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name Structure Reference Source Properties Activities Metabolism

4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol

AlkaPlorer ID: AK323500

Synonym: None

IUPAC Name: 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol

Structure

SMILES: CC(C)NCC(O)C1=CC=C(O)C(O)=C1

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InChI: InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3

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InChIKey: JWZZKOKVBUJMES-UHFFFAOYSA-N

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Reference

PubChem CID: 3779

CAS: 149-53-1

NPASS: NPC483291

COCONUT: CNP0339677.2

Properties Information

Molecule Weight: 211.261

TPSA？: 72.72

MolLogP？: 1.1291999999999998

Number of H-Donors: 4

Number of H-Acceptors: 4

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 79432.8 nM None
Bos taurus Beta-2 adrenergic receptor Kd 330.0 nM 10.1021/jm00147a037
Bos taurus Beta-2 adrenergic receptor Ki 110.0 nM 10.1021/jm00073a006
Bos taurus Beta-2 adrenergic receptor Ki 110.0 nM 10.1021/jm00084a006
Bos taurus Beta-2 adrenergic receptor -Log KD 6.51 None 10.1021/jm00147a037
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Callithrix jacchus Adrenoceptor beta 3 Activity nan None 10.1021/acs.jmedchem.6b01197
Canis lupus familiaris Beta-2 adrenergic receptor IC50 0.1 nM 10.1021/jm000455z
Canis lupus familiaris Beta-2 adrenergic receptor IC50 0.1 nM 10.1021/jm020177z
Canis lupus familiaris Beta-2 adrenergic receptor IC50 1000.0 nM 10.1021/jm00094a025
Canis lupus familiaris Canis familiaris Activity 20.0 % 10.1021/jm00228a020
Canis lupus familiaris Canis familiaris Activity 40.0 % 10.1021/jm00228a020
Canis lupus familiaris Canis familiaris Activity 60.0 % 10.1021/jm00228a020
Canis lupus familiaris Canis familiaris BP -27.0 mmHg 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris BP -17.0 mmHg 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris Change -27.0 % 10.1021/jm00354a017
Canis lupus familiaris Canis familiaris Change -6.6 % 10.1021/jm00148a006
Canis lupus familiaris Canis familiaris Change -1.0 % 10.1021/jm00354a017
Canis lupus familiaris Canis familiaris Change 0.4 % 10.1021/jm00148a006
Canis lupus familiaris Canis familiaris Change 1.0 % 10.1021/jm00148a006
Canis lupus familiaris Canis familiaris Change 10.4 % 10.1021/jm00148a006
Canis lupus familiaris Canis familiaris Change 19.0 % 10.1021/jm00354a017
Canis lupus familiaris Canis familiaris Change 31.0 % 10.1021/jm00148a006
Canis lupus familiaris Canis familiaris Change 96.0 % 10.1021/jm00148a006
Canis lupus familiaris Canis familiaris Change 133.0 % 10.1021/jm00354a017
Canis lupus familiaris Canis familiaris ED25 0.019 ug/kg 10.1021/jm00218a024
Canis lupus familiaris Canis familiaris ED25 1.0 ug kg-1 10.1021/jm00137a030
Canis lupus familiaris Canis familiaris ED50 6.9e-05 mg.kg-1 10.1021/jm00218a024
Canis lupus familiaris Canis familiaris ED50 0.0008 umol.kg-1 10.1021/jm00135a015
Canis lupus familiaris Canis familiaris ED50 0.001 mg.kg-1 10.1021/jm00137a030
Canis lupus familiaris Canis familiaris ED50 0.0014 umol.kg-1 10.1021/jm00135a015
Canis lupus familiaris Canis familiaris HR 13.0 beats min-1 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris HR 35.0 beats min-1 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris Inhibition 20.0 % 10.1021/jm00228a020
Canis lupus familiaris Canis familiaris Inhibition 70.0 % 10.1021/jm00228a020
Canis lupus familiaris Canis familiaris ISA 100.0 % 10.1021/jm00135a015
Canis lupus familiaris Canis familiaris Potency 0.11 nM kg-1 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris Potency 0.35 nM kg-1 10.1021/jm00139a013
Canis lupus familiaris Canis familiaris Ratio nan None 10.1021/jm701324c
Canis lupus familiaris Canis familiaris Ratio nan None 10.1021/jm8000345
Canis lupus familiaris Canis familiaris Ratio nan None 10.1021/jm800222k
Canis lupus familiaris Canis familiaris Ratio AUC nan None 10.1021/jm800222k
Canis lupus familiaris Canis familiaris Selectivity 0.5 None 10.1021/jm00135a015
Canis lupus familiaris Canis familiaris TIME 0.25 hr 10.1021/jm00228a020
Canis lupus familiaris Canis familiaris TIME 1.0 hr 10.1021/jm00228a020
Canis lupus familiaris Canis familiaris TIME 2.0 hr 10.1021/jm00228a020
Cavia porcellus Beta-1 adrenergic receptor Activity nan None 10.1021/jm00199a013
Cavia porcellus Beta-1 adrenergic receptor Activity nan None 10.1021/jm801016j
Cavia porcellus Beta-1 adrenergic receptor EC50 6.0 nM 10.1021/jm00107a027
Cavia porcellus Beta-1 adrenergic receptor ED25 3.4 nM 10.1021/jm00220a007
Cavia porcellus Beta-1 adrenergic receptor ED50 1.3 uM 10.1021/jm00199a013
Cavia porcellus Beta-1 adrenergic receptor ED50 2.1 10'-8M 10.1021/jm00220a007
Cavia porcellus Beta-1 adrenergic receptor ED50 2.2 uM 10.1021/jm00199a013
Cavia porcellus Beta-1 adrenergic receptor IA 1.0 None 10.1021/jm00073a006
Cavia porcellus Beta-1 adrenergic receptor Intrinsic activity 1.0 None 10.1021/jm00084a006
Cavia porcellus Beta-1 adrenergic receptor pD2 7.66 None 10.1021/jm00199a013
Cavia porcellus Beta-1 adrenergic receptor pD2 7.87 None 10.1021/jm00199a013
Cavia porcellus Beta-1 adrenergic receptor pD2 8.45 None 10.1021/jm00073a006
Cavia porcellus Beta-1 adrenergic receptor pD2 8.45 None 10.1021/jm00084a006
Cavia porcellus Beta-2 adrenergic receptor Activity nan None 10.1016/j.bmcl.2012.01.013
Cavia porcellus Beta-2 adrenergic receptor Activity nan None 10.1016/j.bmcl.2012.11.058
Cavia porcellus Beta-2 adrenergic receptor Activity nan None 10.1016/j.bmcl.2013.11.028
Cavia porcellus Beta-2 adrenergic receptor EC50 7.9 nM 10.1021/acs.jnatprod.9b00418
Cavia porcellus Beta-2 adrenergic receptor EC50 28.84 nM 10.1016/j.bmcl.2012.11.058
Cavia porcellus Beta-2 adrenergic receptor EC50 31.62 nM 10.1016/j.bmcl.2012.01.013
Cavia porcellus Beta-2 adrenergic receptor EC50 31.62 nM 10.1016/j.bmcl.2013.11.028
Cavia porcellus Beta-2 adrenergic receptor EC50 31.64 nM 10.1016/j.bmcl.2013.11.028
Cavia porcellus Beta-2 adrenergic receptor EC50 58.0 nM 10.1021/jm00107a027
Cavia porcellus Beta-2 adrenergic receptor ED50 2.1 10'-8M 10.1021/jm00199a013
Cavia porcellus Beta-2 adrenergic receptor ED50 7.1 nM 10.1021/jm00220a007
Cavia porcellus Beta-2 adrenergic receptor ED50 7.8 10'-8M 10.1021/jm00199a013
Cavia porcellus Beta-2 adrenergic receptor Emax 100.0 % 10.1016/j.bmcl.2012.11.058
Cavia porcellus Beta-2 adrenergic receptor Emax 197.52 % 10.1016/j.bmc.2018.10.043
Cavia porcellus Beta-2 adrenergic receptor IA 1.0 None 10.1021/jm00073a006
Cavia porcellus Beta-2 adrenergic receptor Intrinsic activity 1.0 None 10.1021/jm00084a006
Cavia porcellus Beta-2 adrenergic receptor Intrinsic activity 1.0 None 10.1021/jm00220a007
Cavia porcellus Beta-2 adrenergic receptor Kd 17.78 nM 10.1016/j.bmcl.2014.12.077
Cavia porcellus Beta-2 adrenergic receptor Kd 25.12 nM 10.1016/j.bmcl.2014.12.077
Cavia porcellus Beta-2 adrenergic receptor pD2 7.1 None 10.1021/jm00199a013
Cavia porcellus Beta-2 adrenergic receptor pD2 7.44 None 10.1016/j.bmc.2018.10.043
Cavia porcellus Beta-2 adrenergic receptor pD2 8.33 None 10.1021/jm00073a006
Cavia porcellus Beta-2 adrenergic receptor pD2 8.33 None 10.1021/jm00084a006
Cavia porcellus Beta-2 adrenergic receptor TIME 0.03667 hr 10.1016/j.bmc.2018.10.043
Cavia porcellus Cavia porcellus EC50 3.2 nM 10.1021/jm00139a013
Cavia porcellus Cavia porcellus EC50 6.2 nM 10.1021/jm00139a013
Cavia porcellus Cavia porcellus ED50 1.5 M 10.1021/jm00162a002
Cavia porcellus Cavia porcellus ED50 1.5 M 10.1021/jm00162a003
Cavia porcellus Cavia porcellus IC50 150.0 nM 10.1021/jm00378a017
