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name Structure Reference Source Properties Activities Metabolism

(-)-rolipram

AlkaPlorer ID: AK323903

Synonym: None

IUPAC Name: 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

Structure

SMILES: COC1=CC=C(C2CNC(=O)C2)C=C1OC1CCCC1

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InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

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InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N

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Reference

PubChem CID: 5092

CAS: 61413-54-5

NPASS: NPC485458

COCONUT: CNP0340647.2

Properties Information

Molecule Weight: 275.348

TPSA？: 47.56

MolLogP？: 2.6201000000000008

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 23.36 % 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii MIC 20000.0 nM 10.6019/CHEMBL4513161
Bos taurus Phosphodiesterase 1 IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
Bos taurus Phosphodiesterase 1 IC50 2700000.0 nM 10.1021/jm00127a009
Bos taurus Phosphodiesterase 5A IC50 10000.0 nM 10.1016/j.bmcl.2012.04.094
Bos taurus Phosphodiesterase 5A IC50 10000.0 nM 10.1021/jm950197j
Bos taurus Phosphodiesterase 5A IC50 246000.0 nM 10.1021/jm00127a009
Candida albicans Candida albicans Inhibition 4.38 % 10.6019/CHEMBL4513141
Candida albicans Candida albicans MIC 20000.0 nM 10.6019/CHEMBL4513161
Canis lupus familiaris Canis familiaris Activity nan None 10.1016/s0960-894x(99)00573-9
Canis lupus familiaris Canis familiaris DOSE 0.003 mg.kg-1 10.1016/s0960-894x(00)00548-5
Canis lupus familiaris Canis familiaris ED50 0.03 mg.kg-1 10.1016/s0960-894x(98)00572-1
Canis lupus familiaris Canis familiaris ED50 0.3 umol.kg-1 10.1016/s0960-894x(00)00449-2
Canis lupus familiaris Canis familiaris Ratio 1.0 None 10.1021/jm970575f
Canis lupus familiaris Canis familiaris Ratio 2.0 None 10.1021/jm970575f
Cavia porcellus Cavia porcellus Activity 13.0 nM 10.1016/j.bmcl.2014.04.052
Cavia porcellus Cavia porcellus Activity 50.0 % 10.1016/j.bmcl.2014.04.052
Cavia porcellus Cavia porcellus Activity nan None 10.1016/j.bmc.2013.07.007
Cavia porcellus Cavia porcellus Duration 15.0 min 10.1021/jm00037a021
Cavia porcellus Cavia porcellus Duration 29.0 min 10.1021/jm00037a021
Cavia porcellus Cavia porcellus Duration 38.0 min 10.1021/jm00037a021
Cavia porcellus Cavia porcellus ED50 0.004 mg.kg-1 10.1016/s0960-894x(00)00548-5
Cavia porcellus Cavia porcellus ED50 0.01 mg.kg-1 10.1021/jm9509096
Cavia porcellus Cavia porcellus ED50 0.6 mg.kg-1 10.1021/jm9505066
Cavia porcellus Cavia porcellus ED50 0.6 mg.kg-1 10.1021/jm9800090
Cavia porcellus Cavia porcellus ED50 19.0 mg.kg-1 10.1021/jm9509096
Cavia porcellus Cavia porcellus Heart rate 3.0 beats min-1 10.1021/jm9509096
Cavia porcellus Cavia porcellus Heart rate 9.0 beats min-1 10.1021/jm9509096
Cavia porcellus Cavia porcellus IC50 160.0 nM 10.1021/jm00037a021
Cavia porcellus Cavia porcellus IC50 340.0 nM 10.1021/jm00104a013
Cavia porcellus Cavia porcellus Inhibition 48.0 % 10.1016/s0960-894x(98)00524-1
Cavia porcellus Cavia porcellus Inhibition 58.0 % 10.1016/s0960-894x(00)00548-5
Cavia porcellus Cavia porcellus Inhibition 62.0 % 10.1016/s0960-894x(03)00405-0
Cavia porcellus Cavia porcellus Inhibition 95.4 % 10.1016/s0960-894x(03)00405-0
Cavia porcellus Cavia porcellus Reduction 15.0 % 10.1021/jm00037a021
Cavia porcellus Cavia porcellus Reduction 48.0 % 10.1021/jm00037a021
Cavia porcellus Cavia porcellus Reduction 58.0 % 10.1021/jm00037a021
Cavia porcellus Cavia porcellus Reduction 72.0 % 10.1021/jm9509096
Cavia porcellus Cavia porcellus Reduction 79.0 % 10.1021/jm9509096
Cavia porcellus Trachea EC50 26.3 nM 10.1016/j.ejmech.2020.112492
Cavia porcellus Trachea EC50 31.62 nM 10.1016/j.ejmech.2020.112492
Cavia porcellus Trachea EC50 64.57 nM 10.1016/j.ejmech.2020.112492
Cavia porcellus Trachea EC50 69.18 nM 10.1016/j.ejmech.2020.112492
Cercopithecidae Monkey Inhibition 33.4 % 10.1021/jm9800090
Cercopithecidae Monkey Inhibition 49.4 % 10.1021/jm9800090
Cercopithecidae Monkey Inhibition 84.0 % 10.1021/jm9800090
Cryptococcus neoformans Cryptococcus neoformans Inhibition -5.22 % 10.6019/CHEMBL4513141
Cryptococcus neoformans Cryptococcus neoformans MIC 20000.0 nM 10.6019/CHEMBL4513161
Danio rerio Danio rerio Activity nan None 10.1039/C2MD00273F
Escherichia coli Escherichia coli Inhibition 5.39 % 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC 20000.0 nM 10.6019/CHEMBL4513161
Homo sapiens A549 Activity 0.216 % 10.1016/j.ejmech.2021.113700
Homo sapiens A549 Activity 0.291 % 10.1016/j.ejmech.2021.113700
Homo sapiens A549 Activity 1.34 % 10.1016/j.ejmech.2021.113700
Homo sapiens A549 Activity 4.56 % 10.1016/j.ejmech.2021.113700
Homo sapiens A549 Activity 15.73 % 10.1016/j.ejmech.2021.113700
Homo sapiens A549 Activity 43.4 % 10.1016/j.bmcl.2017.12.019
Homo sapiens A549 Activity 79.7 % 10.1016/j.ejmech.2021.113700
Homo sapiens A549 Activity 98.2 % 10.1016/j.ejmech.2021.113700
Homo sapiens A549 Activity 101.2 % 10.1016/j.bmcl.2017.12.019
Homo sapiens A549 Activity 107.1 % 10.1016/j.bmcl.2017.12.019
Homo sapiens A549 Activity 113.7 % 10.1016/j.bmcl.2017.12.019
Homo sapiens A549 IC50 100000.0 nM 10.1016/j.ejmech.2021.113700
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1021/acs.jmedchem.5b01222
Homo sapiens Beta-2 adrenergic receptor Inhibition nan % 10.1016/j.bmcl.2009.01.057
Homo sapiens Blood IC50 1476.0 nM 10.1021/jm100524j
Homo sapiens Bloom syndrome protein Potency 1000.0 nM None
Homo sapiens Cannabinoid CB1 receptor Activity 83.0 % 10.1016/j.ejmech.2021.113189
Homo sapiens CEM-SS CC50 nan None 10.1016/j.bmcl.2007.12.015
Homo sapiens Cerebroside-sulfatase Potency 23.9 nM None
Homo sapiens Chromobox protein homolog 1 Potency 100000.0 nM None
Homo sapiens Cytochrome P450 3A4 Potency 19952.6 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 354.8 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 4466.8 nM None
Homo sapiens DNA polymerase iota Potency 11220.2 nM None
Homo sapiens Epoxide hydratase IC50 100000.0 nM 10.1021/acs.jmedchem.7b01804
Homo sapiens Flap endonuclease 1 Potency 8436.8 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 354.8 nM None
Homo sapiens HEK293 CC50 20000.0 nM 10.6019/CHEMBL4513161
Homo sapiens HEK293 Potency 65.1 nM None
Homo sapiens Histone deacetylase 6 Inhibition -9.14 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -6.89 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase MLL Potency 35481.3 nM None
Homo sapiens Homo sapiens IC50 37.9 nM 10.1021/jm970685m
Homo sapiens Homo sapiens IC50 225.0 nM 10.1016/s0960-894x(00)00449-2
Homo sapiens Homo sapiens IC50 225.0 nM 10.1016/s0960-894x(00)00587-4
Homo sapiens Homo sapiens IC50 320.0 nM 10.1021/jm00024a012
