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name Structure Reference Source Properties Activities Metabolism

None

AlkaPlorer ID: AK323719

Synonym: None

IUPAC Name: (Z)-N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitrofuran-2-yl)methanimine

Structure

SMILES: CC1CS(=O)(=O)CCN1/N=C/C1=CC=C([N+](=O)[O-])O1

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InChI: InChI=1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+

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InChIKey: ARFHIAQFJWUCFH-IZZDOVSWSA-N

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Reference

PubChem CID: 6842999

CAS: 23256-30-6

NPASS: NPC484338

Source

Species Genus Family Order Class Phylum Kingdom Domain
Oxandra espintana Oxandra Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 287.297

TPSA？: 106.02

MolLogP？: 0.6406000000000001

Number of H-Donors: 0

Number of H-Acceptors: 7

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 12.66 % 10.6019/CHEMBL4513149
Candida albicans Candida albicans Inhibition 4.12 % 10.6019/CHEMBL4513149
Chlorocebus sabaeus Vero CC50 32000.0 nM 10.1016/j.bmcl.2017.05.071
Chlorocebus sabaeus Vero CC50 61420.0 nM 10.1016/j.bmc.2010.05.018
Chlorocebus sabaeus Vero CC50 67500.0 nM 10.1016/j.ejmech.2014.08.055
Chlorocebus sabaeus Vero CC50 113600.0 nM 10.1016/j.bmcl.2008.05.013
Chlorocebus sabaeus Vero CC50 163000.0 nM 10.1016/j.ejmech.2015.04.028
Chlorocebus sabaeus Vero CC90 300.0 uM 10.1016/j.bmc.2010.05.018
Chlorocebus sabaeus Vero CC90 300.0 uM 10.1016/j.bmcl.2008.05.013
Chlorocebus sabaeus Vero EC50 50000.0 nM 10.1016/j.bmcl.2018.04.064
Chlorocebus sabaeus Vero EC50 50118.72 nM 10.1021/acs.jmedchem.7b00463
Chlorocebus sabaeus Vero IC50 64110.0 nM 10.1128/aac.00800-10
Chlorocebus sabaeus Vero IC50 80100.0 nM 10.1021/jm800812k
Chlorocebus sabaeus Vero IC50 94000.0 nM 10.1016/j.bmc.2010.03.018
Chlorocebus sabaeus Vero IC50 115000.0 nM 10.1021/acsmedchemlett.8b00247
Chlorocebus sabaeus Vero IC50 411130.0 nM 10.1016/j.bmc.2014.07.030
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np049890c
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np070081d
Cricetulus griseus CHO GI50 13.9 ug.mL-1 10.1021/np300067m
Cricetulus griseus V79 IC50 35000.0 nM 10.1128/aac.00800-10
Cryptococcus neoformans Cryptococcus neoformans Inhibition 5.99 % 10.6019/CHEMBL4513149
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.bmc.2016.08.036
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.ejmech.2015.10.007
Escherichia coli Escherichia coli Inhibition 6.0 % 10.6019/CHEMBL4513149
Escherichia coli GroEL/GroES IC50 100000.0 nM 10.1016/j.bmcl.2016.09.051
Escherichia coli GroEL/GroES IC50 250000.0 nM 10.1016/j.bmcl.2016.09.051
Giardia intestinalis Giardia intestinalis IC50 nan None 10.1016/j.bmcl.2017.05.071
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Caco-2 Activity 40.0 % 10.1016/j.bmc.2009.10.030
Homo sapiens Cathepsin B Inhibition nan % 10.1021/jm900629w
Homo sapiens Cathepsin B Ki nan None 10.1021/jm900629w
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ferrochelatase, mitochondrial Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HeLa EC50 91200.0 nM 10.1021/jm301215e
Homo sapiens HeLa EC50 272000.0 nM 10.1016/j.ejmech.2016.10.055
Homo sapiens HeLa IC50 12000.0 nM 10.1016/j.bmc.2009.01.011
Homo sapiens HepG2 CC50 45200.0 nM 10.1016/j.ejmech.2020.112558
Homo sapiens HepG2 CC50 45200.0 nM 10.1016/j.ejmech.2020.112668
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HFF IC50 nan None 10.1021/np030010o
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -9.63 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 0.97 % 10.6019/CHEMBL4808148
Homo sapiens Homo sapiens IC50 nan nM 10.1016/j.bmcl.2004.05.026
Homo sapiens Homo sapiens Inhibition nan % 10.1016/j.bmcl.2004.05.026
Homo sapiens HSP60/HSP10 IC50 100000.0 nM 10.1016/j.bmcl.2016.09.051
Homo sapiens HSP60/HSP10 IC50 250000.0 nM 10.1016/j.bmcl.2016.09.051
Homo sapiens IMR-90 EC50 25000.0 nM 10.1016/j.bmcl.2017.01.043
Homo sapiens MCF7 IC50 nan None 10.1021/np070081d
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MRC5 CC50 50000.0 nM 10.1016/s0960-894x(02)00788-6
Homo sapiens MRC5 IC50 nan nM 10.1016/j.bmcl.2004.05.026
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens NCI-H460 IC50 nan None 10.1021/np070081d
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Porphobilinogen deaminase Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum Drug uptake 3.0 uM 10.1128/aac.00332-10
Homo sapiens THP-1 CC50 nan None 10.1016/j.bmcl.2008.05.013
Homo sapiens THP-1 CC90 nan None 10.1016/j.bmcl.2008.05.013
Homo sapiens THP-1 IC50 64800.0 nM 10.1128/aac.01213-09
Homo sapiens THP-1 IC50 100000.0 nM 10.1016/j.bmcl.2013.09.047
Homo sapiens THP-1 ID50 300.0 uM 10.1016/j.ejmech.2007.06.020
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens U2OS CC50 85190.0 nM 10.1016/j.ejmech.2017.12.011
Homo sapiens U2OS CC50 97200.0 nM 10.1016/j.ejmech.2015.12.045
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 15.43 % 10.6019/CHEMBL4513149
Leishmania amazonensis Leishmania amazonensis EC50 800.0 nM 10.1016/j.bmcl.2017.01.043
Leishmania amazonensis Leishmania amazonensis IC50 nan nM 10.1016/j.bmcl.2004.05.026
Leishmania amazonensis Leishmania amazonensis IC50 nan None 10.1016/j.bmcl.2017.05.071
Leishmania chagasi Leishmania chagasi IC50 nan None 10.1016/j.bmcl.2008.05.013
Leishmania chagasi Leishmania chagasi IC90 nan None 10.1016/j.bmcl.2008.05.013
Leishmania donovani Leishmania donovani EC50 4.0 nM 10.1021/acs.jnatprod.8b00159
Leishmania donovani Leishmania donovani EC50 24.0 nM 10.1021/acs.jnatprod.8b00159
Leishmania donovani Leishmania donovani IC50 110.0 nM 10.1021/acsmedchemlett.1c00193
Leishmania donovani Leishmania donovani IC50 1890.0 nM 10.1021/acsmedchemlett.1c00193