Cavia porcellus Cavia porcellus Intrinsic activity 1.0 None 10.1021/jm00162a002
Cavia porcellus Cavia porcellus Intrinsic activity 1.0 None 10.1021/jm00162a003
Cavia porcellus Cavia porcellus RIA 1.0 None 10.1021/jm00139a013
Cavia porcellus Cavia porcellus TIME 0.05167 hr 10.1016/j.ejmech.2021.113697
Cavia porcellus Cavia porcellus TIME 0.1137 hr 10.1021/jm00189a012
Cavia porcellus Cavia porcellus TIME 0.1337 hr 10.1021/jm00189a012
Cavia porcellus Cavia porcellus TIME 0.2118 hr 10.1021/jm00189a012
Cavia porcellus Cavia porcellus TIME 0.2945 hr 10.1021/jm00189a012
Cavia porcellus Heart Activity nan None 10.1021/np50065a024
Cavia porcellus Heart MEC 4.7 10'-7M 10.1021/np50065a024
Cavia porcellus Heart MEC 4.7 10'-8M 10.1021/np50065a024
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cavia porcellus Smooth muscle of trachea Emax 254.48 % 10.1016/j.ejmech.2018.04.041
Cavia porcellus Smooth muscle of trachea pD2 8.16 None 10.1016/j.ejmech.2018.04.041
Cavia porcellus Trachea Activity 100.0 % 10.1021/acs.jmedchem.1c02006
Danio rerio Danio rerio Activity nan None 10.1038/nchembio.307
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 20290.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adrenergic receptor alpha-1 EC50 1.5 nM 10.1021/jm00094a025
Homo sapiens Adrenergic receptor alpha-2 IA 0.74 None 10.1021/jm00073a006
Homo sapiens Adrenergic receptor alpha-2 Intrinsic activity 0.74 None 10.1021/jm00084a006
Homo sapiens Adrenergic receptor alpha-2 pD2 4.95 None 10.1021/jm00073a006
Homo sapiens Adrenergic receptor alpha-2 pD2 4.95 None 10.1021/jm00084a006
Homo sapiens Adrenergic receptor beta EC50 30.0 nM 10.1021/jm00348a014
Homo sapiens Adrenergic receptor beta Intrinsic activity 1.0 None 10.1021/jm00155a025
Homo sapiens Adrenergic receptor beta pD2 8.35 None 10.1021/jm00155a025
Homo sapiens Adrenergic receptor beta pD2 8.47 None 10.1021/jm00155a025
Homo sapiens Adrenergic receptor beta; ADRB1 & ADRB3 Ratio EC50 0.3 None 10.1021/jm0509445
Homo sapiens Adrenergic receptor beta; ADRB1 & ADRB3 Selectivity 0.087 None 10.1016/j.bmcl.2004.11.001
Homo sapiens Alpha-1a adrenergic receptor AC50 2116.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 9424.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor EC50 nan None 10.1021/acs.jmedchem.5b00638
Homo sapiens Alpha-1a adrenergic receptor EC50 nan None 10.1021/acs.jmedchem.6b01197
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor Activity 1.26 None 10.1073/pnas.0706980105
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Ataxin-2 Potency 19952.6 nM None
Homo sapiens Beta-1 adrenergic receptor AC50 593.5 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor EC50 0.084 nM 10.1016/j.bmcl.2004.11.001
Homo sapiens Beta-1 adrenergic receptor EC50 0.084 nM 10.1016/j.bmcl.2008.08.009
Homo sapiens Beta-1 adrenergic receptor EC50 0.084 nM 10.1021/jm701324c
Homo sapiens Beta-1 adrenergic receptor EC50 0.084 nM 10.1021/jm8000345
Homo sapiens Beta-1 adrenergic receptor EC50 0.084 nM 10.1021/jm800222k
Homo sapiens Beta-1 adrenergic receptor EC50 0.84 nM 10.1021/jm9000709
Homo sapiens Beta-1 adrenergic receptor EC50 1.0 nM 10.1021/jm0101500
Homo sapiens Beta-1 adrenergic receptor EC50 1.0 nM 10.1021/jm0509445
Homo sapiens Beta-1 adrenergic receptor EC50 1.259 nM 10.1016/j.ejmech.2021.113697
Homo sapiens Beta-1 adrenergic receptor EC50 3.162 nM 10.1016/j.bmc.2018.10.043
Homo sapiens Beta-1 adrenergic receptor EC50 3.162 nM 10.1016/j.ejmech.2018.04.041
Homo sapiens Beta-1 adrenergic receptor EC50 3.2 nM 10.1021/acs.jmedchem.6b01197
Homo sapiens Beta-1 adrenergic receptor EC50 7.943 nM 10.1016/j.bmc.2011.05.064
Homo sapiens Beta-1 adrenergic receptor EC50 7.943 nM 10.1016/j.bmc.2011.08.043
Homo sapiens Beta-1 adrenergic receptor EC50 7.943 nM 10.1021/jm100326d
Homo sapiens Beta-1 adrenergic receptor EC50 7.943 nM 10.1021/jm801016j
Homo sapiens Beta-1 adrenergic receptor EC50 12.0 nM 10.1016/j.bmc.2009.06.031
Homo sapiens Beta-1 adrenergic receptor EC50 12.0 nM 10.1016/j.ejmech.2009.01.022
Homo sapiens Beta-1 adrenergic receptor EC50 100.0 nM 10.1016/j.bmc.2009.03.044
Homo sapiens Beta-1 adrenergic receptor EC50 1000.0 nM 10.1016/j.bmc.2009.06.031
Homo sapiens Beta-1 adrenergic receptor EC50 1000.0 nM 10.1021/acs.jmedchem.1c02006
Homo sapiens Beta-1 adrenergic receptor Emax 109.0 % 10.1021/jm0101500
Homo sapiens Beta-1 adrenergic receptor Emax 109.0 % 10.1021/jm0509445
Homo sapiens Beta-1 adrenergic receptor IA 100.0 None 10.1021/jm990463j
Homo sapiens Beta-1 adrenergic receptor IC50 333.0 nM None
Homo sapiens Beta-1 adrenergic receptor Intrinsic activity 1.0 None 10.1016/j.ejmech.2009.01.022
Homo sapiens Beta-1 adrenergic receptor Intrinsic activity 100.0 None 10.1021/jm990012z
Homo sapiens Beta-1 adrenergic receptor Ki 193.0 nM None
Homo sapiens Beta-1 adrenergic receptor Ki 1584.89 nM 10.1021/jm990012z
Homo sapiens Beta-1 adrenergic receptor pK 8.81 None 10.1021/jm990463j
Homo sapiens Beta-1 adrenergic receptor pKact 8.75 None 10.1021/jm990012z
Homo sapiens Beta-2 adrenergic receptor AC50 19.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 928.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor Activity 100.0 % 10.1016/j.bmc.2013.11.030
Homo sapiens Beta-2 adrenergic receptor Activity nan None 10.1038/nchembio790
Homo sapiens Beta-2 adrenergic receptor EC50 0.1585 nM 10.1021/jm0101500
Homo sapiens Beta-2 adrenergic receptor EC50 0.1585 nM 10.1021/jm0509445
Homo sapiens Beta-2 adrenergic receptor EC50 0.2 nM 10.1016/j.bmc.2013.11.030
Homo sapiens Beta-2 adrenergic receptor EC50 0.2138 nM 10.1016/j.ejmech.2021.113697
Homo sapiens Beta-2 adrenergic receptor EC50 0.3162 nM 10.1016/j.bmc.2018.10.043
Homo sapiens Beta-2 adrenergic receptor EC50 0.3162 nM 10.1016/j.ejmech.2018.04.041
Homo sapiens Beta-2 adrenergic receptor EC50 0.7 nM 10.1021/acs.jnatprod.7b00762
Homo sapiens Beta-2 adrenergic receptor EC50 0.84 nM 10.1016/j.bmcl.2009.06.083
Homo sapiens Beta-2 adrenergic receptor EC50 1.2 nM 10.1021/acs.jnatprod.9b00418
Homo sapiens Beta-2 adrenergic receptor EC50 2.0 nM 10.1016/j.bmcl.2004.11.001
Homo sapiens Beta-2 adrenergic receptor EC50 2.0 nM 10.1021/jm8000345
Homo sapiens Beta-2 adrenergic receptor EC50 2.0 nM 10.1021/jm800222k
Homo sapiens Beta-2 adrenergic receptor EC50 2.0 nM 10.1021/jm9000709
Homo sapiens Beta-2 adrenergic receptor EC50 3.0 nM 10.1016/j.bmc.2009.03.044
Homo sapiens Beta-2 adrenergic receptor EC50 3.0 nM 10.1016/j.bmc.2009.06.031
Homo sapiens Beta-2 adrenergic receptor EC50 3.0 nM 10.1016/j.ejmech.2009.01.022
Homo sapiens Beta-2 adrenergic receptor EC50 5.954 nM 10.1021/acs.jmedchem.1c02006
Homo sapiens Beta-2 adrenergic receptor EC50 13.0 nM 10.1021/acs.jmedchem.6b01197
Homo sapiens Beta-2 adrenergic receptor EC50 39.81 nM 10.1016/j.bmc.2011.05.064
Homo sapiens Beta-2 adrenergic receptor EC50 39.81 nM 10.1016/j.bmc.2011.08.043
Homo sapiens Beta-2 adrenergic receptor EC50 39.81 nM 10.1016/j.bmcl.2011.04.135
Homo sapiens Beta-2 adrenergic receptor EC50 39.81 nM 10.1021/jm100326d
Homo sapiens Beta-2 adrenergic receptor EC50 39.81 nM 10.1021/jm801016j
Homo sapiens Beta-2 adrenergic receptor EC50 87.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Beta-2 adrenergic receptor EC50 120.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Beta-2 adrenergic receptor EC50 1000.0 nM 10.1016/j.bmc.2009.06.031
Homo sapiens Beta-2 adrenergic receptor Efficacy 1.0 None 10.1021/jm00150a036
Homo sapiens Beta-2 adrenergic receptor Emax 100.0 % 10.1016/j.bmc.2016.04.028
Homo sapiens Beta-2 adrenergic receptor Emax 116.0 % 10.1021/jm0101500