Homo sapiens Homo sapiens IC50 660.0 nM 10.1016/S0960-894X(97)00097-8
Homo sapiens Homo sapiens IC50 660.0 nM 10.1021/jm970685m
Homo sapiens Homo sapiens IC50 3100.0 nM 10.1021/jm991094u
Homo sapiens Homo sapiens Log IC50 6.1 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 29092.9 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 39810.7 nM None
Homo sapiens MAP kinase ERK2 Potency 3981.1 nM None
Homo sapiens MCF7 IC50 100000.0 nM 10.1016/j.ejmech.2021.113700
Homo sapiens MRC5 CC50 nan None 10.1021/jm301059b
Homo sapiens MT4 CC50 nan None 10.1016/j.bmcl.2007.12.015
Homo sapiens NCI-H460 IC50 100000.0 nM 10.1016/j.ejmech.2021.113700
Homo sapiens PBMC Activity 104.0 % 10.1016/j.ejmech.2018.01.049
Homo sapiens PBMC EC50 130.0 nM 10.1021/jm300514y
Homo sapiens PBMC IC50 60.0 nM 10.1021/jm701635j
Homo sapiens PBMC IC50 130.0 nM 10.1016/j.ejmech.2018.01.049
Homo sapiens PBMC IC50 150.0 nM 10.1016/s0960-894x(98)00475-2
Homo sapiens PBMC IC50 160.0 nM 10.1016/j.bmcl.2009.03.007
Homo sapiens PBMC IC50 230.0 nM 10.1016/j.bmcl.2009.03.007
Homo sapiens PBMC IC50 270.0 nM 10.1016/j.bmcl.2014.04.115
Homo sapiens PBMC IC50 500.0 nM 10.1016/j.bmcl.2009.03.007
Homo sapiens PBMC IC50 500.0 nM 10.1021/jm970575f
Homo sapiens PBMC IC50 880.0 nM 10.1016/j.bmcl.2009.03.007
Homo sapiens PBMC IC50 10850.0 nM 10.1016/j.bmc.2017.08.045
Homo sapiens PBMC IC50 12500.0 nM 10.1016/j.bmcl.2016.06.002
Homo sapiens PBMC IC50 18600.0 nM 10.1016/j.bmc.2017.01.047
Homo sapiens PBMC IC50 30000.0 nM 10.1016/j.bmcl.2017.11.026
Homo sapiens PBMC IC50 nan None 10.1016/j.ejmech.2018.01.049
Homo sapiens PBMC Inhibition 26.2 % 10.1016/j.bmcl.2015.11.035
Homo sapiens PBMC Inhibition 34.6 % 10.1016/j.bmcl.2015.11.035
Homo sapiens PBMC Inhibition 79.0 % 10.1016/j.ejmech.2018.01.049
Homo sapiens PBMC Inhibition nan % 10.1016/j.ejmech.2018.01.049
Homo sapiens PBMC Log IC50 5.6 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens PBMC Log IC50 5.7 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens PBMC Log IC50 6.3 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens PBMC Log IC50 7.1 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens PC-3 FC 1.065 None 10.1038/nchembio790
Homo sapiens Phosphodiesterase 1 IC25 1400.0 uM 10.1021/jm50001a001
Homo sapiens Phosphodiesterase 1 IC50 100000.0 nM 10.1021/jm9509096
Homo sapiens Phosphodiesterase 1 IC50 100000.0 nM 10.1021/jm980314l
Homo sapiens Phosphodiesterase 1 IC50 200000.0 nM 10.1016/s0960-894x(98)00491-0
Homo sapiens Phosphodiesterase 1 Inhibition 8.0 % 10.1021/jm00009a011
Homo sapiens Phosphodiesterase 1 Ki 200000.0 nM 10.1021/jm960827x
Homo sapiens Phosphodiesterase 10A Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 10A IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 10A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 10A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 11A Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 11A IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 11A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 11A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 11A IC50 nan None 10.1016/j.ejmech.2017.12.069
Homo sapiens Phosphodiesterase 1A IC50 50000.0 nM 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 1A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 1A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 1B Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 1B IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 1C IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 2A IC50 10000.0 nM 10.1016/j.bmcl.2005.02.025
Homo sapiens Phosphodiesterase 2A IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 2A IC50 100000.0 nM 10.1021/jm980314l
Homo sapiens Phosphodiesterase 2A IC50 100000.0 nM 10.1021/jm9905054
Homo sapiens Phosphodiesterase 2A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 2A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 2A Inhibition 5.0 % 10.1021/jm00009a011
Homo sapiens Phosphodiesterase 2A Inhibition 28.0 % 10.1016/s0960-894x(98)00491-0
Homo sapiens Phosphodiesterase 2A Ki 200000.0 nM 10.1021/jm960827x
Homo sapiens Phosphodiesterase 3 IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
Homo sapiens Phosphodiesterase 3 IC50 10000.0 nM 10.1016/j.bmcl.2005.02.025
Homo sapiens Phosphodiesterase 3 IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 3 IC50 100000.0 nM 10.1021/jm000315p
Homo sapiens Phosphodiesterase 3 IC50 100000.0 nM 10.1021/jm9509096
Homo sapiens Phosphodiesterase 3 IC50 100000.0 nM 10.1021/jm991094u
Homo sapiens Phosphodiesterase 3 IC50 242000.0 nM 10.1016/s0960-894x(00)00548-5
Homo sapiens Phosphodiesterase 3 IC50 242000.0 nM 10.1021/jm970105l
Homo sapiens Phosphodiesterase 3 IC50 242000.0 nM 10.1021/jm981012m
Homo sapiens Phosphodiesterase 3 IC50 300000.0 nM 10.1021/jm980314l
Homo sapiens Phosphodiesterase 3 Inhibition 14.0 % 10.1021/jm00009a011
Homo sapiens Phosphodiesterase 3 Inhibition 23.0 % 10.1016/0960-894X(95)00333-O
Homo sapiens Phosphodiesterase 3 Inhibition 27.0 % 10.1016/s0960-894x(00)00426-1
Homo sapiens Phosphodiesterase 3 Inhibition 27.0 % 10.1016/s0960-894x(01)00786-7
Homo sapiens Phosphodiesterase 3 Inhibition 27.0 % 10.1016/s0960-894x(02)00223-8
Homo sapiens Phosphodiesterase 3 Inhibition 27.0 % 10.1016/s0960-894x(98)00491-0
Homo sapiens Phosphodiesterase 3 Ki 200000.0 nM 10.1021/jm960827x
Homo sapiens Phosphodiesterase 3 Log IC50 4.0 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens Phosphodiesterase 3A Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 3A Activity nan None 10.1016/j.bmcl.2008.01.117
Homo sapiens Phosphodiesterase 3A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 3A Inhibition 9.42 % 10.1021/jm501090m
Homo sapiens Phosphodiesterase 3B IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 3B IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 3B IC50 nan None 10.1016/j.ejmech.2017.12.069
Homo sapiens Phosphodiesterase 4 Concentration 0.3 uM 10.1021/jm000065c
Homo sapiens Phosphodiesterase 4 Dose 0.1 None 10.1021/jm000065c
Homo sapiens Phosphodiesterase 4 IC50 20.0 nM 10.1016/s0960-894x(98)00491-0
Homo sapiens Phosphodiesterase 4 IC50 20.0 nM 10.1021/jm00037a021
Homo sapiens Phosphodiesterase 4 IC50 25.0 nM 10.1016/s0960-894x(98)00490-9
Homo sapiens Phosphodiesterase 4 IC50 50.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4 IC50 50.12 nM 10.1021/jm0110338
Homo sapiens Phosphodiesterase 4 IC50 60.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4 IC50 80.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4 IC50 150.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4 IC50 290.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4 IC50 320.0 nM 10.1016/s0960-894x(00)00548-5
Homo sapiens Phosphodiesterase 4 IC50 320.0 nM 10.1016/s0960-894x(97)10206-2