Leishmania donovani Leishmania donovani IC50 68000.0 nM 10.1021/jm050177+
Leishmania donovani Leishmania donovani IC50 nan None 10.1021/np070081d
Leishmania infantum Leishmania infantum IC50 6000.0 nM 10.1039/d0md00073f
Leishmania infantum Leishmania infantum IC50 6300.0 nM 10.1039/d0md00073f
Leishmania infantum Leishmania infantum IC50 6500.0 nM 10.1039/d0md00073f
Leishmania infantum Leishmania infantum IC50 6700.0 nM 10.1039/d0md00073f
Leishmania infantum Leishmania infantum IC50 nan nM 10.1016/j.bmcl.2004.05.026
Leishmania mexicana Leishmania mexicana IC50 3100.0 nM 10.1016/j.bmcl.2017.05.071
Leishmania mexicana Leishmania mexicana IC50 nan None 10.1016/j.ejmech.2019.02.028
Leishmania mexicana Leishmania mexicana LC50 nan None 10.1016/j.ejmech.2015.04.028
Mus musculus J774 Activity 0.0 % 10.1016/j.bmc.2014.01.036
Mus musculus J774 Activity 0.0 % 10.1016/j.bmcl.2005.12.087
Mus musculus J774 Activity 0.0 % 10.1016/j.ejmech.2011.04.057
Mus musculus J774 Activity 0.6 % 10.1016/j.bmc.2014.01.036
Mus musculus J774 Activity 0.6 % 10.1016/j.bmcl.2005.12.087
Mus musculus J774 Activity 0.6 % 10.1016/j.ejmech.2011.04.057
Mus musculus J774 Activity 25.9 % 10.1016/j.bmc.2014.01.036
Mus musculus J774 Activity 25.9 % 10.1016/j.bmcl.2005.12.087
Mus musculus J774 Activity 25.9 % 10.1016/j.ejmech.2011.04.057
Mus musculus J774 CC50 131500.0 nM 10.1016/j.bmcl.2017.06.013
Mus musculus J774 CC50 131503.0 nM 10.1016/j.bmcl.2015.08.018
Mus musculus J774 EC50 150000.0 nM 10.1039/C9MD00064J
Mus musculus J774 GI 0.0 % 10.1016/j.ejmech.2012.10.009
Mus musculus J774 GI 5.0 % 10.1016/j.ejmech.2012.10.009
Mus musculus J774 GI 25.02 % 10.1016/j.ejmech.2012.10.009
Mus musculus J774 IC50 200000.0 nM 10.1016/j.bmcl.2006.02.026
Mus musculus J774 IC50 280480.0 nM 10.1016/j.bmc.2013.06.017
Mus musculus J774 IC50 316000.0 nM 10.1016/j.bmcl.2014.06.044
Mus musculus J774 IC50 316000.0 nM 10.1016/j.ejmech.2013.04.065
Mus musculus J774 IC50 316000.0 nM 10.1016/j.ejmech.2017.04.075
Mus musculus J774 ID50 316.0 uM 10.1016/j.bmc.2009.09.013
Mus musculus J774 ID50 316.0 uM 10.1016/j.ejmech.2010.01.052
Mus musculus J774 ID50 346.0 uM 10.1016/j.ejmech.2009.06.014
Mus musculus J774 ID50 316000.0 nM 10.1021/jm2002469
Mus musculus J774 Ratio IC50 58.0 None 10.1016/j.bmcl.2006.02.026
Mus musculus J774.2 CC50 164200.0 nM 10.1016/j.bmc.2021.116417
Mus musculus J774.A1 CC50 201100.0 nM 10.1016/j.ejmech.2019.02.028
Mus musculus L929 Activity 42.0 % 10.1016/j.ejmech.2014.12.051
Mus musculus L929 IC50 256000.0 nM 10.1016/j.ejmech.2017.04.075
Mus musculus Mus musculus Activity 0.0 % 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 3.0 % 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 6.0 % 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 13.2 g/L 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 13.5 g/L 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 32.5 IU/L 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 39.3 % 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 42.4 % 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 49.0 IU/L 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 100.0 % 10.1016/j.bmcl.2005.12.087
Mus musculus Mus musculus Activity 162.0 IU/L 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 177.0 IU/L 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 5100.0 /uL 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity 6700.0 /uL 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2007.12.016
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2009.04.015
Mus musculus Mus musculus Activity nan None 10.1128/aac.00332-10
Mus musculus Mus musculus IC50 263440.0 nM 10.1016/j.bmc.2016.11.033
Mus musculus Mus musculus LD50 800.0 mg.kg-1 10.1021/jm00217a017
Mus musculus Mus musculus LD50 1600.0 mg.kg-1 10.1021/jm00217a017
Naegleria gruberi Naegleria gruberi Inhibition 11.1 % 10.6019/CHEMBL4513101
Plasmodium falciparum Plasmodium falciparum IC50 nan nM 10.1016/j.bmcl.2004.05.026
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/jm900946n
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 14.26 % 10.6019/CHEMBL4513149
Rattus norvegicus H9c2 IC50 50000.0 nM 10.1016/j.bmc.2018.06.033
Rattus norvegicus L6 CC50 78200.0 nM 10.1016/j.ejmech.2014.07.103
Rattus norvegicus L6 IC50 32000.0 nM 10.1016/j.ejmech.2015.10.007
Rattus norvegicus L6 IC50 68000.0 nM 10.1021/jm050177+
Rattus norvegicus L6 IC50 100000.0 nM 10.6019/CHEMBL1862790
Rattus norvegicus Rattus norvegicus IC50 32000.0 nM 10.1016/j.bmc.2016.08.036
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity nan None 10.1016/j.ejmech.2013.04.065
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity nan None 10.1016/j.ejmech.2017.04.075
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity nan None 10.1021/jm500018m
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1929 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.8408 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Inhibition 33.42 % 10.6019/CHEMBL4513149
Trichomonas vaginalis Trichomonas vaginalis IC50 nan None 10.1016/j.bmcl.2017.05.071
Trypanosoma brucei Trypanosoma brucei Activity nan None 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei EC50 2400.0 nM 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei EC50 7300.0 nM 10.1021/jm301215e
Trypanosoma brucei Trypanosoma brucei EC50 7500.0 nM 10.1016/j.bmcl.2017.01.043
Trypanosoma brucei Trypanosoma brucei EC50 20100.0 nM 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei EC50 20300.0 nM 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei ED50 36.7 mg.kg-1 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei ED99 128.0 mg kg-1 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei IC50 260.0 nM 10.1016/j.bmcl.2012.09.005
Trypanosoma brucei Trypanosoma brucei IC50 1700.0 nM 10.1016/j.bmcl.2011.12.101