Homo sapiens Beta-2 adrenergic receptor Emax 116.0 % 10.1021/jm0509445
Homo sapiens Beta-2 adrenergic receptor IA 100.0 None 10.1021/jm990463j
Homo sapiens Beta-2 adrenergic receptor IC50 246.0 nM None
Homo sapiens Beta-2 adrenergic receptor Inhibition nan % 10.1016/j.bmcl.2009.01.057
Homo sapiens Beta-2 adrenergic receptor Intrinsic activity 1.0 None 10.1016/j.bmc.2011.05.064
Homo sapiens Beta-2 adrenergic receptor Intrinsic activity 1.0 None 10.1016/j.bmc.2011.08.043
Homo sapiens Beta-2 adrenergic receptor Intrinsic activity 1.0 None 10.1016/j.bmcl.2011.04.135
Homo sapiens Beta-2 adrenergic receptor Intrinsic activity 1.0 None 10.1016/j.ejmech.2009.01.022
Homo sapiens Beta-2 adrenergic receptor Intrinsic activity 1.0 None 10.1021/jm100326d
Homo sapiens Beta-2 adrenergic receptor Intrinsic activity 100.0 % 10.1016/j.ejmech.2021.113697
Homo sapiens Beta-2 adrenergic receptor Intrinsic activity 100.0 None 10.1021/jm990012z
Homo sapiens Beta-2 adrenergic receptor Kd 50.0 nM 10.1016/j.ejmech.2008.12.016
Homo sapiens Beta-2 adrenergic receptor Kd 130.0 nM 10.1021/acs.jmedchem.6b00358
Homo sapiens Beta-2 adrenergic receptor Kd 251.19 nM 10.1016/j.bmcl.2013.07.052
Homo sapiens Beta-2 adrenergic receptor Kd 740.0 nM 10.1021/acs.jmedchem.6b00358
Homo sapiens Beta-2 adrenergic receptor Ki 2.44 nM 10.1016/j.bmc.2013.11.030
Homo sapiens Beta-2 adrenergic receptor Ki 46.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Beta-2 adrenergic receptor Ki 169.0 nM None
Homo sapiens Beta-2 adrenergic receptor Ki 192.0 nM 10.1016/j.bmc.2013.11.030
Homo sapiens Beta-2 adrenergic receptor Ki 676.08 nM 10.1021/jm990012z
Homo sapiens Beta-2 adrenergic receptor Km 50.0 nM 10.1021/jm00150a036
Homo sapiens Beta-2 adrenergic receptor log K 0.8 None 10.1021/acs.jmedchem.6b00358
Homo sapiens Beta-2 adrenergic receptor pK 9.46 None 10.1021/jm990463j
Homo sapiens Beta-2 adrenergic receptor pKact 8.4 None 10.1021/jm990012z
Homo sapiens Beta-2 adrenergic receptor Potency 1299.5 nM None
Homo sapiens Beta-2 adrenergic receptor and beta-3 adrenergic receptor Ratio 2.1 None 10.1016/j.bmcl.2004.11.001
Homo sapiens Beta-2 adrenergic receptor and beta-3 adrenergic receptor Ratio EC50 0.1 None 10.1021/jm0509445
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor EC50 0.97 nM 10.1016/j.bmcl.2004.11.001
Homo sapiens Beta-3 adrenergic receptor EC50 0.97 nM 10.1016/j.bmcl.2008.08.009
Homo sapiens Beta-3 adrenergic receptor EC50 0.97 nM 10.1021/jm701324c
Homo sapiens Beta-3 adrenergic receptor EC50 0.97 nM 10.1021/jm8000345
Homo sapiens Beta-3 adrenergic receptor EC50 0.97 nM 10.1021/jm800222k
Homo sapiens Beta-3 adrenergic receptor EC50 0.97 nM 10.1021/jm9000709
Homo sapiens Beta-3 adrenergic receptor EC50 2.0 nM 10.1016/j.bmcl.2009.06.083
Homo sapiens Beta-3 adrenergic receptor EC50 3.162 nM 10.1021/jm0101500
Homo sapiens Beta-3 adrenergic receptor EC50 3.162 nM 10.1021/jm0509445
Homo sapiens Beta-3 adrenergic receptor EC50 3.9 nM 10.1016/j.bmc.2007.11.060
Homo sapiens Beta-3 adrenergic receptor EC50 5.8 nM 10.1016/j.bmc.2007.11.060
Homo sapiens Beta-3 adrenergic receptor EC50 12.0 nM 10.1016/j.bmc.2009.03.044
Homo sapiens Beta-3 adrenergic receptor EC50 39.81 nM 10.1016/j.bmc.2011.05.064
Homo sapiens Beta-3 adrenergic receptor EC50 39.81 nM 10.1016/j.bmc.2011.08.043
Homo sapiens Beta-3 adrenergic receptor EC50 39.81 nM 10.1021/jm100326d
Homo sapiens Beta-3 adrenergic receptor EC50 39.81 nM 10.1021/jm801016j
Homo sapiens Beta-3 adrenergic receptor EC50 53.7 nM 10.1016/j.ejmech.2018.04.041
Homo sapiens Beta-3 adrenergic receptor EC50 86.0 nM 10.1021/acs.jmedchem.5b00638
Homo sapiens Beta-3 adrenergic receptor EC50 86.0 nM 10.1021/acs.jmedchem.6b01197
Homo sapiens Beta-3 adrenergic receptor EC50 87.0 nM 10.1021/jm020177z
Homo sapiens Beta-3 adrenergic receptor EC50 87.1 nM 10.1021/jm020177z
Homo sapiens Beta-3 adrenergic receptor EC50 100.0 nM 10.1016/j.bmc.2009.06.031
Homo sapiens Beta-3 adrenergic receptor EC50 100.0 nM 10.1016/j.ejmech.2009.01.022
Homo sapiens Beta-3 adrenergic receptor EC50 1000.0 nM 10.1016/j.bmc.2009.06.031
Homo sapiens Beta-3 adrenergic receptor EC50 1000.0 nM 10.1016/S0960-894X(96)00603-8
Homo sapiens Beta-3 adrenergic receptor Emax 112.0 % 10.1021/jm0101500
Homo sapiens Beta-3 adrenergic receptor Emax 112.0 % 10.1021/jm0509445
Homo sapiens Beta-3 adrenergic receptor IA 100.0 None 10.1021/jm990463j
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Intrinsic activity 0.88 None 10.1021/jm800222k
Homo sapiens Beta-3 adrenergic receptor Intrinsic activity 1.0 None 10.1016/j.ejmech.2009.01.022
Homo sapiens Beta-3 adrenergic receptor Intrinsic activity 1.0 None 10.1016/S0960-894X(96)00603-8
Homo sapiens Beta-3 adrenergic receptor Intrinsic activity 1.0 None 10.1021/jm8000345
Homo sapiens Beta-3 adrenergic receptor Intrinsic activity 100.0 % 10.1016/j.bmc.2007.11.060
Homo sapiens Beta-3 adrenergic receptor Intrinsic activity 100.0 None 10.1021/jm990012z
Homo sapiens Beta-3 adrenergic receptor Ki 18620.87 nM 10.1021/jm990012z
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor pK 7.74 None 10.1021/jm990463j
Homo sapiens Beta-3 adrenergic receptor pKact 7.37 None 10.1021/jm990012z
Homo sapiens Beta-3 adrenergic receptor Ratio 1.0 None 10.1021/jm701324c
Homo sapiens Bile salt export pump IC50 986200.0 nM 10.1124/dmd.112.047068
Homo sapiens Bile salt export pump IC50 1000000.0 nM 10.1124/dmd.111.040758
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 10.6 nM None
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 FC 11.8 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 FC 100.1 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 FC 135.8 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki 50000.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor EC50 nan None 10.1016/j.bmc.2016.04.028
Homo sapiens Dopamine D2 receptor Emax nan None 10.1016/j.bmc.2016.04.028
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki 12000.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Dopamine D2 receptor Ki 48000.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki 4700.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki 2900.0 nM 10.1016/j.bmc.2016.04.028
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 33498.3 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glutaminase kidney isoform, mitochondrial Potency 11220.2 nM None
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -32.65 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 0.29 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 14125.4 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsomes FC nan None 10.1016/j.bmc.2011.08.043
Homo sapiens Liver microsomes Ratio nan None 10.1016/j.bmc.2011.05.064
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Microtubule-associated protein tau Potency 7943.3 nM None
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 20596.2 nM None
Homo sapiens PC-3 FC 0.955 None 10.1038/nchembio790
Homo sapiens Phosphodiesterase 3A AC50 17999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma fCmax 0.0005 uM 10.1124/dmd.111.040758
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens POU domain, class 2, transcription factor 1 Activity nan None 10.1021/acs.jmedchem.2c01075
Homo sapiens POU domain, class 2, transcription factor 2 Activity nan None 10.1021/acs.jmedchem.2c01075
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 168.3 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 42284.1 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 13091.8 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 18492.7 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Skin log Kp -8.25 None 10.1016/j.bmc.2007.07.050
