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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK323358

Synonym: None

IUPAC Name: (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide

Structure

SMILES: CC[C@H](C)CCCCC(O)=N[C@@H](CCN)C(O)=N[C@H](C(O)=N[C@@H](CCN)C(O)=N[C@H]1CCN=C(O)[C@H]([C@@H](C)O)N=C(O)[C@H](CCN)N=C(O)[C@H](CCN)N=C(O)[C@H](CC(C)C)N=C(O)[C@@H](CC2=CC=CC=C2)N=C(O)[C@H](CCN)N=C1O)[C@@H](C)O

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InChI: InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)/t32-,33+,34+,36-,37-,38-,39-,40-,41-,42-,43+,45-,46-/m0/s1

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InChIKey: WQVJHHACXVLGBL-CTMZAJDNSA-N

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Reference

PubChem CID: 11228650

NPASS: NPC486161

Properties Information

Molecule Weight: 1203.499

TPSA？: 529.0500000000001

MolLogP？: 3.998499999999993

Number of H-Donors: 18

Number of H-Acceptors: 18

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1021/acs.jnatprod.6b00807
Acinetobacter baumannii Acinetobacter baumannii MBC 4.0 mg/L 10.1021/jm400416u
Acinetobacter baumannii Acinetobacter baumannii MBC>99.9 0.25 uM 10.1021/acs.jmedchem.8b01348
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1016/j.bmcl.2020.127163
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.7b01367
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1021/jm400416u
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1021/acs.jnatprod.6b00807
Acinetobacter baumannii Acinetobacter baumannii MIC 0.7 ug.mL-1 10.1021/acs.jmedchem.1c01782
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c00818
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c01469
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1021/jm400416u
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1016/j.bmcl.2020.127163
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1021/acs.jnatprod.2c00621
Acinetobacter baumannii Acinetobacter baumannii MIC 250.0 nM 10.1021/acsmedchemlett.1c00683
Acinetobacter baumannii Acinetobacter baumannii MIC 1000.0 nM 10.1021/acsmedchemlett.1c00683
Acinetobacter baumannii Acinetobacter baumannii MIC 25000.0 nM 10.1021/acs.jmedchem.8b01785
Acinetobacter baumannii Acinetobacter baumannii MIC 32000.0 nM 10.1021/acs.jmedchem.1c00614
Acinetobacter baumannii Acinetobacter baumannii MIC nan None 10.1021/acs.jmedchem.8b01785
Acinetobacter baumannii Acinetobacter baumannii MIC>95 0.25 uM 10.1021/acs.jmedchem.8b01348
Aspergillus flavus Aspergillus flavus MIC 120000.0 nM 10.1016/j.ejmech.2018.05.001
Aspergillus fumigatus Aspergillus fumigatus MIC 120000.0 nM 10.1016/j.ejmech.2018.05.001
Aspergillus niger Aspergillus niger MIC 35.0 ug.mL-1 10.1021/acsmedchemlett.1c00538
Bacillus cereus Bacillus cereus Activity nan None 10.1021/acs.jmedchem.1c01782
Bacillus cereus Bacillus cereus Activity nan None 10.1021/acs.jmedchem.1c01905
Bacillus cereus Bacillus cereus MIC 49170.0 nM 10.1021/acs.jmedchem.6b00922
Bacillus cereus Bacillus cereus MIC nan None 10.1021/acs.jmedchem.2c01469
Bacillus pumilus Bacillus pumilus MIC 49170.0 nM 10.1021/acs.jmedchem.6b00922
Bacillus subtilis Bacillus subtilis Activity nan None 10.1021/acs.jmedchem.1c01782
Bacillus subtilis Bacillus subtilis MIC 2000.0 nM 10.1016/j.ejmech.2021.113433
Bacillus subtilis Bacillus subtilis MIC 4000.0 nM 10.1021/acs.jmedchem.1c02140
Bacillus subtilis Bacillus subtilis MIC 4000.0 nM 10.1021/acs.jmedchem.2c01076
Bacillus subtilis Bacillus subtilis MIC 8000.0 nM 10.1016/j.ejmech.2019.111636
Bacillus subtilis Bacillus subtilis MIC 8000.0 nM 10.1016/j.ejmech.2020.113138
Bacillus subtilis Bacillus subtilis MIC 8000.0 nM 10.1021/acs.jmedchem.1c00614
Bacteria Bacteria MIC 5660.0 nM 10.1021/acs.jmedchem.1c00614
Bacteria Bacteria MIC 12340.0 nM 10.1021/acs.jmedchem.1c00614
Bacteria Bacteria MIC 26910.0 nM 10.1021/acs.jmedchem.1c00614
Bacteria Cell membrane Activity 38.5 % 10.1021/acs.jmedchem.2c01076
Bacteria Cell membrane Activity 45.8 % 10.1021/acs.jmedchem.2c01076
Bacteria Cell membrane Activity 68.0 % 10.1016/j.ejmech.2020.113138
Bacteria Cell membrane Activity 84.8 % 10.1016/j.ejmech.2020.113138