Trypanosoma brucei Trypanosoma brucei IC50 1800.0 nM 10.1128/aac.01213-09
Trypanosoma brucei Trypanosoma brucei IC50 1830.0 nM 10.1016/j.bmcl.2012.09.005
Trypanosoma brucei Trypanosoma brucei IC50 2060.0 nM 10.1128/aac.00800-10
Trypanosoma brucei Trypanosoma brucei IC50 4100.0 nM 10.1021/jm050177+
Trypanosoma brucei Trypanosoma brucei IC50 4300.0 nM 10.1021/jm050177+
Trypanosoma brucei Trypanosoma brucei IC50 7580.0 nM 10.1016/j.bmc.2018.06.033
Trypanosoma brucei Trypanosoma brucei IC50 11400.0 nM 10.1021/jm050177+
Trypanosoma brucei Trypanosoma brucei IC50 nan nM 10.1016/j.bmcl.2004.05.026
Trypanosoma brucei Trypanosoma brucei Inhibition nan % 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei MIC 15.2 ug.mL-1 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei Ratio EC50 8.0 None 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei Ratio IC50 7.0 None 10.1016/j.bmcl.2012.09.005
Trypanosoma brucei Trypanosoma brucei TIME 7.3 hr 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei TIME 12.8 hr 10.1128/aac.00332-10
Trypanosoma brucei brucei Nucleoside transporter 2 P2 uptake nan None 10.1021/jm050177+
Trypanosoma brucei brucei Trypanosoma brucei brucei Activity nan None 10.1016/j.ejmech.2016.12.002
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 57.0 nM 10.1016/j.ejmech.2020.112043
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 600.0 nM 10.1016/j.ejmech.2020.112558
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 600.0 nM 10.1016/j.ejmech.2020.112668
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 600.0 nM 10.1021/acsmedchemlett.9b00566
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1870.0 nM 10.1016/j.ejmech.2020.112558
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1870.0 nM 10.1016/j.ejmech.2020.112668
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1900.0 nM 10.1021/acsmedchemlett.9b00566
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 2600.0 nM 10.1016/j.ejmech.2020.112558
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 2600.0 nM 10.1016/j.ejmech.2020.112668
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 10000.0 nM 10.1016/j.ejmech.2020.112043
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 15000.0 nM 10.1016/j.ejmech.2016.12.002
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 15000.0 nM 10.1039/C9MD00064J
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1.34 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 130.0 nM 10.1016/j.ejmech.2014.09.045
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 130.0 nM 10.1021/jm201215n
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 130.0 nM 10.1021/jm300508n
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 430.0 nM 10.1016/j.bmc.2015.08.014
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 430.0 nM 10.1016/j.ejmech.2015.08.042
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 869.0 nM 10.1016/j.ejmech.2016.04.010
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 869.0 nM 10.1016/j.ejmech.2016.08.002
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1710.0 nM 10.1016/j.ejmech.2014.09.045
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1710.0 nM 10.1021/jm201215n
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1710.0 nM 10.1021/jm300508n
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1870.0 nM 10.1016/j.ejmech.2018.07.064
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2000.0 nM 10.1016/j.ejmech.2020.112802
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2390.0 nM 10.1016/j.ejmech.2019.04.052
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2900.0 nM 10.1016/j.bmcl.2013.09.047
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3400.0 nM 10.1016/j.bmcl.2006.02.026
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3400.0 nM 10.1021/jm900629w
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3980.0 nM 10.1016/j.ejmech.2016.04.010
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3980.0 nM 10.1016/j.ejmech.2016.08.002
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 4410.0 nM 10.1016/j.bmc.2015.08.014
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 4410.0 nM 10.1016/j.ejmech.2015.08.042
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 4700.0 nM 10.1016/j.bmc.2021.116253
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 5600.0 nM 10.1021/jm050177+
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 6000.0 nM 10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 6359.0 nM 10.1016/j.ejmech.2016.04.010
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 6359.0 nM 10.1016/j.ejmech.2016.08.002
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan nM 10.1021/jm050177+
Trypanosoma brucei brucei Trypanosoma brucei brucei MIC 200000.0 nM 10.1016/j.bmcl.2006.02.026
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 7.3 None 10.1016/j.ejmech.2016.04.010
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 10.3 None 10.1016/j.bmc.2015.08.014
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 10.3 None 10.1016/j.ejmech.2015.08.042
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 13.0 None 10.1021/jm201215n
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 13.0 None 10.1021/jm300508n
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 13.2 None 10.1016/j.ejmech.2014.09.045
Trypanosoma brucei gambiense Trypanosoma brucei gambiense EC50 260.0 nM 10.1128/aac.00332-10
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 1.32 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 4400.0 nM 10.1016/j.ejmech.2014.07.103
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 4600.0 nM 10.1016/j.bmc.2021.116253
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 4640.0 nM 10.1016/j.ejmech.2019.04.052