Homo sapiens Solute carrier family 22 member 3 Activity nan None 10.1021/acs.jmedchem.2c01075
Homo sapiens Taste receptor type 2 member 1 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 10 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 13 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 14 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 16 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 19 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 20 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 3 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 30 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 31 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 38 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 39 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 4 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 40 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 41 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 42 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 43 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 45 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 46 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 5 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 50 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 60 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 7 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 8 EC50 4.9 nM None
Homo sapiens Taste receptor type 2 member 9 EC50 4.9 nM None
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 100000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 26608.6 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 79432.8 nM None
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Potency 23934.1 nM None
Meleagris gallopavo Erythrocyte beta receptor Delta G -9.18 None 10.1021/jm00152a017
Mus musculus 3T3-L1 Activity 322.0 % 10.1016/j.bmc.2017.07.032
Mus musculus 3T3-L1 Activity nan None 10.1021/np400520a
Mus musculus Beta-1 adrenergic receptor Ki 220.0 nM 10.1016/j.bmc.2016.04.028
Mus musculus Beta-adrenergic receptor EC50 980.0 nM 10.1021/jm50001a017
Mus musculus C3H 10T1/2 Activity 291.3 % 10.1016/j.bmcl.2011.01.120
Mus musculus C3H 10T1/2 EC50 19.0 nM 10.1016/j.bmcl.2011.01.120
Mus musculus Heart Activity -5882.0 cmH2O/ms 10.1021/jm301303p
Mus musculus Heart Activity 157.0 cmH2O 10.1021/jm301303p
Mus musculus Heart Activity 334.0 bpm 10.1021/jm301303p
Mus musculus Heart Activity 5330.0 cmH2O/ms 10.1021/jm301303p
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mustela putorius furo Mustela putorius furo EC50 87.1 nM 10.1021/jm000455z
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 1770.0 nM None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium falciparum Plasmodium falciparum Potency 4256.2 nM None
Plasmodium falciparum Plasmodium falciparum Potency 15101.4 nM None
Rattus norvegicus Adrenergic receptor alpha IC50 100000.0 nM 10.1021/jm00348a014
Rattus norvegicus Adrenergic receptor alpha pD2 3.5 None 10.1021/jm00155a025
Rattus norvegicus Adrenergic receptor alpha-1 IA 0.83 None 10.1021/jm00073a006
Rattus norvegicus Adrenergic receptor alpha-1 Intrinsic activity 0.83 None 10.1021/jm00084a006
Rattus norvegicus Adrenergic receptor alpha-1 Ki 35500.0 nM 10.1021/jm00073a006
Rattus norvegicus Adrenergic receptor alpha-1 Ki 35500.0 nM 10.1021/jm00084a006
Rattus norvegicus Adrenergic receptor alpha-1 pD2 3.5 None 10.1021/jm00073a006
Rattus norvegicus Adrenergic receptor alpha-1 pD2 3.5 None 10.1021/jm00084a006
Rattus norvegicus Adrenergic receptor alpha-2 Ki 21000.0 nM 10.1021/jm00073a006
Rattus norvegicus Adrenergic receptor alpha-2 Ki 21000.0 nM 10.1021/jm00084a006
Rattus norvegicus Adrenergic receptor beta EC50 7.0 nM 10.1021/jm00107a027
Rattus norvegicus Adrenergic receptor beta IC50 100.0 nM 10.1021/jm00348a014
Rattus norvegicus Adrenergic receptor beta IC50 325.0 nM 10.1021/jm00392a006
Rattus norvegicus Adrenergic receptor beta max activation 65.0 pmol/mg/min 10.1021/jm00209a019
Rattus norvegicus Adrenergic receptor beta max activation 950.0 pmol 10.1021/jm00209a019
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Beta-1 adrenergic receptor EC20 0.15 nM 10.1021/jm020177z
Rattus norvegicus Beta-1 adrenergic receptor Efficacy 1.0 None 10.1021/jm00150a036
Rattus norvegicus Beta-1 adrenergic receptor IC50 5.3 nM 10.1021/jm00094a025
Rattus norvegicus Beta-1 adrenergic receptor IC50 600.0 nM 10.1021/jm00094a025
Rattus norvegicus Beta-1 adrenergic receptor Ki 80.0 nM 10.1021/jm00073a006
Rattus norvegicus Beta-1 adrenergic receptor Ki 80.0 nM 10.1021/jm00084a006
Rattus norvegicus Beta-1 adrenergic receptor Ki 670.0 nM 10.1021/jm00107a027
Rattus norvegicus Beta-1 adrenergic receptor Km 32000.0 nM 10.1021/jm00150a036
Rattus norvegicus Beta-1 adrenergic receptor -Log EC20 9.82 None 10.1021/jm000455z
Rattus norvegicus Beta-1 adrenergic receptor pEC20 9.82 None 10.1021/jm020177z
Rattus norvegicus Beta-2 adrenergic receptor IC50 0.1 nM 10.1021/jm020177z
Rattus norvegicus Beta-3 adrenergic receptor EC50 13.0 nM 10.1021/jm00094a025
Rattus norvegicus Beta-3 adrenergic receptor EC50 87.1 nM 10.1021/jm000455z
Rattus norvegicus Beta-3 adrenergic receptor ED50 0.16 mg.kg-1 10.1021/jm00088a009
Rattus norvegicus Beta-3 adrenergic receptor Intrinsic activity 0.99 None 10.1021/jm000455z
Rattus norvegicus Beta-3 adrenergic receptor SI 0.06 beats min-1 10.1021/jm00088a009
Rattus norvegicus Bile salt export pump IC50 1000000.0 nM 10.1124/dmd.111.040758
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Peripheral myelin protein 22 Potency 907.4 nM None
Rattus norvegicus Rattus norvegicus Activity 13.64 pmol/Kg 10.1021/acs.jmedchem.1c02006
Rattus norvegicus Rattus norvegicus Activity 27.93 pmol/g 10.1021/acs.jmedchem.1c02006
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00223a039
Rattus norvegicus Rattus norvegicus ALB 36000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 36300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 37300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 37700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 44000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 244.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 260.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 282.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 291.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 303.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 310.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 319.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 326.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 331.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 333.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 336.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 337.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 349.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 367.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 368.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 369.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 370.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 385.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 400.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 424.4 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 30.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 32.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 33.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 34.