Homo sapiens Phosphodiesterase 4 IC50 320.0 nM 10.1016/s0960-894x(98)00324-2
Homo sapiens Phosphodiesterase 4 IC50 320.0 nM 10.1016/s0960-894x(98)00572-1
Homo sapiens Phosphodiesterase 4 IC50 320.0 nM 10.1021/jm970105l
Homo sapiens Phosphodiesterase 4 IC50 320.0 nM 10.1021/jm981012m
Homo sapiens Phosphodiesterase 4 IC50 400.0 nM 10.1016/j.bmcl.2012.04.094
Homo sapiens Phosphodiesterase 4 IC50 400.0 nM 10.1016/s0960-894x(98)00475-2
Homo sapiens Phosphodiesterase 4 IC50 410.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4 IC50 500.0 nM 10.1016/s0960-894x(03)00438-4
Homo sapiens Phosphodiesterase 4 IC50 500.0 nM 10.1021/jm980314l
Homo sapiens Phosphodiesterase 4 IC50 550.0 nM 10.1016/j.bmc.2015.10.033
Homo sapiens Phosphodiesterase 4 IC50 860.0 nM 10.1016/j.bmcl.2009.03.007
Homo sapiens Phosphodiesterase 4 IC50 880.0 nM 10.1039/C0MD00215A
Homo sapiens Phosphodiesterase 4 IC50 930.0 nM 10.1021/jm000315p
Homo sapiens Phosphodiesterase 4 IC50 1000.0 nM 10.1016/S0960-894X(00)80054-2
Homo sapiens Phosphodiesterase 4 IC50 1250.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4 IC50 1470.0 nM 10.1021/jm00037a021
Homo sapiens Phosphodiesterase 4 IC50 1600.0 nM 10.1021/jm00104a013
Homo sapiens Phosphodiesterase 4 IC50 1680.0 nM 10.1016/s0960-894x(00)00449-2
Homo sapiens Phosphodiesterase 4 IC50 1680.0 nM 10.1016/s0960-894x(00)00587-4
Homo sapiens Phosphodiesterase 4 IC50 1680.0 nM 10.1016/s0960-894x(01)00668-0
Homo sapiens Phosphodiesterase 4 IC50 2300.0 nM 10.1016/j.bmcl.2009.03.007
Homo sapiens Phosphodiesterase 4 IC50 3340.0 nM 10.1021/jm9800090
Homo sapiens Phosphodiesterase 4 IC50 3450.0 nM 10.1016/0960-894X(95)00334-P
Homo sapiens Phosphodiesterase 4 IC50 3450.0 nM 10.1021/jm9505066
Homo sapiens Phosphodiesterase 4 IC50 3500.0 nM 10.1016/0960-894X(95)00333-O
Homo sapiens Phosphodiesterase 4 IC50 3500.0 nM 10.1016/s0960-894x(00)00426-1
Homo sapiens Phosphodiesterase 4 IC50 3500.0 nM 10.1016/s0960-894x(01)00786-7
Homo sapiens Phosphodiesterase 4 IC50 3500.0 nM 10.1016/s0960-894x(02)00223-8
Homo sapiens Phosphodiesterase 4 IC50 3500.0 nM 10.1016/s0960-894x(98)00490-9
Homo sapiens Phosphodiesterase 4 IC50 3500.0 nM 10.1016/s0960-894x(98)00491-0
Homo sapiens Phosphodiesterase 4 IC50 3690.0 nM 10.1021/jm970685m
Homo sapiens Phosphodiesterase 4 IC50 4750.0 nM 10.1016/S0960-894X(97)00097-8
Homo sapiens Phosphodiesterase 4 IC50 5000.0 nM 10.1021/jm00127a009
Homo sapiens Phosphodiesterase 4 Inhibition 67.41 % 10.1016/j.ejmech.2007.06.013
Homo sapiens Phosphodiesterase 4 Inhibition 106.0 % 10.1039/C0MD00215A
Homo sapiens Phosphodiesterase 4 Kd 10.0 nM 10.1016/S0960-894X(01)80384-X
Homo sapiens Phosphodiesterase 4 Ki 1.6 nM 10.1016/s0960-894x(00)00449-2
Homo sapiens Phosphodiesterase 4 Ki 1.6 nM 10.1016/s0960-894x(00)00587-4
Homo sapiens Phosphodiesterase 4 Ki 1.6 nM 10.1016/s0960-894x(01)00668-0
Homo sapiens Phosphodiesterase 4 Ki 3.8 nM 10.1016/s0960-894x(03)00438-4
Homo sapiens Phosphodiesterase 4 Ki 3.8 nM 10.1021/jm980314l
Homo sapiens Phosphodiesterase 4 Ki 4.5 nM 10.1016/s0960-894x(97)10206-2
Homo sapiens Phosphodiesterase 4 Ki 4.5 nM 10.1016/s0960-894x(98)00324-2
Homo sapiens Phosphodiesterase 4 Ki 4.5 nM 10.1016/s0960-894x(98)00572-1
Homo sapiens Phosphodiesterase 4 Ki 190.0 nM 10.1016/S0960-894X(01)80384-X
Homo sapiens Phosphodiesterase 4 Ki 220.0 nM 10.1021/jm00026a003
Homo sapiens Phosphodiesterase 4 Ki 800.0 nM 10.1021/jm960827x
Homo sapiens Phosphodiesterase 4 Ki 1000.0 nM 10.1021/jm040217u
Homo sapiens Phosphodiesterase 4 Ratio 0.001 None 10.1016/s0960-894x(01)00668-0
Homo sapiens Phosphodiesterase 4 Ratio 53.0 None 10.1021/jm981012m
Homo sapiens Phosphodiesterase 4 Ratio 53.33 None 10.1021/jm970105l
Homo sapiens Phosphodiesterase 4 Ratio 130.0 None 10.1021/jm980314l
Homo sapiens Phosphodiesterase 4 Ratio 132.0 None 10.1016/s0960-894x(03)00438-4
Homo sapiens Phosphodiesterase 4 Ratio 175.0 None 10.1016/s0960-894x(01)00786-7
Homo sapiens Phosphodiesterase 4 Ratio 175.0 None 10.1016/s0960-894x(02)00223-8
Homo sapiens Phosphodiesterase 4 Ratio 175.0 None 10.1016/s0960-894x(98)00491-0
Homo sapiens Phosphodiesterase 4 R+V 36.5 90 min 10.1021/jm000315p
Homo sapiens Phosphodiesterase 4 Selectivity 600.0 None 10.1021/jm980314l
Homo sapiens Phosphodiesterase 4A EC50 500.0 nM 10.1021/jm200070e
Homo sapiens Phosphodiesterase 4A EC50 2620.0 nM 10.1039/C2MD00273F
Homo sapiens Phosphodiesterase 4A IC50 4.0 nM 10.1021/jm000065c
Homo sapiens Phosphodiesterase 4A IC50 10.7 nM 10.1021/jm970685m
Homo sapiens Phosphodiesterase 4A IC50 11.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4A IC50 67.0 nM 10.1016/j.ejmech.2020.112492
Homo sapiens Phosphodiesterase 4A IC50 84.0 nM 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 4A IC50 95.0 nM 10.1016/j.bmcl.2013.05.099
Homo sapiens Phosphodiesterase 4A IC50 162.0 nM 10.1021/jm300514y
Homo sapiens Phosphodiesterase 4A IC50 241.0 nM 10.1021/jm100524j
Homo sapiens Phosphodiesterase 4A IC50 386.0 nM 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 4A IC50 830.0 nM 10.1021/jm200070e
Homo sapiens Phosphodiesterase 4A IC50 1400.0 nM 10.1021/jm991094u
Homo sapiens Phosphodiesterase 4A IC50 1950.0 nM 10.1016/j.ejmech.2017.12.069
Homo sapiens Phosphodiesterase 4A IC50 nan None 10.1016/j.ejmech.2017.12.069
Homo sapiens Phosphodiesterase 4A Inhibition 79.0 % 10.1016/j.bmc.2015.04.027
Homo sapiens Phosphodiesterase 4A Inhibition 79.0 % 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4A Inhibition 79.0 % 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4A Ki 7940.0 nM 10.1021/jm030603w
Homo sapiens Phosphodiesterase 4A Log IC50 5.9 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens Phosphodiesterase 4B EC50 160.0 nM 10.1039/C2MD00273F
Homo sapiens Phosphodiesterase 4B EC50 220.0 nM 10.1016/j.bmc.2012.02.027
Homo sapiens Phosphodiesterase 4B FC 7.0 None 10.1016/j.bmcl.2013.12.117
Homo sapiens Phosphodiesterase 4B IC50 20.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4B IC50 34.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4B IC50 35.7 nM 10.1021/jm970685m
Homo sapiens Phosphodiesterase 4B IC50 50.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4B IC50 52.0 nM 10.1016/j.bmcl.2014.07.016
Homo sapiens Phosphodiesterase 4B IC50 80.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4B IC50 86.0 nM 10.1016/j.bmc.2015.10.033
Homo sapiens Phosphodiesterase 4B IC50 86.0 nM 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 4B IC50 97.9 nM 10.1021/jm501090m
Homo sapiens Phosphodiesterase 4B IC50 100.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4B IC50 105.0 nM 10.1016/j.bmcl.2007.12.015
Homo sapiens Phosphodiesterase 4B IC50 110.0 nM 10.1021/acsmedchemlett.9b00369
Homo sapiens Phosphodiesterase 4B IC50 150.0 nM 10.1016/j.ejmech.2019.02.026
