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name Structure Reference Source Properties Activities Metabolism

(Z,3E)-6'-bromo-3-(hydroxyimino)-1',2'-dihydro-1H,3H-[2,3'-biindolyliden]-2'-one

AlkaPlorer ID: AK323436

Synonym: None

IUPAC Name: 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol

Structure

SMILES: O=C1NC2=CC(Br)=CC=C2/C1=C1/NC2=CC=CC=C2/C1=N\O

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InChI: InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+

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InChIKey: DDLZLOKCJHBUHD-WAVHTBQISA-N

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Reference

CAS: 667463-62-9

NPASS: NPC482688

Source

Species Genus Family Order Class Phylum Kingdom Domain
Glycosmis chlorosperma Glycosmis Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 356.17900000000003

TPSA？: 73.72

MolLogP？: 3.4163000000000023

Number of H-Donors: 3

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1039/d2md00370h
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1039/d2md00370h
Chlorocebus sabaeus Vero C1008 CC50 33000.0 nM 10.6019/CHEMBL4495565
Danio rerio Danio rerio Activity nan None 10.1038/nchembio.147
Danio rerio Glycogen synthase kinase 3 beta Inhibition nan % 10.1038/nchembio.147
Escherichia coli Escherichia coli Activity nan None 10.1039/d2md00370h
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1039/d2md00370h
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change -0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens A2058 Activity 80.0 % 10.1016/j.ejmech.2021.113652
Homo sapiens Activin receptor type-1B Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change 2.4 degrees C 10.1073/pnas.0708800104
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Arachidonate 15-lipoxygenase Inhibition nan % 10.1021/jm401740w
Homo sapiens Arachidonate 5-lipoxygenase Activity nan None 10.1021/jm401740w
Homo sapiens Arachidonate 5-lipoxygenase IC50 500.0 nM 10.1021/jm401740w
Homo sapiens Arachidonate 5-lipoxygenase IC50 1500.0 nM 10.1021/jm401740w
Homo sapiens Arachidonate 5-lipoxygenase Inhibition 32.4 % 10.1021/jm401740w
Homo sapiens Arachidonate 5-lipoxygenase Inhibition 38.0 % 10.1021/jm401740w
Homo sapiens Arachidonate 5-lipoxygenase Inhibition nan % 10.1021/jm401740w
Homo sapiens Bile acid receptor FXR IC50 3400.0 nM 10.1016/j.bmc.2013.04.069
Homo sapiens Bile acid receptor FXR Inhibition 96.3 % 10.1016/j.bmc.2013.04.069
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Thermal melting change -0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Thermal melting change -0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Thermal melting change 4.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase beta Thermal melting change 6.3 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I delta Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Thermal melting change 3.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase II Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change -1.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CDK2/Cyclin A2 IC50 69.0 nM 10.1021/acs.jmedchem.8b00049
Homo sapiens CDK2/Cyclin A2 Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens CDK3/cyclin E Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens CDK7/Cyclin H/MNAT1 IC50 3500.0 nM 10.1021/acs.jmedchem.8b00049
Homo sapiens CDK9/cyclin T1 IC50 450.0 nM 10.1021/acs.jmedchem.8b00049
Homo sapiens CDK9/cyclin T1 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1 IC50 320.0 nM 10.1021/np400856h
Homo sapiens Cyclin-dependent kinase 1 IC50 320.0 nM 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 320.0 nM 10.1016/j.tips.2004.07.006
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 320.0 nM 10.1021/jm031016d
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Activity 21.0 % 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Activity 85.0 % 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 270.0 nM 10.1021/acs.jmedchem.8b00049
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 320.0 nM 10.1021/jm800648y
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change 4.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 8.0 % 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 55.0 % 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 2/cyclin A Inhibition 70.0 % 10.1016/j.bmc.2009.09.008
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 14.0 nM 10.1021/acs.jmedchem.8b00049
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 527.0 nM 10.1021/acs.jmedchem.8b00049
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Cyclin-dependent kinase 5 IC50 83.0 nM 10.1021/ml300207a
Homo sapiens Cyclin-dependent kinase 5 IC50 83.0 nM 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 5 IC50 85.0 nM 10.1021/np400856h
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Activity 6.0 % 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Activity 29.0 % 10.1021/np9003905
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 41.0 nM 10.1021/acs.jmedchem.8b00049
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 83.0 nM 10.1016/j.bmc.2014.01.044
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 83.0 nM 10.1016/j.ejmech.2021.113652
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 83.0 nM 10.1021/jm031016d
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 83.0 nM 10.1021/jm060314i