Bacteria Cell membrane Activity nan None 10.1016/j.ejmech.2020.113138
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.1c00614
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.1c01782
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.1c02140
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.2c01076
Bacteria DNA Activity nan None 10.1016/j.ejmech.2019.111636
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1016/j.ejmech.2020.113138
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1016/j.ejmech.2021.113488
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1021/acs.jmedchem.1c00614
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1021/acs.jmedchem.1c02140
Bacteria Lipopolysaccharide (LPS) Inhibition nan % 10.1016/j.ejmech.2020.112580
Candida albicans Candida albicans MIC 35.0 ug.mL-1 10.1021/acsmedchemlett.1c00538
Candida albicans Candida albicans MIC 49170.0 nM 10.1021/acs.jmedchem.6b00922
Candida albicans Candida albicans MIC 100000.0 nM 10.1016/j.ejmech.2018.01.023
Candida albicans Candida albicans MIC 120000.0 nM 10.1016/j.ejmech.2018.05.001
Chlorocebus sabaeus Vero CC50 71.0 ug.mL-1 10.1021/acs.jmedchem.7b01367
Cryptococcus neoformans Cryptococcus neoformans MIC 60000.0 nM 10.1016/j.ejmech.2018.05.001
Enterobacter cloacae Enterobacter cloacae MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.8b00790
Enterobacter sp. Enterobacter sp. MIC 500.0 nM 10.1016/j.ejmech.2021.113433
Enterococcus faecalis Enterococcus faecalis Activity nan None 10.1021/acs.jmedchem.1c01782
Enterococcus faecalis Enterococcus faecalis MIC 8000.0 nM 10.1021/acsmedchemlett.1c00683
Enterococcus faecalis Enterococcus faecalis MIC 64000.0 nM 10.1021/acsmedchemlett.1c00683
Enterococcus faecalis Enterococcus faecalis MIC 128000.0 nM 10.1021/acs.jmedchem.1c00614
Enterococcus faecalis Enterococcus faecalis MIC 128000.0 nM 10.1021/acs.jmedchem.1c02140
Enterococcus faecalis Enterococcus faecalis MIC nan None 10.1021/acs.jmedchem.2c00818
Enterococcus faecalis Enterococcus faecalis MIC nan None 10.1021/acs.jmedchem.2c01469
Enterococcus faecium Enterococcus faecium Activity nan None 10.1021/acs.jmedchem.1c01782
Enterococcus faecium Enterococcus faecium Activity nan None 10.1021/acs.jmedchem.1c01905
Enterococcus faecium Enterococcus faecium MIC nan None 10.1021/acs.jmedchem.2c01469
Enterococcus faecium Enterococcus faecium MIC99 128.0 ug ml-1 10.1021/acs.jmedchem.2c01293
Escherichia coli Escherichia coli Activity 3.47 % 10.1016/j.ejmech.2019.111636
Escherichia coli Escherichia coli Activity 8.49 % 10.1016/j.ejmech.2019.111636
Escherichia coli Escherichia coli Activity 100.0 % 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli Activity nan None 10.1016/j.ejmech.2019.05.075
Escherichia coli Escherichia coli Activity nan None 10.1016/j.ejmech.2019.111636
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.1c01782
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.1c01905
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.2c01469
Escherichia coli Escherichia coli FIC 0.125 None 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli FIC 0.3125 None 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli FIC nan None 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli FICI 0.1875 None 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli FICI 0.25 None 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli FICI 0.3125 None 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli FICI 0.3125 None 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli FICI 0.375 None 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli FICI 0.5625 None 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli FICI 0.625 None 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli FICI 1.25 None 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli MBC 3.1 ug ml-1 10.1021/acs.jmedchem.1c01782
Escherichia coli Escherichia coli MBC 4.0 ug ml-1 10.1021/acs.jmedchem.2c01469
Escherichia coli Escherichia coli MBC>99.9 1.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC>99.9 2.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MBC99.9 4.0 uM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1021/jm400416u