Homo sapiens Phosphodiesterase 4B IC50 210.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4B IC50 220.0 nM 10.1016/j.ejmech.2020.112492
Homo sapiens Phosphodiesterase 4B IC50 231.0 nM 10.1021/jm300514y
Homo sapiens Phosphodiesterase 4B IC50 320.0 nM 10.1016/j.ejmech.2020.113125
Homo sapiens Phosphodiesterase 4B IC50 498.0 nM 10.1021/jm100524j
Homo sapiens Phosphodiesterase 4B IC50 534.0 nM 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 4B IC50 550.0 nM 10.1021/acs.jmedchem.5b01813
Homo sapiens Phosphodiesterase 4B IC50 625.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4B IC50 741.0 nM 10.1016/s0960-894x(01)00817-4
Homo sapiens Phosphodiesterase 4B IC50 901.0 nM 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 4B IC50 940.0 nM 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 4B IC50 940.0 nM 10.1016/j.ejmech.2021.113514
Homo sapiens Phosphodiesterase 4B IC50 940.0 nM 10.1039/C2MD00273F
Homo sapiens Phosphodiesterase 4B IC50 941.0 nM 10.1016/j.bmc.2013.01.023
Homo sapiens Phosphodiesterase 4B IC50 1000.0 nM 10.1016/j.ejmech.2012.12.052
Homo sapiens Phosphodiesterase 4B IC50 1030.0 nM 10.1016/j.bmcl.2020.127112
Homo sapiens Phosphodiesterase 4B IC50 1040.0 nM 10.1016/j.ejmech.2022.114497
Homo sapiens Phosphodiesterase 4B IC50 1100.0 nM 10.1016/j.ejmech.2018.01.068
Homo sapiens Phosphodiesterase 4B IC50 1100.0 nM 10.1016/j.ejmech.2018.09.021
Homo sapiens Phosphodiesterase 4B IC50 1120.0 nM 10.1016/j.ejmech.2020.112854
Homo sapiens Phosphodiesterase 4B IC50 1220.0 nM 10.1016/j.bmc.2017.08.045
Homo sapiens Phosphodiesterase 4B IC50 1220.0 nM 10.1016/j.bmcl.2018.02.056
Homo sapiens Phosphodiesterase 4B IC50 1270.0 nM 10.1016/j.ejmech.2017.12.069
Homo sapiens Phosphodiesterase 4B IC50 1300.0 nM 10.1016/j.bmcl.2015.08.043
Homo sapiens Phosphodiesterase 4B IC50 1500.0 nM 10.1016/j.bmcl.2016.06.002
Homo sapiens Phosphodiesterase 4B IC50 1800.0 nM 10.1016/j.bmc.2017.01.047
Homo sapiens Phosphodiesterase 4B IC50 1820.0 nM 10.1016/j.bmcl.2019.126720
Homo sapiens Phosphodiesterase 4B IC50 1900.0 nM 10.1016/j.bmcl.2018.03.031
Homo sapiens Phosphodiesterase 4B IC50 2000.0 nM 10.1016/j.bmcl.2008.01.117
Homo sapiens Phosphodiesterase 4B IC50 2000.0 nM 10.1016/j.bmcl.2018.04.068
Homo sapiens Phosphodiesterase 4B IC50 2000.0 nM 10.1016/j.ejmech.2020.112795
Homo sapiens Phosphodiesterase 4B IC50 4000.0 nM 10.1021/np300749w
Homo sapiens Phosphodiesterase 4B IC50 11370.0 nM 10.1016/j.bmcl.2019.126720
Homo sapiens Phosphodiesterase 4B IC50 16000.0 nM 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 4B IC50 18900.0 nM 10.1016/j.ejmech.2020.112795
Homo sapiens Phosphodiesterase 4B IC50 nan None 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4B Inhibition 65.0 % 10.1016/j.bmc.2015.04.027
Homo sapiens Phosphodiesterase 4B Inhibition 65.0 % 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4B Inhibition 65.0 % 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4B Inhibition 77.22 % 10.1016/j.ejmech.2021.113514
Homo sapiens Phosphodiesterase 4B Inhibition 84.0 % 10.1016/j.bmc.2019.07.046
Homo sapiens Phosphodiesterase 4B Inhibition 89.0 % 10.1016/j.ejmech.2014.08.057
Homo sapiens Phosphodiesterase 4B Inhibition 90.0 % 10.1007/s00044-011-9846-3
Homo sapiens Phosphodiesterase 4B Inhibition 90.0 % 10.1007/s00044-011-9892-x
Homo sapiens Phosphodiesterase 4B Inhibition 90.0 % 10.1016/j.bmc.2019.07.046
Homo sapiens Phosphodiesterase 4B Inhibition 90.0 % 10.1016/j.bmcl.2015.01.012
Homo sapiens Phosphodiesterase 4B Inhibition 90.0 % 10.1016/j.bmcl.2016.12.030
Homo sapiens Phosphodiesterase 4B Inhibition 90.12 % 10.1016/j.ejmech.2011.12.024
Homo sapiens Phosphodiesterase 4B Inhibition 94.12 % 10.1016/j.bmcl.2013.10.035
Homo sapiens Phosphodiesterase 4B Inhibition 100.0 % 10.1016/j.bmcl.2007.12.015
Homo sapiens Phosphodiesterase 4B Ki 5.0 nM 10.1016/j.ejmech.2020.113123
Homo sapiens Phosphodiesterase 4B Ki 220.0 nM 10.1016/0960-894X(95)00336-R
Homo sapiens Phosphodiesterase 4B Ki 221.0 nM 10.1021/jm00024a012
Homo sapiens Phosphodiesterase 4B Ki 223.87 nM 10.1021/jm00009a011
Homo sapiens Phosphodiesterase 4B Ki 1470.0 nM 10.1021/jm030603w
Homo sapiens Phosphodiesterase 4C IC50 118.0 nM 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 4C IC50 640.0 nM 10.1016/j.ejmech.2021.113700
Homo sapiens Phosphodiesterase 4C IC50 1258.0 nM 10.1016/j.ejmech.2020.112492
Homo sapiens Phosphodiesterase 4C IC50 1680.0 nM 10.1016/j.ejmech.2017.12.069
Homo sapiens Phosphodiesterase 4C IC50 2630.0 nM 10.1021/jm970685m
Homo sapiens Phosphodiesterase 4C IC50 3410.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4C IC50 3690.0 nM 10.1021/jm300514y
Homo sapiens Phosphodiesterase 4C IC50 7000.0 nM 10.1021/jm991094u
Homo sapiens Phosphodiesterase 4C IC50 59000.0 nM 10.1016/j.ejmech.2021.113700
Homo sapiens Phosphodiesterase 4C Inhibition 40.0 % 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 4C Inhibition 57.0 % 10.1016/j.bmc.2015.04.027
Homo sapiens Phosphodiesterase 4C Inhibition 57.0 % 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4C Inhibition 57.0 % 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4C Inhibition 70.0 % 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 4D EC50 670.0 nM 10.1039/C2MD00273F
Homo sapiens Phosphodiesterase 4D EC50 1100.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D IC30 283.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D IC50 31.6 nM 10.1021/jm970685m
Homo sapiens Phosphodiesterase 4D IC50 33.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D IC50 41.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D IC50 50.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4D IC50 60.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4D IC50 70.0 nM 10.1021/jm100524j
Homo sapiens Phosphodiesterase 4D IC50 79.0 nM 10.1016/j.ejmech.2020.112492
Homo sapiens Phosphodiesterase 4D IC50 80.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4D IC50 82.0 nM 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 4D IC50 82.5 nM 10.1021/jm501090m
Homo sapiens Phosphodiesterase 4D IC50 90.0 nM 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4D IC50 92.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D IC50 110.0 nM 10.1021/acsmedchemlett.9b00369
Homo sapiens Phosphodiesterase 4D IC50 130.0 nM 10.1016/j.bmcl.2014.07.016
Homo sapiens Phosphodiesterase 4D IC50 130.0 nM 10.1016/j.ejmech.2022.114503
Homo sapiens Phosphodiesterase 4D IC50 140.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4D IC50 160.0 nM 10.1016/j.bmc.2015.10.033
Homo sapiens Phosphodiesterase 4D IC50 160.0 nM 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 4D IC50 200.0 nM 10.1021/acs.jnatprod.9b00049
Homo sapiens Phosphodiesterase 4D IC50 240.0 nM 10.1021/acs.jmedchem.9b00518
Homo sapiens Phosphodiesterase 4D IC50 320.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4D IC50 390.0 nM 10.1021/jm991094u