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change 1.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclooxygenase-2 Inhibition nan % 10.1021/jm401740w
Homo sapiens Death-associated protein kinase 1 Residual Activity 46.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Thermal melting change 3.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change 3.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 1.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change -0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 52.0 nM 10.1021/np400856h
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 2100.0 nM 10.1021/ml300207a
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Dual specificty protein kinase CLK1 IC50 2100.0 nM 10.1016/j.bmc.2014.01.044
Homo sapiens Dual specificty protein kinase CLK1 IC50 2100.0 nM 10.1021/np400856h
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Ephrin type-A receptor 1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Epoxide hydratase Inhibition nan % 10.1021/jm401740w
Homo sapiens Fibroblast growth factor receptor 1 Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 IC50 5.0 nM 10.1021/jm031016d
Homo sapiens Glycogen synthase kinase-3 IC50 5.0 nM 10.1021/jm060314i
Homo sapiens Glycogen synthase kinase-3 IC50 5.0 nM 10.1021/np400856h
Homo sapiens Glycogen synthase kinase-3 IC50 290.0 nM 10.1021/jm800648y
Homo sapiens Glycogen synthase kinase-3 Inhibition nan % 10.1021/jm401740w
Homo sapiens Glycogen synthase kinase-3 alpha IC50 5.0 nM 10.1073/pnas.0708800104
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Activity 7.0 % 10.1021/np9003905
Homo sapiens Glycogen synthase kinase-3 beta Activity 66.0 % 10.1021/np9003905
Homo sapiens Glycogen synthase kinase-3 beta Activity nan None 10.1021/np9003905
Homo sapiens Glycogen synthase kinase-3 beta IC50 1500.0 nM 10.1016/j.ejmech.2016.09.058
Homo sapiens Glycogen synthase kinase-3 beta Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 9.9 degrees C 10.1073/pnas.0708800104
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens HCT-116 Activity 30.0 % 10.1021/acs.jmedchem.8b00049
Homo sapiens HCT-116 IC50 5200.0 nM 10.1016/j.bmc.2009.09.008
Homo sapiens Hepatocyte growth factor receptor Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens HepG2 IC50 5300.0 nM 10.1016/j.bmc.2017.07.009
Homo sapiens HepG2 IC50 relative 26500.0 nM 10.6019/EOS300108
Homo sapiens Histone deacetylase 6 IC50 698.0 nM 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 2.55 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 89.81 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 93.39 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 IC50 5400.0 nM 10.1016/j.bmc.2009.09.008
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Huh-7 IC50 6200.0 nM 10.1016/j.bmc.2009.09.008
Homo sapiens IMR-32 Activity nan None 10.1016/j.bmcl.2011.07.011
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 1.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 127.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase IC50 600.0 nM 10.1016/j.bmcl.2011.04.149
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens K562 IC50 1300.0 nM 10.1016/j.bmc.2009.09.008
Homo sapiens KCL-22 Activity 50.0 % 10.1021/acs.jnatprod.6b00285
Homo sapiens LIM domain kinase 1 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Thermal melting change -2.5 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase p38 delta Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens MCF7 Activity 75.0 % 10.1016/j.ejmech.2021.113652
Homo sapiens Misshapen-like kinase 1 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change -1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens PDZ-binding kinase Thermal melting change 1.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Pregnane X receptor EC50 nan None 10.1016/j.bmc.2013.04.069
Homo sapiens Pregnane X receptor max activation 42.6 % 10.1016/j.bmc.2013.04.069
Homo sapiens Prostaglandin E synthase Inhibition nan % 10.1021/jm401740w
Homo sapiens Protein kinase C alpha Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Pyruvate dehydrogenase kinase isoform 1 IC50 1500.0 nM 10.1016/j.ejmech.2021.113652
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 4.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 7.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 7.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change 1.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change 4.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change nan None 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 2.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A IC50 600.0 nM 10.1021/jm070077z
Homo sapiens Serine/threonine-protein kinase Aurora-A Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B IC50 900.0 nM 10.1021/jm070077z
Homo sapiens Serine/threonine-protein kinase Aurora-B Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C IC50 200.0 nM 10.1021/jm070077z
Homo sapiens Serine/threonine-protein kinase Aurora-C Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Inhibition nan % 10.1021/acs.jmedchem.7b00324