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 38.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 39.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 39.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 40.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 40.6 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 41.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 42.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 47.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 50.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 53.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 55.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 57.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 62.75 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 81.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 62.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 65.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 68.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 72.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 73.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 74.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 74.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 75.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 75.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 76.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 78.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 79.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.25 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 84.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 86.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 86.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 87.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 98.2 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0133 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0233 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0267 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0333 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.05 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0533 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.06 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.095 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.2 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.37 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.42 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 4.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 4.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BP -31.0 mmHg 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus BP -20.0 mmHg 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus BUN 115.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 133.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 146.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 153.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 155.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 165.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 166.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 170.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 173.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 176.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 192.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 193.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 201.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.75 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 106.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 106.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 107.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 107.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 108.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 570.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 613.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 653.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 656.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 696.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 715.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 734.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 743.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 750.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 757.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 773.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 803.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 843.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 856.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 863.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 875.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 896.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 1050.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 183.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 190.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 190.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 196.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 262.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 274.2 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 281.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 282.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 286.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 334.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 449.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 38800000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 39670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 40500000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 40670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 41330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 42670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 43000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Conversion 0.84 % 10.1021/jm00151a001
Rattus norvegicus Rattus norvegicus CREAT 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 4.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 4.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 5.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 5.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 5.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 6.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 7.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 8.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus dP/dt 9844.0 mmHg s-1 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus EC50 10.0 nM 10.1021/jm000455z
Rattus norvegicus Rattus norvegicus EC50 226.0 nM 10.1021/jm00392a006
Rattus norvegicus Rattus norvegicus ED50 0.0006 mg.kg-1 10.1021/jm000455z