Trypanosoma brucei rhodesiense Rhodesain Inhibition nan % 10.1021/jm900629w
Trypanosoma brucei rhodesiense Rhodesain Ki nan None 10.1016/j.bmcl.2006.02.026
Trypanosoma brucei rhodesiense Rhodesain Ki nan None 10.1021/jm900629w
Trypanosoma brucei rhodesiense Rhodesain Ki nan None 10.1021/jm900946n
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense EC50 1708.0 nM 10.1021/jm301215e
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.3 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.42 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 1.25 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 1440.0 nM 10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 1500.0 nM 10.1021/jm050177+
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2000.0 nM 10.1016/j.bmc.2010.01.068
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 4400.0 nM 10.1016/j.bmc.2021.116253
Trypanosoma congolense Trypanosoma congolense IC50 1100.0 nM 10.1016/j.bmc.2021.116253
Trypanosoma cruzi Trypanosoma cruzi Activity 0.6 ug ml-1 10.1016/j.bmc.2009.09.013
Trypanosoma cruzi Trypanosoma cruzi Activity 40.74 % 10.1016/j.ejmech.2018.07.005
Trypanosoma cruzi Trypanosoma cruzi Activity 50.0 % 10.1016/j.ejmech.2018.07.005
Trypanosoma cruzi Trypanosoma cruzi Activity 50.89 % 10.1016/j.ejmech.2008.07.018
Trypanosoma cruzi Trypanosoma cruzi Activity 51.0 % 10.1016/j.ejmech.2017.03.063
Trypanosoma cruzi Trypanosoma cruzi Activity 52.5 % 10.1016/j.bmcl.2012.07.013
Trypanosoma cruzi Trypanosoma cruzi Activity 52.5 % 10.1039/C3MD00025G
Trypanosoma cruzi Trypanosoma cruzi Activity 66.0 % 10.1016/j.ejmech.2017.03.063
Trypanosoma cruzi Trypanosoma cruzi Activity 66.3 % 10.1016/j.bmc.2007.10.038
Trypanosoma cruzi Trypanosoma cruzi Activity 75.5 % 10.1016/j.bmc.2014.01.036
Trypanosoma cruzi Trypanosoma cruzi Activity 75.5 % 10.1016/j.bmcl.2005.12.087
Trypanosoma cruzi Trypanosoma cruzi Activity 75.5 % 10.1016/j.ejmech.2011.04.057
Trypanosoma cruzi Trypanosoma cruzi Activity 80.0 % 10.1016/j.bmc.2007.07.031
Trypanosoma cruzi Trypanosoma cruzi Activity 80.0 % 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi Activity 87.0 % 10.1016/j.ejmech.2009.06.014
Trypanosoma cruzi Trypanosoma cruzi Activity 87.0 % 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi Activity 88.1 % 10.1016/j.bmcl.2005.12.087
Trypanosoma cruzi Trypanosoma cruzi Activity 88.14 % 10.1016/j.ejmech.2011.04.057
Trypanosoma cruzi Trypanosoma cruzi Activity 90.0 % 10.1016/j.bmc.2014.01.036
Trypanosoma cruzi Trypanosoma cruzi Activity 90.0 % 10.1016/j.bmcl.2005.12.087
Trypanosoma cruzi Trypanosoma cruzi Activity 90.0 % 10.1016/j.ejmech.2009.06.014
Trypanosoma cruzi Trypanosoma cruzi Activity 90.0 % 10.1016/j.ejmech.2011.04.057
Trypanosoma cruzi Trypanosoma cruzi Activity 90.0 % 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi Activity 94.2 % 10.1016/j.ejmech.2015.12.045
Trypanosoma cruzi Trypanosoma cruzi Activity 94.4 % 10.1016/j.bmcl.2005.12.087
Trypanosoma cruzi Trypanosoma cruzi Activity 94.44 % 10.1016/j.ejmech.2011.04.057
Trypanosoma cruzi Trypanosoma cruzi Activity 98.7 % 10.1016/j.bmcl.2005.12.087
Trypanosoma cruzi Trypanosoma cruzi Activity 98.7 % 10.1016/j.ejmech.2011.04.057
Trypanosoma cruzi Trypanosoma cruzi Activity 98.73 % 10.1016/j.bmc.2014.01.036
Trypanosoma cruzi Trypanosoma cruzi Activity 100.0 % 10.1016/j.bmcl.2005.12.087
Trypanosoma cruzi Trypanosoma cruzi Activity 100.0 % 10.1016/j.ejmech.2011.04.057
Trypanosoma cruzi Trypanosoma cruzi Activity 100.0 % 10.1039/C3MD00025G
Trypanosoma cruzi Trypanosoma cruzi Activity 113.0 % 10.1016/j.bmc.2007.10.038
Trypanosoma cruzi Trypanosoma cruzi Activity 117.0 % 10.1016/j.bmc.2007.07.031
Trypanosoma cruzi Trypanosoma cruzi Activity 120.4 % 10.1016/j.bmc.2007.10.038
Trypanosoma cruzi Trypanosoma cruzi Activity nan None 10.1016/j.ejmech.2007.12.016
Trypanosoma cruzi Trypanosoma cruzi Activity nan None 10.1016/j.ejmech.2009.06.014
Trypanosoma cruzi Trypanosoma cruzi Activity nan None 10.1016/j.ejmech.2020.112849
Trypanosoma cruzi Trypanosoma cruzi CC50 2700.0 nM 10.1016/j.ejmech.2014.02.001
Trypanosoma cruzi Trypanosoma cruzi CC50 2700.0 nM 10.1016/j.ejmech.2015.06.048
Trypanosoma cruzi Trypanosoma cruzi EC50 700.0 nM 10.1128/aac.01777-09
Trypanosoma cruzi Trypanosoma cruzi EC50 900.0 nM 10.1016/j.bmcl.2018.04.064
Trypanosoma cruzi Trypanosoma cruzi EC50 900.0 nM 10.1016/j.ejmech.2018.02.020
Trypanosoma cruzi Trypanosoma cruzi EC50 1200.0 nM 10.1128/aac.01777-09
Trypanosoma cruzi Trypanosoma cruzi EC50 1258.93 nM 10.1021/acs.jmedchem.7b00463
Trypanosoma cruzi Trypanosoma cruzi EC50 1260.0 nM 10.1016/j.ejmech.2015.12.045
Trypanosoma cruzi Trypanosoma cruzi EC50 1500.0 nM 10.1021/acs.jnatprod.8b00159
Trypanosoma cruzi Trypanosoma cruzi EC50 2100.0 nM 10.1128/aac.01777-09
Trypanosoma cruzi Trypanosoma cruzi EC50 2200.0 nM 10.1016/j.ejmech.2016.12.017
Trypanosoma cruzi Trypanosoma cruzi EC50 8000.0 nM 10.1016/j.bmcl.2020.127052
Trypanosoma cruzi Trypanosoma cruzi ED50 0.4 uM 10.1016/s0960-894x(02)00788-6
Trypanosoma cruzi Trypanosoma cruzi Emax 96.6 % 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi GI 46.0 % 10.1016/j.ejmech.2009.04.015
Trypanosoma cruzi Trypanosoma cruzi GI 49.9 % 10.1016/j.bmcl.2014.06.044
Trypanosoma cruzi Trypanosoma cruzi GI 82.2 % 10.1016/j.ejmech.2017.04.075
Trypanosoma cruzi Trypanosoma cruzi GI 91.57 % 10.1016/j.ejmech.2012.10.009
Trypanosoma cruzi Trypanosoma cruzi GI 93.0 % 10.1021/jm0600343
Trypanosoma cruzi Trypanosoma cruzi GI 96.54 % 10.1016/j.bmcl.2013.12.071
Trypanosoma cruzi Trypanosoma cruzi GI 97.07 % 10.1016/j.ejmech.2012.10.009
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1007/s00044-013-0781-3
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/0960-894X(95)00248-R
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.bmc.2007.11.077