Homo sapiens Phosphodiesterase 4D IC50 400.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D IC50 403.0 nM 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 4D IC50 500.0 nM 10.1021/acs.jnatprod.9b00049
Homo sapiens Phosphodiesterase 4D IC50 540.0 nM 10.1021/acs.jmedchem.0c00060
Homo sapiens Phosphodiesterase 4D IC50 549.54 nM 10.1021/jm701635j
Homo sapiens Phosphodiesterase 4D IC50 550.0 nM 10.1016/j.bmc.2010.01.070
Homo sapiens Phosphodiesterase 4D IC50 550.0 nM 10.1021/acs.jmedchem.5b01813
Homo sapiens Phosphodiesterase 4D IC50 550.0 nM 10.1021/jm701635j
Homo sapiens Phosphodiesterase 4D IC50 550.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D IC50 590.0 nM 10.1021/acs.jmedchem.1c01085
Homo sapiens Phosphodiesterase 4D IC50 590.0 nM 10.1021/jm800582j
Homo sapiens Phosphodiesterase 4D IC50 590.0 nM 10.1021/np401040d
Homo sapiens Phosphodiesterase 4D IC50 600.0 nM 10.1021/np500394d
Homo sapiens Phosphodiesterase 4D IC50 610.0 nM 10.1021/acs.jmedchem.5b01222
Homo sapiens Phosphodiesterase 4D IC50 620.0 nM 10.1016/j.ejmech.2017.12.057
Homo sapiens Phosphodiesterase 4D IC50 621.0 nM 10.1016/j.ejmech.2018.12.013
Homo sapiens Phosphodiesterase 4D IC50 622.0 nM 10.1021/jm300514y
Homo sapiens Phosphodiesterase 4D IC50 671.0 nM 10.1016/j.bmcl.2019.06.056
Homo sapiens Phosphodiesterase 4D IC50 880.0 nM 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 4D IC50 880.0 nM 10.1039/C2MD00273F
Homo sapiens Phosphodiesterase 4D IC50 910.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D IC50 1000.0 nM 10.1021/np500394d
Homo sapiens Phosphodiesterase 4D IC50 1050.0 nM 10.1016/j.ejmech.2017.12.069
Homo sapiens Phosphodiesterase 4D IC50 1170.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D IC50 1430.0 nM 10.1016/j.bmc.2017.08.045
Homo sapiens Phosphodiesterase 4D IC50 1430.0 nM 10.1016/j.bmcl.2018.02.056
Homo sapiens Phosphodiesterase 4D IC50 1690.0 nM 10.1016/j.bmcl.2019.126720
Homo sapiens Phosphodiesterase 4D IC50 2500.0 nM 10.1016/j.bmcl.2018.03.031
Homo sapiens Phosphodiesterase 4D IC50 2800.0 nM 10.1016/j.bmcl.2018.04.068
Homo sapiens Phosphodiesterase 4D IC50 2800.0 nM 10.1016/j.ejmech.2020.112795
Homo sapiens Phosphodiesterase 4D IC50 3000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D IC50 3500.0 nM 10.1016/j.bmc.2017.01.047
Homo sapiens Phosphodiesterase 4D IC50 4310.0 nM 10.1016/j.ejmech.2020.112854
Homo sapiens Phosphodiesterase 4D IC50 6500.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D IC50 13000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D IC50 17000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 4D Inhibition 78.0 % 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4D Inhibition 78.0 % 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D Inhibition 79.0 % 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4D Inhibition 79.0 % 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D Inhibition 80.0 % 10.1021/jm500855w
Homo sapiens Phosphodiesterase 4D Inhibition 80.0 % 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D Ki 58.9 nM 10.1021/jm8010993
Homo sapiens Phosphodiesterase 4D Ki 300.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D Ki 375.0 nM 10.1021/jm030603w
Homo sapiens Phosphodiesterase 4D Ki 382.0 nM 10.1021/jm030603w
Homo sapiens Phosphodiesterase 4D Ki 490.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D Ki 930.0 nM 10.1021/jm900977c
Homo sapiens Phosphodiesterase 4D Ki 8460.0 nM 10.1021/jm030603w
Homo sapiens Phosphodiesterase 4D Log IC50 6.4 nM 10.1016/s0960-894x(98)00583-6
Homo sapiens Phosphodiesterase 4D Selectivity index 1.0 None 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 5A Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 5A IC50 720.0 nM 10.1021/jm00039a024
Homo sapiens Phosphodiesterase 5A IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
Homo sapiens Phosphodiesterase 5A IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 5A IC50 100000.0 nM 10.1021/jm980314l
Homo sapiens Phosphodiesterase 5A IC50 100000.0 nM 10.1021/jm9905054
Homo sapiens Phosphodiesterase 5A IC50 200000.0 nM 10.1016/s0960-894x(98)00491-0
Homo sapiens Phosphodiesterase 5A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 5A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 5A Ki 200000.0 nM 10.1021/jm960827x
Homo sapiens Phosphodiesterase 6C IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 7A Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 7A IC50 200000.0 nM 10.1016/j.ejmech.2018.01.068
Homo sapiens Phosphodiesterase 7A IC50 200000.0 nM 10.1016/j.ejmech.2018.09.021
Homo sapiens Phosphodiesterase 7A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 7A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 7A Inhibition 3.1 % 10.1021/jm501090m
Homo sapiens Phosphodiesterase 7B Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 7B IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 8A IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 8A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 8A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase 8B IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 9A Activity nan None 10.1016/j.bmcl.2008.01.028
Homo sapiens Phosphodiesterase 9A IC50 16000.0 nM 10.1016/j.bmcl.2005.10.026
Homo sapiens Phosphodiesterase 9A IC50 nan None 10.1016/j.bmcl.2009.01.057
Homo sapiens Phosphodiesterase 9A IC50 nan None 10.1016/j.ejmech.2016.08.052
Homo sapiens Phosphodiesterase, PDE1/PDE5 IC50 94900.0 nM 10.1021/jm000315p
Homo sapiens Phosphodiesterase; PDE3 & PDE4 IC25 66.0 uM 10.1021/jm50001a001
Homo sapiens Phosphodiesterase; PDE3 & PDE4 Ratio 53.0 None 10.1021/jm9509096
Homo sapiens Protein cereblon IC50 202000.0 nM 10.1021/acsmedchemlett.0c00440
Homo sapiens Protein cereblon Ki 102000.0 nM 10.1021/acsmedchemlett.0c00440
Homo sapiens Serum albumin PPB 58.0 % 10.1016/j.bmcl.2013.05.099
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 3.1 % 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 8.5 % 10.1021/jm00381a019
Homo sapiens TNF-alpha IC50 200.0 nM 10.1016/j.bmcl.2017.11.026
Homo sapiens TNF-alpha IC50 500.0 nM 10.1016/j.bmcl.2017.11.026
Homo sapiens TNF-alpha IC50 500.0 nM 10.1016/j.ejmech.2021.113867
Homo sapiens TNF-alpha IC50 12000.0 nM 10.1021/jm940845j
Homo sapiens TNF-alpha Inhibition 50.3 % 10.1016/j.ejmech.2021.113514
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 16788.9 nM None
Homo sapiens U-251 Activity 0.745 % 10.1016/j.ejmech.2021.113700
Homo sapiens U-251 Activity 0.865 % 10.1016/j.ejmech.2021.113700
Homo sapiens U-251 Activity 1.96 % 10.1016/j.ejmech.2021.113700
Homo sapiens U-251 Activity 14.73 % 10.1016/j.ejmech.2021.113700
Homo sapiens U-251 Activity 16.85 % 10.1016/j.ejmech.2021.113700