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1016/j.bmcl.2020.127163
Escherichia coli Escherichia coli MIC 0.3 ug.mL-1 10.1021/acs.jnatprod.1c00222
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.ejmech.2020.112276
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.7b01367
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.8b00790
Escherichia coli Escherichia coli MIC 0.7 ug.mL-1 10.1021/acs.jmedchem.1c01782
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.ejmech.2020.112276
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c00818
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c01469
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.7b01367
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.1c00222
Escherichia coli Escherichia coli MIC 1.5 ug.mL-1 10.1021/acs.jmedchem.1c01782
Escherichia coli Escherichia coli MIC 1.56 ug.mL-1 10.1016/j.ejmech.2019.05.075
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.2c01469
Escherichia coli Escherichia coli MIC 3.1 ug.mL-1 10.1021/acs.jmedchem.1c01782
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/acsmedchemlett.0c00653
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2020.127163
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2020.112141
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/acs.jnatprod.2c00621
Escherichia coli Escherichia coli MIC 90.0 nM 10.1016/j.ejmech.2021.113447
Escherichia coli Escherichia coli MIC 250.0 nM 10.1021/acsmedchemlett.1c00683
Escherichia coli Escherichia coli MIC 380.0 nM 10.1021/acs.jmedchem.6b00922
Escherichia coli Escherichia coli MIC 500.0 nM 10.1016/j.ejmech.2021.113433
Escherichia coli Escherichia coli MIC 1540.0 nM 10.1021/acs.jmedchem.6b00922
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1016/j.ejmech.2019.111636
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 3070.0 nM 10.1021/acs.jmedchem.6b00922
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1016/j.ejmech.2019.111636
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.2c01076
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acsmedchemlett.1c00683
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1016/j.ejmech.2019.111636
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 16000.0 nM 10.1016/j.ejmech.2019.111636
Escherichia coli Escherichia coli MIC>95 0.5 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MIC>95 1.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MIC>95 2.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MIC95 1.0 uM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC95 2.0 uM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli Ratio 2.0 None 10.1016/j.ejmech.2019.111636
Fungi Fungi MIC 12340.0 nM 10.1021/acs.jmedchem.1c00614
Homo sapiens HK-2 Activity nan None 10.1021/acs.jmedchem.2c01076
Homo sapiens HK-2 CC50 128000.0 nM 10.1021/acs.jmedchem.1c02140
Homo sapiens HK-2 Ratio IC50 1.0 None 10.1016/j.bmcl.2020.127163
Homo sapiens LSD1/CoREST complex Kd 463.0 nM 10.1039/d0md00141d
Homo sapiens NHDF LD50 512.0 uM 10.1021/acsmedchemlett.1c00683
Homo sapiens RPTEC TC50 27.0 uM 10.1021/jm400416u
Homo sapiens U-937 Inhibition 28.0 % 10.1016/j.ejmech.2018.03.025
Homo sapiens U-937 Inhibition 44.0 % 10.1016/j.ejmech.2018.03.025
Klebsiella aerogenes Klebsiella aerogenes Activity 14.0 % 10.1021/acs.jmedchem.0c01335
Klebsiella pneumoniae Klebsiella pneumoniae Activity 3.21 10^4CFU/ml 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1021/acs.jnatprod.6b00807
Klebsiella pneumoniae Klebsiella pneumoniae FIC 0.3125 None 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae FIC 0.5 None 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae FIC nan None 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae MBC 2.0 ug ml-1 10.1021/acs.jmedchem.2c01469
Klebsiella pneumoniae Klebsiella pneumoniae MBC>99.9 8.0 uM 10.1021/acs.jmedchem.8b01348
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2020.127163
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.7b01367
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.8b00790