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.bmc.2008.05.038
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.bmc.2011.09.037
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.bmcl.2010.06.101
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.bmcl.2013.12.071
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.ejmech.2007.06.020
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.ejmech.2008.07.018
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.ejmech.2009.12.061
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.ejmech.2012.10.009
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.ejmech.2013.04.065
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1016/j.ejmech.2017.04.075
Trypanosoma cruzi Trypanosoma cruzi GI 100.0 % 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi GI50 3780.0 nM 10.1016/j.ejmech.2013.03.053
Trypanosoma cruzi Trypanosoma cruzi IC50 3.0 ug.mL-1 10.1021/jm100265s
Trypanosoma cruzi Trypanosoma cruzi IC50 3.0 ug.mL-1 10.1021/np800472q
Trypanosoma cruzi Trypanosoma cruzi IC50 230.0 nM 10.6019/CHEMBL1862790
Trypanosoma cruzi Trypanosoma cruzi IC50 240.0 nM 10.1128/aac.00800-10
Trypanosoma cruzi Trypanosoma cruzi IC50 300.0 nM 10.1021/acsmedchemlett.8b00347
Trypanosoma cruzi Trypanosoma cruzi IC50 390.0 nM 10.1016/s0960-894x(03)00326-3
Trypanosoma cruzi Trypanosoma cruzi IC50 390.0 nM 10.1021/np040059+
Trypanosoma cruzi Trypanosoma cruzi IC50 400.0 nM 10.1016/j.bmc.2018.06.033
Trypanosoma cruzi Trypanosoma cruzi IC50 450.0 nM 10.1016/j.bmcl.2004.05.026
Trypanosoma cruzi Trypanosoma cruzi IC50 450.0 nM 10.1021/jm500018m
Trypanosoma cruzi Trypanosoma cruzi IC50 500.0 nM 10.1016/j.bmcl.2013.12.071
Trypanosoma cruzi Trypanosoma cruzi IC50 500.0 nM 10.1016/j.ejmech.2017.04.075
Trypanosoma cruzi Trypanosoma cruzi IC50 520.0 nM 10.1021/jm800812k
Trypanosoma cruzi Trypanosoma cruzi IC50 700.0 nM 10.1016/j.bmc.2014.08.005
Trypanosoma cruzi Trypanosoma cruzi IC50 700.0 nM 10.1016/j.ejmech.2017.11.075
Trypanosoma cruzi Trypanosoma cruzi IC50 900.0 nM 10.1016/j.ejmech.2018.03.048
Trypanosoma cruzi Trypanosoma cruzi IC50 1400.0 nM 10.1016/j.bmcl.2008.05.013
Trypanosoma cruzi Trypanosoma cruzi IC50 1400.0 nM 10.1021/acs.jmedchem.0c01372
Trypanosoma cruzi Trypanosoma cruzi IC50 1500.0 nM 10.1021/jm050177+
Trypanosoma cruzi Trypanosoma cruzi IC50 1600.0 nM 10.1016/j.ejmech.2014.08.055
Trypanosoma cruzi Trypanosoma cruzi IC50 1800.0 nM 10.1016/j.bmcl.2013.02.054
Trypanosoma cruzi Trypanosoma cruzi IC50 1900.0 nM 10.1007/s00044-012-0010-5
Trypanosoma cruzi Trypanosoma cruzi IC50 1900.0 nM 10.1016/j.bmc.2009.05.071
Trypanosoma cruzi Trypanosoma cruzi IC50 1900.0 nM 10.1021/jm301518v
Trypanosoma cruzi Trypanosoma cruzi IC50 2100.0 nM 10.1016/j.bmcl.2011.12.101
Trypanosoma cruzi Trypanosoma cruzi IC50 2100.0 nM 10.1016/j.ejmech.2020.112849
Trypanosoma cruzi Trypanosoma cruzi IC50 2200.0 nM 10.1021/acs.jmedchem.6b00698
Trypanosoma cruzi Trypanosoma cruzi IC50 2300.0 nM 10.1016/j.bmc.2010.05.018
Trypanosoma cruzi Trypanosoma cruzi IC50 2330.0 nM 10.1016/j.bmc.2010.05.018
Trypanosoma cruzi Trypanosoma cruzi IC50 2400.0 nM 10.1021/jm500018m
Trypanosoma cruzi Trypanosoma cruzi IC50 2700.0 nM 10.1021/jm301518v
Trypanosoma cruzi Trypanosoma cruzi IC50 2800.0 nM 10.1128/aac.00313-10
Trypanosoma cruzi Trypanosoma cruzi IC50 2970.0 nM 10.1016/j.bmc.2018.06.033
Trypanosoma cruzi Trypanosoma cruzi IC50 3000.0 nM 10.1021/acsmedchemlett.8b00247
Trypanosoma cruzi Trypanosoma cruzi IC50 3290.0 nM 10.1016/0960-894X(95)00248-R
Trypanosoma cruzi Trypanosoma cruzi IC50 3400.0 nM 10.1016/j.bmc.2009.10.030
Trypanosoma cruzi Trypanosoma cruzi IC50 3400.0 nM 10.1016/j.ejmech.2008.07.018
Trypanosoma cruzi Trypanosoma cruzi IC50 3550.0 nM 10.1016/0960-894X(95)00248-R
Trypanosoma cruzi Trypanosoma cruzi IC50 3590.0 nM 10.1016/j.bmc.2013.06.017
Trypanosoma cruzi Trypanosoma cruzi IC50 3600.0 nM 10.1016/j.bmcl.2017.06.013
Trypanosoma cruzi Trypanosoma cruzi IC50 3600.0 nM 10.1016/j.ejmech.2017.04.075
Trypanosoma cruzi Trypanosoma cruzi IC50 3610.0 nM 10.1016/j.bmcl.2013.12.071
Trypanosoma cruzi Trypanosoma cruzi IC50 3610.0 nM 10.1016/j.ejmech.2012.10.009
Trypanosoma cruzi Trypanosoma cruzi IC50 3810.0 nM 10.1016/0960-894X(95)00248-R
Trypanosoma cruzi Trypanosoma cruzi IC50 4000.0 nM 10.1016/j.ejmech.2014.08.055
Trypanosoma cruzi Trypanosoma cruzi IC50 4000.0 nM 10.1016/j.ejmech.2016.10.055
Trypanosoma cruzi Trypanosoma cruzi IC50 4500.0 nM 10.1016/j.bmc.2010.03.018
Trypanosoma cruzi Trypanosoma cruzi IC50 4800.0 nM 10.1016/j.bmcl.2008.05.013
Trypanosoma cruzi Trypanosoma cruzi IC50 5180.0 nM 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi IC50 5700.0 nM 10.1016/j.ejmech.2014.02.001
Trypanosoma cruzi Trypanosoma cruzi IC50 5700.0 nM 10.1016/j.ejmech.2015.06.048
Trypanosoma cruzi Trypanosoma cruzi IC50 5900.0 nM 10.1016/j.bmc.2018.06.033
Trypanosoma cruzi Trypanosoma cruzi IC50 6000.0 nM 10.1021/jm9004835
Trypanosoma cruzi Trypanosoma cruzi IC50 6000.0 nM 10.1021/np070081d
Trypanosoma cruzi Trypanosoma cruzi IC50 6020.0 nM 10.1016/j.ejmech.2015.03.066
Trypanosoma cruzi Trypanosoma cruzi IC50 6020.0 nM 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi IC50 6100.0 nM 10.1016/j.ejmech.2011.03.046
Trypanosoma cruzi Trypanosoma cruzi IC50 6500.0 nM 10.1016/j.bmc.2007.01.009
Trypanosoma cruzi Trypanosoma cruzi IC50 6500.0 nM 10.1016/j.bmc.2007.07.031
Trypanosoma cruzi Trypanosoma cruzi IC50 6500.0 nM 10.1016/j.ejmech.2007.10.031
Trypanosoma cruzi Trypanosoma cruzi IC50 6500.0 nM 10.1021/jm0600343
Trypanosoma cruzi Trypanosoma cruzi IC50 6500.0 nM 10.1021/jm070604e
Trypanosoma cruzi Trypanosoma cruzi IC50 7000.0 nM 10.1016/j.bmcl.2014.06.044
Trypanosoma cruzi Trypanosoma cruzi IC50 7000.0 nM 10.1021/acsmedchemlett.8b00247
Trypanosoma cruzi Trypanosoma cruzi IC50 7090.0 nM 10.1016/j.bmc.2021.116417