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change 2.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 141.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change 4.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 3.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 4.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 1.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change 3.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change 4.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change -1.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 1.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change 4.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens SH-SY5Y Activity 80.0 % 10.1021/jm060314i
Homo sapiens SH-SY5Y EC50 30000.0 nM 10.1021/jm401740w
Homo sapiens SH-SY5Y IC50 9000.0 nM 10.1021/jm800648y
Homo sapiens SH-SY5Y IC50 9500.0 nM 10.1021/jm060314i
Homo sapiens SH-SY5Y IC50 10000.0 nM 10.1021/jm060314i
Homo sapiens SH-SY5Y IC50 13000.0 nM 10.1021/jm060314i
Homo sapiens SH-SY5Y IC50 18000.0 nM 10.1021/jm060314i
Homo sapiens SH-SY5Y Survival 5.0 % 10.1021/jm060314i
Homo sapiens SK-N-SH Activity nan None 10.1016/j.bmcl.2011.07.011
Homo sapiens Stem cell growth factor receptor Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change 1.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity -4.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change 7.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 1.0 % 10.1042/bj20121418
Klebsiella pneumoniae Klebsiella pneumoniae FC 16.0 None 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae FC 512.0 None 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1039/d2md00370h
Klebsiella pneumoniae Klebsiella pneumoniae MIC 200000.0 nM 10.1039/d2md00370h
Mus musculus HT-22 Activity nan None 10.1016/j.bmcl.2017.10.069
Mus musculus Spiral organ of cochlea EC50 570.0 nM 10.1021/acs.jmedchem.8b00669
Ovis aries Cyclooxygenase-1 Inhibition nan % 10.1021/jm401740w
Plasmodium falciparum Plasmodium falciparum IC50 1584.89 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1995.26 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 3162.28 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 3981.07 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1039/d2md00370h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1039/d2md00370h
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A IC50 520.0 nM 10.1016/j.bmc.2014.01.044
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A IC50 1700.0 nM 10.1021/ml300207a
Schistosoma mansoni Schistosoma mansoni EC50 2340.0 nM 10.6019/CHEMBL5096127
Schistosoma mansoni Schistosoma mansoni In vitro activity nan None 10.6019/CHEMBL5096127
Schistosoma mansoni Schistosoma mansoni Worm movement inhibition 95.74 % 10.6019/CHEMBL5096127
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 9.52 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 14.47 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 33000.0 nM 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 relative nan None 10.6019/EOS300033
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -2.77 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 9.37 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 21.31 % 10.6019/CHEMBL4495565
Sus scrofa Casein kinase I isoform alpha IC50 1200.0 nM 10.1021/ml300207a
Sus scrofa Glycogen synthase kinase-3 IC50 5.0 nM 10.1016/j.bmc.2014.01.044
Sus scrofa Glycogen synthase kinase-3 IC50 5.0 nM 10.1016/j.ejmech.2021.113652
Sus scrofa Glycogen synthase kinase 3 beta IC50 5.0 nM 10.1021/ml300207a
Toxoplasma gondii Toxoplasma gondii ID50 0.51 uM 10.1128/aac.00903-08
None ADMET Activity nan None 10.1021/jm401740w
None ADMET IC50 1900.0 nM 10.1016/j.bmc.2009.09.008
None ADMET Selectivity index 1.0 None 10.6019/CHEMBL4495565
None ADMET TD50 16.0 uM 10.1128/aac.00903-08
None ADMET TI 31.0 None 10.1128/aac.00903-08
None Molecular identity unknown Activity nan None 10.1016/j.bmcl.2009.02.083
None Molecular identity unknown FC 2.7 None 10.1016/j.bmcl.2009.02.083
None Molecular identity unknown Fold change 0.81 None 10.1021/jm701582f
None Molecular identity unknown Fold change 1.02 None 10.1021/jm701582f
None Molecular identity unknown Fold change 1.04 None 10.1021/jm701582f
None Molecular identity unknown Fold change 1.2 None 10.1021/jm701582f
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2011.07.011
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/jm401740w
None NON-PROTEIN TARGET IC50 500.0 nM 10.1021/jm401740w
None NON-PROTEIN TARGET IC50 1600.0 nM 10.1021/jm401740w
None NON-PROTEIN TARGET IC50 3000.0 nM 10.1021/jm401740w
None No relevant target LogD 2.59 None 10.1021/jm800648y
None No relevant target Solubility 5.0 ug.mL-1 10.1021/jm800648y
None Radical scavenging activity Activity nan None 10.1021/jm401740w
None Unchecked Activity 80.0 % 10.1016/j.ejmech.2021.113652
None Unchecked EC50 192.0 nM 10.1021/acs.jmedchem.8b00669
None Unchecked FC 0.758 None 10.1016/j.bmc.2019.05.025
None Unchecked FC 1.388 None 10.1016/j.bmc.2019.05.025
None Unchecked IC50 5.0 nM 10.1021/jm401740w
None Unchecked IC50 5.0 nM 10.1021/jm800648y
None Unchecked IC50 5.0 nM 10.1021/np9003905
None Unchecked IC50 10.0 nM 10.1016/j.tips.2004.07.006
None Unchecked IC50 83.0 nM 10.1021/jm800648y
None Unchecked IC50 83.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 300.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 320.0 nM 10.1016/j.ejmech.2021.113652
None Unchecked IC50 320.0 nM 10.1021/jm060314i
None Unchecked IC50 320.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 1900.0 nM 10.1016/j.bmc.2014.01.044
None Unchecked IC50 1900.0 nM 10.1021/np400856h
None Unchecked IC50 10000.0 nM 10.1073/pnas.0708800104

Metabolism Information