Homo sapiens U-251 Activity 68.42 % 10.1016/j.ejmech.2021.113700
Homo sapiens U-251 Activity 96.4 % 10.1016/j.ejmech.2021.113700
Homo sapiens U-251 IC50 100000.0 nM 10.1016/j.ejmech.2021.113700
Homo sapiens U-937 EC50 1230.0 nM 10.1021/jm9800090
Homo sapiens U-937 IC50 1120.0 nM 10.1016/j.bmc.2017.08.042
Homo sapiens U-937 IC50 1170.0 nM 10.1016/j.bmc.2017.08.042
Homo sapiens U-937 IC50 1230.0 nM 10.1016/S0960-894X(97)00097-8
Homo sapiens U-937 Inhibition 53.53 % 10.1016/j.bmc.2017.08.042
Homo sapiens U-937 Inhibition 59.13 % 10.1016/j.bmc.2017.08.042
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 70794.6 nM None
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 nan None 10.1016/j.bmcl.2007.12.015
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan None 10.1016/j.bmcl.2007.12.015
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 nan None 10.1016/j.bmcl.2007.12.015
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 19.56 % 10.6019/CHEMBL4513141
Klebsiella pneumoniae Klebsiella pneumoniae MIC 20000.0 nM 10.6019/CHEMBL4513161
Mus musculus Mus musculus Activity 15.1 cm/s 10.1016/j.ejmech.2018.12.013
Mus musculus Mus musculus Activity 16.5 cm 10.1016/j.ejmech.2018.12.013
Mus musculus Mus musculus Activity 25.7 % 10.1016/j.ejmech.2018.12.013
Mus musculus Mus musculus Activity 33.5 % 10.1016/j.ejmech.2018.12.013
Mus musculus Mus musculus Activity 41.1 % 10.1016/j.ejmech.2018.12.013
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2015.04.027
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.12.013
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2020.112854
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.9b00193
Mus musculus Mus musculus Activity nan None 10.1021/jm300514y
Mus musculus Mus musculus Activity nan None 10.1021/jm501090m
Mus musculus Mus musculus Activity nan None 10.1021/jm8010993
Mus musculus Mus musculus ED50 2.6 mg.kg-1 10.1016/s0960-894x(03)00438-4
Mus musculus Mus musculus ED50 8.2 mg.kg-1 10.1016/s0960-894x(98)00572-1
Mus musculus Mus musculus Inhibition 6.0 % 10.1016/j.bmcl.2009.03.007
Mus musculus Mus musculus Inhibition 6.0 % 10.1016/j.bmcl.2010.02.010
Mus musculus Mus musculus Inhibition 6.0 % 10.1016/s0960-894x(01)00817-4
Mus musculus Mus musculus Inhibition 36.9 % 10.1016/j.bmcl.2015.11.035
Mus musculus Mus musculus Inhibition 39.0 % 10.1016/j.bmc.2013.07.007
Mus musculus Mus musculus Inhibition 40.8 % 10.1016/j.bmc.2017.01.047
Mus musculus Mus musculus Inhibition 41.0 % 10.1016/j.bmc.2017.08.045
Mus musculus Mus musculus Inhibition 41.2 % 10.1016/j.bmcl.2018.02.056
Mus musculus Mus musculus Inhibition 41.7 % 10.1016/j.bmcl.2018.03.031
Mus musculus Mus musculus Inhibition 42.9 % 10.1016/j.bmcl.2018.04.068
Mus musculus Mus musculus Inhibition 43.0 % 10.1016/s0960-894x(01)00817-4
Mus musculus Mus musculus Inhibition 45.3 % 10.1016/j.ejmech.2020.112795
Mus musculus Mus musculus Inhibition 48.1 % 10.1016/j.bmcl.2015.11.035
Mus musculus Mus musculus Inhibition 53.0 % 10.1016/j.bmcl.2009.03.007
Mus musculus Mus musculus Inhibition 53.0 % 10.1016/j.bmcl.2010.02.010
Mus musculus Mus musculus Inhibition 54.0 % 10.1021/jm300514y
Mus musculus Mus musculus Inhibition 55.0 % 10.1021/jm00009a011
Mus musculus Mus musculus Inhibition 55.0 % 10.1021/jm0110338
Mus musculus Mus musculus Inhibition 68.0 % 10.1016/S0960-894X(97)00097-8
Mus musculus Mus musculus Inhibition 68.0 % 10.1021/jm00009a011
Mus musculus Mus musculus Inhibition 69.0 % 10.1021/jm300514y
Mus musculus Mus musculus Inhibition 70.0 % 10.1021/jm300514y
Mus musculus Mus musculus Inhibition 95.0 % 10.1021/jm300514y
Mus musculus Mus musculus Inhibition 96.0 % 10.1021/jm300514y
Mus musculus Mus musculus Inhibition nan % 10.1016/j.bmcl.2019.126720
Mus musculus Mus musculus Inhibition nan % 10.1021/jm300514y
Mus musculus Mus musculus MED 3e-05 mg kg-1 10.1021/jm00106a024
Mus musculus Mus musculus MED 0.0001 mg kg-1 10.1021/jm00105a045
Mus musculus Mus musculus MED 1.78 mg kg-1 10.1021/jm00106a024
Mus musculus Mus musculus MED 1.8 mg kg-1 10.1021/jm00105a045
Mus musculus Mus musculus TIME 0.001583 hr 10.1016/j.ejmech.2018.12.013
Mus musculus Phosphodiesterase 4 IC50 4.0 nM 10.1016/0960-894X(95)00333-O
Mus musculus Phosphodiesterase 4 IC50 4.0 nM 10.1016/0960-894X(95)00334-P
Mus musculus Phosphodiesterase 4 IC50 4.0 nM 10.1021/jm9505066
Mus musculus RAW264.7 IC50 190.0 nM 10.1039/C2MD00273F
Mustela putorius furo Mustela putorius furo Activity 0.3 mg kg-1 10.1016/j.bmcl.2013.05.099
Mustela putorius furo Mustela putorius furo Activity nan None 10.1016/j.bmcl.2014.04.052
Mustela putorius furo Mustela putorius furo EC20 nan None 10.1021/jm00060a012
Mustela putorius furo Mustela putorius furo Emesis nan None 10.1016/s0960-894x(03)00405-0
Mustela putorius furo Mustela putorius furo Ferret emesis 2.0 None 10.1021/jm9505066
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 10.91 % 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20000.0 nM 10.6019/CHEMBL4513161
Rattus norvegicus Adenosine A1 receptor IC50 100000.0 nM 10.1021/jm00170a031
Rattus norvegicus Adenosine A2 receptor IC50 100000.0 nM 10.1021/jm00170a031
Rattus norvegicus PC-12 Activity nan None 10.1016/j.ejmech.2022.114503
Rattus norvegicus Phosphodiesterase 1 IC50 100000.0 nM 10.1021/jm00170a031
Rattus norvegicus Phosphodiesterase 2A IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
Rattus norvegicus Phosphodiesterase 4 IC50 0.31 nM 10.1016/s0960-894x(03)00405-0
Rattus norvegicus Phosphodiesterase 4 IC50 2.0 nM 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 IC50 2.6 nM 10.1021/jm00105a045
Rattus norvegicus Phosphodiesterase 4 IC50 2.6 nM 10.1021/jm00106a024
Rattus norvegicus Phosphodiesterase 4 IC50 5.0 nM 10.1016/s0960-894x(99)00573-9
Rattus norvegicus Phosphodiesterase 4 IC50 5.3 nM 10.1021/jm000315p
Rattus norvegicus Phosphodiesterase 4 IC50 6.0 nM 10.1016/s0960-894x(00)00548-5
Rattus norvegicus Phosphodiesterase 4 IC50 6.0 nM 10.1021/jm970105l
Rattus norvegicus Phosphodiesterase 4 IC50 6.0 nM 10.1021/jm981012m
Rattus norvegicus Phosphodiesterase 4 IC50 7.0 nM 10.1016/S0960-894X(00)80054-2
Rattus norvegicus Phosphodiesterase 4 IC50 20.0 nM 10.1016/s0960-894x(00)00426-1
Rattus norvegicus Phosphodiesterase 4 IC50 20.0 nM 10.1016/s0960-894x(01)00786-7
Rattus norvegicus Phosphodiesterase 4 IC50 20.0 nM 10.1016/s0960-894x(02)00223-8
Rattus norvegicus Phosphodiesterase 4 IC50 490.0 nM 10.1021/jm00105a045
Rattus norvegicus Phosphodiesterase 4 IC50 490.0 nM 10.1021/jm00106a024
Rattus norvegicus Phosphodiesterase 4 IC50 740.0 nM 10.1016/j.bmcl.2004.03.021
Rattus norvegicus Phosphodiesterase 4 IC50 1120.0 nM 10.1016/s0960-894x(02)00401-8