Trypanosoma cruzi Trypanosoma cruzi IC50 7320.0 nM 10.1016/j.ejmech.2015.03.066
Trypanosoma cruzi Trypanosoma cruzi IC50 7320.0 nM 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi IC50 7450.0 nM 10.1016/j.bmcl.2017.05.071
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmc.2007.01.009
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmc.2007.11.077
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmc.2008.05.038
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmc.2008.11.065
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmc.2009.01.011
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmc.2011.09.037
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmcl.2010.06.101
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.bmcl.2015.12.070
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.ejmech.2007.10.031
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.ejmech.2009.09.009
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.ejmech.2009.12.061
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.ejmech.2012.10.047
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.ejmech.2013.04.065
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1016/j.ejmech.2017.04.075
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1021/jm0600343
Trypanosoma cruzi Trypanosoma cruzi IC50 7700.0 nM 10.1021/jm070604e
Trypanosoma cruzi Trypanosoma cruzi IC50 8000.0 nM 10.1021/acsmedchemlett.8b00247
Trypanosoma cruzi Trypanosoma cruzi IC50 8000.0 nM 10.1021/jm500018m
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1007/s00044-012-0010-5
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1016/j.bmc.2007.01.009
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1016/j.bmc.2008.05.038
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1016/j.bmc.2009.05.071
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1016/j.ejmech.2007.10.031
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1016/j.ejmech.2009.09.009
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1021/jm0600343
Trypanosoma cruzi Trypanosoma cruzi IC50 8500.0 nM 10.1021/jm070604e
Trypanosoma cruzi Trypanosoma cruzi IC50 8600.0 nM 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi IC50 8700.0 nM 10.1016/j.ejmech.2019.02.028
Trypanosoma cruzi Trypanosoma cruzi IC50 9500.0 nM 10.1016/j.bmc.2007.10.038
Trypanosoma cruzi Trypanosoma cruzi IC50 9930.0 nM 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi IC50 10000.0 nM 10.1016/j.bmc.2016.11.033
Trypanosoma cruzi Trypanosoma cruzi IC50 10000.0 nM 10.1021/np800110e
Trypanosoma cruzi Trypanosoma cruzi IC50 10400.0 nM 10.1016/j.ejmech.2012.10.047
Trypanosoma cruzi Trypanosoma cruzi IC50 10670.0 nM 10.1016/j.bmc.2016.06.031
Trypanosoma cruzi Trypanosoma cruzi IC50 11000.0 nM 10.1021/np030010o
Trypanosoma cruzi Trypanosoma cruzi IC50 11000.0 nM 10.1021/np049890c
Trypanosoma cruzi Trypanosoma cruzi IC50 11000.0 nM 10.1021/np060007f
Trypanosoma cruzi Trypanosoma cruzi IC50 12840.0 nM 10.1016/j.ejmech.2015.03.066
Trypanosoma cruzi Trypanosoma cruzi IC50 12840.0 nM 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi IC50 13500.0 nM 10.1021/np8003529
Trypanosoma cruzi Trypanosoma cruzi IC50 13500.0 nM 10.1021/np900622m
Trypanosoma cruzi Trypanosoma cruzi IC50 17400.0 nM 10.1016/j.bmc.2016.11.033
Trypanosoma cruzi Trypanosoma cruzi IC50 19300.0 nM 10.1016/j.bmc.2021.116417
Trypanosoma cruzi Trypanosoma cruzi IC50 21050.0 nM 10.1016/j.bmc.2014.07.030
Trypanosoma cruzi Trypanosoma cruzi IC50 50750.0 nM 10.1016/j.bmcl.2015.08.018
Trypanosoma cruzi Trypanosoma cruzi IC50 89804.0 nM 10.1016/j.bmcl.2015.08.018
Trypanosoma cruzi Trypanosoma cruzi IC50 167070.0 nM 10.1016/j.bmc.2021.116417
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1021/np030010o
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1021/np049890c
Trypanosoma cruzi Trypanosoma cruzi IC90 25.0 ug 10.1021/np50074a015
Trypanosoma cruzi Trypanosoma cruzi IC90 25.0 ug.mL-1 10.1021/np50099a013
Trypanosoma cruzi Trypanosoma cruzi IC90 50.0 ug 10.1021/np50074a015
Trypanosoma cruzi Trypanosoma cruzi IC90 100.0 ug 10.1021/np50074a015
Trypanosoma cruzi Trypanosoma cruzi IC90 820.0 nM 10.6019/CHEMBL1862790
Trypanosoma cruzi Trypanosoma cruzi IC90 4600.0 nM 10.1016/j.ejmech.2020.112849
Trypanosoma cruzi Trypanosoma cruzi IC90 9060.0 nM 10.1016/j.bmc.2010.05.018
Trypanosoma cruzi Trypanosoma cruzi IC90 11000.0 nM 10.1016/j.bmcl.2008.05.013
Trypanosoma cruzi Trypanosoma cruzi IC90 17000.0 nM 10.1016/j.bmcl.2008.05.013
Trypanosoma cruzi Trypanosoma cruzi IC90 23410.0 nM 10.1016/j.bmc.2010.05.018
Trypanosoma cruzi Trypanosoma cruzi ID50 3.4 mM 10.1016/j.ejmech.2009.06.014
Trypanosoma cruzi Trypanosoma cruzi ID50 3.4 uM 10.1016/j.bmcl.2004.04.088
Trypanosoma cruzi Trypanosoma cruzi ID50 3.4 uM 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi ID50 4.9 mM 10.1016/j.ejmech.2009.06.014
Trypanosoma cruzi Trypanosoma cruzi ID50 4.9 uM 10.1016/j.bmc.2008.07.077
Trypanosoma cruzi Trypanosoma cruzi ID50 4.9 uM 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi ID50 7.7 uM 10.1016/j.bmc.2008.07.077
Trypanosoma cruzi Trypanosoma cruzi ID50 7.7 uM 10.1016/j.bmcl.2004.04.088
Trypanosoma cruzi Trypanosoma cruzi ID50 7.7 uM 10.1016/j.ejmech.2007.06.020
Trypanosoma cruzi Trypanosoma cruzi ID50 7.7 uM 10.1016/j.ejmech.2009.06.014
Trypanosoma cruzi Trypanosoma cruzi ID50 7.7 uM 10.1039/C1MD00223F
Trypanosoma cruzi Trypanosoma cruzi ID50 9.7 mM 10.1016/j.ejmech.2009.06.014
Trypanosoma cruzi Trypanosoma cruzi ID50 9.7 uM 10.1016/j.bmc.2008.07.077
Trypanosoma cruzi Trypanosoma cruzi ID50 9.7 uM 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi ID50 7700.0 uM 10.1021/jm2002469
Trypanosoma cruzi Trypanosoma cruzi Imax 103.0 % 10.1016/j.ejmech.2018.02.020