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1021/acs.jnatprod.6b00807
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1021/jm400416u
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c00818
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c01469
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.8b00790
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.5 ug.mL-1 10.1021/acs.jmedchem.1c01782
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.7b01367
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2020.127163
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.2 ug.mL-1 10.1021/acs.jmedchem.1c01782
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4000.0 nM 10.1021/acs.jmedchem.1c02140
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4000.0 nM 10.1021/acs.jmedchem.2c01076
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8000.0 nM 10.1016/j.ejmech.2019.111636
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16000.0 nM 10.1021/acsmedchemlett.1c00683
Klebsiella pneumoniae Klebsiella pneumoniae MIC>95 4.0 uM 10.1021/acs.jmedchem.8b01348
Listeria monocytogenes Listeria monocytogenes MIC 12290.0 nM 10.1021/acs.jmedchem.6b00922
Listeria monocytogenes Listeria monocytogenes MIC 24590.0 nM 10.1021/acs.jmedchem.6b00922
Micrococcus luteus Micrococcus luteus MIC 98340.0 nM 10.1021/acs.jmedchem.6b00922
Mus musculus 3LL cell line IC50 nan None 10.1021/acs.jmedchem.2c01293
Mus musculus J774.1 IC50 8500.0 nM 10.1021/acs.jnatprod.7b00324
Mus musculus RAW264.7 Activity 23.97 % 10.1016/j.ejmech.2020.112580
Mus musculus RAW264.7 Activity 43.62 % 10.1016/j.ejmech.2020.112580
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 6.38 log10CFU/ml 10.1016/j.ejmech.2022.114318
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1016/j.ejmech.2022.114318
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 1.0 None 10.1021/acs.jmedchem.1c00888
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 2.0 None 10.1021/acs.jmedchem.1c00888
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 32.0 None 10.1016/j.ejmech.2022.114318
Pseudomonas aeruginosa Pseudomonas aeruginosa FIC 0.3125 None 10.1021/acs.jmedchem.1c00614
Pseudomonas aeruginosa Pseudomonas aeruginosa FIC nan None 10.1021/acs.jmedchem.1c00614
Pseudomonas aeruginosa Pseudomonas aeruginosa log(activity) -2.55 None 10.1021/acs.jnatprod.6b00807
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 2.0 ug ml-1 10.1021/acs.jmedchem.2c01469
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 16.0 mg/L 10.1021/jm400416u
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC>99.9 2.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC>99.9 4.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC>99.9 8.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC>99.9 32.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1016/j.bmcl.2020.127163
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1021/acs.jnatprod.6b00807
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1021/jm400416u
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.7 ug.mL-1 10.1021/acs.jmedchem.1c01782
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c00818
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.2c01469
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.2c01469
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.7b01367
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.1c00888
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/jm400416u
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.bmcl.2020.127163
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.1c00888
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 150.0 nM 10.1016/j.ejmech.2021.113447
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1016/j.ejmech.2022.114318
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1000.0 nM 10.1016/j.ejmech.2021.113433
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2000.0 nM 10.1016/j.ejmech.2019.111636
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2000.0 nM 10.1021/acs.jmedchem.1c00614
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2000.0 nM 10.1021/acs.jmedchem.1c02140