Rattus norvegicus Phosphodiesterase 4 IC50 1800.0 nM 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 Inhibition 29.7 uM 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 Inhibition 35.0 uM 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 Inhibition 43.8 uM 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 Inhibition 67.8 uM 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 Inhibition nan None 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 Ki 0.0023 nM 10.1016/s0960-894x(03)00405-0
Rattus norvegicus Phosphodiesterase 4 Ki 11.0 nM 10.1016/s0960-894x(01)00817-4
Rattus norvegicus Phosphodiesterase 4 Ratio 0.001 None 10.1016/s0960-894x(00)00681-8
Rattus norvegicus Phosphodiesterase 4 Selectivity 0.007 None 10.1016/s0960-894x(03)00405-0
Rattus norvegicus Phosphodiesterase 4B IC50 2700.0 nM 10.1021/jm991094u
Rattus norvegicus Phosphodiesterase 4B Log IC50 5.7 nM 10.1016/s0960-894x(98)00583-6
Rattus norvegicus Rattus norvegicus Activity 73.5 % 10.1016/j.ejmech.2020.112854
Rattus norvegicus Rattus norvegicus Activity 77.1 % 10.1016/j.ejmech.2020.112854
Rattus norvegicus Rattus norvegicus Activity 85.6 % 10.1016/j.ejmech.2020.112854
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.7b01804
Rattus norvegicus Rattus norvegicus ALB 38400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 44700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 45000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 284.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 286.6 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 331.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 403.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 29.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 60.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 69.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 73.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 74.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 76.6 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 99.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 133.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 146.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 153.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 154.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 558.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 633.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 696.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 826.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31800000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ED50 4.66 mg.kg-1 10.1021/jm000315p
Rattus norvegicus Rattus norvegicus EOS 109.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 142.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 174.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 252.2 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1270.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1318.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1443.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1706.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.84 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.7 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 40.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 132200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 139300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 143700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus IC50 40.0 nM 10.1016/s0960-894x(00)00449-2
Rattus norvegicus Rattus norvegicus IC50 250.0 nM 10.1021/jm00170a031
Rattus norvegicus Rattus norvegicus Inhibition 30.9 % 10.1016/j.bmc.2017.01.047
Rattus norvegicus Rattus norvegicus Inhibition 32.3 % 10.1016/j.bmc.2017.08.045
Rattus norvegicus Rattus norvegicus Inhibition 32.5 % 10.1016/j.bmcl.2018.02.056
Rattus norvegicus Rattus norvegicus Inhibition 32.8 % 10.1016/j.bmcl.2018.03.031
Rattus norvegicus Rattus norvegicus Inhibition 34.2 % 10.1016/j.bmcl.2018.04.068
Rattus norvegicus Rattus norvegicus Inhibition 36.8 % 10.1016/j.ejmech.2020.112795
Rattus norvegicus Rattus norvegicus Inhibition 41.0 % 10.1021/jm00106a024
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1016/j.bmcl.2019.126720
Rattus norvegicus Rattus norvegicus LAD 0.04 mg kg-1 10.1016/s0960-894x(01)00817-4
Rattus norvegicus Rattus norvegicus LDH 80.4 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 95.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 116.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 138.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7018.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8076.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9667.6 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 69.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 73.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 81.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 83.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.6 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.78 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 22.7 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.2 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 359300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 364700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 368800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 369700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.0 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.07 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.17 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.73 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MED 32.0 mg kg-1 10.1021/jm00170a031
Rattus norvegicus Rattus norvegicus MONO 257.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 387.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 432.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 605.6 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 12.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 23.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 25.2 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1082.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1493.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 3427.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 4994.6 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 90.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 99.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 110.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1039000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1088330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1123600.