
Residual Activity |
34.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase D2 |
Residual Activity |
64.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase D2 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase DCLK2 |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase DCLK2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase EEF2K |
Residual Activity |
38.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase EEF2K |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase GAK |
Activity |
0.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase haspin |
Residual Activity |
51.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase haspin |
Residual Activity |
63.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Residual Activity |
17.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Residual Activity |
57.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK beta |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK beta |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Activity |
19.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Residual Activity |
10.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Residual Activity |
28.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST2 |
Activity |
0.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MST2 |
Residual Activity |
8.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST2 |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST4 |
Activity |
7.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek11 |
Residual Activity |
5.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek11 |
Residual Activity |
25.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Residual Activity |
58.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek3 |
Residual Activity |
48.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek3 |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Activity |
27.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK9 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Residual Activity |
61.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 1 |
Activity |
33.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Activity |
15.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Residual Activity |
14.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Residual Activity |
55.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Activity |
28.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Residual Activity |
40.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK7 |
Activity |
18.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK7 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK7 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PCTAIRE-1 |
Activity |
16.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Residual Activity |
43.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Residual Activity |
60.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM3 |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM3 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Residual Activity |
45.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Residual Activity |
70.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK2 |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK4 |
Activity |
1.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Residual Activity |
55.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Residual Activity |
19.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Residual Activity |
54.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase receptor R3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase RIPK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase RIPK2 |
Residual Activity |
29.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RIPK2 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk1 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk1 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk2 |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk2 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk3 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk3 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK1 |
Residual Activity |
5.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK1 |
Residual Activity |
28.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK2 |
Activity |
16.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Activity |
1.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK2 |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK3 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK3 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO1 |
Residual Activity |
8.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO1 |
Residual Activity |
42.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO2 |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO2 |
Residual Activity |
39.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO3 |
Residual Activity |
16.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO3 |
Residual Activity |
61.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TBK1 |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TBK1 |
Residual Activity |
35.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 1 |
Activity |
27.55 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Activity |
22.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK2 |
Residual Activity |
36.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK2 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Activity |
2.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase VRK2 |
Residual Activity |
52.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase VRK2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK2 |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK3 |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK3 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Stem cell growth factor receptor |
Activity |
0.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Stem cell growth factor receptor |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Stem cell growth factor receptor |
Residual Activity |
56.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Suppressor of fused homolog |
Activity |
7.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
62.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
54.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TGF-beta receptor type I |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
TGF-beta receptor type I |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TGF-beta receptor type I |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TRAF2- and NCK-interacting kinase |
Activity |
4.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine- and threonine-specific cdc2-inhibitory kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine kinase non-receptor protein 2 |
Residual Activity |
2.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine kinase non-receptor protein 2 |
Residual Activity |
10.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Residual Activity |
32.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Residual Activity |
63.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Activity |
13.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Residual Activity |
19.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Activity |
4.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Residual Activity |
39.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Residual Activity |
5.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Residual Activity |
18.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Activity |
29.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Residual Activity |
26.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Activity |
10.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Residual Activity |
1.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Residual Activity |
38.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Activity |
8.0 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Residual Activity |
56.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Activity |
10.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Residual Activity |
28.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Residual Activity |
19.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Residual Activity |
63.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Activity |
15.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Residual Activity |
5.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Activity |
11.3 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
7.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
37.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Activity |
3.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Residual Activity |
1.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Residual Activity |
22.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Activity |
0.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Kd |
22.0 |
nM |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Ki |
5.0 |
nM |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Residual Activity |
0.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK3 |
Residual Activity |
5.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK3 |
Residual Activity |
42.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Activity |
9.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
7.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
13.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
29.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Activity |
26.9 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Residual Activity |
1.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Residual Activity |
16.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Activity |
8.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
3.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
22.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Activity |
4.8 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Residual Activity |
1.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Residual Activity |
30.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
41.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Activity |
33.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Activity |
1.1 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Residual Activity |
10.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Residual Activity |
54.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SYK |
Residual Activity |
36.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SYK |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TEC |
Residual Activity |
8.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TEC |
Residual Activity |
49.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Activity |
34.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Residual Activity |
21.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Residual Activity |
12.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Residual Activity |
49.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TYK2 |
Activity |
1.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Activity |
16.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Residual Activity |
38.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosyl-DNA phosphodiesterase 1 |
Potency |
25118.9 |
nM |
None |
| Homo sapiens |
Uncharacterized aarF domain-containing protein kinase 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Activity |
6.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Residual Activity |
2.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Residual Activity |
17.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Activity |
26.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Residual Activity |
41.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Activity |
3.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Residual Activity |
0.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Residual Activity |
4.0 |
% |
10.1042/bj20121418 |
| Schistosoma mansoni |
Schistosoma mansoni |
Activity |
nan |
None |
10.1021/acsmedchemlett.2c00248 |
| Schistosoma mansoni |
Venus kinase receptor 2 |
Kd |
16000.0 |
nM |
10.1021/acsmedchemlett.2c00248 |
| Severe acute respiratory syndrome coronavirus 2 |
Replicase polyprotein 1ab |
Inhibition |
-5.356 |
% |
10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 |
Replicase polyprotein 1ab |
Inhibition |
1.75 |
% |
10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
0.53 |
% |
10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
2.18 |
% |
10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
103.51 |
% |
10.21203/rs.3.rs-23951/v1 |
| None |
ADMET |
Activity |
nan |
None |
10.1021/jm3003922 |
| None |
ADMET |
CL |
3.0 |
mL.min-1.g-1 |
10.6019/CHEMBL3301361 |
| None |
ADMET |
MNTD |
0.5 |
uM |
10.1021/jm3003922 |
| None |
NON-PROTEIN TARGET |
Activity |
nan |
None |
10.1021/jm3003922 |
| None |
No relevant target |
Solubility |
67600.0 |
nM |
10.6019/CHEMBL3301361 |
| None |
Unchecked |
Activity |
2.1 |
% |
10.1021/jm8011036 |
| None |
Unchecked |
Activity |
9.3 |
% |
10.1021/jm8011036 |
| None |
Unchecked |
Activity |
13.55 |
% |
10.1021/jm8011036 |
| None |
Unchecked |
Activity |
21.65 |
% |
10.1021/jm8011036 |
| None |
Unchecked |
Activity |
22.5 |
% |
10.1021/jm8011036 |
| None |
Unchecked |
Activity |
nan |
None |
10.1021/jm8011036 |
| None |
Unchecked |
IC50 |
22.0 |
nM |
10.1021/acs.jnatprod.1c00146 |
| None |
Unchecked |
MOTILITY REDUCTION/CYTOTOXICITY |
33.4 |
% |
10.6019/CHEMBL3988181 |