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0333 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0367 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.05 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0533 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0567 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.095 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.11 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 26.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 46.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 47.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 59.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 64.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 77.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 84.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 89.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 134.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.55 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.72 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 993.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1316.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1320.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1368.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1403.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1410.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1440.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1496.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1513.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1520.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1523.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1526.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1540.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1566.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1616.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1656.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1683.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1798.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1823.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 30.7 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.97 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.52 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.65 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.22 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.77 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.93 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.95 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 41.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 42.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 43.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 44.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 44.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 44.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 45.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Heart rate 46.0 beats min-1 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus HGB 114700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 117700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 121300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 125700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 126800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 128500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 128800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 130000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 131800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 136000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 137700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 143700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 147300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus IA 1.0 None 10.1021/jm00392a006
Rattus norvegicus Rattus norvegicus LDH 80.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 93.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 103.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 104.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 122.25 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 126.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 128.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 140.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 147.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 151.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 156.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 159.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 162.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 214.4 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 289.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 293.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.75 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.8 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 24.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 29.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 47.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 99.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 214.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 268.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 4.96 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7.49 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8.34 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8.92 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9.92 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10.37 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11.58 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12.99 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9880.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10985.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11630.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12507.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12693.75 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13359.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13411.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14257.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14293.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14556.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15188.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15742.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 71.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 72.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 72.93 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 73.55 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 74.03 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 78.08 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 78.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 80.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 80.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 80.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 81.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 82.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 83.25 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 84.