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2000.0 nM 10.1021/acs.jmedchem.2c01076
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8192.0 ug.mL-1 10.1016/j.ejmech.2022.114318
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC100 2.0 ug ml-1 10.1021/acs.jmedchem.0c02217
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC>95 2.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC>95 4.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC>95 16.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas fluorescens Pseudomonas fluorescens MIC 49170.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica Salmonella enterica MIC 1540.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC 1540.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC 770.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC 3070.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Paratyphi B Salmonella enterica subsp. enterica serovar Paratyphi B MIC 1540.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC>99.9 4.0 uM 10.1021/acs.jmedchem.8b01348
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 770.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC>95 2.0 uM 10.1021/acs.jmedchem.8b01348
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC95 2.0 uM 10.1021/acs.jmedchem.7b01729
Shigella flexneri Shigella flexneri MIC 770.0 nM 10.1021/acs.jmedchem.6b00922
Staphylococcus aureus Staphylococcus aureus Activity 0.0 CFU/g 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2020.113138
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.1c00614
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.1c01782
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.1c01905
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.2c01469
Staphylococcus aureus Staphylococcus aureus FC 2.0 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FC 4.0 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FC nan None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 0.375 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 0.5 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 0.5625 None 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus FICI 0.5625 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 0.625 None 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus FICI 0.625 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 0.75 None 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus FICI 0.75 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 1.0 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 1.062 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus FICI 2.0 None 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus Inhibition nan % 10.1016/j.ejmech.2019.111636
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1021/acs.jmedchem.2c01469
Staphylococcus aureus Staphylococcus aureus MBC99.9 64.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MIC 0.7 ug.mL-1 10.1021/acs.jmedchem.1c01782
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1021/acs.jnatprod.1c00222
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.2c01469
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/acs.jnatprod.1c00222
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1016/j.ejmech.2020.112141
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1016/j.ejmech.2020.113138
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1016/j.ejmech.2021.113433
Staphylococcus aureus Staphylococcus aureus MIC 16000.0 nM 10.1016/j.ejmech.2019.111636
Staphylococcus aureus Staphylococcus aureus MIC 16000.0 nM 10.1016/j.ejmech.2020.113138
Staphylococcus aureus Staphylococcus aureus MIC 16000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus aureus Staphylococcus aureus MIC 16000.0 nM 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus MIC 16000.0 nM 10.1021/acs.jmedchem.2c01076
Staphylococcus aureus Staphylococcus aureus MIC 32000.0 nM 10.1016/j.ejmech.2019.111636
Staphylococcus aureus Staphylococcus aureus MIC 32000.0 nM 10.1021/acsmedchemlett.1c00683
Staphylococcus aureus Staphylococcus aureus MIC 49170.0 nM 10.1021/acs.jmedchem.6b00922