Trypanosoma cruzi Trypanosoma cruzi Inhibition 7.3 % 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi Inhibition 13.24 % 10.1016/j.bmcl.2005.01.002
Trypanosoma cruzi Trypanosoma cruzi Inhibition 17.39 % 10.1016/j.bmcl.2005.01.002
Trypanosoma cruzi Trypanosoma cruzi Inhibition 19.64 % 10.1016/j.bmcl.2005.01.002
Trypanosoma cruzi Trypanosoma cruzi Inhibition 20.0 % 10.1016/j.bmcl.2005.01.002
Trypanosoma cruzi Trypanosoma cruzi Inhibition 42.62 % 10.1016/j.bmc.2014.07.030
Trypanosoma cruzi Trypanosoma cruzi Inhibition 57.0 % 10.1021/jm00216a001
Trypanosoma cruzi Trypanosoma cruzi Inhibition 92.0 % 10.1021/jm00216a001
Trypanosoma cruzi Trypanosoma cruzi Inhibition 99.0 % 10.1021/jm00216a001
Trypanosoma cruzi Trypanosoma cruzi Inhibition 100.0 % 10.1016/j.bmcl.2005.01.002
Trypanosoma cruzi Trypanosoma cruzi Inhibition 100.0 % 10.1016/j.bmcl.2015.12.070
Trypanosoma cruzi Trypanosoma cruzi Inhibition 100.0 % 10.1021/jm9805790
Trypanosoma cruzi Trypanosoma cruzi Inhibition 100.0 % 10.1039/C2MD20089A
Trypanosoma cruzi Trypanosoma cruzi LC50 1.2 ug.mL-1 10.1016/j.ejmech.2014.09.027
Trypanosoma cruzi Trypanosoma cruzi LC50 8.5 ug.mL-1 10.1016/j.ejmech.2014.09.027
Trypanosoma cruzi Trypanosoma cruzi LC50 33.1 ug.mL-1 10.1016/j.ejmech.2017.03.063
Trypanosoma cruzi Trypanosoma cruzi LC50 46.7 ug.mL-1 10.1016/j.ejmech.2017.03.063
Trypanosoma cruzi Trypanosoma cruzi LC50 77230.0 nM 10.1016/j.ejmech.2018.07.005
Trypanosoma cruzi Trypanosoma cruzi LC50 89520.0 nM 10.1016/j.ejmech.2018.07.005
Trypanosoma cruzi Trypanosoma cruzi LC50 310000.0 nM 10.1016/j.ejmech.2015.04.028
Trypanosoma cruzi Trypanosoma cruzi LC50 600000.0 nM 10.1016/j.ejmech.2015.04.028
Trypanosoma cruzi Trypanosoma cruzi log1/GI50 5.42 None 10.1016/j.ejmech.2013.03.053
Trypanosoma cruzi Trypanosoma cruzi log1/IC50 4.89 None 10.1016/j.ejmech.2015.03.066
Trypanosoma cruzi Trypanosoma cruzi log1/IC50 4.89 None 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi log1/IC50 5.0 None 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi log1/IC50 5.14 None 10.1016/j.ejmech.2015.03.066
Trypanosoma cruzi Trypanosoma cruzi log1/IC50 5.14 None 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi log1/IC50 5.22 None 10.1016/j.ejmech.2015.03.066
Trypanosoma cruzi Trypanosoma cruzi log1/IC50 5.22 None 10.1016/j.ejmech.2017.12.011
Trypanosoma cruzi Trypanosoma cruzi %max 99.0 % 10.1016/j.ejmech.2020.112849
Trypanosoma cruzi Trypanosoma cruzi MIC 5000.0 nM 10.1016/j.ejmech.2018.02.020
Trypanosoma cruzi Trypanosoma cruzi MIC 7700.0 nM 10.1007/s00044-013-0781-3
Trypanosoma cruzi Trypanosoma cruzi MST 0.0 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 2.5 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 3.0 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 4.0 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 5.5 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 6.5 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 8.0 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 40.0 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi MST 60.0 day 10.1021/jm00217a017
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 6.75 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 7.0 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 12.5 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 13.5 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 14.0 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 16.25 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 20.0 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Myoblasts with parasites 34.5 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 9.25 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 20.25 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 27.0 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 34.75 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 64.5 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 70.5 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 80.25 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 155.0 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi R 321.0 % 10.1021/jm970860z
Trypanosoma cruzi Trypanosoma cruzi Ratio 1.0 None 10.1021/jm00216a001
Trypanosoma cruzi Trypanosoma cruzi Ratio IC50 1.5 None 10.1016/j.ejmech.2012.10.047
Trypanosoma cruzi Trypanosoma cruzi Ratio IC50 2.0 None 10.1016/j.ejmech.2015.03.066
Trypanosoma cruzi Trypanosoma cruzi Ratio IC50 11.4 None 10.1016/j.ejmech.2012.10.047
Trypanosoma cruzi Trypanosoma cruzi SD90 4.15 mg kg-1 10.1021/jm00216a001
Trypanosoma cruzi Trypanosoma cruzi TIME 24.0 hr 10.1021/acs.jmedchem.7b00463
Trypanosoma cruzi Trypanothione reductase Ki 245000.0 nM 10.1016/j.ejmech.2016.10.055
Trypanosoma evansi Trypanosoma evansi IC50 0.75 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma evansi Trypanosoma evansi IC50 2600.0 nM 10.1016/j.bmc.2021.116253
None ADMET Activity 1.0 ug ml-1 10.1016/j.bmc.2009.05.071
None ADMET Activity 1.0 ug ml-1 10.1021/jm301518v
None ADMET Activity nan None 10.1021/acs.jmedchem.6b00784
None ADMET delta logD 0.0 None 10.1021/jm0000564
None ADMET Drug metabolism 74.0 nmol/min/mg 10.1016/j.bmc.2013.08.022
None ADMET EC50 10000.0 nM 10.1128/aac.01777-09
None ADMET F 79.0 % 10.1021/jm0000564
None ADMET IC50 17000.0 nM 10.1128/aac.00800-10
None ADMET IC50 146000.0 nM 10.1128/aac.00800-10
None ADMET IC50 200000.0 nM 10.1016/j.bmc.2013.06.017
None ADMET IC50 200000.0 nM 10.1016/j.ejmech.2013.03.053
None ADMET IC50 200000.0 nM 10.1016/j.ejmech.2015.03.066
None ADMET ID50 100.0 uM 10.1039/C0MD00085J
None ADMET ID50 100.0 uM 10.1039/C1MD00223F
None ADMET Inhibition 26.83 % 10.1016/j.bmcl.2013.12.071
None ADMET LC50 256000.0 nM 10.1016/j.bmcl.2013.12.071
None ADMET MNCC 3.4 uM 10.1007/s00044-012-0010-5
None ADMET MNCC 3.4 uM 10.1016/j.ejmech.2014.02.001