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.03 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.23 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.5 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.63 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.18 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.3 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.42 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.62 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 22.1 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 22.2 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 22.38 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 22.5 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 22.95 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.03 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.53 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.6 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.0 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 300500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 301700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 310300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 316700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 319300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 319700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 321200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 331700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 362700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 364200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 364300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 367000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 367800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 368000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 368300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 371500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 373300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 374700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 389000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 58.17 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.37 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.6 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.67 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.18 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.73 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.75 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.07 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.1 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.2 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.83 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 68.3 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 68.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.15 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.2 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.23 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.24 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.3 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.35 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.42 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 224.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 232.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 234.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 270.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 299.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 326.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 354.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 380.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 389.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 404.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 445.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 485.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.94 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.1 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.13 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.35 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.25 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 4.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 12.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 14.03 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 15.07 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 16.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 16.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 17.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 18.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 18.22 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 22.05 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 22.1 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 22.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 23.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 26.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 800.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 850.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 972.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1159.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1658.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1753.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1854.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2010.75 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2414.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2701.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 3216.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 3561.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 96.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 98.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 98.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 99.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 100.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 101.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 101.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 102.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 109.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 112.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 117.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 122.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 131.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 133.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 134.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 145.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 679170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 856500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 904670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1016000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1074600.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1122670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1142670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1159000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1167670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1170500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1202000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1247670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1265330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1299670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1301330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1311000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1372000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1375330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1573330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.73 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.81 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.92 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.93 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.97 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.02 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.05 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.08 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.55 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.71 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.73 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.86 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.05 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.09 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 64000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 64600.