Staphylococcus aureus Staphylococcus aureus MIC 64000.0 nM 10.1016/j.ejmech.2019.111636
Staphylococcus aureus Staphylococcus aureus MIC 64000.0 nM 10.1021/acsmedchemlett.1c00683
Staphylococcus aureus Staphylococcus aureus MIC 98340.0 nM 10.1021/acs.jmedchem.6b00922
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/acs.jmedchem.2c00818
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/acs.jmedchem.2c01469
Staphylococcus aureus Staphylococcus aureus MIC95 32.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MIC95 64.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MIC99 32.0 ug ml-1 10.1021/acs.jmedchem.2c01293
Staphylococcus aureus Staphylococcus aureus MIC99 128.0 ug ml-1 10.1021/acs.jmedchem.2c01293
Staphylococcus aureus Staphylococcus aureus Ratio 2.0 None 10.1016/j.ejmech.2019.111636
Staphylococcus aureus Staphylococcus aureus TIME 6.0 hr 10.1021/acs.jmedchem.1c02140
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1016/j.ejmech.2020.113138
Staphylococcus epidermidis Staphylococcus epidermidis MBC99.9 32.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus epidermidis Staphylococcus epidermidis MIC 2000.0 nM 10.1016/j.ejmech.2021.113433
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8000.0 nM 10.1016/j.ejmech.2020.113138
Staphylococcus epidermidis Staphylococcus epidermidis MIC 16000.0 nM 10.1021/acs.jmedchem.1c02140
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus epidermidis Staphylococcus epidermidis MIC95 32.0 uM 10.1021/acs.jmedchem.7b01729
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1021/acs.jmedchem.1c01782
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8000.0 nM 10.1021/acsmedchemlett.1c00683
Streptococcus pneumoniae Streptococcus pneumoniae MIC nan None 10.1021/acs.jmedchem.2c01469
Streptococcus pyogenes Streptococcus pyogenes MIC 32000.0 nM 10.1021/acsmedchemlett.1c00683
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC 770.0 nM 10.1021/acs.jmedchem.6b00922
None ADMET Activity nan None 10.1016/j.ejmech.2020.113138
None ADMET Activity nan None 10.1021/acs.jmedchem.1c00614
None ADMET Activity nan None 10.1021/acs.jmedchem.1c02140
None ADMET Activity nan None 10.1021/acs.jmedchem.2c01076
None ADMET LD50 16.4 mg.kg-1 10.1021/acs.jmedchem.1c00614
None ADMET LD50 25.48 mg.kg-1 10.1021/acs.jmedchem.1c02140
None ADMET Ratio 19.03 None 10.1021/acs.jmedchem.1c00614
None ADMET Ratio 90.51 None 10.1021/acs.jmedchem.1c00614
None ADMET Ratio 4150.0 None 10.1021/acs.jmedchem.1c00614
None ADMET Stability nan % 10.1021/acs.jmedchem.2c01076
None ADMET T1/2 12.54 hr 10.1021/acs.jmedchem.2c01076
None ADMET TI 164.62 None 10.1021/acs.jmedchem.6b00922
None ADMET TI nan None 10.1016/j.ejmech.2020.113138
None ADMET TI nan None 10.1021/acs.jmedchem.6b00922
None Erythrocyte Activity nan None 10.1021/acs.jmedchem.1c01782
None Erythrocyte Activity nan None 10.1021/acs.jmedchem.2c01293
None Erythrocyte HC10 256.0 uM 10.1021/acs.jmedchem.1c02140
None Erythrocyte HC5 nan None 10.1021/acs.jmedchem.2c00818
None Erythrocyte MHC10 98.34 uM 10.1021/acs.jmedchem.6b00922
None Erythrocyte MHC10 256.0 uM 10.1021/acs.jmedchem.2c01076
None Erythrocyte MHC10 512.0 uM 10.1021/acs.jmedchem.1c00614
None Erythrocyte MHC10 nan None 10.1016/j.ejmech.2020.113138
None No relevant target Retention_time 13.12 min 10.1021/acs.jmedchem.2c01076
None Unchecked Activity nan None 10.1016/j.ejmech.2019.05.075
None Unchecked Activity nan None 10.1016/j.ejmech.2020.113138
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c00614
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c02140
None Unchecked CC50 nan None 10.1021/acs.jmedchem.2c01076
None Unchecked HC50 nan None 10.1021/acs.jmedchem.2c01469
None Unchecked IC50 170000.0 nM 10.1016/j.ejmech.2018.05.001
None Unchecked IC50 512000.0 nM 10.1021/acs.jmedchem.1c00614
None Unchecked Inhibition 63.9 % 10.1016/j.ejmech.2018.05.001
None Unchecked MBC>99.9 1.0 uM 10.1021/acs.jmedchem.8b01348
None Unchecked MBC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
None Unchecked MIC>95 0.5 uM 10.1021/acs.jmedchem.8b01348
None Unchecked MIC95 1.0 uM 10.1021/acs.jmedchem.7b01729

Metabolism Information