None ADMET MNTD 3.5 uM 10.1016/j.ejmech.2015.06.048
None ADMET Peff nan None 10.1016/j.bmc.2016.08.036
None ADMET Peff nan None 10.1016/j.ejmech.2015.10.007
None ADMET Ratio CC50/IC50 8.51 None 10.1016/j.bmc.2021.116417
None ADMET Ratio CC50/IC50 23.13 None 10.1016/j.bmc.2021.116417
None ADMET Ratio IC50 36.0 None 10.1128/aac.01213-09
None ADMET TI 38.0 None 10.1016/j.ejmech.2007.06.020
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None NON-PROTEIN TARGET CC50 26800.0 nM 10.1016/j.ejmech.2016.04.065
None NON-PROTEIN TARGET EC50 340.0 nM 10.1016/j.ejmech.2016.04.065
None NON-PROTEIN TARGET EC50 2800.0 nM 10.1016/j.bmcl.2016.09.051
None NON-PROTEIN TARGET EC50 100000.0 nM 10.1016/j.bmcl.2016.09.051
None NON-PROTEIN TARGET Emax 101.5 % 10.1016/j.ejmech.2016.04.065
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 63000.0 nM 10.1016/j.bmcl.2016.09.051
None NON-PROTEIN TARGET Ratio IC50 15.14 None 10.1016/j.bmc.2016.11.033
None NON-PROTEIN TARGET Ratio IC50 26.34 None 10.1016/j.bmc.2016.11.033
None No relevant target Activity -0.61 V 10.1016/j.ejmech.2020.112668
None No relevant target LogD 0.08 None 10.1021/jm0000564
None No relevant target LogP -0.746 None 10.1016/j.bmcl.2010.06.101
None No relevant target pKa nan None 10.1021/jm0000564
None Unchecked Activity 423.0 nmol/min/mg 10.1016/j.bmcl.2012.09.005
None Unchecked Activity nan None 10.1016/j.ejmech.2009.06.014
None Unchecked Activity nan None 10.1021/jm300508n
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 600.0 nM 10.1016/j.ejmech.2018.07.064
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2020.112849
None Unchecked IC50 64000.0 nM 10.1016/j.ejmech.2017.11.075
None Unchecked IC50 65090.0 nM 10.1016/j.ejmech.2019.04.052
None Unchecked IC50 127000.0 nM 10.1016/j.ejmech.2020.112849
None Unchecked Inhibition nan % 10.1021/jm2002469
None Unchecked Kcat/Km 3.4 /M/s 10.1128/aac.01213-09
None Unchecked Ki nan None 10.1021/jm900946n
None Unchecked Km 53100.0 nM 10.1128/aac.01213-09
None Unchecked Ratio 33.3 None 10.1016/j.ejmech.2010.01.052
None Unchecked Ratio 44.9 None 10.1016/j.ejmech.2009.06.014
None Unchecked Ratio CC50/EC50 17.4 None 10.1016/j.ejmech.2020.112668
None Unchecked Ratio CC50/EC50 76.5 None 10.1016/j.ejmech.2015.12.045
None Unchecked Ratio CC50/EC50 78.9 None 10.1016/j.ejmech.2016.04.065
None Unchecked Ratio CC50/IC50 16.45 None 10.1016/j.ejmech.2017.12.011
None Unchecked Ratio CC50/IC50 17.8 None 10.1016/j.ejmech.2014.07.103
None Unchecked Ratio CC50/IC50 23.1 None 10.1016/j.ejmech.2019.02.028
None Unchecked Ratio CC50/IC50 23.7 None 10.1016/j.bmcl.2008.05.013
None Unchecked Ratio CC50/IC50 36.5 None 10.1016/j.bmcl.2017.06.013
None Unchecked Ratio CC50/IC50 81.1 None 10.1016/j.bmcl.2008.05.013
None Unchecked Ratio CC50/IC50 nan None 10.1016/j.ejmech.2019.02.028
None Unchecked Ratio EC50 3.0 None 10.1021/jm301215e
None Unchecked Ratio EC50 5.0 None 10.1016/j.ejmech.2020.112043
None Unchecked Ratio EC50 10.0 None 10.1016/j.ejmech.2016.12.002
None Unchecked Ratio EC50 10.0 None 10.1016/j.ejmech.2020.112043
None Unchecked Ratio EC50 10.0 None 10.1039/C9MD00064J
None Unchecked Ratio EC50 38.0 None 10.1021/jm301215e
None Unchecked Ratio IC50 1.5 None 10.1016/j.bmc.2009.01.011
None Unchecked Ratio IC50 7.3 None 10.1016/j.bmc.2016.08.036
None Unchecked Ratio IC50 7.3 None 10.1016/j.ejmech.2015.10.007
None Unchecked Ratio IC50 7.3 None 10.1016/j.ejmech.2016.08.002
None Unchecked Ratio IC50 7.7 None 10.1016/j.ejmech.2012.10.047
None Unchecked Ratio IC50 14.0 None 10.1016/j.ejmech.2019.04.052
None Unchecked Ratio IC50 14.0 None 10.1021/acsmedchemlett.8b00247
None Unchecked Ratio IC50 16.0 None 10.1016/j.ejmech.2015.03.066
None Unchecked Ratio IC50 16.0 None 10.1021/acsmedchemlett.8b00247
None Unchecked Ratio IC50 17.0 None 10.1021/acsmedchemlett.1c00193
None Unchecked Ratio IC50 20.8 None 10.1016/j.bmc.2010.03.018
None Unchecked Ratio IC50 27.0 None 10.1016/j.ejmech.2012.10.047
None Unchecked Ratio IC50 27.0 None 10.1016/j.ejmech.2015.03.066
None Unchecked Ratio IC50 33.0 None 10.1016/j.ejmech.2015.03.066
None Unchecked Ratio IC50 38.0 None 10.1021/acsmedchemlett.8b00247
None Unchecked Ratio IC50 40.0 None 10.1016/j.bmcl.2014.06.044
None Unchecked Ratio IC50 41.0 None 10.1016/j.ejmech.2013.04.065
None Unchecked Ratio IC50 41.0 None 10.1016/j.ejmech.2017.04.075
None Unchecked Ratio IC50 53.0 None 10.1016/j.bmc.2013.06.017
None Unchecked Ratio IC50 60.0 None 10.1016/j.ejmech.2020.112849
None Unchecked Ratio IC50 71.1 None 10.1016/j.ejmech.2017.04.075
None Unchecked Ratio IC50 74.2 None 10.1016/j.bmc.2013.06.017
None Unchecked Ratio IC50 150.0 None 10.1021/jm500018m
None Unchecked Ratio IC50 154.0 None 10.1021/jm800812k
None Unchecked Ratio IC50 200.0 None 10.1021/jm500018m
None Unchecked Ratio LC50/IC50 70.91 None 10.1016/j.bmcl.2013.12.071
None Unchecked Ratio LC50/IC50 512.0 None 10.1016/j.bmcl.2013.12.071
None Unchecked Selectivity Index 13.0 None 10.1039/C0MD00085J
None Unchecked Selectivity Index 13.0 None 10.1039/C1MD00223F
None Unchecked Selectivity Index 17.0 None 10.1016/j.ejmech.2014.08.055
None Unchecked Selectivity Index 17.4 None 10.1016/j.ejmech.2020.112558
None Unchecked Selectivity Index 20.0 None 10.1016/j.bmc.2014.07.030
None Unchecked Selectivity Index 26.36 None 10.1016/j.bmc.2010.05.018
None Unchecked Selectivity Index 26.7 None 10.1016/j.bmc.2010.05.018
None Unchecked Selectivity Index 41.0 None 10.1016/j.bmc.2009.09.013
None Unchecked Selectivity Index 41.0 None 10.1021/jm2002469
None Unchecked Selectivity Index 43.0 None 10.1016/j.ejmech.2014.08.055
None Unchecked Selectivity Index 52.91 None 10.1016/j.ejmech.2013.03.053
None Unchecked Selectivity Index 68.0 None 10.1016/j.ejmech.2016.10.055
None Unchecked Vmax 423.3 nmol/min 10.1128/aac.01213-09

Metabolism Information