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5170000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5330000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5500000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5600000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5610000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5640000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5650000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5660000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5780000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5800000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6100000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6110000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6250000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6270000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6360000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6690000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6810000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6910000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7350000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.5 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.37 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.85 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.52 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.78 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.07 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.27 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 149.2 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 149.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 150.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 150.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 8.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 8.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 9.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 10.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 19.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 21.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 22.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 23.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 24.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 6690.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9070.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11200.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11550.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12090.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13730.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14260.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14870.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14900.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15150.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15370.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15700.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16380.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16800.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 17800.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 17820.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 9466.2 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 14125.4 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1056 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Trypanosoma brucei 6-phospho-1-fructokinase Potency 849.2 nM None
None Adipocyte Activity 214.39 % 10.1016/j.bmcl.2011.01.120
None ADMET CL 56.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 112.3 mL.min-1.kg-1 10.1016/j.ejmech.2018.04.041
None ADMET delta logD -0.88 None 10.1021/jm0000564
None ADMET ED25 3.4 nM 10.1021/jm00218a008
None ADMET F 49.0 % 10.1021/jm0000564
None ADMET MRT 0.43 hr 10.1124/dmd.108.020479
None ADMET T1/2 0.205 hr 10.1016/j.ejmech.2018.04.041
None ADMET T1/2 0.41 hr 10.1124/dmd.108.020479
None ADMET Vdss 1.5 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LTKB_BD DILI severity score nan None 10.1016/j.drudis.2011.05.007
None NON-PROTEIN TARGET Fu 0.71 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Inhibition 49.0 % 10.1021/jm00190a003
None NON-PROTEIN TARGET Potency 5951.8 nM None
None No relevant target LogD -2.76 None 10.1021/jm0000564
None No relevant target LogP 0.0 None 10.1021/jm00227a010
None No relevant target pKa 8.65 None 10.1007/s11095-013-1232-z
None No relevant target pKa 8.7 None 10.1021/jm0000564
None Unchecked Ac50 0.631 uM None
None Unchecked Ac50 1.413 uM None
None Unchecked Ac50 1.778 uM None
None Unchecked Ac50 2.239 uM None
None Unchecked Ac50 4.467 uM None
None Unchecked AC50 631.0 nM None
None Unchecked AC50 1412.5 nM None
None Unchecked AC50 1778.3 nM None
None Unchecked AC50 1780.0 nM None
None Unchecked AC50 2238.7 nM None
None Unchecked AC50 4466.8 nM None
None Unchecked Activity 0.3 mM 10.1021/jm00214a028
None Unchecked Activity 3.12 umol 10.1021/jm00214a028
None Unchecked Activity 48.0 % 10.1038/nchembio801
None Unchecked Activity nan None 10.1016/j.bmcl.2013.07.052
None Unchecked Activity nan None 10.1038/nchembio801
None Unchecked [A]T,L 4.47 10'-8 /no of units.cm'3 10.1016/j.bmc.2008.12.063
None Unchecked [A]T,L 9728.0 /mol.dm'3 10.1016/j.bmc.2008.12.063
None Unchecked EC50 199526231.5 nM 10.1021/jm801016j
None Unchecked EC50 1000000000.0 nM 10.1021/jm801016j
None Unchecked ED25 3.4 10'-9M 10.1021/jm00220a600
None Unchecked ED50 7.1 10'-9M 10.1021/jm00220a600
None Unchecked ED50 7.1 nM 10.1021/jm00218a008
None Unchecked Emax 180.57 % 10.1016/j.ejmech.2021.113697
None Unchecked IC50 150.0 nM 10.1038/nchembio801
None Unchecked IC50 370.0 nM 10.1038/nchembio801
None Unchecked IC50 nan None None
None Unchecked KA 1.2e-07 M 10.1021/jm50001a017
None Unchecked Kd 9.8e-07 None 10.1021/jm50001a017
None Unchecked Ki 50.0 nM 10.1038/nchembio801
None Unchecked Ki 90.0 nM 10.1038/nchembio801
None Unchecked Ki 5700.0 nM 10.1016/j.bmc.2016.04.028
None Unchecked Ki 78000.0 nM 10.1016/j.bmc.2016.04.028
None Unchecked Ki nan None None
None Unchecked pD2 7.84 None 10.1016/j.ejmech.2021.113697
None Unchecked Potency 410.8 nM None
None Unchecked Potency 3162.3 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Ratio 0.087 None 10.1021/jm800222k
None Unchecked Ratio 0.1 None 10.1021/jm0101500
None Unchecked Ratio 0.3 None 10.1021/jm0101500
None Unchecked Ratio 0.48 None 10.1021/jm00218a008
None Unchecked Ratio 0.99 None 10.1016/j.ejmech.2018.04.041
None Unchecked Ratio 0.99 None 10.1021/jm020177z
None Unchecked Ratio 1.0 None 10.1021/jm00199a013
None Unchecked Ratio 1.0 None 10.1021/jm00218a008
None Unchecked Ratio EC50 0.087 None 10.1016/j.bmcl.2008.08.009
None Unchecked Ratio EC50 0.087 None 10.1021/jm701324c
None Unchecked Ratio EC50 0.087 None 10.1021/jm8000345
None Unchecked Ratio EC50 2.1 None 10.1021/jm8000345
None Unchecked Ratio EC50 168.0 None 10.1021/acs.jmedchem.1c02006
None Unchecked Ratio Ki 260.0 None 10.1016/j.bmc.2016.04.028
None Unchecked Selectivity 0.001 None 10.1021/jm000455z
None Unchecked Selectivity 0.001 None 10.1021/jm020177z
None Unchecked Selectivity 0.002 None 10.1021/jm000455z
None Unchecked Selectivity 0.002 None 10.1021/jm020177z
None Unchecked Selectivity ratio 0.48 None 10.1021/jm00220a007
None Unchecked Selectivity ratio 0.48 None 10.1021/jm00220a600
None Unchecked Selectivity ratio 0.77 None 10.1016/j.ejmech.2021.113697
None Unchecked Selectivity ratio 0.99 None 10.1016/j.bmc.2018.10.043

Metabolism Information