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1249330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.46 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.55 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.21 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 64000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 68000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5950000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6020000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6090000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6660000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 149.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 149.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 151.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 11.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8470.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10100.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14530.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15520.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 1000.0 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 7519.3 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 8.44 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.11 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.3072 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Inhibition 10.42 % 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 20000.0 nM 10.6019/CHEMBL4513161
Suncus murinus Suncus murinus Emesis 3.0 None 10.1021/jm970089s
Sus scrofa Phosphodiesterase 3A IC50 100000.0 nM 10.1021/jm9905054
Sus scrofa Phosphodiesterase 4A IC50 3630.0 nM 10.1021/jm9905054
Trypanosoma brucei Class 1 phosphodiesterase PDEB1 IC50 100000.0 nM 10.1021/jm301059b
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1021/jm301059b
Trypanosoma cruzi Cruzipain Potency 17782.8 nM None
Trypanosoma cruzi Cruzipain Potency 25118.9 nM None
Zika virus Zika virus Activity 7.0 log10PFU/ml 10.1016/j.bmcl.2017.12.019
Zika virus Zika virus IC50 44.6 nM 10.1016/j.bmcl.2017.12.019
None ADMET Activity 100.0 % 10.1021/acs.jmedchem.0c00060
None ADMET Activity nan None 10.1021/acs.jmedchem.1c01085
None ADMET EC50 320.0 nM 10.1021/jm00009a011
None ADMET IC50 310.0 nM 10.1016/S0960-894X(97)00097-8
None ADMET IC50 320.0 nM 10.1016/0960-894X(95)00336-R
None ADMET IC50 500.0 nM 10.1016/s0960-894x(00)00718-6
None ADMET IC50 30000.0 nM 10.1016/s0960-894x(00)00718-6
None ADMET permeability nan None 10.1021/acs.jmedchem.5b01222
None ADMET Plasma level 0.91 uM 10.1021/jm9800090
None ADMET PPB 67.12 % 10.6019/CHEMBL3301361
None ADMET PPB 82.72 % 10.6019/CHEMBL3301361
None Erythrocyte HC10 20.0 uM 10.6019/CHEMBL4513161
None NON-PROTEIN TARGET Activity 52.85 % 10.1016/j.bmcl.2009.02.050
None NON-PROTEIN TARGET Activity nan None 10.1021/jm201720d
None NON-PROTEIN TARGET Inhibition 36.1 % 10.1016/j.bmcl.2011.06.037
None NON-PROTEIN TARGET Inhibition 64.27 % 10.1016/j.bmcl.2011.06.037
None NON-PROTEIN TARGET Inhibition 71.48 % 10.1016/j.bmcl.2011.06.037
None NON-PROTEIN TARGET Inhibition nan % 10.1128/aac.00045-08
None NON-PROTEIN TARGET Potency 1.3 nM None
None NON-PROTEIN TARGET Potency 5.3 nM None
None NON-PROTEIN TARGET Potency 6.7 nM None
None NON-PROTEIN TARGET Potency 167.7 nM None
None NON-PROTEIN TARGET Potency 5623.4 nM None
None NON-PROTEIN TARGET Potency 8912.5 nM None
None No relevant target Activity 0.07 equiv 10.1016/j.ejmech.2018.12.013
None No relevant target Activity nan None 10.1021/acs.jmedchem.5b01222
None No relevant target Peff 18.87 10'-6 cm/s 10.1016/j.ejmech.2018.12.013
None No relevant target Solubility 171.0 ug.mL-1 10.1016/j.bmcl.2013.05.099
None No relevant target Solubility 750000.0 nM 10.1021/acs.jmedchem.7b01804
None T-cell IC50 10000.0 nM 10.1016/s0960-894x(00)00718-6
None Unchecked AbsAC40_uM 1.98 uM None
None Unchecked Ac50 7.943 uM None
None Unchecked AC50 7943.3 nM None
None Unchecked Activity nan None 10.1021/acsmedchemlett.9b00369
None Unchecked EC50 131.5 nM 10.1016/j.bmcl.2009.01.057
None Unchecked EC50 340.0 nM 10.1021/acs.jmedchem.7b01804
None Unchecked ED50 8.0 mg.kg-1 10.1021/jm970575f
None Unchecked IC50 2.512 nM 10.1016/j.ejmech.2022.114170
None Unchecked IC50 5.7 nM 10.1016/j.bmcl.2013.01.025
None Unchecked IC50 54.0 nM 10.1016/j.bmc.2013.07.007
None Unchecked IC50 83.0 nM 10.1021/jm000315p
None Unchecked IC50 100.0 nM 10.1021/jm950197j
None Unchecked IC50 102.0 nM 10.1016/j.bmcl.2009.01.057
None Unchecked IC50 200.0 nM 10.1021/jm701575k
None Unchecked IC50 231.0 nM 10.1021/acs.jmedchem.7b01370
None Unchecked IC50 288.0 nM 10.1021/acs.jmedchem.5b01813
None Unchecked IC50 300.0 nM 10.1016/j.ejmech.2019.02.026
None Unchecked IC50 500.0 nM 10.1016/j.ejmech.2017.09.077
None Unchecked IC50 550.0 nM 10.1016/j.ejmech.2016.08.052
None Unchecked IC50 590.0 nM 10.1021/jm00106a024
None Unchecked IC50 600.0 nM 10.1016/j.bmcl.2011.09.109
None Unchecked IC50 740.0 nM 10.1016/j.bmcl.2005.02.025
None Unchecked IC50 800.0 nM 10.1021/jm00060a012
None Unchecked IC50 800.0 nM 10.1021/jm300514y
None Unchecked IC50 940.0 nM 10.1021/jm000315p
None Unchecked IC50 1000.0 nM 10.1016/j.bmcl.2016.11.040
None Unchecked IC50 1000.0 nM 10.1016/j.ejmech.2018.03.046
None Unchecked IC50 1000.0 nM 10.1016/j.ejmech.2022.114170
None Unchecked IC50 1900.0 nM 10.1021/jm9509096
None Unchecked IC50 3340.0 nM 10.1021/jm060904g
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2005.02.025
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2012.04.094
None Unchecked IC50 10850.0 nM 10.1016/j.bmcl.2018.02.056
None Unchecked IC50 16500.0 nM 10.1016/j.bmcl.2018.03.031
None Unchecked IC50 18900.0 nM 10.1016/j.bmcl.2018.04.068
None Unchecked IC50 100000.0 nM 10.1021/jm201148s
None Unchecked IC50 100000.0 nM 10.1021/jm9509096
None Unchecked IC50 100000.0 nM 10.1021/jm9905054
None Unchecked Inhibition -94.0 % 10.1021/jm000315p
None Unchecked Inhibition 16.0 % 10.1016/j.bmcl.2013.01.025
None Unchecked Inhibition 28.0 % 10.1021/jm00060a012
None Unchecked Inhibition 54.0 % 10.1016/j.bmcl.2014.04.052
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.9b00369
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ki 2.1 nM 10.1016/j.bmcl.2013.01.025
None Unchecked Ki 60.0 nM 10.1021/jm800582j
None Unchecked Log IC50 8.4 nM 10.1016/s0960-894x(98)00583-6
None Unchecked Potency 4466.8 nM None
None Unchecked Potency 5011.9 nM None
None Unchecked Potency 39810.7 nM None
None Unchecked Ratio 3.6 None 10.1021/jm991094u
None Unchecked Ratio 175.0 None 10.1016/s0960-894x(00)00426-1
None Unchecked Ratio IC50 0.5 None 10.1016/j.bmc.2015.10.033
None Unchecked Ratio IC50 0.54 None 10.1016/j.bmc.2015.10.033
None Unchecked Ratio IC50 1.4 None 10.1016/j.bmcl.2018.04.068
None Unchecked Ratio IC50 1.4 None 10.1016/j.ejmech.2020.112795
None Unchecked Ratio Ki 1.6 None 10.1021/jm900977c
None Unchecked Ratio Ki 3.1 None 10.1021/jm900977c
None Unchecked RBA 27.0 % 10.1021/jm800582j

Metabolism Information